SAKL0A00132g 0 9038 9973 ON 1 A00132 complement(9038..9973) highly similar to gnl|GLV|KLLA0F17864g Kluyveromyces lactis KLLA0F17864g and similar to YPR058W uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family SAKL0A00154g 0 13363 15120 ON 1 A00154 complement(13363..15120) highly similar to uniprot|P40884 Saccharomyces cerevisiae YJL216C Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance SAKL0A00176g 0 17318 18049 ON 1 A00176 complement(17318..18049) similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W Hypothetical ORF SAKL0A00198g 1 19808 20776 ON 1 A00198 (19808..20776) weakly similar to uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing SAKL0A00220g 1 20959 22908 ON 1 A00220 (20959..21768,22183..22908) similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation SAKL0A00242g 1 23416 24711 ON 1 A00242 (23416..24711) similar to uniprot|P39008 YNR052C Saccharomyces cerevisiae POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation SAKL0A00264g 0 25193 29035 ON 1 A00264 complement(25193..29035) highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF SAKL0A00286g 0 30201 30755 ON 1 A00286 complement(30201..30755) uniprot|Q9UVP9 Saccharomyces kluyveri weakly similar to YNR049C uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 SAKL0A00308g 0 32763 34103 ON 1 A00308 complement(32763..34103) highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming) SAKL0A00330g 0 34777 35839 ON 1 A00330 complement(34777..35732,35794..35839) similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0A00352g 0 38015 39487 ON 1 A00352 complement(38015..39487) some similarities with uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor SAKL0A00374g 1 41784 43442 ON 1 A00374 (41784..43442) similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF SAKL0A00396g 0 43630 44277 ON 1 A00396 complement(43630..44277) highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER- associated protein degradation (ERAD) component of the cellular stress response SAKL0A00418g 0 45284 46480 ON 1 A00418 complement(45284..46480) similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity SAKL0A00440g 0 46692 53111 ON 1 A00440 complement(46692..53111) some similarities with uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels SAKL0A00462g 1 54642 57824 ON 1 A00462 (54642..57824) similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability SAKL0A00484g 0 57938 60544 ON 1 A00484 complement(57938..60544) similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate SAKL0A00506g 0 61447 61848 ON 1 A00506 complement(61447..61848) highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability SAKL0A00528g 0 62392 63687 ON 1 A00528 complement(62392..63687) similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane SAKL0A00550g 1 63896 64456 ON 1 A00550 (63896..64456) similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF SAKL0A00572g 0 64588 67938 ON 1 A00572 complement(64588..67938) some similarities with uniprot|P25653 Saccharomyces cerevisiae YCR089W FIG2 Cell wall adhesin expressed specifically during mating may be involved in maintenance of cell wall integrity during mating SAKL0A00594g 0 68426 70336 ON 1 A00594 complement(68426..70336) some similarities with uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization SAKL0A00616g 1 70602 71069 ON 1 A00616 (70602..71069) similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF SAKL0A00638g 0 71092 71628 ON 1 A00638 complement(71092..71628) similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication SAKL0A00660g 1 71855 73837 ON 1 A00660 (71855..73837) some similarities with uniprot|P18323 Saccharomyces cerevisiae YCR084C SAKL0A00704g 0 78811 80967 ON 1 A00704 complement(78811..80967) similar to uniprot|P35995 Saccharomyces cerevisiae YKL222C Hypothetical ORF and similar to uniprot|Q12340 Saccharomyces cerevisiae YOR172W SAKL0A00726g 1 82164 83960 ON 1 A00726 (82164..83960) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF SAKL0A00748g 0 84444 85774 ON 1 A00748 complement(84444..85592,85730..85774) similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer SAKL0A00770g 1 86003 87106 ON 1 A00770 (86003..87106) similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis SAKL0A00792g 0 87181 88008 ON 1 A00792 complement(87181..88008) similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF SAKL0A00814g 0 88183 88566 ON 1 A00814 complement(88183..88566) similar to uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin SAKL0A00836g 0 89267 89650 ON 1 A00836 complement(89267..89650) similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 component of the yeast ADA acetyltransferase complex SAKL0A00858g 1 90495 92225 ON 1 A00858 (90495..92225) similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc SAKL0A00880g 0 92246 93412 ON 1 A00880 complement(92246..93412) similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione- dependent formaldehyde dehydrogenase) SAKL0A00902g 0 93631 97722 ON 1 A00902 complement(93631..97722) similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit SAKL0A00924g 0 98231 100150 ON 1 A00924 complement(98231..100150) similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD- box protein family SAKL0A00946g 1 100349 100624 ON 1 A00946 (100349..100624) highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C SAKL0A00968g 0 100755 102236 ON 1 A00968 complement(100755..102236) similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF SAKL0A00990g 1 103185 103676 ON 1 A00990 (103185..103676) highly similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C SAKL0A01012g 1 103936 104895 ON 1 A01012 (103936..104895) highly similar to gnl|GLV|CAGL0G07909g Candida glabrata CAGL0G07909g and similar to YNR035C uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin SAKL0A01034g 1 105182 107737 ON 1 A01034 (105182..107737) similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation- dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p SAKL0A01056g 1 108508 109431 ON 1 A01056 (108508..109431) similar to gnl|GLV|KLLA0F27379g Kluyveromyces lactis KLLA0F27379g and some similarites with YCR076C uniprot|P25659 Saccharomyces cerevisiae YCR076C Hypothetical ORF SAKL0A01078g 0 109500 109754 ON 1 A01078 complement(109500..109754) similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii SAKL0A01100g 1 109909 111642 ON 1 A01100 (109909..111642) conserved hypothetical protein SAKL0A01122g 0 111768 113342 ON 1 A01122 complement(111768..113342) some similarities with uniprot|P40530 Saccharomyces cerevisiae YIL042C SAKL0A01144g 1 113572 114327 ON 1 A01144 (113572..114327) similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C SAKL0A01166g 0 114476 115423 ON 1 A01166 complement(114476..115423) similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W SAKL0A01188g 0 115841 118105 ON 1 A01188 complement(115841..118105) similar to uniprot|Q6B1Q1 Saccharomyces cerevisiae YNR033W SAKL0A01210g 1 118298 118519 ON 1 A01210 (118298..118519) similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 SAKL0A01232g 0 118646 119767 ON 1 A01232 complement(118646..119767) highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases SAKL0A01254g 1 119884 124560 ON 1 A01254 (119884..124560) similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p SAKL0A01276g 1 124778 126325 ON 1 A01276 (124778..126325) highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability SAKL0A01298g 1 126552 127061 ON 1 A01298 (126552..127061) similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit SAKL0A01320g 0 127228 128859 ON 1 A01320 complement(127228..128859) similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation SAKL0A01342g 1 129065 130291 ON 1 A01342 (129065..130291) similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF SAKL0A01364g 0 130532 131464 ON 1 A01364 complement(130532..131464) similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues has a potential role in the secretory pathway SAKL0A01386g 1 132287 134599 ON 1 A01386 (132287..134599) conserved hypothetical protein SAKL0A01408g 0 134761 136377 ON 1 A01408 complement(134761..136377) similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway SAKL0A01430g 0 136728 137636 ON 1 A01430 complement(136728..137636) similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0A01452g 1 137799 140771 ON 1 A01452 (137799..140771) similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p SAKL0A01474g 0 140890 142296 ON 1 A01474 complement(140890..142296) similar to gnl|GLV|CAGL0J03586g Candida glabrata CAGL0J03586g and weakly similar to YCR066W uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif SAKL0A01496g 0 142658 144517 ON 1 A01496 complement(142658..144517) some similarities with uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly SAKL0A01518g 0 144844 145317 ON 1 A01518 complement(144844..145317) highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Sklu_1.trna1S 0 145549 145643 ON 1 tS-CGA complement(145549..145593,145607..145643) tRNA Type: Ser (S) | Anti-Codon: CGA | Cove Score: 75.05 SAKL0A01628g 0 146660 148537 ON 1 A01628 complement(146660..148537) similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0A01650g 1 149814 154898 ON 1 A01650 (149814..154898) similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 SAKL0A01672g 0 154932 155318 ON 1 A01672 complement(154932..155318) similar to uniprot|P25638 Saccharomyces cerevisiae YCR060W TAH1 HSP90 SAKL0A01694g 1 155740 156558 ON 1 A01694 (155740..156558) similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN) SAKL0A01716g 0 156620 157123 ON 1 A01716 complement(156620..157123) similar to gnl|GLV|KLLA0C08954g Kluyveromyces lactis KLLA0C08954g and weakly similar to YNR024W uniprot|P53725 Saccharomyces cerevisiae YNR024W Hypothetical ORF SAKL0A01738g 1 157360 160089 ON 1 A01738 (157360..160089) highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein SAKL0A01760g 1 160282 161919 ON 1 A01760 (160282..161919) similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function SAKL0A01782g 0 162048 163580 ON 1 A01782 complement(162048..163580) highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase SAKL0A01804g 0 163950 165383 ON 1 A01804 complement(163950..165383) similar to uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex SAKL0A01826g 1 165630 166034 ON 1 A01826 (165630..166034) similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation SAKL0A01848g 0 166123 167349 ON 1 A01848 complement(166123..167349) similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF SAKL0A01870g 0 167727 168347 ON 1 A01870 complement(167727..168347) highly similar to gnl|GLV|CAGL0C03003g Candida glabrata CAGL0C03003g and similar to YCR051W uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF SAKL0A01892g 1 168559 169299 ON 1 A01892 (168559..169299) highly similar to gnl|GLV|KLLA0C09130g Kluyveromyces lactis KLLA0C09130g and similar to YNR020C uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF SAKL0A01914g 0 169392 171146 ON 1 A01914 complement(169392..171146) uniprot|Q875S8 Saccharomyces kluyveri ARE2 Acyl- CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen SAKL0A01936g 1 171486 172292 ON 1 A01936 (171486..172292) highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0A01958g 1 172884 173402 ON 1 A01958 (172884..173402) similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome SAKL0A01980g 0 173811 174479 ON 1 A01980 complement(173811..174479) similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF SAKL0A02002g 1 176105 177544 ON 1 A02002 (176105..177544) similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C Hypothetical ORF SAKL0A02024g 0 177869 178534 ON 1 A02024 complement(177869..178534) similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system SAKL0A02046g 1 180654 187349 ON 1 A02046 (180654..187349) highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids or YMR207C uniprot|P32874 Saccharomyces cerevisiae YMR207C HFA1 Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis SAKL0A02068g 0 187734 188927 ON 1 A02068 complement(187734..188927) similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase SAKL0A02090g 1 189462 193433 ON 1 A02090 (189462..193433) conserved hypothetical protein SAKL0A02112g 0 193591 194448 ON 1 A02112 complement(193591..194448) some similarities with uniprot|Q03695 Saccharomyces cerevisiae YMR206W SAKL0A02134g 1 195606 198287 ON 1 A02134 (195606..198287) similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth SAKL0A02156g 0 198529 200055 ON 1 A02156 complement(198529..200055) highly similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase SAKL0A02178g 1 200332 203007 ON 1 A02178 (200332..203007) similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing SAKL0A02200g 0 203497 206955 ON 1 A02200 complement(203497..206955) some similarities with uniprot|P38894 Saccharomyces YHR211W cerevisiae FLO5 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p and some similarites with YAR050W uniprot|P32768 Saccharomyces cerevisiae FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p SAKL0A02222g 0 207796 208363 ON 1 A02222 complement(207796..208129,208350..208363) no similarity SAKL0A02244g 1 208778 209803 ON 1 A02244 (208778..209803) highly similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S- D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress SAKL0A02266g 1 210571 213462 ON 1 A02266 (210571..213462) highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6- bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes SAKL0A02288g 1 214493 215782 ON 1 A02288 (214493..215782) similar to uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF SAKL0A02310g 0 215994 217163 ON 1 A02310 complement(215994..217163) highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore SAKL0A02332g 0 217375 217737 ON 1 A02332 complement(217375..217737) some similarities with uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity SAKL0A02354g 0 218080 218748 ON 1 A02354 complement(218080..218748) highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis SAKL0A02376g 0 219750 220367 ON 1 A02376 complement(219750..220367) weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W Hypothetical ORF SAKL0A02398g 0 220643 222538 ON 1 A02398 complement(220643..222538) similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase SAKL0A02420g 1 222751 223635 ON 1 A02420 (222751..223635) similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p- phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy SAKL0A02442g 1 223806 224987 ON 1 A02442 (223806..223835,223920..224987) similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein SAKL0A02464g 0 225189 227039 ON 1 A02464 complement(225189..227039) similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function SAKL0A02486g 0 227683 228441 ON 1 A02486 complement(227683..228441) similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations SAKL0A02508g 0 228855 230399 ON 1 A02508 complement(228855..230399) similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START G(sub)1 cyclin SAKL0A02530g 0 230990 232069 ON 1 A02530 complement(230990..232069) conserved hypothetical protein SAKL0A02552g 1 232406 233581 ON 1 A02552 (232406..233581) weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p SAKL0A02574g 1 233948 235282 ON 1 A02574 (233948..235282) similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase- coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions SAKL0A02596g 0 235391 237295 ON 1 A02596 complement(235391..237295) weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule- mediated processes; required for sister chromatid cohesion SAKL0A02618g 0 238247 238735 ON 1 A02618 complement(238247..238735) similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis SAKL0A02640g 1 239111 239767 ON 1 A02640 (239111..239767) highly similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t- SNARES Sed5p and Pep12p SAKL0A02662g 0 239864 243130 ON 1 A02662 complement(239864..243130) highly similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Hypothetical ORF SAKL0A02684g 0 244463 244831 ON 1 A02684 complement(244463..244831) similar to uniprot|Q12048 Saccharomyces cerevisiae YPL250C Protein of unknown function SAKL0A02706g 1 245778 246488 ON 1 A02706 (245778..246488) no similarity Sklu_YGOB_Anc_6.284 1 246723 247052 ON 1 Anc_6.284 (246723..246759,246859..247052) ANNOTATED BY YGOB - SAKL0A02728g 0 247966 248613 ON 1 A02728 complement(247966..248613) conserved hypothetical protein SAKL0A02750g 1 250260 251096 ON 1 A02750 (250260..251096) conserved hypothetical protein SAKL0A02772g 0 251715 252524 ON 1 A02772 complement(251715..252001,252509..252524) highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit SAKL0A02794g 0 253809 254579 ON 1 A02794 complement(253809..254579) highly similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit SAKL0A02816g 0 254792 257407 ON 1 A02816 complement(254792..257407) similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p involved in ER to Golgi trafficking interacts with the yeast amphiphysins Rvs161p and Rvs167p SAKL0A02838g 0 257960 259057 ON 1 A02838 complement(257960..259057) some similarities with uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources SAKL0A02860g 0 259388 261625 ON 1 A02860 complement(259388..261625) similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose repressed by Gal80p and activated by Gal3p SAKL0A02882g 0 262348 262701 ON 1 A02882 complement(262348..262701) some similarities with uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability SAKL0A02904g 1 263239 267465 ON 1 A02904 (263239..267465) similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity SAKL0A02926g 0 267564 269282 ON 1 A02926 complement(267564..269282) similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide SAKL0A02948g 0 270179 273211 ON 1 A02948 complement(270179..273211) highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm SAKL0A02970g 0 275095 276342 ON 1 A02970 complement(275095..276342) similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF SAKL0A02992g 1 276753 277448 ON 1 A02992 (276753..277448) similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit SAKL0A03014g 0 277610 278484 ON 1 A03014 complement(277610..278253,278328..278484) similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p SAKL0A03036g 1 278871 280214 ON 1 A03036 (278871..280214) similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF SAKL0A03058g 0 280249 281217 ON 1 A03058 complement(280249..281217) highly similar to uniprot|P40447 Saccharomyces cerevisiae YIL164C NIT1 Nitrilase member of the widely found nitrilase branch (EC:3.5.5.1) of the nitrilase superfamily SAKL0A03080g 0 282143 283156 ON 1 A03080 complement(282143..283156) similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen SAKL0A03102g 1 283324 285078 ON 1 A03102 (283324..285078) similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane SAKL0A03124g 1 285286 286587 ON 1 A03124 (285286..286587) similar to uniprot|Q03236 Saccharomyces cerevisiae YMR187C Hypothetical ORF SAKL0A03146g 1 286624 288390 ON 1 A03146 (286624..288390) conserved hypothetical protein SAKL0A03168g 1 289005 289952 ON 1 A03168 (289005..289952) conserved hypothetical protein SAKL0A03190g 0 290009 294670 ON 1 A03190 complement(290009..294670) similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p SAKL0A03212g 0 294871 295602 ON 1 A03212 complement(294871..295602) weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl SAKL0A03234g 0 296215 298335 ON 1 A03234 complement(296215..298335) highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family SAKL0A03256g 0 299306 302251 ON 1 A03256 complement(299306..302251) similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability SAKL0A03278g 1 302501 303097 ON 1 A03278 (302501..303097) similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1 SAKL0A03300g 1 303394 304248 ON 1 A03300 (303394..304248) similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon SAKL0A03322g 0 304459 305004 ON 1 A03322 complement(304459..305004) similar to uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF SAKL0A03344g 0 305149 306243 ON 1 A03344 complement(305149..306243) similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Hypothetical ORF SAKL0A03366g 1 306422 307840 ON 1 A03366 (306422..307840) highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue SAKL0A03388g 0 307969 308463 ON 1 A03388 complement(307969..308463) highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c' SAKL0A03410g 1 308699 309352 ON 1 A03410 (308699..309352) similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation SAKL0A03432g 1 309774 310652 ON 1 A03432 (309774..310652) similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W SSO1 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE SAKL0A03454g 1 312031 317703 ON 1 A03454 (312031..317703) uniprot|Q765N2 Saccharomyces kluyveri Sk Fatty acid synthase alpha-subunit SAKL0A03476g 1 319246 320214 ON 1 A03476 (319246..320214) some similarities with uniprot|Q12132 Saccharomyces cerevisiae YPL230W USV1 Up in StarVation SAKL0A03498g 1 320680 321087 ON 1 A03498 (320680..321087) some similarities with uniprot|Q03231 Saccharomyces cerevisiae YMR181C and to uniprot|Q99395 Saccharomyces cerevisiae YPL229W SAKL0A03520g 1 321709 323232 ON 1 A03520 (321709..323232) similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate- terminated RNA mRNA capping enzyme beta subunit RNA 5'- triphosphatase SAKL0A03542g 0 323420 324424 ON 1 A03542 complement(323420..324424) similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum SAKL0A03564g 0 325078 327216 ON 1 A03564 complement(325078..327216) weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2- HHT2 but not required at the other histone loci functionally related to Spt10p SAKL0A03586g 1 328346 331885 ON 1 A03586 (328346..331885) similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU] SAKL0A03608g 0 332009 332899 ON 1 A03608 complement(332009..332899) similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF SAKL0A03630g 1 333187 333627 ON 1 A03630 (333187..333627) highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF SAKL0A03652g 0 333762 335297 ON 1 A03652 complement(333762..335297) similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p SAKL0A03674g 0 335510 340402 ON 1 A03674 complement(335510..340402) similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks SAKL0A03696g 0 341196 341714 ON 1 A03696 complement(341196..341714) conserved hypothetical protein Sklu_YGOB_PAI3 1 342789 342962 ON 1 PAI3 (342789..342962) ANNOTATED BY YGOB - SAKL0A03718g 0 343874 345295 ON 1 A03718 complement(343874..345295) similar to uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein expression is increased in response to heat-shock stress or treatments that produce DNA lesions SAKL0A03740g 0 345988 347982 ON 1 A03740 complement(345988..347982) some similarities with uniprot|Q03213 Saccharomyces cerevisiae YMR172W HOT1 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity SAKL0A03762g 1 348183 350264 ON 1 A03762 (348183..350264) similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria SAKL0A03784g 1 351026 352282 ON 1 A03784 (351026..352282) no similarity SAKL0A03806g 1 353414 356539 ON 1 A03806 (353414..356539) weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria SAKL0A03828g 1 356955 359354 ON 1 A03828 (356955..359354) similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation SAKL0A03850g 0 359511 361142 ON 1 A03850 complement(359511..361142) similar to gnl|GLV|KLLA0B01936g Kluyveromyces lactis KLLA0B01936g and weakly similar to YGL138C uniprot|P53122 Saccharomyces cerevisiae YGL138C Hypothetical ORF SAKL0A03872g 1 361507 364338 ON 1 A03872 (361507..361524,361720..364338) similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer SAKL0A03894g 0 364523 365470 ON 1 A03894 complement(364523..365470) highly similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ SAKL0A03916g 1 365969 366622 ON 1 A03916 (365969..366622) highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N- terminally acetylated protein component of the large (60S) ribosomal subunit SAKL0A03938g 1 367076 368581 ON 1 A03938 (367076..368581) weakly similar to uniprot|Q6B153 Saccharomyces cerevisiae YPL219W PCL8 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase also activates Pho85p for Glc8p phosphorylation SAKL0A03960g 1 368829 369467 ON 1 A03960 (368829..368850,368923..369467) highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport SAKL0A03982g 0 369575 373072 ON 1 A03982 complement(369575..373072) highly similar to gnl|GLV|KLLA0B02068g Kluyveromyces lactis KLLA0B02068g and similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre- rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p SAKL0A04004g 1 373666 377208 ON 1 A04004 (373666..377208) similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a- specific genes repression of early meiotic genes during mitotic growth and repression of INO1 SAKL0A04026g 1 377302 378408 ON 1 A04026 (377302..378408) similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex SAKL0A04048g 0 378483 380099 ON 1 A04048 complement(378483..380099) similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities SAKL0A04070g 1 380292 381002 ON 1 A04070 (380292..381002) similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein SAKL0A04092g 0 381231 386066 ON 1 A04092 complement(381231..386066) similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2 SAKL0A04114g 1 386331 387728 ON 1 A04114 (386331..387728) highly similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit SAKL0A04136g 0 387851 389176 ON 1 A04136 complement(387851..389176) similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit SAKL0A04158g 0 389395 391040 ON 1 A04158 complement(389395..390820,390889..391040) similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis intranuclear protein which exhibits a nucleotide-specific intron- dependent tRNA pseudouridine synthase activity SAKL0A04180g 1 391467 392012 ON 1 A04180 (391467..392012) highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis SAKL0A04202g 0 392142 394007 ON 1 A04202 complement(392142..394007) similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane SAKL0A04224g 1 394175 395896 ON 1 A04224 (394175..395896) similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function SAKL0A04246g 0 396019 397221 ON 1 A04246 complement(396019..397221) similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate SAKL0A04268g 1 397689 399419 ON 1 A04268 (397689..399419) similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W Hypothetical ORF SAKL0A04290g 1 399650 401971 ON 1 A04290 (399650..401971) highly similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W Hypothetical ORF SAKL0A04312g 0 402094 403320 ON 1 A04312 complement(402094..403320) conserved hypothetical protein SAKL0A04334g 1 403441 404946 ON 1 A04334 (403441..404946) similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2- PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation SAKL0A04356g 0 405004 406539 ON 1 A04356 complement(405004..406539) similar to gnl|GLV|YALI0C05643g Yarrowia lipolytica YALI0C05643g and some similarites with YGL066W uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex SAKL0A04378g 0 406830 407798 ON 1 A04378 complement(406830..407798) similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function SAKL0A04400g 0 408659 409711 ON 1 A04400 complement(408659..409711) similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes SAKL0A04422g 0 409833 410927 ON 1 A04422 complement(409833..410927) similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes SAKL0A04444g 1 412103 413527 ON 1 A04444 (412103..413527) highly similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta) SAKL0A04466g 1 413816 414937 ON 1 A04466 (413816..414937) highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit SAKL0A04488g 0 415344 415847 ON 1 A04488 complement(415344..415847) similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid SAKL0A04510g 1 416103 416471 ON 1 A04510 (416103..416471) highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site SAKL0A04532g 0 417310 419220 ON 1 A04532 complement(417310..419220) weakly similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability SAKL0A04554g 0 419835 421073 ON 1 A04554 complement(419835..421073) conserved hypothetical protein SAKL0A04576g 0 422093 423766 ON 1 A04576 complement(422093..423766) similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements SAKL0A04598g 1 424158 425864 ON 1 A04598 (424158..425864) similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane SAKL0A04620g 1 426819 427997 ON 1 A04620 (426819..427997) similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p SAKL0A04642g 0 428085 428861 ON 1 A04642 complement(428085..428861) similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF SAKL0A04686g 1 429728 431040 ON 1 A04686 (429728..429738,430082..430175,430411..431040) highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit SAKL0A04730g 1 432222 433847 ON 1 A04730 (432222..433847) similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co- regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol SAKL0A04752g 1 434100 435749 ON 1 A04752 (434100..435749) similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis SAKL0A04774g 1 435965 437671 ON 1 A04774 (435965..437671) uniprot|Q8NKG9 Saccharomyces kluyveri Putative delta 8- sphingolipid desaturase SAKL0A04796g 1 438053 438811 ON 1 A04796 (438053..438811) similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide SAKL0A04818g 0 438861 439595 ON 1 A04818 complement(438861..439595) similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF SAKL0A04840g 1 439951 440349 ON 1 A04840 (439951..440349) similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37 SAKL0A04862g 0 440467 442254 ON 1 A04862 complement(440467..442254) similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA- like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate SAKL0A04884g 0 442653 445439 ON 1 A04884 complement(442653..445439) similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex SAKL0A04906g 1 446435 447535 ON 1 A04906 (446435..447535) similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly SAKL0A04928g 0 447577 448014 ON 1 A04928 complement(447577..448014) conserved hypothetical protein SAKL0A04950g 0 448792 449937 ON 1 A04950 complement(448792..449937) some similarities with uniprot|P53156 Saccharomyces cerevisiae YGL081W Hypothetical ORF SAKL0A04972g 0 450224 451333 ON 1 A04972 complement(450224..451333) similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs SAKL0A04994g 0 451489 453390 ON 1 A04994 complement(451489..453390) similar to uniprot|Q08989 Saccharomyces cerevisiae YPL277C Hypothetical ORFs SAKL0A05016g 0 453967 456252 ON 1 A05016 complement(453967..456252) similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p Sklu_YGOB_Anc_6.192 0 457272 457466 ON 1 Anc_6.192 complement(457272..457466) ANNOTATED BY YGOB - SAKL0A05038g 0 458190 460628 ON 1 A05038 complement(458190..460628) similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant SAKL0A05060g 1 461875 462891 ON 1 A05060 (461875..462891) weakly similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases Sklu_1.trna2G 0 462973 463043 ON 1 tG-GCC complement(462973..463043) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0A05126g 1 463900 465639 ON 1 A05126 (463900..465639) uniprot|Q875R3 Saccharomyces kluyveri GUP1 SAKL0A05148g 0 465749 466573 ON 1 A05148 complement(465749..466573) similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF SAKL0A05170g 0 466816 468768 ON 1 A05170 complement(466816..468768) similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle- assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p SAKL0A05192g 1 468949 469450 ON 1 A05192 (468949..468959,469039..469450) highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Protein involved in error-free postreplication DNA repair forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity cooperates with chromatin-associated RING finger proteins Rad18p and Rad5p SAKL0A05214g 1 469847 471100 ON 1 A05214 (469847..471100) highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD( ) with lower specificity required for the response to oxidative stress SAKL0A05236g 1 472961 473338 ON 1 A05236 (472961..473338) uniprot|P06648 Saccharomyces kluyveri Mating factor alpha precursor SAKL0A05258g 0 473796 474560 ON 1 A05258 complement(473796..474560) similar to gnl|GLV|CAGL0G02849g Candida glabrata CAGL0G02849g and some similarites with YPL186C uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 SAKL0A05280g 0 475021 476769 ON 1 A05280 complement(475021..476769) similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF SAKL0A05302g 0 477373 477654 ON 1 A05302 complement(477373..477654) no similarity SAKL0A05324g 1 478502 479488 ON 1 A05324 (478502..479488) highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta SAKL0A05346g 0 479607 483635 ON 1 A05346 complement(479607..483635) similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex SAKL0A05368g 0 484027 487008 ON 1 A05368 complement(484027..487008) weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Protein required for accurate chromosome segregation localizes to the nuclear side of the spindle pole body forms a complex with YDR532C-P SAKL0A05390g 1 488570 488897 ON 1 A05390 (488570..488722,488826..488897) some similarities with uniprot|O14464 Saccharomyces cerevisiae YPL183W-A Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome SAKL0A05412g 0 489032 492025 ON 1 A05412 complement(489032..492025) similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF SAKL0A05434g 1 492312 495710 ON 1 A05434 (492312..495710) similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes SAKL0A05456g 0 496057 498189 ON 1 A05456 complement(496057..498189) similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One SAKL0A05478g 1 498526 500262 ON 1 A05478 (498526..500262) similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p SAKL0A05500g 0 500413 501624 ON 1 A05500 complement(500413..501624) weakly similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain SAKL0A05522g 1 502044 503483 ON 1 A05522 (502044..503483) similar to uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase null mutation enhances efficiency of translational suppressors Sklu_1.trna3E 0 503746 503817 ON 1 tE-UUC complement(503746..503817) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0A05588g 1 505510 506133 ON 1 A05588 (505510..506133) highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif SAKL0A05610g 0 506437 507399 ON 1 A05610 complement(506437..507399) some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin- dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription SAKL0A05632g 1 510446 512011 ON 1 A05632 (510446..512011) weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W Hypothetical ORF SAKL0A05654g 0 512449 514209 ON 1 A05654 complement(512449..514209) highly similar to uniprot|P38158 Saccharomyces cerevisiae YBR299W MAL32 Maltase (alpha-D-glucosidase) inducible protein involved in maltose catabolism encoded in the MAL3 complex locus functional in genomic reference strain S288C SAKL0A05676g 1 515333 517174 ON 1 A05676 (515333..517174) similar to uniprot|P53048 Saccharomyces cerevisiae YGR289C MAL11 Maltose permease inducible high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL1 complex locus member of the 12 transmembrane domain superfamily of sugar transporters SAKL0A05698g 1 518829 520589 ON 1 A05698 (518829..520589) highly similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C Hypothetical ORF SAKL0A05720g 1 521686 522792 ON 1 A05720 (521686..522792) highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase SAKL0A05742g 1 523680 525335 ON 1 A05742 (523680..525335) highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor SAKL0A05764g 0 525463 527040 ON 1 A05764 complement(525463..527040) highly similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p SAKL0A05786g 1 527329 528333 ON 1 A05786 (527329..528333) conserved hypothetical protein SAKL0A05808g 1 528556 529959 ON 1 A05808 (528556..529959) similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus SAKL0A05830g 0 531094 531942 ON 1 A05830 complement(531094..531942) similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability SAKL0A05874g 0 535011 536939 ON 1 A05874 complement(535011..536939) highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm SAKL0A05896g 0 537150 538289 ON 1 A05896 complement(537150..538289) similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF SAKL0A05918g 1 538498 541662 ON 1 A05918 (538498..541662) highly similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation SAKL0A05940g 0 541828 542346 ON 1 A05940 complement(541828..542346) highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor SAKL0A05962g 0 543144 544184 ON 1 A05962 complement(543144..544184) highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p SAKL0A05984g 1 544366 545706 ON 1 A05984 (544366..545706) highly similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin SAKL0A06006g 0 545827 546525 ON 1 A06006 complement(545827..546525) highly similar to uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF or YBR242W uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF SAKL0A06028g 0 547425 548395 ON 1 A06028 complement(547425..547825,548347..548395) highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein L29 of the large (60S) ribosomal subunit SAKL0A06050g 1 548837 550408 ON 1 A06050 (548837..550408) similar to uniprot|P38142 Saccharomyces cerevisiae YBR241C Hypothetical ORF SAKL0A06072g 1 551181 552518 ON 1 A06072 (551181..552518) similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes SAKL0A06094g 0 552634 553749 ON 1 A06094 complement(552634..553749) similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids SAKL0A06116g 1 554152 555684 ON 1 A06116 (554152..555684) similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF SAKL0A06138g 0 555907 556341 ON 1 A06138 complement(555907..556341) highly similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition SAKL0A06160g 1 557276 559210 ON 1 A06160 (557276..559210) similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF SAKL0A06182g 1 559732 560103 ON 1 A06182 (559732..560103) weakly similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0A06204g 0 560276 562807 ON 1 A06204 complement(560276..562807) similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family SAKL0A06226g 1 562951 564204 ON 1 A06226 (562951..564204) similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA SAKL0A06248g 0 564287 567685 ON 1 A06248 complement(564287..567685) similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF SAKL0A06270g 1 568021 569871 ON 1 A06270 (568021..569871) similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination SAKL0A06292g 0 569971 571320 ON 1 A06292 complement(569971..571320) similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis SAKL0A06314g 1 571580 572701 ON 1 A06314 (571580..572701) highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches SAKL0A06336g 0 572781 573026 ON 1 A06336 complement(572781..573026) similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore SAKL0A06358g 1 573150 574742 ON 1 A06358 (573150..574742) similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes SAKL0A06380g 0 574917 577028 ON 1 A06380 complement(574917..577028) similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1 SAKL0A06402g 1 577093 577389 ON 1 A06402 (577093..577389) no similarity SAKL0A06424g 0 578012 579349 ON 1 A06424 complement(578012..579349) similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W SAKL0A06446g 1 579445 580314 ON 1 A06446 (579445..580314) similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin SAKL0A06468g 0 580333 582531 ON 1 A06468 complement(580333..582531) similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters SAKL0A06490g 0 582736 583740 ON 1 A06490 complement(582736..583740) highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 involved in release from glucose repression invertase expression and sporulation associates with Snf1p SAKL0A06534g 0 584399 586162 ON 1 A06534 complement(584399..586162) similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase- promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate SAKL0A06556g 0 587223 588482 ON 1 A06556 complement(587223..588482) uniprot|Q760J0 Saccharomyces kluyveri Sk Omega-3 fatty acid desaturase SAKL0A06578g 0 588783 589685 ON 1 A06578 complement(588783..589685) conserved hypothetical protein Sklu_1.trna4W 1 591107 591210 ON 1 tW-CCA (591107..591142,591175..591210) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 60.83 SAKL0A06666g 1 591522 592460 ON 1 A06666 (591522..592460) conserved hypothetical protein SAKL0A06688g 0 592893 594617 ON 1 A06688 complement(592893..594236,594303..594617) similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis which in turn is required for respiratory growth SAKL0A06710g 1 594974 597286 ON 1 A06710 (594974..597286) highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome SAKL0A06732g 1 597802 598245 ON 1 A06732 (597802..598245) weakly similar to uniprot|P53130 Saccharomyces cerevisiae YGL121c GPG1 Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p involved in regulation of pseudohyphal growth SAKL0A06754g 1 598925 600394 ON 1 A06754 (598925..600394) similar to uniprot|Q75E99 Ashbya gossypii AAR178C AAR178Cp and some similarites with YGL122C uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA SAKL0A06776g 0 600940 601722 ON 1 A06776 complement(600940..601722) highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2 SAKL0A06798g 1 602690 603290 ON 1 A06798 (602690..602697,602768..603290) conserved hypothetical protein SAKL0A06820g 1 603815 605668 ON 1 A06820 (603815..605668) similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate SAKL0A06842g 0 605900 607324 ON 1 A06842 complement(605900..607324) weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 SAKL0A06864g 1 608439 611201 ON 1 A06864 (608439..611201) similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations SAKL0A06886g 0 611263 612189 ON 1 A06886 complement(611263..612189) similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p SAKL0A06908g 1 612325 613836 ON 1 A06908 (612325..613836) similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1 SAKL0A06930g 0 614198 616780 ON 1 A06930 complement(614198..616780) similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF SAKL0A06952g 0 618082 619890 ON 1 A06952 complement(618082..619890) highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10-methylenetetrahydrofolate to 5- methyltetrahydrofolate in the methionine biosynthesis pathway SAKL0A06974g 1 620230 622101 ON 1 A06974 (620230..622101) similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase SAKL0A06996g 1 622559 624166 ON 1 A06996 (622559..624166) highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60 SAKL0A07018g 1 624993 626081 ON 1 A07018 (624993..626081) highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex which is an evolutionarily- conserved multi-protein complex found in mitochondria SAKL0A07040g 1 627102 628748 ON 1 A07040 (627102..628748) similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF SAKL0A07062g 0 628851 630140 ON 1 A07062 complement(628851..630140) similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy SAKL0A07084g 1 630443 630829 ON 1 A07084 (630443..630829) highly similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription SAKL0A07106g 1 631418 631855 ON 1 A07106 (631418..631855) similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor SAKL0A07128g 1 632974 636495 ON 1 A07128 (632974..636495) highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase SAKL0A07150g 0 636624 637298 ON 1 A07150 complement(636624..637298) weakly similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis SAKL0A07172g 0 637807 638409 ON 1 A07172 complement(637807..638409) similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy SAKL0A07194g 1 638606 640756 ON 1 A07194 (638606..640756) similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2 SAKL0A07216g 0 640837 642645 ON 1 A07216 complement(640837..642554,642630..642645) similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes SAKL0A07238g 1 642699 644291 ON 1 A07238 (642699..644291) similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF SAKL0A07260g 1 644551 645145 ON 1 A07260 (644551..644592,644678..645145) highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N- end rule protein degradation (with Ubr1p) SAKL0A07282g 0 645325 646101 ON 1 A07282 complement(645325..646101) conserved hypothetical protein SAKL0A07304g 0 646374 647789 ON 1 A07304 complement(646374..647789) similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations SAKL0A07326g 1 648420 649862 ON 1 A07326 (648420..649862) uniprot|Q9HFB2 Saccharomyces kluyveri Sk Delta 9- fatty acid desaturase SAKL0A07348g 0 650070 650987 ON 1 A07348 complement(650070..650987) similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase SAKL0A07370g 0 652628 654100 ON 1 A07370 complement(652628..654100) weakly similar to uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein SAKL0A07392g 1 655412 656419 ON 1 A07392 (655412..656419) some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability SAKL0A07414g 0 656772 657179 ON 1 A07414 complement(656772..657179) highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud-site selection protein Axl2p to cell surface related to Drosophila cornichon Sklu_1.trna5E 0 657493 657564 ON 1 tE-UUC complement(657493..657564) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0A07480g 0 658699 660420 ON 1 A07480 complement(658699..660420) similar to uniprot|P38358 Saccharomyces cerevisiae YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane SAKL0A07502g 0 662822 663472 ON 1 A07502 complement(662822..663472) conserved hypothetical protein SAKL0A07524g 0 664236 664970 ON 1 A07524 complement(664236..664970) similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF SAKL0A07546g 0 665410 670134 ON 1 A07546 complement(665410..670134) weakly similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N- terminal domain that interacts with Sir4p and a C-terminal SNF2 domain SAKL0A07568g 0 670767 672086 ON 1 A07568 complement(670767..672086) uniprot|Q875R9 Saccharomyces kluyveri EXG1 Glucan 1,3- beta-glucosidase precursor Sklu_YGOB_Anc_6.98 0 672596 672832 ON 1 Anc_6.98 complement(672596..672832) ANNOTATED BY YGOB - Sklu_1.trna6E 1 673554 673625 ON 1 tE-UUC (673554..673625) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0A07612g 0 674027 677851 ON 1 A07612 complement(674027..677851) similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p-MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4 SAKL0A07634g 0 678039 679988 ON 1 A07634 complement(678039..679988) similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation SAKL0A07656g 0 680455 681750 ON 1 A07656 complement(680455..681750) highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans SAKL0A07678g 1 682072 682701 ON 1 A07678 (682072..682701) similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre-mRNA splicing Sklu_YGOB_Anc_6.93 0 683169 683456 ON 1 Anc_6.93 complement(683169..683456) ANNOTATED BY YGOB - SAKL0A07700g 1 684737 685090 ON 1 A07700 (684737..685090) similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0A07722g 1 686063 686929 ON 1 A07722 (686063..686929) conserved hypothetical protein SAKL0A07744g 1 688406 689050 ON 1 A07744 (688406..689050) highly similar to uniprot|P32835 Saccharomyces cerevisiae YLR293C GSP1 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport regulated by Prp20p Rna1p Yrb1p Yrb2p Yrp4p Yrb30p Cse1p and Kap95p yeast Gsp2p homolog SAKL0A07766g 1 689555 690133 ON 1 A07766 (689555..690133) similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER SAKL0A07788g 1 690785 691957 ON 1 A07788 (690785..691957) similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression SAKL0A07810g 1 692523 693371 ON 1 A07810 (692523..693371) similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C Hypothetical ORF SAKL0A07832g 0 693755 695686 ON 1 A07832 complement(693755..695686) highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function SAKL0A07854g 1 695833 697176 ON 1 A07854 (695833..697176) similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein SAKL0A07876g 0 697333 698517 ON 1 A07876 complement(697333..698517) highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase SAKL0A07898g 1 699072 699736 ON 1 A07898 (699072..699074,699548..699736) similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B and similar to uniprot|Q12087 Saccharomyces cerevisiae YLR287C-A RPS30A SAKL0A07920g 1 700299 701423 ON 1 A07920 (700299..701423) weakly similar to uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF SAKL0A07942g 0 701846 703810 ON 1 A07942 complement(701846..703810) similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP) SAKL0A07964g 1 705187 707364 ON 1 A07964 (705187..707364) similar to gnl|GLV|DEHA0G06655g Debaryomyces hansenii DEHA0G06655g and weakly similar to YLR286C uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p SAKL0A07986g 0 707624 708436 ON 1 A07986 complement(707624..708436) highly similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N- methyltransferase has a role in rDNA silencing and in lifespan determination SAKL0A08008g 1 709045 709899 ON 1 A08008 (709045..709899) similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl-CoA isomerase hexameric protein that converts 3-hexenoyl-CoA to trans-2- hexenoyl-CoA essential for the beta-oxidation of unsaturated fatty acids oleate-induced SAKL0A08030g 0 709996 710892 ON 1 A08030 complement(709996..710892) similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF SAKL0A08052g 1 711295 711765 ON 1 A08052 (711295..711765) similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF SAKL0A08074g 1 711985 715425 ON 1 A08074 (711985..715425) similar to uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate SAKL0A08096g 1 716182 718467 ON 1 A08096 (716182..718467) highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I) SAKL0A08118g 1 718720 720564 ON 1 A08118 (718720..720564) highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit SAKL0A08140g 0 721116 721538 ON 1 A08140 complement(721116..721437,721534..721538) similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 U1 snRNP protein of the Sm class SAKL0A08162g 0 721932 724385 ON 1 A08162 complement(721932..724385) highly similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W CDC46 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase SAKL0A08184g 1 725533 727902 ON 1 A08184 (725533..727902) weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis regulatory role also predicted for glucose repression and ion homeostasis potential Cdc28p substrate SAKL0A08206g 1 729465 731402 ON 1 A08206 (729465..731402) conserved hypothetical protein SAKL0A08228g 0 732518 734227 ON 1 A08228 complement(732518..734227) similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Member of drug-resistance protein family multicopy suppressor of gal11 null mutation SAKL0A08250g 1 734566 736671 ON 1 A08250 (734566..736671) weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance paralog of Yrr1p acting on an overlapping set of target genes Sklu_1.trna7V 1 738016 738089 ON 1 tV-AAC (738016..738089) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0A08360g 1 738393 741896 ON 1 A08360 (738393..741896) highly similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Protein required for accurate sister chromatid segregation SAKL0A08382g 0 741995 743164 ON 1 A08382 complement(741995..743164) highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase a mitochondrial inner membrane protein catalyzes the insertion of ferrous iron into protoporphyrin IX the eighth and final step in the heme biosynthetic pathway Yfh1p mediates the use of iron by Hem15p SAKL0A08404g 1 744212 746044 ON 1 A08404 (744212..746044) highly similar to gnl|GLV|KLLA0F20163g Kluyveromyces lactis KLLA0F20163g and similar to YOR175C uniprot|Q03130 Saccharomyces cerevisiae YOR175C Hypothetical ORF SAKL0A08426g 0 746101 747000 ON 1 A08426 complement(746101..747000) similar to gnl|GLV|KLLA0F20185g Kluyveromyces lactis KLLA0F20185g and weakly similar to YOR174W uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex SAKL0A08448g 0 747385 748434 ON 1 A08448 complement(747385..748434) similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Hypothetical ORF SAKL0A08470g 0 748600 749757 ON 1 A08470 complement(748600..749757) highly similar to uniprot|Q6Q5L1 Saccharomyces cerevisiae YLR270W DCS1 Non-essential hydrolase involved in mRNA decapping may function in a feedback mechanism to regulate deadenylation contains pyrophosphatase activity and a HIT (histidine triad) motif interacts with neutral trehalase Nth1p SAKL0A08492g 0 750118 750841 ON 1 A08492 complement(750118..750728,750808..750841) highly similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein assembles into SNARE complex with Bet1p Bos1p and Sed5p cycles between the ER and Golgi complex involved in anterograde and retrograde transport between the ER and Golgi synaptobrevin homolog SAKL0A08514g 1 752470 753363 ON 1 A08514 (752470..753363) conserved hypothetical protein SAKL0A08536g 1 754256 755929 ON 1 A08536 (754256..755929) similar to gnl|GLV|CAGL0K06105g Candida glabrata CAGL0K06105g and weakly similar to YLR267W uniprot|Q06150 Saccharomyces cerevisiae YLR267W BOP2 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation SAKL0A08558g 0 756256 758604 ON 1 A08558 complement(756256..758604) similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1 SAKL0A08580g 1 758763 759680 ON 1 A08580 (758763..759680) similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF SAKL0A08602g 0 759798 760340 ON 1 A08602 complement(759798..760340) highly similar to gnl|GLV|KLLA0F20273g Kluyveromyces lactis KLLA0F20273g and similar to YOR163W uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates SAKL0A08624g 0 760502 762346 ON 1 A08624 complement(760502..762346) no similarity SAKL0A08646g 1 763735 764220 ON 1 A08646 (763735..764220) no similarity SAKL0A08668g 0 764300 765739 ON 1 A08668 complement(764300..765739) similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF SAKL0A08690g 1 767160 767951 ON 1 A08690 (767160..767951) similar to uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches SAKL0A08712g 0 767998 768356 ON 1 A08712 complement(767998..768255,768321..768356) highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment SAKL0A08734g 1 769401 770214 ON 1 A08734 (769401..769529,769927..770214) highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit SAKL0A08756g 0 770525 772303 ON 1 A08756 complement(770525..772303) similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation contains a TFIIS-like domain and a PHD finger multicopy suppressor of temperature-sensitive ess1 mutations probably binds RNA polymerase II large subunit SAKL0A08778g 1 772659 773918 ON 1 A08778 (772659..773918) highly similar to gnl|GLV|KLLA0B13387g Kluyveromyces lactis KLLA0B13387g and similar to YKL004W uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance SAKL0A08800g 0 774249 774638 ON 1 A08800 complement(774249..774638) similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator SAKL0A08822g 1 774870 775697 ON 1 A08822 (774870..774929,775006..775227,775290..775697) highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT- III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis SAKL0A08844g 0 775775 776438 ON 1 A08844 complement(775775..776258,776326..776438) similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism Sklu_CEN1 1 777082 777277 ON 1 CEN1 (777082..777277) Chromosome I centromere SAKL0A08888g 0 777534 779606 ON 1 A08888 complement(777534..779606) highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p SAKL0A08910g 1 780195 782006 ON 1 A08910 (780195..782006) highly similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs SAKL0A08932g 1 782815 784176 ON 1 A08932 (782815..784176) highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability SAKL0A08954g 0 784288 785554 ON 1 A08954 complement(784288..785180,785236..785554) similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function SAKL0A08976g 0 785625 787151 ON 1 A08976 complement(785625..787151) no similarity SAKL0A08998g 1 787711 789648 ON 1 A08998 (787711..789648) conserved hypothetical protein SAKL0A09020g 0 789823 790566 ON 1 A09020 complement(789823..790566) similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation SAKL0A09042g 1 790745 791392 ON 1 A09042 (790745..791392) similar to uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1 SAKL0A09064g 1 792006 793661 ON 1 A09064 (792006..793661) similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling Sklu_1.trna8H 1 795178 795249 ON 1 tH-GUG (795178..795249) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 SAKL0A09152g 1 796854 798224 ON 1 A09152 (796854..798224) similar to similar to uniprot|P27810 Saccharomyces cerevisiae YOR099w KTR1 mannosyltransferase and to uniprot|P27809 Saccharomyces cerevisiae YDR483w KRE2 SAKL0A09174g 1 798428 798818 ON 1 A09174 (798428..798436,798591..798818) similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex SAKL0A09196g 0 799345 802032 ON 1 A09196 complement(799345..802032) highly similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3- hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities SAKL0A09218g 0 802348 803843 ON 1 A09218 complement(802348..803734,803809..803843) similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain SAKL0A09240g 1 804106 806220 ON 1 A09240 (804106..806220) some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex SAKL0A09262g 1 807106 807984 ON 1 A09262 (807106..807984) similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification SAKL0A09284g 0 808041 808931 ON 1 A09284 complement(808041..808931) highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family SAKL0A09306g 1 809606 810646 ON 1 A09306 (809606..810646) similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized SAKL0A09328g 0 810821 812155 ON 1 A09328 complement(810821..812155) similar to uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF SAKL0A09350g 0 812443 813792 ON 1 A09350 complement(812443..813792) similar to uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening SAKL0A09372g 1 814740 816869 ON 1 A09372 (814740..816869) similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids SAKL0A09394g 0 817374 819767 ON 1 A09394 complement(817374..819767) highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family SAKL0A09416g 0 820552 821709 ON 1 A09416 complement(820552..821709) similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation SAKL0A09438g 0 823711 825036 ON 1 A09438 complement(823711..825036) weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0A09460g 1 826395 827117 ON 1 A09460 (826395..827117) weakly similar to uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl-transferase involved in acetylation of the N-terminal residues of histones H4 and H2A SAKL0A09482g 1 831930 833096 ON 1 A09482 (831930..833096) some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes SAKL0A09504g 0 833526 834105 ON 1 A09504 complement(833526..833958,834035..834105) highly similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein SAKL0A09526g 1 834338 836326 ON 1 A09526 (834338..836326) conserved hypothetical protein SAKL0A09548g 1 836614 838215 ON 1 A09548 (836614..836704,837212..838215) similar to uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b SAKL0A09570g 0 838406 839041 ON 1 A09570 complement(838406..839041) similar to gnl|GLV|CAGL0K03069g Candida glabrata CAGL0K03069g and weakly similar to YMR073C uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF SAKL0A09592g 0 839689 841749 ON 1 A09592 complement(839689..841749) conserved hypothetical protein SAKL0A09614g 0 842058 842521 ON 1 A09614 complement(842058..842358,842430..842521) similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF SAKL0A09636g 1 843781 845715 ON 1 A09636 (843781..845715) similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function SAKL0A09658g 0 845925 849785 ON 1 A09658 complement(845925..849785) similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold SAKL0A09680g 0 850036 852159 ON 1 A09680 complement(850036..852159) similar to uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF SAKL0A09702g 0 852429 855539 ON 1 A09702 complement(852429..855539) similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm. SAKL0A09724g 0 855698 857353 ON 1 A09724 complement(855698..857353) similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance" SAKL0A09746g 1 858392 860038 ON 1 A09746 (858392..860038) similar to uniprot|P38748 Saccharomyces cerevisiae YHL010C Hypothetical ORF SAKL0A09768g 1 860675 861637 ON 1 A09768 (860675..861637) highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes SAKL0A09790g 0 861792 862463 ON 1 A09790 complement(861792..862463) conserved hypothetical protein SAKL0A09812g 0 863141 865396 ON 1 A09812 complement(863141..865396) similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase SAKL0A09834g 0 865888 867387 ON 1 A09834 complement(865888..867387) highly similar to uniprot|P32861 Saccharomyces cerevisiae YKL035W UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase EC:2.7.7.9 SAKL0A09856g 0 867959 871021 ON 1 A09856 complement(867959..871021) some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor Sklu_1.trna9M 1 871414 871485 ON 1 tM-CAU (871414..871485) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.91 SAKL0A09900g 1 872323 873282 ON 1 A09900 (872323..873282) similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF SAKL0A09922g 1 873740 875032 ON 1 A09922 (873740..875032) similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1 SAKL0A09966g 0 875881 876237 ON 1 A09966 complement(875881..876237) similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20 SAKL0A09988g 1 876896 878215 ON 1 A09988 (876896..878215) conserved hypothetical protein SAKL0A10010g 1 878885 881044 ON 1 A10010 (878885..881044) similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway SAKL0A10032g 0 881186 882691 ON 1 A10032 complement(881186..882691) similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein SAKL0A10054g 0 883701 883895 ON 1 A10054 complement(883701..883895) conserved hypothetical protein SAKL0A10076g 1 886393 887856 ON 1 A10076 (886393..887856) similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C SNG1 Protein involved in nitrosoguanidine resistance and weakly similar to YJR015W uniprot|P47090 Saccharomyces cerevisiae YJR015W Hypothetical ORF SAKL0A10098g 0 888301 888570 ON 1 A10098 complement(888301..888570) conserved hypothetical protein SAKL0A10120g 0 889415 891247 ON 1 A10120 complement(889415..891247) conserved hypothetical protein SAKL0A10142g 0 891645 892340 ON 1 A10142 complement(891645..892340) weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA involved in RNA splicing Sklu_1.trna10T 1 892479 892550 ON 1 tT-CGU (892479..892550) tRNA Type: Thr (T) | Anti-Codon: CGU | Cove Score: 76.93 SAKL0A10186g 0 892896 893555 ON 1 A10186 complement(892896..893555) similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene- fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis SAKL0A10208g 1 894334 898266 ON 1 A10208 (894334..898266) similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells SAKL0A10230g 0 898613 901663 ON 1 A10230 complement(898613..901663) highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability SAKL0A10252g 1 901837 902466 ON 1 A10252 (901837..902466) similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p SAKL0A10274g 1 902542 903831 ON 1 A10274 (902542..903831) similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1- 371 allele SAKL0A10318g 0 904386 905618 ON 1 A10318 complement(904386..905618) similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM SAKL0A10340g 0 905875 906174 ON 1 A10340 complement(905875..906174) no similarity SAKL0A10362g 1 906863 908335 ON 1 A10362 (906863..908335) highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) SAKL0A10384g 0 908415 910298 ON 1 A10384 complement(908415..910298) similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion SAKL0A10406g 1 910452 912587 ON 1 A10406 (910452..912587) similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin- mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase SAKL0A10428g 1 913001 913480 ON 1 A10428 (913001..913480) similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus SAKL0A10450g 0 913811 914734 ON 1 A10450 complement(913811..914734) highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions SAKL0A10472g 1 916403 917776 ON 1 A10472 (916403..917776) similar to uniprot|Q04638 Saccharomyces cerevisiae YML068W ITT1 Protein that modulates the efficiency of translation termination interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro contains a zinc finger domain characteristic of the TRIAD class of proteins SAKL0A10516g 0 923043 924656 ON 1 A10516 complement(923043..924656) some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins SAKL0A10538g 0 925663 927210 ON 1 A10538 complement(925663..927210) conserved hypothetical protein SAKL0A10560g 1 928213 929442 ON 1 A10560 (928213..929442) similar to gnl|GLV|KLLA0F00638g Kluyveromyces lactis KLLA0F00638g and weakly similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C SAKL0A10582g 0 930343 931209 ON 1 A10582 complement(930343..931209) conserved hypothetical protein SAKL0A10604g 0 931594 931911 ON 1 A10604 complement(931594..931911) no similarity SAKL0A10626g 0 932879 933841 ON 1 A10626 complement(932879..933841) similar to uniprot|P36007 Saccharomyces cerevisiae YKL218C SRY1 3-hydroxyaspartate dehydratase deaminates L- threo-3-hydroxyaspartate to form oxaloacetate and ammonia required for survival in the presence of hydroxyaspartate SAKL0A10648g 1 934819 935604 ON 1 A10648 (934819..935604) some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0A10670g 1 937609 938538 ON 1 A10670 (937609..938538) similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family SAKL0B00110g 1 74 1036 ON 2 B00110 (74..1036) no similarity SAKL0B00132g 0 2963 3262 ON 2 B00132 complement(2963..3262) conserved hypothetical protein SAKL0B00154g 0 5697 6476 ON 2 B00154 complement(5697..6476) conserved hypothetical protein SAKL0B00176g 0 10584 11624 ON 2 B00176 complement(10584..11624) similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W Oxidoreductase SAKL0B00198g 0 12734 13039 ON 2 B00198 complement(12734..13039) no similarity SAKL0B00220g 1 15772 17409 ON 2 B00220 (15772..17409) similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 SAKL0B00242g 0 18815 19114 ON 2 B00242 complement(18815..19114) some similarities with uniprot|Q12198 Saccharomyces cerevisiae YLL058W Hypothetical ORF SAKL0B00264g 1 22039 23598 ON 2 B00264 (22039..23598) similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W RGT2 Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes SAKL0B00286g 0 24865 25764 ON 2 B00286 complement(24865..25764) similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF SAKL0B00308g 0 30301 31962 ON 2 B00308 complement(30301..31962) similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane SAKL0B00440g 1 47548 48354 ON 2 B00440 (47548..48354) similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH SAKL0B00462g 1 49519 50604 ON 2 B00462 (49519..50604) similar to uniprot|P47180 Saccharomyces cerevisiae YJR153W PGU1 Endo-polygalacturonase pectolytic enzyme that hydrolyzes the alpha-1 4-glycosidic bonds in the rhamnogalacturonan chains in pectins SAKL0B00484g 1 51813 53378 ON 2 B00484 (51813..53378) similar to uniprot|P43554 Saccharomyces cerevisiae YFL049W Hypothetical ORF SAKL0B00506g 0 53479 54777 ON 2 B00506 complement(53479..54777) similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport SAKL0B00528g 0 54959 55363 ON 2 B00528 complement(54959..55363) conserved hypothetical protein SAKL0B00550g 1 55549 57729 ON 2 B00550 (55549..57729) similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p SAKL0B00572g 0 57801 58712 ON 2 B00572 complement(57801..58712) similar to uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 P40 inhibitor of Cdc28p-Clb5p protein kinase complex SAKL0B00594g 1 59062 59828 ON 2 B00594 (59062..59064,59124..59828) similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor) localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi SAKL0B00616g 0 59862 61643 ON 2 B00616 complement(59862..61643) similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 The authentic non-tagged protein was localized to the mitochondria SAKL0B00638g 1 61811 62449 ON 2 B00638 (61811..62449) highly similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 The authentic non-tagged protein was localized to the mitochondria SAKL0B00660g 0 62679 63446 ON 2 B00660 complement(62679..63446) highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 involved in synthesis of GDP- mannose and dolichol-phosphate-mannose required for protein assembly in endoplasmic reticulum phosphomannomutase SAKL0B00682g 0 63911 64573 ON 2 B00682 complement(63911..64573) highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W SAKL0B00704g 1 65060 65569 ON 2 B00704 (65060..65569) highly similar to gnl|GLV|KLLA0D05621g Kluyveromyces lactis KLLA0D05621g and similar to YLR074C uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0B00726g 0 65636 66583 ON 2 B00726 complement(65636..66583) similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C YOD1 Yeast OTU Deubiquitinating enzyme 1 SAKL0B00748g 1 66886 67479 ON 2 B00748 (66886..67479) similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C Hypothetical ORF SAKL0B00770g 0 67494 70085 ON 2 B00770 complement(67494..70085) similar to uniprot|P43560 Saccharomyces cerevisiae YFL042C Due to a sequence change (deletion of G at 46151) YFL043C is now part of YFL042C. SAKL0B00792g 1 70679 73624 ON 2 B00792 (70679..73624) similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Component of RNA polymerase II holoenzyme/mediator complex affects chromatin structure and transcriptional regulation of diverse genes required for glucose repression HO repression RME1 repression and sporulation SAKL0B00814g 1 74565 75629 ON 2 B00814 (74565..75629) similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase expression is induced in the presence of sorbitol SAKL0B00836g 1 76933 78780 ON 2 B00836 (76933..78780) similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W SAKL0B00858g 1 80047 82332 ON 2 B00858 (80047..82332) highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 mitochondrial elongation factor G- like protein SAKL0B00880g 0 82514 82954 ON 2 B00880 complement(82514..82954) similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts SAKL0B00902g 1 83877 86711 ON 2 B00902 (83877..86711) similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA also influences stability of intron-containing COX1 primary transcripts located in the mitochondrial inner membrane SAKL0B00924g 0 86855 87506 ON 2 B00924 complement(86855..87293,87355..87506) similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N- terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 SAKL0B00946g 1 87829 89412 ON 2 B00946 (87829..89412) similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W Hypothetical ORF SAKL0B00968g 0 89966 91533 ON 2 B00968 complement(89966..91083,91524..91533) highly similar to uniprot|P02579 Saccharomyces cerevisiae YFL039C ACT1 Actin SAKL0B00990g 1 91838 92359 ON 2 B00990 (91838..92359) similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Hypothetical ORF SAKL0B01012g 0 92466 93080 ON 2 B01012 complement(92466..93080) highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Ras-like small GTPase involved in the ER-to-Golgi step of the secretory pathway complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) SAKL0B01034g 0 93513 94298 ON 2 B01034 complement(93513..94298) similar to uniprot|Q12144 Saccharomyces cerevisiae YLR064W Hypothetical ORF SAKL0B01056g 1 95237 96793 ON 2 B01056 (95237..95248,95456..96793) highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin associates with alpha- tubulin (Tub1p and Tub3p) to form tubulin dimer which polymerizes to form microtubules SAKL0B01078g 1 97198 101106 ON 2 B01078 (97198..101106) similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W SAKL0B01100g 0 101295 102197 ON 2 B01100 complement(101295..102087,102175..102197) similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein SAKL0B01122g 0 102399 103412 ON 2 B01122 complement(102399..103412) similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Hypothetical ORF SAKL0B01144g 0 103941 104515 ON 2 B01144 complement(103941..104288,104504..104515) similar to uniprot|P05749 Saccharomyces cerevisiae YLR061W SAKL0B01166g 1 104939 107797 ON 2 B01166 (104939..107797) similar to uniprot|P43564 Saccharomyces cerevisiae YFL034W Possible integral membrane protein that interacts with Rpp0p which is a component of the ribosomal stalk SAKL0B01188g 0 107923 109710 ON 2 B01188 complement(107923..109710) highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate the active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar SAKL0B01210g 0 109892 114658 ON 2 B01210 complement(109892..114658) similar to uniprot|Q75BQ3 Ashbya gossypii ACR218W ACR218Wp and some similarites with YFL033C uniprot|P43565 Saccharomyces cerevisiae YFL033C RIM15 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients specifically the establishment of stationary phase originally identified as a regulator of IME2 SAKL0B01232g 1 115978 116946 ON 2 B01232 (115978..116946) similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 RNA exonuclease required for U4 snRNA maturation functions redundantly with Rnh70p in 5.8S rRNA maturation and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases SAKL0B01254g 1 117546 118220 ON 2 B01254 (117546..118220) weakly similar to uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response via UPRE binding and membrane biogenesis ER stress-induced splicing pathway utilizing Ire1p Trl1p and Ada5p facilitates efficient Hac1p synthesis SAKL0B01276g 1 119226 120104 ON 2 B01276 (119226..120104) conserved hypothetical protein SAKL0B01298g 1 120401 121516 ON 2 B01298 (120401..121516) similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W SAKL0B01320g 1 122306 123715 ON 2 B01320 (122306..123715) highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 serine hydroxymethyltransferase SAKL0B01342g 1 126269 127117 ON 2 B01342 (126269..127117) conserved hypothetical protein SAKL0B01364g 0 127857 130244 ON 2 B01364 complement(127857..130244) similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Hypothetical ORF SAKL0B01386g 1 131741 132901 ON 2 B01386 (131741..132901) some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation SAKL0B01408g 1 134109 134885 ON 2 B01408 (134109..134885) some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation SAKL0B01430g 1 138546 138941 ON 2 B01430 (138546..138941) no similarity SAKL0B01452g 1 139873 141255 ON 2 B01452 (139873..141255) conserved hypothetical protein Sklu_YGOB_Kwal_14.1254 1 145407 145667 ON 2 Kwal_14.1254 (145407..145667) ANNOTATED BY YGOB - SAKL0B01474g 0 145734 146777 ON 2 B01474 complement(145734..146777) similar to uniprot|P43568 Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle phosphorylates and activates Cdc28p nucleotide-binding pocket differs significantly from those of most other protein kinases SAKL0B01496g 0 147169 148266 ON 2 B01496 complement(147169..148266) similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase catalyzes the introduction of a C-5(6) double bond into episterol a precursor in ergosterol biosynthesis mutants are viable but cannot grow on non-fermentable carbon sources SAKL0B01518g 0 148745 149542 ON 2 B01518 complement(148745..149542) similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of the evolutionarily-conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation putative ABC ATPase interacts with Ssn2p Ssn3p and Ssn8p SAKL0B01540g 1 150043 151752 ON 2 B01540 (150043..151752) similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA required for SAGA-mediated inhibition at some promoters SAKL0B01562g 0 151883 153451 ON 2 B01562 complement(151883..153451) similar to uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p Ypt31p and Ypt32p involved in the regulation of ER to Golgi vesicle transport SAKL0B01584g 1 153832 155208 ON 2 B01584 (153832..155208) uniprot|P12384 Saccharomyces kluyveri STE2 Pheromone alpha factor receptor SAKL0B01606g 0 155482 158619 ON 2 B01606 complement(155482..158619) similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules SAKL0B01628g 0 159210 161591 ON 2 B01628 complement(159210..161591) similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb Sklu_YGOB_BUD27 1 162384 165238 ON 2 BUD27 (162384..163391,163394..165238) ANNOTATED BY YGOB - skipping over 1 frameshift Sklu_YGOB_Anc_8.48 1 163790 165238 OFF 2 Anc_8.48 (163790..165238) ANNOTATED BY YGOB - SAKL0B01672g 1 166048 167253 ON 2 B01672 (166048..167253) conserved hypothetical protein SAKL0B01694g 1 168346 170151 ON 2 B01694 (168346..170151) some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall SAKL0B01716g 1 171590 172186 ON 2 B01716 (171590..172186) conserved hypothetical protein SAKL0B01738g 0 172491 173990 ON 2 B01738 complement(172491..173990) highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C SAKL0B01760g 0 174463 175086 ON 2 B01760 complement(174463..175086) weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex SAKL0B01782g 0 175966 176679 ON 2 B01782 complement(175966..176679) similar to uniprot|Q2JS25 Yellowstone A-Prime) CYA_2439 ISSoc2 resolvase SAKL0B01804g 1 177009 177698 ON 2 B01804 (177009..177698) similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability SAKL0B01826g 1 179191 181242 ON 2 B01826 (179191..181242) some similarities with uniprot|P43574 Saccharomyces cerevisiae YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression member of the GATA family of DNA binding proteins activity and localization regulated by nitrogen limitation and Ure2p SAKL0B01848g 1 182006 184852 ON 2 B01848 (182006..184852) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0B01870g 1 185897 188926 ON 2 B01870 (185897..188926) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis Sklu_2.trna1A 1 191463 191535 ON 2 tA-AGC (191463..191535) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0B01958g 0 191750 193249 ON 2 B01958 complement(191750..193249) highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi- enzyme complexes SAKL0B01980g 1 195604 195928 ON 2 B01980 (195604..195630,195725..195928) highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2 SAKL0B02002g 0 196063 196551 ON 2 B02002 complement(196063..196551) similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6- phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA SAKL0B02024g 0 196790 198187 ON 2 B02024 complement(196790..198187) weakly similar to uniprot|Q12110 Saccharomyces cerevisiae YLR049C Hypothetical ORF SAKL0B02046g 0 198419 198928 ON 2 B02046 complement(198419..198928) similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF SAKL0B02068g 0 199274 200806 ON 2 B02068 complement(199274..200806) some similarities with uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones SAKL0B02090g 1 201410 201766 ON 2 B02090 (201410..201766) highly similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras-Pka pathways SAKL0B02112g 0 202102 203685 ON 2 B02112 complement(202102..203685) weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260w TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para- aminobenzoate (PABA) SAKL0B02134g 1 204250 205236 ON 2 B02134 (204250..205236) weakly similar to uniprot|Q02732 Saccharomyces cerevisiae YPL018W CTF19 Outer kinetochore protein, required for accurate mitotic chromosome segregation; forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex SAKL0B02156g 0 205340 207145 ON 2 B02156 complement(205340..207145) similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex SAKL0B02178g 0 208306 208902 ON 2 B02178 complement(208306..208902) weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1) SAKL0B02200g 0 209441 210553 ON 2 B02200 complement(209441..210553) conserved hypothetical protein SAKL0B02222g 0 210922 211323 ON 2 B02222 complement(210922..211323) no similarity SAKL0B02244g 1 212226 214547 ON 2 B02244 (212226..214547) similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p SAKL0B02266g 1 215026 215451 ON 2 B02266 (215026..215451) conserved hypothetical protein SAKL0B02288g 1 215750 219436 ON 2 B02288 (215750..219436) similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure SAKL0B02310g 1 219787 226200 ON 2 B02310 (219787..226200) similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage SAKL0B02332g 1 227078 227719 ON 2 B02332 (227078..227719) highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane SAKL0B02354g 1 228276 229238 ON 2 B02354 (228276..229238) conserved hypothetical protein similar to S. cerevisiae YDR356w SAKL0B02376g 1 229571 232111 ON 2 B02376 (229571..232111) similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative) SAKL0B02398g 1 232567 234300 ON 2 B02398 (232567..234300) similar to uniprot|Q750H2 Ashbya gossypii AGL019W AGL019Wp and weakly similar to YPL020C uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase SAKL0B02420g 0 234642 237341 ON 2 B02420 complement(234642..237341) similar to uniprot|P40965 Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination required for normal levels of crossing over colocalizes with Zip2p to discrete foci on meiotic chromosomes has homology to bacterial MutS protein SAKL0B02442g 0 237362 238288 ON 2 B02442 complement(237362..238288) similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD( )-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD( )-dependent histone deacetylase activity in vitro Sklu_2.trna2N 0 239271 239344 ON 2 tN-GUU complement(239271..239344) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0B02508g 1 240170 243307 ON 2 B02508 (240170..243307) similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF SAKL0B02530g 0 243445 244035 ON 2 B02530 complement(243445..244035) highly similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER SAKL0B02552g 1 244283 245374 ON 2 B02552 (244283..245374) similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation SAKL0B02574g 0 245678 249343 ON 2 B02574 complement(245678..249343) similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift SAKL0B02596g 1 249614 249973 ON 2 B02596 (249614..249973) highly similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit SAKL0B02618g 0 250101 251468 ON 2 B02618 complement(250101..251468) similar to uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF SAKL0B02640g 0 252031 253182 ON 2 B02640 complement(252031..253182) conserved hypothetical protein SAKL0B02662g 1 253458 255962 ON 2 B02662 (253458..255962) similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W SAKL0B02684g 0 256014 257759 ON 2 B02684 complement(256014..257759) similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90 SAKL0B02706g 1 257938 261474 ON 2 B02706 (257938..261474) similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein SAKL0B02728g 1 261818 263611 ON 2 B02728 (261818..263611) similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex SAKL0B02750g 0 264001 264939 ON 2 B02750 complement(264001..264939) highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p SAKL0B02772g 1 265167 266582 ON 2 B02772 (265167..266582) similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation SAKL0B02794g 0 266645 268441 ON 2 B02794 complement(266645..268441) highly similar to gnl|GLV|KLLA0E14410g Kluyveromyces lactis KLLA0E14410g and similar to YFL002C uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP- dependent RNA helicase SAKL0B02816g 1 268632 269945 ON 2 B02816 (268632..269945) similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm SAKL0B02838g 0 270015 270728 ON 2 B02838 complement(270015..270728) highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression SAKL0B02860g 1 270894 272093 ON 2 B02860 (270894..272093) similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double- strand break repair Sklu_CEN2 1 272171 272366 ON 2 CEN2 (272171..272366) Chromosome II centromere SAKL0B02904g 1 272783 273403 ON 2 B02904 (272783..273403) similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro SAKL0B02926g 1 273721 275148 ON 2 B02926 (273721..275148) highly similar to uniprot|P43635 Saccharomyces cerevisiae YPR001W CIT3 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate mitochondrial isozyme involved in the TCA cycle SAKL0B02948g 1 275684 277258 ON 2 B02948 (275684..277258) highly similar to uniprot|Q12428 Saccharomyces cerevisiae YPR002W PDH1 Mitochondrial protein that participates in respiration induced by diauxic shift homologous to E. coli PrpD may take part in the conversion of 2-methylcitrate to 2-methylisocitrate SAKL0B02970g 1 278150 280699 ON 2 B02970 (278150..280699) highly similar to uniprot|Q750F1 Ashbya gossypii AGR004W AGR004Wp and similar to YFR002W uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p SAKL0B02992g 0 280793 281275 ON 2 B02992 complement(280793..281275) weakly similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen SAKL0B03014g 1 281478 282410 ON 2 B03014 (281478..282410) highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates SAKL0B03036g 0 282513 283931 ON 2 B03036 complement(282513..283931) similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle SAKL0B03058g 1 284125 285684 ON 2 B03058 (284125..285684) similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF Sklu_2.trna3F 0 286142 286234 ON 2 tF-GAA complement(286142..286177,286198..286234) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.42 SAKL0B03124g 0 288006 290240 ON 2 B03124 complement(288006..290240) similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF SAKL0B03146g 0 290689 291711 ON 2 B03146 complement(290689..291711) similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C Hypothetical ORF SAKL0B03168g 1 292081 293157 ON 2 B03168 (292081..293157) similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W Hypothetical ORF SAKL0B03190g 0 293232 294773 ON 2 B03190 complement(293232..294773) no similarity SAKL0B03212g 0 295359 297053 ON 2 B03212 complement(295359..297053) similar to uniprot|Q12031 Saccharomyces cerevisiae YPR006C ICL2 2-methylisocitrate lyase of the mitochondrial matrix functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate ICL2 transcription is repressed by glucose and induced by ethanol SAKL0B03234g 0 298143 300248 ON 2 B03234 complement(298143..300248) similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex maintains cohesion between sister chromatids during meiosis I maintains cohesion between centromeres of sister chromatids until meiosis II homolog of S. pombe Rec8p SAKL0B03256g 1 300489 301064 ON 2 B03256 (300489..301064) similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far8p Far9p Far10p and Far11p Sklu_2.trna4G 1 303067 303137 ON 2 tG-GCC (303067..303137) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0B03322g 1 304015 305139 ON 2 B03322 (304015..305139) similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron SAKL0B03344g 1 307830 309686 ON 2 B03344 (307830..309686) weakly similar to uniprot|Q12753 Saccharomyces cerevisiae YPR008W SAKL0B03366g 0 309914 311203 ON 2 B03366 complement(309914..311203) similar to uniprot|P53107 Saccharomyces cerevisiae YGL164C YRB30 Competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) able to form trimeric complexes with RanGTP and some of the karyopherins inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran. SAKL0B03388g 0 311330 314008 ON 2 B03388 complement(311330..314008) highly similar to gnl|GLV|KLLA0A03069g Kluyveromyces lactis KLLA0A03069g and similar to YGL163C uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA- dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis member of the SWI/SNF family SAKL0B03410g 0 314076 314495 ON 2 B03410 complement(314076..314495) no similarity SAKL0B03432g 1 314631 315527 ON 2 B03432 (314631..315527) some similarities with uniprot|Q12286 Saccharomyces cerevisiae YPR009W SUT2 Involved in sterol uptake homologous to SUT1 SAKL0B03454g 0 315736 316608 ON 2 B03454 complement(315736..316608) weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases computational analysis of large-scale protein- protein interaction data suggests a possible role in vesicle-mediated transport Sklu_2.trna5G 0 317013 317083 ON 2 tG-GCC complement(317013..317083) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0B03498g 1 318206 319420 ON 2 B03498 (318206..319420) similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Protein required for respiratory growth null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start SAKL0B03520g 0 319480 322299 ON 2 B03520 complement(319480..322299) highly similar to uniprot|P13586 Saccharomyces cerevisiae YGL167C PMR1 High affinity Ca2 /Mn2 P-type ATPase required for Ca2 and Mn2 transport into Golgi involved in Ca2 dependent protein sorting and processing mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease SAKL0B03542g 0 322739 326332 ON 2 B03542 complement(322739..326332) highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135 Sklu_2.trna6K 1 327203 327275 ON 2 tK-CUU (327203..327275) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0B03586g 1 327926 328972 ON 2 B03586 (327926..328972) some similarities with gnl|GLV|KLLA0A03201g Kluyveromyces lactis KLLA0A03201g and some similarites with YMR305C uniprot|Q04951 Saccharomyces cerevisiae SAKL0B03608g 1 329534 330592 ON 2 B03608 (329534..330592) some similarities with uniprot|P36027 Saccharomyces cerevisiae YLR332W MID2 Protein required for mating Sklu_2.trna7D 1 334062 334133 ON 2 tD-GUC (334062..334133) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0B03674g 1 334446 335579 ON 2 B03674 (334446..335579) conserved hypothetical protein SAKL0B03696g 0 335580 336362 ON 2 B03696 complement(335580..336362) highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes SAKL0B03718g 1 336496 337320 ON 2 B03718 (336496..337320) similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0B03806g 0 338312 338638 ON 2 B03806 complement(338312..338638) similar to uniprot|P07282 Saccharomyces cerevisiae YLR333C Sklu_2.trna8E 1 340197 340268 ON 2 tE-UUC (340197..340268) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0B03850g 1 340435 342429 ON 2 B03850 (340435..342429) weakly similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization SAKL0B03872g 0 342546 345728 ON 2 B03872 complement(342546..345728) similar to uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway SAKL0B03894g 1 345902 346978 ON 2 B03894 (345902..346978) highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane- spanning ATPase SAKL0B03916g 1 347140 347835 ON 2 B03916 (347140..347222,347304..347835) similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space has a role in the maturation of cytosolic iron-sulfur proteins ortholog of human hepatopoietin (ALR) SAKL0B03938g 0 348032 350260 ON 2 B03938 complement(348032..350260) weakly similar to uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin Sklu_2.trna9D 1 351596 351667 ON 2 tD-GUC (351596..351667) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0B04004g 0 351924 353414 ON 2 B04004 complement(351924..353414) conserved hypothetical protein SAKL0B04026g 0 354862 355416 ON 2 B04026 complement(354862..355416) similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0B04048g 0 357788 358240 ON 2 B04048 complement(357788..358240) no similarity SAKL0B04070g 0 361434 362558 ON 2 B04070 complement(361434..362558) conserved hypothetical protein SAKL0B04092g 1 364520 365458 ON 2 B04092 (364520..365458) highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 SAKL0B04114g 1 365887 368166 ON 2 B04114 (365887..368166) conserved hypothetical protein SAKL0B04136g 1 368526 369602 ON 2 B04136 (368526..369602) similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF SAKL0B04158g 1 370872 376583 ON 2 B04158 (370872..376583) highly similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 Catalytic subunit of 1 3-beta-D- glucan synthase functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling SAKL0B04180g 1 377041 378669 ON 2 B04180 (377041..378669) similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p SAKL0B04202g 0 378917 379666 ON 2 B04202 complement(378917..379666) similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria Sklu_2.trna10R 1 379838 379909 ON 2 tR-CCG (379838..379909) tRNA Type: Arg (R) | Anti-Codon: CCG | Cove Score: 55.51 SAKL0B04246g 1 380566 381398 ON 2 B04246 (380566..380584,381034..381398) highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W SAKL0B04268g 1 381761 383428 ON 2 B04268 (381761..383428) similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W Hypothetical ORF SAKL0B04290g 0 383568 384272 ON 2 B04290 complement(383568..384272) similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation SAKL0B04312g 0 385051 387636 ON 2 B04312 complement(385051..387636) highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex SAKL0B04334g 0 388170 388497 ON 2 B04334 complement(388170..388406,388471..388497) highly similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes SAKL0B04356g 1 389190 389789 ON 2 B04356 (389190..389789) highly similar to uniprot|Q75CV5 Ashbya gossypii ACL189C ACL189Cp and similar to YGR038W uniprot|P53224 Saccharomyces cerevisiae Sklu_2.trna11S 0 390863 390970 ON 2 tS-AGA complement(390863..390907,390934..390970) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0B04444g 0 392242 393105 ON 2 B04444 complement(392242..393105) highly similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C SAKL0B04466g 0 393589 394710 ON 2 B04466 complement(393589..394710) conserved hypothetical protein SAKL0B04488g 1 395136 396242 ON 2 B04488 (395136..396242) highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response SAKL0B04510g 1 396650 398974 ON 2 B04510 (396650..398974) similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W Hypothetical ORF SAKL0B04532g 1 399667 401544 ON 2 B04532 (399667..401544) some similarities with uniprot|P41698 Saccharomyces cerevisiae YLR353W BUD8 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern and bud at the proximal pole SAKL0B04554g 0 401845 403461 ON 2 B04554 complement(401845..403461) similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation SAKL0B04576g 1 403901 405190 ON 2 B04576 (403901..405190) similar to uniprot|O59832 Schizosaccharomyces pombe SPCC965 SPCC965.12 protein SAKL0B04598g 1 405416 406465 ON 2 B04598 (405416..406465) similar to uniprot|Q75CW0 Ashbya gossypii ACL194C ACL194Cp and weakly similar to YGR042W uniprot|P53227 Saccharomyces cerevisiae YGR042W Hypothetical ORF SAKL0B04620g 0 406622 407710 ON 2 B04620 complement(406622..407710) conserved hypothetical protein SAKL0B04642g 0 408843 409847 ON 2 B04642 complement(408843..409847) uniprot|Q875N7 Saccharomyces kluyveri TAL1 SAKL0B04664g 0 410577 411857 ON 2 B04664 complement(410577..411857) some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator SAKL0B04686g 0 412707 413378 ON 2 B04686 complement(412707..413378) similar to uniprot|P34227 Saccharomyces cerevisiae YBL064c mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress SAKL0B04708g 0 414099 415298 ON 2 B04708 complement(414099..415298) highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Acetohydroxyacid reductoisomerase mitochondrial protein involved in branched-chain amino acid biosynthesis also required for maintenance of wild- type mitochondrial DNA SAKL0B04730g 1 415911 416555 ON 2 B04730 (415911..416555) similar to uniprot|Q06485 Saccharomyces cerevisiae YLR356W Hypothetical ORF SAKL0B04752g 1 416940 418259 ON 2 B04752 (416940..418259) weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 The authentic non-tagged protein was localized to the mitochondria SAKL0B04774g 0 418498 419256 ON 2 B04774 complement(418498..419256) similar to uniprot|P53234 Saccharomyces cerevisiae YGR053C Hypothetical ORF SAKL0B04796g 1 419698 421569 ON 2 B04796 (419698..421569) similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W yeast homolog of mammalian eIF2A Sklu_2.trna12Q 0 421985 422118 ON 2 tQ-CUG complement(421985..422019,422082..422118) tRNA Type: Gln (Q) | Anti-Codon: CUG | Cove Score: 53.77 Sklu_2.trna13T 1 423023 423095 ON 2 tT-AGU (423023..423095) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 Sklu_YGOB_Anc_4.195 1 423552 425261 ON 2 Anc_4.195 (423552..424091,424095..425261) ANNOTATED BY YGOB - SAKL0B04928g 0 425881 426927 ON 2 B04928 complement(425881..426927) weakly similar to uniprot|P53686 Saccharomyces cerevisiae YPL015c HST2 similarity to HST1P and SIR2P SAKL0B04950g 1 427244 430066 ON 2 B04950 (427244..430066) similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook SAKL0B04972g 1 430349 431797 ON 2 B04972 (430349..431797) highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway SAKL0B04994g 0 431927 432640 ON 2 B04994 complement(431927..432640) similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen- regulated amino acid permease Gap1p from the Golgi to the cell surface SAKL0B05016g 1 432802 434089 ON 2 B05016 (432802..432822,432896..434089) similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting SAKL0B05038g 0 434061 435833 ON 2 B05038 complement(434061..435833) similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation SAKL0B05060g 0 436094 436327 ON 2 B05060 complement(436094..436327) conserved hypothetical protein similar to S. cerevisiae YLR361c-a SAKL0B05082g 1 436707 438896 ON 2 B05082 (436707..438896) similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p SAKL0B05104g 1 439233 442349 ON 2 B05104 (439233..442349) similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p SAKL0B05126g 1 442475 444595 ON 2 B05126 (442475..444595) similar to uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating SAKL0B05148g 1 445170 445796 ON 2 B05148 (445170..445796) similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice SAKL0B05170g 1 446357 447106 ON 2 B05170 (446357..446392,446462..447106) similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W Interacts with Top1p in 2-hybrid assay. SAKL0B05192g 1 447273 451226 ON 2 B05192 (447273..451226) similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W Hypothetical ORF SAKL0B05214g 0 452618 453559 ON 2 B05214 complement(452618..453559) weakly similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'-end of a DNA strand SAKL0B05236g 1 454145 455236 ON 2 B05236 (454145..455236) similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'- end of a DNA strand SAKL0B05258g 0 455541 455879 ON 2 B05258 complement(455541..455879) some similarities with uniprot|Q5AAI2 Candida albicans CaO19 Hypothetical protein SAKL0B05280g 0 457268 457828 ON 2 B05280 complement(457268..457828) similar to gnl|GLV|KLLA0F25080g Kluyveromyces lactis KLLA0F25080g and weakly similar to YOR297C uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 mitochondrial inner membrane translocase SAKL0B05302g 1 458611 460002 ON 2 B05302 (458611..460002) similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers SAKL0B05324g 0 460125 461354 ON 2 B05324 complement(460125..461354) similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p involved in nuclear transport SAKL0B05346g 0 461632 462084 ON 2 B05346 complement(461632..462084) highly similar to uniprot|O14467 Saccharomyces cerevisiae YOR298ca MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations SAKL0B05368g 1 462311 462748 ON 2 B05368 (462311..462748) similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9 SAKL0B05390g 1 463088 465236 ON 2 B05390 (463088..463113,463199..465236) similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W BUD7 Protein involved in bud-site selection diploid mutants display an axial-like budding pattern SAKL0B05412g 1 466158 467513 ON 2 B05412 (466158..467513) highly similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Mannosidase essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis involved in filamentous growth homologous to Dcw1p SAKL0B05434g 1 467863 468897 ON 2 B05434 (467863..468897) some similarities with uniprot|P38704 Saccharomyces cerevisiae YHR006W STP2 Transcription factor activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids activates transcription of amino acid permease genes SAKL0B05456g 1 470064 471362 ON 2 B05456 (470064..471362) similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p Sklu_2.trna14R 0 471717 471788 ON 2 tR-UCU complement(471717..471788) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.12 Sklu_YGOB_YOR302W 1 472519 472596 ON 2 YOR302W (472519..472596) ANNOTATED BY YGOB - highly similar to uniprot|P08521 Saccharomyces cerevisiae YOR302W CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA, upstream ORF SAKL0B05500g 1 472628 473851 ON 2 B05500 (472628..473851) similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor SAKL0B05522g 1 474656 478948 ON 2 B05522 (474656..478948) conserved hypothetical protein SAKL0B05544g 1 479490 482384 ON 2 B05544 (479490..482384) highly similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth SAKL0B05566g 0 482433 483950 ON 2 B05566 complement(482433..483950) similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end SAKL0B05588g 1 484376 486067 ON 2 B05588 (484376..484402,484466..486067) uniprot|Q9P903 Saccharomyces kluyveri PYD2 Dihydropyrimidinase SAKL0B05610g 0 486120 487586 ON 2 B05610 complement(486120..487586) similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p SAKL0B05632g 0 487902 488120 ON 2 B05632 complement(487902..488120) similar to uniprot|O14468 Saccharomyces cerevisiae YOR304C-A Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck SAKL0B05654g 1 488272 489006 ON 2 B05654 (488272..489006) similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF SAKL0B05676g 0 489102 490607 ON 2 B05676 complement(489102..490607) similar to uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0B05698g 0 491477 491686 ON 2 B05698 complement(491477..491686) no similarity Sklu_2.trna15S 1 492242 492349 ON 2 tS-AGA (492242..492278,492305..492349) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0B05764g 1 492867 493805 ON 2 B05764 (492867..493805) highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2 SAKL0B05786g 0 494270 495595 ON 2 B05786 complement(494270..495595) similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter Sklu_2.trna16A 1 496646 496718 ON 2 tA-AGC (496646..496718) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0B05852g 0 497081 498874 ON 2 B05852 complement(497081..498874) weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein SAKL0B05874g 0 499332 500873 ON 2 B05874 complement(499332..500873) similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA SAKL0B05896g 0 501101 501958 ON 2 B05896 complement(501101..501958) similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)-resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation Sklu_YGOB_B05918 0 502375 502943 ON 2 B05918 complement(502375..502892,502943..502943) ANNOTATED BY YGOB - SAKL0B05918g 0 502375 502815 OFF 2 B05918 complement(502375..502815) highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YOR312C RPL20B and highly similar to uniprot|P0C2I0 Saccharomyces cerevisiae YMR242C RPL20A Proteins component of the large (60S) ribosomal subunit SAKL0B05940g 1 504154 504915 ON 2 B05940 (504154..504915) similar to uniprot|Q2ZJS5 Caldicellulosiruptor saccharolyticus DSM 8903 CsacDRAFT_1700 Regulatory protein MerR SAKL0B05962g 0 505682 506584 ON 2 B05962 complement(505682..506584) similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage SAKL0B05984g 1 507408 508550 ON 2 B05984 (507408..508550) weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W Protein of unknown function found in the cytoplasm and the nucleus potential Cdc28p substrate SAKL0B06006g 0 509262 510530 ON 2 B06006 complement(509262..510530) similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1 SAKL0B06028g 1 512548 513645 ON 2 B06028 (512548..513645) similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF SAKL0B06050g 0 514120 515196 ON 2 B06050 complement(514120..515196) similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized stress- responsive protein that negatively regulates the H( )- ATPase Pma1p induced by heat shock ethanol treatment weak organic acid glucose limitation and entry into stationary phase SAKL0B06072g 0 516355 516684 ON 2 B06072 complement(516355..516684) similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF SAKL0B06094g 1 517247 519343 ON 2 B06094 (517247..519343) similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0B06116g 0 519929 521224 ON 2 B06116 complement(519929..521224) similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W Hypothetical ORF SAKL0B06138g 1 521967 523007 ON 2 B06138 (521967..523007) no similarity Sklu_2.trna17A 1 524507 524579 ON 2 tA-AGC (524507..524579) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0B06226g 1 524855 529528 ON 2 B06226 (524855..529528) similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF SAKL0B06248g 1 530697 532274 ON 2 B06248 (530697..532274) similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus SAKL0B06270g 0 532445 533074 ON 2 B06270 complement(532445..533074) similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W SAKL0B06292g 1 534860 536068 ON 2 B06292 (534860..536068) similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase SAKL0B06314g 1 537100 538872 ON 2 B06314 (537100..538872) similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress Sklu_YGOB_ABL061CA 1 539849 540022 ON 2 ABL061CA (539849..540022) ANNOTATED BY YGOB - SAKL0B06336g 1 541499 543226 ON 2 B06336 (541499..541559,542013..543226) similar to uniprot|P38248 Saccharomyces cerevisiae YBR078w and to uniprot|Q12355 Saccharomyces cerevisiae YDR055w SAKL0B06358g 0 543918 544508 ON 2 B06358 complement(543918..544508) conserved hypothetical protein SAKL0B06380g 0 545026 548034 ON 2 B06380 complement(545026..548034) similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes SAKL0B06402g 0 548471 550795 ON 2 B06402 complement(548471..550795) highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF SAKL0B06424g 0 550966 551608 ON 2 B06424 complement(550966..551304,551372..551608) weakly similar to sgd|S0002463 uniprot|Q12025 Saccharomyces cerevisiae YDR056c hypothetical protein SAKL0B06446g 1 551806 553308 ON 2 B06446 (551806..553308) weakly similar to uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 Glycoprotein of the ER membrane involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins SAKL0B06468g 0 553462 557226 ON 2 B06468 complement(553462..557226) some similarities with uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex involved in proper assembly of the complex also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Sklu_2.trna18R 1 557436 557507 ON 2 tR-UCU (557436..557507) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0B06512g 0 557855 558624 ON 2 B06512 complement(557855..558254,558581..558624) highly similar to uniprot|P15731 Saccharomyces cerevisiae YBR082C UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins interacts with E3-CaM in ubiquitinating calmodulin interacts with many SCF ubiquitin protein ligases component of the cellular stress response SAKL0B06534g 1 559594 560433 ON 2 B06534 (559594..560433) some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein SAKL0B06556g 1 563150 566323 ON 2 B06556 (563150..566323) similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Protein required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre- ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein SAKL0B06578g 1 567179 568909 ON 2 B06578 (567179..568909) some similarities with uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 transcription factor of the TEA/ATTS DNA-binding domain family regulator of Ty1 expression SAKL0B06600g 1 569406 572360 ON 2 B06600 (569406..572360) highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase involved in interconversion between different oxidation states of tetrahydrofolate (THF) provides activities of formyl-THF synthetase methenyl-THF cyclohydrolase and methylene-THF dehydrogenase SAKL0B06622g 1 572715 572927 ON 2 B06622 (572715..572927) conserved hypothetical protein SAKL0B06644g 0 573176 574134 ON 2 B06644 complement(573176..573743,574133..574134) highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A RPL19A and to uniprot|P05735 Saccharomyces cerevisiae YBL027W RPL19B Proteins component of the large (60S) ribosomal subunit SAKL0B06666g 1 574800 575141 ON 2 B06666 (574800..575141) similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C Hypothetical ORF SAKL0B06688g 0 576311 577444 ON 2 B06688 complement(576311..577444) some similarities with uniprot|P38201 Saccharomyces cerevisiae YBL029W Hypothetical ORF SAKL0B06710g 1 578075 578365 ON 2 B06710 (578075..578365) similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0B06732g 0 578508 581144 ON 2 B06732 complement(578508..581144) some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression SAKL0B06754g 1 582675 583589 ON 2 B06754 (582675..583589) uniprot|Q875Q6 Saccharomyces kluyveri PET9 SAKL0B06776g 0 584989 586122 ON 2 B06776 complement(584989..586122) similar to gnl|GLV|KLLA0E12331g Kluyveromyces lactis KLLA0E12331g and weakly similar to YBL031W uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Cytoskeletal protein of unknown function overexpression causes growth arrest SAKL0B06798g 0 586595 587557 ON 2 B06798 complement(586595..587557) similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W SAKL0B06820g 1 588770 589678 ON 2 B06820 (588770..589678) similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway SAKL0B06842g 0 590086 590343 ON 2 B06842 complement(590086..590343) similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A Hypothetical ORF SAKL0B06864g 1 591422 595669 ON 2 B06864 (591422..595669) similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta- tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles SAKL0B06886g 1 595868 597871 ON 2 B06886 (595868..597871) similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis SAKL0B06908g 0 598217 601024 ON 2 B06908 complement(598217..601024) weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C (IST2) SAKL0B06930g 1 601240 602040 ON 2 B06930 (601240..602040) similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non-specific due to the lack of the second domain which presumably determines specificity SAKL0B06952g 0 602082 604994 ON 2 B06952 complement(602082..604994) similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex SAKL0B06974g 1 605244 606314 ON 2 B06974 (605244..606314) highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon SAKL0B06996g 0 606415 607092 ON 2 B06996 complement(606415..607092) highly similar to gnl|GLV|CAGL0F04411g Candida glabrata CAGL0F04411g and highly similar to YBL038W uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit SAKL0B07018g 1 607486 608922 ON 2 B07018 (607486..608922) highly similar to uniprot|Q75B77 Ashbya gossypii ADL305C ADL305Cp and similar to YPR047W uniprot|P08425 Saccharomyces cerevisiae YPR047W MSF1 Mitochondrial phenylalanyl-tRNA synthetase alpha subunit SAKL0B07040g 1 609320 611182 ON 2 B07040 (609320..611182) similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta SAKL0B07062g 0 611326 614658 ON 2 B07062 complement(611326..614658) similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy) SAKL0B07084g 0 614698 615015 ON 2 B07084 complement(614698..615015) no similarity SAKL0B07106g 1 615231 615752 ON 2 B07106 (615231..615752) similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus SAKL0B07128g 0 615911 616757 ON 2 B07128 complement(615911..616645,616716..616757) highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair SAKL0B07150g 0 617230 617511 ON 2 B07150 complement(617230..617511) similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters SAKL0B07172g 1 617636 617959 ON 2 B07172 (617636..617959) no similarity SAKL0B07194g 0 618939 619247 ON 2 B07194 complement(618939..619247) similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins SAKL0B07216g 1 619522 621773 ON 2 B07216 (619522..619533,619599..621773) similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W Hypothetical ORF SAKL0B07238g 0 621918 623000 ON 2 B07238 complement(621918..623000) similar to gnl|GLV|KLLA0B11990g Kluyveromyces lactis KLLA0B11990g and weakly similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 Hypothetical ORF SAKL0B07282g 1 624375 625202 ON 2 B07282 (624375..625202) similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W Hypothetical ORF SAKL0B07304g 1 625541 627007 ON 2 B07304 (625541..627007) similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene SAKL0B07326g 1 627224 631477 ON 2 B07326 (627224..631477) similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting SAKL0B07348g 1 631624 634653 ON 2 B07348 (631624..634653) similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis SAKL0B07370g 1 634839 637097 ON 2 B07370 (634839..637097) similar to uniprot|P38257 Saccharomyces cerevisiae YBR098W Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA SAKL0B07392g 0 637307 638173 ON 2 B07392 complement(637307..638173) similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor cytosolic homolog of Sls1p which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum SAKL0B07414g 1 638425 640527 ON 2 B07414 (638425..640527) conserved hypothetical protein SAKL0B07436g 0 640575 642689 ON 2 B07436 complement(640575..642689) similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis SAKL0B07458g 1 642864 644393 ON 2 B07458 (642864..644393) similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 Sir4p-Interacting Factor 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal SAKL0B07480g 1 644555 645592 ON 2 B07480 (644555..645592) highly similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W Sklu_YGOB_Anc_3.346 0 645589 645966 ON 2 Anc_3.346 complement(645589..645966) ANNOTATED BY YGOB - SAKL0B07502g 1 646047 647114 ON 2 B07502 (646047..647114) similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed SAKL0B07524g 1 647326 648243 ON 2 B07524 (647326..648243) highly similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family SAKL0B07546g 0 648426 649199 ON 2 B07546 complement(648426..649199) highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis SAKL0B07568g 0 649545 650396 ON 2 B07568 complement(649545..650396) similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C SAKL0B07590g 1 651444 651902 ON 2 B07590 (651444..651902) highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism SAKL0B07612g 0 652041 652455 ON 2 B07612 complement(652041..652335,652415..652455) similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C Hypothetical ORF SAKL0B07634g 0 653801 654817 ON 2 B07634 complement(653801..654817) similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein SAKL0B07656g 1 655693 656619 ON 2 B07656 (655693..656619) similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity SAKL0B07678g 0 658061 659452 ON 2 B07678 complement(658061..659452) similar to uniprot|P00635 Saccharomyces cerevisiae YBR093C PHO5 One of three repressible acid phosphatases a glycoprotein that is transported to the cell surface by the secretory pathway induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 SAKL0B07700g 1 660896 661468 ON 2 B07700 (660896..661468) highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport SAKL0B07722g 1 661595 662536 ON 2 B07722 (661595..662536) similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0B07744g 1 663124 663681 ON 2 B07744 (663124..663681) similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2 SAKL0B07766g 0 663687 664619 ON 2 B07766 complement(663687..664619) some similarities with uniprot|P38265 Saccharomyces cerevisiae YBR107C IML3 Protein with a role in kinetochore function localizes to the outer kinetochore in a Ctf19p- dependent manner interacts with Chl4p and Ctf19p SAKL0B07788g 1 665351 667585 ON 2 B07788 (665351..667585) similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W Protein interacting with Rsv167p SAKL0B07810g 0 667715 668158 ON 2 B07810 complement(667715..668158) highly similar to uniprot|P06787 Saccharomyces cerevisiae YBR109C CMD1 master regulator of calcium mediated signalling Calmodulin SAKL0B07832g 1 668304 669746 ON 2 B07832 (668304..669746) similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum SAKL0B07854g 0 669743 671212 ON 2 B07854 complement(669743..671212) similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C SAKL0B07876g 0 671323 672207 ON 2 B07876 complement(671323..672207) highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase) SAKL0B07898g 1 672709 674049 ON 2 B07898 (672709..674049) similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 transcriptional regulator Sklu_2.trna19S 1 674362 674443 ON 2 tS-UGA (674362..674443) tRNA Type: Ser (S) | Anti-Codon: UGA | Cove Score: 84.16 SAKL0B07942g 0 674539 675315 ON 2 B07942 complement(674539..675315) similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C SAKL0B07964g 1 675352 675779 ON 2 B07964 (675352..675431,675500..675639,675700..675779) similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex SAKL0B07986g 0 675999 678641 ON 2 B07986 complement(675999..678641) highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co- repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters SAKL0B08008g 1 680730 683054 ON 2 B08008 (680730..683054) similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family SAKL0B08030g 0 683217 687392 ON 2 B08030 complement(683217..687392) highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase SAKL0B08052g 1 688482 690212 ON 2 B08052 (688482..690212) highly similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator SAKL0B08074g 0 690426 690914 ON 2 B08074 complement(690426..690914) highly similar to gnl|GLV|KLLA0B09174g Kluyveromyces lactis KLLA0B09174g and similar to YPR073C uniprot|P40347 Saccharomyces cerevisiae LTP1 phosphatase SAKL0B08096g 0 691264 693306 ON 2 B08096 complement(691264..693306) highly similar to uniprot|P23254 Saccharomyces cerevisiae TKL1 and to YBR117C uniprot|P33315 Saccharomyces cerevisiae TKL2 Transketolase SAKL0B08118g 0 693563 694834 ON 2 B08118 complement(693563..694834) weakly similar to uniprot|Q6B149 Saccharomyces cerevisiae YPR075C OPY2 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone SAKL0B08140g 1 697090 697848 ON 2 B08140 (697090..697848) conserved hypothetical protein SAKL0B08162g 1 698035 698484 ON 2 B08162 (698035..698484) no similarity SAKL0B08184g 1 698686 699807 ON 2 B08184 (698686..699807) uniprot|Q9P8S5 Saccharomyces kluyveri Alcohol dehydrogenase isozyme 3 Sklu_2.trna20E 0 700479 700550 ON 2 tE-UUC complement(700479..700550) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0B08250g 0 703194 705224 ON 2 B08250 complement(703194..705224) conserved hypothetical protein SAKL0B08272g 1 705876 706925 ON 2 B08272 (705876..706925) similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W YPRO79W MRL1 Membrane protein SAKL0B08294g 1 707757 709133 ON 2 B08294 (707757..709133) highly similar to uniprot|P02994 Saccharomyces cerevisiae YPR080W TEF1 and highly similar to uniprot|P02994 Saccharomyces cerevisiae YBR118W TEF2 Translational elongation factor EF-1 alpha; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes SAKL0B08316g 1 709603 710460 ON 2 B08316 (709603..710460) similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing SAKL0B08338g 0 710623 711096 ON 2 B08338 complement(710623..711096) similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA SAKL0B08360g 0 711383 713368 ON 2 B08360 complement(711383..713368) highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase SAKL0B08382g 0 713833 714261 ON 2 B08382 complement(713833..714261) highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri- snRNP SAKL0B08404g 0 714581 715099 ON 2 B08404 complement(714581..715099) similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit SAKL0B08426g 0 715318 717228 ON 2 B08426 complement(715318..717228) similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C, subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC) SAKL0B08448g 0 717440 718675 ON 2 B08448 complement(717440..718675) similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity SAKL0B08470g 0 719802 721319 ON 2 B08470 complement(719802..721319) highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Probable regulator of glucose influx into the cell & into glycolytic pathway indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex SAKL0B08492g 1 722818 724383 ON 2 B08492 (722818..724383) similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial Distribution and Morphology SAKL0B08514g 0 724610 726151 ON 2 B08514 complement(724610..726151) highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Vacuolar H ATPase regulatory subunit SAKL0B08536g 0 726368 727387 ON 2 B08536 complement(726368..727387) weakly similar to uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p Vps15p and Vps30p) required for organization of a pre- autophagosomal structure ATG14 transcription is activated by Gln3p during nitrogen starvation SAKL0B08558g 1 728897 730438 ON 2 B08558 (728897..730438) similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Hypothetical ORF SAKL0B08580g 0 730494 731834 ON 2 B08580 complement(730494..731834) similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C Protein required for cell viability SAKL0B08602g 0 732182 733168 ON 2 B08602 complement(732182..733168) similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone SAKL0B08624g 0 733369 734733 ON 2 B08624 complement(733369..734733) similar to uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud also required for cortical ER inheritance SAKL0B08646g 0 734944 736512 ON 2 B08646 complement(734944..736512) highly similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) contains the signal sequence-binding activity of SRP interacts with the SRP RNA and mediates binding of SRP to signal receptor contains GTPase domain SAKL0B08668g 1 736750 738681 ON 2 B08668 (736750..738681) similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly SAKL0B08690g 0 738862 739470 ON 2 B08690 complement(738862..739470) conserved hypothetical protein SAKL0B08712g 1 741051 743216 ON 2 B08712 (741051..743216) conserved hypothetical protein SAKL0B08734g 0 743379 745055 ON 2 B08734 complement(743379..745055) similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease SAKL0B08756g 1 745738 748239 ON 2 B08756 (745738..748239) similar to uniprot|Q86ZS6 Saccharomyces cerevisiae YPR089W Hypothetical ORF SAKL0B08778g 0 749128 751581 ON 2 B08778 complement(749128..751581) similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization SAKL0B08800g 1 751743 752243 ON 2 B08800 (751743..752243) highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins SAKL0B08822g 1 752590 759720 ON 2 B08822 (752590..759720) similar to uniprot|Q02580 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination, regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol (PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis SAKL0B08844g 0 759923 762553 ON 2 B08844 complement(759923..762553) similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF SAKL0B08932g 1 764315 765229 ON 2 B08932 (764315..765229) some similarities with uniprot|P53249 Saccharomyces cerevisiae YGR079W Hypothetical ORF SAKL0B08954g 1 765742 766695 ON 2 B08954 (765742..766695) similar to uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p) SAKL0B08976g 0 766719 767687 ON 2 B08976 complement(766719..767687) weakly similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain SAKL0B08998g 1 767883 768209 ON 2 B08998 (767883..768209) highly similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein SAKL0B09020g 0 768293 771298 ON 2 B09020 complement(768293..771298) some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3 Sklu_2.trna21V 0 771460 771533 ON 2 tV-AAC complement(771460..771533) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0B09064g 1 771705 774779 ON 2 B09064 (771705..774779) similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein SAKL0B09086g 0 774838 775419 ON 2 B09086 complement(774838..775419) similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C SAKL0B09108g 1 776090 776680 ON 2 B09108 (776090..776680) highly similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane SAKL0B09130g 0 776925 777486 ON 2 B09130 complement(776925..777363,777443..777486) similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF SAKL0B09152g 1 777695 778123 ON 2 B09152 (777695..778123) highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit SAKL0B09174g 0 778243 780078 ON 2 B09174 complement(778243..780078) highly similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression SAKL0B09196g 0 780749 781693 ON 2 B09196 complement(780749..781693) similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit SAKL0B09218g 1 782333 782947 ON 2 B09218 (782333..782947) similar to uniprot|Q06091 Saccharomyces cerevisiae YPR101W SNT309 Component of a protein complex associated with the splicing factor Prp19p essential for mRNA splicing SAKL0B09240g 0 783030 783554 ON 2 B09240 complement(783030..783554) highly similar to uniprot|P06380 Saccharomyces cerevisiae RPL11A and to uniprot|P06380 Saccharomyces cerevisiae YGR085C RPL11B component of the large (60S) ribosomal subunit SAKL0B09262g 1 784068 784931 ON 2 B09262 (784068..784931) highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit SAKL0B09284g 0 785056 787965 ON 2 B09284 complement(785056..787965) similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C SAKL0B09306g 0 788332 790824 ON 2 B09306 complement(788332..790824) similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex SAKL0B09328g 0 791441 792385 ON 2 B09328 complement(791441..792385) highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p SAKL0B09350g 1 793524 794798 ON 2 B09350 (793524..794798) weakly similar to uniprot|Q06098 Saccharomyces cerevisiae YPR106W ISR1 Predicted protein kinase overexpression causes sensitivity to staurosporine which is a potent inhibitor of protein kinase C SAKL0B09372g 0 795539 796171 ON 2 B09372 complement(795539..796171) highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor contains five zinc fingers required for pre-mRNA 3'-end processing and polyadenylation SAKL0B09394g 0 796461 797054 ON 2 B09394 complement(796461..797054) weakly similar to uniprot|P18411 Saccharomyces cerevisiae YAL008w FUN14 SAKL0B09416g 0 798328 800396 ON 2 B09416 complement(798328..800310,800373..800396) similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A) SAKL0B09460g 0 801018 801941 ON 2 B09460 complement(801018..801941) similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation SAKL0B09482g 1 802167 803552 ON 2 B09482 (802167..803552) similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance SAKL0B09504g 0 803571 805544 ON 2 B09504 complement(803571..805544) some similarities with uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for formation of nuclear- associated array of smooth endoplasmic reticulum known as karmellae SAKL0B09526g 1 805816 809115 ON 2 B09526 (805816..809115) similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein interacts with Rhc18p and Nse1p to form a large complex S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair SAKL0B09548g 1 809247 810911 ON 2 B09548 (809247..810911) similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene SAKL0B09570g 1 811112 811816 ON 2 B09570 (811112..811816) similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF SAKL0B09592g 0 812099 813265 ON 2 B09592 complement(812099..813265) similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER SAKL0B09614g 0 813507 814685 ON 2 B09614 complement(813507..814685) highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine SAKL0B09636g 0 815306 815626 ON 2 B09636 complement(815306..815626) highly similar to uniprot|P05319 Saccharomyces cerevisiae YOL039W RPP2A Ribosomal protein P2 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm SAKL0B09658g 1 816322 816750 ON 2 B09658 (816322..816750) highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C SAKL0B09680g 0 816974 818814 ON 2 B09680 complement(816974..818721,818784..818814) some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation SAKL0B09702g 1 819107 820528 ON 2 B09702 (819107..820528) similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C SAKL0B09724g 1 820719 821492 ON 2 B09724 (820719..821492) similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8 SAKL0B09746g 0 821862 822569 ON 2 B09746 complement(821862..822569) conserved hypothetical protein SAKL0B09768g 0 823496 824602 ON 2 B09768 complement(823496..824602) similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W SAKL0B09790g 1 824865 826043 ON 2 B09790 (824865..826043) similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase SAKL0B09812g 0 826250 828100 ON 2 B09812 complement(826250..828100) highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A SAKL0B09834g 0 828368 829396 ON 2 B09834 complement(828368..829396) some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol overexpression results in impaired peroxisome assembly SAKL0B09856g 0 830531 834355 ON 2 B09856 complement(830531..834355) similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status SAKL0B09878g 1 834821 835801 ON 2 B09878 (834821..835045,835109..835801) similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C, member GLC.2489 SAKL0B09900g 1 836551 837347 ON 2 B09900 (836551..836565,836634..837347) some similarities with uniprot|Q08219 Saccharomyces cerevisiae YOL048c or uniprot|P31379 Saccharomyces cerevisiae YAL018c SAKL0B09922g 1 837904 838855 ON 2 B09922 (837904..838071,838151..838855) weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF SAKL0B09944g 0 838880 840334 ON 2 B09944 complement(838880..840334) similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP- dependent synthesis of glutathione (GSH) from gamma- glutamylcysteine and glycine induced by oxidative stress and heat shock SAKL0B09966g 0 841275 844508 ON 2 B09966 complement(841275..844508) some similarities with uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Component of the Mediator complex interacts with RNA polymerase II and the general transcription factors to form the RNA polymerase II holoenzyme affects transcription by acting as target of activators and repressors SAKL0B09988g 0 846312 849350 ON 2 B09988 complement(846312..849350) similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p SAKL0B10010g 1 850405 851124 ON 2 B10010 (850405..851124) similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1 SAKL0B10032g 1 853065 855260 ON 2 B10032 (853065..855260) similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening SAKL0B10054g 1 855782 857089 ON 2 B10054 (855782..857089) similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes SAKL0B10076g 1 857323 859557 ON 2 B10076 (857323..859557) similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase SAKL0B10098g 0 859752 862046 ON 2 B10098 complement(859752..862046) similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C Hypothetical ORF SAKL0B10120g 0 863126 864682 ON 2 B10120 complement(863126..864682) weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression SAKL0B10142g 1 866682 871100 ON 2 B10142 (866682..871100) similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p- GTP SAKL0B10164g 1 871360 872256 ON 2 B10164 (871360..872256) some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus SAKL0B10186g 1 872881 876813 ON 2 B10186 (872881..876813) highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2 )-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA SAKL0B10208g 0 876905 878431 ON 2 B10208 complement(876905..878431) highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis SAKL0B10230g 0 878502 879473 ON 2 B10230 complement(878502..879253,879314..879402,879463..879473) similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W Hypothetical ORF SAKL0B10252g 0 879859 881256 ON 2 B10252 complement(879859..881256) some similarities with uniprot|P39734 Saccharomyces cerevisiae YAL028W FRT2 Tail-anchored endoplasmic reticulum membrane protein interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p) promotes growth in conditions of high Na alkaline pH or cell wall stress potential Cdc28p substrate SAKL0B10274g 1 881660 886324 ON 2 B10274 (881660..886324) uniprot|Q875Q8 Saccharomyces kluyveri MYO2 Myosin- 2 SAKL0B10296g 0 886750 887192 ON 2 B10296 complement(886750..886998,887112..887192) similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog SAKL0B10318g 0 888665 890509 ON 2 B10318 complement(888665..890509) similar to gnl|GLV|KLLA0F02596g Kluyveromyces lactis KLLA0F02596g and weakly similar to YOR329C uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants SAKL0B10340g 1 890646 891386 ON 2 B10340 (890646..891386) no similarity SAKL0B10362g 0 891438 895172 ON 2 B10362 complement(891438..895172) similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase SAKL0B10384g 1 895586 896278 ON 2 B10384 (895586..896278) similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa) SAKL0B10406g 1 896644 897981 ON 2 B10406 (896644..897981) similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2 ) channel required for maintenance of intramitochondrial Mg(2 ) concentrations at the correct level to support splicing of group II introns SAKL0B10428g 1 898305 900812 ON 2 B10428 (898305..900812) similar to uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate SAKL0B10450g 1 900996 902408 ON 2 B10450 (900996..902408) similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p SAKL0B10472g 0 902444 902938 ON 2 B10472 complement(902444..902938) similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0B10494g 0 903186 906056 ON 2 B10494 complement(903186..906056) highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog SAKL0B10516g 1 906415 910392 ON 2 B10516 (906415..910392) similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects SAKL0B10538g 1 910662 912767 ON 2 B10538 (910662..912767) similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer- mediated Activation Ty1 enhancer activator and to YLR098C uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc- finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain DNA-binding transcriptional activator or CHA1 SAKL0B10560g 1 913395 914483 ON 2 B10560 (913395..914483) similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF SAKL0B10582g 0 914784 915269 ON 2 B10582 complement(914784..915269) highly similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C SAKL0B10604g 0 915483 916343 ON 2 B10604 complement(915483..916343) similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly SAKL0B10626g 0 916731 917609 ON 2 B10626 complement(916731..917609) highly similar to gnl|GLV|KLLA0F02321g Kluyveromyces lactis KLLA0F02321g and similar to YOR340C uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43 SAKL0B10648g 0 917905 920103 ON 2 B10648 complement(917905..920103) conserved hypothetical protein SAKL0B10670g 1 921556 921756 ON 2 B10670 (921556..921756) no similarity Sklu_2.trna22E 1 924744 924815 ON 2 tE-UUC (924744..924815) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0B10714g 0 925250 925441 ON 2 B10714 complement(925250..925441) conserved hypothetical protein SAKL0B10736g 1 925889 930841 ON 2 B10736 (925889..930841) highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I SAKL0B10758g 0 931458 934418 ON 2 B10758 complement(931458..934418) similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2 SAKL0B10780g 1 934647 935756 ON 2 B10780 (934647..935756) highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins SAKL0B10802g 0 936119 937030 ON 2 B10802 complement(936119..937030) similar to gnl|GLV|KLLA0F23309g Kluyveromyces lactis KLLA0F23309g and weakly similar to YOR342C uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF Sklu_2.trna23M 1 938606 938678 ON 2 tM-CAU (938606..938678) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 SAKL0B10868g 0 939579 940409 ON 2 B10868 complement(939579..940409) weakly similar to uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix-loop- helix/leucine-zipper protein family SAKL0B10890g 1 941532 941795 ON 2 B10890 (941532..941795) no similarity SAKL0B10912g 1 943757 946984 ON 2 B10912 (943757..946984) similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA SAKL0B10934g 0 947188 948693 ON 2 B10934 complement(947188..948693) uniprot|Q875S4 Saccharomyces kluyveri PYK1 Pyruvate kinase SAKL0B10956g 0 949900 951618 ON 2 B10956 complement(949900..951618) similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline- specific permease SAKL0B10978g 1 953463 954785 ON 2 B10978 (953463..954785) conserved hypothetical protein SAKL0B11000g 1 956508 959645 ON 2 B11000 (956508..959645) similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta- tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl SAKL0B11022g 0 959638 961596 ON 2 B11022 complement(959638..961596) weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C SAKL0B11044g 0 962142 963767 ON 2 B11044 complement(962142..962940,963019..963086,963150..963767) similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase functions in meiotic checkpoint phosphorylates Red1p interacts with Hop1p required for meiotic recombination and normal spore viability SAKL0B11066g 1 963978 964865 ON 2 B11066 (963978..964865) similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF SAKL0B11088g 0 964961 967735 ON 2 B11088 complement(964961..967735) similar to gnl|GLV|KLLA0C13145g Kluyveromyces lactis KLLA0C13145g and some similarites with YOR353C uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability SAKL0B11110g 1 967972 968919 ON 2 B11110 (967972..968031,968104..968919) similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS) SAKL0B11132g 0 969140 971167 ON 2 B11132 complement(969140..971167) similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids SAKL0B11154g 0 971780 974473 ON 2 B11154 complement(971780..974473) similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0B11176g 1 974922 976823 ON 2 B11176 (974922..976823) similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain-containing protein required for cytokinesis SAKL0B11198g 0 977330 977902 ON 2 B11198 complement(977330..977902) similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A SAKL0B11220g 1 978268 979733 ON 2 B11220 (978268..978297,978363..979733) similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein SAKL0B11242g 0 979835 981283 ON 2 B11242 complement(979835..981283) highly similar to gnl|GLV|KLLA0F27049g Kluyveromyces lactis KLLA0F27049g and similar to YMR034C uniprot|Q05131 Saccharomyces cerevisiae Hypothetical ORF SAKL0B11264g 1 981605 982141 ON 2 B11264 (981605..982141) highly similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase SAKL0B11286g 0 982336 984222 ON 2 B11286 complement(982336..984222) some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25 SAKL0B11308g 0 984543 986369 ON 2 B11308 complement(984543..986369) similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring SAKL0B11330g 0 987814 989313 ON 2 B11330 complement(987814..989313) similar to uniprot|P33749 Saccharomyces cerevisiae YKL062W MSN4 Transcriptional activator related to Msn2p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression SAKL0B11352g 0 989401 989601 ON 2 B11352 complement(989401..989601) no similarity SAKL0B11374g 1 989864 990457 ON 2 B11374 (989864..990457) similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C Hypothetical ORF SAKL0B11396g 0 990465 991205 ON 2 B11396 complement(990465..991205) similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2- Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation SAKL0B11418g 0 991446 994235 ON 2 B11418 complement(991446..994235) similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W SAKL0B11440g 0 994656 995390 ON 2 B11440 complement(994656..995390) similar to uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator SAKL0B11462g 1 995743 996762 ON 2 B11462 (995743..996762) similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF SAKL0B11484g 0 996880 997500 ON 2 B11484 complement(996880..997500) similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein Sklu_2.trna24L 0 997679 997801 ON 2 tL-CAA complement(997679..997722,997764..997801) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 51.95 SAKL0B11583g1 1 998260 999582 ON 2 B11583 (998260..999582) Retrotransposon Gag gene co-transcribed with Pol SAKL0B11583g2 1 998260 1003528 ON 2 B11583 (998260..999561,999563..1003528) Retrotransposon Gag and Pol genes SAKL0B11638g 1 1004619 1005077 ON 2 B11638 (1004619..1005077) highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis Sklu_2.trna25F 1 1005998 1006090 ON 2 tF-GAA (1005998..1006034,1006055..1006090) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.14 SAKL0B11704g 1 1006290 1006898 ON 2 B11704 (1006290..1006898) similar to uniprot|Q75DC9 Ashbya gossypii ABR098C ABR098Cp and some similarites with YMR043W uniprot|P11746 Saccharomyces cerevisiae YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes SAKL0B11726g 1 1007438 1008706 ON 2 B11726 (1007438..1008706) weakly similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing contains a PWWP motif SAKL0B11748g 0 1008937 1010250 ON 2 B11748 complement(1008937..1010250) no similarity SAKL0B11770g 0 1011358 1015011 ON 2 B11770 complement(1011358..1015011) weakly similar to uniprot|Q02629 Saccharomyces cerevisiae YKL068W NUP100 Subunit of the nuclear pore complex (NPC) Sklu_YGOB_Anc_2.611 0 1015982 1016197 ON 2 Anc_2.611 complement(1015982..1016197) ANNOTATED BY YGOB - SAKL0B11792g 1 1016864 1018012 ON 2 B11792 (1016864..1018012) some similarities with uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis SAKL0B11814g 0 1018048 1020162 ON 2 B11814 complement(1018048..1020162) conserved hypothetical protein SAKL0B11836g 0 1020766 1023195 ON 2 B11836 complement(1020766..1023195) similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs homologous to mammalian Bop1 Sklu_2.trna26V 1 1023413 1023486 ON 2 tV-AAC (1023413..1023486) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0B11880g 0 1023561 1024094 ON 2 B11880 complement(1023561..1024094) highly similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Hypothetical ORF Sklu_2.trna27W 0 1024818 1024921 ON 2 tW-CCA complement(1024818..1024853,1024886..1024921) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 64.70 SAKL0B11924g 1 1025058 1025675 ON 2 B11924 (1025058..1025675) similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far7p Far8p Far9p Far10p and Far11p SAKL0B11946g 0 1025700 1028240 ON 2 B11946 complement(1025700..1028240) weakly similar to and weakly similar to YMR053C uniprot|P46679 Saccharomyces cerevisiae YMR053C STB2 Protein that binds Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p SAKL0B11968g 1 1028267 1030961 ON 2 B11968 (1028267..1028291,1028368..1030961) highly similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Stv1p and Vph1p) Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole SAKL0B11990g 0 1031509 1034223 ON 2 B11990 complement(1031509..1034223) similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen involved in polypeptide translocation and folding member of the Hsp70 family localizes to the lumen of the ER regulated by the unfolded protein response pathway SAKL0B12012g 1 1034446 1035996 ON 2 B12012 (1034446..1035996) similar to uniprot|Q759Z3 Ashbya gossypii ADR130W ADR130Wp and some similarities with YKL074C uniprot|P36084 Saccharomyces cerevisiae SAKL0B12034g 0 1036108 1037028 ON 2 B12034 complement(1036108..1037028) similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator forms GTPase- activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies blocks cell cycle progression before anaphase in response to spindle and kinetochore damage SAKL0B12056g 1 1037786 1039663 ON 2 B12056 (1037786..1039663) similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high- affinity iron uptake and involved in mediating resistance to copper ion toxicity belongs to class of integral membrane multicopper oxidases SAKL0B12078g 1 1040952 1042406 ON 2 B12078 (1040952..1042406) some similarities with uniprot|P36083 Saccharomyces cerevisiae YKL075C Hypothetical ORF SAKL0B12100g 0 1042547 1043716 ON 2 B12100 complement(1042547..1043716) similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W SAKL0B12122g 1 1043881 1044234 ON 2 B12122 (1043881..1044234) similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p SAKL0B12144g 0 1044255 1045220 ON 2 B12144 complement(1044255..1045220) similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex required for the sorting of some proteins to the outer membrane after import by the TOM complex SAKL0B12166g 1 1045306 1047285 ON 2 B12166 (1045306..1047285) similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends bridges interaction between Rna15p and Hrp1p in the CF I complex SAKL0B12188g 0 1047724 1050000 ON 2 B12188 complement(1047724..1050000) highly similar to uniprot|Q75DV8 Ashbya gossypii ABL085W ABL085Wp and similar to YJR143C uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D-mannose:protein O-D- mannosyltransferase SAKL0B12210g 1 1050090 1051007 ON 2 B12210 (1050090..1051007) similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance component of the mitochondrial nucleoid required for the repair of oxidative mtDNA damage SAKL0B12232g 0 1051164 1052201 ON 2 B12232 complement(1051164..1052201) conserved hypothetical protein Sklu_2.trna28V 1 1053122 1053194 ON 2 tV-CAC (1053122..1053194) tRNA Type: Val (V) | Anti-Codon: CAC | Cove Score: 75.70 SAKL0B12298g 1 1053731 1055500 ON 2 B12298 (1053731..1055500) similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Hypothetical ORF SAKL0B12320g 0 1055740 1056864 ON 2 B12320 complement(1055740..1056511,1056851..1056864) highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B SAKL0B12342g 1 1057850 1060240 ON 2 B12342 (1057850..1060240) similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides SAKL0B12364g 1 1060853 1063021 ON 2 B12364 (1060853..1063021) highly similar to uniprot|Q75BF3 Ashbya gossypii ADL389W ADL389Wp and similar to YHR205W uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts SAKL0B12386g 1 1063970 1064323 ON 2 B12386 (1063970..1064323) no similarity SAKL0B12408g 1 1065161 1066558 ON 2 B12408 (1065161..1066558) similar to uniprot|Q75BF2 Ashbya gossypii ADL388W ADL388Wp and weakly similar to YHR206W uniprot|P38889 Saccharomyces cerevisiae SAKL0B12430g 0 1066751 1068217 ON 2 B12430 complement(1066751..1068217) similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5 SAKL0B12452g 1 1068425 1069141 ON 2 B12452 (1068425..1069141) similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria SAKL0B12474g 0 1069235 1069873 ON 2 B12474 complement(1069235..1069873) similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis SAKL0B12496g 1 1070225 1071418 ON 2 B12496 (1070225..1071418) highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase SAKL0B12518g 1 1072142 1073932 ON 2 B12518 (1072142..1073932) conserved hypothetical protein SAKL0B12540g 0 1075772 1077490 ON 2 B12540 complement(1075772..1077490) highly similar to uniprot|P39003 Saccharomyces cerevisiae YDR343C HXT6 High-affinity glucose transporter of the major facilitator superfamily nearly identical to Hxt7p expressed at high basal levels relative to other HXTs repression of expression by high glucose requires SNF3 SAKL0B12562g 0 1082192 1083619 ON 2 B12562 complement(1082192..1083619) similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4- aminobutyrate aminotransferase) involved in the 4- aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization SAKL0B12584g 1 1086099 1087826 ON 2 B12584 (1086099..1087826) similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine SAKL0B12606g 1 1089114 1089581 ON 2 B12606 (1089114..1089581) similar to uniprot|Q06592 Saccharomyces cerevisiae YPR193C HPA2 Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p SAKL0B12628g 0 1091243 1092856 ON 2 B12628 complement(1091243..1092856) similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter member of the major facilitator superfamily involved in efflux of fluconazole diazaborine benomyl methotrexate and other drugs SAKL0B12650g 0 1093366 1093581 ON 2 B12650 complement(1093366..1093581) no similarity SAKL0B12672g 0 1096894 1097751 ON 2 B12672 complement(1096894..1097751) weakly similar to uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism sole identified regulatory target is SSU1 overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1 contains five zinc fingers SAKL0B12694g 0 1099946 1100341 ON 2 B12694 complement(1099946..1100341) some similarities with uniprot|Q13LV9 Burkholderia xenovorans Bxeno_B1962 Bxe_B1024 Putative proline racemase SAKL0B12716g 1 1101141 1103039 ON 2 B12716 (1101141..1103039) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF SAKL0B12738g 1 1104405 1105910 ON 2 B12738 (1104405..1105910) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0B12760g 1 1106443 1106631 ON 2 B12760 (1106443..1106631) no similarity SAKL0B12804g 0 1110670 1111230 ON 2 B12804 complement(1110670..1111230) no similarity SAKL0B12826g 0 1113599 1115059 ON 2 B12826 complement(1113599..1115059) similar to uniprot|Q75A58 Ashbya gossypii ADR061C ADR061Cp and weakly similar to YBR158W uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability SAKL0C00110g 0 1950 2522 ON 3 C00110 complement(1950..2522) no similarity SAKL0C00154g 0 4145 5860 ON 3 C00154 complement(4145..5860) highly similar to uniprot|P53387 Kluyveromyces lactis KHT2 Hexose transporter 2 SAKL0C00176g 1 7427 9184 ON 3 C00176 (7427..9184) highly similar to uniprot|P40884 Saccharomyces cerevisiae YJL216C Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance SAKL0C00198g 1 11539 12207 ON 3 C00198 (11539..12207) no similarity SAKL0C00220g 1 12778 13677 ON 3 C00220 (12778..13677) similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF SAKL0C00242g 1 14453 16954 ON 3 C00242 (14453..16954) weakly similar to uniprot|P39961 Saccharomyces cerevisiae YER184C Hypothetical ORF SAKL0C00264g 0 17429 18508 ON 3 C00264 complement(17429..18508) highly similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance SAKL0C00308g 0 22119 23831 ON 3 C00308 complement(22119..23831) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions SAKL0C00330g 0 24778 28587 ON 3 C00330 complement(24778..28587) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation SAKL0C00352g 0 32166 33848 ON 3 C00352 complement(32166..33848) similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression SAKL0C00374g 1 34149 34460 ON 3 C00374 (34149..34460) no similarity SAKL0C00396g 0 35526 36728 ON 3 C00396 complement(35526..36728) highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism SAKL0C00418g 0 37529 38623 ON 3 C00418 complement(37529..38623) similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase SAKL0C00440g 1 39662 41050 ON 3 C00440 (39662..41050) weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance SAKL0C00462g 0 41257 44790 ON 3 C00462 complement(41257..44790) some similarities with uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint SAKL0C00484g 0 45059 46078 ON 3 C00484 complement(45059..46078) highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit SAKL0C00506g 1 46439 46756 ON 3 C00506 (46439..46756) weakly similar to uniprot|Q2V2Q1 Saccharomyces cerevisiae YCL058W-A SAKL0C00528g 0 47403 47735 ON 3 C00528 complement(47403..47735) similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A SAKL0C00550g 1 48410 50608 ON 3 C00550 (48410..50608) highly similar to gnl|GLV|KLLA0C00572g Kluyveromyces lactis KLLA0C00572g and similar to YCL057W uniprot|P25375 Saccharomyces cerevisiae YCL057W PRD1 Zinc metalloendopeptidase found in the cytoplasm and intermembrane space of mitochondria SAKL0C00572g 0 51031 52047 ON 3 C00572 complement(51031..52047) conserved hypothetical protein SAKL0C00594g 1 53526 54629 ON 3 C00594 (53526..54629) conserved hypothetical protein SAKL0C00616g 1 55269 58190 ON 3 C00616 (55269..58190) weakly similar to uniprot|P37020 Saccharomyces cerevisiae YJR040w Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates SAKL0C00638g 0 58341 60176 ON 3 C00638 complement(58341..60176) no similarity SAKL0C00660g 1 60914 61903 ON 3 C00660 (60914..61903) similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KAR4 Transcription factor required for induction of KAR3 and CIK1 during mating also required during meiosis exists in two forms a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone SAKL0C00682g 0 62173 63789 ON 3 C00682 complement(62173..63789) conserved hypothetical protein SAKL0C00704g 1 64319 66868 ON 3 C00704 (64319..66868) highly similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants SAKL0C00726g 0 67127 68524 ON 3 C00726 complement(67127..68524) similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X SAKL0C00748g 1 69102 70511 ON 3 C00748 (69102..70511) some similarities with uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes SAKL0C00770g 0 71357 71740 ON 3 C00770 complement(71357..71740) similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C SAKL0C00792g 0 72288 73247 ON 3 C00792 complement(72288..73247) similar to uniprot|P22108 Saccharomyces cerevisiae YDR530C or similar to uniprot|P16550 Saccharomyces cerevisiae YCL050C SAKL0C00814g 1 73822 74886 ON 3 C00814 (73822..74886) similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W Pantothenate kinase (ATP:D-pantothenate 4'- phosphotransferase EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA. SAKL0C00836g 0 75136 76188 ON 3 C00836 complement(75136..76188) weakly similar to uniprot|Q6Q537 Saccharomyces cerevisiae YDR532C Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles forms a complex with Spc105p SAKL0C00858g 0 77103 78467 ON 3 C00858 complement(77103..78467) similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W Sklu_YGOB_SNA2 0 78849 79085 ON 3 SNA2 complement(78849..79085) ANNOTATED BY YGOB - SAKL0C00880g 0 79636 80418 ON 3 C00880 complement(79636..80418) similar to uniprot|P32460 Saccharomyces cerevisiae YIR030C DCG1 Protein of unknown function expression is sensitive to nitrogen catabolite repression and regulated by Dal80p contains transmembrane domain SAKL0C00902g 0 80576 80869 ON 3 C00902 complement(80576..80869) no similarity Sklu_YGOB_YDR524C-B 1 81284 81481 ON 3 YDR524C-B (81284..81481) ANNOTATED BY YGOB - SAKL0C00924g 1 81919 84351 ON 3 C00924 (81919..84351) some similarities with uniprot|Q04412 Saccharomyces cerevisiae YDR524C AGE1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways SAKL0C00946g 1 84995 86689 ON 3 C00946 (84995..86689) similar to uniprot|Q751V1 Ashbya gossypii AFR724C AFR724Cp and some similarites with YDR523C uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis SAKL0C00968g 1 87107 88549 ON 3 C00968 (87107..88549) similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta-glucan layer of the spore wall and similar to uniprot|P08459 Saccharomyces cerevisiae YDR522C SAKL0C00990g 1 89385 91976 ON 3 C00990 (89385..91976) similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF SAKL0C01012g 0 92130 92909 ON 3 C01012 complement(92130..92909) similar to uniprot|P25576 Saccharomyces cerevisiae YCL047C Hypothetical ORF SAKL0C01034g 0 93401 93826 ON 3 C01034 complement(93401..93826) similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking SAKL0C01056g 0 94133 96340 ON 3 C01056 complement(94133..96340) similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C SAKL0C01078g 0 96790 97989 ON 3 C01078 complement(96790..97989) similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C SAKL0C01100g 0 98462 100054 ON 3 C01100 complement(98462..100054) similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI1 Protein disulfide isomerase of the endoplasmic reticulum lumen and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518w EUG1 Sklu_3.trna1N 0 100592 100665 ON 3 tN-GUU complement(100592..100665) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0C01144g 0 100873 102015 ON 3 C01144 complement(100873..102015) similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks SAKL0C01166g 1 102520 104016 ON 3 C01166 (102520..104016) highly similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non- fermentable carbon sources SAKL0C01188g 1 104624 106948 ON 3 C01188 (104624..106948) similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W SAKL0C01210g 0 107136 108656 ON 3 C01210 complement(107136..108656) similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole SAKL0C01232g 1 110269 112110 ON 3 C01232 (110269..112110) similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids SAKL0C01254g 0 112824 114299 ON 3 C01254 complement(112824..114299) weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 cytoplasmic RNA-binding protein that associates with translating ribosomes and weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515w RNA binding protein that associates with polysomes SAKL0C01276g 1 114863 116185 ON 3 C01276 (114863..116185) similar to uniprot|P25370 Saccharomyces cerevisiae YDR514C Hypothetical ORF and similar to YCL036w SAKL0C01298g 1 116567 117934 ON 3 C01298 (116567..117934) no similarity SAKL0C01320g 0 118401 118898 ON 3 C01320 complement(118401..118898) similar to uniprot|P25373 Saccharomyces cerevisiae YCL035C GRX1 Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair protects cells from oxidative damage and similar to uniprot|P17695 Saccharomyces cerevisiae YDR513w cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase SAKL0C01342g 1 119161 120195 ON 3 C01342 (119161..120195) similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization SAKL0C01364g 0 120315 120788 ON 3 C01364 complement(120315..120788) similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF SAKL0C01386g 1 121406 121666 ON 3 C01386 (121406..121666) some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C EMI1 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation SAKL0C01408g 1 121950 122909 ON 3 C01408 (121950..122909) similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction SAKL0C01430g 0 123125 124006 ON 3 C01430 complement(123125..124006) similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing SAKL0C01452g 0 124309 124710 ON 3 C01452 complement(124309..124710) similar to uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes SAKL0C01474g 0 125472 127919 ON 3 C01474 complement(125472..127919) highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C SAKL0C01496g 0 128271 129794 ON 3 C01496 complement(128271..129794) similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170 SAKL0C01518g 1 130285 131412 ON 3 C01518 (130285..131412) some similarities with uniprot|Q8TFP8 Saccharomyces cerevisiae YCL028W RNQ1 [PIN(+)] prion an infectious protein conformation that is generally an ordered protein aggregate SAKL0C01540g 0 131588 133156 ON 3 C01540 complement(131588..133156) some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins SAKL0C01562g 1 133507 133980 ON 3 C01562 (133507..133980) no similarity SAKL0C01584g 0 134381 135402 ON 3 C01584 complement(134381..134997,135393..135402) no similarity SAKL0C01606g 1 136175 138025 ON 3 C01606 (136175..138025) similar to gnl|GLV|KLLA0C01540g Kluyveromyces lactis KLLA0C01540g and weakly similar to YCL027W uniprot|P11710 Saccharomyces cerevisiae YCL027W FUS1 Membrane protein localized to the shmoo tip required for cell fusion expression regulated by mating pheromone proposed to coordinate signaling fusion and polarization events required for fusion potential Cdc28p substrate SAKL0C01628g 0 138111 138929 ON 3 C01628 complement(138111..138929) highly similar to uniprot|Q96VH4 Saccharomyces cerevisiae YCL026C-B Hypothetical ORF SAKL0C01650g 0 139480 141321 ON 3 C01650 complement(139480..141321) similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids SAKL0C01672g 0 141689 142306 ON 3 C01672 complement(141689..142306) no similarity SAKL0C01694g 1 142861 143154 ON 3 C01694 (142861..143154) highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W SAKL0C01716g 1 143880 147527 ON 3 C01716 (143880..147527) similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C SAKL0C01738g 0 147860 149149 ON 3 C01738 complement(147860..149149) conserved hypothetical protein SAKL0C01760g 0 149641 154065 ON 3 C01760 complement(149641..154065) weakly similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF Sklu_3.trna2L 1 154454 154576 ON 3 tL-CAA (154454..154491,154533..154576) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.74 SAKL0C01804g 1 155529 157496 ON 3 C01804 (155529..157496) weakly similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition SAKL0C01826g 0 158426 159109 ON 3 C01826 complement(158426..159109) similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation SAKL0C01848g 1 159782 160939 ON 3 C01848 (159782..160939) weakly similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2 )-independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA SAKL0C01870g 1 161890 163044 ON 3 C01870 (161890..163044) highly similar to uniprot|P10659 Saccharomyces cerevisiae YLR180W SAM1 S-adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p) SAKL0C01892g 0 163233 164657 ON 3 C01892 complement(163233..164657) some similarities with uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled-coil domains mutants show class E vacuolar-protein sorting defects SAKL0C01914g 1 164842 167127 ON 3 C01914 (164842..167127) similar to uniprot|P09959 Saccharomyces cerevisiae YLR182W SWI6 Transcription cofactor forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition involved in meiotic gene expression localization regulated by phosphorylation potential Cdc28p substrate SAKL0C01936g 0 167330 169138 ON 3 C01936 complement(167330..169138) some similarities with uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF SAKL0C01958g 1 169755 170601 ON 3 C01958 (169755..169761,170342..170601) highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit Sklu_YGOB_LCD1 0 171213 172928 ON 3 LCD1 complement(171213..172928) ANNOTATED BY YGOB - SAKL0C02002g 1 173704 174462 ON 3 C02002 (173704..174462) highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs SAKL0C02024g 0 174858 177554 ON 3 C02024 complement(174858..177554) similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p SAKL0C02046g 0 179321 180475 ON 3 C02046 complement(179321..180475) conserved hypothetical protein SAKL0C02068g 0 180898 181296 ON 3 C02068 complement(180898..181296) no similarity SAKL0C02090g 0 183513 184754 ON 3 C02090 complement(183513..184754) conserved hypothetical protein SAKL0C02112g 0 185610 187370 ON 3 C02112 complement(185610..187370) highly similar to uniprot|Q08295 Saccharomyces cerevisiae YOL157C Hypothetical ORF SAKL0C02134g 1 188874 190589 ON 3 C02134 (188874..190589) highly similar to uniprot|P40886 Saccharomyces cerevisiae YJL214W HXT8 SAKL0C02156g 0 190829 191137 ON 3 C02156 complement(190829..191137) some similarities with uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease SAKL0C02178g 0 191542 193239 ON 3 C02178 complement(191542..193239) weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane SAKL0C02200g 1 194464 196458 ON 3 C02200 (194464..196458) similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p SAKL0C02222g 1 197312 200773 ON 3 C02222 (197312..200773) weakly similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate And to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily- conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation SAKL0C02244g 1 201281 203419 ON 3 C02244 (201281..203419) similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress SAKL0C02266g 1 203861 205309 ON 3 C02266 (203861..205309) similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway SAKL0C02288g 0 205701 209663 ON 3 C02288 complement(205701..209663) similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy SAKL0C02310g 0 210191 211564 ON 3 C02310 complement(210191..211564) similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain SAKL0C02332g 1 211864 212660 ON 3 C02332 (211864..212068,212179..212660) weakly similar to uniprot|P40014 Saccharomyces cerevisiae YER018C SPC25 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p- Nuf2p-Spc24p-Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering SAKL0C02354g 1 212822 213895 ON 3 C02354 (212822..213895) similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability SAKL0C02376g 1 214343 216010 ON 3 C02376 (214343..216010) similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W SAKL0C02398g 1 216509 216901 ON 3 C02398 (216509..216901) similar to uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF SAKL0C02420g 0 217079 218128 ON 3 C02420 complement(217079..218128) similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase SAKL0C02442g 1 218718 223301 ON 3 C02442 (218718..223301) some similarities with uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation SAKL0C02464g 1 223721 226042 ON 3 C02464 (223721..226042) similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF SAKL0C02486g 0 226824 228353 ON 3 C02486 complement(226824..228353) conserved hypothetical protein SAKL0C02508g 0 229683 231044 ON 3 C02508 complement(229683..231044) conserved hypothetical protein SAKL0C02530g 0 232075 232344 ON 3 C02530 complement(232075..232344) no similarity SAKL0C02552g 1 232852 236553 ON 3 C02552 (232852..236553) similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I SAKL0C02574g 0 236779 238200 ON 3 C02574 complement(236779..238200) similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters SAKL0C02596g 0 238404 240608 ON 3 C02596 complement(238404..240608) similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport SAKL0C02618g 0 240920 246886 ON 3 C02618 complement(240920..246886) some similarities with uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1 SAKL0C02640g 0 247651 249297 ON 3 C02640 complement(247651..249297) highly similar to uniprot|Q875R1 Saccharomyces kluyveri CAN1 and similar to YEL063C uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance SAKL0C02662g 0 249789 251435 ON 3 C02662 complement(249789..251435) uniprot|Q875R1 Saccharomyces kluyveri CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance SAKL0C02684g 0 251988 253754 ON 3 C02684 complement(251988..253754) similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance SAKL0C02706g 0 253808 254287 ON 3 C02706 complement(253808..254287) no similarity SAKL0C02728g 1 255022 256710 ON 3 C02728 (255022..256710) similar to uniprot|P32487 Saccharomyces cerevisiae YNL268w LYP1 lysine-specific high-affinity permease SAKL0C02750g 1 257629 260706 ON 3 C02750 (257629..260706) similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5- biphosphate may control cytokineses through the actin cytoskeleton SAKL0C02772g 1 261339 262493 ON 3 C02772 (261339..262493) similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p SAKL0C02794g 0 262684 263753 ON 3 C02794 complement(262684..263559,263730..263753) similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large-scale protein- protein interaction data SAKL0C02816g 0 264072 267428 ON 3 C02816 complement(264072..267428) similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C SAKL0C02838g 1 267853 268965 ON 3 C02838 (267853..268965) similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol SAKL0C02860g 0 269190 272909 ON 3 C02860 complement(269190..272909) similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF SAKL0C02882g 0 273511 274938 ON 3 C02882 complement(273511..274938) similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition SAKL0C02904g 0 275106 275951 ON 3 C02904 complement(275106..275951) weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C SAKL0C02926g 0 276274 277215 ON 3 C02926 complement(276274..277215) similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C SAKL0C02948g 1 277748 284584 ON 3 C02948 (277748..284584) similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair SAKL0C02970g 1 285647 287425 ON 3 C02970 (285647..287425) some similarities with uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. SAKL0C02992g 1 288290 290383 ON 3 C02992 (288290..290383) similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels SAKL0C03014g 1 290985 292439 ON 3 C03014 (290985..292439) similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing SAKL0C03036g 1 292782 294125 ON 3 C03036 (292782..294125) weakly similar to uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication SAKL0C03058g 0 294159 294656 ON 3 C03058 complement(294159..294656) similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability SAKL0C03080g 0 294978 295199 ON 3 C03080 complement(294978..295199) highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p which is a multicopper oxidase required for high-affinity iron uptake SAKL0C03102g 0 295593 296825 ON 3 C03102 complement(295593..296825) conserved hypothetical protein SAKL0C03124g 0 296848 297357 ON 3 C03124 complement(296848..297357) conserved hypothetical protein SAKL0C03146g 0 297918 300170 ON 3 C03146 complement(297918..300170) weakly similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)- localized peripheral membrane protein required for Golgi- to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat Sklu_YGOB_snR71 0 300509 300541 ON 3 snR71 complement(300509..300541) ANNOTATED BY YGOB - location of BlastN HSP using Scer query SAKL0C03190g 0 300939 304898 ON 3 C03190 complement(300939..304898) similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C-terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF SAKL0C03212g 0 305187 306434 ON 3 C03212 complement(305187..306434) similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase SAKL0C03234g 0 306710 307732 ON 3 C03234 complement(306710..307732) conserved hypothetical protein SAKL0C03256g 0 307960 309408 ON 3 C03256 complement(307960..309408) similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane SAKL0C03278g 1 309787 312474 ON 3 C03278 (309787..312474) similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities SAKL0C03300g 0 312773 313369 ON 3 C03300 complement(312773..313369) highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C SAKL0C03322g 0 313909 315030 ON 3 C03322 complement(313909..315030) some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF SAKL0C03344g 1 315639 317087 ON 3 C03344 (315639..317087) weakly similar to uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component SAKL0C03366g 0 317486 318301 ON 3 C03366 complement(317486..318301) similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit SAKL0C03388g 0 318605 320548 ON 3 C03388 complement(318605..320548) some similarities with uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs SAKL0C03410g 1 321385 325407 ON 3 C03410 (321385..325407) similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining SAKL0C03432g 0 325502 327145 ON 3 C03432 complement(325502..327145) similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein of unknown function SAKL0C03454g 0 327573 328811 ON 3 C03454 complement(327573..328811) highly similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49 SAKL0C03476g 1 329030 329527 ON 3 C03476 (329030..329527) similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain SAKL0C03498g 0 329645 331636 ON 3 C03498 complement(329645..331636) similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF SAKL0C03520g 1 332124 334517 ON 3 C03520 (332124..334517) similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability SAKL0C03542g 1 334898 335686 ON 3 C03542 (334898..335686) similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75 SAKL0C03564g 0 335837 336520 ON 3 C03564 complement(335837..336520) similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C SAKL0C03586g 1 337347 341771 ON 3 C03586 (337347..341771) weakly similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF SAKL0C03608g 1 341968 342516 ON 3 C03608 (341968..342516) conserved hypothetical protein SAKL0C03630g 0 343351 343677 ON 3 C03630 complement(343351..343677) highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1 SAKL0C03652g 1 344282 347464 ON 3 C03652 (344282..347464) weakly similar to uniprot|P33338 Saccharomyces cerevisiae YNL243W SLA2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization adaptor protein that links actin to clathrin and endocytosis present in the actin cortical patch of the emerging bud tip dimer in vivo SAKL0C03674g 0 347672 348232 ON 3 C03674 complement(347672..348232) some similarities with uniprot|P01366 Saccharomyces cerevisiae YCR097W Silenced copy of a1 at HMR SAKL0C03696g 1 348999 350219 ON 3 C03696 (348999..350219) some similarities with uniprot|Q6B184 Saccharomyces cerevisiae YCR096C Silenced copy of a2 at HMR SAKL0C03718g 1 350498 351364 ON 3 C03718 (350498..351364) similar to uniprot|P87332 Saccharomyces cerevisiae YLR348C DIC1 Mitochondrial dicarboxylate carrier integral membrane protein catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane transports cytoplasmic dicarboxylates into the mitochondrial matrix Sklu_YGOB_gneas1 0 352893 354335 ON 3 gneas1 complement(352893..354335) ANNOTATED BY YGOB - possible frameshift into ORF downstream SAKL0C03762g 1 355675 356688 ON 3 C03762 (355675..356688) similar to uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin peroxisomal membrane protein with a C-terminal zinc-binding RING domain forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import SAKL0C03784g 1 357131 359080 ON 3 C03784 (357131..359080) similar to uniprot|P07252 Saccharomyces cerevisiae YJL209W CBP1 Protein required for COB mRNA stability or 5' processing required for translation of COB mRNAs SAKL0C03806g 0 359499 360503 ON 3 C03806 complement(359499..360503) similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease has RNAse and DNA endo- and exonucleolytic activities has a role in mitochondrial recombination SAKL0C03828g 0 360861 367190 ON 3 C03828 complement(360861..367190) similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF Sklu_3.trna3G 0 367391 367461 ON 3 tG-GCC complement(367391..367461) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0C03872g 1 369348 370121 ON 3 C03872 (369348..370121) no similarity SAKL0C03894g 1 371240 373303 ON 3 C03894 (371240..373303) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) SAKL0C03916g 1 375906 376733 ON 3 C03916 (375906..376733) no similarity SAKL0C03938g 0 377431 379773 ON 3 C03938 complement(377431..379773) weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins and to YJL206C uniprot|P39529 Saccharomyces cerevisiae YJL206C SAKL0C03960g 1 380387 383488 ON 3 C03960 (380387..383488) conserved hypothetical protein Sklu_YGOB_NCE101 0 383580 383816 ON 3 NCE101 complement(383580..383816) ANNOTATED BY YGOB - SAKL0C03982g 1 384195 385241 ON 3 C03982 (384195..385241) conserved hypothetical protein SAKL0C04004g 0 385333 387726 ON 3 C04004 complement(385333..387726) similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1 SAKL0C04026g 1 387854 389320 ON 3 C04026 (387854..389320) weakly similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex SAKL0C04048g 1 390021 392249 ON 3 C04048 (390021..392249) some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments Sklu_3.trna4K 1 392525 392614 ON 3 tK-UUU (392525..392561,392579..392614) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 67.82 SAKL0C04092g 1 392774 394576 ON 3 C04092 (392774..394576) similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p Sklu_YGOB_BUD5 1 395220 399808 ON 3 BUD5 (395220..398233,398235..398277,398279..399808) ANNOTATED BY YGOB - 2 frameshifts corrected by reverting to original 2003 Cliften et al S. kluyveri BUD5 data. SAKL0C04136g 1 400535 401416 ON 3 C04136 (400535..401416) similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Hypothetical ORF SAKL0C04158g 0 401695 404226 ON 3 C04158 complement(401695..404226) conserved hypothetical protein SAKL0C04180g 0 404913 407279 ON 3 C04180 complement(404913..407279) highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF Sklu_3.trna5T 0 407716 407788 ON 3 tT-AGU complement(407716..407788) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 SAKL0C04224g 1 409345 412014 ON 3 C04224 (409345..412014) uniprot|Q875Q5 Saccharomyces kluyveri PHO87 SAKL0C04246g 1 412865 416758 ON 3 C04246 (412865..416758) similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins SAKL0C04268g 0 416891 417925 ON 3 C04268 complement(416891..417925) similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase SAKL0C04290g 1 418324 419472 ON 3 C04290 (418324..419472) similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing SAKL0C04312g 0 419735 420781 ON 3 C04312 complement(419735..420781) similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3-beta- glucan synthase vacuolar ATPase and the secretory pathway SAKL0C04334g 0 421044 425423 ON 3 C04334 complement(421044..425423) some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1 Sklu_YGOB_AFR622W 0 426127 427978 ON 3 AFR622W complement(426127..427273,427275..427978) ANNOTATED BY YGOB - SAKL0C04378g 1 428601 430142 ON 3 C04378 (428601..430142) similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association homologous to S. pombe Cdc18p SAKL0C04400g 1 430411 431628 ON 3 C04400 (430411..431628) similar to uniprot|P39542 Saccharomyces cerevisiae YJL193W Hypothetical ORF SAKL0C04422g 0 431806 438456 ON 3 C04422 complement(431806..438456) similar to uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1 SAKL0C04444g 0 438826 439500 ON 3 C04444 complement(438826..439500) similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7 SAKL0C04466g 1 440462 441239 ON 3 C04466 (440462..440471,440833..441239) highly similar to uniprot|P06367 Saccharomyces cerevisiae YCR031C RPS14A ribosomal protein 59 (rp59) of the small (40S) ribosomal subunit SAKL0C04488g 0 441633 442025 ON 3 C04488 complement(441633..442025) highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and highly similar to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit SAKL0C04510g 1 442727 443403 ON 3 C04510 (442727..442732,443254..443403) similar to uniprot|P04650 Saccharomyces cerevisiae YJL189W RPL39 Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1 SAKL0C04576g 0 444365 446611 ON 3 C04576 complement(444365..446611) similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate SAKL0C04598g 1 447448 449283 ON 3 C04598 (447448..449283) similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment SAKL0C04620g 1 449901 452414 ON 3 C04620 (449901..452414) similar to uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein with a potential role in actin cytoskeletal organization overexpression suppresses a pfy1 (profilin) null mutation SAKL0C04642g 0 452552 453463 ON 3 C04642 complement(452552..453463) conserved hypothetical protein SAKL0C04664g 1 453723 454263 ON 3 C04664 (453723..453961,454032..454263) similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance Single- stranded zinc finger DNA-binding protein SAKL0C04686g 1 454628 455026 ON 3 C04686 (454628..455026) similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Protein of unknown function proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides also proposed to be involved in responding to osmotic stress SAKL0C04708g 1 455246 456799 ON 3 C04708 (455246..456799) similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph SAKL0C04730g 1 457122 458402 ON 3 C04730 (457122..458402) similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p Mnn9p Mnn10p and Hoc1p and mediates elongation of the polysaccharide mannan backbone has homology to Mnn10p SAKL0C04752g 1 458773 461394 ON 3 C04752 (458773..461394) weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C Hypothetical ORF SAKL0C04774g 0 461644 462603 ON 3 C04774 complement(461644..462603) similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase SAKL0C04796g 1 462757 463257 ON 3 C04796 (462757..463257) similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin SAKL0C04818g 0 463491 464591 ON 3 C04818 complement(463491..464591) similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type II membrane protein that binds phosphatidylinositol 3-phosphate required for the cytoplasm-to-vacuole targeting (Cvt) pathway SAKL0C04840g 1 465054 465930 ON 3 C04840 (465054..465362,465685..465930) highly similar to uniprot|P46990 Saccharomyces cerevisiae YJL177W RPL17B Protein and uniprot|P05740 Saccharomyces cerevisiae YKL180W RPL17A Protein component of the large (60S) ribosomal subunit; copurifies with the components of the outer kinetochore DASH complex SAKL0C04862g 0 466119 468167 ON 3 C04862 complement(466119..468167) similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C SAKL0C04884g 0 468461 471157 ON 3 C04884 complement(468461..471157) some similarities with uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 transcription factor SAKL0C04906g 1 472043 472903 ON 3 C04906 (472043..472903) similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects SAKL0C04928g 0 473107 473592 ON 3 C04928 complement(473107..473592) similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination SAKL0C04950g 1 474025 475749 ON 3 C04950 (474025..475749) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions SAKL0C04972g 0 475936 477405 ON 3 C04972 complement(475936..477405) similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Cell surface a factor receptor transcribed in alpha cells and required for mating by alpha cells couples to MAP kinase cascade to mediate pheromone response ligand bound receptors undergo endocytosis and recycling to the plasma membrane SAKL0C04994g 0 477974 479179 ON 3 C04994 complement(477974..479179) similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C Hypothetical ORF SAKL0C05016g 0 479484 480698 ON 3 C05016 complement(479484..480698) similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C Hypothetical ORF SAKL0C05038g 0 481147 481890 ON 3 C05038 complement(481147..481890) some similarities with uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha- factor Sklu_YGOB_Anc_1.170 0 482157 483413 OFF 3 Anc_1.170 complement(482157..483413) ANNOTATED BY YGOB - Sklu_YGOB_Anc_1.170b 0 482157 484243 ON 3 Anc_1.170b complement(482157..483668,483671..484243) ANNOTATED BY YGOB - Sklu_YGOB_Anc_1.171 0 484546 485757 ON 3 Anc_1.171 complement(484546..485757) ANNOTATED BY YGOB - SAKL0C05104g 1 487143 488606 ON 3 C05104 (487143..488606) some similarities with uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter transports zinc from storage in the vacuole to the cytoplasm when needed transcription is induced under conditions of zinc deficiency SAKL0C05126g 0 488745 490451 ON 3 C05126 complement(488745..490451) similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine putative polyamine transporter in the Golgi or post-Golgi vesicles SAKL0C05170g 1 494064 495317 ON 3 C05170 (494064..495317) similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly localizes to the nucleolus SAKL0C05192g 1 495987 497042 ON 3 C05192 (495987..497042) highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167W ERG20 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis SAKL0C05214g 1 497580 497864 ON 3 C05214 (497580..497864) highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Ubiquinol cytochrome-c reductase subunit 8 SAKL0C05236g 1 498347 501385 ON 3 C05236 (498347..501385) similar to gnl|GLV|KLLA0A06776g Kluyveromyces lactis KLLA0A06776g and weakly similar to YKL171W uniprot|P36003 Saccharomyces cerevisiae YKL171W Hypothetical ORF SAKL0C05258g 1 501564 502019 ON 3 C05258 (501564..502019) highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels SAKL0C05280g 0 502205 504490 ON 3 C05280 complement(502205..504490) similar to uniprot|Q757X8 Ashbya gossypii AEL118C AEL118Cp and some similarites with YJL165C uniprot|P38970 Saccharomyces cerevisiae YJL165C HAL5 Putative protein kinase overexpression increases sodium and lithium tolerance whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake suggesting a role in regulation of Trk1p and/or Trk2p transporters SAKL0C05302g 0 504841 507006 ON 3 C05302 complement(504841..507006) conserved hypothetical protein SAKL0C05324g 0 507260 509374 ON 3 C05324 complement(507260..509374) conserved hypothetical protein SAKL0C05346g 0 509817 510212 ON 3 C05346 complement(509817..510212) similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation SAKL0C05368g 0 510576 511832 ON 3 C05368 complement(510576..511832) similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit SAKL0C05390g 0 513161 513484 ON 3 C05390 complement(513161..513484) no similarity SAKL0C05412g 0 514226 516064 ON 3 C05412 complement(514226..516064) similar to gnl|GLV|KLLA0B07227g Kluyveromyces lactis KLLA0B07227g and weakly similar to YJL163C uniprot|P46996 Saccharomyces cerevisiae YJL163C Hypothetical ORF SAKL0C05434g 0 516536 519643 ON 3 C05434 complement(516536..519643) similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes SAKL0C05456g 0 519700 521451 ON 3 C05456 complement(519700..521451) similar to uniprot|Q757X4 Ashbya gossypii AEL112C AEL112Cp and some similarites with YJL162C uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain Sklu_3.trna6N 0 521629 521702 ON 3 tN-GUU complement(521629..521702) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 Sklu_3.trna7E 0 522136 522207 ON 3 tE-CUC complement(522136..522207) tRNA Type: Glu (E) | Anti-Codon: CUC | Cove Score: 61.61 SAKL0C05522g 1 522482 523048 ON 3 C05522 (522482..523048) weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161W FMP33 The authentic non-tagged protein was localized to the mitochondria SAKL0C05544g 0 523441 524436 ON 3 C05544 complement(523441..524436) similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats SAKL0C05566g 1 525939 527096 ON 3 C05566 (525939..527096) similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats SAKL0C05588g 1 527748 529781 ON 3 C05588 (527748..529781) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF Sklu_3.trna8C 0 529846 529917 ON 3 tC-GCA complement(529846..529917) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 SAKL0C05632g 0 530250 531902 ON 3 C05632 complement(530250..531902) similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W SAKL0C05654g 0 532258 536787 ON 3 C05654 complement(532258..536787) highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid- inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity SAKL0C05676g 0 537764 538360 ON 3 C05676 complement(537764..538360) similar to uniprot|Q757W5 Ashbya gossypii AEL103W AEL103Wp and some similarites with YKL164C uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats SAKL0C05698g 0 539308 542775 ON 3 C05698 complement(539308..542775) weakly similar to uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate SAKL0C05720g 0 543485 545731 ON 3 C05720 complement(543485..545731) similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes SAKL0C05742g 0 546510 547808 ON 3 C05742 complement(546510..547808) highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism SAKL0C05764g 0 548288 551125 ON 3 C05764 complement(548288..551125) similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component SAKL0C05786g 1 551987 553045 ON 3 C05786 (551987..553045) similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress SAKL0C05808g 1 553571 554122 ON 3 C05808 (553571..554122) similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C FMP18 The authentic non-tagged protein was localized to the mitochondria SAKL0C05830g 0 554282 554692 ON 3 C05830 complement(554282..554692) similar to uniprot|P14359 Saccharomyces cerevisiae YJL151C SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein- vacuolar targeting SAKL0C05852g 0 554962 555510 ON 3 C05852 complement(554962..555510) no similarity Sklu_3.trna9L 0 555585 555804 ON 3 tL-CAG complement(555585..555633,555768..555804) tRNA Type: Leu (L) | Anti-Codon: CAG | Cove Score: 38.04 SAKL0C05896g 1 556798 558618 ON 3 C05896 (556798..558618) similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W SAKL0C05918g 0 558911 561538 ON 3 C05918 complement(558911..561538) similar to uniprot|Q75BN0 Ashbya gossypii ACR241C ACR241Cp and weakly similar to YKR064W uniprot|P36023 Saccharomyces cerevisiae YKR064W Hypothetical ORF SAKL0C05940g 1 562096 563619 ON 3 C05940 (562096..563619) weakly similar to uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability SAKL0C06006g 1 564936 565577 ON 3 C06006 (564936..565577) similar to gnl|GLV|KLLA0A05973g Kluyveromyces lactis KLLA0A05973g and weakly similar to YJL148W uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5 SAKL0C06028g 0 565820 566701 ON 3 C06028 complement(565820..566701) similar to uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit involved in RNA polymerase II transcription initiation SAKL0C06050g 0 567562 568782 ON 3 C06050 complement(567562..568782) weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C Hypothetical ORF SAKL0C06072g 1 569086 570369 ON 3 C06072 (569086..570369) weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis appears to act indirectly to promote Ime2p-mediated late meiotic functions found in growing cells and degraded during sporulation SAKL0C06094g 1 570643 571512 ON 3 C06094 (570643..571512) similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 putative phosphatidylinositol transfer protein SAKL0C06116g 0 571813 572370 ON 3 C06116 complement(571813..572370) some similarities with uniprot|P13090 Saccharomyces cerevisiae YML116W ATR1 Multidrug efflux pump of the major facilitator superfamily required for resistance to aminotriazole and 4-nitroquinoline-N-oxide SAKL0C06138g 1 572845 573150 ON 3 C06138 (572845..573150) no similarity SAKL0C06160g 0 573363 573860 ON 3 C06160 complement(573363..573860) no similarity SAKL0C06182g 0 574577 575779 ON 3 C06182 complement(574577..575779) highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase catalyzes the conversion of dethiobiotin to biotin which is the last step of the biotin biosynthesis pathway complements E. coli bioB mutant SAKL0C06204g 1 576347 576841 ON 3 C06204 (576347..576841) no similarity SAKL0C06226g 1 577183 577653 ON 3 C06226 (577183..577653) highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Mitochondrial inner membrane protein involved in protein import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins SAKL0C06248g 0 577990 580185 ON 3 C06248 complement(577990..580185) similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal SAKL0C06270g 1 580778 581383 ON 3 C06270 (580778..581383) highly similar to uniprot|Q75BM1 Ashbya gossypii ACR250W ACR250Wp and similar to YJL140W uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32 forms two subunit dissociable complex with Rpb7p dispensable under some environmental conditions involved in export of mRNA to cytoplasm under stress conditions SAKL0C06292g 0 581679 583106 ON 3 C06292 complement(581679..583106) similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family SAKL0C06314g 0 583198 584013 ON 3 C06314 complement(583198..584013) similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data SAKL0C06336g 0 584406 585599 ON 3 C06336 complement(584406..585599) highly similar to uniprot|P10081 Saccharomyces cerevisiae YKR059W TIF1 translation initiation factor eIF4A and highly similar to uniprot|P10081 Saccharomyces cerevisiae YJL138C TIF2 SAKL0C06358g 0 586041 587543 ON 3 C06358 complement(586041..587543) some similarities with uniprot|P47011 Saccharomyces cerevisiae YJL137C SAKL0C06380g 0 588128 588903 ON 3 C06380 complement(588128..588367,588880..588903) highly similar to uniprot|P05760 Saccharomyces cerevisiae YJL136C SAKL0C06402g 0 589497 591305 ON 3 C06402 complement(589497..591305) similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation previously thought to be an endo-exonuclease SAKL0C06424g 0 591532 592395 ON 3 C06424 complement(591532..592395) similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely to be involved in the establishment of cell polarity SAKL0C06446g 1 592873 605394 ON 3 C06446 (592873..605394) similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein microtubule motor protein required for anaphase spindle elongation involved in spindle assembly chromosome movement and spindle orientation during cell division targeted to microtubule tips by Pac1p SAKL0C06468g 1 605621 606895 ON 3 C06468 (605621..606895) similar to uniprot|P47013 Saccharomyces cerevisiae YJL134W LCB3 Long-chain base-1-phosphate phosphatase regulates ceramide and long-chain base phosphates levels involved in incorporation of exogenous long chain bases in sphingolipids SAKL0C06490g 0 607087 607335 ON 3 C06490 complement(607087..607335) some similarities with uniprot|Q3E7A3 Saccharomyces cerevisiae YJL133C-A SAKL0C06512g 1 608274 609182 ON 3 C06512 (608274..609182) similar to uniprot|P23500 Saccharomyces cerevisiae YKR052C Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low- iron conditions; may transport other cations in addition to iron SAKL0C06534g 0 609575 610822 ON 3 C06534 complement(609575..610822) similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Hypothetical ORF SAKL0C06556g 1 611209 613509 ON 3 C06556 (611209..613509) similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Hypothetical ORF SAKL0C06578g 0 613598 614779 ON 3 C06578 complement(613598..614779) similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C Hypothetical ORF SAKL0C06600g 0 615551 622213 ON 3 C06600 complement(615551..622213) highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase and gnl|GLV|KLLA0E15444g Kluyveromyces lactis SAKL0C06622g 0 623647 627603 ON 3 C06622 complement(623647..627603) similar to uniprot|P12685 Saccharomyces cerevisiae YJL129C TRK1 Component of the Trk1p-Trk2p potassium transport system 180 kDa high affinity potassium transporter SAKL0C06666g 0 628448 630367 ON 3 C06666 complement(628448..630367) similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway activated under severe osmotic stress SAKL0C06688g 0 630413 631105 ON 3 C06688 complement(630413..631105) no similarity SAKL0C06710g 0 631217 631372 ON 3 C06710 complement(631217..631372) highly similar to uniprot|Q3E828 Saccharomyces cerevisiae YJL127C-B Identified by homology to Ashbya gossypii SAKL0C06732g 1 631641 633776 ON 3 C06732 (631641..633776) conserved hypothetical protein SAKL0C06754g 0 634164 636110 ON 3 C06754 complement(634164..636110) similar to uniprot|Q755M9 Ashbya gossypii AFL215C AFL215Cp and some similarites with YJL127C uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase required for transcriptional regulation at core promoters functions at or near the TATA box SAKL0C06776g 1 636660 637568 ON 3 C06776 (636660..637568) similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W SAKL0C06798g 0 637636 638841 ON 3 C06798 complement(637636..638841) highly similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1- methyladenosine) methyltransferase with Gcd10p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression SAKL0C06820g 1 639751 641274 ON 3 C06820 (639751..641274) conserved hypothetical protein SAKL0C06842g 0 641777 642253 ON 3 C06842 complement(641777..642253) highly similar to uniprot|Q755M6 Ashbya gossypii AFL212C AFL212Cp and similar to YJL124C uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay SAKL0C06864g 1 642690 643181 ON 3 C06864 (642690..643181) similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 The authentic non-tagged protein was localized to the mitochondria SAKL0C06886g 0 643560 645020 ON 3 C06886 complement(643560..645020) similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C Hypothetical ORF SAKL0C06908g 1 645295 645783 ON 3 C06908 (645295..645783) similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W Hypothetical ORF SAKL0C06930g 0 645890 646600 ON 3 C06930 complement(645890..646600) highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-Phosphate 3- epimerase Sklu_3.trna10Y 0 646782 646881 ON 3 tY-GUA complement(646782..646817,646843..646881) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 71.08 SAKL0C06996g 0 649424 654061 ON 3 C06996 complement(649424..654061) similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 SAKL0C07018g 1 655130 655894 ON 3 C07018 (655130..655894) no similarity SAKL0C07040g 1 656558 657886 ON 3 C07040 (656558..657886) similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p required for the regulation of microtubule dynamics during mitosis controls bud morphogenesis involved in the transport of H2A and H2B histones to the nucleus SAKL0C07062g 1 658247 659215 ON 3 C07062 (658247..659215) similar to gnl|GLV|KLLA0E15092g Kluyveromyces lactis KLLA0E15092g and weakly similar to YKR046C uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange SAKL0C07084g 0 659941 660876 ON 3 C07084 complement(659941..660599,660684..660876) similar to uniprot|P36138 Saccharomyces cerevisiae YKR045C SAKL0C07106g 1 660909 662036 ON 3 C07106 (660909..662036) similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane transcription and localization are regulated by phosphate levels SAKL0C07128g 0 662248 663606 ON 3 C07128 complement(662248..663606) similar to uniprot|P36137 Saccharomyces cerevisiae YKR044W UIP5 Protein of unknown function SAKL0C07150g 1 663839 664651 ON 3 C07150 (663839..664651) highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Hypothetical ORF SAKL0C07172g 1 664749 665936 ON 3 C07172 (664749..665936) weakly similar to uniprot|Q05947 Saccharomyces cerevisiae YLR224W Hypothetical ORF SAKL0C07194g 0 666869 668017 ON 3 C07194 complement(666869..668017) some similarities with uniprot|P36135 Saccharomyces cerevisiae YKR042W UTH1 Youth involved in determining yeast longevity involved in cell growth SAKL0C07216g 1 669133 670368 ON 3 C07216 (669133..670368) conserved hypothetical protein SAKL0C07238g 1 670799 671887 ON 3 C07238 (670799..671887) some similarities with uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor involved in chromatin assembly after DNA replication anti- silencing protein that causes derepression of silent loci when overexpressed SAKL0C07260g 0 671976 672854 ON 3 C07260 complement(671976..672854) weakly similar to uniprot|P36134 Saccharomyces cerevisiae YKR041W Hypothetical ORF Sklu_3.trna11A 0 673015 673087 ON 3 tA-AGC complement(673015..673087) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0C07304g 1 673183 676761 ON 3 C07304 (673183..676761) some similarities with uniprot|Q7LGP7 Saccharomyces cerevisiae YOL063C HUS1 Protein of unknown function SAKL0C07348g 1 677348 679933 ON 3 C07348 (677348..679933) some similarities with uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p SAKL0C07370g 0 680403 681693 ON 3 C07370 complement(680403..681556,681672..681693) highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity SAKL0C07392g 0 682073 683158 ON 3 C07392 complement(682073..683158) some similarities with uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF SAKL0C07414g 0 683859 685307 ON 3 C07414 complement(683859..685307) similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit SAKL0C07436g 1 685905 687320 ON 3 C07436 (685905..687320) similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes SAKL0C07458g 0 687452 689395 ON 3 C07458 complement(687452..689395) some similarities with uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p SAKL0C07480g 0 690119 692374 ON 3 C07480 complement(690119..692374) similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C SAKL0C07502g 1 693395 694771 ON 3 C07502 (693395..694771) highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase key enzyme of glycerol synthesis essential for growth under osmotic stress expression regulated by high-osmolarity glycerol response pathway homolog of Gpd2p SAKL0C07524g 0 695945 697117 ON 3 C07524 complement(695945..697117) similar to uniprot|P47177 Saccharomyces cerevisiae YJR149W Hypothetical ORF SAKL0C07546g 1 698084 699340 ON 3 C07546 (698084..699340) highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate SAKL0C07568g 1 699767 701923 ON 3 C07568 (699767..701923) similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF SAKL0C07590g 1 702466 703365 ON 3 C07590 (702466..703365) similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 and to YDL021W uniprot|Q12008 Saccharomyces cerevisiae YDL021W GPM2, Homologs of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis SAKL0C07612g 0 703833 705557 ON 3 C07612 complement(703833..705557) some similarities with uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses SAKL0C07634g 0 705949 707661 ON 3 C07634 complement(705949..707661) similar to uniprot|Q6B2F0 Saccharomyces cerevisiae YOL055C THI20 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI21 and THI22 functionally redundant with Thi21p SAKL0C07656g 1 708798 709985 ON 3 C07656 (708798..709985) similar to gnl|GLV|KLLA0C04125g Kluyveromyces lactis KLLA0C04125g and weakly similar to YGL038C uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins SAKL0C07678g 0 710170 714099 ON 3 C07678 complement(710170..714099) some similarities with uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability SAKL0C07700g 0 714795 716960 ON 3 C07700 complement(714795..716960) similar to uniprot|P80235 YAR035W Saccharomyces cerevisiae YAT1 Outer carnitine acetyltransferase mitochondrial SAKL0C07722g 1 717419 720157 ON 3 C07722 (717419..720157) similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p SAKL0C07744g 1 720519 721799 ON 3 C07744 (720519..721799) similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role SAKL0C07766g 0 722109 723026 ON 3 C07766 complement(722109..723026) highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4- carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenine SAKL0C07788g 1 723553 725649 ON 3 C07788 (723553..725649) some similarities with uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0C07810g 1 725872 728964 ON 3 C07810 (725872..728964) similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg-nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression SAKL0C07832g 1 729689 731314 ON 3 C07832 (729689..731314) some similarities with uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression SAKL0C07854g 0 731508 732203 ON 3 C07854 complement(731508..732203) similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C SAKL0C07876g 1 732534 733970 ON 3 C07876 (732534..733970) similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression SAKL0C07898g 0 734082 735005 ON 3 C07898 complement(734082..735005) similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis SAKL0C07920g 0 735512 737317 ON 3 C07920 complement(735512..737317) similar to uniprot|P42833 Saccharomyces cerevisiae YNL318C SAKL0C07942g 1 738408 739845 ON 3 C07942 (738408..738444,738914..739845) similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W SAKL0C07964g 1 740340 742211 ON 3 C07964 (740340..742211) similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p SAKL0C07986g 1 742551 743696 ON 3 C07986 (742551..743696) conserved hypothetical protein SAKL0C08008g 0 743966 744514 ON 3 C08008 complement(743966..744268,744380..744514) similar to uniprot|Q12489 Saccharomyces cerevisiae YDL012C Plasma membrane protein of unknown function SAKL0C08030g 1 745420 746904 ON 3 C08030 (745420..746904) weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p SAKL0C08052g 0 747101 747643 ON 3 C08052 complement(747101..747643) similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Hypothetical ORF SAKL0C08074g 0 747926 751699 ON 3 C08074 complement(747926..751699) similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF SAKL0C08096g 1 752508 753086 ON 3 C08096 (752508..753086) highly similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co- chaperone GimC/prefoldin complex which promotes efficient protein folding SAKL0C08118g 0 753182 754039 ON 3 C08118 complement(753182..754039) similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF SAKL0C08140g 1 754583 756283 ON 3 C08140 (754583..756283) similar to uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal SAKL0C08162g 1 756652 757125 ON 3 C08162 (756652..757125) similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit SAKL0C08184g 1 757467 758219 ON 3 C08184 (757467..758219) similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome SAKL0C08206g 0 758536 758961 ON 3 C08206 complement(758536..758961) highly similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein SAKL0C08228g 1 760184 760714 ON 3 C08228 (760184..760714) no similarity SAKL0C08250g 1 760891 762999 ON 3 C08250 (760891..762999) no similarity SAKL0C08272g 1 765088 766434 ON 3 C08272 (765088..766434) no similarity SAKL0C08294g 1 767317 768018 ON 3 C08294 (767317..768018) conserved hypothetical protein SAKL0C08316g 0 768040 769125 ON 3 C08316 complement(768040..769125) no similarity SAKL0C08338g 0 769319 770800 ON 3 C08338 complement(769319..770800) weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons SAKL0C08360g 1 771051 772427 ON 3 C08360 (771051..772427) similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein-protein binding SAKL0C08382g 1 773107 774036 ON 3 C08382 (773107..774036) highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization SAKL0C08404g 1 774497 775309 ON 3 C08404 (774497..775309) similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes SAKL0C08426g 1 775904 776533 ON 3 C08426 (775904..776533) similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation SAKL0C08448g 1 777053 777340 ON 3 C08448 (777053..777340) similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit SAKL0C08470g 0 777539 778531 ON 3 C08470 complement(777539..778531) similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin SAKL0C08492g 0 778821 780068 ON 3 C08492 complement(778821..780068) similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription SAKL0C08514g 0 780655 782688 ON 3 C08514 complement(780655..782688) weakly similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate SAKL0C08536g 0 782964 784739 ON 3 C08536 complement(782964..784739) weakly similar to uniprot|Q6UZ93 Saccharomyces cerevisiae YHR176W FMO1,Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins SAKL0C08558g 1 785340 786755 ON 3 C08558 (785340..786755) similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering SAKL0C08580g 0 786827 787612 ON 3 C08580 complement(786827..787612) similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly SAKL0C08602g 0 787882 789786 ON 3 C08602 complement(787882..789786) similar to uniprot|P06700 Saccharomyces cerevisiae YDL042C SIR2 Conserved NAD dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan plays roles in silencing at HML HMR telomeres and the rDNA locus negatively regulates initiation of DNA replication SAKL0C08624g 0 790593 791159 ON 3 C08624 complement(790593..791159) similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus SAKL0C08646g 0 791710 794277 ON 3 C08646 complement(791710..794277) similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing SAKL0C08668g 0 794592 796448 ON 3 C08668 complement(794592..796448) similar to uniprot|Q12362 Saccharomyces cerevisiae and weakly similar to YDL036C uniprot|Q12069 Saccharomyces cerevisiae YDL036C Hypothetical ORF SAKL0C08690g 0 796677 797822 ON 3 C08690 complement(796677..797822) similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5-bisphosphate 5- phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins SAKL0C08712g 0 798170 801337 ON 3 C08712 complement(798170..801337) some similarities with uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G-protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis SAKL0C08734g 0 801591 802655 ON 3 C08734 complement(801591..802655) highly similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'- phosphoadenosine-5'-phosphosulfate intermediates of the sulfate assimilation pathway SAKL0C08756g 0 802996 804237 ON 3 C08756 complement(802996..804237) similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln SAKL0C08778g 1 804617 807628 ON 3 C08778 (804617..807628) similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD- box protein family SAKL0C08800g 1 807712 809517 ON 3 C08800 (807712..809517) similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly SAKL0C08822g 1 809753 811033 ON 3 C08822 (809753..811033) similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP- diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP- diaclglyerol a critical step in the synthesis of all major yeast phospholipids SAKL0C08844g 1 811712 813307 ON 3 C08844 (811712..813307) similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF SAKL0C08866g 0 813414 813932 ON 3 C08866 complement(813414..813932) no similarity SAKL0C08888g 1 814687 816726 ON 3 C08888 (814687..816726) weakly similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment SAKL0C08910g 1 817058 818203 ON 3 C08910 (817058..818203) similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis SAKL0C08932g 0 818420 819724 ON 3 C08932 complement(818420..819724) similar to uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations Sklu_3.trna12N 1 819925 819998 ON 3 tN-GUU (819925..819998) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0C08976g 0 820524 821057 ON 3 C08976 complement(820524..820699,820811..821057) similar to uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Sklu_3.trna13R 1 821271 821342 ON 3 tR-UCU (821271..821342) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0C09020g 1 821470 822540 ON 3 C09020 (821470..822540) similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF SAKL0C09042g 0 822884 823750 ON 3 C09042 complement(822884..823750) similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Sklu_3.trna14T 1 824007 824079 ON 3 tT-AGU (824007..824079) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 72.63 SAKL0C09086g 0 824735 826000 ON 3 C09086 complement(824735..826000) some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC4 SAKL0C09108g 1 826301 826963 ON 3 C09108 (826301..826963) similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0C09130g 1 829840 832176 ON 3 C09130 (829840..832176) weakly similar to uniprot|P38894 Saccharomyces cerevisiae YHR211W SAKL0C09174g 0 833618 836833 ON 3 C09174 complement(833618..836833) similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis SAKL0C09196g 1 837987 839369 ON 3 C09196 (837987..839369) no similarity SAKL0C09218g 1 839747 840691 ON 3 C09218 (839747..840691) similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc SAKL0C09240g 1 841020 841376 ON 3 C09240 (841020..841376) similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae YDR493W FMP36 SAKL0C09262g 1 841769 842455 ON 3 C09262 (841769..842455) similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase SAKL0C09284g 1 842783 843859 ON 3 C09284 (842783..843859) weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation SAKL0C09306g 0 844023 846812 ON 3 C09306 complement(844023..846812) weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein SAKL0C09328g 0 847128 849143 ON 3 C09328 complement(847128..849143) similar to Q04373 YDR496C uniprot|Q04373 Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences SAKL0C09350g 0 849691 851427 ON 3 C09350 complement(849691..851427) similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C ITR1 SAKL0C09372g 0 852233 853279 ON 3 C09372 complement(852233..853279) weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p SAKL0C09394g 1 853828 854898 ON 3 C09394 (853828..854898) weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1, Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes SAKL0C09416g 1 855222 856577 ON 3 C09416 (855222..856577) highly similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions SAKL0C09438g 0 856783 858066 ON 3 C09438 complement(856783..858066) similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae SAKL0C09460g 0 858338 858949 ON 3 C09460 complement(858338..858949) similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus SAKL0C09504g 0 865789 868998 ON 3 C09504 complement(865789..868998) similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF SAKL0C09548g 1 869380 869775 ON 3 C09548 (869380..869775) no similarity SAKL0C09570g 0 869888 870739 ON 3 C09570 complement(869888..870739) similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery SAKL0C09592g 1 871039 872907 ON 3 C09592 (871039..872907) weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8 SAKL0C09614g 0 873273 874946 ON 3 C09614 complement(873273..874946) similar to gnl|GLV|KLLA0F11077g Kluyveromyces lactis KLLA0F11077g and some similarities with YNL125C uniprot|P53918 Saccharomyces cerevisiae ESBP6 Sklu_3.trna15R 0 875344 875437 ON 3 tR-ACG complement(875344..875379,875401..875437) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 64.63 SAKL0C09658g 1 876217 876852 ON 3 C09658 (876217..876852) highly similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4- phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration SAKL0C09680g 0 876981 878399 ON 3 C09680 complement(876981..878399) highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA SAKL0C09702g 1 878556 879239 ON 3 C09702 (878556..879239) similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative) SAKL0C09724g 0 879298 880281 ON 3 C09724 complement(879298..880281) similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C SAKL0C09746g 1 880534 882699 ON 3 C09746 (880534..882699) weakly similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting SAKL0C09768g 0 882835 885000 ON 3 C09768 complement(882835..885000) similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP- dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription SAKL0C09790g 0 885402 887210 ON 3 C09790 complement(885402..887210) similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W SAKL0C09812g 0 887754 888713 ON 3 C09812 complement(887754..888713) highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon SAKL0C09834g 1 888944 889855 ON 3 C09834 (888944..889855) similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W SAKL0C09856g 1 890259 891176 ON 3 C09856 (890259..891176) similar to Q12010 YOL092W uniprot|Q12010 Saccharomyces cerevisiae Hypothetical ORF SAKL0C09878g 1 891673 894195 ON 3 C09878 (891673..894195) weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110, Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle- dependent manner SAKL0C09900g 1 894566 897460 ON 3 C09900 (894566..897460) highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process contains a Walker ATP- binding motif required for repair activity Msh2p-Msh6p binds to and hydrolyzes ATP SAKL0C09922g 1 897779 898747 ON 3 C09922 (897779..898747) similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified SAKL0C09944g 0 899127 902312 ON 3 C09944 complement(899127..902312) weakly similar to uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression SAKL0C09966g 1 902383 903516 ON 3 C09966 (902383..903516) similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus SAKL0C09988g 0 903636 904376 ON 3 C09988 complement(903636..904376) weakly similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family exhibits chaperone activity overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions undergoes oxidation by Ero1p SAKL0C10010g 1 904772 905977 ON 3 C10010 (904772..905977) conserved hypothetical protein SAKL0C10032g 1 906377 907369 ON 3 C10032 (906377..907369) conserved hypothetical protein SAKL0C10054g 1 907502 908302 ON 3 C10054 (907502..908302) similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase catalyzes the second step of the riboflavin biosynthesis pathway SAKL0C10076g 0 908528 909175 ON 3 C10076 complement(908528..909175) highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27 common to RNA polymerases I II and III contacts DNA and affects transactivation SAKL0C10098g 0 909553 912489 ON 3 C10098 complement(909553..912489) similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Hypothetical ORF SAKL0C10120g 1 912994 913326 ON 3 C10120 (912994..913326) similar to uniprot|Q3E835 Saccharomyces cerevisiae YOL086W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. SAKL0C10142g 0 913490 914338 ON 3 C10142 complement(913490..914338) similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit SAKL0C10164g 0 914732 915787 ON 3 C10164 complement(914732..915787) uniprot|Q6XQ74 Saccharomyces kluyveri ADH1 Alcohol dehydrogenase 1 SAKL0C10186g 1 916849 917847 ON 3 C10186 (916849..917847) highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases SAKL0C10208g 0 918253 919665 ON 3 C10208 complement(918253..919665) no similarity SAKL0C10230g 1 920651 923566 ON 3 C10230 (920651..923566) similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole SAKL0C10252g 1 924082 925797 ON 3 C10252 (924082..925797) conserved hypothetical protein SAKL0C10274g 1 926159 927463 ON 3 C10274 (926159..927463) highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor SAKL0C10296g 0 927939 930377 ON 3 C10296 complement(927939..930377) similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits SAKL0C10318g 1 930573 931607 ON 3 C10318 (930573..931607) similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF SAKL0C10340g 1 932285 941218 ON 3 C10340 (932285..941218) weakly similar to uniprot|P18963 Saccharomyces cerevisiae YBR140c IRA1 or uniprot|P19158 Saccharomyces cerevisiae YOL081w IRA2 SAKL0C10362g 0 941677 942663 ON 3 C10362 complement(941677..942663) similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly SAKL0C10384g 1 943002 946613 ON 3 C10384 (943002..946613) weakly similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth SAKL0C10406g 0 946709 948196 ON 3 C10406 complement(946709..948196) similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Hypothetical ORF Sklu_YGOB_Anc_3.128 1 948810 949013 ON 3 Anc_3.128 (948810..949013) ANNOTATED BY YGOB - SAKL0C10428g 0 949262 950143 ON 3 C10428 complement(949262..950143) highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein involved in the biogenesis of large ribosomal subunits depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits possesses a sigma(70)-like RNA- binding motif SAKL0C10450g 1 950474 952876 ON 3 C10450 (950474..952876) similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met involved in mitochondrial inheritance and actin assembly SAKL0C10472g 1 953238 955064 ON 3 C10472 (953238..955064) similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment SAKL0C10494g 1 955694 956386 ON 3 C10494 (955694..956386) similar to Saccharomyces cerevisiae YDL010W Hypothetical ORF or YBR014C uniprot|P38068 Saccharomyces cerevisiae YBR014C Hypothetical ORF SAKL0C10516g 1 956666 957100 ON 3 C10516 (956666..957100) similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase- Promoting Complex/Cyclosome (APC/C) which is a ubiquitin- protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition Sklu_3.trna16T 0 957192 957264 ON 3 tT-AGU complement(957192..957264) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 SAKL0C10560g 1 957963 958826 ON 3 C10560 (957963..958826) highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase) catalyzes the rapid exchange of oxygens from Pi with water highly expressed and essential for viability active-site residues show identity to those from E. coli PPase SAKL0C10582g 0 958876 959553 ON 3 C10582 complement(958876..959553) similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis in 2004 the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) SAKL0C10604g 1 960046 962115 ON 3 C10604 (960046..962115) conserved hypothetical protein SAKL0C10626g 1 962421 963389 ON 3 C10626 (962421..963389) similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified SAKL0C10648g 1 967431 968219 ON 3 C10648 (967431..968219) weakly similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity SAKL0C10670g 0 969988 970344 ON 3 C10670 complement(969988..970344) no similarity SAKL0C10692g 0 970753 971556 ON 3 C10692 complement(970753..971556) highly similar to uniprot|P61830 Saccharomyces cerevisiae YBR010W HHT1 and highly similar to uniprot|P61830 Saccharomyces cerevisiae YNL031C HHT2, histone H3 proteins SAKL0C10714g 1 971840 972151 ON 3 C10714 (971840..972151) highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity SAKL0C10736g 1 972764 975607 ON 3 C10736 (972764..975607) similar to uniprot|Q757K1 Ashbya gossypii and weakly similar to YDR006C, uniprot|P40317 Saccharomyces cerevisiae YDR006C (SOK1), SAKL0C10758g 1 976369 978489 ON 3 C10758 (976369..978489) some similarities with uniprot|P38213 Saccharomyces cerevisiae YBR007C DSF2 SAKL0C10780g 1 978873 980159 ON 3 C10780 (978873..980159) similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment targets the initiation factor TFIIIB SAKL0C10802g 0 980437 981819 ON 3 C10802 complement(980437..981819) similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad55p SAKL0C10824g 0 982077 983564 ON 3 C10824 complement(982077..983564) highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma- aminobutyrate (GABA) as a nitrogen source part of the 4- aminobutyrate and glutamate degradation pathways localized to the cytoplasm SAKL0C10846g 0 983761 984255 ON 3 C10846 complement(983761..984255) some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W SAKL0C10868g 1 986125 986898 ON 3 C10868 (986125..986898) weakly similar to uniprot|P53822 Saccharomyces cerevisiae YNL336W COS1, Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins SAKL0C10890g 0 987193 987702 ON 3 C10890 complement(987193..987702) weakly similar to uniprot|P38212 Saccharomyces cerevisiae YBR005W RCR1 Protein of the endoplasmic reticulum membrane involved in chitin deposition in the cell wall overproduction confers resistance to Congo Red SAKL0C10912g 1 987802 988341 ON 3 C10912 (987802..988341) no similarity SAKL0C10934g 1 989121 989693 ON 3 C10934 (989121..989693) some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W SAKL0C10956g 1 990412 990927 ON 3 C10956 (990412..990927) some similarities with uniprot|P53822 Saccharomyces cerevisiae YNL336W COS1 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins SAKL0C10978g 0 991612 992388 ON 3 C10978 complement(991612..992388) some similarities with uniprot|P47187 Saccharomyces cerevisiae YJR161C COS5 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins SAKL0C11000g 1 994275 995474 ON 3 C11000 (994275..995474) similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite SAKL0C11022g 1 995930 996253 ON 3 C11022 (995930..996253) conserved hypothetical protein SAKL0C11044g 1 997057 998364 ON 3 C11044 (997057..998364) similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis the authentic non-tagged protein was localized to mitochondria SAKL0C11066g 0 998593 1000335 ON 3 C11066 complement(998593..1000335) similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C SAKL0C11088g 1 1000546 1001085 ON 3 C11088 (1000546..1001085) no similarity SAKL0C11110g 0 1003048 1004490 ON 3 C11110 complement(1003048..1004490) highly similar to gnl|GLV|KLLA0E17237g Kluyveromyces lactis KLLA0E17237g and similar to YBR003W uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis SAKL0C11132g 1 1004720 1005595 ON 3 C11132 (1004720..1005595) highly similar to gnl|GLV|KLLA0E17259g Kluyveromyces lactis KLLA0E17259g and similar to YBR002C uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis- prenyltransferase involved in dolichol synthesis participates in endoplasmic reticulum (ER) protein sorting SAKL0C11154g 0 1005780 1006382 ON 3 C11154 complement(1005780..1006382) similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Yeast Ran Binder #1 suppressor of FUS1 homolog of mouse HTF9a and human RanBP1 nuclear GTPase- activating protein for Ran SAKL0C11176g 1 1006609 1008849 ON 3 C11176 (1006609..1008849) highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C NTH1 Neutral trehalase degrades trehalose required for thermotolerance and may mediate resistance to other cellular stresses may be phosphorylated by Cdc28p Sklu_CEN3 0 1009330 1009526 ON 3 CEN3 complement(1009330..1009526) Chromosome III centromere SAKL0C11220g 1 1010601 1010985 ON 3 C11220 (1010601..1010642,1010713..1010985) highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis, member GLR.3502 SAKL0C11242g 0 1011163 1011558 ON 3 C11242 complement(1011163..1011558) similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation SAKL0C11264g 1 1012055 1012453 ON 3 C11264 (1012055..1012453) similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p SAKL0C11286g 0 1012631 1013917 ON 3 C11286 complement(1012631..1013917) highly similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation SAKL0C11308g 1 1014118 1014837 ON 3 C11308 (1014118..1014837) similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins likely component of the INO80 complex which is an ATP-dependent chromatin-remodeling complex SAKL0C11330g 0 1015136 1022605 ON 3 C11330 complement(1015136..1022605) similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Possible snoRNA-binding protein based on computational analysis of large-scale protein-protein interaction data SAKL0C11352g 0 1022989 1024749 ON 3 C11352 complement(1022989..1024749) similar to uniprot|Q05325 Saccharomyces cerevisiae YDL003W MCD1 Essential protein required for sister chromatid cohesion in mitosis and meiosis subunit of the cohesin complex expression is cell cycle regulated and peaks in S phase SAKL0C11374g 0 1025308 1025784 ON 3 C11374 complement(1025308..1025784) highly similar to uniprot|Q12165 Saccharomyces cerevisiae YDL004W ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0C11396g 1 1026123 1027109 ON 3 C11396 (1026123..1027109) weakly similar to uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex SAKL0C11418g 0 1027172 1028056 ON 3 C11418 complement(1027172..1028056) highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C) inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p mutation delays mitochondrial inheritance deletion reveals defects in precursor tRNA splicing sporulation and cell separation SAKL0C11440g 0 1028353 1029736 ON 3 C11440 complement(1028353..1029660,1029734..1029736) highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for normal peptide hydrolysis by the core 20S particle Sklu_3.trna17S 1 1031766 1031873 ON 3 tS-AGA (1031766..1031802,1031829..1031873) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0C11528g 0 1032161 1033264 ON 3 C11528 complement(1032161..1033264) highly similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase synthesizes glucose-1-phosphate and UDP- galactose from UDP-D-glucose and alpha-D-galactose-1- phosphate in the second step of galactose catabolism SAKL0C11550g 0 1033898 1035958 ON 3 C11550 complement(1033898..1035958) similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta- anomers SAKL0C11572g 1 1036331 1037857 ON 3 C11572 (1036331..1037857) similar to uniprot|P04385 Saccharomyces cerevisiae YBR020W GAL1 Galactokinase phosphorylates alpha-D- galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism expression regulated by Gal4p and similar to YDR009W uniprot|P13045 Saccharomyces cerevisiae YDR009W GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose forms a complex with Gal80p and Gal4p to relieve inhibition by Gal80p binds galactose and ATP but does not have galactokinase activity SAKL0C11594g 0 1038296 1040104 ON 3 C11594 complement(1038296..1040104) highly similar to uniprot|P05316 YBR021W Saccharomyces cerevisiae FUR4 Uracil permease localized to the plasma membrane SAKL0C11616g 0 1041794 1046248 ON 3 C11616 complement(1041794..1046248) highly similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter SAKL0C11638g 0 1046453 1046905 ON 3 C11638 complement(1046453..1046905) no similarity SAKL0C11660g 0 1047145 1048329 ON 3 C11660 complement(1047145..1048329) some similarities with uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p SAKL0C11682g 1 1049450 1050004 ON 3 C11682 (1049450..1050004) similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP- ribose 1''-phosphate a tRNA splicing metabolite may have a role in regulation of tRNA splicing SAKL0C11704g 1 1050447 1054979 ON 3 C11704 (1050447..1054979) similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W PDR15 SAKL0C11726g 0 1056018 1059587 ON 3 C11726 complement(1056018..1059587) similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan SAKL0C11748g 1 1060183 1061550 ON 3 C11748 (1060183..1061550) uniprot|Q96W94 Saccharomyces kluyveri PYD3 Beta- alanine synthase SAKL0C11770g 0 1061740 1064583 ON 3 C11770 complement(1061740..1064583) highly similar to gnl|GLV|KLLA0D03542g Kluyveromyces lactis KLLA0D03542g and similar to YBR038W uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis SAKL0C11792g 1 1065249 1066181 ON 3 C11792 (1065249..1066181) similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C SAKL0C11814g 0 1066399 1067580 ON 3 C11814 complement(1066399..1067580) highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF Sklu_3.trna18G 0 1069427 1069498 ON 3 tG-UCC complement(1069427..1069498) tRNA Type: Gly (G) | Anti-Codon: UCC | Cove Score: 66.72 SAKL0C11913g1 0 1069940 1075208 ON 3 C11913 complement(1069940..1073905,1073907..1075208) Retrotransposon Gag and Pol genes SAKL0C11913g2 0 1073886 1075208 ON 3 C11913 complement(1073886..1075208) Retrotransposon Gag gene co-transcribed with Pol Sklu_3.trna19G 1 1075697 1075768 ON 3 tG-UCC (1075697..1075768) tRNA Type: Gly (G) | Anti-Codon: UCC | Cove Score: 66.72 SAKL0C11968g 0 1075992 1076834 ON 3 C11968 complement(1075992..1076834) weakly similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p may be involved in U2 snRNA folding contains two RNA recognition motifs (RRMs) SAKL0C11990g 0 1077112 1079889 ON 3 C11990 complement(1077112..1079889) highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo SAKL0C12012g 0 1080199 1081326 ON 3 C12012 complement(1080199..1081326) similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4- NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p SAKL0C12034g 0 1081841 1082164 ON 3 C12034 complement(1081841..1082164) no similarity SAKL0C12056g 0 1082289 1082795 ON 3 C12056 complement(1082289..1082795) no similarity SAKL0C12100g 0 1083684 1084628 ON 3 C12100 complement(1083684..1084628) similar to gnl|GLV|CAGL0E02233g Candida glabrata CAGL0E02233g and some similarites with YNL289W uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth SAKL0C12122g 1 1086281 1088116 ON 3 C12122 (1086281..1088116) similar to uniprot|P39980 Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates transcription is induced during iron deprivation and diauxic shift potentially phosphorylated by Cdc28p SAKL0C12144g 0 1088849 1089838 ON 3 C12144 complement(1088849..1089838) highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon Sklu_3.trna20S 1 1090880 1090982 ON 3 tS-GCU (1090880..1090916,1090938..1090982) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 67.77 SAKL0C12210g 1 1091093 1092682 ON 3 C12210 (1091093..1092682) similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein SAKL0C12232g 0 1093069 1094283 ON 3 C12232 complement(1093069..1094283) similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase SAKL0C12254g 0 1094427 1095245 ON 3 C12254 complement(1094427..1095245) similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane SAKL0C12276g 1 1095349 1095954 ON 3 C12276 (1095349..1095954) similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C Hypothetical ORF SAKL0C12298g 0 1096026 1097756 ON 3 C12298 complement(1096026..1097756) similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W SAKL0C12320g 1 1098195 1099796 ON 3 C12320 (1098195..1099796) similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH SAKL0C12342g 0 1099949 1101607 ON 3 C12342 complement(1099949..1101607) similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W Hypothetical ORF SAKL0C12364g 1 1103408 1108270 ON 3 C12364 (1103408..1108270) similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins SAKL0C12386g 0 1108341 1110923 ON 3 C12386 complement(1108341..1110923) similar to uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42 SAKL0C12408g 1 1111709 1112218 ON 3 C12408 (1111709..1112218) similar to gnl|GLV|KLLA0A07381g Kluyveromyces lactis KLLA0A07381g and some similarites with YOL114C uniprot|Q12322 Saccharomyces cerevisiae YOL114C Hypothetical ORF SAKL0C12430g 0 1112285 1114228 ON 3 C12430 complement(1112285..1114228) similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation SAKL0C12452g 0 1114754 1116070 ON 3 C12452 complement(1114754..1116070) some similarities with uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus SAKL0C12474g 0 1116825 1117124 ON 3 C12474 complement(1116825..1117124) similar to uniprot|P48560 Saccharomyces cerevisiae YNL300W Glycosylphosphatidylinositol-dependent cell wall protein SAKL0C12496g 0 1117592 1119505 ON 3 C12496 complement(1117592..1119505) weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit SAKL0C12518g 1 1119664 1120221 ON 3 C12518 (1119664..1120221) highly similar to uniprot|Q75AS4 Ashbya gossypii ADL154C ADL154Cp and some similarities with uniprot|P38013 Saccharomyces cerevisiae YLR109w AHP1 Alkyl hydroperoxide reductase SAKL0C12540g 1 1121138 1122649 ON 3 C12540 (1121138..1122649) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0C12562g 1 1124380 1125257 ON 3 C12562 (1124380..1124491,1124809..1125257) highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A and highly similar to uniprot|P07279 Saccharomyces cerevisiae YNL301C RPL18B, proteins component of the large (60S) ribosomal subunit SAKL0C12584g 1 1126080 1127029 ON 3 C12584 (1126080..1126099,1126612..1127029) highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps19Bp and has similarity to rat S19 ribosomal protein Sklu_3.trna21I 0 1127314 1127387 ON 3 tI-AAU complement(1127314..1127387) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0C12650g 1 1128690 1130492 ON 3 C12650 (1128690..1130492) similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter SAKL0C12672g 0 1130702 1132357 ON 3 C12672 complement(1130702..1132357) weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences SAKL0C12694g 1 1133970 1135289 ON 3 C12694 (1133970..1135289) highly similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0C12716g 0 1135452 1136720 ON 3 C12716 complement(1135452..1136720) similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells SAKL0C12738g 0 1137272 1138699 ON 3 C12738 complement(1137272..1138699) similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W Hypothetical ORF SAKL0C12760g 1 1139165 1140268 ON 3 C12760 (1139165..1140268) similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in gluconeogenesis and glyoxylate cycle SAKL0C12782g 1 1140618 1141655 ON 3 C12782 (1140618..1141655) similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Hypothetical ORF SAKL0C12804g 0 1141834 1142686 ON 3 C12804 complement(1141834..1142249,1142674..1142686) highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit SAKL0C12826g 0 1142708 1143130 ON 3 C12826 complement(1142708..1143130) no similarity SAKL0C12848g 0 1143539 1144174 ON 3 C12848 complement(1143539..1144174) similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit essential for viability unlike most other mitoribosomal proteins SAKL0C12870g 1 1145051 1146142 ON 3 C12870 (1145051..1146142) highly similar to uniprot|P21965 Saccharomyces cerevisiae YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family SAKL0C12892g 0 1146462 1147097 ON 3 C12892 complement(1146462..1147097) similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68 SAKL0C12914g 1 1147438 1149165 ON 3 C12914 (1147438..1149165) similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis physically and functionally interacts with Krr1p SAKL0C12936g 0 1149302 1151731 ON 3 C12936 complement(1149302..1151731) similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter expression and turnover are regulated by Mg(2+) concentration overexpression confers increased tolerance to Al(3+) and Ga(3+) ions and similar to YFL050C uniprot|P43553 Saccharomyces cerevisiae YFL050C ALR2 Probable Mg(2+)transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions SAKL0C12958g 0 1152309 1153409 ON 3 C12958 complement(1152309..1153409) weakly similar to uniprot|P42845 Saccharomyces cerevisiae YNL309W STB1 Protein with a role in regulation of MBF-specific transcription at Start phosphorylated by Cln-Cdc28p kinases in vitro unphosphorylated form binds Swi6p and binding is required for Stb1p function expression is cell-cycle regulated SAKL0C12980g 1 1153460 1154005 ON 3 C12980 (1153460..1154005) some similarities with uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Essential component of the mitochondrial import system zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix SAKL0C13002g 1 1154629 1156881 ON 3 C13002 (1154629..1156881) similar to gnl|GLV|KLLA0E07315g Kluyveromyces lactis KLLA0E07315g and weakly similar to YNL311C uniprot|P42843 Saccharomyces cerevisiae YNL311C F-box protein SAKL0C13024g 0 1156990 1158456 ON 3 C13024 complement(1156990..1158456) similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall SAKL0C13046g 0 1158803 1159730 ON 3 C13046 complement(1158803..1159641,1159724..1159730) similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination SAKL0C13068g 1 1159968 1162676 ON 3 C13068 (1159968..1162676) similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C Protein required for cell viability SAKL0C13090g 0 1162779 1163117 ON 3 C13090 complement(1162779..1163117) no similarity SAKL0C13112g 0 1163228 1164139 ON 3 C13112 complement(1163228..1164139) some similarities with uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate contains an UISALL DNA-binding a transcriptional activation and a coiled-coil domain SAKL0C13134g 1 1164301 1165302 ON 3 C13134 (1164301..1165302) similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase SAKL0C13156g 1 1165479 1166492 ON 3 C13156 (1165479..1166492) similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase catalyzes the conversion of prephanate to phenylpyruvate which is a step in the phenylalanine biosynthesis pathway SAKL0C13178g 0 1166576 1166992 ON 3 C13178 complement(1166576..1166992) similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin- F-box ubiquitin protein ligases (SCF) required for Gic2p Far1p Sic1p and Cln2p degradation may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF SAKL0C13200g 1 1167325 1168065 ON 3 C13200 (1167325..1168065) similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C SAKL0C13222g 1 1168190 1170058 ON 3 C13222 (1168190..1170058) conserved hypothetical protein SAKL0C13244g 1 1170459 1171667 ON 3 C13244 (1170459..1171667) similar to uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase has negligible fructose-2 6-bisphosphatase activity inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate expression induced by glucose and sucrose transcriptional regulation involves protein kinase A SAKL0C13266g 0 1171961 1173340 ON 3 C13266 complement(1171961..1173340) highly similar to uniprot|Q75AV4 Ashbya gossypii ADL184W PSF2 Polyadenylation factor subunit 2 and similar to YNL317W uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex SAKL0C13288g 0 1174128 1175525 ON 3 C13288 complement(1174128..1175525) similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments ORF exhibits genomic organization compatible with a translational readthrough- dependent mode of expression SAKL0C13310g 1 1175707 1176357 ON 3 C13310 (1175707..1176357) similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF SAKL0C13332g 1 1177358 1181419 ON 3 C13332 (1177358..1181419) similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C Hypothetical ORF SAKL0C13354g 0 1181423 1182283 ON 3 C13354 complement(1181423..1182283) similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Hypothetical ORF SAKL0C13376g 1 1182675 1183304 ON 3 C13376 (1182675..1183304) highly similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p) SAKL0C13398g 0 1183517 1186156 ON 3 C13398 complement(1183517..1186156) similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W Protein of unknown function potential Cdc28p substrate SAKL0C13420g 1 1186611 1187381 ON 3 C13420 (1186611..1187381) weakly similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor SAKL0C13442g 0 1187591 1188865 ON 3 C13442 complement(1187591..1188865) highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine SAKL0C13464g 0 1189230 1190480 ON 3 C13464 complement(1189230..1190480) similar to uniprot|P42838 YNL323W Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER SAKL0C13486g 1 1190962 1191189 ON 3 C13486 (1190962..1191189) no similarity SAKL0C13508g 1 1191386 1192864 ON 3 C13508 (1191386..1192864) similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C SNG1 Protein involved in nitrosoguanidine resistance and weakly similar to YJR015W uniprot|P47090 Saccharomyces cerevisiae YJR015W Hypothetical ORF SAKL0C13530g 0 1192946 1195039 ON 3 C13530 complement(1192946..1195039) similar to similar to uniprot|Q08282 YOL141w Saccharomyces cerevisiae PPM2 Putative carboxyl methyl transferase SAKL0C13552g 1 1195424 1198033 ON 3 C13552 (1195424..1198033) similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Protein required for efficient mating member of a family of eukaryotic proteins that contain a domain homologous to Sac1p SAKL0C13574g 0 1198076 1198804 ON 3 C13574 complement(1198076..1198804) highly similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Ribosomal RNA Processing Rrp40p SAKL0C13596g 1 1198957 1199958 ON 3 C13596 (1198957..1199958) similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p one of three yeast DHHC-cysteine rich domain proteins (Pfa3p Erf2p Akr1p) with palmitoyltransferase activity required for vacuolar integrity under stress conditions SAKL0C13618g 0 1200134 1202482 ON 3 C13618 complement(1200134..1202482) weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)- anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner SAKL0C13640g 0 1202648 1202914 ON 3 C13640 complement(1202648..1202914) no similarity SAKL0C13662g 1 1203489 1203917 ON 3 C13662 (1203489..1203917) similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Protein of the mitochondrial inner membrane function partially overlaps that of Mdj1p which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix member of the DnaJ family SAKL0C13684g 1 1204367 1207471 ON 3 C13684 (1204367..1207471) similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 Required for peroxisome assembly Member of the AAA-protein family that includes NSFp and PEX1p SAKL0C13706g 1 1207800 1209101 ON 3 C13706 (1207800..1209101) highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase regulates transcription and silencing SAKL0C13728g 1 1209426 1209935 ON 3 C13728 (1209426..1209935) highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6 7-dimethyl-8- ribityllumazine synthase also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin SAKL0C13750g 0 1210007 1211494 ON 3 C13750 complement(1210007..1211494) similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis SAKL0C13772g 1 1211712 1214984 ON 3 C13772 (1211712..1214984) similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes including cyclin genes contains TPR repeats SAKL0C13794g 0 1215044 1215598 ON 3 C13794 complement(1215044..1215598) highly similar to gnl|GLV|KLLA0E01892g Kluyveromyces lactis KLLA0E01892g and similar to YOL146W uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery SAKL0C13816g 1 1215817 1216509 ON 3 C13816 (1215817..1216509) similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation most abundant protein in the peroxisomal membrane regulated by Adr1p and Pip2p-Oaf1p promoter contains ORE and UAS1-like elements SAKL0C13838g 1 1216729 1218522 ON 3 C13838 (1216729..1218522) similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex involved in maintaining the integrity of the complex SAKL0C13860g 0 1218563 1219198 ON 3 C13860 complement(1218563..1219198) highly similar to gnl|GLV|KLLA0E01826g Kluyveromyces lactis KLLA0E01826g and similar to YOL149W uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Decapping enzyme essential phosphoprotein component of mRNA decapping complex plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation regulated by DEAD box protein Dhh1p SAKL0C13882g 1 1221149 1222888 ON 3 C13882 (1221149..1222888) some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments SAKL0C13904g 1 1223973 1224992 ON 3 C13904 (1223973..1224992) similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase SAKL0C13926g 0 1228188 1229336 ON 3 C13926 complement(1228188..1229336) similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W SAKL0C13970g 1 1239443 1241182 ON 3 C13970 (1239443..1241182) highly similar to uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter active in early growth phase SAKL0C13992g 0 1242080 1243738 ON 3 C13992 complement(1242080..1243738) similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation SAKL0C14014g 1 1245903 1246265 ON 3 C14014 (1245903..1246265) some similarities with uniprot|Q7SGN2 Neurospora crassa NCU08051 Hypothetical protein NCU08051.1 SAKL0C14058g 1 1248968 1249915 ON 3 C14058 (1248968..1249915) conserved hypothetical protein SAKL0C14080g 0 1250941 1252356 ON 3 C14080 complement(1250941..1252356) no similarity SAKL0D00110g 1 1481 3169 ON 4 D00110 (1481..3169) some similarities with uniprot|Q07629 Saccharomyces cerevisiae YDL218W SAKL0D00132g 0 3749 5836 ON 4 D00132 complement(3749..5836) similar to gnl|GLV|KLLA0C18909g Kluyveromyces lactis KLLA0C18909g and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway SAKL0D00176g 0 9353 14860 ON 4 D00176 complement(9353..14860) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation cell wall protein that binds to mannose chains on the surface of other cells confers floc-forming ability that is chymotrypsin sensitive and heat resistant SAKL0D00198g 0 16135 16512 ON 4 D00198 complement(16135..16512) no similarity SAKL0D00220g 0 18466 20199 ON 4 D00220 complement(18466..20199) uniprot|Q6XAE8 Saccharomyces kluyveri Pyruvate decarboxylase-like protein SAKL0D00242g 0 21608 22660 ON 4 D00242 complement(21608..22660) similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF SAKL0D00264g 0 24754 27300 ON 4 D00264 complement(24754..27300) similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p SAKL0D00286g 1 27500 28003 ON 4 D00286 (27500..28003) similar to uniprot|P11747 Saccharomyces cerevisiae YML098W SAKL0D00308g 0 28069 29730 ON 4 D00308 complement(28069..29730) similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum SAKL0D00330g 0 29895 31202 ON 4 D00330 complement(29895..31202) similar to uniprot|P54787 Saccharomyces cerevisiae YML097C SAKL0D00352g 1 31387 32934 ON 4 D00352 (31387..32934) similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Hypothetical ORF SAKL0D00374g 0 32939 33553 ON 4 D00374 complement(32939..33553) similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p) cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) homolog of human XPF protein SAKL0D00396g 1 33694 34258 ON 4 D00396 (33694..33709,33774..34258) highly similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it SAKL0D00418g 1 34574 37228 ON 4 D00418 (34574..37228) similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0D00440g 0 37327 38141 ON 4 D00440 complement(37327..38035,38098..38141) highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 20S proteasome beta-type subunit SAKL0D00462g 0 38517 38924 ON 4 D00462 complement(38517..38924) conserved hypothetical protein SAKL0D00484g 1 39205 40008 OFF 4 D00484 (39205..40008) conserved hypothetical protein Sklu_YGOB_Anc_8.869 1 39275 40008 ON 4 Anc_8.869 (39275..39280,39349..40008) ANNOTATED BY YGOB - Replaces SAKL0D00484g to add intron. SAKL0D00506g 1 40202 40294 OFF 4 D00506 (40202..40294) conserved hypothetical protein SAKL0D00528g 0 40574 42133 ON 4 D00528 complement(40574..42133) similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc1 mutants are defective in directing meiotic recombination events to homologous chromatids SAKL0D00550g 1 42478 44229 ON 4 D00550 (42478..44229) similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway SAKL0D00572g 0 44550 48080 ON 4 D00572 complement(44550..48080) similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein component of mitochondrial RNase P along with the mitochondrially-encoded RNA subunit RPM1 Rnase P removes 5' extensions from tRNA precursors Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs SAKL0D00594g 0 48583 50132 ON 4 D00594 complement(48583..49875,50031..50132) highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis Sklu_4.trna1I 1 53326 53399 ON 4 tI-AAU (53326..53399) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0D00704g 1 53852 55861 ON 4 D00704 (53852..55861) similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1- Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation SAKL0D00726g 0 55984 56916 ON 4 D00726 complement(55984..56916) highly similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability SAKL0D00748g 0 57500 59086 ON 4 D00748 complement(57500..59086) highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D- erythroascorbic acid which is protective against oxidative stress SAKL0D00770g 1 59374 60612 ON 4 D00770 (59374..60612) conserved hypothetical protein SAKL0D00792g 0 60876 62474 ON 4 D00792 complement(60876..62194,62450..62474) highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta- tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules SAKL0D00814g 0 63086 64798 ON 4 D00814 complement(63086..64798) highly similar to gnl|GLV|KLLA0C16852g Kluyveromyces lactis KLLA0C16852g and similar to uniprot|P25297 YML123C Saccharomyces cerevisiae PHO84 High- affinity inorganic phosphate (Pi) transporter and low- affinity manganese transporter SAKL0D00836g 0 65731 67536 ON 4 D00836 complement(65731..67536) similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source SAKL0D00858g 0 68262 69575 ON 4 D00858 complement(68262..69575) conserved hypothetical protein SAKL0D00880g 0 69853 70743 ON 4 D00880 complement(69853..70743) conserved hypothetical protein SAKL0D00902g 0 70897 72222 ON 4 D00902 complement(70897..72222) similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase) joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway Sklu_4.trna2Q 0 72741 72812 ON 4 tQ-UUG complement(72741..72812) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D01012g 0 74360 74938 ON 4 D01012 complement(74360..74938) similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially- localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration SAKL0D01034g 1 75089 75988 ON 4 D01034 (75089..75988) highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs SAKL0D01056g 0 76283 77824 ON 4 D01056 complement(76283..77824) highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae SAKL0D01078g 1 78360 81170 ON 4 D01078 (78360..81170) similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs SAKL0D01100g 0 81235 84057 ON 4 D01100 complement(81235..84057) weakly similar to uniprot|P33200 Saccharomyces cerevisiae YBL005W PDR3 Transcriptional activator of the pleiotropic drug resistance network regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements) SAKL0D01122g 1 84647 85582 ON 4 D01122 (84647..85582) conserved hypothetical protein SAKL0D01144g 0 85723 85977 ON 4 D01144 complement(85723..85977) highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit SAKL0D01166g 1 86218 87735 ON 4 D01166 (86218..87735) similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C SAKL0D01188g 0 87783 89528 ON 4 D01188 complement(87783..89528) similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes SAKL0D01210g 0 89856 90146 ON 4 D01210 complement(89856..90146) some similarities with uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance interacts with sodium:hydrogen antiporter Nha1p member of a family of conserved often subtelomerically- encoded proteins SAKL0D01232g 0 90918 92642 ON 4 D01232 complement(90918..92642) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane SAKL0D01254g 1 95413 96000 ON 4 D01254 (95413..96000) some similarities with uniprot|Q07788 Saccharomyces cerevisiae YDL248W COS7 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins SAKL0D01276g 1 96411 97919 ON 4 D01276 (96411..97919) similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase SAKL0D01298g 1 98188 99843 ON 4 D01298 (98188..99843) weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'- untranslated leader SAKL0D01320g 0 99898 100680 ON 4 D01320 complement(99898..100680) similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de-N-acetylation of the N- acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp SAKL0D01342g 1 101095 104907 ON 4 D01342 (101095..104907) similar to uniprot|Q75DZ4 Ashbya gossypii ABL121C ABL121Cp and similar to YMR280C uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator SAKL0D01364g 1 105477 108725 ON 4 D01364 (105477..108725) similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data SAKL0D01386g 1 109619 111184 ON 4 D01386 (109619..111184) uniprot|Q875S7 Saccharomyces kluyveri ATR1 SAKL0D01408g 1 112123 113643 ON 4 D01408 (112123..113643) weakly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates SAKL0D01430g 0 113921 115264 ON 4 D01430 complement(113921..115264) similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N- glycosylation SAKL0D01452g 0 115954 116937 ON 4 D01452 complement(115954..116937) highly similar to uniprot|Q08985 Saccharomyces cerevisiae YPL273W SAM4 S-adenosylmethionine-homocysteine methyltransferase functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio SAKL0D01474g 0 117178 119052 ON 4 D01474 complement(117178..119052) similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF SAKL0D01496g 0 120202 122268 ON 4 D01496 complement(120202..122268) similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase SAKL0D01518g 0 122448 124172 ON 4 D01518 complement(122448..124172) weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation SAKL0D01540g 0 124423 125520 ON 4 D01540 complement(124423..125520) similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin- binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome SAKL0D01562g 1 126163 126819 ON 4 D01562 (126163..126819) some similarities with uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding SAKL0D01584g 1 127275 128177 ON 4 D01584 (127275..128177) similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing SAKL0D01606g 1 128435 131161 ON 4 D01606 (128435..131161) uniprot|Q875N4 Saccharomyces kluyveri BUL2 SAKL0D01628g 0 131292 132179 ON 4 D01628 complement(131292..132179) highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1 4- benzoquinone methyltransferase involved in ubiquinone (Coenzyme Q) biosynthesis located in mitochondria Sklu_4.trna3P 0 132386 132489 ON 4 tP-UGG complement(132386..132421,132454..132489) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.75 SAKL0D01672g 1 133061 133675 ON 4 D01672 (133061..133675) conserved hypothetical protein SAKL0D01694g 1 134284 135240 ON 4 D01694 (134284..135240) similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease SAKL0D01716g 1 135836 138664 ON 4 D01716 (135836..138664) similar to uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p SAKL0D01738g 1 138687 139223 ON 4 D01738 (138687..139223) similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha- beta sandwiches. SAKL0D01760g 1 140050 141195 ON 4 D01760 (140050..141195) similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme Sklu_4.trna4Q 1 141456 141527 ON 4 tQ-UUG (141456..141527) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D01804g 0 141732 142721 ON 4 D01804 complement(141732..142721) weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery SAKL0D01826g 1 142979 143653 ON 4 D01826 (142979..143653) highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1 Sklu_4.trna5D 1 144170 144241 ON 4 tD-GUC (144170..144241) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0D01870g 0 144409 145212 ON 4 D01870 complement(144409..145212) similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19 SAKL0D01892g 1 145424 146530 ON 4 D01892 (145424..146530) similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit SAKL0D01914g 0 146546 149968 ON 4 D01914 complement(146546..149968) similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds SAKL0D01936g 0 150359 151009 ON 4 D01936 complement(150359..151009) conserved hypothetical protein SAKL0D01958g 1 151411 154248 ON 4 D01958 (151411..154248) some similarities with uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling SAKL0D01980g 0 154349 159214 ON 4 D01980 complement(154349..159214) similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC) SAKL0D02002g 0 159453 160355 ON 4 D02002 complement(159453..160355) similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate SAKL0D02024g 0 161023 163716 ON 4 D02024 complement(161023..163716) similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein. SAKL0D02046g 1 164962 166461 ON 4 D02046 (164962..166461) similar to uniprot|Q756I0 Ashbya gossypii AER281C AER281Cp and weakly similar to YMR265C uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF SAKL0D02068g 1 167213 168823 ON 4 D02068 (167213..168823) similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans SAKL0D02090g 0 169253 169864 ON 4 D02090 complement(169253..169864) similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination SAKL0D02112g 0 170051 170560 ON 4 D02112 complement(170051..170560) similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci SAKL0D02134g 0 170670 171590 ON 4 D02134 complement(170670..171590) similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF SAKL0D02156g 1 171759 175208 ON 4 D02156 (171759..175208) similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6- phosphate synthase/phosphatase complex SAKL0D02178g 1 175434 175895 ON 4 D02178 (175434..175895) highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A SAKL0D02200g 0 176085 177164 ON 4 D02200 complement(176085..177164) conserved hypothetical protein SAKL0D02222g 1 177348 181625 ON 4 D02222 (177348..181625) similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Hypothetical ORF Sklu_4.trna6N 1 183057 183130 ON 4 tN-GUU (183057..183130) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0D02310g 1 183271 184920 ON 4 D02310 (183271..184920) similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C Hypothetical ORF SAKL0D02332g 1 185390 187783 ON 4 D02332 (185390..187783) uniprot|O59926 Saccharomyces kluyveri PET111 COX2 mRNA- specific translational activator Pet111p SAKL0D02354g 1 188524 189519 ON 4 D02354 (188524..189519) weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p- binding protein Sklu_YGOB_Anc_8.807 1 189947 190129 ON 4 Anc_8.807 (189947..190129) ANNOTATED BY YGOB - SAKL0D02376g 0 190817 191035 ON 4 D02376 complement(190817..191035) no similarity SAKL0D02398g 1 191166 192134 ON 4 D02398 (191166..192134) similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W Hypothetical ORF SAKL0D02420g 0 192185 192907 ON 4 D02420 complement(192185..192907) similar to uniprot|Q04839 Saccharomyces cerevisiae YMR255W GFD1 Coiled-coiled protein of unknown function identified as a high-copy suppressor of a dbp5 mutation SAKL0D02442g 1 193585 194727 ON 4 D02442 (193585..194727) similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D02464g 1 195096 195464 ON 4 D02464 (195096..195464) similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF SAKL0D02486g 0 195646 197499 ON 4 D02486 complement(195646..197499) weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase SAKL0D02508g 1 197981 199720 ON 4 D02508 (197981..199720) similar to gnl|GLV|KLLA0D12606g Kluyveromyces lactis KLLA0D12606g and weakly similar to YNR055C uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane- spanning domains permit nonselective cation uptake SAKL0D02530g 1 200047 200865 ON 4 D02530 (200047..200865) highly similar to uniprot|Q750Z0 Ashbya gossypii AGL203C AGL203Cp and similar to YDR054C uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin- conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation SAKL0D02552g 1 201078 201539 ON 4 D02552 (201078..201539) similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization possible component of the TOR nutrient signaling pathway gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4- phosphate kinase SAKL0D02574g 1 202241 203965 ON 4 D02574 (202241..203965) similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex required for Cdc7p kinase activity and initiation of DNA replication phosphorylates the Mcm2-7 family of proteins cell cycle regulated SAKL0D02596g 1 204347 206599 ON 4 D02596 (204347..206599) conserved hypothetical protein SAKL0D02618g 0 208093 209058 ON 4 D02618 complement(208093..209058) some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0D02640g 1 215909 219292 ON 4 D02640 (215909..219292) similar to uniprot|P53753 Saccharomyces cerevisiae YNR067C SAKL0D02662g 0 219840 220949 ON 4 D02662 complement(219840..220949) similar to uniprot|P38246 Saccharomyces cerevisiae YBR076W ECM8 Non-essential protein of unknown function SAKL0D02684g 1 221650 223746 ON 4 D02684 (221650..223746) conserved hypothetical protein SAKL0D02706g 0 224106 227027 ON 4 D02706 complement(224106..227027) similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF SAKL0D02728g 1 227437 228552 ON 4 D02728 (227437..228552) highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents SAKL0D02750g 1 228671 230677 ON 4 D02750 (228671..230677) similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF SAKL0D02772g 0 230765 233524 ON 4 D02772 complement(230765..233524) similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference SAKL0D02794g 0 234153 234806 ON 4 D02794 complement(234153..234806) similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation SAKL0D02816g 0 235410 235958 ON 4 D02816 complement(235410..235958) conserved hypothetical protein SAKL0D02838g 1 236232 236912 ON 4 D02838 (236232..236912) similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases SAKL0D02860g 0 237027 237773 ON 4 D02860 complement(237027..237773) highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase SAKL0D02882g 0 238458 239399 ON 4 D02882 complement(238458..239399) highly similar to gnl|GLV|KLLA0F18810g Kluyveromyces lactis KLLA0F18810g and similar to YDR051C uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF SAKL0D02904g 1 239629 240226 ON 4 D02904 (239629..240018,240095..240226) conserved hypothetical protein SAKL0D02926g 1 240708 242459 ON 4 D02926 (240708..242459) uniprot|Q875S6 Saccharomyces kluyveri TAT1 SAKL0D02948g 1 243064 244848 ON 4 D02948 (243064..244848) similar to uniprot|P38084 Saccharomyces cerevisiae YBR068C BAP2 High-affinity leucine permease functions as a branched-chain amino acid permease involved in the uptake of leucine isoleucine and valine contains 12 predicted transmembrane domains SAKL0D02970g 1 245449 247254 ON 4 D02970 (245449..247254) uniprot|Q875S5 Saccharomyces kluyveri BAP2 SAKL0D02992g 1 247577 249343 ON 4 D02992 (247577..249343) highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis SAKL0D03014g 0 250066 251013 ON 4 D03014 complement(250066..251013) highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop SAKL0D03036g 1 251510 252124 ON 4 D03036 (251510..252124) similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins SAKL0D03058g 0 252198 252732 ON 4 D03058 complement(252198..252649,252717..252732) similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF SAKL0D03080g 0 252845 253492 ON 4 D03080 complement(252845..253492) no similarity SAKL0D03102g 0 253814 254908 ON 4 D03102 complement(253814..254908) similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p Sklu_4.trna7E 1 255926 255997 ON 4 tE-UUC (255926..255997) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0D03146g 0 256292 256765 ON 4 D03146 complement(256292..256765) similar to uniprot|Q750L1 Ashbya gossypii AGR031W AGR031Wp and some similarites with YDR043C uniprot|Q03125 Saccharomyces cerevisiae YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response SAKL0D03168g 1 258051 259034 ON 4 D03168 (258051..259034) highly similar to uniprot|P11353 YDR044W Saccharomyces cerevisiae HEM13 Coproporphyrinogen III oxidase SAKL0D03190g 0 259325 259663 ON 4 D03190 complement(259325..259663) highly similar to uniprot|Q04307 Saccharomyces cerevisiae YDR045C RPC11 RNA polymerase III subunit C11 mediates pol III RNA cleavage activity and is important for termination of transcription SAKL0D03212g 1 259895 261946 ON 4 D03212 (259895..261946) some similarities with uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex SAKL0D03234g 1 262365 264941 ON 4 D03234 (262365..264941) some similarities with uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Serine-threonine protein kinase member (with Ark1p and Prk1p) of the Ark kinase family SAKL0D03256g 1 265196 265450 ON 4 D03256 (265196..265450) similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p Lcb2p) several-fold involved in sphingolipid biosynthesis SAKL0D03278g 0 266339 267487 ON 4 D03278 complement(266339..267487) conserved hypothetical protein SAKL0D03300g 1 267853 269289 ON 4 D03300 (267853..269289) similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases SAKL0D03322g 1 270137 272434 ON 4 D03322 (270137..272434) similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains SAKL0D03344g 1 273211 274083 ON 4 D03344 (273211..274083) similar to uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation SAKL0D03366g 0 274584 275702 ON 4 D03366 complement(274584..275702) highly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino- heptulosonate-7- phosphate (DAHP) synthase Sklu_YGOB_YBR056W-A 0 276109 276282 ON 4 YBR056W-A complement(276109..276282) ANNOTATED BY YGOB - Sklu_4.trna8Q 0 277097 277168 ON 4 tQ-UUG complement(277097..277168) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D03410g 0 277688 279166 ON 4 D03410 complement(277688..279166) similar to uniprot|P38081 YBR056W Saccharomyces cerevisiae Hypothetical ORF Sklu_4.trna9D 0 279514 279585 ON 4 tD-GUC complement(279514..279585) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 Sklu_4.trna10L 0 280424 280507 ON 4 tL-UAA complement(280424..280507) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 69.31 SAKL0D03564g 1 287287 290013 ON 4 D03564 (287287..290013) similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex SAKL0D03586g 1 290224 292629 ON 4 D03586 (290224..292629) similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer SAKL0D03608g 0 292726 294027 ON 4 D03608 complement(292726..294027) conserved hypothetical protein SAKL0D03630g 1 294208 295776 ON 4 D03630 (294208..295776) similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF SAKL0D03652g 0 297318 298271 ON 4 D03652 complement(297318..298271) similar to uniprot|P38079 Saccharomyces cerevisiae YBR054W YRO2 Putative plasma membrane protein of unknown function transcriptionally regulated by Haa1p green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud SAKL0D03674g 1 300135 301160 ON 4 D03674 (300135..301160) similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Hypothetical ORF SAKL0D03696g 1 301531 302127 ON 4 D03696 (301531..302127) highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D03718g 0 302325 302660 ON 4 D03718 complement(302325..302660) similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W Hypothetical ORF SAKL0D03740g 1 303240 304676 ON 4 D03740 (303240..304676) similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSA protein SAKL0D03762g 1 305223 307889 ON 4 D03762 (305223..307889) similar to gnl|GLV|CAGL0K11814g Candida glabrata CAGL0K11814g and weakly similar to YDR028C uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing SAKL0D03784g 1 308125 310977 ON 4 D03784 (308125..310977) similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex SAKL0D03806g 1 311186 312955 ON 4 D03806 (311186..312955) similar to uniprot|Q12457 Saccharomyces cerevisiae YDR026C Hypothetical ORF SAKL0D03828g 0 313174 314026 ON 4 D03828 complement(313174..313599,313982..314026) highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025w RPS18A or uniprot|P26781 Saccharomyces cerevisiae YBR048w RPS18B ribosomal protein SAKL0D03850g 0 314664 315206 ON 4 D03850 complement(314664..315206) some similarities with uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23 The authentic non-tagged protein was localized to the mitochondria SAKL0D03872g 1 316127 317173 ON 4 D03872 (316127..317173) highly similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C SAKL0D03883g 1 317434 319494 ON 4 D03883 (317434..319494) some similarities with uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific regulatory subunit of the Glc7p protein phosphatase SAKL0D03894g 0 319590 320978 ON 4 D03894 complement(319590..320978) highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase Sklu_4.trna11V 1 321331 321404 ON 4 tV-UAC (321331..321404) tRNA Type: Val (V) | Anti-Codon: UAC | Cove Score: 71.06 SAKL0D03938g 1 321543 321968 ON 4 D03938 (321543..321968) conserved hypothetical protein SAKL0D03960g 0 321960 323156 ON 4 D03960 complement(321960..323156) highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases SAKL0D03982g 1 323389 324024 ON 4 D03982 (323389..324024) similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C Hypothetical ORF SAKL0D04004g 1 324588 326264 ON 4 D04004 (324588..326264) similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone SAKL0D04026g 1 326569 327738 ON 4 D04026 (326569..327738) highly similar to gnl|GLV|KLLA0B06754g Kluyveromyces lactis and similar to YDR019C, uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1), SAKL0D04048g 1 328883 330643 ON 4 D04048 (328883..330643) similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p SAKL0D04070g 1 331254 333257 ON 4 D04070 (331254..333257) similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) SAKL0D04092g 1 333811 334971 ON 4 D04092 (333811..334971) similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C Hypothetical ORF SAKL0D04114g 0 335097 337112 ON 4 D04114 complement(335097..337112) similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids SAKL0D04136g 0 337392 338267 ON 4 D04136 complement(337392..338267) similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating SAKL0D04158g 0 339074 339946 ON 4 D04158 complement(339074..339946) highly similar to gnl|GLV|KLLA0B06886g Kluyveromyces lactis KLLA0B06886g and similar to YBR039W uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis Sklu_4.trna12D 0 340673 340744 ON 4 tD-GUC complement(340673..340744) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 Sklu_4.trna13R 0 340764 340835 ON 4 tR-UCU complement(340764..340835) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0D04246g 1 342474 345215 ON 4 D04246 (342474..345215) weakly similar to uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats SAKL0D04268g 1 345673 345990 ON 4 D04268 (345673..345990) similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore Sklu_4.trna14I 1 347497 347570 ON 4 tI-AAU (347497..347570) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0D04334g 0 347663 348406 ON 4 D04334 complement(347663..348406) conserved hypothetical protein SAKL0D04378g 1 350277 351278 ON 4 D04378 (350277..351278) similar to uniprot|Q08991 Saccharomyces cerevisiae YPL279C SAKL0D04400g 1 352122 352895 ON 4 D04400 (352122..352179,352249..352895) highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism SAKL0D04422g 0 352983 354767 ON 4 D04422 complement(352983..354767) weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity SAKL0D04444g 1 354890 355519 ON 4 D04444 (354890..355519) highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery SAKL0D04455g 0 355514 356713 ON 4 D04455 complement(355514..356713) highly similar to gb|AAS50556 Ashbya gossypii DUF890 family protein, probable methyl-transferase SAKL0D04466g 1 357282 358328 ON 4 D04466 (357282..358328) highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants SAKL0D04488g 0 358617 359705 ON 4 D04488 complement(358617..359705) highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4A SAKL0D04510g 0 360010 361605 ON 4 D04510 complement(360010..361605) similar to uniprot|P36035 Saccharomyces cerevisiae YKL217W JEN1 Lactate transporter, required for uptake of lactate and pyruvate; expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions, and repressed in the presence of glucose, fructose, and mannose SAKL0D04532g 0 362288 363961 ON 4 D04532 complement(362288..363961) similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W Hypothetical ORF Sklu_4.trna15K 1 365338 365410 ON 4 tK-CUU (365338..365410) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0D04664g 0 365852 367633 ON 4 D04664 complement(365852..367633) highly similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease; localization to the plasma membrane is regulated by nitrogen source Sklu_4.trna16P 0 368587 368690 ON 4 tP-UGG complement(368587..368622,368655..368690) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.75 Sklu_4.trna17R 1 369871 369942 ON 4 tR-UCU (369871..369942) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0D04752g 1 370120 371277 ON 4 D04752 (370120..371277) highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Putative glycoprotease that interacts with Bud32p which is a member of the novel protein kinase piD261 family SAKL0D04774g 1 371547 372356 ON 4 D04774 (371547..372356) similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle SAKL0D04796g 1 372598 374907 ON 4 D04796 (372598..374907) similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W MDV1 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission Sklu_4.trna18L 0 375127 375249 ON 4 tL-CAA complement(375127..375170,375212..375249) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.10 SAKL0D04884g 1 376802 378460 ON 4 D04884 (376802..378460) highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo SAKL0D04906g 0 378604 379224 ON 4 D04906 complement(378604..379224) highly similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway associates reversibly with the late endosome has human ortholog that may be altered in breast tumors SAKL0D04928g 0 379886 381064 ON 4 D04928 complement(379886..381064) weakly similar to uniprot|P42944 Saccharomyces cerevisiae YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p SAKL0D04950g 1 382199 382588 ON 4 D04950 (382199..382588) conserved hypothetical protein SAKL0D04972g 1 383368 388092 ON 4 D04972 (383368..388092) similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D catalyzes the hydrolysis of phosphatidylcholine producing choline and phosphatidic acid involved in Sec14p-independent secretion required for meiosis and spore formation differently regulated in secretion and meiosis SAKL0D04994g 1 388523 390439 ON 4 D04994 (388523..390439) conserved hypothetical protein SAKL0D05016g 1 390808 391242 ON 4 D05016 (390808..391242) conserved hypothetical protein SAKL0D05038g 0 391328 392062 ON 4 D05038 complement(391328..392062) similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function interacts with Gea1p and Gea2p required for localization of Gea2p computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting SAKL0D05060g 0 392306 397624 ON 4 D05060 complement(392306..397624) similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0D05082g 0 397911 400946 ON 4 D05082 complement(397911..400946) some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein predicted to have 5 transmembrane segments SAKL0D05104g 1 402641 404692 ON 4 D05104 (402641..404692) similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p SAKL0D05126g 1 405282 406589 ON 4 D05126 (405282..406589) conserved hypothetical protein SAKL0D05148g 1 407168 409429 ON 4 D05148 (407168..409429) similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3 SAKL0D05170g 1 409767 410174 ON 4 D05170 (409767..410174) similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W SAKL0D05192g 0 410913 412292 ON 4 D05192 complement(410913..412292) conserved hypothetical protein SAKL0D05214g 1 412470 414029 ON 4 D05214 (412470..414029) similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF SAKL0D05236g 0 414228 415826 ON 4 D05236 complement(414228..415826) similar to uniprot|P42950 Saccharomyces cerevisiae YJL103C Hypothetical ORF SAKL0D05258g 0 416100 418247 ON 4 D05258 complement(416100..418247) similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis SAKL0D05280g 1 418457 419218 ON 4 D05280 (418457..419218) similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37 SAKL0D05302g 0 419293 420207 ON 4 D05302 complement(419293..420207) highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a positive regulator of GCN4 expression SAKL0D05324g 1 420393 422786 ON 4 D05324 (420393..422786) similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G-like protein Sklu_4.trna19R 1 423749 423842 ON 4 tR-ACG (423749..423785,423807..423842) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 64.63 SAKL0D05390g 0 423990 425981 ON 4 D05390 complement(423990..425981) similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury SAKL0D05412g 1 426231 427922 ON 4 D05412 (426231..427922) similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization SAKL0D05434g 1 428070 430322 ON 4 D05434 (428070..430322) similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein SAKL0D05456g 1 430743 433814 ON 4 D05456 (430743..433814) similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W SAKL0D05478g 1 435029 435679 ON 4 D05478 (435029..435679) similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability SAKL0D05500g 1 435911 436381 ON 4 D05500 (435911..436381) some similarities with uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit SAKL0D05522g 1 437018 441442 ON 4 D05522 (437018..441442) similar to uniprot|O60030 Kluyveromyces lactis BCK1 MAP kinase kinase kinase and some similarites with YJL095W uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen- activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway which controls cell integrity upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p SAKL0D05544g 0 441951 444584 ON 4 D05544 complement(441951..444584) similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K /H antiporter SAKL0D05566g 0 445253 447112 ON 4 D05566 complement(445253..447112) similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward-rectifier potassium channel SAKL0D05588g 1 448828 452427 ON 4 D05588 (448828..452427) similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate SAKL0D05610g 0 452447 453883 ON 4 D05610 complement(452447..453883) similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors SAKL0D05632g 0 454557 456722 ON 4 D05632 complement(454557..456722) similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control SAKL0D05654g 1 457485 460244 ON 4 D05654 (457485..460244) weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 Possibly involved in Snf1p regulated transcriptional activation shows homology to DNA binding domain of Gal4p has a leucine zipper motif and acidic region lexA-Sip4p activates transcription SAKL0D05676g 1 460844 461884 ON 4 D05676 (460844..461884) some similarities with uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability SAKL0D05698g 1 462595 463569 ON 4 D05698 (462595..463569) highly similar to gnl|GLV|CAGL0I10791g Candida glabrata CAGL0I10791g and similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase SAKL0D05720g 0 463920 466394 ON 4 D05720 complement(463920..466394) similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase SAKL0D05742g 1 466639 468504 ON 4 D05742 (466639..468504) similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) SAKL0D05764g 0 468591 471578 ON 4 D05764 complement(468591..471578) similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate SAKL0D05786g 0 472167 472580 ON 4 D05786 complement(472167..472580) similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 whiskey (whi) mutant forms a tetramer with VPS52 VPS53 and VPS54 SAKL0D05808g 1 472993 475587 ON 4 D05808 (472993..475587) weakly similar to YKR019C, uniprot|P36115 Saccharomyces cerevisiae YKR019C (IRS4), SAKL0D05830g 1 475736 477907 ON 4 D05830 (475736..477907) highly similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF SAKL0D05852g 1 478110 479756 ON 4 D05852 (478110..479756) similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF SAKL0D05874g 0 479873 481366 ON 4 D05874 complement(479873..481366) similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes SAKL0D05896g 0 481745 483304 ON 4 D05896 complement(481745..483304) similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria SAKL0D05918g 1 483809 485080 ON 4 D05918 (483809..485080) conserved hypothetical protein SAKL0D05940g 1 485575 486198 ON 4 D05940 (485575..486198) highly similar to uniprot|Q75F92 Ashbya gossypii AAL176C AAL176Cp and similar to YKR014C uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide-binding protein SAKL0D05962g 0 486502 490149 ON 4 D05962 complement(486502..490149) similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromsome transmission SAKL0D05984g 0 490867 491499 ON 4 D05984 complement(490867..491499) some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins SAKL0D06006g 0 492616 493545 ON 4 D06006 complement(492616..493545) some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins Sklu_4.trna20A 1 494527 494599 ON 4 tA-AGC (494527..494599) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0D06050g 1 494761 496698 ON 4 D06050 (494761..496698) some similarities with uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF SAKL0D06072g 0 496710 498698 ON 4 D06072 complement(496710..498698) similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p SAKL0D06094g 1 498948 503018 ON 4 D06094 (498948..503018) some similarities with uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure SAKL0D06116g 0 503196 506885 ON 4 D06116 complement(503196..506885) similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells also required with Rec8p for cohesion and recombination during meiosis phylogenetically conserved SMC chromosomal ATPase family member Sklu_4.trna21L 0 507006 507128 ON 4 tL-CAA complement(507006..507049,507091..507128) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 51.46 SAKL0D06204g 0 508197 509504 ON 4 D06204 complement(508197..509504) similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1 SAKL0D06226g 1 510407 512254 ON 4 D06226 (510407..512254) weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2 SAKL0D06248g 0 512527 514101 ON 4 D06248 complement(512527..514101) similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p SAKL0D06270g 0 515611 516099 ON 4 D06270 complement(515611..516099) conserved hypothetical protein SAKL0D06292g 0 516584 517051 ON 4 D06292 complement(516584..517051) no similarity SAKL0D06314g 0 517151 517774 ON 4 D06314 complement(517151..517774) highly similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery SAKL0D06336g 1 517940 519718 ON 4 D06336 (517940..519718) similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N- acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p SAKL0D06358g 0 519942 521564 ON 4 D06358 complement(519942..521564) similar to gnl|GLV|KLLA0C19415g Kluyveromyces lactis KLLA0C19415g and weakly similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine SAKL0D06380g 0 522001 524490 ON 4 D06380 complement(522001..524490) similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C and to uniprot|P38150 Saccharomyces cerevisiae YBR284W Hypothetical ORFs Sklu_4.trna22C 1 525971 526042 ON 4 tC-GCA (525971..526042) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 SAKL0D06446g 0 526472 528304 ON 4 D06446 complement(526472..528304) highly similar to gnl|GLV|KLLA0C19415g Kluyveromyces lactis KLLA0C19415g and similar to uniprot|Q08579 YOR192C Saccharomyces cerevisiae Hypothetical ORF SAKL0D06468g 1 529372 530850 ON 4 D06468 (529372..530850) highly similar to gnl|GLV|KLLA0F01210g Kluyveromyces lactis KLLA0F01210g and similar to YBR263W uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial SAKL0D06490g 0 531028 531684 ON 4 D06490 complement(531028..531684) similar to uniprot|P36019 Saccharomyces cerevisiae YNL093W YPT53 Involved in vacuolar protein sorting and endocytosis GTP-binding protein of the rab family SAKL0D06512g 1 531948 537842 ON 4 D06512 (531948..537842) similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation SAKL0D06534g 0 538606 540237 ON 4 D06534 complement(538606..540091,540155..540237) similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1 homolog of the S. pombe and mammalian Chk1 checkpoint kinases Protein kinase Chk1 SAKL0D06556g 1 540407 541681 ON 4 D06556 (540407..541681) similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p SAKL0D06578g 0 541754 543034 ON 4 D06578 complement(541754..543034) similar to uniprot|Q758E5 Ashbya gossypii AEL183C AEL183Cp and weakly similar to YJL049W uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF Sklu_YGOB_Anc_1.333 1 543170 544315 OFF 4 Anc_1.333 (543170..544315) ANNOTATED BY YGOB - Sklu_YGOB_Anc_1.333b 1 543170 544612 ON 4 Anc_1.333b (543170..544312,544316..544612) ANNOTATED BY YGOB - SAKL0D06622g 0 544709 547954 ON 4 D06622 complement(544709..547954) highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus co- factor of the exosome complex required for 3' end formation of 5.8S rRNA SAKL0D06644g 0 548576 550987 ON 4 D06644 complement(548576..550987) weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p SAKL0D06666g 1 551260 552522 ON 4 D06666 (551260..552522) some similarities with uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p SAKL0D06688g 0 552575 553510 ON 4 D06688 complement(552575..553510) highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex SAKL0D06710g 0 553833 555323 ON 4 D06710 complement(553833..555323) similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane. SAKL0D06732g 0 555865 557736 ON 4 D06732 complement(555865..557736) conserved hypothetical protein SAKL0D06754g 0 560301 560993 ON 4 D06754 complement(560301..560993) similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Hypothetical ORF SAKL0D06776g 1 561887 564190 ON 4 D06776 (561887..564190) weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains SAKL0D06798g 0 564525 565790 ON 4 D06798 complement(564525..565790) similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0D06820g 1 566145 567938 ON 4 D06820 (566145..567938) similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase SAKL0D06842g 1 568031 569749 ON 4 D06842 (568031..569749) similar to gnl|GLV|KLLA0F01529g Kluyveromyces lactis KLLA0F01529g and some similarites with YBR270C uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF SAKL0D06864g 0 569845 571101 ON 4 D06864 complement(569845..571101) similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein SAKL0D06886g 0 571478 572821 ON 4 D06886 complement(571478..572821) highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway potential Cdc28p substrate SAKL0D06908g 1 573206 573601 ON 4 D06908 (573206..573601) similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria SAKL0D06930g 0 573700 575772 ON 4 D06930 complement(573700..575772) similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC SAKL0D06952g 0 576023 576346 ON 4 D06952 complement(576023..576346) similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit SAKL0D06974g 0 576570 579011 ON 4 D06974 complement(576570..579011) similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity SAKL0D06996g 0 579219 580415 ON 4 D06996 complement(579219..580415) similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains SAKL0D07018g 0 580687 581637 ON 4 D07018 complement(580687..581637) similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase SAKL0D07040g 0 581860 582129 ON 4 D07040 complement(581860..582129) similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF SAKL0D07062g 1 582391 583116 ON 4 D07062 (582391..583116) similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit SAKL0D07084g 1 583675 584754 ON 4 D07084 (583675..584754) similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF SAKL0D07106g 0 584930 587293 ON 4 D07106 complement(584930..587293) similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle SAKL0D07128g 1 587676 588221 ON 4 D07128 (587676..588221) similar to uniprot|Q758B1 Ashbya gossypii AEL159W AEL159Wp and some similarites with YBR278W uniprot|P27344 Saccharomyces cerevisiae YBR278W DPB3 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing mRNA abundance peaks at the G1/S boundary of the cell cycle SAKL0D07150g 1 588572 589576 ON 4 D07150 (588572..589576) some similarities with uniprot|Q758B0 Ashbya gossypii AEL158W AEL158Wp and some similarities to YJL066C uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches SAKL0D07172g 1 589920 591101 ON 4 D07172 (589920..591101) similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes SAKL0D07194g 1 591271 592164 ON 4 D07194 (591271..592164) similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF SAKL0D07216g 0 592212 594038 ON 4 D07216 complement(592212..594038) similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF SAKL0D07238g 0 594187 596784 ON 4 D07238 complement(594187..596784) similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF SAKL0D07260g 1 597979 599709 ON 4 D07260 (597979..599709) similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data SAKL0D07282g 1 599899 600336 ON 4 D07282 (599899..600336) highly similar to gnl|GLV|CAGL0B03267g Candida glabrata CAGL0B03267g and similar to YBR282W uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit SAKL0D07304g 0 600969 602505 ON 4 D07304 complement(600969..602431,602496..602505) highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential SAKL0D07326g 1 602669 602962 ON 4 D07326 (602669..602962) conserved hypothetical protein SAKL0D07348g 1 603224 603925 ON 4 D07348 (603224..603925) highly similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0D07392g 1 604396 605325 ON 4 D07392 (604396..605325) no similarity SAKL0D07414g 1 607252 609372 ON 4 D07414 (607252..609372) similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization SAKL0D07436g 0 609760 611973 ON 4 D07436 complement(609760..611973) some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition SAKL0D07458g 0 612471 614822 ON 4 D07458 complement(612471..614822) some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition SAKL0D07480g 0 615534 617513 ON 4 D07480 complement(615534..617513) some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition SAKL0D07502g 1 617634 618005 ON 4 D07502 (617634..618005) similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres SAKL0D07524g 0 618008 618835 ON 4 D07524 complement(618008..618835) similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P SAKL0D07546g 1 619015 620265 ON 4 D07546 (619015..620265) similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF SAKL0D07568g 0 620394 622535 ON 4 D07568 complement(620394..622535) similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes SAKL0D07590g 1 622837 623760 ON 4 D07590 (622837..623760) conserved hypothetical protein SAKL0D07612g 1 624385 626778 ON 4 D07612 (624385..626778) similar to uniprot|Q752H8 Ashbya gossypii AFR606C AFR606Cp and weakly similar to YFR013W uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing Sklu_4.trna23M 0 626996 627068 ON 4 tM-CAU complement(626996..627068) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 SAKL0D07656g 0 627469 628767 ON 4 D07656 complement(627469..628767) similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1 SAKL0D07678g 0 629558 631678 ON 4 D07678 complement(629558..631678) highly similar to uniprot|P27472 Saccharomyces cerevisiae or YFR015C uniprot|P23337 Saccharomyces cerevisiae SAKL0D07700g 0 632735 634786 ON 4 D07700 complement(632735..634786) conserved hypothetical protein SAKL0D07722g 0 641356 643014 ON 4 D07722 complement(641356..643014) some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF SAKL0D07744g 0 642977 643873 ON 4 D07744 complement(642977..643873) similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF Sklu_4.trna24G 0 644631 644701 ON 4 tG-GCC complement(644631..644701) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0D07810g 1 646022 647623 ON 4 D07810 (646022..647623) similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF SAKL0D07832g 1 648198 649076 ON 4 D07832 (648198..649076) conserved hypothetical protein SAKL0D07854g 0 649616 651382 ON 4 D07854 complement(649616..651382) weakly similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation Sklu_4.trna25D 0 651912 651983 ON 4 tD-GUC complement(651912..651983) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0D07898g 0 653332 657066 ON 4 D07898 complement(653332..657066) similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 SAKL0D07920g 1 659019 659546 ON 4 D07920 (659019..659546) similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 homolog of nuclear distribution factor NudE NUDEL SAKL0D07942g 0 659606 661291 ON 4 D07942 complement(659606..661291) similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF SAKL0D07964g 0 662567 663169 ON 4 D07964 complement(662567..663169) highly similar to gnl|GLV|KLLA0F22924g Kluyveromyces lactis KLLA0F22924g and similar to YLR251W uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17 required for ethanol metabolismand induced by heat shock localized to the inner mitochondrial membrane SAKL0D07986g 1 663489 665255 ON 4 D07986 (663489..665255) similar to uniprot|Q754E9 Ashbya gossypii AFR121W AFR121Wp and some similarites with YKR015C uniprot|P36111 Saccharomyces cerevisiae YKR015C Hypothetical ORF SAKL0D08008g 0 665498 669184 ON 4 D08008 complement(665498..669184) similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 SAKL0D08030g 0 670268 672118 ON 4 D08030 complement(670268..672118) similar to gnl|GLV|KLLA0F22858g Kluyveromyces lactis KLLA0F22858g and weakly similar to YLR173W uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF SAKL0D08052g 1 672963 673508 ON 4 D08052 (672963..673508) some similarities with uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF SAKL0D08074g 0 673663 674133 ON 4 D08074 complement(673663..674133) highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin- associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex SAKL0D08096g 0 674709 675611 ON 4 D08096 complement(674709..675611) highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm Sklu_4.trna26H 1 676353 676424 ON 4 tH-GUG (676353..676424) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 Sklu_4.trna27V 1 676434 676507 ON 4 tV-AAC (676434..676507) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0D08162g 1 677089 678333 ON 4 D08162 (677089..678333) similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1 SAKL0D08217g1 1 679723 681045 ON 4 D08217 (679723..681045) Retrotransposon Gag gene Sklu_4.trna28L 1 685609 685731 ON 4 tL-CAA (685609..685646,685688..685731) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 53.36 SAKL0D08272g 0 687452 691927 ON 4 D08272 complement(687452..691927) similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF SAKL0D08294g 1 692455 693966 ON 4 D08294 (692455..693966) some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations SAKL0D08316g 1 695101 698235 ON 4 D08316 (695101..698235) highly similar to uniprot|P16521 Saccharomyces cerevisiae YLR249W YEF3 stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex contains two ABC cassettes and binds and hydrolyses ATP EF-3 (translational elongation factor 3) SAKL0D08338g 1 699479 701233 ON 4 D08338 (699479..701233) similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W SAKL0D08360g 1 701415 702113 ON 4 D08360 (701415..702113) similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D08382g 0 702147 703466 ON 4 D08382 complement(702147..703466) similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF SAKL0D08404g 1 703792 704505 ON 4 D08404 (703792..704505) highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF SAKL0D08426g 1 705189 706424 ON 4 D08426 (705189..706424) highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha- ketoglutarate levels are elevated during growth on non- fermentable carbon sources and reduced during growth on glucose Sklu_4.trna29G 1 707681 707751 ON 4 tG-GCC (707681..707751) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0D08492g 1 708312 709208 ON 4 D08492 (708312..709208) highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria SAKL0D08514g 0 709458 710600 ON 4 D08514 complement(709458..710600) similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit SAKL0D08536g 1 710822 711565 ON 4 D08536 (710822..711565) similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex SAKL0D08558g 1 712000 713394 ON 4 D08558 (712000..713394) similar to uniprot|P38922 Saccharomyces cerevisiae YNL004W SAKL0D08580g 1 713577 714083 ON 4 D08580 (713577..713697,713767..714083) similar to uniprot|Q8J0M4 Saccharomyces cerevisiae YCL012C SAKL0D08602g 0 714170 719065 ON 4 D08602 complement(714170..719065) similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding SAKL0D08624g 1 719181 720305 ON 4 D08624 (719181..720305) similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion SAKL0D08646g 0 720371 721198 ON 4 D08646 complement(720371..721198) similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth SAKL0D08668g 1 721456 722937 ON 4 D08668 (721456..722937) highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post- transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria SAKL0D08690g 0 723302 724396 ON 4 D08690 complement(723302..724396) highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway SAKL0D08712g 0 724741 725679 ON 4 D08712 complement(724741..725679) similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C SAKL0D08734g 1 726095 728581 ON 4 D08734 (726095..728581) weakly similar to uniprot|P48743 Saccharomyces cerevisiae YLR176C SAKL0D08756g 0 728765 729676 ON 4 D08756 complement(728765..729676) highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat SAKL0D08778g 1 729953 730999 ON 4 D08778 (729953..730999) similar to uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog SAKL0D08800g 0 732221 733960 ON 4 D08800 complement(732221..733960) conserved hypothetical protein SAKL0D08822g 0 734328 734879 ON 4 D08822 complement(734328..734879) similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit SAKL0D08844g 1 735165 736163 ON 4 D08844 (735165..736163) highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM Sklu_CEN4 1 737092 737289 ON 4 CEN4 (737092..737289) Chromosome IV centromere SAKL0D08888g 0 737574 738740 ON 4 D08888 complement(737574..738740) similar to uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA-binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division SAKL0D08910g 0 739182 739733 ON 4 D08910 complement(739182..739733) highly similar to uniprot|Q75ET0 Ashbya gossypii AAL002W AAL002Wp and similar to YCL001W uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER SAKL0D08932g 1 740276 741135 ON 4 D08932 (740276..740320,740392..741135) similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C Hypothetical ORF SAKL0D08954g 0 741228 742781 ON 4 D08954 complement(741228..742781) similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Sklu_4.trna30R 1 742967 743038 ON 4 tR-UCU (742967..743038) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0D08998g 0 743706 744596 ON 4 D08998 complement(743706..744596) weakly similar to uniprot|P25587 Saccharomyces cerevisiae YCL005W Hypothetical ORF SAKL0D09020g 0 745470 745886 ON 4 D09020 complement(745470..745886) no similarity Sklu_4.trna31D 1 747473 747544 ON 4 tD-GUC (747473..747544) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 Sklu_YGOB_VMA9 0 748119 748512 ON 4 VMA9 complement(748119..748248,748344..748424,748505..748512) ANNOTATED BY YGOB - SAKL0D09086g 1 748676 750117 ON 4 D09086 (748676..748735,748807..750117) similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype SAKL0D09108g 1 750336 751793 ON 4 D09108 (750336..751793) similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs) probable rRNA pseudouridine synthase binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p SAKL0D09130g 0 758233 758985 ON 4 D09130 complement(758233..758985) similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D09152g 0 759717 761419 ON 4 D09152 complement(759717..760946,761154..761234,761303..761419) uniprot|Q9P4E3 Saccharomyces kluyveri Putative citrate synthase Sklu_4.trna32P 0 761924 761995 ON 4 tP-AGG complement(761924..761995) tRNA Type: Pro (P) | Anti-Codon: AGG | Cove Score: 66.45 Sklu_4.trna33N 1 763603 763676 ON 4 tN-GUU (763603..763676) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0D09240g 1 764130 765761 ON 4 D09240 (764130..765761) some similarities with uniprot|P25333 Saccharomyces cerevisiae YCR008W SAKL0D09262g 0 766195 769881 ON 4 D09262 complement(766195..769881) conserved hypothetical protein SAKL0D09284g 0 770533 771330 ON 4 D09284 complement(770533..771330) highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress SAKL0D09306g 1 771565 772545 ON 4 D09306 (771565..772545) similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C MHT1 S-methylmethionine-homocysteine methyltransferase SAKL0D09328g 0 772862 773725 ON 4 D09328 complement(772862..773725) similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads SAKL0D09350g 1 775699 778362 ON 4 D09350 (775699..778362) similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family with potential orthologs in S. pombe and C. albicans SAKL0D09372g 0 778946 779887 ON 4 D09372 complement(778946..779887) similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex SAKL0D09394g 0 780019 783102 ON 4 D09394 complement(780019..783102) highly similar to gnl|GLV|KLLA0D04554g Kluyveromyces lactis KLLA0D04554g and similar to YCR011C uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase SAKL0D09416g 0 783254 784222 ON 4 D09416 complement(783254..784222) weakly similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF SAKL0D09438g 1 784368 790895 ON 4 D09438 (784368..790895) weakly similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis Sklu_4.trna34S 0 791652 791754 ON 4 tS-GCU complement(791652..791696,791718..791754) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 60.97 SAKL0D09504g 1 792974 794599 ON 4 D09504 (792974..794599) highly similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5- bisphosphate-binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre- autophagosomal structure SAKL0D09526g 1 795027 797372 ON 4 D09526 (795027..797372) similar to uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase Sklu_4.trna35A 1 798510 798582 ON 4 tA-AGC (798510..798582) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 Sklu_4.trna36Q 1 799368 799439 ON 4 tQ-UUG (799368..799439) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D09658g 1 800114 802186 ON 4 D09658 (800114..802186) similar to uniprot|Q07500 Saccharomyces cerevisiae YDL085W NDE2 Mitochondrial external NADH dehydrogenase SAKL0D09680g 1 803363 805381 ON 4 D09680 (803363..805381) similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae SAKL0D09702g 0 805912 807372 ON 4 D09702 complement(805912..807151,807326..807372) similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84 SAKL0D09724g 1 807580 808644 ON 4 D09724 (807580..808644) similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W SAKL0D09746g 0 808721 810115 ON 4 D09746 complement(808721..810115) highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase catalyzes the final step in the arginine biosynthesis pathway SAKL0D09768g 0 811148 812830 ON 4 D09768 complement(811148..812830) highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA SAKL0D09790g 0 813893 814282 ON 4 D09790 complement(813893..814282) no similarity SAKL0D09812g 1 815252 817276 ON 4 D09812 (815252..817276) highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability SAKL0D09834g 0 817383 818384 ON 4 D09834 complement(817383..818384) similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control SAKL0D09856g 1 818550 819683 ON 4 D09856 (818550..819683) conserved hypothetical protein SAKL0D09878g 1 820412 822475 ON 4 D09878 (820412..822475) no similarity Sklu_4.trna37A 0 823294 823366 ON 4 tA-AGC complement(823294..823366) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0D09922g 1 827075 827836 ON 4 D09922 (827075..827836) conserved hypothetical protein SAKL0D09944g 1 828689 832747 ON 4 D09944 (828689..832747) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) SAKL0D09966g 1 834020 835027 ON 4 D09966 (834020..835027) similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p SAKL0D09988g 0 835350 836897 ON 4 D09988 complement(835350..836897) highly similar to gnl|GLV|KLLA0B06622g Kluyveromyces lactis KLLA0B06622g and similar to YFR028C uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit Sklu_4.trna38Y 0 837179 837278 ON 4 tY-GUA complement(837179..837214,837240..837278) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 72.06 SAKL0D10032g 1 840096 841229 ON 4 D10032 (840096..841229) similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs SAKL0D10054g 0 841835 843745 ON 4 D10054 complement(841835..843745) weakly similar to uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole Sklu_4.trna39Y 0 843922 844021 ON 4 tY-GUA complement(843922..843957,843983..844021) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 72.80 SAKL0D10098g 1 844371 844835 ON 4 D10098 (844371..844835) similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C Hypothetical ORF SAKL0D10120g 0 845029 846581 ON 4 D10120 complement(845029..846491,846566..846581) highly similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds SAKL0D10131g 0 846993 848705 ON 4 D10131 complement(846993..848705) similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily Sklu_YGOB_Anc_1.368 0 849414 851040 ON 4 Anc_1.368 complement(849414..850103,850105..851040) ANNOTATED BY YGOB - SAKL0D10164g 1 851604 852002 ON 4 D10164 (851604..852002) conserved hypothetical protein SAKL0D10186g 1 852303 855269 ON 4 D10186 (852303..855269) highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family SAKL0D10208g 0 855378 857636 ON 4 D10208 complement(855378..857636) highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA Sklu_4.trna40G 0 857754 857824 ON 4 tG-GCC complement(857754..857824) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0D10252g 1 857985 859262 ON 4 D10252 (857985..859262) similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability SAKL0D10274g 0 859344 861428 ON 4 D10274 complement(859344..861428) similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2 SAKL0D10296g 0 861567 862823 ON 4 D10296 complement(861567..862823) conserved hypothetical protein SAKL0D10318g 0 863185 863805 ON 4 D10318 complement(863185..863805) similar to uniprot|P43598 Saccharomyces cerevisiae YFR017C Hypothetical ORF SAKL0D10340g 0 864287 866431 ON 4 D10340 complement(864287..866431) some similarities with uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 affects longevity involved in determination of longevity SAKL0D10362g 1 866957 867352 ON 4 D10362 (866957..867352) no similarity SAKL0D10384g 1 867394 868644 ON 4 D10384 (867394..868644) highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis SAKL0D10406g 0 870588 871499 ON 4 D10406 complement(870588..871499) similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Hypothetical ORF SAKL0D10428g 1 872379 873176 ON 4 D10428 (872379..873176) similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Hypothetical ORF SAKL0D10450g 1 875475 877151 ON 4 D10450 (875475..877151) highly similar to gnl|GLV|KLLA0A11110g Kluyveromyces lactis KLLA0A11110g SAKL0D10472g 1 878248 879255 ON 4 D10472 (878248..879255) some similarities with uniprot|P40342 Saccharomyces cerevisiae YNR004W Hypothetical ORF SAKL0D10494g 0 879560 882601 ON 4 D10494 complement(879560..882601) similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion Sklu_4.trna41K 1 882857 882929 ON 4 tK-CUU (882857..882929) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0D10538g 0 883107 885224 ON 4 D10538 complement(883107..885224) highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)- fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D10560g 0 885746 886369 ON 4 D10560 complement(885746..886369) highly similar to gnl|GLV|KLLA0A11198g Kluyveromyces lactis KLLA0A11198g and similar to YEL012W uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin- conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1 6-bisphosphatase (FBPase) cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro Sklu_YGOB_Anc_1.437 0 886967 887182 ON 4 Anc_1.437 complement(886967..887182) ANNOTATED BY YGOB - SAKL0D10582g 1 887393 887689 ON 4 D10582 (887393..887689) similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus member of the Sm protein family SAKL0D10604g 1 887885 888538 ON 4 D10604 (887885..888538) similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome SAKL0D10626g 0 888612 889667 ON 4 D10626 complement(888612..889667) similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles Sklu_4.trna42M 1 890705 890776 ON 4 tM-CAU (890705..890776) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.91 Sklu_4.trna43Q 1 891658 891729 ON 4 tQ-UUG (891658..891729) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D10736g 0 892250 893944 ON 4 D10736 complement(892250..893944) highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions SAKL0D10758g 0 894565 896106 ON 4 D10758 complement(894565..896106) similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies SAKL0D10780g 1 896563 897222 ON 4 D10780 (896563..897222) similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake member of the Ras superfamily of G-proteins SAKL0D10802g 0 897392 898330 ON 4 D10802 complement(897392..898330) conserved hypothetical protein SAKL0D10824g 1 899660 901309 ON 4 D10824 (899660..901309) some similarities with uniprot|P25353 Saccharomyces cerevisiae YCR026C NPP1 Hypothetical ORF and to YEL016C uniprot|P39997 Saccharomyces cerevisiae YEL016C NPP2 Hypothetical ORF SAKL0D10846g 0 901439 902449 ON 4 D10846 complement(901439..902449) some similarities with uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism as suggested by computational analysis of large-scale protein-protein interaction data GFP-fusion protein localizes to the nuclear periphery Sklu_YGOB_PMP1 1 902877 903161 ON 4 PMP1 (902877..903161) ANNOTATED BY YGOB - SAKL0D10868g 0 903764 904450 ON 4 D10868 complement(903764..904450) weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex SAKL0D10890g 1 904673 905470 ON 4 D10890 (904673..905470) similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination SAKL0D10912g 1 906020 907468 ON 4 D10912 (906020..907468) similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase SAKL0D10934g 1 907649 909301 ON 4 D10934 (907649..909301) similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical ORF SAKL0D11000g 1 910457 912430 ON 4 D11000 (910457..912430) similar to uniprot|P25351 Saccharomyces cerevisiae YCR023C Hypothetical ORF SAKL0D11022g 0 912910 913173 ON 4 D11022 complement(912910..913173) highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins SAKL0D11044g 0 913457 914260 ON 4 D11044 complement(913457..914260) highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase SAKL0D11066g 1 914685 916094 ON 4 D11066 (914685..916094) conserved hypothetical protein SAKL0D11088g 0 916181 920452 ON 4 D11088 complement(916181..920452) similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W SAKL0D11110g 1 920630 921928 ON 4 D11110 (920630..921928) similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity SAKL0D11132g 0 922076 926215 ON 4 D11132 complement(922076..926215) similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate SAKL0D11154g 1 926677 927003 ON 4 D11154 (926677..927003) similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase Sklu_4.trna44P 1 928009 928112 ON 4 tP-UGG (928009..928044,928077..928112) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.25 SAKL0D11198g 1 928230 931388 ON 4 D11198 (928230..931388) similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein SAKL0D11220g 1 931648 933747 ON 4 D11220 (931648..933747) similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF SAKL0D11242g 0 934163 934807 ON 4 D11242 complement(934163..934807) highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex SAKL0D11264g 0 935124 937679 ON 4 D11264 complement(935124..937679) similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability SAKL0D11286g 1 938289 941777 ON 4 D11286 (938289..941777) some similarities with uniprot|P47107 Saccharomyces cerevisiae YJR039W Hypothetical ORF SAKL0D11308g 1 942247 945552 ON 4 D11308 (942247..945552) conserved hypothetical protein SAKL0D11330g 0 945638 946021 ON 4 D11330 complement(945638..946021) highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri- snRNP involved in mRNA splicing, similar to human 15.5K protein SAKL0D11352g 1 947308 949659 ON 4 D11352 (947308..949659) similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post- Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates SAKL0D11374g 0 949748 953212 ON 4 D11374 complement(949748..953212) similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis SAKL0D11396g 1 953470 955686 ON 4 D11396 (953470..955686) similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking SAKL0D11418g 0 955977 956459 ON 4 D11418 complement(955977..956459) similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis SAKL0D11440g 0 956726 957862 ON 4 D11440 complement(956726..957862) similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error- prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p Sklu_4.trna45M 0 958186 958257 ON 4 tM-CAU complement(958186..958257) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.91 SAKL0D11484g 0 958582 959460 ON 4 D11484 complement(958582..959460) conserved hypothetical protein SAKL0D11506g 1 959925 960860 ON 4 D11506 (959925..960860) similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C SAKL0D11528g 0 960867 962018 ON 4 D11528 complement(960867..962018) weakly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate Sklu_4.trna46Q 1 963027 963098 ON 4 tQ-UUG (963027..963098) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0D11616g 0 963250 964023 ON 4 D11616 complement(963250..963551,963903..964023) similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Vacuolar Protein Sorting YJR044c SAKL0D11638g 0 964598 966592 ON 4 D11638 complement(964598..966592) highly similar to uniprot|P12398 Saccharomyces cerevisiae YJR045C SAKL0D11660g 1 966929 968620 ON 4 D11660 (966929..968620) similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication) SAKL0D11682g 0 968688 972314 ON 4 D11682 complement(968688..972314) highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase SAKL0D11704g 0 972803 975667 ON 4 D11704 complement(972803..975667) similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Sklu_4.trna47S 0 976355 976462 ON 4 tS-AGA complement(976355..976399,976426..976462) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 70.49 SAKL0D11748g 0 976588 977739 ON 4 D11748 complement(976588..977739) conserved hypothetical protein SAKL0D11770g 0 978602 979075 ON 4 D11770 complement(978602..979075) highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A SAKL0D11792g 1 979538 980989 ON 4 D11792 (979538..980989) similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex SAKL0D11814g 1 981832 983034 ON 4 D11814 (981832..983034) similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23 SAKL0D11836g 0 983118 983804 ON 4 D11836 complement(983118..983804) similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus SAKL0D11858g 1 984317 984649 ON 4 D11858 (984317..984649) highly similar to uniprot|P00044 Saccharomyces cerevisiae CYC1 Cytochrome c isoform 1 and to YEL039C uniprot|P00045 Saccharomyces cerevisiae CYC7 Cytochrome c isoform 2 SAKL0D11880g 0 985100 986551 ON 4 D11880 complement(985100..986551) similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance SAKL0D11902g 0 986913 988586 ON 4 D11902 complement(986913..988586) highly similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p) SAKL0D11924g 0 989146 990780 ON 4 D11924 complement(989146..990780) similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate SAKL0D11946g 0 991104 992756 ON 4 D11946 complement(991104..992756) similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 SAKL0D11968g 1 993844 994650 ON 4 D11968 (993844..994650) similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest SAKL0D11990g 0 994808 997408 ON 4 D11990 complement(994808..997408) weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W Hypothetical ORF SAKL0D12012g 0 998417 998929 ON 4 D12012 complement(998417..998929) similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions SAKL0D12034g 1 999427 1000587 ON 4 D12034 (999427..1000587) highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis SAKL0D12056g 1 1001687 1003168 ON 4 D12056 (1001687..1003168) similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C Fumurate ReDuctase Soluble Sklu_4.trna48G 1 1003747 1003817 ON 4 tG-CCC (1003747..1003817) tRNA Type: Gly (G) | Anti-Codon: CCC | Cove Score: 65.85 SAKL0D12100g 1 1004099 1005739 ON 4 D12100 (1004099..1005739) some similarities with uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF SAKL0D12122g 0 1005921 1006364 ON 4 D12122 complement(1005921..1006364) similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF Sklu_4.trna49G 1 1007218 1007288 ON 4 tG-GCC (1007218..1007288) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0D12188g 1 1007392 1009086 ON 4 D12188 (1007392..1009086) similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) SAKL0D12210g 0 1009364 1011313 ON 4 D12210 complement(1009364..1011313) similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats SAKL0D12232g 1 1011546 1013348 ON 4 D12232 (1011546..1013348) similar to gnl|GLV|KLLA0A08041g Kluyveromyces lactis KLLA0A08041g and weakly similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis SAKL0D12254g 0 1013532 1017065 ON 4 D12254 complement(1013532..1017065) weakly similar to gnl|GLV|DEHA0F10505g Debaryomyces hansenii DEHA0F10505g SAKL0D12276g 0 1019727 1021406 ON 4 D12276 complement(1019727..1021406) some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate Sklu_4.trna50R 1 1022002 1022073 ON 4 tR-CCU (1022002..1022073) tRNA Type: Arg (R) | Anti-Codon: CCU | Cove Score: 71.23 Sklu_YGOB_Kwal_27.10058 1 1022855 1023028 ON 4 Kwal_27.10058 (1022855..1023028) ANNOTATED BY YGOB - SAKL0D12320g 0 1023219 1024367 ON 4 D12320 complement(1023219..1024367) similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression SAKL0D12342g 1 1025386 1029390 ON 4 D12342 (1025386..1029390) similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing SAKL0D12364g 0 1029504 1030529 ON 4 D12364 complement(1029504..1030529) similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W Hypothetical ORF SAKL0D12386g 1 1030805 1031284 ON 4 D12386 (1030805..1031284) similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature Sklu_YGOB_Anc_1.500 0 1031448 1032158 OFF 4 Anc_1.500 complement(1031448..1032158) ANNOTATED BY YGOB - Sklu_YGOB_Anc_1.500b 0 1031448 1032728 ON 4 Anc_1.500b complement(1031448..1032275,1032279..1032728) ANNOTATED BY YGOB - SAKL0D12430g 0 1033664 1034548 ON 4 D12430 complement(1033664..1034548) similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Multicopy suppressor of rvs167 mutation putative integral membrane protein SAKL0D12452g 0 1035331 1035843 ON 4 D12452 complement(1035331..1035843) weakly similar to uniprot|P47115 Saccharomyces cerevisiae YJR056C Hypothetical ORF SAKL0D12474g 1 1036027 1036599 ON 4 D12474 (1036027..1036599) conserved hypothetical protein SAKL0D12496g 1 1038594 1039571 ON 4 D12496 (1038594..1039571) conserved hypothetical protein similar to S. cerevisiae YNL144C Sklu_4.trna51Y 0 1039803 1039902 ON 4 tY-GUA complement(1039803..1039838,1039864..1039902) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 67.12 SAKL0D12562g 1 1042085 1042729 ON 4 D12562 (1042085..1042729) similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p SAKL0D12584g 0 1042763 1043239 ON 4 D12584 complement(1042763..1043239) highly similar to gnl|GLV|CAGL0H01859g Candida glabrata CAGL0H01859g and similar to YJR058C uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin- associated protein (AP-2) complex SAKL0D12606g 1 1044200 1047274 ON 4 D12606 (1044200..1047274) similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP- binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes SAKL0D12628g 1 1048973 1051429 ON 4 D12628 (1048973..1051429) weakly similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake SAKL0D12650g 1 1052104 1052814 ON 4 D12650 (1052104..1052814) some similarities with uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Helix-loop-helix protein that binds the motif CACRTG (R SAKL0D12672g 1 1053514 1056327 ON 4 D12672 (1053514..1056327) weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p) involved in mannosylphosphorylation of N-linked oligosaccharides expression increases in late-logarithmic and stationary growth phases SAKL0D12694g 0 1056445 1057686 ON 4 D12694 complement(1056445..1057686) similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N- terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation SAKL0D12716g 0 1058482 1061454 ON 4 D12716 complement(1058482..1061454) similar to gnl|GLV|KLLA0B13838g Kluyveromyces lactis KLLA0B13838g gi|28565042|gb|AAO32604.1 Kluyveromyces lactis YJR061W hypothetical start KLLA0B13838g|KLLA-IPF6935|KLLA-CDS0443.1 and weakly similar to YJR061W uniprot|P40355 Saccharomyces cerevisiae YJR061W Hypothetical ORF SAKL0D12738g 1 1062014 1062412 ON 4 D12738 (1062014..1062412) conserved hypothetical protein SAKL0D12760g 1 1063148 1063525 ON 4 D12760 (1063148..1063525) highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex SAKL0D12782g 1 1063966 1065648 ON 4 D12782 (1063966..1065648) highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo SAKL0D12804g 0 1066058 1067428 ON 4 D12804 complement(1066058..1067428) highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity SAKL0D12826g 1 1068114 1075520 ON 4 D12826 (1068114..1075520) highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg SAKL0D12848g 0 1075555 1076016 ON 4 D12848 complement(1075555..1076016) similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function SAKL0D12870g 1 1076258 1077310 ON 4 D12870 (1076258..1077310) highly similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon SAKL0D12892g 0 1077415 1079241 ON 4 D12892 complement(1077415..1079241) weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein binds eIF4E and inhibits cap-dependent translation also functions independently of eIF4E to maintain genetic stability plays a role in cell growth implicated in the TOR signaling cascade SAKL0D12914g 0 1080337 1083492 ON 4 D12914 complement(1080337..1083492) highly similar to uniprot|Q753A0 Ashbya gossypii AFR424C AFR424Cp and similar to YKL205W uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA SAKL0D12936g 0 1084310 1084891 ON 4 D12936 complement(1084310..1084891) similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N- hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis SAKL0D12958g 0 1085467 1086435 ON 4 D12958 complement(1085467..1086435) highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C- terminal domain of Hyp2p (eIF5A) has four to five HEAT- like repeats SAKL0D12980g 1 1087088 1088002 ON 4 D12980 (1087088..1088002) similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C Hypothetical ORF SAKL0D13002g 0 1088057 1089217 ON 4 D13002 complement(1088057..1089217) highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre- ribosomal particles SAKL0D13024g 0 1089460 1090266 ON 4 D13024 complement(1089460..1090266) similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W Hypothetical ORF SAKL0D13046g 1 1091666 1092475 ON 4 D13046 (1091666..1092475) similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C SAKL0D13068g 0 1092845 1093177 ON 4 D13068 complement(1092845..1093177) similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF SAKL0D13090g 1 1093315 1094814 ON 4 D13090 (1093315..1094814) weakly similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins SAKL0D13112g 0 1094851 1095897 ON 4 D13112 complement(1094851..1095897) similar to uniprot|P47181 Saccharomyces cerevisiae YJR154W Hypothetical ORF SAKL0D13134g 0 1096222 1097580 ON 4 D13134 complement(1096222..1097580) conserved hypothetical protein SAKL0D13156g 1 1097801 1098925 ON 4 D13156 (1097801..1098925) similar to uniprot|Q75DH7 Ashbya gossypii ABR048W ABR048Wp and some similarites with YHL020C uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes SAKL0D13178g 0 1098968 1099639 ON 4 D13178 complement(1098968..1099639) highly similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion Sklu_4.trna52E 1 1099900 1099971 ON 4 tE-UUC (1099900..1099971) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0D13222g 1 1100206 1103931 ON 4 D13222 (1100206..1103931) similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W SAKL0D13244g 0 1104086 1105588 ON 4 D13244 complement(1104086..1105588) similar to uniprot|Q75DH5 Ashbya gossypii ABR051C and weakly similar to YMR013C uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol-P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation SAKL0D13376g 1 1107715 1109154 ON 4 D13376 (1107715..1109154) similar to gnl|GLV|CAGL0M07678g Candida glabrata CAGL0M07678g and weakly similar to YMR014W uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0D13398g 0 1109404 1111026 ON 4 D13398 complement(1109404..1111026) highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs SAKL0D13420g 0 1111479 1112474 ON 4 D13420 complement(1111479..1112474) similar to uniprot|Q75DH2 Ashbya gossypii ABR054C ABR054Cp and weakly similar to YKL042W uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB) involved in SPB duplication may facilitate attachment of the SPB to the nuclear membrane SAKL0D13442g 0 1113205 1115568 ON 4 D13442 complement(1113205..1115568) some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors SAKL0D13464g 1 1116277 1118340 ON 4 D13464 (1116277..1118340) weakly similar to uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two- hybrid assay SAKL0D13486g 0 1118487 1120001 ON 4 D13486 complement(1118487..1120001) highly similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair SAKL0D13508g 1 1120316 1121809 ON 4 D13508 (1120316..1121809) similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis SAKL0D13530g 0 1121969 1123117 ON 4 D13530 complement(1121969..1123117) similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport SAKL0D13552g 1 1123716 1124213 ON 4 D13552 (1123716..1124213) highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly SAKL0D13574g 1 1125011 1126366 ON 4 D13574 (1125011..1126366) highly similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p SAKL0D13596g 0 1126435 1127994 ON 4 D13596 complement(1126435..1127994) similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF Sklu_YGOB_Anc_2.572 1 1128088 1128438 ON 4 Anc_2.572 (1128088..1128438) ANNOTATED BY YGOB - SAKL0D13618g 0 1128458 1129948 ON 4 D13618 complement(1128458..1129948) similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C Sklu_4.trna53A 0 1130050 1130122 ON 4 tA-AGC complement(1130050..1130122) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0D13662g 1 1130355 1131401 ON 4 D13662 (1130355..1131401) conserved hypothetical protein SAKL0D13684g 1 1131836 1132990 ON 4 D13684 (1131836..1132990) highly similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit SAKL0D13706g 1 1133253 1134008 ON 4 D13706 (1133253..1134008) conserved hypothetical protein SAKL0D13728g 0 1134048 1135229 ON 4 D13728 complement(1134048..1135229) similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p SAKL0D13750g 0 1135597 1135962 ON 4 D13750 complement(1135597..1135962) no similarity SAKL0D13772g 0 1136560 1136904 ON 4 D13772 complement(1136560..1136904) no similarity SAKL0D13794g 0 1137658 1138743 ON 4 D13794 complement(1137658..1138743) highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis SAKL0D13816g 0 1139692 1140237 ON 4 D13816 complement(1139692..1140237) conserved hypothetical protein SAKL0D13838g 1 1140347 1140835 ON 4 D13838 (1140347..1140835) no similarity SAKL0D13860g 1 1140924 1142300 ON 4 D13860 (1140924..1142300) similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition SAKL0D13882g 0 1142470 1143753 ON 4 D13882 complement(1142470..1143753) similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA- binding zinc knuckle motif SAKL0D13904g 1 1143953 1144300 ON 4 D13904 (1143953..1144300) highly similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain SAKL0D13926g 1 1144687 1145790 ON 4 D13926 (1144687..1145790) similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits SAKL0D13948g 0 1145866 1148943 ON 4 D13948 complement(1145866..1148943) similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p SAKL0D13970g 0 1149318 1151045 ON 4 D13970 complement(1149318..1151045) similar to gnl|GLV|KLLA0C12749g Kluyveromyces lactis KLLA0C12749g and weakly similar to YMR029C uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p SAKL0D13992g 0 1151305 1151808 ON 4 D13992 complement(1151305..1151808) highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF SAKL0D14014g 0 1151960 1152865 ON 4 D14014 complement(1151960..1152865) similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier- protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p SAKL0D14036g 0 1153177 1155333 ON 4 D14036 complement(1153177..1155333) some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII SAKL0D14058g 0 1155750 1156004 ON 4 D14058 complement(1155750..1156004) highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology Similar to human sequence predicted by GENSCAN SAKL0D14080g 0 1156175 1157056 ON 4 D14080 complement(1156175..1157056) similar to gnl|GLV|KLLA0C12617g Kluyveromyces lactis KLLA0C12617g and weakly similar to YKL052C uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin- dependent kinases SAKL0D14102g 1 1157649 1158608 ON 4 D14102 (1157649..1158608) similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W SAKL0D14124g 1 1161815 1163077 ON 4 D14124 (1161815..1163077) similar to gnl|GLV|KLLA0C13057g Kluyveromyces lactis KLLA0C13057g and some similarites with YAL040C uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin Sklu_YGOB_Anc_7.35 1 1163832 1165151 ON 4 Anc_7.35 (1163832..1165151) ANNOTATED BY YGOB - SAKL0D14168g 1 1166936 1168330 ON 4 D14168 (1166936..1168330) similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source SAKL0D14190g 1 1168888 1170849 ON 4 D14190 (1168888..1170849) highly similar to uniprot|Q758Z0 Ashbya gossypii ADR387W ADR387Wp and similar to YOR356W uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF SAKL0D14212g 0 1171091 1173379 ON 4 D14212 complement(1171091..1173379) similar to uniprot|Q9HF59 Ashbya gossypii ADR388C CDC24 Cdc24 and some similarites with YAL041W uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing SAKL0D14234g 0 1173584 1174828 ON 4 D14234 complement(1173584..1174828) similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport SAKL0D14256g 0 1175017 1175508 ON 4 D14256 complement(1175017..1175508) similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C SAKL0D14278g 1 1175612 1176106 ON 4 D14278 (1175612..1176106) highly similar to uniprot|Q758Y6 Ashbya gossypii ADR391W ADR391Wp and similar to with YOR358W uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme- activated glucose-repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex SAKL0D14300g 1 1176205 1178451 ON 4 D14300 (1176205..1178451) similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII SAKL0D14322g 1 1178821 1180011 ON 4 D14322 (1178821..1180011) some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1 SAKL0D14344g 0 1180253 1181731 ON 4 D14344 complement(1180253..1181731) similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon SAKL0D14366g 1 1182056 1182559 ON 4 D14366 (1182056..1182559) highly similar to gnl|GLV|KLLA0A03597g Kluyveromyces lactis KLLA0A03597g and similar to YAL044C uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene- THF expression is regulated by levels of levels of 5 10- methylene-THF in the cytoplasm SAKL0D14388g 0 1183138 1183488 ON 4 D14388 complement(1183138..1183488) similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein SAKL0D14410g 1 1183649 1183933 ON 4 D14410 (1183649..1183933) highly similar to gnl|GLV|KLLA0A03553g Kluyveromyces lactis KLLA0A03553g and similar to YAL046C uniprot|P39724 Saccharomyces cerevisiae YAL046C Hypothetical ORF SAKL0D14432g 0 1184143 1186353 ON 4 D14432 complement(1184143..1186353) similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes SAKL0D14454g 1 1186923 1189358 ON 4 D14454 (1186923..1189358) weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization SAKL0D14476g 0 1189461 1190369 ON 4 D14476 complement(1189461..1190303,1190367..1190369) similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit SAKL0D14498g 1 1190537 1192623 ON 4 D14498 (1190537..1190579,1190642..1192623) highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail- anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death SAKL0D14520g 0 1192788 1195739 ON 4 D14520 complement(1192788..1195739) similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0D14542g 0 1195951 1198791 ON 4 D14542 complement(1195951..1198791) similar to gnl|GLV|KLLA0A03421g Kluyveromyces lactis KLLA0A03421g and weakly similar to YAL051W uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate- activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta- oxidation of fatty acids and peroxisome organization and biogenesis SAKL0D14564g 1 1200233 1200970 ON 4 D14564 (1200233..1200970) similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C Hypothetical ORF SAKL0D14586g 0 1201310 1203709 ON 4 D14586 complement(1201310..1203709) similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0D14608g 1 1204606 1206732 ON 4 D14608 (1204606..1206732) highly similar to uniprot|Q01574 Saccharomyces cerevisiae YAL054C ACS1 Acetyl-coA synthetase isoform expressed during growth on nonfermentable carbon sources and under aerobic conditions SAKL0D14630g 1 1206755 1207567 ON 4 D14630 (1206755..1207567) highly similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W SCP1 SAKL0D14652g 0 1207599 1208087 ON 4 D14652 complement(1207599..1208087) some similarities with uniprot|P39718 Saccharomyces cerevisiae YAL055W PEX22 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation SAKL0D14674g 1 1208192 1209388 ON 4 D14674 (1208192..1209388) similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins SAKL0D14696g 0 1209576 1210007 ON 4 D14696 complement(1209576..1210007) highly similar to uniprot|Q758W6 Ashbya gossypii ADR412C 40S ribosomal protein S12 and highly similar to YOR369C uniprot|P48589 Saccharomyces cerevisiae SAKL0D14718g 0 1210523 1212376 ON 4 D14718 complement(1210523..1212376) highly similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) SAKL0D14740g 0 1212855 1215377 ON 4 D14740 complement(1212855..1215377) similar to gnl|GLV|KLLA0F00374g Kluyveromyces lactis KLLA0F00374g and weakly similar to YOR371C uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p SAKL0D14762g 0 1215734 1217314 ON 4 D14762 complement(1215734..1217314) weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division SAKL0D14784g 1 1217440 1219836 ON 4 D14784 (1217440..1219836) some similarities with uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque, required for exit from mitosis SAKL0D14806g 1 1220261 1221817 ON 4 D14806 (1220261..1221817) highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed SAKL0D14828g 0 1222126 1223916 ON 4 D14828 complement(1222126..1223916) similar to uniprot|P27825 Saccharomyces cerevisiae YAL058W CNE1 Functions in endoplasmic reticulum protein quality control; Calnexin and calreticulin homolog SAKL0D14850g 0 1224313 1224849 ON 4 D14850 complement(1224313..1224849) similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export SAKL0D14872g 0 1226093 1227244 ON 4 D14872 complement(1226093..1227244) highly similar to gnl|GLV|KLLA0F00506g Kluyveromyces lactis KLLA0F00506g and similar to YAL060W uniprot|P39714 Saccharomyces cerevisiae YAL060W BDH1 NAD- dependent (2R 3R)-2 3-butanediol dehydrogenase a zinc- containing medium-chain alcohol dehydrogenase produces 2 3- butanediol from acetoin during fermentation and allows using 2 3-butanediol as a carbon source during aerobic growth SAKL0D14894g 0 1230497 1231654 ON 4 D14894 complement(1230497..1231654) similar to uniprot|P39713 Saccharomyces cerevisiae YAL061W putative polyol dehydrogenase SAKL0D14916g 0 1233415 1235313 ON 4 D14916 complement(1233415..1235313) conserved hypothetical protein SAKL0D14938g 0 1235542 1236678 ON 4 D14938 complement(1235542..1236678) similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance SAKL0D14960g 1 1237823 1239559 ON 4 D14960 (1237823..1239559) weakly similar to uniprot|P32465 Saccharomyces cerevisiae YHR094C HXT1 Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting SAKL0D14982g 0 1239814 1241199 ON 4 D14982 complement(1239814..1241199) highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesize glutamate from ammonia and alpha- ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources SAKL0D15026g 0 1243410 1244354 ON 4 D15026 complement(1243410..1244354) similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha- ketoglutarate dioxygenase SAKL0D15070g 0 1247653 1248276 ON 4 D15070 complement(1247653..1248276) similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W Hypothetical ORF SAKL0D15092g 0 1249248 1249997 ON 4 D15092 complement(1249248..1249997) similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH SAKL0D15114g 0 1251446 1253407 ON 4 D15114 complement(1251446..1253407) conserved hypothetical protein SAKL0D15136g 1 1255926 1256741 ON 4 D15136 (1255926..1256741) some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0D15158g 1 1257962 1259020 ON 4 D15158 (1257962..1259020) similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W SAKL0D15180g 0 1259592 1261325 ON 4 D15180 complement(1259592..1261325) similar to uniprot|P53059 Saccharomyces cerevisiae YGL257C MNT2 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans SAKL0D15202g 0 1264116 1264676 ON 4 D15202 complement(1264116..1264676) some similarities with gnl|GLV|DEHA0G07095g Debaryomyces hansenii DEHA0G07095g SAKL0D15224g 1 1264768 1265070 ON 4 D15224 (1264768..1265070) no similarity SAKL0D15268g 0 1269637 1270581 ON 4 D15268 complement(1269637..1270581) uniprot|Q7Z892 Saccharomyces kluyveri URA1 Dihydroorotate dehydrogenase SAKL0D15290g 1 1274588 1275202 ON 4 D15290 (1274588..1275202) some similarities with uniprot|P43542 Saccharomyces cerevisiae YFL062W COS4 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins SAKL0D15312g 1 1275517 1276116 ON 4 D15312 (1275517..1276116) some similarities with uniprot|P53344 Saccharomyces cerevisiae YGR295C COS6 Protein of unknown function member of a family of conserved often subtelomerically-encoded proteins SAKL0D15334g 1 1276249 1276524 ON 4 D15334 (1276249..1276524) no similarity SAKL0D15400g 1 1285935 1288109 ON 4 D15400 (1285935..1288109) some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments SAKL0D15422g 0 1288743 1289207 ON 4 D15422 complement(1288743..1289207) some similarities with uniprot|P43623 Saccharomyces cerevisiae YFR055W Hypothetical ORF SAKL0E00110g 1 71 1210 ON 5 E00110 (71..1210) some similarities with uniprot|Q9PFN1 Xylella fastidiosa XF_0626 Hypothetical protein SAKL0E00132g 1 3269 5131 ON 5 E00132 (3269..5131) similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C SAKL0E00154g 1 5710 5958 ON 5 E00154 (5710..5958) conserved hypothetical protein SAKL0E00176g 1 6272 6814 ON 5 E00176 (6272..6814) some similarities with uniprot|Q96W94 Saccharomyces kluyveri PYD3 Beta-alanine synthase SAKL0E00242g 0 9250 11406 ON 5 E00242 complement(9250..11406) some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments SAKL0E00264g 0 12234 13181 ON 5 E00264 complement(12234..13181) conserved hypothetical protein SAKL0E00286g 0 13788 14804 ON 5 E00286 complement(13788..14804) similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance SAKL0E00396g 0 20254 20493 ON 5 E00396 complement(20254..20493) no similarity SAKL0E00528g 0 30419 33406 ON 5 E00528 complement(30419..33406) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W SAKL0E00616g 0 37586 39394 ON 5 E00616 complement(37586..39394) similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p SAKL0E00638g 0 40747 41877 ON 5 E00638 complement(40747..41877) similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha- ketoglutarate dioxygenase SAKL0E00660g 0 42779 43747 ON 5 E00660 complement(42779..43747) highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'- terminal loop of 18 S rRNA part of 90S and 40S pre- particles in nucleolus involved in pre-ribosomal RNA processing SAKL0E00682g 0 43978 44637 ON 5 E00682 complement(43978..44637) similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1 Protein of unknown function potential Cdc28p substrate SAKL0E00704g 0 45027 47651 ON 5 E00704 complement(45027..47651) some similarities with uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide-specific phospholipase C hydrolyzes phosphatidylinositol 4 5- biphosphate (PIP2) to generate inositol 1 4 5-triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation SAKL0E00726g 0 47859 49580 ON 5 E00726 complement(47859..49580) similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small- budded cells through anaphase SAKL0E00748g 0 50683 53007 ON 5 E00748 complement(50683..53007) similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane Sklu_YGOB_Anc_6.6 0 53390 53575 ON 5 Anc_6.6 complement(53390..53575) ANNOTATED BY YGOB - SAKL0E00770g 1 53894 57037 ON 5 E00770 (53894..57037) similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C SAKL0E00792g 1 58155 59690 ON 5 E00792 (58155..59690) similar to uniprot|Q08984 Saccharomyces cerevisiae YPL272C Hypothetical ORF SAKL0E00814g 0 59724 60920 ON 5 E00814 complement(59724..60920) similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W SAKL0E00858g 1 63985 66528 ON 5 E00858 (63985..66528) conserved hypothetical protein SAKL0E00880g 0 66646 68556 ON 5 E00880 complement(66646..68556) similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function SAKL0E00902g 0 68682 70316 ON 5 E00902 complement(68682..70316) similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin SAKL0E00924g 1 70494 70787 ON 5 E00924 (70494..70787) similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A SOM1 Protein whose overexpression suppresses the imp1 mutation may be required for the function of the Imp1p mitochondrial inner membrane peptidase and/or the protein sorting machinery SAKL0E00946g 1 72220 73701 ON 5 E00946 (72220..73701) highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation Sklu_5.trna1L 0 74152 74274 ON 5 tL-CAA complement(74152..74195,74237..74274) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.24 SAKL0E01012g 1 75498 77132 ON 5 E01012 (75498..77132) similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation SAKL0E01034g 1 78600 79343 ON 5 E01034 (78600..79343) conserved hypothetical protein SAKL0E01056g 1 79518 80327 ON 5 E01056 (79518..80327) similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability SAKL0E01078g 1 80541 83387 ON 5 E01078 (80541..83387) similar to uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation SAKL0E01100g 0 83492 85624 ON 5 E01100 complement(83492..85624) similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences SAKL0E01144g 0 88424 89716 ON 5 E01144 complement(88424..89716) similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF Sklu_YGOB_Anc_6.20b 1 89924 93193 ON 5 Anc_6.20b (89924..92470,92474..93193) ANNOTATED BY YGOB - Sklu_YGOB_Anc_6.20 1 89924 92473 OFF 5 Anc_6.20 (89924..92473) ANNOTATED BY YGOB - SAKL0E01210g 0 93267 94238 ON 5 E01210 complement(93267..94238) similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans Sklu_5.trna2R 0 94683 94776 ON 5 tR-ACG complement(94683..94718,94740..94776) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 64.63 SAKL0E01287g1 1 95220 96542 ON 5 E01287 (95220..96542) Retrotransposon Gag gene Sklu_5.trna3V 1 101044 101117 ON 5 tV-AAC (101044..101117) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0E01342g 1 101847 102872 ON 5 E01342 (101847..102872) conserved hypothetical protein SAKL0E01364g 1 103009 104634 ON 5 E01364 (103009..104634) similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease SAKL0E01386g 1 105246 105872 ON 5 E01386 (105246..105872) highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family SAKL0E01408g 1 106229 107152 ON 5 E01408 (106229..107152) similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance Sklu_CEN5 0 108235 108420 ON 5 CEN5 complement(108235..108420) Chromosome V centromere SAKL0E01452g 1 108911 111124 ON 5 E01452 (108911..111124) similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus SAKL0E01474g 1 112382 113317 ON 5 E01474 (112382..113317) similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc Sklu_5.trna4T 0 113445 113517 ON 5 tT-AGU complement(113445..113517) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 SAKL0E01518g 1 113669 114808 ON 5 E01518 (113669..114808) similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC-CRD protein SAKL0E01540g 0 114922 119169 ON 5 E01540 complement(114922..119169) similar to uniprot|Q75CF0 Ashbya gossypii ACL004W ACL004Wp and some similarites with YOL004W uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation SAKL0E01562g 1 120177 120545 ON 5 E01562 (120177..120545) highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C SAKL0E01584g 0 121830 123917 ON 5 E01584 complement(121830..123917) highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C SAKL0E01606g 1 124738 126966 ON 5 E01606 (124738..126966) similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I SAKL0E01628g 1 127772 128695 ON 5 E01628 (127772..128695) weakly similar to uniprot|Q08054 Saccharomyces cerevisiae YOL007C Appears to be a structural component of the chitin synthase 3 complex SAKL0E01650g 1 128923 129399 ON 5 E01650 (128923..129399) highly similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF SAKL0E01672g 1 129954 130751 ON 5 E01672 (129954..130751) some similarities with uniprot|Q03673 Saccharomyces cerevisiae YMR003W Hypothetical ORF SAKL0E01694g 0 131246 131863 ON 5 E01694 complement(131246..131863) similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF SAKL0E01716g 1 131953 132852 ON 5 E01716 (131953..132852) similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae SAKL0E01738g 1 133104 134699 ON 5 E01738 (133104..134699) similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole SAKL0E01760g 0 134853 135956 ON 5 E01760 complement(134853..135956) highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase- like protein involved in rRNA processing at sites A0, A1, and A2 gnl|GLV|KLLA0C05984g Kluyveromyces lactis SAKL0E01782g 1 136231 137469 ON 5 E01782 (136231..137469) similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate Sklu_5.trna5V 0 137749 137822 ON 5 tV-AAC complement(137749..137822) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0E01848g 0 138253 139152 ON 5 E01848 complement(138253..139152) no similarity SAKL0E01870g 0 140327 142303 ON 5 E01870 complement(140327..142303) similar to uniprot|P39105 Saccharomyces cerevisiae YMR008C PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol SAKL0E01892g 0 144899 146842 ON 5 E01892 complement(144899..146842) similar to uniprot|P39105 Saccharomyces cerevisiae YMR008C PLB1 Phospholipase B (lysophospholipase) involved in lipid metabolism required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol SAKL0E01914g 1 147544 147948 ON 5 E01914 (147544..147948) highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin SAKL0E01936g 0 148394 148858 ON 5 E01936 complement(148394..148858) conserved hypothetical protein SAKL0E01958g 1 149087 150661 ON 5 E01958 (149087..150661) similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger SAKL0E01980g 0 150830 152227 ON 5 E01980 complement(150830..152227) similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor Sklu_5.trna6P 1 152658 152761 ON 5 tP-UGG (152658..152693,152726..152761) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.90 SAKL0E02024g 0 153037 154746 ON 5 E02024 complement(153037..154746) highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL SAKL0E02046g 1 156196 157899 ON 5 E02046 (156196..157899) weakly similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole SAKL0E02068g 1 158331 160007 ON 5 E02068 (158331..160007) similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long-chain base phosphates which function as signaling molecules and similar to YOR171c SAKL0E02090g 0 160194 160838 ON 5 E02090 complement(160194..160838) highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6 SAKL0E02112g 0 161567 161761 ON 5 E02112 complement(161567..161761) weakly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A SAKL0E02134g 0 162366 164771 ON 5 E02134 complement(162366..164771) highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions SAKL0E02156g 1 165228 167952 ON 5 E02156 (165228..165503,165604..167952) weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein involved in chromosome segregation during the first meiotic division SAKL0E02178g 1 168616 169025 ON 5 E02178 (168616..168618,168825..169025) highly similar to uniprot|P02380 Saccharomyces cerevisiae YLR264W RPS28B or highly similar to uniprot|P02380 Saccharomyces cerevisiae YOR167C RPS28A, ribosomal Proteins of the Small (40S) subunit SAKL0E02200g 0 171315 172850 ON 5 E02200 complement(171315..172850) similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation as well as for recycling of Golgi proteins and formation of lumenal membranes SAKL0E02222g 1 173149 174378 ON 5 E02222 (173149..174378) similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p and similar to YKL008C uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)- coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p SAKL0E02244g 0 175820 177019 ON 5 E02244 complement(175820..177019) similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit SAKL0E02266g 1 177238 177705 ON 5 E02266 (177238..177705) some similarities with uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in recombination SAKL0E02288g 0 177767 178483 ON 5 E02288 complement(177767..178483) highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus SAKL0E02310g 1 178743 183104 ON 5 E02310 (178743..183104) similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins Sklu_YGOB_Anc_2.496 1 185447 187306 ON 5 Anc_2.496 (185447..187306) ANNOTATED BY YGOB - SAKL0E02354g 0 187874 189607 ON 5 E02354 complement(187874..189607) similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p SAKL0E02376g 0 189843 191207 ON 5 E02376 complement(189843..191207) similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination SAKL0E02398g 0 191590 192294 ON 5 E02398 complement(191590..192294) conserved hypothetical protein SAKL0E02420g 0 192871 193839 ON 5 E02420 complement(192871..193839) some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor Sklu_5.trna7V 0 193978 194051 ON 5 tV-AAC complement(193978..194051) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0E02464g 1 195063 195371 ON 5 E02464 (195063..195371) no similarity SAKL0E02486g 0 196218 198395 ON 5 E02486 complement(196218..198395) similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint SAKL0E02508g 1 198617 199604 ON 5 E02508 (198617..198625,198705..199604) highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism products of which are regulators in Golgi to plasma membrane transport functionally homologous to mammalian PITPs SAKL0E02530g 1 199899 203291 ON 5 E02530 (199899..203291) similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types SAKL0E02552g 0 203608 206616 ON 5 E02552 complement(203608..206616) highly similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons SAKL0E02574g 0 207249 208175 ON 5 E02574 complement(207249..208175) conserved hypothetical protein SAKL0E02596g 0 208748 209704 ON 5 E02596 complement(208748..209704) similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles SAKL0E02618g 0 210003 210824 ON 5 E02618 complement(210003..210824) similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data SAKL0E02640g 0 211362 212366 ON 5 E02640 complement(211362..212366) some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization SAKL0E02662g 0 213396 213938 ON 5 E02662 complement(213396..213938) some similarities with uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles SAKL0E02684g 0 214237 215058 ON 5 E02684 complement(214237..215058) similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data SAKL0E02706g 0 215596 216600 ON 5 E02706 complement(215596..216600) some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization SAKL0E02728g 1 218003 218689 ON 5 E02728 (218003..218689) weakly similar to uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization Sklu_5.trna8K 0 219658 219730 ON 5 tK-CUU complement(219658..219730) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0E02772g 0 221312 222172 ON 5 E02772 complement(221312..222172) weakly similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF SAKL0E02794g 1 222400 223161 ON 5 E02794 (222400..223161) highly similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0E02816g 1 223754 225529 ON 5 E02816 (223754..225529) similar to uniprot|P34248 Saccharomyces cerevisiae YKL100C Hypothetical ORF SAKL0E02838g 1 226264 227397 ON 5 E02838 (226264..227397) uniprot|Q6XQ71 Saccharomyces kluyveri ADH4 Alcohol dehydrogenase 4 SAKL0E02860g 0 228726 232859 ON 5 E02860 complement(228726..232859) similar to uniprot|Q75DQ1 Ashbya gossypii ABL034W ABL034Wp and weakly similar to YKL101W uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p SAKL0E02882g 1 233814 235355 ON 5 E02882 (233814..235355) similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase SAKL0E02904g 1 236138 238249 ON 5 E02904 (236138..238249) highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6- P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis SAKL0E02926g 1 238748 241171 ON 5 E02926 (238748..241171) some similarities with uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0E02948g 0 241418 242689 ON 5 E02948 complement(241418..242689) similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis SAKL0E02970g 1 242852 243589 ON 5 E02970 (242852..243589) similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain SAKL0E02992g 0 243652 245364 ON 5 E02992 complement(243652..245364) similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane SAKL0E03014g 0 245756 248248 ON 5 E03014 complement(245756..248248) highly similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes SAKL0E03036g 0 248561 249910 ON 5 E03036 complement(248561..249910) similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import SAKL0E03058g 0 251271 253112 ON 5 E03058 complement(251271..253112) similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4 SAKL0E03080g 1 253338 254885 ON 5 E03080 (253338..254885) highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0E03102g 0 254974 256230 ON 5 E03102 complement(254974..256230) similar to uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Protein required for DNA replication phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks) phosphorylation is essential for DNA replication and for complex formation with Dpb11p potential Cdc28p substrate SAKL0E03124g 1 256468 257778 ON 5 E03124 (256468..257778) similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis SAKL0E03146g 0 257771 258394 ON 5 E03146 complement(257771..258394) similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1 SAKL0E03168g 1 258915 259799 ON 5 E03168 (258915..259799) highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase- induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1 SAKL0E03190g 0 260178 261971 ON 5 E03190 complement(260178..261971) conserved hypothetical protein SAKL0E03212g 0 262185 263360 ON 5 E03212 complement(262185..263360) similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane essential for respiratory competence likely functions in assembly of the large ribosomal subunit has homologs in plants and animals SAKL0E03234g 1 263522 264490 ON 5 E03234 (263522..264490) similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin SAKL0E03256g 0 264909 266708 ON 5 E03256 complement(264909..266708) similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF SAKL0E03278g 0 267317 268669 ON 5 E03278 complement(267317..268669) some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation gene silencing and DNA replication and repair SAKL0E03300g 1 269419 270564 ON 5 E03300 (269419..270564) highly similar to gnl|GLV|CAGL0K11506g Candida glabrata CAGL0K11506g and similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long- patch base-excision repair member of the S. pombe RAD2/FEN1 family SAKL0E03322g 1 270845 271918 ON 5 E03322 (270845..271918) similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'- repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations SAKL0E03344g 1 272024 273754 ON 5 E03344 (272024..273754) similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway SAKL0E03366g 1 274117 275007 ON 5 E03366 (274117..275007) highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF SAKL0E03388g 0 275112 275618 ON 5 E03388 complement(275112..275618) similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W Sklu_5.trna9A 0 275975 276047 ON 5 tA-AGC complement(275975..276047) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0E03432g 0 277075 278973 ON 5 E03432 complement(277075..278973) similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W SAKL0E03454g 1 279964 280737 ON 5 E03454 (279964..280737) similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex SAKL0E03476g 0 280734 281903 ON 5 E03476 complement(280734..281903) similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis SAKL0E03498g 0 282321 283295 ON 5 E03498 complement(282321..283295) highly similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family SAKL0E03520g 0 283754 286654 ON 5 E03520 complement(283754..286654) similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance SAKL0E03542g 1 287020 287496 ON 5 E03542 (287020..287496) similar to uniprot|Q75DP2 Ashbya gossypii ABL025C ABL025Cp and some similarites with YKL122C uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane SAKL0E03564g 0 287627 289246 ON 5 E03564 complement(287627..289246) similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions SAKL0E03586g 0 289625 291577 ON 5 E03586 complement(289625..291301,291380..291577) some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor SAKL0E03608g 0 291806 294007 ON 5 E03608 complement(291806..294007) similar to uniprot|P12688 Saccharomyces cerevisiae YKL126W YPK1 Serine/threonine protein kinase required for receptor-mediated endocytosis involved in sphingolipid- mediated and cell integrity signaling pathways localized to the bud neck cytosol and plasma membrane homolog of mammalian kinase SGK and to YMR104C uniprot|P18961 Saccharomyces cerevisiae YMR104C YPK2 Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK SAKL0E03630g 0 294321 296036 ON 5 E03630 complement(294321..296036) highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism SAKL0E03652g 0 296485 298365 ON 5 E03652 complement(296485..298365) similar to uniprot|Q04437 Saccharomyces cerevisiae YMR106C YKU80 Forms heterodimer with Yku70p known as Ku, binds chromosome ends and is involved in maintaining normal telomere length and structure, in addition to participating in the formation of silent chromatin at telomere-proximal genes Sklu_5.trna10K 0 298500 298572 ON 5 tK-CUU complement(298500..298572) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0E03696g 1 299396 299791 ON 5 E03696 (299396..299791) similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources SAKL0E03718g 1 300378 301217 ON 5 E03718 (300378..301217) similar to uniprot|P36069 Saccharomyces cerevisiae YKL128C PMU1 Phospho MUtase homolog. Small region homologous to active site of phospho-mutases these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1 bact. Pgm Hs Bpgm & rat fructose-2 6- bisphosphatase Phospo-mutase homolog SAKL0E03740g 1 302160 304199 ON 5 E03740 (302160..304199) highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control SAKL0E03762g 1 304782 308561 ON 5 E03762 (304782..308561) similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline- rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3 SAKL0E03784g 0 308703 310283 ON 5 E03784 complement(308703..310283) similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C Hypothetical ORF SAKL0E03806g 1 310408 311181 ON 5 E03806 (310408..311181) similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud SAKL0E03828g 0 311208 312215 ON 5 E03828 complement(311208..312215) similar to uniprot|Q758R1 Ashbya gossypii AEL308W AEL308Wp and weakly similar to YMR111C uniprot|Q04461 Saccharomyces cerevisiae YMR111C Hypothetical ORF SAKL0E03850g 0 312647 312982 ON 5 E03850 complement(312647..312982) similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 14 Kd mediator subunit of RNA polymerase II holoenzyme SAKL0E03872g 1 313098 314378 ON 5 E03872 (313098..314378) similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis SAKL0E03894g 0 314438 315307 ON 5 E03894 complement(314438..315307) some similarities with uniprot|Q04471 Saccharomyces cerevisiae YMR114C Hypothetical ORF SAKL0E03916g 1 315362 316810 ON 5 E03916 (315362..316810) uniprot|Q875N5 Saccharomyces kluyveri similar to YMR115W uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria SAKL0E03938g 1 317017 319320 ON 5 E03938 (317017..319320) similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis SAKL0E03960g 0 319708 320885 ON 5 E03960 complement(319708..320130,320346..320885) highly similar to with YMR116C uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G- beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1 SAKL0E04004g 1 322127 324274 ON 5 E04004 (322127..324274) similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin- associated protein (AP-1) complex SAKL0E04026g 0 324469 324795 ON 5 E04026 complement(324469..324795) similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF SAKL0E04048g 1 325050 325445 ON 5 E04048 (325050..325445) highly similar to gnl|GLV|CAGL0D02024g Candida glabrata CAGL0D02024g and similar to YKL138C uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit SAKL0E04070g 0 325506 326117 ON 5 E04070 complement(325506..326117) similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering Sklu_YGOB_Anc_2.426 1 326240 326449 ON 5 Anc_2.426 (326240..326449) ANNOTATED BY YGOB - SAKL0E04092g 0 326532 327982 ON 5 E04092 complement(326532..327901,327970..327982) similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing SAKL0E04114g 0 328285 329628 ON 5 E04114 complement(328285..329628) similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase one of three gene products (Yeh1p Yeh2p Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis localized to lipid particle membranes SAKL0E04136g 0 330058 330570 ON 5 E04136 complement(330058..330570) similar to uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone and some similarites with YMR118C uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF, member of GLR.231 SAKL0E04158g 0 331896 332636 ON 5 E04158 complement(331896..332636) conserved hypothetical protein Sklu_5.trna11R 0 332905 332976 ON 5 tR-UCU complement(332905..332976) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0E04202g 1 334212 334913 ON 5 E04202 (334212..334913) similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression SAKL0E04224g 0 335065 335988 ON 5 E04224 complement(335065..335988) similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport SAKL0E04246g 1 336416 338113 ON 5 E04246 (336416..338113) weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane SAKL0E04268g 0 338322 339587 ON 5 E04268 complement(338322..339587) highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate-grown cells Sklu_5.trna12L 1 340674 340796 ON 5 tL-CAA (340674..340711,340753..340796) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.10 SAKL0E04312g 1 341206 343140 ON 5 E04312 (341206..343140) similar to uniprot|P54074 Saccharomyces cerevisiae YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase genetic interactions suggest a role in negative regulation of amino acid uptake Sklu_YGOB_snR30 1 343356 343790 ON 5 snR30 (343356..343790) ANNOTATED BY YGOB - Sklu_YGOB_KLTH0E08976g 0 343637 343786 OFF 5 KLTH0E08976g complement(343637..343786) ANNOTATED BY YGOB - SAKL0E04334g 0 343998 345773 ON 5 E04334 complement(343998..345773) highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4- carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities isozyme of Ade16p ade16 ade17 mutants require adenine and histidine SAKL0E04356g 0 346184 346798 ON 5 E04356 complement(346184..346798) highly similar to uniprot|P54780 Saccharomyces cerevisiae RPL15B and to uniprot|P05748 Saccharomyces cerevisiae YLR029C RPL15A SAKL0E04378g 1 348403 348837 ON 5 E04378 (348403..348837) conserved hypothetical protein SAKL0E04400g 1 350441 350797 ON 5 E04400 (350441..350797) similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 Protein of unknown function overproduction confers resistance to Pichia farinosa killer toxin SAKL0E04422g 1 351683 354673 ON 5 E04422 (351683..354673) weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck SAKL0E04444g 1 354960 357861 ON 5 E04444 (354960..354984,355295..357861) similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex interacts with Npl3p to carry poly(A) mRNA from the nucleus to the cytoplasm also involved in mRNA degradation in the nucleus orthologous to mammalian CBP80 SAKL0E04466g 0 358057 359175 ON 5 E04466 complement(358057..359175) similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function deletion causes sensitivity to thermal stress SAKL0E04488g 1 359434 362817 ON 5 E04488 (359434..362817) similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 Single-stranded DNA-dependent ATPase involved in postreplication repair contains RING finger domain SAKL0E04510g 0 362939 363886 ON 5 E04510 complement(362939..363886) similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family SAKL0E04532g 1 364158 367979 ON 5 E04532 (364158..367979) similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP predominantly nucleolar in distribution required for 18S rRNA synthesis SAKL0E04554g 1 368195 369759 ON 5 E04554 (368195..368253,368319..369759) similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Remodels the structure of chromatin complex 58KDa subunit; Chromatin Remodeling Complex subunit SAKL0E04576g 0 369959 371380 ON 5 E04576 complement(369959..371380) highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative metal transporter Nramp homolog homolog of SMF1 and SMF2 SAKL0E04598g 1 371917 375750 ON 5 E04598 (371917..375750) similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase SAKL0E04620g 0 375896 378043 ON 5 E04620 complement(375896..378043) weakly similar to uniprot|Q07980 Saccharomyces cerevisiae YLR035C MLH2 Protein required for DNA mismatch repair in mitosis and meiosis involved in the repair of mutational intermediates forms a complex with Pms1p and Msh1p to repair mismatched DNA SAKL0E04642g 1 378154 379141 ON 5 E04642 (378154..378355,378429..379141) similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Hypothetical ORF Sklu_5.trna13A 0 379272 379344 ON 5 tA-UGC complement(379272..379344) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 73.87 SAKL0E04686g 1 379624 379890 ON 5 E04686 (379624..379890) some similarities with uniprot|P87287 Saccharomyces cerevisiae YDR366C Hypothetical ORF SAKL0E04708g 0 381081 381329 ON 5 E04708 complement(381081..381329) highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain required for assembly of fully active cytochrome c oxidase but not required for activity after assembly SAKL0E04730g 0 381559 384942 ON 5 E04730 complement(381559..384942) similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p involved in transcription of ribosomal protein genes and ribosomal RNA Sklu_YGOB_Anc_2.401 0 385202 386764 ON 5 Anc_2.401 complement(385202..386764) ANNOTATED BY YGOB - SAKL0E04752g 0 387164 387826 ON 5 E04752 complement(387164..387826) similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Hypothetical ORF SAKL0E04774g 1 388025 389200 ON 5 E04774 (388025..389200) weakly similar to uniprot|P32841 Saccharomyces cerevisiae YMR133W REC114 Protein involved in early stages of meiotic recombination possibly involved in the coordination of recombination and meiotic division mutations lead to premature initiation of the first meiotic division SAKL0E04796g 0 389292 390011 ON 5 E04796 complement(389292..390011) some similarities with uniprot|Q07988 Saccharomyces cerevisiae YLR040C Hypothetical ORF SAKL0E04807g 0 390498 391115 ON 5 E04807 complement(390498..391115) no similarity SAKL0E04818g 1 391898 392617 ON 5 E04818 (391898..392617) similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein required for cell viability SAKL0E04840g 0 392672 393859 ON 5 E04840 complement(392672..393859) similar to uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains LisH and CTLH domains like Vid30p SAKL0E04862g 1 394898 396643 ON 5 E04862 (394898..396643) weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 SAKL0E04884g 0 396992 398611 ON 5 E04884 complement(396992..398611) similar to uniprot|Q759M6 Ashbya gossypii ADR250C ADR250Cp and weakly similar to YMR137C uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Required for a post- incision step in the repair of DNA single and double- strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives induced by UV-irradiation SAKL0E04906g 1 398680 399306 ON 5 E04906 (398680..399306) similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl SAKL0E04928g 1 399919 400929 ON 5 E04928 (399919..400929) similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the glyoxylate cycle Sklu_YGOB_KLTH0E09636g 1 401383 401730 ON 5 KLTH0E09636g (401383..401730) ANNOTATED BY YGOB - SAKL0E04950g 1 401903 402994 ON 5 E04950 (401903..402994) highly similar to gnl|GLV|CAGL0L06820g Candida glabrata CAGL0L06820g and similar to YMR139W uniprot|P38615 Saccharomyces cerevisiae SAKL0E04972g 1 403578 405413 ON 5 E04972 (403578..405413) similar to uniprot|Q07471 Saccharomyces cerevisiae YDL080C THI3 Probable decarboxylase required for expression of enzymes involved in thiamine biosynthesis may have a role in catabolism of amino acids to long-chain and complex alcohols SAKL0E04994g 0 405972 407747 ON 5 E04994 complement(405972..407747) conserved hypothetical protein SAKL0E05016g 1 409503 410918 ON 5 E05016 (409503..410918) weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine SAKL0E05038g 1 411549 412988 ON 5 E05038 (411549..412988) similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase SAKL0E05060g 1 413501 413818 ON 5 E05060 (413501..413818) highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component SAKL0E05082g 0 414253 415236 ON 5 E05082 complement(414253..414848,415233..415236) uniprot|Q875Q4 Saccharomyces kluyveri RPL13 SAKL0E05104g 1 416358 417211 ON 5 E05104 (416358..416381,416804..417211) uniprot|Q875Q3 Saccharomyces kluyveri RPS16 SAKL0E05126g 1 418230 419336 ON 5 E05126 (418230..419336) some similarities with uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF SAKL0E05148g 0 419901 421372 ON 5 E05148 complement(419901..420979,421045..421372) highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase SAKL0E05170g 0 421524 422873 ON 5 E05170 complement(421524..422873) conserved hypothetical protein SAKL0E05236g 1 425965 426285 ON 5 E05236 (425965..426285) no similarity SAKL0E05258g 1 426681 428531 ON 5 E05258 (426681..428531) similar to uniprot|P53048 Saccharomyces cerevisiae YGR289C MAL11 Maltose permease inducible high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL1 complex locus member of the 12 transmembrane domain superfamily of sugar transporters SAKL0E05280g 0 429434 429673 ON 5 E05280 complement(429434..429673) conserved hypothetical protein SAKL0E05302g 0 431939 433546 ON 5 E05302 complement(431939..433546) highly similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase SAKL0E05324g 1 436428 438506 ON 5 E05324 (436428..438506) weakly similar to gnl|GLV|CAGL0B02926g Candida glabrata CAGL0B02926g SAKL0E05346g 0 439917 442172 ON 5 E05346 complement(439917..442172) weakly similar to gnl|GLV|CAGL0B02926g Candida glabrata CAGL0B02926g Sklu_YGOB_Anc_2.381 1 444184 444387 ON 5 Anc_2.381 (444184..444387) ANNOTATED BY YGOB - SAKL0E05368g 0 444630 445679 ON 5 E05368 complement(444630..445679) highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation SAKL0E05390g 0 446004 446825 ON 5 E05390 complement(446004..446825) similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W Hypothetical ORF SAKL0E05412g 1 447330 447785 ON 5 E05412 (447330..447785) similar to uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF SAKL0E05434g 1 447909 449346 ON 5 E05434 (447909..448501,448707..449346) some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W Hypothetical ORF SAKL0E05456g 1 449504 450346 ON 5 E05456 (449504..450346) similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit SAKL0E05478g 0 450482 451072 ON 5 E05478 complement(450482..451072) similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial SAKL0E05500g 0 451281 452420 ON 5 E05500 complement(451281..452420) similar to uniprot|Q03085 Saccharomyces cerevisiae YPL033C Hypothetical ORF SAKL0E05522g 1 452894 453766 ON 5 E05522 (452894..453766) highly similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site SAKL0E05544g 1 454954 456036 ON 5 E05544 (454954..456036) similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W SAKL0E05566g 1 457263 458612 ON 5 E05566 (457263..458612) similar to gnl|GLV|KLLA0F07227g Kluyveromyces lactis KLLA0F07227g and weakly similar to YDL088C uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p SAKL0E05588g 0 458799 460601 ON 5 E05588 complement(458799..460601) weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate SAKL0E05610g 0 460729 462831 ON 5 E05610 complement(460729..462831) weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C RIM13 SAKL0E05632g 1 463034 464293 ON 5 E05632 (463034..464293) similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 essential for processing of ras proteins beta subunit of farnesyltransferase SAKL0E05654g 1 464439 465764 ON 5 E05654 (464439..465764) similar to uniprot|Q12229 YDL091c Saccharomyces cerevisiae UBX3 UBX domain-containing protein that interacts with Cdc48p SAKL0E05676g 0 465795 466202 ON 5 E05676 complement(465795..466202) similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle subunit SAKL0E05698g 1 466494 468581 ON 5 E05698 (466494..468581) some similarities with uniprot|Q03795 Saccharomyces cerevisiae YMR155W Hypothetical ORF SAKL0E05720g 0 468851 471460 ON 5 E05720 complement(468851..471460) similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway acts in complex with Pmt2p dolichyl phosphate-D-mannose:protein O-D- mannosyltransferase SAKL0E05742g 1 473086 474024 ON 5 E05742 (473086..474024) similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase SAKL0E05764g 1 474594 475856 ON 5 E05764 (474594..475856) highly similar to uniprot|Q759J7 Ashbya gossypii ADR280W ADR280Wp and similar to YDL097C uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome the human homolog (S9 protein) partially rescues Rpn6p depletion SAKL0E05786g 0 475885 476625 ON 5 E05786 complement(475885..476625) similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage functionally redundant with Apn1p and Apn2p SAKL0E05808g 1 476777 477376 ON 5 E05808 (476777..477376) similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 23 kD U4/U6.U5 snRNP associated protein Putative RNA binding zinc finger protein SAKL0E05830g 0 477431 478117 ON 5 E05830 complement(477431..478117) similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C FMP39 The authentic non-tagged protein was localized to the mitochondria SAKL0E05852g 1 478353 478820 ON 5 E05852 (478353..478820) highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit SAKL0E05874g 0 478915 479916 ON 5 E05874 complement(478915..479916) similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0E05896g 1 480134 481183 ON 5 E05896 (480134..481183) highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C ARR4 ATPase involved in resistance to heat and metal stress active as a dimer normally localized to the cytosol but appears to localize to late endosomes under stress conditions Sklu_5.trna14M 0 481492 481564 ON 5 tM-CAU complement(481492..481564) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 SAKL0E05962g 1 482514 485828 ON 5 E05962 (482514..485828) highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W CDC2 Catalytic subunit of DNA polymerase delta required for chromosomal DNA replication during mitosis and meiosis intragenic recombination repair of double strand DNA breaks and DNA replication during nucleotide excision repair (NER) SAKL0E05984g 0 485895 487482 ON 5 E05984 complement(485895..487391,487462..487482) similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes phosphorylation of Rad55p and Sml1p and transient G2/M arrest after DNA damage also regulates postreplicative DNA repair SAKL0E06006g 0 487575 489815 ON 5 E06006 complement(487575..489815) similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Hypothetical ORF SAKL0E06028g 1 489875 490444 ON 5 E06028 (489875..490444) similar to uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre-autophagosomal structure essential for autophagy SAKL0E06050g 1 491382 492080 ON 5 E06050 (491382..492080) some similarities with uniprot|P48353 Saccharomyces cerevisiae YMR161W SAKL0E06072g 0 492380 497407 ON 5 E06072 complement(492380..497407) similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the trans-Golgi likely involved in protein transport Sklu_YGOB_Anc_2.348 1 497794 498897 ON 5 Anc_2.348 (497794..498897) ANNOTATED BY YGOB - SAKL0E06138g 0 498976 501027 ON 5 E06138 complement(498976..501027) similar to gnl|GLV|KLLA0E01694g Kluyveromyces lactis KLLA0E01694g and weakly similar to YMR163C uniprot|Q03824 Saccharomyces cerevisiae YMR163C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Sklu_5.trna15V 0 501378 501451 ON 5 tV-AAC complement(501378..501451) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0E06204g 0 503100 505109 ON 5 E06204 complement(503100..505109) some similarities with uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation controls the activation of MUC1 and STA2 in response to nutritional signals SAKL0E06226g 0 505827 508091 ON 5 E06226 complement(505827..508091) similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C SMP2 Protein involved in respiration and plasmid maintenance SAKL0E06248g 0 508609 509682 ON 5 E06248 complement(508609..509682) similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C Hypothetical ORF SAKL0E06270g 1 509899 511074 ON 5 E06270 (509899..511074) similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C SAKL0E06292g 0 511220 512350 ON 5 E06292 complement(511220..512350) similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex SAKL0E06314g 1 512498 514744 ON 5 E06314 (512498..512524,512588..514744) similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis postmeiotic segregation and spore viability forms a complex with Pms1p and Msh2p to repair mismatched DNA SAKL0E06336g 0 514759 516570 ON 5 E06336 complement(514759..516570) similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein component of the CBF3 complex that binds the CDEIII region of the centromere contains an N-terminal Zn2Cys6 type zinc finger domain a C-terminal acidic domain and a putative coiled coil dimerization domain SAKL0E06358g 0 516793 518301 ON 5 E06358 complement(516793..518301) highly similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytosolic aldehyde dehydrogenase that uses NAD as the preferred coenzyme expression is induced in response to high osmotic stress SAKL0E06380g 1 519266 520780 ON 5 E06380 (519266..520780) similar to uniprot|P47771 Saccharomyces cerevisiae YMR170c ALD5 and to uniprot|P54114 Saccharomyces cerevisiae YMR169c ALD4 SAKL0E06402g 1 521232 522707 ON 5 E06402 (521232..522707) similar to uniprot|Q755L6 Ashbya gossypii AFL202C AFL202Cp and weakly similar to YDL106C uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p SAKL0E06424g 0 523276 524982 ON 5 E06424 complement(523276..524982) similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C Endosomal protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p SAKL0E06446g 0 525860 528637 ON 5 E06446 complement(525860..528637) similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W SAKL0E06468g 1 528758 530566 ON 5 E06468 (528758..530566) similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1 2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog SAKL0E06490g 0 530588 531718 ON 5 E06490 complement(530588..531718) similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix required for export of C-terminal tail of Cox2p through the inner membrane SAKL0E06512g 1 532120 533331 ON 5 E06512 (532120..533331) conserved hypothetical protein SAKL0E06534g 0 533369 534358 ON 5 E06534 complement(533369..534267,534334..534358) highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase subunit of the transcription factor TFIIH involved in transcription initiation at RNA polymerase II promoters SAKL0E06556g 1 534482 535681 ON 5 E06556 (534482..535681) similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial polypeptide chain release factor involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation lack of MRF1 causes mitochondrial genome instability SAKL0E06578g 1 536140 538116 ON 5 E06578 (536140..538116) similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C ROG1 Protein with putative serine active lipase domain and similar to uniprot|Q12103 Saccharomyces cerevisiae YDL109C SAKL0E06600g 0 538263 540320 ON 5 E06600 complement(538263..540320) similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 transport protein that interacts with Sec20p required for protein transport from the endoplasmic reticulum to the golgi apparatus SAKL0E06622g 1 540546 541010 ON 5 E06622 (540546..541010) similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C Hypothetical ORF SAKL0E06644g 1 541327 542082 ON 5 E06644 (541327..542082) weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C Hypothetical ORF SAKL0E06666g 1 542730 543521 ON 5 E06666 (542730..543521) similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Ribosomal RNA Processing Component of the exosome 3->5 exoribonuclease complex with Rrp4p Rrp41p Rrp43p and Dis3p (Rrp44p). SAKL0E06688g 0 543877 548172 ON 5 E06688 complement(543877..548172) similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs SAKL0E06710g 1 548443 550347 ON 5 E06710 (548443..550347) similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway binds phosphatidylinositol-3-phosphate involved in localization of membranes to the preautophagosome potential Cdc28p substrate SAKL0E06732g 0 550449 551540 ON 5 E06732 complement(550449..551540) similar to uniprot|Q07530 Saccharomyces cerevisiae YDL114W Hypothetical ORF SAKL0E06754g 1 551956 553026 ON 5 E06754 (551956..552019,552089..553026) weakly similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin SAKL0E06776g 1 553435 554010 ON 5 E06776 (553435..554010) highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins SAKL0E06798g 0 554534 556705 ON 5 E06798 complement(554534..556705) similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup85p Nup120p Nup145p-C Sec13p and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis SAKL0E06820g 0 556960 559677 ON 5 E06820 complement(556960..559677) similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring mutant phenotype and genetic interactions suggest a role in cytokinesis SAKL0E06842g 0 560630 561760 ON 5 E06842 complement(560630..561760) highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase catalyzes the conversion of 5- enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate which is a precursor to aromatic amino acids SAKL0E06864g 1 563946 565667 ON 5 E06864 (563946..565667) similar to uniprot|Q9HFF8 Saccharomyces carlsbergensis FSY1 Fructose symporter SAKL0E06886g 1 566359 570339 ON 5 E06886 (566359..570339) similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C SAKL0E06908g 0 570437 573721 ON 5 E06908 complement(570437..573721) similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription SAKL0E06930g 0 573913 574932 ON 5 E06930 complement(573913..574932) similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p SAKL0E06952g 1 575094 575894 ON 5 E06952 (575094..575894) similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine SAKL0E06974g 1 576030 576929 ON 5 E06974 (576030..576929) similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C Hypothetical ORF SAKL0E06996g 0 576990 578081 ON 5 E06996 complement(576990..578081) similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis SAKL0E07018g 0 578410 581649 ON 5 E07018 complement(578410..581649) highly similar to uniprot|P22855 Saccharomyces cerevisiae YGL156W AMS1 vacuolar alpha mannosidase SAKL0E07040g 0 581924 582154 ON 5 E07040 complement(581924..582154) similar to uniprot|P01095 Saccharomyces cerevisiae YNL015W SAKL0E07062g 0 582690 583199 ON 5 E07062 complement(582690..583199) similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Yeast Frataxin Homologue mitochondrial protein that regulates mitochondrial iron accumulation SAKL0E07084g 1 583374 583814 ON 5 E07084 (583374..583814) weakly similar to uniprot|Q07541 Saccharomyces cerevisiae YDL121C Hypothetical ORF SAKL0E07106g 0 584164 586539 ON 5 E07106 complement(584164..586539) similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions irrespective of their size capable of cleaving polyubiquitin chains SAKL0E07128g 0 587416 588621 ON 5 E07128 complement(587416..588621) some similarities with uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly(A) RNA-binding protein abundant mRNP-component protein hypothesized to bind a pool of non-translatable mRNAs not reported to associate with polyribosomes Sklu_5.trna16I 0 588949 589022 ON 5 tI-AAU complement(588949..589022) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0E07172g 1 589348 590397 ON 5 E07172 (589348..590397) highly similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C Homolog to human PPCS SAKL0E07194g 0 590515 592002 ON 5 E07194 complement(590515..592002) similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria SAKL0E07216g 0 592229 593875 ON 5 E07216 complement(592229..593875) some similarities with uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation SAKL0E07238g 0 594623 595849 ON 5 E07238 complement(594623..595849) similar to uniprot|Q04235 Saccharomyces cerevisiae YML005W TRM12 Putative tRNA methyltransferase has a role in tRNA modification S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0E07260g 1 596055 597172 ON 5 E07260 (596055..596085,596280..597172) similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C SAKL0E07282g 1 597386 598972 ON 5 E07282 (597386..598972) similar to uniprot|P53966 Saccharomyces cerevisiae YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family SAKL0E07304g 0 599115 599426 ON 5 E07304 complement(599115..599426) highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity SAKL0E07326g 1 600006 600416 ON 5 E07326 (600006..600416) highly similar to uniprot|P61830 Saccharomyces cerevisiae YBR010W HHT1 and highly similar to uniprot|P61830 Saccharomyces cerevisiae YNL031C HHT2, histone H3 proteins SAKL0E07348g 1 600913 601365 ON 5 E07348 (600913..601365) similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C Hypothetical ORF SAKL0E07370g 0 601465 602265 ON 5 E07370 complement(601465..602265) similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis localized to the cytoplasm SAKL0E07392g 1 602503 603921 ON 5 E07392 (602503..603921) similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Sklu_5.trna17E 0 604057 604128 ON 5 tE-CUC complement(604057..604128) tRNA Type: Glu (E) | Anti-Codon: CUC | Cove Score: 64.72 SAKL0E07458g 0 606213 607292 ON 5 E07458 complement(606213..607292) weakly similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p SAKL0E07480g 0 607553 608452 ON 5 E07480 complement(607553..608452) highly similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation SAKL0E07524g 0 609285 610724 ON 5 E07524 complement(609285..610724) similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains mutations cause defects in cortical ER morphology in both the mother and daughter cells SAKL0E07546g 1 610979 613135 ON 5 E07546 (610979..613135) similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C Protein required for cell viability SAKL0E07568g 0 613454 613672 ON 5 E07568 complement(613454..613672) similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching SAKL0E07590g 1 613875 614657 ON 5 E07590 (613875..614657) similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit SAKL0E07612g 0 614835 615593 ON 5 E07612 complement(614835..615593) similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0E07634g 0 616444 619368 ON 5 E07634 complement(616444..619368) similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C SAKL0E07656g 1 620028 621134 ON 5 E07656 (620028..621134) highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate SAKL0E07678g 0 621183 622616 ON 5 E07678 complement(621183..622616) highly similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C SAKL0E07700g 1 622822 624960 ON 5 E07700 (622822..624960) highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer deletion increases histone H2B H3 and H4 acetylation SAKL0E07722g 0 625066 627441 ON 5 E07722 complement(625066..627441) similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W PRK1 Protein serine/threonine kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex Sklu_5.trna18I 1 628191 628264 ON 5 tI-AAU (628191..628264) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0E07766g 1 628373 629569 ON 5 E07766 (628373..629569) similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Hypothetical ORF SAKL0E07788g 1 629884 631572 ON 5 E07788 (629884..631572) similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB) which is involved in transcription of genes encoding tRNAs 5S rRNA U6 snRNA and other small RNAs SAKL0E07810g 1 631821 632330 ON 5 E07810 (631821..632330) weakly similar to uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-H protein SAKL0E07832g 1 632540 633529 ON 5 E07832 (632540..633529) similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Hypothetical ORF SAKL0E07854g 0 633573 635183 ON 5 E07854 complement(633573..635183) similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains CTLH domain SAKL0E07876g 0 635705 636790 ON 5 E07876 complement(635705..636790) highly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle SAKL0E07898g 1 637241 637738 ON 5 E07898 (637241..637738) weakly similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase SAKL0E07920g 0 638157 639977 ON 5 E07920 complement(638157..639977) similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation induced during starvation of a/a diploids late in sporulation but dispensable for sporulation SAKL0E07942g 1 640839 641483 ON 5 E07942 (640839..641483) similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions involved in non-classical protein export pathway SAKL0E07964g 1 642672 644621 ON 5 E07964 (642672..644621) similar to gnl|GLV|KLLA0F04015g Kluyveromyces lactis KLLA0F04015g and weakly similar to YIL101C uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes CYS3 and SMF2 expression is induced by stress or starvation during mitosis and late in meiosis member of the Swi4p/Mbp1p family potential Cdc28p substrate Sklu_5.trna19T 0 644867 644939 ON 5 tT-AGU complement(644867..644939) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 75.56 SAKL0E08008g 1 645124 647559 ON 5 E08008 (645124..647559) similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments SAKL0E08030g 0 647589 648872 ON 5 E08030 complement(647589..648872) highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p SAKL0E08052g 1 648903 650513 ON 5 E08052 (648903..650513) similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Essential nuclear protein required for accumulation of box H/ACA snoRNAs and for rRNA processing interacts with Naf1p SAKL0E08074g 0 650591 651598 ON 5 E08074 complement(650591..651598) similar to gnl|GLV|KLLA0F03927g Kluyveromyces lactis KLLA0F03927g and weakly similar to YNL042W uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function potential Cdc28p substrate overproduction suppresses a pam1 slv3 double null mutation SAKL0E08096g 0 651917 652522 ON 5 E08096 complement(651917..652423,652499..652522) similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Interacts with YPT proteins SAKL0E08118g 0 652712 654652 ON 5 E08118 complement(652712..654652) highly similar to gnl|GLV|KLLA0F03883g Kluyveromyces lactis KLLA0F03883g and similar to YNL045W uniprot|Q10740 Saccharomyces cerevisiae YNL045W Similar to human LTA4 hydrolase but in vivo substrates not yet defined. SAKL0E08140g 0 656248 656547 ON 5 E08140 complement(656248..656547) conserved hypothetical protein SAKL0E08162g 1 656921 659056 ON 5 E08162 (656921..659056) similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C SLM1 Phosphoinositide PI4 5P(2) binding protein forms a complex with Slm2p acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress phosphorylated by the Tor2p-containing complex TORC2 SAKL0E08184g 0 659294 661039 ON 5 E08184 complement(659294..661039) similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1 2-mannosyltransferase catalyzes addition of the terminal alpha 1 2-Man to the Man5GlcNAc2- PP-dolichol intermediate during asparagine-linked glycosylation in the ER SAKL0E08206g 0 661554 662443 ON 5 E08206 complement(661554..662358,662424..662443) similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Mps One Binder (putative) transcriptional regulator involved in mitosis SAKL0E08228g 1 662660 665047 ON 5 E08228 (662660..665047) similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A SAKL0E08250g 0 665150 667213 ON 5 E08250 complement(665150..667213) similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Hypothetical ORF SAKL0E08272g 1 668320 671034 ON 5 E08272 (668320..671034) similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C SEC24 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport vesicle coat component SAKL0E08294g 1 671388 672232 ON 5 E08294 (671388..671404,671494..672232) similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C Hypothetical ORF SAKL0E08316g 0 672310 673470 ON 5 E08316 complement(672310..673470) similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments SAKL0E08338g 0 673640 674755 ON 5 E08338 complement(673640..674755) similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0E08360g 0 675233 676011 ON 5 E08360 complement(675233..675684,676011..676011) highly similar to uniprot|P00424 Saccharomyces cerevisiae YNL052W COX5A Subunit Va of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic SAKL0E08382g 0 676318 679575 ON 5 E08382 complement(676318..679575) similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate SAKL0E08404g 0 680317 681729 ON 5 E08404 complement(680317..681729) similar to gnl|GLV|KLLA0F03597g Kluyveromyces lactis KLLA0F03597g and weakly similar to YNL053W uniprot|P38590 Saccharomyces cerevisiae YNL053W MSG5 Dual- specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway regulates and is regulated by Slt2p also required for adaptive response to pheromone SAKL0E08426g 0 682413 684953 ON 5 E08426 complement(682413..684953) similar to uniprot|P53950 Saccharomyces cerevisiae YNL054W VAC7 Integral vacuolar membrane protein may function to regulate Fab1p kinase activity SAKL0E08448g 1 686265 687110 ON 5 E08448 (686265..687110) highly similar to uniprot|P04840 Saccharomyces cerevisiae YNL055C POR1 Mitochondrial porin (voltage- dependent anion channel) outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability SAKL0E08470g 1 687678 691937 ON 5 E08470 (687678..691937) some similarities with uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side forms a subcomplex with Nup82p and Nsp1p required for mRNA export SAKL0E08492g 0 692049 693203 ON 5 E08492 complement(692049..693203) similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase catalyzes the seventh step in histidine biosynthesis responsive to general control of amino acid biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts SAKL0E08514g 0 693415 693933 ON 5 E08514 complement(693415..693933) highly similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive- strand RNA viruses in their natural hosts SAKL0E08536g 1 694243 695172 ON 5 E08536 (694243..695172) weakly similar to uniprot|P40476 Saccharomyces cerevisiae YIL117C PRM5 Pheromone-regulated protein predicted to have 1 transmembrane segment induced during cell integrity signaling SAKL0E08558g 0 695313 695990 ON 5 E08558 complement(695313..695990) highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p SAKL0E08580g 1 696452 702010 ON 5 E08580 (696452..702010) similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities SAKL0E08602g 1 702206 704449 ON 5 E08602 (702206..704449) similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes SAKL0E08624g 0 704579 706414 ON 5 E08624 complement(704579..706414) similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis localized to the nucleolus SAKL0E08646g 1 706740 708158 ON 5 E08646 (706740..708158) similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression SAKL0E08668g 0 708212 709093 ON 5 E08668 complement(708212..709093) similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1 SAKL0E08690g 1 709581 709988 ON 5 E08690 (709581..709988) no similarity SAKL0E08712g 1 710921 711586 ON 5 E08712 (710921..711586) some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation SAKL0E08734g 1 713258 714493 ON 5 E08734 (713258..714493) similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 yeast dnaJ homolog (nuclear envelope protein) heat shock protein SAKL0E08756g 0 714902 716599 ON 5 E08756 complement(714902..716599) similar to uniprot|P53943 Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane transporter of the major facilitator superfamily that confers resistance to short- chain monocarboxylic acids and quinidine SAKL0E08778g 0 716961 718763 ON 5 E08778 complement(716961..718763) similar to uniprot|P40474 Saccharomyces cerevisiae YIL121W QDR2 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) SAKL0E08800g 0 720729 721727 ON 5 E08800 complement(720729..721727) some similarities with uniprot|P40473 Saccharomyces cerevisiae YIL122W POG1 Promoter of Growth SAKL0E08822g 0 722456 723889 ON 5 E08822 complement(722456..723889) some similarities with gnl|GLV|KLLA0F04433g Kluyveromyces lactis KLLA0F04433g and some similarites with YIL123W uniprot|P40472 Saccharomyces cerevisiae YIL123W SIM1 (putative) invovled in control of DNA replication SAKL0E08844g 0 724533 725402 ON 5 E08844 complement(724533..725402) similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER involved in phosphatidic acid biosynthesis and required for spore germination capable of metabolizing mammalian steroid hormones SAKL0E08866g 0 726082 729117 ON 5 E08866 complement(726082..729117) highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a key step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA SAKL0E08888g 0 729693 730268 ON 5 E08888 complement(729693..730268) highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins SAKL0E08910g 0 730567 734409 ON 5 E08910 complement(730567..734409) similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 helicase related protein snf2 homolog SAKL0E08932g 1 734806 735417 ON 5 E08932 (734806..735417) similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C Hypothetical ORF SAKL0E08954g 0 735477 738536 ON 5 E08954 complement(735477..738536) similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription SAKL0E08976g 1 738990 746813 ON 5 E08976 (738990..746813) similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Identified in a hunt for mutants that activate OCH1 transcription Transcriptional Activator of OCH1 SAKL0E08998g 0 747085 749556 ON 5 E08998 complement(747085..749556) similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins SAKL0E09020g 1 750241 752289 ON 5 E09020 (750241..752289) similar to uniprot|P41813 Saccharomyces cerevisiae YNL068C FKH2 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth also involved in chromatin silencing at HML and HMR potential Cdc28p substrate SAKL0E09042g 1 752713 753327 ON 5 E09042 (752713..753327) similar to uniprot|P40465 Saccharomyces cerevisiae YIL132C CSM2 Protein required for accurate chromosome segregation during meiosis SAKL0E09064g 1 753818 754794 ON 5 E09064 (753818..753851,754226..754794) highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p and to YNL069C uniprot|P26785 Saccharomyces cerevisiae YNL069C RPL16B N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p SAKL0E09086g 0 754996 755928 ON 5 E09086 complement(754996..755928) similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria where it is synthesized from riboflavin to the cytosol Sklu_YGOB_Anc_2.226 0 756346 756528 ON 5 Anc_2.226 complement(756346..756528) ANNOTATED BY YGOB - SAKL0E09108g 0 757410 758825 ON 5 E09108 complement(757410..758825) similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA SAKL0E09130g 0 759397 760290 ON 5 E09130 complement(759397..760290) highly similar to gnl|GLV|CAGL0J10208g Candida glabrata CAGL0J10208g and similar to YNL072W uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit removes RNA primers during Okazaki fragment synthesis cooperates with Rad27p nuclease SAKL0E09152g 0 760468 762081 ON 5 E09152 complement(760468..762081) similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria SAKL0E09218g 1 765587 766813 ON 5 E09218 (765587..766813) some similarities with uniprot|P40463 Saccharomyces cerevisiae YIL135C VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation SAKL0E09240g 0 767385 768236 ON 5 E09240 complement(767385..768236) highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome which is required for pre-18S rRNA processing interacts with Mpp10p member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs SAKL0E09262g 0 768520 770496 ON 5 E09262 complement(768520..770496) weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling SAKL0E09284g 0 771136 772830 ON 5 E09284 complement(771136..772830) weakly similar to uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function major constituent of the mitochondrial outer membrane located on the outer (cytosolic) face of the outer membrane SAKL0E09306g 0 773968 775353 ON 5 E09306 complement(773968..775353) similar to uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family overexpression interferes with propagation of the [Psi ] prion SAKL0E09328g 0 777554 778729 ON 5 E09328 complement(777554..778729) similar to uniprot|P53938 Saccharomyces cerevisiae YNL080C SAKL0E09350g 0 778947 779493 ON 5 E09350 complement(778947..779414,779476..779493) similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C TPM2 Tropomyosin isoform 2 actin-binding protein that stabilizes actin filaments required with Tpm1 the main tropomyosin for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles SAKL0E09372g 1 780115 781935 ON 5 E09372 (780115..781935) weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase physically interacts with septins possibly involved in a mitotic signaling network SAKL0E09394g 0 782108 784804 ON 5 E09394 complement(782108..784804) similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C RBF108 Hypothetical ORF SAKL0E09416g 1 786273 786710 ON 5 E09416 (786273..786710) highly similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2 SAKL0E09438g 0 786794 789430 ON 5 E09438 complement(786794..789430) similar to uniprot|Q8TG57 Saccharomyces cerevisiae YNL082W SAKL0E09460g 1 789570 790280 ON 5 E09460 (789570..790280) similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage SAKL0E09482g 0 790392 791933 ON 5 E09482 complement(790392..791933) highly similar to gnl|GLV|KLLA0C11363g Kluyveromyces lactis KLLA0C11363g and similar to YNL083W uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 -binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains Sklu_5.trna20T 1 792805 792877 ON 5 tT-AGU (792805..792877) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 75.56 SAKL0E09548g 1 793647 795209 ON 5 E09548 (793647..795209) conserved hypothetical protein SAKL0E09570g 0 795670 798138 ON 5 E09570 complement(795670..798138) some similarities with uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate SAKL0E09592g 1 799364 800503 ON 5 E09592 (799364..800503) similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p SAKL0E09614g 0 800669 802195 ON 5 E09614 complement(800669..802195) highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo Sklu_5.trna21T 0 802665 802737 ON 5 tT-AGU complement(802665..802737) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 75.56 SAKL0E09658g 1 802880 805324 ON 5 E09658 (802880..805324) weakly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family SAKL0E09680g 0 806002 808413 ON 5 E09680 complement(806002..808413) similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease SAKL0E09702g 1 808613 809665 ON 5 E09702 (808613..809665) similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins SAKL0E09724g 0 809721 810032 ON 5 E09724 complement(809721..810032) similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF SAKL0E09746g 0 810206 813724 ON 5 E09746 complement(810206..813724) similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact SAKL0E09768g 0 813986 818332 ON 5 E09768 complement(813986..818332) highly similar to gnl|GLV|CAGL0J05610g Candida glabrata CAGL0J05610g uniprot|O93794 Candida glabrata DNA topoisomerase II identified start CAGL0J05610g|CAGL- IPF7937|CAGL-CDS0143.1 and similar to YNL088W uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis Sklu_5.trna22N 1 819064 819137 ON 5 tN-GUU (819064..819137) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0E09834g 0 819736 820308 ON 5 E09834 complement(819736..820308) highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly SAKL0E09856g 0 820709 824518 ON 5 E09856 complement(820709..824518) some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 SAKL0E09878g 1 825206 827236 ON 5 E09878 (825206..827236) similar to uniprot|Q12324 Saccharomyces cerevisiae YOR087W, Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock SAKL0E09900g 0 827263 828456 ON 5 E09900 complement(827263..828456) similar to uniprot|P53934 Saccharomyces cerevisiae YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0E09922g 0 829249 829890 ON 5 E09922 complement(829249..829890) similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association SAKL0E09944g 0 830158 831825 ON 5 E09944 complement(830158..831825) similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown SAKL0E09966g 1 832154 833191 ON 5 E09966 (832154..833191) similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF SAKL0E09988g 0 833401 835242 ON 5 E09988 complement(833401..835242) similar to uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein- protein interactions in large-scale studies suggests a possible role in actin filament organization SAKL0E10010g 1 835921 837552 ON 5 E10010 (835921..837552) similar to uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non-essential protein of unknown function SAKL0E10032g 0 837606 842486 ON 5 E10032 complement(837606..842486) similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF SAKL0E10054g 1 843076 843621 ON 5 E10054 (843076..843621) highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP- ribosylation factor GTPase of the Ras superfamily involved in development of polarity SAKL0E10076g 0 843808 844644 ON 5 E10076 complement(843808..844644) similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase SAKL0E10098g 1 846194 847120 ON 5 E10098 (846194..846337,846692..847120) highly similar to uniprot|Q08502 Saccharomyces cerevisiae YOR096W SAKL0E10120g 0 847289 847744 ON 5 E10120 complement(847289..847744) some similarities with uniprot|Q12274 Saccharomyces cerevisiae YOR097C Hypothetical ORF SAKL0E10142g 0 848513 851134 ON 5 E10142 complement(848513..851134) weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit involved in protein import/export and in export of RNAs possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC potential Cdc28p substrate SAKL0E10164g 1 851255 852604 ON 5 E10164 (851255..852604) highly similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family SAKL0E10186g 0 852843 853796 ON 5 E10186 complement(852843..853796) similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Sklu_5.trna23L 0 854102 854224 ON 5 tL-CAA complement(854102..854145,854187..854224) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.10 SAKL0E10230g 1 854280 855464 ON 5 E10230 (854280..855464) some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C SAKL0E10252g 1 855721 856691 ON 5 E10252 (855721..855735,855900..856691) similar to uniprot|P01119 Saccharomyces cerevisiae YOR101W RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes SAKL0E10274g 0 857004 857390 ON 5 E10274 complement(857004..857390) similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins SAKL0E10296g 1 857577 858215 ON 5 E10296 (857577..858215) similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA SAKL0E10318g 1 858835 859566 ON 5 E10318 (858835..859566) similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced SAKL0E10340g 0 859680 860465 ON 5 E10340 complement(859680..860465) similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W Hypothetical ORF SAKL0E10362g 0 860653 862854 ON 5 E10362 complement(860653..862854) similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters SAKL0E10384g 0 863204 867616 ON 5 E10384 complement(863204..867616) similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha- primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis SAKL0E10406g 1 867905 868735 ON 5 E10406 (867905..868735) similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog SAKL0E10428g 0 868913 870703 ON 5 E10428 complement(868913..870703) weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p SAKL0E10450g 1 871593 872369 ON 5 E10450 (871593..872369) some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose- induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p SAKL0E10472g 1 873925 875751 ON 5 E10472 (873925..875751) highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2- isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway SAKL0E10494g 1 876206 879553 ON 5 E10494 (876206..879553) similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5- phosphatase SAKL0E10516g 1 880093 880746 ON 5 E10516 (880093..880746) conserved hypothetical protein SAKL0E10538g 0 880749 881411 ON 5 E10538 complement(880749..881411) similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p has homology to human leukemogenic protein AF9 contains a YEATS domain SAKL0E10560g 1 881552 882840 ON 5 E10560 (881552..881581,881650..882840) uniprot|Q875N3 Saccharomyces kluyveri TFC7 SAKL0E10582g 1 882964 883623 ON 5 E10582 (882964..883623) similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF SAKL0E10604g 1 884025 884690 ON 5 E10604 (884025..884690) similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm SAKL0E10626g 1 885272 885643 ON 5 E10626 (885272..885643) similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation SAKL0E10648g 1 886303 888555 ON 5 E10648 (886303..888555) similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W Hypothetical ORF SAKL0E10670g 0 888829 891281 ON 5 E10670 complement(888829..889205,889934..891281) similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing SAKL0E10692g 0 891637 892032 ON 5 E10692 complement(891637..892032) highly similar to uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III SAKL0E10714g 1 892885 895344 ON 5 E10714 (892885..895344) weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance SAKL0E10736g 1 895862 896668 ON 5 E10736 (895862..896668) similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Hypothetical ORF SAKL0E10758g 0 896773 897558 ON 5 E10758 complement(896773..897558) similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic SAKL0E10780g 1 897714 899591 ON 5 E10780 (897714..899591) similar to uniprot|Q75BK5 Ashbya gossypii ACR266W ACR266Wp and some similarites with YHR114W uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization able to recruit actin polymerization machinery through its SH3 domains colocalizes with cortical actin patches and Las17p interacts with type I myosins SAKL0E10802g 1 900131 902038 ON 5 E10802 (900131..902038) similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Hypothetical ORF SAKL0E10824g 0 902623 904050 ON 5 E10824 complement(902623..904050) similar to uniprot|Q75BK4 Ashbya gossypii ACR267C ACR267Cp and some similarites with YNL116W uniprot|P53924 Saccharomyces cerevisiae YNL116W DMA2 Protein involved in regulating spindle position and orientation functionally redundant with Dma1p homolog of S. pombe Dma1 and H. sapiens Chfr SAKL0E10846g 0 904637 906301 ON 5 E10846 complement(904637..906301) highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase enzyme of the glyoxylate cycle involved in utilization of non- fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium SAKL0E10868g 0 908618 909505 ON 5 E10868 complement(908618..909505) conserved hypothetical protein SAKL0E10890g 1 910014 912569 ON 5 E10890 (910014..912569) similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Protein required for the decapping of mRNAs functions to allow the production of active Dcp1p contains a pyrophosphatase MutT motif and several alpha-helical leucine-rich motifs SAKL0E10912g 0 912654 914069 ON 5 E10912 complement(912654..914069) similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth inhibits replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0E10934g 1 916050 916391 ON 5 E10934 (916050..916391) highly similar to gnl|GLV|CAGL0I02728g Candida glabrata CAGL0I02728g and similar to YHR116W uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis essential for functional cytochrome oxidase expression homologous to Cox17p SAKL0E10956g 1 916623 918425 ON 5 E10956 (916623..918425) similar to uniprot|P07213 Saccharomyces cerevisiae YNL121C TOM70 Translocase of Outer Mitochondrial membrane 70 kDa mitochondrial specialized import receptor of the outer membrane SAKL0E10978g 1 919541 919828 ON 5 E10978 (919541..919828) some similarities with uniprot|P53921 Saccharomyces cerevisiae YNL122C Hypothetical ORF SAKL0E11000g 0 920034 922982 ON 5 E11000 complement(920034..922982) highly similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W shows protein sequence similarity to the mammalian Omi/HtrA2 family of serine proteases SAKL0E11022g 0 923227 924588 ON 5 E11022 complement(923227..924588) similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p SAKL0E11044g 1 925511 928576 ON 5 E11044 (925511..928576) similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres contains a SET domain SAKL0E11066g 1 928800 931697 ON 5 E11066 (928800..931697) similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis SAKL0E11088g 0 931727 933271 ON 5 E11088 complement(931727..933271) weakly similar to uniprot|P53919 Saccharomyces cerevisiae YNL124W SAKL0E11110g 1 933600 935456 ON 5 E11110 (933600..935456) similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane SAKL0E11132g 0 935578 938100 ON 5 E11132 complement(935578..938100) similar to uniprot|P53540 Saccharomyces cerevisiae YNL126W SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque SAKL0E11154g 0 938270 941041 ON 5 E11154 complement(938270..941041) similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far8p Far9p and Far10p SAKL0E11176g 1 941197 941751 ON 5 E11176 (941197..941751) similar to uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein containing an Lsm domain and an AD domain may bind RNA and have a role in RNA processing SAKL0E11198g 0 941879 943261 ON 5 E11198 complement(941879..943261) similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W SAKL0E11220g 0 943433 944209 ON 5 E11220 complement(943433..944086,944150..944209) similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside involved in a salvage pathway for NAD biosynthesis SAKL0E11242g 1 944430 945101 ON 5 E11242 (944430..945101) similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein required for cell viability SAKL0E11264g 1 945306 946541 ON 5 E11264 (945306..945355,945419..946541) similar to uniprot|P17898 Saccharomyces cerevisiae YNL130C CPT1 and similar to uniprot|P22140 Saccharomyces cerevisiae YHR123w Cholinephosphotransferase required for phosphatidylcholine biosynthesis and for inositol- dependent regulation of EPT1 transcription SAKL0E11286g 0 946730 947200 ON 5 E11286 complement(946730..947200) similar to uniprot|Q74Z61 Ashbya gossypii AGR345C AGR345Cp and some similarities with uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Translocase of Outer Mitochondrial membrane Mitochondrial import receptor complex protein SAKL0E11308g 0 947650 950817 ON 5 E11308 complement(947650..950817) highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance SAKL0E11330g 1 952071 954182 ON 5 E11330 (952071..954182) some similarities with uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination activates middle sporulation genes competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Sklu_5.trna24F 0 954557 954649 ON 5 tF-GAA complement(954557..954592,954613..954649) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.92 SAKL0E11374g 1 955340 955843 ON 5 E11374 (955340..955843) similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function required for survival upon exposure to K1 killer toxin proposed to regulate double-strand break repair via non-homologous end- joining SAKL0E11396g 1 956219 957337 ON 5 E11396 (956219..957337) similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C SAKL0E11418g 0 959479 960597 ON 5 E11418 complement(959479..960597) similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C SAKL0E11440g 0 961217 961915 ON 5 E11440 complement(961217..961915) conserved hypothetical protein SAKL0E11462g 1 963046 963390 ON 5 E11462 (963046..963390) highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function SAKL0E11484g 0 963453 964487 ON 5 E11484 complement(963453..964487) some similarities with uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex which acetylates the N- terminal tails of histones H4 and H2A SAKL0E11506g 1 964671 966116 ON 5 E11506 (964671..966116) similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit SAKL0E11528g 0 966278 967849 ON 5 E11528 complement(966278..967849) similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 Adenylyl cyclase-associated protein N- terminal domain appears to be involved in cellular responsiveness to RAS SAKL0E11550g 1 968027 968689 ON 5 E11550 (968027..968689) similar to uniprot|P38833 Saccharomyces cerevisiae YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4 SAKL0E11572g 1 969462 970331 ON 5 E11572 (969462..970331) conserved hypothetical protein SAKL0E11594g 0 970406 970729 ON 5 E11594 complement(970406..970660,970727..970729) similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A RCP10 SAKL0E11616g 1 970904 975868 ON 5 E11616 (970904..975868) similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C RLR1 Required for LacZ RNA expression from certain plasmids suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) plays a role in transcription elongation by RNA polymerase II Involved in transcription SAKL0E11638g 1 976034 977170 ON 5 E11638 (976034..977170) similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W Protein required for cell viability SAKL0E11660g 1 977607 978689 ON 5 E11660 (977607..978689) conserved hypothetical protein SAKL0E11682g 0 978761 979471 ON 5 E11682 complement(978761..979471) similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31 contains HMG- like C-terminal domain SAKL0E11704g 0 979698 980078 ON 5 E11704 complement(979698..980078) similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C Protein required for cell viability SAKL0E11726g 1 980309 980557 ON 5 E11726 (980309..980557) no similarity SAKL0E11748g 0 980870 981604 ON 5 E11748 complement(980870..981604) similar to uniprot|Q754L8 Ashbya gossypii AFR054W AFR054Wp and weakly similar to YNL148C uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 alpha-tubulin foldin protein implicated in folding of alpha tubulin cofactor B SAKL0E11770g 1 981788 982256 ON 5 E11770 (981788..981799,981924..982256) highly similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay SAKL0E11792g 1 983425 984075 ON 5 E11792 (983425..984075) highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase synthesizes UMP from uracil involved in the pyrimidine salvage pathway SAKL0E11814g 0 984199 985338 ON 5 E11814 complement(984199..985338) highly similar to gnl|GLV|KLLA0E23012g Kluyveromyces lactis KLLA0E23012g and similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin- related protein of the dynactin complex required for spindle orientation and nuclear migration putative ortholog of mammalian centractin SAKL0E11836g 0 985553 987418 ON 5 E11836 complement(985553..987418) conserved hypothetical protein Sklu_YGOB_YNL146W 1 987816 988197 ON 5 YNL146W (987816..987948,988010..988197) ANNOTATED BY YGOB - Intron annotated manually. KW. SAKL0E11858g 0 989175 991466 ON 5 E11858 complement(989175..991466) similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C Hypothetical ORF SAKL0E11880g 0 992168 993418 ON 5 E11880 complement(992168..993418) conserved hypothetical protein SAKL0E11902g 0 994140 994910 ON 5 E11902 complement(994140..994910) some similarities with uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Predicted membrane protein genetic interactions suggest a role in negative regulation of amino acid uptake SAKL0E11924g 1 995053 995622 ON 5 E11924 (995053..995622) similar to uniprot|Q754M6 Ashbya gossypii AFR046C AFR046Cp and weakly similar to YNL158W uniprot|P53896 Saccharomyces cerevisiae YNL158W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery SAKL0E11946g 0 995648 996985 ON 5 E11946 complement(995648..996985) similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C SAKL0E11968g 1 997943 998335 ON 5 E11968 (997943..998335) highly similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A Hypothetical ORF SAKL0E11990g 0 998398 999162 ON 5 E11990 complement(998398..999162) similar to uniprot|P53898 Saccharomyces cerevisiae YNL156C NSG2 Protein of unknown function potential homolog of mammalian Insig 1 SAKL0E12012g 1 999432 1000202 ON 5 E12012 (999432..1000202) similar to uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 weak suppressor of smt3 SAKL0E12034g 0 1000557 1001177 ON 5 E12034 complement(1000557..1001177) conserved hypothetical protein SAKL0E12056g 1 1001753 1002532 ON 5 E12056 (1001753..1002532) similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Hypothetical ORF SAKL0E12078g 1 1002730 1003818 ON 5 E12078 (1002730..1003818) similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W Oxidoreductase SAKL0E12100g 0 1004036 1005622 ON 5 E12100 complement(1004036..1005622) some similarities with uniprot|P23292 Saccharomyces cerevisiae YNL154C YCK2 membrane-bound casein kinase I homolog SAKL0E12122g 1 1006096 1007163 ON 5 E12122 (1006096..1007163) similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase) involved in purine salvage and nitrogen catabolism SAKL0E12144g 0 1007321 1008046 ON 5 E12144 complement(1007321..1008046) conserved hypothetical protein SAKL0E12166g 1 1009032 1009799 ON 5 E12166 (1009032..1009799) conserved hypothetical protein SAKL0E12188g 1 1010503 1012095 ON 5 E12188 (1010503..1012095) similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase catalyzes the first step of tryptophan phenylalanine and tyrosine catabolism SAKL0E12210g 1 1012587 1013037 ON 5 E12210 (1012587..1012595,1012657..1013037) highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it SAKL0E12232g 0 1013338 1013774 ON 5 E12232 complement(1013338..1013609,1013702..1013774) similar to uniprot|P38841 Saccharomyces cerevisiae YHR138C Homologous to PBI2 SAKL0E12254g 0 1014279 1015787 ON 5 E12254 complement(1014279..1015787) similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+) expression is under the nitrogen catabolite repression regulation SAKL0E12276g 0 1016243 1016740 ON 5 E12276 complement(1016243..1016740) no similarity SAKL0E12298g 0 1017680 1018663 ON 5 E12298 complement(1017680..1018663) similar to uniprot|P38616 Saccharomyces cerevisiae YNL160W YGP1 may be involved in cellular adaptations prior to stationary phase YGP1 encodes gp37 a glycoprotein synthesized in response to nutrient limitation which is homologous to the sporulation-specific SPS100 gene SAKL0E12320g 1 1019844 1020506 ON 5 E12320 (1019844..1020506) similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Hypothetical ORF SAKL0E12342g 0 1021369 1023795 ON 5 E12342 complement(1021369..1023795) some similarities with uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Protein kinase involved in cell wall biosynthesis required for efficient apical growth proper mating projection morphology bipolar bud site selection in diploid cells and cell separation SAKL0E12364g 0 1024170 1024917 ON 5 E12364 complement(1024170..1024486,1024914..1024917) highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C RPL42B and and highly similar to uniprot|P02405 Saccharomyces cerevisiae YNL162W RPL42A, Proteins component of the large (60S) ribosomal subunit SAKL0E12386g 1 1025787 1026740 ON 5 E12386 (1025787..1026740) highly similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7 SAKL0E12408g 0 1026855 1027067 ON 5 E12408 complement(1026855..1027067) similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. SAKL0E12430g 1 1027231 1030554 ON 5 E12430 (1027231..1030554) similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C SAKL0E12452g 1 1030876 1031859 ON 5 E12452 (1030876..1031859) some similarities with uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway interacts with Bfa1p and functions upstream of Bub2p and Bfa1p SAKL0E12474g 1 1032742 1033530 ON 5 E12474 (1032742..1033530) some similarities with uniprot|P38844 Saccharomyces cerevisiae YHR143W SAKL0E12496g 0 1033745 1034878 ON 5 E12496 complement(1033745..1034878) similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF SAKL0E12518g 1 1035137 1036321 ON 5 E12518 (1035137..1036321) highly similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck may interact directly with the Cdc11p septin localizes to bud neck in a septin- dependent manner SAKL0E12540g 1 1036526 1036738 ON 5 E12540 (1036526..1036738) highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10- alpha common to RNA polymerases I II and III SAKL0E12562g 1 1037155 1038825 ON 5 E12562 (1037155..1038825) some similarities with uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family that forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in the osmotic and oxidative stress responses SAKL0E12584g 1 1039156 1039938 ON 5 E12584 (1039156..1039938) highly similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 The authentic non-tagged protein was localized to mitochondria SAKL0E12606g 0 1039985 1040974 ON 5 E12606 complement(1039985..1040974) similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deaminase required for dCTP and dTTP synthesis expression is cell cycle regulated SAKL0E12628g 1 1041134 1042603 ON 5 E12628 (1041134..1042603) similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane converts phosphatidylserine to phosphatidylethanolamine SAKL0E12650g 0 1042706 1047727 ON 5 E12650 complement(1042706..1047727) similar to uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition Sklu_5.trna25P 0 1047859 1047962 ON 5 tP-UGG complement(1047859..1047894,1047927..1047962) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.75 SAKL0E12716g 1 1049450 1052215 ON 5 E12716 (1049450..1052215) some similarities with uniprot|P38845 Saccharomyces cerevisiae YHR146W CRP1 Protein that binds to cruciform DNA structures SAKL0E12738g 1 1052695 1053885 ON 5 E12738 (1052695..1053885) similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C SAKL0E12760g 1 1054345 1055607 ON 5 E12760 (1054345..1055607) conserved hypothetical protein SAKL0E12782g 1 1056428 1057342 ON 5 E12782 (1056428..1057342) similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit SAKL0E12804g 0 1057505 1058101 ON 5 E12804 complement(1057505..1058101) similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface SAKL0E12826g 0 1058505 1059251 ON 5 E12826 complement(1058505..1059251) highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit SAKL0E12848g 1 1060050 1060835 ON 5 E12848 (1060050..1060835) similar to gnl|GLV|KLLA0D08327g Kluyveromyces lactis KLLA0D08327g and weakly similar to YNL180C uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non- essential small GTPase of the Rho/Rac subfamily of Ras- like proteins likely involved in protein kinase C (Pkc1p)- dependent signal transduction pathway that controls cell integrity SAKL0E12870g 0 1061052 1062224 ON 5 E12870 complement(1061052..1062224) highly similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Protein required for cell viability SAKL0E12892g 1 1062422 1064002 ON 5 E12892 (1062422..1064002) similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Protein required for cell viability computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunit SAKL0E12914g 0 1064084 1064434 ON 5 E12914 complement(1064084..1064434) conserved hypothetical protein SAKL0E12936g 1 1064664 1065302 ON 5 E12936 (1064664..1065302) some similarities with uniprot|Q07623 Saccharomyces cerevisiae YDL213C SAKL0E12958g 1 1066434 1068653 ON 5 E12958 (1066434..1068653) similar to uniprot|P22211 Saccharomyces cerevisiae YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation SAKL0E12980g 1 1069475 1069924 ON 5 E12980 (1069475..1069924) highly similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit SAKL0E13002g 0 1070150 1072369 ON 5 E13002 complement(1070150..1072369) similar to uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties may regulate silencing by acting on Sir4p involved in posttranscriptionally regulating Gap1p and possibly other transporters primarily located in the nucleus SAKL0E13024g 1 1073407 1076517 ON 5 E13024 (1073407..1076517) highly similar to uniprot|Q750J1 Ashbya gossypii AGL040C AGL040Cp and similar to YDL215C uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD( )-dependent glutamate dehydrogenase degrades glutamate to ammonia and alpha- ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels SAKL0E13046g 1 1076910 1078151 ON 5 E13046 (1076910..1078151) similar to uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 subunit of COP9 signalosome (CSN) COP9 signalosome SAKL0E13068g 0 1078146 1079384 ON 5 E13068 complement(1078146..1079384) similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W Non-essential protein with putative leucine-rich nuclear export signal (NES) sequence that fits the consensus sequence recognized by Crm1p SAKL0E13090g 1 1079563 1080153 ON 5 E13090 (1079563..1080153) highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family SAKL0E13112g 0 1080203 1081237 ON 5 E13112 complement(1080203..1081237) conserved hypothetical protein SAKL0E13134g 0 1081793 1083418 ON 5 E13134 complement(1081793..1083418) highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 karyopherin alpha homolog of 60 kDa SAKL0E13156g 0 1084548 1085111 ON 5 E13156 complement(1084548..1085111) some similarities with uniprot|P53872 Saccharomyces cerevisiae YNL190W Hypothetical ORF SAKL0E13178g 0 1086160 1087313 ON 5 E13178 complement(1086160..1087205,1087289..1087313) highly similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W Hypothetical ORF SAKL0E13200g 0 1087744 1088285 ON 5 E13200 complement(1087744..1088137,1088221..1088285) highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase functions in protein translation may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes SAKL0E13222g 0 1089025 1092135 ON 5 E13222 complement(1089025..1092135) similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I requires activation from zymogenic form in order to catalyze the transfer of N- acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor SAKL0E13244g 0 1092314 1093618 ON 5 E13244 complement(1092314..1093618) similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Hypothetical ORF SAKL0E13266g 1 1094162 1097104 ON 5 E13266 (1094162..1097104) some similarities with uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails regulates telomere replication through recruitment of specific sub-complexes but the essential function is telomere capping SAKL0E13288g 1 1097473 1098390 ON 5 E13288 (1097473..1098390) similar to uniprot|Q07651 Saccharomyces cerevisiae YDL222C FMP45 The authentic non-tagged protein was localized to the mitochondria cell cortex protein not required for growth on nonfermentable carbon sources required for viability in stationary phase SAKL0E13310g 1 1098632 1100923 ON 5 E13310 (1098632..1100923) conserved hypothetical protein SAKL0E13332g 1 1101737 1102663 ON 5 E13332 (1101737..1102663) conserved hypothetical protein SAKL0E13354g 1 1103459 1105474 ON 5 E13354 (1103459..1105474) some similarities with Saccharomyces cerevisiae YDL224C WHI4 and uniprot|P34761 Saccharomyces cerevisiae YNL197C WHI3 SAKL0E13376g 0 1106012 1107718 ON 5 E13376 complement(1106012..1107718) similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM SAKL0E13398g 1 1108486 1109574 ON 5 E13398 (1108486..1109574) weakly similar to uniprot|Q01722 Saccharomyces cerevisiae YNL199C GCR2 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr1p SAKL0E13420g 1 1109754 1110476 ON 5 E13420 (1109754..1110476) similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C SAKL0E13442g 1 1110895 1113387 ON 5 E13442 (1110895..1113387) similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Nuclear protein of unknown function deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C deletion is synthetically lethal with a chitin synthase (CHS1) null mutant SAKL0E13464g 0 1113466 1114335 ON 5 E13464 complement(1113466..1114335) highly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation peroxisomal 2 4-dienoyl-CoA reductase SAKL0E13486g 1 1114651 1115730 ON 5 E13486 (1114651..1115730) similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C GCS1 ADP-ribosylation factor GTPase activating protein SAKL0E13508g 0 1116014 1117084 ON 5 E13508 complement(1116014..1117084) weakly similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc-regulated vacuolar membrane- associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell SAKL0E13530g 1 1117401 1118738 ON 5 E13530 (1117401..1118738) similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105 disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes. SAKL0E13552g 0 1118842 1120101 ON 5 E13552 complement(1118842..1120101) highly similar to uniprot|P40160 YNL207W Saccharomyces cerevisiae RIO2 Protein required for cell viability SAKL0E13574g 0 1120781 1121320 ON 5 E13574 complement(1120781..1121320) no similarity SAKL0E13596g 0 1121868 1122458 ON 5 E13596 complement(1121868..1122458) no similarity SAKL0E13618g 0 1122931 1124772 ON 5 E13618 complement(1122931..1124772) highly similar to uniprot|P40150 Saccharomyces cerevisiae YNL209W SSB2 Ribosome-associated molecular chaperone heat shock protein of HSP70 family proposed to be involved in the folding of newly synthesized polypeptide chains homolog of SSB1 SAKL0E13640g 0 1125081 1126151 ON 5 E13640 complement(1125081..1126151) some similarities with uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing required for chromosome pairing and meiotic recombination SAKL0E13662g 0 1126373 1127380 ON 5 E13662 complement(1126373..1127380) similar to uniprot|P25044 Saccharomyces cerevisiae YDL230W PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo including Fpr3p localized to the cytoplasm and the mitochondria SAKL0E13684g 1 1127611 1130838 ON 5 E13684 (1127611..1130838) similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A a drug which is known to affect intracellular transport Sklu_YGOB_Anc_2.37 0 1130964 1131080 ON 5 Anc_2.37 complement(1130964..1131080) ANNOTATED BY YGOB - SAKL0E13706g 1 1131375 1131638 ON 5 E13706 (1131375..1131638) similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Hypothetical ORF SAKL0E13728g 0 1131721 1134213 ON 5 E13728 complement(1131721..1134213) similar to uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Vacuole import and degradation SAKL0E13750g 1 1134419 1135102 ON 5 E13750 (1134419..1135102) similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C Hypothetical ORF SAKL0E13772g 0 1135168 1135767 ON 5 E13772 complement(1135168..1135767) similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane protein component of the peroxisomal translocation machinery required for peroxisome biogenesis binds Pex14p SAKL0E13794g 0 1136340 1137956 ON 5 E13794 complement(1136340..1137956) some similarities with uniprot|Q07684 Saccharomyces cerevisiae YDL233W Hypothetical ORF SAKL0E13816g 0 1138187 1139032 ON 5 E13816 complement(1138187..1139032) weakly similar to uniprot|Q75E48 Ashbya gossypii ABL178W ABL178Wp and some similarites with YNL215W uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions SAKL0E13838g 1 1139193 1141451 ON 5 E13838 (1139193..1141451) similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective) Ypt1p Ypt31p and Ypt32p (in vitro) involved in vesicle mediated protein trafficking SAKL0E13860g 0 1141665 1143575 ON 5 E13860 complement(1141665..1143575) some similarities with uniprot|P11938 Saccharomyces cerevisiae YNL216W RAP1 DNA-binding protein involved in either activation or repression of transcription depending on binding site context also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure SAKL0E13882g 0 1143934 1144866 ON 5 E13882 complement(1143934..1144866) similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Hypothetical ORF SAKL0E13904g 1 1146920 1147390 ON 5 E13904 (1146920..1147390) similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus SAKL0E13926g 0 1147571 1149223 ON 5 E13926 complement(1147571..1149223) similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome interacts functionally with DNA polymerase delta homolog of human Werner helicase interacting protein (WHIP) SAKL0E13948g 0 1149640 1150566 ON 5 E13948 complement(1149640..1150566) similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p- nitrophenyl phosphate involved in dephosphorylation of histone II-A and casein SAKL0E13970g 1 1150944 1152599 ON 5 E13970 (1150944..1152599) similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 catalyzes the transfer of mannose from Dol-P- Man to lipid-linked oligosaccharides mannosyltransferase SAKL0E13992g 0 1152751 1154052 ON 5 E13992 complement(1152751..1154052) highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase catalyzes the first committed step in the 'de novo' biosynthesis of adenosine SAKL0E14014g 1 1155485 1158004 ON 5 E14014 (1155485..1158004) similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P SAKL0E14058g 0 1158826 1160022 ON 5 E14058 complement(1158826..1160022) similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W Hypothetical ORF SAKL0E14080g 1 1160873 1162303 ON 5 E14080 (1160873..1162303) similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures SAKL0E14102g 0 1162980 1163600 ON 5 E14102 complement(1162980..1163600) highly similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p exhibits intrinsic phosphatase activity affects start site selection in vivo Nuclear zinc-finger motif containing protein. SAKL0E14124g 0 1163816 1165264 ON 5 E14124 complement(1163816..1165264) similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p SAKL0E14146g 1 1165421 1167664 ON 5 E14146 (1165421..1167664) similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C Hypothetical ORF Sklu_5.trna26V 1 1169358 1169431 ON 5 tV-AAC (1169358..1169431) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0E14212g 1 1169895 1172657 ON 5 E14212 (1169895..1172657) similar to uniprot|Q75E63 Ashbya gossypii ABL193C ABL193Cp and some similarites with YNL225C uniprot|P53865 Saccharomyces cerevisiae YNL225C CNM67 chaotic nuclear migration predicted mass is 67kDa Spindle pole body protein involved in nuclear migration SAKL0E14234g 1 1172804 1174840 ON 5 E14234 (1172804..1174840) similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain SAKL0E14256g 1 1175087 1176178 ON 5 E14256 (1175087..1176178) highly similar to uniprot|P23202 Saccharomyces cerevisiae YNL229C URE2 Nitrogen catabolite repression regulator that acts by inhibition of GLN3 transcription in good nitrogen source altered form of Ure2p creates [URE3] prion Sklu_YGOB_MFA1 1 1176933 1177034 ON 5 MFA1 (1176933..1177034) ANNOTATED BY YGOB - SAKL0E14278g 1 1177450 1178535 ON 5 E14278 (1177450..1178535) some similarities with uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation SAKL0E14300g 1 1179188 1180237 ON 5 E14300 (1179188..1180237) highly similar to uniprot|P53860 Saccharomyces cerevisiae YNL231C PDR16 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p localizes to lipid particles and microsomes controls levels of various lipids may regulate lipid synthesis homologous to Pdr17p SAKL0E14322g 0 1180306 1181154 ON 5 E14322 complement(1180306..1181154) similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Subunit of the exosome which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation SAKL0E14344g 0 1181654 1184212 ON 5 E14344 complement(1181654..1184212) similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase localized to the bud neck required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p SAKL0E14366g 0 1184939 1186489 ON 5 E14366 complement(1184939..1186489) similar to uniprot|Q75E71 Ashbya gossypii ABL201W ABL201Wp and some similarites with YNL234W uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p SAKL0E14388g 0 1187853 1190663 ON 5 E14388 complement(1187853..1190663) similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription SAKL0E14410g 1 1191449 1192159 ON 5 E14410 (1191449..1192159) similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W SAKL0E14432g 0 1192175 1193107 ON 5 E14432 complement(1192175..1193107) similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0E14454g 1 1195027 1195881 ON 5 E14454 (1195027..1195881) conserved hypothetical protein SAKL0E14476g 1 1196215 1197264 ON 5 E14476 (1196215..1197264) no similarity SAKL0E14498g 1 1197492 1198220 ON 5 E14498 (1197492..1198220) some similarities with uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA originally isolated as bud-site selection mutant that displays a random budding pattern SAKL0E14520g 0 1198273 1199214 ON 5 E14520 complement(1198273..1199214) similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis overproduction suppresses the sod1 (copper zinc superoxide dismutase) null mutation SAKL0E14542g 1 1199439 1201511 ON 5 E14542 (1199439..1201511) weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Protein of unknown function involved in invasive and pseudohyphal growth SAKL0E14564g 0 1201558 1204242 ON 5 E14564 complement(1201558..1204242) some similarities with uniprot|P36165 YKR089C Saccharomyces cerevisiae STC1 Protein of unknown function found in lipid particles potential Cdc28p substrate SAKL0E14586g 0 1205809 1206033 ON 5 E14586 complement(1205809..1206033) no similarity SAKL0E14608g 1 1206444 1206632 ON 5 E14608 (1206444..1206632) no similarity SAKL0E14630g 1 1206642 1208999 ON 5 E14630 (1206642..1208999) similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth SAKL0E14652g 1 1209396 1210388 ON 5 E14652 (1209396..1210388) some similarities with uniprot|Q12416 Saccharomyces cerevisiae YOR083W WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF) periodically expressed in G1 SAKL0E14674g 1 1211477 1212610 ON 5 E14674 (1211477..1212610) similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W Putative lipase of the peroxisomal matrix transcriptionally activated by Yrm1p along with genes involved in multidrug resistance SAKL0E14696g 1 1212848 1213984 ON 5 E14696 (1212848..1213984) some similarities with uniprot|P32583 Saccharomyces cerevisiae YKR092C SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III nucleolar protein that is immunologically and structurally related to rat Nopp140 a nonribosomal protein of the nucleolus and coiled bodies SAKL0E14718g 1 1214297 1216843 ON 5 E14718 (1214297..1216843) highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2 SAKL0E14740g 0 1216985 1219024 ON 5 E14740 complement(1216985..1219024) similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p) conserved coiled-coil protein involved in chromosome segregation spindle checkpoint activity kinetochore assembly and clustering SAKL0E14762g 1 1219459 1220376 ON 5 E14762 (1219459..1220376) similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase also known as pantoate- beta-alanine ligase required for pantothenic acid biosynthesis deletion causes pantothenic acid auxotrophy homologous to E. coli panC Sklu_YGOB_MFA2 1 1220858 1220959 ON 5 MFA2 (1220858..1220959) ANNOTATED BY YGOB - SAKL0E14784g 1 1221254 1221472 ON 5 E14784 (1221254..1221472) no similarity SAKL0E14806g 1 1222639 1224375 ON 5 E14806 (1222639..1224375) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane SAKL0E14828g 1 1226652 1228430 ON 5 E14828 (1226652..1228430) similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter SAKL0E14850g 1 1229975 1231387 ON 5 E14850 (1229975..1231387) similar to uniprot|Q753M9 Ashbya gossypii AFR283W AFR283Wp and weakly similar to YIL146C uniprot|P40458 Saccharomyces cerevisiae YIL146C ECM37 Non-essential protein of unknown function SAKL0E14872g 1 1231857 1235279 ON 5 E14872 (1231857..1235279) similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators SAKL0E14894g 0 1235488 1236212 ON 5 E14894 complement(1235488..1235866,1236205..1236212) highly similar to uniprot|P61864 Saccharomyces cerevisiae YLR167W RPS31 and highly similar to uniprot|P04838 Saccharomyces cerevisiae YIL148W and highly similar to uniprot|P04838 Saccharomyces cerevisiae YKR094C and highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039C Fusion proteins that are cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin SAKL0E14916g 1 1236762 1242101 ON 5 E14916 (1236762..1242101) similar to uniprot|Q02455 Saccharomyces cerevisiae YKR095W MLP1 Myosin-like protein associated with the nuclear envelope connects the nuclear pore complex with the nuclear interior involved in the Tel1p pathway that controls telomere length involved in the retention of unspliced mRNAs in the nucleus SAKL0E14938g 1 1242645 1244434 ON 5 E14938 (1242645..1242714,1242780..1244434) similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication required for the association of the MCM2-7 complex with replication origins SAKL0E14960g 0 1244456 1245610 ON 5 E14960 complement(1244456..1245610) conserved hypothetical protein SAKL0E14982g 1 1245785 1246129 ON 5 E14982 (1245785..1245822,1245898..1246129) similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose SAKL0E15004g 1 1246544 1250134 ON 5 E15004 (1246544..1250134) similar to uniprot|P36168 Saccharomyces cerevisiae YKR096W Hypothetical ORF SAKL0E15026g 0 1250249 1251121 ON 5 E15026 complement(1250249..1251121) conserved hypothetical protein SAKL0E15048g 1 1251927 1253555 ON 5 E15048 (1251927..1253555) highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase key enzyme in gluconeogenesis catalyzes early reaction in carbohydrate biosynthesis glucose represses transcription and accelerates mRNA degradation regulated by Mcm1p and Cat8p located in the cytosol SAKL0E15070g 0 1253760 1254917 ON 5 E15070 complement(1253760..1254917) similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Resistant to Rapamycin Deletion SAKL0E15092g 1 1255185 1256243 ON 5 E15092 (1255185..1256243) some similarities with uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants contains a C-terminal leucine-rich repeat SAKL0E15114g 1 1256624 1258573 ON 5 E15114 (1256624..1258573) highly similar to gnl|GLV|KLLA0A00418g Kluyveromyces lactis KLLA0A00418g and similar to YIL155C uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p Rsf1p Hap2/3/4/5 complex dependent manner SAKL0E15136g 0 1258870 1261983 ON 5 E15136 complement(1258870..1261983) uniprot|Q875P1 Saccharomyces kluyveri UBP7 SAKL0E15158g 1 1263977 1266277 ON 5 E15158 (1263977..1266277) weakly similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways Sklu_YGOB_YIL156W-B 0 1266385 1266674 ON 5 YIL156W-B complement(1266385..1266597,1266666..1266674) ANNOTATED BY YGOB - SAKL0E15180g 1 1266823 1267362 ON 5 E15180 (1266823..1267362) similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C FMP35 The authentic non-tagged protein was localized to the mitochondria SAKL0E15202g 0 1267463 1268437 ON 5 E15202 complement(1267463..1268437) similar to uniprot|P36169 Saccharomyces cerevisiae YKR100C SKG1 Protein of unknown function and similar to uniprot|P40451 Saccharomyces cerevisiae YIL158w SAKL0E15224g 0 1269114 1273121 ON 5 E15224 complement(1269114..1273121) some similarities with uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNI1 SAKL0E15246g 1 1274266 1275489 ON 5 E15246 (1274266..1275489) similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids SAKL0E15268g 0 1275498 1276172 ON 5 E15268 complement(1275498..1276172) some similarities with uniprot|P40449 Saccharomyces cerevisiae YIL161W Hypothetical ORF SAKL0E15290g 0 1277008 1278606 ON 5 E15290 complement(1277008..1278606) similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph SAKL0E15312g 1 1279904 1281559 ON 5 E15312 (1279904..1281559) similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase SAKL0E15356g 1 1283552 1285225 ON 5 E15356 (1283552..1285225) weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. SAKL0E15378g 1 1287766 1291167 ON 5 E15378 (1287766..1291167) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W SAKL0E15422g 0 1294134 1294358 ON 5 E15422 complement(1294134..1294358) no similarity SAKL0F00110g 1 1456 3318 ON 6 F00110 (1456..3318) similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C SAKL0F00132g 1 4220 5524 ON 6 F00132 (4220..5524) similar to uniprot|Q96W94 Saccharomyces kluyveri PYD3 Beta-alanine synthase SAKL0F00176g 0 7651 8010 ON 6 F00176 complement(7651..8010) no similarity SAKL0F00198g 0 10713 12326 ON 6 F00198 complement(10713..12326) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF SAKL0F00242g 1 16275 17150 ON 6 F00242 (16275..17150) similar to gnl|GLV|KLLA0A10373g Kluyveromyces lactis KLLA0A10373g and weakly similar to YGL254W uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism sole identified regulatory target is SSU1 overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1 contains five zinc fingers SAKL0F00286g 0 20208 22076 ON 6 F00286 complement(20208..22076) similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport SAKL0F00308g 1 23531 25120 ON 6 F00308 (23531..25120) conserved hypothetical protein SAKL0F00330g 0 27045 28763 ON 6 F00330 complement(27045..28763) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0F00352g 0 28893 29165 ON 6 F00352 complement(28893..29165) no similarity SAKL0F00374g 0 30356 30730 ON 6 F00374 complement(30356..30730) no similarity SAKL0F00396g 1 31629 33212 ON 6 F00396 (31629..33212) highly similar to gnl|GLV|KLLA0D16412g Kluyveromyces lactis KLLA0D16412g and similar to YJL153C uniprot|P11986 Saccharomyces cerevisiae YJL153C INO1 Inositol 1- phosphate synthase involved in synthesis of inositol phosphates and inositol-containing phospholipids transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p which bind the UASINO DNA element SAKL0F00418g 1 34751 36430 ON 6 F00418 (34751..36430) conserved hypothetical protein SAKL0F00440g 0 36452 38086 ON 6 F00440 complement(36452..38086) conserved hypothetical protein SAKL0F00462g 1 41362 42816 ON 6 F00462 (41362..42816) highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W HXK2 Hexokinase isoenzyme 2 catalyzes phosphorylation of glucose in the cytosol predominate hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene SAKL0F00484g 0 43540 44337 ON 6 F00484 complement(43540..44337) similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1 which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p SAKL0F00506g 0 44668 46419 ON 6 F00506 complement(44668..46419) highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction regulates the subcellular location of Rtg1p and Rtg3p transcriptional activators of the retrograde (RTG) and TOR pathways Rtg2p is inhibited by the phosphorylated form of Mks1p SAKL0F00528g 0 46584 50141 ON 6 F00528 complement(46584..50141) similar to uniprot|P51979 Saccharomyces cerevisiae YGL251C HFM1 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control catalyzes the unwinding of Holliday junctions has ssDNA and dsDNA stimulated ATPase activity SAKL0F00550g 1 50690 51877 ON 6 F00550 (50690..51877) similar to uniprot|P53060 Saccharomyces cerevisiae YGL250W Hypothetical ORF SAKL0F00572g 1 52091 54337 ON 6 F00572 (52091..54337) some similarities with uniprot|P53061 Saccharomyces cerevisiae YGL249W ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis involved in meiotic recombination and disjunction SAKL0F00594g 1 54485 56122 ON 6 F00594 (54485..56122) similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER SAKL0F00616g 1 56334 57131 ON 6 F00616 (56334..57131) highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 20S proteasome beta-type subunit SAKL0F00638g 1 57892 58986 ON 6 F00638 (57892..58986) similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase controls glucose and intracellular acidification-induced cAMP signaling target of the cAMP-protein kinase A (PKA) pathway glucose induces transcription and inhibits translation SAKL0F00660g 0 59107 59490 ON 6 F00660 complement(59107..59490) similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W SAKL0F00682g 1 59899 60450 ON 6 F00682 (59899..60450) weakly similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport depletion alters nucleoporin distribution and nuclear envelope morphology suggesting a role in the spatial organization of nuclear pores SAKL0F00704g 1 60941 61888 ON 6 F00704 (60941..61888) similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters SAKL0F00726g 0 63291 64442 ON 6 F00726 complement(63291..64442) highly similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing SAKL0F00748g 1 64800 66923 ON 6 F00748 (64800..66923) highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS) forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm SAKL0F00770g 0 66976 68886 ON 6 F00770 complement(66976..68886) similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation SAKL0F00792g 1 70444 72297 ON 6 F00792 (70444..72297) similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores SAKL0F00814g 1 72843 74567 ON 6 F00814 (72843..74567) similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements SAKL0F00836g 1 74958 76109 ON 6 F00836 (74958..76109) similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase deaminates adenosine-37 to inosine in tRNA-Ala SAKL0F00858g 0 76158 76679 ON 6 F00858 complement(76158..76679) similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Hypothetical ORF SAKL0F00880g 1 76850 79879 ON 6 F00880 (76850..79879) similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W SAKL0F00902g 1 80022 81544 ON 6 F00902 (80022..80139,80193..81544) conserved hypothetical protein SAKL0F00924g 1 82378 83265 ON 6 F00924 (82378..83265) highly similar to uniprot|P43619 Saccharomyces cerevisiae YFR047C BNA6 Quinolinate phosphoribosyl transferase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway SAKL0F00946g 1 83404 84156 ON 6 F00946 (83404..84156) similar to uniprot|Q753P0 Ashbya gossypii AFR272W AFR272Wp and weakly similar to YGL240W uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC) mediates the activity of the APC by contributing to substrate recognition involved in cyclin proteolysis SAKL0F00968g 1 84333 87218 ON 6 F00968 (84333..87218) highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) homolog of metazoan CAS protein required for accurate chromosome segregation SAKL0F00990g 0 87334 88137 ON 6 F00990 complement(87334..88137) some similarities with uniprot|P06774 Saccharomyces cerevisiae YGL237C HAP2 Subunit of the heme-activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences sufficient for both complex assembly and DNA binding SAKL0F01012g 1 88346 89407 ON 6 F01012 (88346..89407) weakly similar to uniprot|P43618 Saccharomyces cerevisiae YFR046C CNN1 Kinetochore protein that co- purifies with Nnf1p SAKL0F01034g 0 89540 91591 ON 6 F01034 complement(89540..91591) highly similar to gnl|GLV|KLLA0A00935g Kluyveromyces lactis KLLA0A00935g and similar to YGL236C uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis SAKL0F01056g 1 92596 94986 ON 6 F01056 (92596..94986) highly similar to uniprot|Q9HG45 Kluyveromyces lactis Purine biosynthetic pathway protein ADE5,7 and to YGL234W uniprot|P07244 Saccharomyces cerevisiae YGL234W ADE5 7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities SAKL0F01078g 0 95066 96168 ON 6 F01078 complement(95066..96055,96133..96168) some similarities with uniprot|P43617 Saccharomyces cerevisiae YFR045W Hypothetical ORF SAKL0F01100g 1 96415 97923 ON 6 F01100 (96415..97923) highly similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C Hypothetical ORF SAKL0F01122g 0 97966 99585 ON 6 F01122 complement(97966..99585) similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 Sklu_6.trna1D 1 100509 100580 ON 6 tD-GUC (100509..100580) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0F01166g 1 100915 103569 ON 6 F01166 (100915..103569) similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which mediates polarized targeting of vesicles to active sites of exocytosis Sec15p associates with Sec4p and vesicles SAKL0F01188g 1 104191 105106 ON 6 F01188 (104191..104238,104303..105106) similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA SAKL0F01210g 0 105198 105743 ON 6 F01210 complement(105198..105743) similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C Hypothetical ORF SAKL0F01232g 0 105967 106500 ON 6 F01232 complement(105967..106500) no similarity SAKL0F01254g 1 106788 107540 ON 6 F01254 (106788..107540) similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C Hypothetical ORF SAKL0F01276g 0 107568 108200 ON 6 F01276 complement(107568..108200) similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W Protein required for cell viability SAKL0F01298g 1 108332 109231 ON 6 F01298 (108332..109231) similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Endoplasmic reticulum protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain SAKL0F01320g 0 109422 112166 ON 6 F01320 complement(109422..112166) similar to uniprot|P43612 Saccharomyces cerevisiae YFR040W SAKL0F01342g 1 112464 114347 ON 6 F01342 (112464..114347) similar to uniprot|Q753T2 Ashbya gossypii AFR244C AFR244Cp and some similarites with YGL228W uniprot|P53075 Saccharomyces cerevisiae YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function overexpression causes growth arrest SAKL0F01364g 1 114822 116171 ON 6 F01364 (114822..116171) highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S- adenosyl-L-methionine (AdoMet) to an acceptor SAKL0F01386g 1 117250 119826 ON 6 F01386 (117250..119826) similar to uniprot|Q753T4 Ashbya gossypii AFR242C AFR242Cp and weakly similar to YGL227W uniprot|P53076 Saccharomyces cerevisiae SAKL0F01408g 0 119882 120218 ON 6 F01408 complement(119882..120124,120198..120218) similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins SAKL0F01430g 1 120439 120882 ON 6 F01430 (120439..120882) similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W Hypothetical ORF SAKL0F01452g 0 120931 121485 ON 6 F01452 complement(120931..121485) highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Peptide methionine sulfoxide reductase reverses the oxidation of methionine residues involved in oxidative damage repair providing resistance to oxidative stress and regulation of lifespan SAKL0F01474g 0 121664 124027 ON 6 F01474 complement(121664..124027) similar to uniprot|P40028 Saccharomyces cerevisiae YER041W YEN1 Protein of unknown function has similarity to endonuclease Rth1p potentially phosphorylated by Cdc28p SAKL0F01496g 0 124251 126668 ON 6 F01496 complement(124251..126668) some similarities with uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) localization and activity regulated by quality of nitrogen source SAKL0F01518g 1 127471 128487 ON 6 F01518 (127471..128487) highly similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W VRG4 May regulate Golgi function and glycosylation in Golgi Golgi GDP-mannose transporter SAKL0F01540g 1 128878 130182 ON 6 F01540 (128878..130182) similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance SAKL0F01562g 0 130218 131120 ON 6 F01562 complement(130218..131120) similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C SDT1 Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II as well as resistance to other pyrimidine derivatives or to YER037W uniprot|P40025 Saccharomyces cerevisiae YER037W PHM8 SAKL0F01584g 0 131250 132683 ON 6 F01584 complement(131250..132683) weakly similar to uniprot|P53079 Saccharomyces cerevisiae YGL223C COG1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments SAKL0F01606g 1 133318 135144 ON 6 F01606 (133318..135144) highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C SAKL0F01628g 0 135919 136998 ON 6 F01628 complement(135919..136998) weakly similar to uniprot|P53080 Saccharomyces cerevisiae YGL222C EDC1 RNA-binding protein activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p SAKL0F01650g 0 137138 137665 ON 6 F01650 complement(137138..137665) similar to uniprot|P40022 Saccharomyces cerevisiae YER034W Hypothetical ORF SAKL0F01672g 0 137750 138610 ON 6 F01672 complement(137750..138610) highly similar to gnl|GLV|KLLA0A01518g Kluyveromyces lactis KLLA0A01518g and similar to YGL221C uniprot|P53081 Saccharomyces cerevisiae SAKL0F01694g 1 138816 139070 ON 6 F01694 (138816..139070) similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W Hypothetical ORF SAKL0F01716g 0 141145 142800 ON 6 F01716 complement(141145..142800) similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial outer membrane protein colocalizes with mtDNA nucleids required for mitochondria shape SAKL0F01738g 1 143208 145064 ON 6 F01738 (143208..145064) conserved hypothetical protein SAKL0F01760g 1 146659 149088 ON 6 F01760 (146659..149088) similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning SAKL0F01782g 1 149755 150963 ON 6 F01782 (149755..150963) some similarities with uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography cyclin-like protein that interacts with Pho85 SAKL0F01804g 0 151476 152790 ON 6 F01804 complement(151476..152714,152788..152790) similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 essential for protection against viral cytopathology dispensable for mitotic but required for meiotic recombination and spore viability antiviral protein mRNA is induced early in meiosis SAKL0F01826g 1 153006 154055 ON 6 F01826 (153006..154055) similar to uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Regulator of vacuolar morphogenesis hydrophilic protein heptad repeat motif SAKL0F01848g 1 154310 155434 ON 6 F01848 (154310..155434) similar to uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0F01870g 1 155998 158592 ON 6 F01870 (155998..158592) some similarities with uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency SAKL0F01892g 0 158750 161728 ON 6 F01892 complement(158750..161728) some similarities with uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing interacts with Ref2p potential Cdc28p substrate SAKL0F01914g 1 162387 163246 ON 6 F01914 (162387..162432,162627..163246) highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment ras-like GTPase highly homologous to YPT31 SAKL0F01936g 0 163474 163917 ON 6 F01936 complement(163474..163917) no similarity SAKL0F01958g 1 164784 165287 ON 6 F01958 (164784..165287) similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein SAKL0F01980g 1 165916 167073 ON 6 F01980 (165916..167073) some similarities with uniprot|P53035 Saccharomyces cerevisiae YGL209W MIG2 Protein containing zinc fingers involved in repression along with Mig1p of SUC2 (invertase) expression by high levels of glucose binds to Mig1p-binding sites in SUC2 promoter SAKL0F02002g 1 167591 169102 ON 6 F02002 (167591..169102) similar to gnl|GLV|CAGL0A03696g Candida glabrata CAGL0A03696g and similar to YER027C uniprot|Q04739 Saccharomyces cerevisiae YER027C GAL83 One of three possible beta-subunits of the Snf1 kinase complex allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source contains glycogen-binding domain and similar to YGL208W uniprot|P34164 Saccharomyces cerevisiae YGL208W SIP2 Member of a family of proteins including Sip1p and Gal83p that interact with Snf1p and Snf4p and are involved in the response to glucose starvation component of Snf1 protein complex involved in response to glucose starvation SAKL0F02024g 1 169409 172513 ON 6 F02024 (169409..172513) highly similar to uniprot|P32558 Saccharomyces cerevisiae YGL207W SPT16 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure SAKL0F02046g 0 172863 177842 ON 6 F02046 complement(172863..177842) highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 vesicle coat protein presumed vesicle coat protein SAKL0F02068g 1 178313 180562 ON 6 F02068 (178313..180562) similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase involved in the fatty acid beta-oxidation pathway localized to the peroxisomal matrix SAKL0F02090g 1 180908 181723 ON 6 F02090 (180908..181723) highly similar to uniprot|Q756B0 Ashbya gossypii AER357C AER357Cp and similar to YER026C uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 phosphatidylserine synthase Sklu_6.trna2H 0 182016 182087 ON 6 tH-GUG complement(182016..182087) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 SAKL0F02134g 0 182707 184788 ON 6 F02134 complement(182707..184788) similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor cleaves Lys and Arg residues from the C-terminus of peptides and proteins SAKL0F02156g 1 185574 187070 ON 6 F02156 (185574..187070) highly similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis SAKL0F02178g 0 187479 189050 ON 6 F02178 complement(187479..189050) weakly similar to uniprot|P36035 Saccharomyces cerevisiae YKL217w SAKL0F02200g 0 189286 189828 ON 6 F02200 complement(189286..189828) no similarity SAKL0F02222g 0 189904 192651 ON 6 F02222 complement(189904..192651) highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen activity is regulated by cyclic AMP-mediated phosphorylation expression is regulated by stress-response elements and by the HOG MAP kinase pathway SAKL0F02244g 0 193425 196550 ON 6 F02244 complement(193425..196550) similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Sklu_6.trna3G 0 196892 196962 ON 6 tG-GCC complement(196892..196962) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0F02310g 0 198818 200923 ON 6 F02310 complement(198818..200923) similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p SAKL0F02332g 0 202070 202972 ON 6 F02332 complement(202070..202972) conserved hypothetical protein Sklu_6.trna4A 0 203508 203580 ON 6 tA-AGC complement(203508..203580) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0F02376g 0 204487 205716 ON 6 F02376 complement(204487..205716) similar to uniprot|P53286 Saccharomyces cerevisiae YGR142W BTN2 Cytosolic coiled-coil protein that modulates arginine uptake interacts with Rhb1p possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase may have a role in intracellular protein trafficking SAKL0F02398g 0 206428 207771 ON 6 F02398 complement(206428..207771) similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W VPS62 and similar to uniprot|Q06466 Saccharomyces cerevisiae YPR157W Hypothetical ORF SAKL0F02420g 0 208358 210985 ON 6 F02420 complement(208358..210985) similar to uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere Cbf2p also binds to the CDEII region possibly forming a different multimeric complex ubiquitinated in vivo SAKL0F02442g 1 211990 213822 ON 6 F02442 (211990..213822) highly similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C TPO2 Polyamine transport protein SAKL0F02464g 1 214347 216227 ON 6 F02464 (214347..216227) similar to uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase functions with Nca3p SAKL0F02486g 0 216399 217091 ON 6 F02486 complement(216399..217091) similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced SAKL0F02508g 0 217712 218277 ON 6 F02508 complement(217712..217835,217912..218205,218273..218277) similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Hypothetical ORF SAKL0F02530g 0 218391 219149 ON 6 F02530 complement(218391..219149) highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 20S proteasome beta-type subunit the only nonessential 20S subunit SAKL0F02552g 1 219380 220816 ON 6 F02552 (219380..220816) similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C Hypothetical ORF SAKL0F02574g 0 220827 221696 ON 6 F02574 complement(220827..221696) similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W SAKL0F02596g 0 221983 225381 ON 6 F02596 complement(221983..225381) similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily-conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation SAKL0F02618g 1 225795 226556 ON 6 F02618 (225795..226556) similar to uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c SAKL0F02640g 0 227067 227417 ON 6 F02640 complement(227067..227417) some similarities with uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria SAKL0F02684g 0 228156 228572 ON 6 F02684 complement(228156..228572) conserved hypothetical protein SAKL0F02706g 0 229712 230197 ON 6 F02706 complement(229712..230197) similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Involved in peroxisome biogenesis Member of ubiquitin-conjugating protein family SAKL0F02728g 1 231020 231868 ON 6 F02728 (231020..231868) highly similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C SAKL0F02750g 0 232715 233227 ON 6 F02750 complement(232715..233227) similar to uniprot|Q12207 Saccharomyces cerevisiae YPR149W NCE102 and to uniprot|P53279 Saccharomyces cerevisiae YGR131W SAKL0F02772g 1 234381 236702 ON 6 F02772 (234381..236702) similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0F02794g 1 238272 239465 ON 6 F02794 (238272..239465) similar to uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0F02816g 0 239471 240049 ON 6 F02816 complement(239471..240049) weakly similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 SYnthetic lethal with cdcForty (putative) involved in pre-mRNA splicing SAKL0F02838g 1 240272 242236 ON 6 F02838 (240272..242236) similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0F02860g 1 242683 243600 ON 6 F02860 (242683..243600) similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147C Hypothetical ORF SAKL0F02882g 0 243632 244528 ON 6 F02882 complement(243632..244528) similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Hypothetical ORF SAKL0F02904g 0 244726 245394 ON 6 F02904 complement(244726..245394) similar to gnl|GLV|CAGL0I10604g Candida glabrata CAGL0I10604g and weakly similar to YGR126W uniprot|P53274 Saccharomyces cerevisiae YGR126W Hypothetical ORF SAKL0F02926g 0 245957 249109 ON 6 F02926 complement(245957..249109) similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Hypothetical ORF SAKL0F02948g 1 251364 251885 ON 6 F02948 (251364..251885) no similarity SAKL0F02970g 0 252336 254057 ON 6 F02970 complement(252336..254057) highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L- aspartate in the asparagine biosynthetic pathway SAKL0F03014g 1 255267 256868 ON 6 F03014 (255267..256868) similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Sklu_6.trna5I 0 257363 257436 ON 6 tI-AAU complement(257363..257436) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0F03102g 1 258266 259807 ON 6 F03102 (258266..259807) highly similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C Sklu_6.trna6R 0 260021 260092 ON 6 tR-UCU complement(260021..260092) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0F03146g 0 260272 261081 ON 6 F03146 complement(260272..261081) some similarities with uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre- rRNA processing SAKL0F03168g 1 261405 263525 ON 6 F03168 (261405..263525) similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate SAKL0F03190g 1 263811 264269 ON 6 F03190 (263811..264269) conserved hypothetical protein SAKL0F03212g 0 264414 265601 ON 6 F03212 complement(264414..265601) similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W SAKL0F03234g 1 265806 266732 ON 6 F03234 (265806..266732) similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66 SAKL0F03256g 0 266857 268311 ON 6 F03256 complement(266857..268311) similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W Hypothetical ORF SAKL0F03278g 1 268689 270104 ON 6 F03278 (268689..270104) similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4 ) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1 Sklu_6.trna7N 0 270448 270521 ON 6 tN-GUU complement(270448..270521) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 Sklu_6.trna8H 1 272375 272446 ON 6 tH-GUG (272375..272446) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 SAKL0F03410g 1 272918 273889 ON 6 F03410 (272918..273889) no similarity SAKL0F03432g 0 274302 276029 ON 6 F03432 complement(274302..276029) similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Rrp9p is an ortholog of the human U3-55k protein the human cDNA partially complements a yeast rrp9 null mutant. (Pluk et al. (1998) Mol. Cell. Biol. 18 488-498.) U3 small nucleolar ribonucleoprotein-associated protein involved in pre- ribosomal RNA processing. SAKL0F03454g 0 276270 279071 ON 6 F03454 complement(276270..279071) similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion SAKL0F03476g 1 279635 280462 ON 6 F03476 (279635..280462) similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments SAKL0F03498g 1 280671 282269 ON 6 F03498 (280671..282269) some similarities with uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC) SAKL0F03520g 0 282380 283267 ON 6 F03520 complement(282380..283267) weakly similar to uniprot|P08593 Saccharomyces cerevisiae YPR134W MSS18 Protein involved in splicing intron a15beta of COX1 Involved in splicing of mitochondrial COX1 transcript SAKL0F03542g 0 283485 283637 ON 6 F03542 complement(283485..283637) similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria SAKL0F03564g 1 283855 284913 ON 6 F03564 (283855..284913) similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt- phenotype SAKL0F03586g 0 285147 286001 ON 6 F03586 complement(285147..285519,285937..286001) uniprot|Q875Q2 Saccharomyces kluyveri RPS23 SAKL0F03608g 1 286624 288084 ON 6 F03608 (286624..288084) similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C Hypothetical ORF SAKL0F03630g 1 288875 289492 ON 6 F03630 (288875..289492) highly similar to gnl|GLV|CAGL0D04796g Candida glabrata CAGL0D04796g and similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met SAKL0F03652g 0 289608 290420 ON 6 F03652 complement(289608..290420) similar to uniprot|Q75A81 Ashbya gossypii ADR037W ADR037Wp and weakly similar to YPR129W uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin SAKL0F03674g 1 290851 291885 ON 6 F03674 (290851..291885) similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation SAKL0F03696g 0 292000 293034 ON 6 F03696 complement(292000..293034) similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Hypothetical ORF SAKL0F03718g 0 294662 295975 ON 6 F03718 complement(294662..295975) similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W Hypothetical ORF SAKL0F03740g 0 296563 297912 ON 6 F03740 complement(296563..297912) some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3- phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A SAKL0F03762g 0 298615 303000 ON 6 F03762 complement(298615..303000) similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation SAKL0F03784g 0 303600 304628 ON 6 F03784 complement(303600..304628) similar to gnl|GLV|KLLA0B11407g Kluyveromyces lactis KLLA0B11407g and weakly similar to YPR124W uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High- affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels SAKL0F03806g 0 304826 305746 ON 6 F03806 complement(304826..305746) similar to gnl|GLV|KLLA0B11429g Kluyveromyces lactis KLLA0B11429g and weakly similar to YGR113W uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore- microtubule attachments SAKL0F03828g 0 305948 307018 ON 6 F03828 complement(305948..307018) similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W SAKL0F03850g 0 307483 308427 ON 6 F03850 complement(307483..308427) highly similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit SAKL0F03872g 0 309740 310432 ON 6 F03872 complement(309740..310432) similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity SAKL0F03894g 1 312042 314270 ON 6 F03894 (312042..314270) similar to uniprot|P39925 Saccharomyces cerevisiae YER017C AFG3 Component with Yta12p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes SAKL0F03916g 0 314525 315532 ON 6 F03916 complement(314525..315532) similar to uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally SAKL0F03938g 1 315509 316945 ON 6 F03938 (315509..316945) conserved hypothetical protein SAKL0F03960g 0 317042 319306 ON 6 F03960 complement(317042..319306) similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids SAKL0F03982g 0 319563 319895 ON 6 F03982 complement(319563..319895) similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members SAKL0F04004g 0 320342 321943 ON 6 F04004 complement(320342..321943) similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX SAKL0F04026g 0 322105 325524 ON 6 F04026 complement(322105..325524) similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing SAKL0F04048g 0 325816 326400 ON 6 F04048 complement(325816..326400) similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle SAKL0F04070g 1 326657 327979 ON 6 F04070 (326657..327979) highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair SAKL0F04092g 0 328089 330389 ON 6 F04092 complement(328089..330389) similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Hypothetical ORF Sklu_6.trna9E 0 330595 330666 ON 6 tE-UUC complement(330595..330666) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0F04158g 0 331544 333298 ON 6 F04158 complement(331544..333298) similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology Sklu_YGOB_Anc_7.117 1 333528 334202 ON 6 Anc_7.117 (333528..334202) ANNOTATED BY YGOB - SAKL0F04180g 1 334325 334810 ON 6 F04180 (334325..334810) similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits SAKL0F04202g 0 334930 335376 ON 6 F04202 complement(334930..335376) some similarities with uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta- barrel proteins also proposed to be involved in mitochondrial import SAKL0F04224g 1 335860 336690 ON 6 F04224 (335860..335894,335967..336690) highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit SAKL0F04246g 1 337116 339596 ON 6 F04246 (337116..339596) some similarities with uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate SAKL0F04268g 0 339908 340759 ON 6 F04268 complement(339908..340759) weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism Sklu_6.trna10T 1 341217 341289 ON 6 tT-AGU (341217..341289) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 72.63 SAKL0F04312g 0 342711 346727 ON 6 F04312 complement(342711..346727) similar to uniprot|Q08409 Saccharomyces cerevisiae YOR011W AUS1 Transporter of the ATP-binding cassette family involved in uptake of sterols and anaerobic growth SAKL0F04334g 0 347639 349333 ON 6 F04334 complement(347639..349333) uniprot|Q6XAE9 Saccharomyces kluyveri PDC13 Pyruvate decarboxylase SAKL0F04356g 1 349995 350690 ON 6 F04356 (349995..350690) some similarities with uniprot|P40552 Saccharomyces cerevisiae YIL011W TIR3 Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins expressed under anaerobic conditions and required for anaerobic growth SAKL0F04378g 1 351154 355491 ON 6 F04378 (351154..355491) weakly similar to uniprot|P32521 YIR006C Saccharomyces cerevisiae PAN1 Part of actin cytoskeleton- regulatory complex Pan1p-Sla1p-End3p SAKL0F04400g 0 355542 356108 ON 6 F04400 complement(355542..356108) similar to uniprot|P40565 YIR005W Saccharomyces cerevisiae IST3 Component of the U2 snRNP required for the first catalytic step of splicing and for spliceosomal assembly SAKL0F04422g 1 356328 357038 ON 6 F04422 (356328..357038) similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Hypothetical ORF SAKL0F04444g 0 357126 358415 ON 6 F04444 complement(357126..358415) similar to uniprot|P40564 YIR004W Saccharomyces cerevisiae DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import SAKL0F04466g 0 358639 360387 ON 6 F04466 complement(358639..360387) some similarities with uniprot|P40563 Saccharomyces cerevisiae YIR003W Hypothetical ORF SAKL0F04488g 0 360925 361302 ON 6 F04488 complement(360925..361302) highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport SAKL0F04510g 1 361528 365280 ON 6 F04510 (361528..365280) similar to uniprot|P33332 YER008C Saccharomyces cerevisiae SEC3 Non-essential subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p Exo84p) SAKL0F04532g 1 365436 368558 ON 6 F04532 (365436..368558) similar to uniprot|P40562 YIR002C Saccharomyces cerevisiae MPH1 Member of the DEAH family of helicases SAKL0F04576g 1 369113 370121 ON 6 F04576 (369113..369120,369587..370121) similar to uniprot|P89886 Saccharomyces cerevisiae YER007C-A TMA20 Protein of unknown function that associates with ribosomes SAKL0F04598g 0 370167 371651 ON 6 F04598 complement(370167..371651) similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation binds alpha-tubulin required for normal microtubule function null mutant exhibits cold- sensitive microtubules and sensitivity to benomyl SAKL0F04620g 0 372206 373786 ON 6 F04620 complement(372206..373786) highly similar to gnl|GLV|KLLA0D13618g Kluyveromyces lactis KLLA0D13618g and similar to YER006W uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre-ribosomes required for export of 60S ribosomal subunits from the nucleus SAKL0F04642g 1 374168 375247 ON 6 F04642 (374168..375247) highly similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB a general transcription factor required for transcription initiation and start site selection by RNA polymerase II SAKL0F04664g 0 375457 377424 ON 6 F04664 complement(375457..377424) similar to uniprot|P40009 YER005W Saccharomyces cerevisiae YND1 Yeast Nucleoside Diphosphatase SAKL0F04686g 0 377594 378265 ON 6 F04686 complement(377594..378265) similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria SAKL0F04708g 0 378356 378949 ON 6 F04708 complement(378356..378949) conserved hypothetical protein SAKL0F04730g 1 379103 380489 ON 6 F04730 (379103..379133,379231..380489) highly similar to uniprot|P29952 YER003C Saccharomyces cerevisiae PMI40 mannose-6-phosphate isomerase SAKL0F04752g 0 380727 381428 ON 6 F04752 complement(380727..381428) similar to uniprot|P40007 YER002W Saccharomyces cerevisiae NOP16 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis SAKL0F04774g 1 381688 382542 ON 6 F04774 (381688..382542) similar to gnl|GLV|CAGL0J02200g Candida glabrata CAGL0J02200g and some similarites with YIR001C uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA- binding protein contains an RNA recognition motif (RRM) may have a role in mRNA translation as suggested by genetic interactions with genes encoding proteins involved in translational initiation Sklu_CEN6 0 383110 383306 ON 6 CEN6 complement(383110..383306) Chromosome VI centromere SAKL0F04818g 1 383824 384471 ON 6 F04818 (383824..384471) similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C Hypothetical ORF SAKL0F04840g 0 384579 386138 ON 6 F04840 complement(384579..386138) similar to uniprot|P40560 YIL001W Saccharomyces cerevisiae Hypothetical ORF SAKL0F04862g 1 388124 390952 ON 6 F04862 (388124..390952) similar to uniprot|P40559 YIL002C Saccharomyces cerevisiae INP51 Phosphatidylinositol 4 5-bisphosphate 5- phosphatase Sklu_YGOB_Anc_7.141 0 391019 391231 ON 6 Anc_7.141 complement(391019..391231) ANNOTATED BY YGOB - SAKL0F04884g 1 391383 392693 ON 6 F04884 (391383..392693) similar to uniprot|P33767 YEL002C Saccharomyces cerevisiae WBP1 wheat germ agglutinin-binding protein oligosaccharyl transferase glycoprotein complex beta subunit SAKL0F04906g 0 392819 393221 ON 6 F04906 complement(392819..393135,393197..393221) similar to uniprot|P40005 Saccharomyces cerevisiae YEL003W GIM4 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it SAKL0F04928g 0 393375 394466 ON 6 F04928 complement(393375..394466) similar to uniprot|P40004 Saccharomyces cerevisiae YEL004W SAKL0F04950g 1 395022 396191 ON 6 F04950 (395022..396191) some similarities with uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function as suggested by its ability to bind Vac8p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0F04972g 0 396225 397121 ON 6 F04972 complement(396225..397121) similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm has a potential role in assembly of iron-sulfur clusters in proteins SAKL0F04994g 1 397257 397751 ON 6 F04994 (397257..397267,397340..397751) highly similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C BET1 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins SAKL0F05016g 0 397906 400050 ON 6 F05016 complement(397906..400050) similar to uniprot|P40557 YIL005W Saccharomyces cerevisiae EPS1 protein disulfide isomerase related protein involved in endoplasmic reticulum retention of resident ER proteins SAKL0F05038g 0 400575 401741 ON 6 F05038 complement(400575..401741) similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W Pvruvate transporter of the mitochondrial inner membrane member of the mitochondrial carrier family has putative mouse and human orthologs SAKL0F05060g 0 402603 404012 ON 6 F05060 complement(402603..404012) some similarities with uniprot|P40002 Saccharomyces cerevisiae YEL007W Hypothetical ORF and some similarities with YHR177W uniprot|P38867 Saccharomyces cerevisiae YHR177W SAKL0F05082g 1 406484 407344 ON 6 F05082 (406484..407344) similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels SAKL0F05104g 1 408002 408791 ON 6 F05104 (408002..408451,408576..408791) similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C NAS2 Protein with similarity to the p27 subunit of mammalian proteasome modulator SAKL0F05126g 0 408866 409171 ON 6 F05126 complement(408866..409171) highly similar to uniprot|P40554 YIL008W Saccharomyces cerevisiae URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin Sklu_6.trna11R 1 409374 409445 ON 6 tR-UCU (409374..409445) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0F05170g 1 409898 411628 ON 6 F05170 (409898..411628) similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2- isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway Sklu_6.trna12W 0 411773 411876 ON 6 tW-CCA complement(411773..411808,411841..411876) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 65.49 Sklu_6.trna13D 1 412889 412960 ON 6 tD-GUC (412889..412960) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 Sklu_YGOB_Anc_7.128 1 413034 413330 OFF 6 Anc_7.128 (413034..413330) ANNOTATED BY YGOB - Sklu_YGOB_EST3 1 413034 413625 ON 6 EST3 (413034..413324,413326..413625) ANNOTATED BY YGOB - Ribosomal frameshifting (Farabaugh, J Mol Evol 63:545, 2006) SAKL0F05346g 1 413830 415173 ON 6 F05346 (413830..415173) highly similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 medium subunit of the clathrin- associated protein complex SAKL0F05368g 0 415292 415987 ON 6 F05368 complement(415292..415987) highly similar to gnl|GLV|KLLA0D14333g Kluyveromyces lactis KLLA0D14333g and similar to YIL010W uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase SAKL0F05390g 0 416314 418101 ON 6 F05390 complement(416314..418101) highly similar to gnl|GLV|CAGL0H09108g Candida glabrata CAGL0H09108g and similar to Q08977 YPL260W uniprot|Q7LGU3 Saccharomyces cerevisiae Hypothetical ORF SAKL0F05412g 0 418847 419878 ON 6 F05412 complement(418847..419878) some similarities with uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Protein involved in cell wall integrity and stress response SAKL0F05434g 1 420136 421518 ON 6 F05434 (420136..421518) some similarities with uniprot|Q08187 Saccharomyces cerevisiae YOL029C Hypothetical ORF SAKL0F05456g 0 421709 423166 ON 6 F05456 complement(421709..423166) similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall Sklu_6.trna14T 0 424376 424448 ON 6 tT-AGU complement(424376..424448) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 Sklu_6.trna15M 1 425379 425450 ON 6 tM-CAU (425379..425450) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.91 SAKL0F05544g 1 425732 426265 ON 6 F05544 (425732..426265) highly similar to gnl|GLV|KLLA0D14487g Kluyveromyces lactis KLLA0D14487g and similar to YMR009W uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway SAKL0F05566g 1 426515 427603 ON 6 F05566 (426515..427603) similar to uniprot|Q03687 YMR010W Saccharomyces cerevisiae Protein of unknown function SAKL0F05588g 0 427691 430324 ON 6 F05588 complement(427691..430324) similar to gnl|GLV|KLLA0D14531g Kluyveromyces lactis KLLA0D14531g and weakly similar to uniprot|P32606 YOR017W Saccharomyces cerevisiae PET127 Protein with a role in mitochondrial RNA stability and/or processing SAKL0F05610g 1 431111 432514 ON 6 F05610 (431111..432514) similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 The authentic non-tagged protein was localized to the mitochondria SAKL0F05632g 1 433052 434164 ON 6 F05632 (433052..434164) similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation Sklu_6.trna16P 0 434168 434271 ON 6 tP-UGG complement(434168..434203,434236..434271) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.25 SAKL0F05698g 1 434988 435620 ON 6 F05698 (434988..435620) highly similar to uniprot|Q12450 Saccharomyces cerevisiae and similar to uniprot|P39704 Saccharomyces cerevisiae YAL007C ERP2 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII- coated vesicles SAKL0F05720g 1 436495 437721 ON 6 F05720 (436495..437721) highly similar to uniprot|Q75A91 Ashbya gossypii ADR027W ADR027Wp and similar to YPR108W uniprot|Q06103 Saccharomyces cerevisiae SAKL0F05742g 1 438495 440159 ON 6 F05742 (438495..440159) highly similar to gnl|GLV|KLLA0D14685g Kluyveromyces lactis KLLA0D14685g and similar to YGR088W uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide Sklu_6.trna17L 0 440435 440518 ON 6 tL-UAA complement(440435..440518) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 69.31 Sklu_6.trna18Y 1 442890 442989 ON 6 tY-GUA (442890..442928,442954..442989) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 69.71 SAKL0F05918g 1 444390 446882 ON 6 F05918 (444390..446882) similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p which is a subunit of RNA polymerases I II and III computational analysis of large- scale protein-protein interaction data suggests a role in chromosome segregation Sklu_6.trna19T 1 447807 447878 ON 6 tT-UGU (447807..447878) tRNA Type: Thr (T) | Anti-Codon: UGU | Cove Score: 79.33 SAKL0F05984g 1 448144 451827 ON 6 F05984 (448144..451827) highly similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data SAKL0F06006g 1 452073 452999 ON 6 F06006 (452073..452999) similar to uniprot|Q6B2S3 Saccharomyces cerevisiae YPR109W Hypothetical ORF SAKL0F06028g 0 453180 454184 ON 6 F06028 complement(453180..454184) highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit common to RNA polymerase I and III SAKL0F06050g 1 454404 455825 ON 6 F06050 (454404..455825) similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor component of the U4/U6-U5 snRNP complex SAKL0F06072g 1 456175 457338 ON 6 F06072 (456175..457338) similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha- ketoglutarate dioxygenase SAKL0F06094g 1 457709 459442 ON 6 F06094 (457709..459442) uniprot|Q875S1 Saccharomyces kluyveri DBF2 SAKL0F06116g 1 459556 459825 ON 6 F06116 (459556..459825) no similarity SAKL0F06138g 1 460468 462109 ON 6 F06138 (460468..460556,460630..462109) similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Hypothetical ORF SAKL0F06160g 0 462236 464878 ON 6 F06160 complement(462236..464878) similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites shows partial nucleolar localization contains five consensus RNA-binding domains SAKL0F06182g 1 465219 468533 ON 6 F06182 (465219..468533) highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase SAKL0F06204g 0 468797 469468 ON 6 F06204 complement(468797..469468) similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases SAKL0F06226g 1 469718 470638 ON 6 F06226 (469718..470638) similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source SAKL0F06248g 1 470932 471603 ON 6 F06248 (470932..471603) highly similar to gnl|GLV|KLLA0D15037g Kluyveromyces lactis KLLA0D15037g and similar to YPR113W uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase required for biosynthesis of phosphatidylinositol which is a precursor for polyphosphoinositides sphingolipids and glycolipid anchors for some of the plasma membrane proteins SAKL0F06270g 1 472877 473932 ON 6 F06270 (472877..473932) similar to uniprot|P00331 Saccharomyces cerevisiae YMR303C ADH2 Glucose-repressible alcohol dehydrogenase II SAKL0F06292g 1 474396 475352 ON 6 F06292 (474396..475352) similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Hypothetical ORF SAKL0F06314g 1 477127 480159 ON 6 F06314 (477127..480159) similar to uniprot|P48361 Saccharomyces cerevisiae YGR097W ASK10 Component of the RNA polymerase II holoenzyme phosphorylated in response to oxidative stress has a role in destruction of Ssn8p which relieves repression of stress-response genes and some similarites with uniprot|Q06108 Saccharomyces cerevisiae YPR115W Hypothetical ORF SAKL0F06336g 0 480259 480882 ON 6 F06336 complement(480259..480882) conserved hypothetical protein SAKL0F06358g 1 481370 482395 ON 6 F06358 (481370..482395) weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W Hypothetical ORF SAKL0F06380g 0 482415 487337 ON 6 F06380 complement(482415..487337) similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin inhibited by Pds1p SAKL0F06402g 1 487543 489708 ON 6 F06402 (487543..489708) similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats required for telomere length regulation and telomere position effect SAKL0F06424g 1 490525 497946 ON 6 F06424 (490525..497946) similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Hypothetical ORF SAKL0F06446g 1 498840 501677 ON 6 F06446 (498840..501677) similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p Ypt31p and Sec4p involved in recycling of internalized proteins and regulation of Golgi secretory function SAKL0F06468g 1 501829 502920 ON 6 F06468 (501829..502920) similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology belongs to the rhomboid-GlpG superfamily of intramembrane peptidases SAKL0F06490g 0 503035 503592 ON 6 F06490 complement(503035..503592) similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Hypothetical ORF SAKL0F06512g 1 503813 505594 ON 6 F06512 (503813..505594) similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis constituent of several different pre-ribosomal particles SAKL0F06534g 0 505705 506508 ON 6 F06534 complement(505705..506508) similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 subunit of RNA polymerase II holoenzyme/mediator complex SAKL0F06556g 1 506694 507000 ON 6 F06556 (506694..506713,506793..507000) highly similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex SAKL0F06578g 0 507219 508004 ON 6 F06578 complement(507219..508004) weakly similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C Hypothetical ORF Sklu_6.trna20L 1 508212 508294 ON 6 tL-GAG (508212..508294) tRNA Type: Leu (L) | Anti-Codon: GAG | Cove Score: 64.57 SAKL0F06622g 1 508580 509824 ON 6 F06622 (508580..509824) highly similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W Methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1- phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Sklu_6.trna21K 0 510121 510210 ON 6 tK-UUU complement(510121..510156,510174..510210) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 SAKL0F06666g 1 512342 513838 ON 6 F06666 (512342..513838) similar to uniprot|P24869 Saccharomyces cerevisiae YPR119W CLB2 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24868 Saccharomyces cerevisiae YGR108W CLB1 SAKL0F06688g 0 514245 515498 ON 6 F06688 complement(514245..515498) similar to uniprot|P30283 Saccharomyces cerevisiae YPR120C CLB5 B-type cyclin with a role in DNA replication during S phase has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p and uniprot|P32943 Saccharomyces cerevisiae YGR109C CLB6 SAKL0F06710g 1 516999 517259 ON 6 F06710 (516999..517259) conserved hypothetical protein Sklu_6.trna22C 0 517598 517669 ON 6 tC-GCA complement(517598..517669) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.27 SAKL0F06809g1 1 518357 519679 ON 6 F06809 (518357..519679) Retrotransposon Gag gene co-transcribed with Pol SAKL0F06809g2 1 518357 523625 ON 6 F06809 (518357..519658,519660..523625) Retrotransposon Gag and Pol genes Sklu_6.trna23Y 1 524254 524353 ON 6 tY-GUA (524254..524292,524318..524353) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 71.70 SAKL0F06886g 1 524553 528104 ON 6 F06886 (524553..528104) similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a- factor mating pheromone required for axial budding pattern of haploid cells SAKL0F06908g 1 528556 529734 ON 6 F06908 (528556..529734) similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Hypothetical ORF Sklu_6.trna24G 0 530025 530095 ON 6 tG-GCC complement(530025..530095) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0F06974g 1 531394 531864 ON 6 F06974 (531394..531864) highly similar to gnl|GLV|KLLA0D15697g Kluyveromyces lactis and similar to YBR252W, uniprot|P33317 Saccharomyces cerevisiae YBR252W (DUT1), SAKL0F06996g 1 532082 532432 ON 6 F06996 (532082..532432) weakly similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Protein involved in transcription as part of the Srb/Mediator complex SAKL0F07018g 1 532804 534420 ON 6 F07018 (532804..534420) similar to uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules important for chromosome segregation SAKL0F07040g 0 534493 535008 ON 6 F07040 complement(534493..535008) similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 Trapp subunit of 20 kDa probable membrane protein mutations in the human homolog cause spondyloepiphyseal dysplasia tarda (SEDL) a genetically heterogeneous disorder characterized by short stature and early-onset osteoarthritis SAKL0F07062g 1 535182 536840 ON 6 F07062 (535182..536840) similar to uniprot|Q74ZF4 Ashbya gossypii AGR245C AGR245Cp and some similarites with YBR255W uniprot|P38335 Saccharomyces cerevisiae YBR255W Protein of unknown function required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0F07084g 0 536985 537430 ON 6 F07084 complement(536985..537281,537368..537430) similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Hypothetical ORF identified by homology SAKL0F07106g 0 537870 538727 ON 6 F07106 complement(537870..538727) similar to uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein that interacts with the karyopherin Srp1p may have a role with Srp1p in ubiquitin-mediated protein degradation SAKL0F07128g 1 539331 540632 ON 6 F07128 (539331..540632) similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification contains multiple WD repeats interacts with Qsr1p in the two-hybrid system SAKL0F07150g 0 540760 541464 ON 6 F07150 complement(540760..541464) highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase catalyzes the last step of the riboflavin biosynthesis pathway SAKL0F07172g 0 541680 543308 ON 6 F07172 complement(541680..543308) some similarities with uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. SAKL0F07194g 0 543951 545687 ON 6 F07194 complement(543951..545687) similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine SAKL0F07216g 0 547092 547640 ON 6 F07216 complement(547092..547640) some similarities with uniprot|P40548 Saccharomyces cerevisiae YIL016W SNL1 Integral membrane protein containing a Bag domain suppressor of nup116-C lethal SAKL0F07238g 1 548071 550749 ON 6 F07238 (548071..550749) similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Vacuole import and degradation SAKL0F07260g 1 551064 554351 ON 6 F07260 (551064..554351) similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase which is responsible for the conversion of sulfite into sulfide SAKL0F07282g 0 554459 557971 ON 6 F07282 complement(554459..557971) similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Component of the condensin complex essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase Smc2p/Smc4p complex binds DNA possibly in the cleft formed by the coiled-coil of the folded dimer SAKL0F07304g 0 558483 559672 ON 6 F07304 complement(558483..559243,559669..559672) highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W RPL2B and highly similar to uniprot|P05736 Saccharomyces cerevisiae YFR031C-A RPL2A, Protein component of the large (60S) ribosomal subunit SAKL0F07326g 0 560379 561308 ON 6 F07326 complement(560379..561308) weakly similar to uniprot|P43607 Saccharomyces cerevisiae YFR032C Hypothetical ORF SAKL0F07348g 0 561749 561940 ON 6 F07348 complement(561749..561940) highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit SAKL0F07370g 0 563147 564021 ON 6 F07370 complement(563147..563368,563944..564021) similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) SAKL0F07392g 0 565505 566953 ON 6 F07392 complement(565505..566953) some similarities with uniprot|P07270 Saccharomyces cerevisiae YFR034C PHO4 Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability SAKL0F07414g 0 567798 568811 ON 6 F07414 complement(567798..568811) similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly SAKL0F07436g 1 569205 569999 ON 6 F07436 (569205..569999) highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1- phosphoribosyl-4- imidazolecarboxiamide isomerase catalyzes the fourth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts SAKL0F07458g 0 570134 571081 ON 6 F07458 complement(570134..571081) highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W SAKL0F07480g 1 571315 571656 ON 6 F07480 (571315..571656) conserved hypothetical protein SAKL0F07502g 0 571758 572996 ON 6 F07502 complement(571758..572996) highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 48.8 kDa protein involved in mitochondrial protein import SAKL0F07524g 1 574092 577604 ON 6 F07524 (574092..577604) weakly similar to uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects potential Cdc28p substrate SAKL0F07546g 0 577875 581726 ON 6 F07546 complement(577875..581726) weakly similar to uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein Sklu_6.trna25K 0 581909 581981 ON 6 tK-CUU complement(581909..581981) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0F07590g 1 582153 582536 ON 6 F07590 (582153..582536) conserved hypothetical protein SAKL0F07612g 0 582579 583028 ON 6 F07612 complement(582579..583028) similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Protein of unknown function null mutant shows K1 killer toxin resistance SAKL0F07634g 0 583246 586506 ON 6 F07634 complement(583246..586506) similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms essential for viability SAKL0F07656g 0 587311 588124 ON 6 F07656 complement(587311..587859,587939..588124) similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Hypothetical protein SAKL0F07700g 0 588619 590118 ON 6 F07700 complement(588619..590118) similar to uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5 or uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 SAKL0F07722g 0 590938 592215 ON 6 F07722 complement(590938..592215) similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C Hypothetical ORF SAKL0F07744g 0 592416 593996 ON 6 F07744 complement(592416..593996) similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters SAKL0F07766g 1 594257 596551 ON 6 F07766 (594257..596551) similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF SAKL0F07788g 1 596801 598201 ON 6 F07788 (596801..598201) similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP- dependent protein kinase (PKA) SAKL0F07810g 0 598435 598881 ON 6 F07810 complement(598435..598881) highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p SAKL0F07832g 1 599267 600109 ON 6 F07832 (599267..600109) similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches SAKL0F07854g 1 600324 601442 ON 6 F07854 (600324..601442) highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2 SAKL0F07876g 0 601555 602871 ON 6 F07876 complement(601555..602715,602812..602871) weakly similar to uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Functions in early recombination mRNA is meiosis-specific and has 88 bp intron at 5' end spliced independently of MER1. SAKL0F07898g 0 603192 604433 ON 6 F07898 complement(603192..604433) weakly similar to uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non- optimal carbon sources SAKL0F07920g 1 604733 605500 ON 6 F07920 (604733..605500) similar to uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis SAKL0F07942g 1 605752 607626 ON 6 F07942 (605752..607626) weakly similar to uniprot|P40534 Saccharomyces cerevisiae YIL037C PRM2 Pheromone-regulated protein predicted to have 4 transmembrane segments and a coiled coil domain regulated by Ste12p SAKL0F07964g 1 608052 610541 ON 6 F07964 (608052..610541) some similarities with uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation SAKL0F07986g 0 610940 612076 ON 6 F07986 complement(610940..612076) conserved hypothetical protein SAKL0F08008g 0 612481 614844 ON 6 F08008 complement(612481..614844) similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system SAKL0F08030g 0 615027 616457 ON 6 F08030 complement(615027..616457) similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF SAKL0F08052g 0 616679 617860 ON 6 F08052 complement(616679..617860) highly similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family SAKL0F08074g 0 618624 619064 ON 6 F08074 complement(618624..619064) conserved hypothetical protein Sklu_6.trna26Q 1 619284 619355 ON 6 tQ-UUG (619284..619355) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0F08118g 1 619489 619770 ON 6 F08118 (619489..619770) similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A SAKL0F08140g 1 620298 622196 ON 6 F08140 (620298..622196) highly similar to uniprot|Q75AN6 Ashbya gossypii ADL114C ADL114Cp and similar to YER049W uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF SAKL0F08162g 0 622302 623294 ON 6 F08162 complement(622302..623294) highly similar to uniprot|Q75AN7 Ashbya gossypii ADL115W ADL115Wp and similar to YIL041W uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm SAKL0F08184g 1 623521 624759 ON 6 F08184 (623521..624759) similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF SAKL0F08206g 0 624892 625407 ON 6 F08206 complement(624892..625407) similar to gnl|GLV|KLLA0E04477g Kluyveromyces lactis KLLA0E04477g and some similarites with YER050C uniprot|P40033 Saccharomyces cerevisiae SAKL0F08250g 1 630032 631465 ON 6 F08250 (630032..631465) similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF SAKL0F08272g 1 631896 632756 ON 6 F08272 (631896..632756) similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase SAKL0F08294g 0 633032 634603 ON 6 F08294 complement(633032..634603) highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P- transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis SAKL0F08316g 0 634949 635485 ON 6 F08316 complement(634949..635485) some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions SAKL0F08338g 1 635682 636491 ON 6 F08338 (635682..636491) similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s) SAKL0F08360g 0 636693 637601 ON 6 F08360 complement(636693..637601) highly similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Mir1p but less abundant than Mir1p under normal conditions expression is induced at high temperature Sklu_YGOB_YER053C-A 0 638204 638317 ON 6 YER053C-A complement(638204..638317) ANNOTATED BY YGOB - SAKL0F08382g 0 638798 639997 ON 6 F08382 complement(638798..639997) similar to uniprot|Q75AL0 Ashbya gossypii ADL083C ADL083Cp and weakly similar to YER054C uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p SAKL0F08404g 0 640436 642367 ON 6 F08404 complement(640436..642367) similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus SAKL0F08426g 0 642995 643989 ON 6 F08426 complement(642995..643836,643938..643989) highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control SAKL0F08448g 1 644547 647147 ON 6 F08448 (644547..647147) similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein Sklu_6.trna27V 1 648821 648894 ON 6 tV-AAC (648821..648894) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0F08514g 0 649253 652684 ON 6 F08514 complement(649253..652684) highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases SAKL0F08536g 0 653122 654024 ON 6 F08536 complement(653122..653456,653988..654024) highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein SAKL0F08558g 0 654765 655199 ON 6 F08558 complement(654765..655199) highly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro SAKL0F08580g 1 655424 655795 ON 6 F08580 (655424..655795) similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase SAKL0F08602g 1 657898 659322 ON 6 F08602 (657898..659322) similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated SAKL0F08624g 1 660468 662009 ON 6 F08624 (660468..662009) similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 and similar to uniprot|Q12119 Saccharomyces cerevisiae YER060W-A FCY22 purine-cytosine permeases SAKL0F08646g 1 662235 663080 ON 6 F08646 (662235..663080) similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth SAKL0F08668g 0 663205 664506 ON 6 F08668 complement(663205..664506) similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase SAKL0F08690g 0 664940 665692 ON 6 F08690 complement(664940..665692) similar to uniprot|P41277 Saccharomyces cerevisiae RHR2 and to YER062C uniprot|P40106 Saccharomyces cerevisiae HOR2, two redundant DL-glycerol-3-phosphatases SAKL0F08712g 1 666544 667830 ON 6 F08712 (666544..667830) some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF SAKL0F08734g 0 668333 670216 ON 6 F08734 complement(668333..670216) similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription SAKL0F08756g 0 671190 672875 ON 6 F08756 complement(671190..672875) highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose Sklu_6.trna28S 0 673382 673463 ON 6 tS-UGA complement(673382..673463) tRNA Type: Ser (S) | Anti-Codon: UGA | Cove Score: 84.16 SAKL0F08800g 0 673754 674086 ON 6 F08800 complement(673754..674086) no similarity SAKL0F08822g 1 674447 674938 ON 6 F08822 (674447..674938) similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF SAKL0F08844g 1 675792 677642 ON 6 F08844 (675792..677642) similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C- terminal region of Not1p SAKL0F08866g 1 678049 679027 ON 6 F08866 (678049..678054,678125..679027) similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog SAKL0F08888g 1 679412 681979 ON 6 F08888 (679412..681979) highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl- phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p SAKL0F08910g 1 682226 682687 ON 6 F08910 (682226..682687) highly similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches SAKL0F08932g 1 682949 684022 ON 6 F08932 (682949..684022) weakly similar to uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p SAKL0F08954g 0 684068 684757 ON 6 F08954 complement(684068..684757) similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0F08976g 1 684881 685348 ON 6 F08976 (684881..685348) similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division SAKL0F08998g 1 687464 690121 ON 6 F08998 (687464..690121) highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits SAKL0F09020g 1 690638 692668 ON 6 F09020 (690638..692668) similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF SAKL0F09042g 1 692818 695205 ON 6 F09042 (692818..695205) similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis SAKL0F09064g 0 695230 695574 ON 6 F09064 complement(695230..695574) similar to uniprot|P40045 Saccharomyces cerevisiae YER071C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0F09086g 1 695889 696260 ON 6 F09086 (695889..696260) highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance SAKL0F09108g 1 697281 698825 ON 6 F09108 (697281..698825) highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme SAKL0F09130g 1 699129 699521 ON 6 F09130 (699129..699521) no similarity SAKL0F09152g 1 699580 700524 ON 6 F09152 (699580..699582,700120..700524) uniprot|Q875Q1 Saccharomyces kluyveri RPS24 SAKL0F09174g 1 700842 701180 ON 6 F09174 (700842..701180) similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Hypothetical ORF identified by homology. See FEBS Letters [2000]487:31-36. SAKL0F09196g 0 701787 704834 ON 6 F09196 complement(701787..704834) similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm SAKL0F09218g 1 705412 705774 ON 6 F09218 (705412..705774) no similarity Sklu_6.trna29A 0 705882 705954 ON 6 tA-UGC complement(705882..705954) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 73.87 SAKL0F09262g 1 706138 706911 ON 6 F09262 (706138..706911) similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R SAKL0F09284g 0 707171 709066 ON 6 F09284 complement(707171..709066) similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF SAKL0F09306g 1 709287 710570 ON 6 F09306 (709287..710570) similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain SAKL0F09328g 0 710704 712269 ON 6 F09328 complement(710704..712269) similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF SAKL0F09350g 0 712546 714500 ON 6 F09350 complement(712546..713644,713725..714500) similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation SAKL0F09372g 1 715477 715752 ON 6 F09372 (715477..715752) no similarity SAKL0F09394g 1 716507 717241 ON 6 F09394 (716507..717241) weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF SAKL0F09416g 1 717738 719603 ON 6 F09416 (717738..719603) highly similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria SAKL0F09438g 1 720044 722812 ON 6 F09438 (720044..722812) similar to uniprot|P40511 Saccharomyces cerevisiae YIL073C SAKL0F09460g 1 723369 724781 ON 6 F09460 (723369..724781) highly similar to uniprot|P40510 and to YER081W uniprot|P40054 Saccharomyces cerevisiae SER3 3- phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p SAKL0F09482g 1 725896 728712 ON 6 F09482 (725896..728712) highly similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p SAKL0F09504g 0 728890 730611 ON 6 F09504 complement(728890..730611) highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C SAKL0F09526g 1 731108 732448 ON 6 F09526 (731108..732448) uniprot|Q6V3W9 Saccharomyces kluyveri URA9 Dihydroorotate dehydrogenase, mitochondrial precursor SAKL0F09548g 0 732602 733519 ON 6 F09548 complement(732602..733519) similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function SAKL0F09570g 0 733682 734557 ON 6 F09570 complement(733682..734557) similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p SAKL0F09592g 1 736045 737034 ON 6 F09592 (736045..737034) similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF SAKL0F09614g 0 737281 739476 ON 6 F09614 complement(737281..739476) highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic SAKL0F09636g 1 740069 741166 ON 6 F09636 (740069..741166) similar to uniprot|P40507 Saccharomyces cerevisiae YIL079C and to similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C RING finger proteins that interact with the arginine methyltransferase Hmt1p Sklu_6.trna30I 0 741294 741367 ON 6 tI-AAU complement(741294..741367) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0F09702g 0 743532 745562 ON 6 F09702 complement(743532..745562) similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Hypothetical ORF SAKL0F09724g 1 745654 746217 ON 6 F09724 (745654..746217) similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF SAKL0F09746g 0 746292 747230 ON 6 F09746 complement(746292..747230) highly similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters SAKL0F09768g 0 747877 749496 ON 6 F09768 complement(747877..749496) highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix SAKL0F09790g 1 750158 751834 ON 6 F09790 (750158..751834) similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline- specific permease SAKL0F09812g 1 753062 753587 ON 6 F09812 (753062..753119,753190..753587) similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C SAKL0F09834g 1 753930 756458 ON 6 F09834 (753930..756458) highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome SAKL0F09856g 0 756909 757916 ON 6 F09856 complement(756909..757916) similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin- dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth SAKL0F09878g 0 758398 759615 ON 6 F09878 complement(758398..759615) similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W SAKL0F09900g 0 760089 761483 ON 6 F09900 complement(760089..761483) similar to gnl|GLV|KLLA0F05610g Kluyveromyces lactis KLLA0F05610g and weakly similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF SAKL0F09922g 0 762174 762842 ON 6 F09922 complement(762174..762842) weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF SAKL0F09944g 1 764320 764637 ON 6 F09944 (764320..764637) no similarity Sklu_6.trna31E 0 766404 766475 ON 6 tE-CUC complement(766404..766475) tRNA Type: Glu (E) | Anti-Codon: CUC | Cove Score: 64.72 SAKL0F09988g 0 767127 767384 ON 6 F09988 complement(767127..767384) similar to uniprot|P01097 Saccharomyces cerevisiae YDL181W INH1 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures SAKL0F10010g 1 767640 768644 ON 6 F10010 (767640..768644) similar to uniprot|Q75A19 Ashbya gossypii ADR108C ADR108Cp SAKL0F10032g 0 768839 769840 ON 6 F10032 complement(768839..769840) highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase SAKL0F10054g 0 770952 773375 ON 6 F10054 complement(770952..773375) highly similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation SAKL0F10076g 0 773641 775002 ON 6 F10076 complement(773641..775002) similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W SAKL0F10098g 1 775416 776330 ON 6 F10098 (775416..776330) similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF Sklu_YGOB_Anc_7.299 1 777073 777150 ON 6 Anc_7.299 (777073..777150) ANNOTATED BY YGOB - SAKL0F10120g 0 778451 780304 ON 6 F10120 complement(778451..780304) highly similar to uniprot|Q96UY4 Saccharomyces sp VMA1 VMA1 SAKL0F10142g 0 780604 781470 ON 6 F10142 complement(780604..781470) weakly similar to uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF SAKL0F10164g 1 782288 783355 ON 6 F10164 (782288..783355) highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C PPH21 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph22p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis SAKL0F10186g 0 783492 784082 ON 6 F10186 complement(783492..784082) conserved hypothetical protein SAKL0F10208g 1 784363 784968 ON 6 F10208 (784363..784968) highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor SAKL0F10230g 0 785180 786613 ON 6 F10230 complement(785180..786613) weakly similar to uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain SAKL0F10252g 1 786813 789677 ON 6 F10252 (786813..789677) highly similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex SAKL0F10274g 0 789877 790673 ON 6 F10274 complement(789877..790236,790671..790673) highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit SAKL0F10296g 0 791446 791991 ON 6 F10296 complement(791446..791991) highly similar to uniprot|P19146 Saccharomyces cerevisiae YDL137W ARF2 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf1p SAKL0F10318g 0 793294 793782 ON 6 F10318 complement(793294..793782) highly similar to uniprot|P19146 Saccharomyces cerevisiae YDL137W ARF2 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf1p SAKL0F10340g 0 795047 796114 ON 6 F10340 complement(795047..796114) similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1 SAKL0F10362g 0 796504 798711 ON 6 F10362 complement(796504..798711) similar to uniprot|P10870 Saccharomyces cerevisiae YDL194W SNF3 glucose sensor SAKL0F10384g 0 799553 803338 ON 6 F10384 complement(799553..803338) similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles SAKL0F10406g 1 805366 805617 ON 6 F10406 (805366..805617) similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF SAKL0F10428g 1 805705 806367 ON 6 F10428 (805705..806367) similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation SAKL0F10450g 1 806524 807636 ON 6 F10450 (806524..807636) similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity SAKL0F10472g 1 808869 814061 ON 6 F10472 (808869..814061) highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C SAKL0F10494g 0 814355 816403 ON 6 F10494 complement(814355..816403) similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase SAKL0F10516g 1 817088 817903 ON 6 F10516 (817088..817903) similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function SAKL0F10538g 0 818065 819651 ON 6 F10538 complement(818065..819651) highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo SAKL0F10560g 1 819907 820989 ON 6 F10560 (819907..820989) similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123 SAKL0F10582g 0 821259 823388 ON 6 F10582 complement(821259..823388) similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels SAKL0F10604g 1 824192 825265 ON 6 F10604 (824192..825265) similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF SAKL0F10626g 1 825574 827106 ON 6 F10626 (825574..827106) similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C SAKL0F10648g 1 827399 831010 ON 6 F10648 (827399..831010) highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway SAKL0F10670g 1 831263 832675 ON 6 F10670 (831263..832675) highly similar to uniprot|Q75A43 Ashbya gossypii ADR076C TUB4 Tubulin gamma chain and similar to YLR212C uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma- tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body SAKL0F10692g 0 832747 834204 ON 6 F10692 complement(832747..834204) similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck SAKL0F10714g 1 834974 835695 ON 6 F10714 (834974..834991,835048..835695) similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF SAKL0F10736g 0 835764 837089 ON 6 F10736 complement(835764..837089) highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid SAKL0F10758g 1 837399 839873 ON 6 F10758 (837399..839873) similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre- 18S rRNA SAKL0F10780g 0 839946 842735 ON 6 F10780 complement(839946..842735) similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre- autophagosomal structure and other cytosolic punctate structures not found in autophagosomes SAKL0F10802g 0 842942 844093 ON 6 F10802 complement(842942..844093) similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53 SAKL0F10824g 1 844268 846073 ON 6 F10824 (844268..846073) similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing SAKL0F10846g 0 846165 848942 ON 6 F10846 complement(846165..848530,848609..848942) similar to uniprot|Q12175 Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis msh5-Y823H mutation confers tolerance to DNA alkylating agents homologs present in C. elegans and humans SAKL0F10868g 0 849579 850949 ON 6 F10868 complement(849579..850949) similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3 SAKL0F10890g 0 852997 853257 ON 6 F10890 complement(852997..853257) no similarity SAKL0F10912g 0 854430 856511 ON 6 F10912 complement(854430..856511) similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination SAKL0F10934g 1 856966 858462 ON 6 F10934 (856966..858462) some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1 SAKL0F10956g 0 858747 859007 ON 6 F10956 complement(858747..859007) similar to uniprot|Q3E829 Saccharomyces cerevisiae YDL160C-A Putative protein of unknown function SAKL0F10978g 0 859590 860807 ON 6 F10978 complement(859590..860807) conserved hypothetical protein SAKL0F11000g 1 860972 863419 ON 6 F11000 (860972..863419) similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events SAKL0F11022g 1 863614 864504 ON 6 F11022 (863614..864504) highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles SAKL0F11044g 0 864648 865571 ON 6 F11044 complement(864648..865571) highly similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides SAKL0F11066g 1 865892 866197 ON 6 F11066 (865892..866197) no similarity SAKL0F11088g 0 866571 868064 ON 6 F11088 complement(866571..868064) highly similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation SAKL0F11110g 1 868447 869832 ON 6 F11110 (868447..869832) similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway SAKL0F11132g 0 869993 870316 ON 6 F11132 complement(869993..870316) similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF SAKL0F11154g 1 870446 871981 ON 6 F11154 (870446..871981) similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF SAKL0F11176g 0 872194 872931 ON 6 F11176 complement(872194..872931) similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF SAKL0F11198g 0 873587 875866 ON 6 F11198 complement(873587..875866) conserved hypothetical protein SAKL0F11220g 0 877190 877501 ON 6 F11220 complement(877190..877501) no similarity SAKL0F11242g 1 878709 879638 ON 6 F11242 (878709..879638) similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme SAKL0F11264g 0 879979 880290 ON 6 F11264 complement(879979..880290) no similarity SAKL0F11286g 1 880536 881807 ON 6 F11286 (880536..881807) similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA SAKL0F11308g 0 882040 882615 ON 6 F11308 complement(882040..882615) highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor SAKL0F11330g 1 882784 883410 ON 6 F11330 (882784..883410) similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response SAKL0F11352g 1 883590 885341 ON 6 F11352 (883590..885341) some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1 SAKL0F11374g 0 885478 886629 ON 6 F11374 complement(885478..886629) highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) SAKL0F11396g 1 886970 887734 ON 6 F11396 (886970..887734) similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53 SAKL0F11418g 0 887825 888172 ON 6 F11418 complement(887825..888172) similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene SAKL0F11440g 1 888319 889194 ON 6 F11440 (888319..888324,888382..889194) similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199c SAKL0F11462g 0 889390 890886 ON 6 F11462 complement(889390..890886) highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA SAKL0F11484g 1 893482 894009 ON 6 F11484 (893482..894009) similar to uniprot|Q75EK0 Ashbya gossypii AAR079C AAR079Cp and some similarites with YDL169C uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 Protein of unknown function SAKL0F11506g 0 894080 895786 ON 6 F11506 complement(894080..895786) similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1 SAKL0F11528g 1 896037 897386 ON 6 F11528 (896037..897386) highly similar to uniprot|Q75EK2 Ashbya gossypii AAR077C NMT1 Glycylpeptide N-tetradecanoyltransferase and similar to YLR195C uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction SAKL0F11550g 1 898638 899393 ON 6 F11550 (898638..899393) some similarities with uniprot|Q05777 Saccharomyces cerevisiae YLR194C Hypothetical ORF SAKL0F11572g 0 899557 899865 ON 6 F11572 complement(899557..899865) no similarity SAKL0F11594g 1 900058 900588 ON 6 F11594 (900058..900588) highly similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF SAKL0F11616g 0 901066 902841 ON 6 F11616 complement(901066..902841) similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma- aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1 UGA2 UGA4) zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type localized to the nucleus SAKL0F11638g 1 903534 909971 ON 6 F11638 (903534..909971) highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD(+)-dependent glutamate synthase (GOGAT) synthesizes glutamate from glutamine and alpha-ketoglutarate with Gln1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source SAKL0F11660g 0 910365 910910 ON 6 F11660 complement(910365..910910) some similarities with uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W Hypothetical ORF SAKL0F11682g 1 911211 912014 ON 6 F11682 (911211..912014) similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA SAKL0F11704g 1 912525 914219 ON 6 F11704 (912525..914219) similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane SAKL0F11726g 1 914950 915498 ON 6 F11726 (914950..915498) conserved hypothetical protein SAKL0F11748g 0 915861 917087 ON 6 F11748 complement(915861..917087) similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane receptor Sklu_6.trna32A 1 917918 917990 ON 6 tA-AGC (917918..917990) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0F11814g 0 918396 919763 ON 6 F11814 complement(918396..919763) weakly similar to uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane localizes only to mitochondria of the bud interacts with Myo2p to mediate mitochondrial distribution to buds mRNA is targeted to the bud via the transport system involving She2p SAKL0F11836g 1 920198 920437 ON 6 F11836 (920198..920437) no similarity SAKL0F11858g 1 920767 922455 ON 6 F11858 (920767..922455) highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation SAKL0F11880g 1 922955 924664 ON 6 F11880 (922955..924664) similar to uniprot|P39965 Saccharomyces cerevisiae YER087W Hypothetical ORF SAKL0F11902g 0 924736 925005 ON 6 F11902 complement(924736..925005) highly similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A SBH2 Ssh1p-Sss1p-Sbh2p complex component involved in protein translocation into the endoplasmic reticulum homologous to Sbh1p SAKL0F11924g 1 925625 927466 ON 6 F11924 (925625..927466) some similarities with uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage interacts with Rad53p contains an RNA recognition motif a nuclear localization signal and several SQ/TQ cluster domains hyperphosphorylated in response to DNA damage SAKL0F11946g 1 928792 931089 ON 6 F11946 (928792..931089) similar to gnl|GLV|KLLA0E20009g Kluyveromyces lactis KLLA0E20009g and weakly similar to YBL052C uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3 involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene sas3 gcn5 double mutation confers lethality SAKL0F11968g 0 931516 933264 ON 6 F11968 complement(931516..933264) some similarities with uniprot|P40059 Saccharomyces cerevisiae YER088C DOT6 Protein of unknown function involved in telomeric gene silencing and filamentation SAKL0F11990g 1 934213 935445 ON 6 F11990 (934213..935445) similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF SAKL0F12012g 0 935778 937163 ON 6 F12012 complement(935778..937163) similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation SAKL0F12034g 1 937503 939101 ON 6 F12034 (937503..939101) similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I SAKL0F12056g 1 939323 939943 ON 6 F12056 (939323..939943) similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase SAKL0F12078g 0 940018 941242 ON 6 F12078 complement(940018..941082,941150..941242) similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain- containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate SAKL0F12100g 0 941686 943989 ON 6 F12100 complement(941686..943989) highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase SAKL0F12122g 1 944868 945215 ON 6 F12122 (944868..945215) similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions SAKL0F12144g 0 945361 949362 ON 6 F12144 complement(945361..949362) similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability SAKL0F12166g 0 949531 950083 ON 6 F12166 complement(949531..949826,949912..950083) weakly similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF SAKL0F12188g 1 950237 950646 ON 6 F12188 (950237..950270,950360..950646) highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca SAKL0F12210g 0 950838 951660 ON 6 F12210 complement(950838..951430,951636..951660) highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10 SAKL0F12232g 0 952576 954450 ON 6 F12232 complement(952576..954450) similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF SAKL0F12254g 1 954676 955836 ON 6 F12254 (954676..955836) highly similar to gnl|GLV|YALI0F15477g Yarrowia lipolytica YALI0F15477g and similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein forms a helical filament with DNA that searches for homology involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis homolog of Dmc1p and bacterial RecA protein SAKL0F12276g 1 956186 958213 ON 6 F12276 (956186..958213) similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation SAKL0F12298g 0 958588 961926 ON 6 F12298 complement(958588..961926) similar to uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation functionally redundant with Cin8p SAKL0F12320g 1 963021 963767 ON 6 F12320 (963021..963767) highly similar to gnl|GLV|KLLA0E20383g Kluyveromyces lactis KLLA0E20383g and similar to YBL064C uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress SAKL0F12342g 1 964262 967393 ON 6 F12342 (964262..967393) similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Suppressor of Essential Function putative transcription factor Sklu_6.trna33P 1 968753 968824 ON 6 tP-GGG (968753..968824) tRNA Type: Pro (P) | Anti-Codon: GGG | Cove Score: 34.24 SAKL0F12430g 1 969369 971633 ON 6 F12430 (969369..971633) similar to uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions SAKL0F12452g 0 971802 972758 ON 6 F12452 complement(971802..972758) highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes SAKL0F12474g 1 974485 975240 ON 6 F12474 (974485..975240) similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER- associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway SAKL0F12496g 0 975352 976641 ON 6 F12496 complement(975352..976641) similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein SAKL0F12518g 0 977209 977457 ON 6 F12518 complement(977209..977457) highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p SAKL0F12540g 1 978415 979023 ON 6 F12540 (978415..979023) highly similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit SAKL0F12584g 1 979982 981154 ON 6 F12584 (979982..981154) similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre- mRNA of the MATa1 cistron SAKL0F12606g 1 981486 983453 ON 6 F12606 (981486..983453) highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family SAKL0F12628g 1 983841 987056 ON 6 F12628 (983841..987056) highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A SAKL0F12650g 1 987352 987933 ON 6 F12650 (987352..987933) conserved hypothetical protein SAKL0F12672g 1 988160 988519 ON 6 F12672 (988160..988519) highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy SAKL0F12694g 0 988977 993311 ON 6 F12694 complement(988977..993311) similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation SAKL0F12716g 1 993583 994716 ON 6 F12716 (993583..994716) some similarities with uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin kinetochore associated protein involved in chromosome attachment to meiotic spindle SAKL0F12738g 1 994959 996575 ON 6 F12738 (994959..996575) similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation SAKL0F12760g 0 997270 998271 ON 6 F12760 complement(997270..998271) some similarities with uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF SAKL0F12782g 0 999031 1000134 ON 6 F12782 complement(999031..1000134) highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p SAKL0F12804g 0 1000513 1002627 ON 6 F12804 complement(1000513..1002627) some similarities with uniprot|P40068 Saccharomyces cerevisiae YER109c PHD5 required for diploid filamentous growth singleton SAKL0F12826g 0 1003012 1004373 ON 6 F12826 complement(1003012..1004373) similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase involved in the synthesis of dolichol- linked oligosaccharide donor for N-linked glycosylation of proteins SAKL0F12848g 0 1004963 1008310 ON 6 F12848 complement(1004963..1008310) highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1 SAKL0F12870g 0 1009109 1011805 ON 6 F12870 complement(1009109..1011805) similar to gnl|GLV|KLLA0E20867g Kluyveromyces lactis KLLA0E20867g and some similarites with YER111C uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor SAKL0F12892g 1 1013209 1013724 ON 6 F12892 (1013209..1013724) weakly similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 component of small nuclear ribonucleoprotein complexes involved in RNA processing, splicing, and decay SAKL0F12914g 0 1013914 1016037 ON 6 F12914 complement(1013914..1016037) similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF SAKL0F12936g 1 1016829 1018727 ON 6 F12936 (1016829..1018727) similar to uniprot|Q751K0 Ashbya gossypii AGL294W AGL294Wp and some similarites with YBL084C uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition SAKL0F12958g 0 1019015 1022098 ON 6 F12958 complement(1019015..1022098) similar to uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud- emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain SAKL0F12980g 0 1022519 1023607 ON 6 F12980 complement(1022519..1023607) conserved hypothetical protein SAKL0F13002g 1 1023761 1025035 ON 6 F13002 (1023761..1025035) similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0F13024g 0 1025145 1026008 ON 6 F13024 complement(1025145..1026008) some similarities with uniprot|Q01684 Saccharomyces cerevisiae YER115C SPR6 sporulation-specific protein involved in sporulation SAKL0F13046g 0 1026073 1026882 ON 6 F13046 complement(1026073..1026882) weakly similar to uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair SAKL0F13068g 1 1027310 1028191 ON 6 F13068 (1027310..1027351,1027820..1028191) highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W SAKL0F13090g 1 1028424 1036793 ON 6 F13090 (1028424..1036793) similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene SAKL0F13112g 0 1037049 1038071 ON 6 F13112 complement(1037049..1038071) similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway SAKL0F13134g 0 1038673 1040205 ON 6 F13134 complement(1038673..1040205) similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters SAKL0F13156g 0 1040731 1041246 ON 6 F13156 complement(1040731..1041246) similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences SAKL0F13178g 1 1041547 1042797 ON 6 F13178 (1041547..1042797) highly similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p SAKL0F13200g 1 1043084 1044053 ON 6 F13200 (1043084..1043120,1043437..1044053) some similarities with uniprot|P40075 Saccharomyces cerevisiae YER120W SCS2 Protein likely to be involved in regulating INO1 expression suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline involved in inositol metabolism regulator of INO1 expression SAKL0F13222g 0 1044465 1044860 ON 6 F13222 complement(1044465..1044860) highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein SAKL0F13244g 1 1046281 1046895 ON 6 F13244 (1046281..1046895) similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component SAKL0F13266g 0 1047514 1048980 ON 6 F13266 complement(1047514..1048980) similar to uniprot|P38682 Saccharomyces cerevisiae YER122C SAKL0F13288g 0 1049320 1050033 ON 6 F13288 complement(1049320..1050033) similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF SAKL0F13310g 1 1051101 1053050 ON 6 F13310 (1051101..1053050) conserved hypothetical protein SAKL0F13332g 1 1053716 1055104 ON 6 F13332 (1053716..1055104) similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway SAKL0F13354g 1 1055553 1057775 ON 6 F13354 (1055553..1057775) similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics SAKL0F13376g 1 1058414 1060639 ON 6 F13376 (1058414..1060639) highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover SAKL0F13398g 0 1060920 1062029 ON 6 F13398 complement(1060920..1062029) similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters SAKL0F13420g 0 1062446 1064092 ON 6 F13420 complement(1062446..1064092) highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0F13442g 1 1065165 1068626 ON 6 F13442 (1065165..1068626) similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization Sklu_6.trna34F 0 1068792 1068884 ON 6 tF-GAA complement(1068792..1068827,1068848..1068884) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.92 SAKL0F13486g 1 1069115 1069732 ON 6 F13486 (1069115..1069165,1069238..1069732) similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion SAKL0F13508g 0 1069870 1072329 ON 6 F13508 complement(1069870..1072329) similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin- associated protein (AP) complex SAKL0F13530g 1 1073177 1076083 ON 6 F13530 (1073177..1076083) similar to gnl|GLV|CAGL0M09449g Candida glabrata CAGL0M09449g and weakly similar to YBL101C uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements SAKL0F13552g 0 1076192 1076833 ON 6 F13552 complement(1076192..1076833) highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W SAKL0F13563g 1 1077083 1078357 ON 6 F13563 (1077083..1078357) some similarities with uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways SAKL0F13574g 1 1078912 1081071 ON 6 F13574 (1078912..1081071) similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex SAKL0F13596g 1 1082310 1085321 ON 6 F13596 (1082310..1085321) highly similar to gnl|GLV|KLLA0E06435g Kluyveromyces lactis KLLA0E06435g and similar to YBL104C uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF SAKL0F13618g 1 1085967 1089494 ON 6 F13618 (1085967..1089494) similar to uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein Kinase C SAKL0F13640g 1 1089998 1093051 ON 6 F13640 (1089998..1093051) highly similar to gnl|GLV|KLLA0E06391g Kluyveromyces lactis KLLA0E06391g and similar to YBL106C uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YPR032W uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae SAKL0F13662g 1 1093181 1093771 ON 6 F13662 (1093181..1093771) similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF SAKL0F13684g 1 1094132 1095613 ON 6 F13684 (1094132..1095613) similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Tryptophan 2 3-dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway SAKL0F13706g 0 1095810 1097441 ON 6 F13706 complement(1095810..1097441) highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino- terminal sequence SAKL0F13728g 0 1097746 1098930 ON 6 F13728 complement(1097746..1098930) similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria SAKL0F13750g 0 1099212 1099517 ON 6 F13750 complement(1099212..1099517) some similarities with uniprot|Q75BT5 Ashbya gossypii ACR186W EAF6 Chromatin modification-related protein EAF6 and some similarites with YJR082C uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p- associated factor subunit of the NuA4 acetyltransferase complex SAKL0F13772g 1 1099703 1100971 ON 6 F13772 (1099703..1100971) similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex Sklu_YGOB_ACR183C 1 1101170 1101796 ON 6 ACR183C (1101170..1101427,1101431..1101796) ANNOTATED BY YGOB - SAKL0F13838g 1 1102770 1103879 ON 6 F13838 (1102770..1103879) highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS) synthesizes glutamine from glutamate and ammonia with Glt1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation SAKL0F13860g 1 1104604 1106013 ON 6 F13860 (1104604..1106013) similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 vacuolar ATPase V1 domain subunit H (54 kDa) SAKL0F13882g 0 1106374 1107201 ON 6 F13882 complement(1106374..1107201) weakly similar to uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization potential Cdc28p substrate SAKL0F13904g 1 1107394 1108647 ON 6 F13904 (1107394..1108647) similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W CSN12 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin- like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling Sklu_YGOB_Anc_7.453 1 1109540 1109686 ON 6 Anc_7.453 (1109540..1109686) ANNOTATED BY YGOB - SAKL0F13926g 0 1110172 1110489 ON 6 F13926 complement(1110172..1110489) similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Hypothetical ORF SAKL0F13948g 1 1112265 1112567 ON 6 F13948 (1112265..1112567) similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit forms a dimer with Ste4p to activate the mating signaling pathway forms a heterotrimer with Gpa1p and Ste4p to dampen signaling C- terminus is palmitoylated and farnesylated which are required for normal signaling SAKL0F13970g 0 1112601 1113203 ON 6 F13970 complement(1112601..1113203) similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen involved in disulfide bond formation within the ER SAKL0F13992g 1 1113332 1114378 ON 6 F13992 (1113332..1114378) similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein involved in regulation of the TOR pathway SAKL0F14014g 0 1114419 1115273 ON 6 F14014 complement(1114419..1115273) similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C Hypothetical ORF SAKL0F14036g 1 1115493 1116722 ON 6 F14036 (1115493..1116722) highly similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 eIF5 mediates hydrolysis of eIF2- GTP (SUI2 SUI3 GCD11) at start codons Translation initiation factor eIF-5 SAKL0F14058g 1 1117019 1120453 ON 6 F14058 (1117019..1120453) similar to uniprot|Q755W9 Ashbya gossypii AER399C AER399Cp and some similarites with YJR089W uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Protein involved in cell cycle regulation and chromosome segregation contains BIR (Baculovirus Inhibitor of apoptosis Repeat) domain SAKL0F14080g 0 1120568 1123918 ON 6 F14080 complement(1120568..1123918) similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin- ligase complex required for Cln1p and Cln2p degradation involved in carbon catabolite repression glucose-dependent divalent cation transport high-affinity glucose transport and morphogenesis SAKL0F14102g 0 1124333 1127449 ON 6 F14102 complement(1124333..1127449) similar to uniprot|P47135 Saccharomyces cerevisiae YJR091C JSN1 Member of the Puf family of RNA-binding proteins and to uniprot|Q12221 Saccharomyces cerevisiae YPR042C PUF2 mRNA binding protein SAKL0F14124g 1 1128851 1133248 ON 6 F14124 (1128851..1133248) weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding potential Cdc28p substrate SAKL0F14146g 0 1133375 1134274 ON 6 F14146 complement(1133375..1134274) some similarities with uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor SAKL0F14168g 0 1135147 1136268 ON 6 F14168 complement(1135147..1136268) weakly similar to uniprot|P21190 Saccharomyces cerevisiae YJR094c IME1 transcription factor required for sporulation SAKL0F14190g 0 1138506 1138754 ON 6 F14190 complement(1138506..1138754) no similarity SAKL0F14212g 1 1138868 1139596 ON 6 F14212 (1138868..1138869,1139320..1139596) highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W RPL43A Protein and uniprot|P49631 Saccharomyces cerevisiae YJR094W-A RPL43B Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype , member GLS.78 SAKL0F14234g 1 1140131 1141090 ON 6 F14234 (1140131..1141090) highly similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization SAKL0F14256g 0 1141479 1143572 ON 6 F14256 complement(1141479..1143572) no similarity SAKL0F14278g 1 1143922 1144782 ON 6 F14278 (1143922..1144782) highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W SAKL0F14300g 0 1144877 1145707 ON 6 F14300 complement(1144877..1145707) no similarity SAKL0F14322g 1 1146158 1147753 ON 6 F14322 (1146158..1147753) conserved hypothetical protein SAKL0F14344g 1 1148065 1148790 ON 6 F14344 (1148065..1148790) similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin hydrolyzes the peptide bond at the C-terminus of ubiquitin also the major processing enzyme for the ubiquitin-like protein Rub1p SAKL0F14366g 0 1148874 1150394 ON 6 F14366 complement(1148874..1150394) weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C Hypothetical ORF SAKL0F14388g 0 1150466 1151434 ON 6 F14388 complement(1150466..1151434) conserved hypothetical protein SAKL0F14410g 0 1151681 1152670 ON 6 F14410 complement(1151681..1152670) similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C Hypothetical ORF SAKL0F14432g 1 1153384 1154142 ON 6 F14432 (1153384..1154142) similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit SAKL0F14454g 0 1154197 1154754 ON 6 F14454 complement(1154197..1154754) similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome SAKL0F14476g 1 1154903 1155436 ON 6 F14476 (1154903..1155436) similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation binds to centromere DNA SAKL0F14498g 1 1156615 1158351 ON 6 F14498 (1156615..1158351) highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C SAKL0F14520g 0 1158791 1159326 ON 6 F14520 complement(1158791..1159242,1159314..1159326) highly similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cu Zn superoxide dismutase some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans SAKL0F14542g 0 1159517 1159693 ON 6 F14542 complement(1159517..1159693) some similarities with uniprot|P0C268 Saccharomyces cerevisiae YBL039W-B SAKL0F14564g 1 1159918 1160955 ON 6 F14564 (1159918..1160955) conserved hypothetical protein SAKL0F14586g 1 1161281 1162540 ON 6 F14586 (1161281..1162540) similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF SAKL0F14608g 0 1162905 1164140 ON 6 F14608 complement(1162905..1164140) similar to uniprot|P10823 Saccharomyces cerevisiae YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p has signaling role in response to nutrients green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0F14630g 0 1164522 1164854 ON 6 F14630 complement(1164522..1164854) conserved hypothetical protein SAKL0F14652g 0 1166099 1169467 ON 6 F14652 complement(1166099..1169467) similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor SAKL0F14674g 0 1170374 1172791 ON 6 F14674 complement(1170374..1172791) similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family SAKL0F14696g 1 1174646 1176749 ON 6 F14696 (1174646..1174684,1175901..1176749) highly similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17 SAKL0F14718g 1 1177621 1179759 ON 6 F14718 (1177621..1179759) weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels, member GLC.1409 SAKL0F14740g 1 1181696 1183831 ON 6 F14740 (1181696..1183831) weakly similar to uniprot|Q08908 Saccharomyces cerevisiae YOR384W FRE5 Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels SAKL0F14762g 1 1186204 1188396 ON 6 F14762 (1186204..1188396) weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters SAKL0F14784g 1 1193821 1195950 ON 6 F14784 (1193821..1195950) weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters SAKL0F14806g 1 1196694 1197047 ON 6 F14806 (1196694..1197047) similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1 SAKL0F14828g 1 1198356 1200377 ON 6 F14828 (1198356..1198379,1198446..1200377) similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate SAKL0F14850g 0 1200487 1201308 ON 6 F14850 complement(1200487..1201308) similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Hypothetical ORF SAKL0F14872g 1 1201428 1202036 ON 6 F14872 (1201428..1202036) similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation SAKL0F14894g 0 1202168 1206061 ON 6 F14894 complement(1202168..1206061) similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins binds membranes in a ubiquitin-dependent manner may also bind ubiquitinated membrane-associated proteins Sklu_6.trna35S 1 1207077 1207184 ON 6 tS-AGA (1207077..1207113,1207140..1207184) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.76 SAKL0F14960g 1 1207476 1207772 ON 6 F14960 (1207476..1207772) similar to uniprot|Q3E743 Saccharomyces cerevisiae YJR112W-A SAKL0F14982g 0 1207888 1208667 ON 6 F14982 complement(1207888..1208667) similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit SAKL0F15004g 1 1208883 1209905 ON 6 F15004 (1208883..1209905) some similarities with uniprot|P38193 Saccharomyces cerevisiae YBL046W Hypothetical ORF SAKL0F15026g 0 1210335 1211672 ON 6 F15026 complement(1210335..1211672) highly similar to uniprot|Q75D78 Ashbya gossypii ABR146W ABR146Wp and similar to YBL045C uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol- cytochrome c reductase complex (bc1 complex) which is a component of the mitochondrial inner membrane electron transport chain SAKL0F15048g 1 1212493 1212990 ON 6 F15048 (1212493..1212990) some similarities with uniprot|P38195 Saccharomyces cerevisiae YBL043W ECM13 Non-essential protein of unknown function SAKL0F15070g 1 1213643 1215403 ON 6 F15070 (1213643..1215403) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions SAKL0F15092g 1 1215605 1216390 ON 6 F15092 (1215605..1216390) highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 20S proteasome beta-type subunit SAKL0F15114g 0 1216468 1217191 ON 6 F15114 complement(1216468..1217105,1217167..1217191) similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins SAKL0F15136g 0 1217419 1219491 ON 6 F15136 complement(1217419..1219491) similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function SAKL0F15158g 0 1220221 1221438 ON 6 F15158 complement(1220221..1221438) similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 adenosine kinase SAKL0F15180g 1 1221606 1222424 ON 6 F15180 (1221606..1222424) similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF SAKL0F15202g 1 1223198 1224565 ON 6 F15202 (1223198..1224565) highly similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing contains multiple transmembrane spans SAKL0F15224g 1 1224823 1226328 ON 6 F15224 (1224823..1226328) similar to uniprot|P40016 Saccharomyces cerevisiae YER021W SAKL0F15246g 1 1226508 1228493 ON 6 F15246 (1226508..1228493) similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 subunit of RNA polymerase II holoenzyme/mediator complex SAKL0F15268g 0 1228520 1229065 ON 6 F15268 complement(1228520..1229065) similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function SAKL0F15290g 0 1229271 1231658 ON 6 F15290 complement(1229271..1231658) similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C Hypothetical ORF SAKL0F15312g 1 1232506 1233363 ON 6 F15312 (1232506..1233363) highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase catalyzes the last step in proline biosynthesis SAKL0F15334g 1 1233762 1235279 ON 6 F15334 (1233762..1235279) highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0F15356g 1 1236038 1237486 ON 6 F15356 (1236038..1237486) similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins SAKL0F15378g 1 1238152 1238829 ON 6 F15378 (1238152..1238829) highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W SAKL0F15400g 1 1239471 1241990 ON 6 F15400 (1239471..1241990) similar to uniprot|P40017 YER024W Saccharomyces cerevisiae YAT2 Carnitine acetyltransferase SAKL0F15422g 0 1242050 1243387 ON 6 F15422 complement(1242050..1243387) similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Hypothetical ORF SAKL0F15444g 1 1243590 1246484 ON 6 F15444 (1243590..1246484) similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate an intermediate in leucine biosynthesis SAKL0F15466g 1 1246818 1248368 ON 6 F15466 (1246818..1248368) highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 involved in the identification of the start codon binds GTP when forming the ternary complex with GTP and tRNAi-Met SAKL0F15488g 0 1248609 1250768 ON 6 F15488 complement(1248609..1250768) similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 Protein involved in desensitization to alpha- factor pheromone member of the RGS (regulator of G-protein signalling) family GTPase-activating protein SAKL0F15510g 0 1251475 1253373 ON 6 F15510 complement(1251475..1253373) similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 CDC28/cdc2 related protein kinase SAKL0F15532g 0 1253615 1255630 ON 6 F15532 complement(1253615..1255630) similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing SAKL0F15554g 0 1257392 1258573 ON 6 F15554 complement(1257392..1258573) similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B SAKL0F15576g 1 1260407 1268254 ON 6 F15576 (1260407..1268254) similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria SAKL0F15598g 1 1269034 1272540 ON 6 F15598 (1269034..1272540) weakly similar to uniprot|Q06211 Saccharomyces cerevisiae YPR164W MMS1 Protein likely involved in protection against replication-dependent DNA damage mutants are sensitive to methyl methanesulfonate (MMS) implicated in regulation of Ty1 transposition SAKL0F15620g 1 1272848 1273471 ON 6 F15620 (1272848..1273471) highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p) SAKL0F15642g 1 1273987 1274616 ON 6 F15642 (1273987..1274616) highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins involved in establishment of cell polarity regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1 3-beta-glucan synthase (Fks1p and Gsc2p) SAKL0F15664g 0 1275359 1275751 ON 6 F15664 complement(1275359..1275751) highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit SAKL0F15686g 0 1276276 1277061 ON 6 F15686 complement(1276276..1277061) highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'- bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism SAKL0F15708g 1 1277502 1277957 ON 6 F15708 (1277502..1277957) highly similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription SAKL0F15730g 1 1278090 1279715 ON 6 F15730 (1278090..1279715) similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein of unknown function exhibits a physical interaction with Bre1p Sklu_6.trna36I 0 1279856 1279929 ON 6 tI-AAU complement(1279856..1279929) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0F15796g 1 1280559 1280950 ON 6 F15796 (1280559..1280576,1280647..1280777,1280842..1280950) similar to uniprot|P0C5R8 Saccharomyces cerevisiae YPR170W-B or uniprot|P0C5R7 Saccharomyces cerevisiae YPR169W-A SAKL0F15818g 1 1281132 1282991 ON 6 F15818 (1281132..1282991) weakly similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton SAKL0F15840g 1 1283745 1284611 ON 6 F15840 (1283745..1284611) similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Hypothetical ORF SAKL0F15862g 1 1284800 1285408 ON 6 F15862 (1284800..1285408) similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance SAKL0F15884g 0 1285496 1286782 ON 6 F15884 complement(1285496..1286782) highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA- type ATPase SAKL0F15906g 0 1286984 1287940 ON 6 F15906 complement(1286984..1287940) similar to uniprot|Q758V0 Ashbya gossypii AEL266W AEL266Wp and weakly similar to YLR457C uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition SAKL0F15928g 1 1288291 1290450 ON 6 F15928 (1288291..1290450) similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate SAKL0F15950g 0 1290530 1291501 ON 6 F15950 complement(1290530..1291501) highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p SAKL0F15972g 1 1291625 1293037 ON 6 F15972 (1291625..1293037) similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex SAKL0F15994g 0 1293064 1294998 ON 6 F15994 complement(1293064..1294998) similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C SAKL0F16016g 1 1295299 1296261 ON 6 F16016 (1295299..1296261) similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability SAKL0F16038g 0 1296437 1298707 ON 6 F16038 complement(1296437..1298707) highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein SAKL0F16060g 1 1299085 1300257 ON 6 F16060 (1299085..1300257) similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI SAKL0F16082g 1 1300477 1300835 ON 6 F16082 (1300477..1300485,1300590..1300835) similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein SAKL0F16104g 1 1302134 1302931 ON 6 F16104 (1302134..1302931) highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P- Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation SAKL0F16126g 1 1303269 1307831 ON 6 F16126 (1303269..1307831) highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1 6- amyloglucosidase activities required for glycogen degradation SAKL0F16148g 1 1308459 1310474 ON 6 F16148 (1308459..1310474) similar to uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy SAKL0F16170g 0 1310627 1311940 ON 6 F16170 complement(1310627..1311940) similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers SAKL0F16192g 1 1312150 1312680 ON 6 F16192 (1312150..1312169,1312233..1312680) highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit SAKL0F16214g 0 1312909 1313382 ON 6 F16214 complement(1312909..1313382) similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin Myo1p binds to an IQ motif of Myo1p localization to the bud neck depends on Myo1p involved in the disassembly of the Myo1p ring SAKL0F16236g 1 1313573 1317799 ON 6 F16236 (1313573..1317799) similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain SAKL0F16258g 0 1317894 1319819 ON 6 F16258 complement(1317894..1319819) similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82 SAKL0F16280g 1 1320177 1321289 ON 6 F16280 (1320177..1321289) similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2 SAKL0F16302g 0 1322363 1324387 ON 6 F16302 complement(1322363..1324387) weakly similar to uniprot|Q12473 Saccharomyces cerevisiae YLL051C SAKL0F16324g 1 1326930 1328339 ON 6 F16324 (1326930..1328339) conserved hypothetical protein SAKL0F16346g 0 1331198 1332337 ON 6 F16346 complement(1331198..1332337) similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low-zinc conditions by the Zap1p transcription factor SAKL0F16412g 0 1346159 1346773 ON 6 F16412 complement(1346159..1346773) similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase SAKL0F16434g 1 1348589 1350778 ON 6 F16434 (1348589..1350778) some similarities with uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments SAKL0F16456g 1 1352921 1356766 ON 6 F16456 (1352921..1356766) highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF SAKL0F16478g 1 1357813 1359300 ON 6 F16478 (1357813..1359300) weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260w TNA1 SAKL0F16500g 0 1359448 1360257 ON 6 F16500 complement(1359448..1360257) conserved hypothetical protein SAKL0F16522g 1 1361716 1363842 ON 6 F16522 (1361716..1363842) some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type SAKL0F16544g 0 1364680 1366383 ON 6 F16544 complement(1364680..1366383) similar to gnl|GLV|KLLA0B14685g Kluyveromyces lactis KLLA0B14685g and weakly similar to YOR348C uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline- specific permease (also capable of transporting alanine and glycine) putative proline-specific permease SAKL0F16566g 1 1367791 1369212 ON 6 F16566 (1367791..1369212) weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine SAKL0F16588g 0 1369763 1371610 ON 6 F16588 complement(1369763..1371610) conserved hypothetical protein SAKL0F16610g 1 1373674 1375368 ON 6 F16610 (1373674..1375368) similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions SAKL0F16632g 0 1375911 1377758 ON 6 F16632 complement(1375911..1377758) similar to gnl|GLV|KLLA0F24200g Kluyveromyces lactis KLLA0F24200g and some similarities with uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 SAKL0F16654g 1 1378394 1378789 ON 6 F16654 (1378394..1378789) weakly similar to uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 SAKL0F16676g 0 1378786 1379070 ON 6 F16676 complement(1378786..1379070) no similarity SAKL0F16698g 1 1379406 1380428 ON 6 F16698 (1379406..1380428) similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF SAKL0F16720g 1 1381235 1382257 ON 6 F16720 (1381235..1382257) similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF SAKL0F16742g 0 1382681 1382971 ON 6 F16742 complement(1382681..1382971) no similarity SAKL0F16764g 1 1384018 1384872 ON 6 F16764 (1384018..1384872) some similarities with uniprot|Q7LGR3 Saccharomyces cerevisiae YDL218W Putative protein of unknown function SAKL0G00110g 1 4170 5603 ON 7 G00110 (4170..5603) weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome Stability SAKL0G00132g 1 10237 11700 ON 7 G00132 (10237..11700) similar to uniprot|Q75A58 Ashbya gossypii ADR061C ADR061Cp and weakly similar to YBR158W uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome Stability SAKL0G00154g 1 13801 14259 ON 7 G00154 (13801..14259) conserved hypothetical protein SAKL0G00176g 1 14741 15364 ON 7 G00176 (14741..15364) no similarity SAKL0G00352g 1 28506 29915 ON 7 G00352 (28506..29915) similar to uniprot|P23503 YNL240C Saccharomyces cerevisiae NAR1 Nuclear architecture related protein component of the cytosolic iron-sulfur (FeS) protein assembly machinery SAKL0G00374g 1 30142 31665 ON 7 G00374 (30142..31665) highly similar to uniprot|P11412 YNL241C Saccharomyces cerevisiae ZWF1 Glucose-6-phosphate dehydrogenase SAKL0G00396g 0 31891 35097 ON 7 G00396 complement(31891..35097) similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis SAKL0G00418g 0 35455 40170 ON 7 G00418 complement(35455..40170) similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy SAKL0G00440g 1 41016 43526 ON 7 G00440 (41016..43526) similar to uniprot|P13134 YNL238W Saccharomyces cerevisiae KEX2 Subtilisin-like protease (proprotein convertase) SAKL0G00462g 1 44013 45365 ON 7 G00462 (44013..45365) similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W YTP1 Probable type-III integral membrane protein of unknown function SAKL0G00484g 0 47279 48703 ON 7 G00484 complement(47279..48703) highly similar to uniprot|Q01532 Saccharomyces cerevisiae YNL239W LAP3 Aminopeptidase of cysteine protease family has a DNA binding activity and acts as bleomycin hydrolase in vitro transcription is regulated by galactose via Gal4p SAKL0G00506g 1 49770 50786 ON 7 G00506 (49770..50786) highly similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane involved in turnover of membrane-embedded proteins member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes SAKL0G00528g 0 50858 54226 ON 7 G00528 complement(50858..54226) similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing exhibits ATP- dependent RNA unwinding activity SAKL0G00550g 1 54634 55236 ON 7 G00550 (54634..55236) similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit SAKL0G00572g 0 55839 56333 ON 7 G00572 complement(55839..56333) conserved hypothetical protein SAKL0G00594g 1 56571 59416 ON 7 G00594 (56571..56847,57111..59416) similar to uniprot|P32769 Saccharomyces cerevisiae YKR084C HBS1 GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components SAKL0G00616g 0 59495 60487 ON 7 G00616 complement(59495..60487) similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex potential Cdc28p substrate endoplasmic reticulum t- SNARE coprecipitates with Sec20p Tip1p. and Sec22p SAKL0G00638g 1 60782 61714 ON 7 G00638 (60782..61714) highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides expression is induced at G1/S SAKL0G00660g 0 61760 63520 ON 7 G00660 complement(61760..63520) weakly similar to uniprot|Q08490 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint involved in sensing lack of tension on mitotic chromosomes SAKL0G00682g 1 63745 64074 ON 7 G00682 (63745..64074) similar to uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore SAKL0G00704g 0 64152 67577 ON 7 G00704 complement(64152..67577) similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p SAKL0G00726g 1 67780 68883 ON 7 G00726 (67780..67793,67878..68883) highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2 SAKL0G00748g 0 68995 69963 ON 7 G00748 complement(68995..69963) highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5 10- methylenetetrahydrafolate dehydrogenase plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p repressed by adenine and may be induced by inositol and choline SAKL0G00770g 1 70704 72419 ON 7 G00770 (70704..72419) similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p Sec4p Ypt7p and Ypt51p (in vitro) involved in vesicle docking and fusion SAKL0G00792g 1 72744 75197 ON 7 G00792 (72744..75197) similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 Protein required for cell viability SAKL0G00814g 0 75297 77240 ON 7 G00814 complement(75297..77240) similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W VPS5 Component of the retromer coat that retrieves proteins from late endosomes sorting nexin I homolog SAKL0G00836g 1 77387 79072 ON 7 G00836 (77387..79072) highly similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 adds glucose to the dolichol- linked oligosaccharide precursor prior to transfer to protein glycosyl transferase SAKL0G00858g 0 79195 80715 ON 7 G00858 complement(79195..80715) weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W Protein of unknown function potential Cdc28p substrate SAKL0G00880g 0 81129 82220 ON 7 G00880 complement(81129..82220) similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W ECM4 and to YMR251W uniprot|Q04806 Saccharomyces cerevisiae YMR251W Hypothetical ORF SAKL0G00902g 0 83001 83983 ON 7 G00902 complement(83001..83852,83942..83983) highly similar to uniprot|P07143 Saccharomyces cerevisiae YOR065W CYT1 Cytochrome c1 component of the mitochondrial respiratory chain expression is regulated by the heme-activated glucose-repressed Hap2p/3p/4p/5p CCAAT- binding complex SAKL0G00924g 1 84356 84973 ON 7 G00924 (84356..84973) weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Yeast homolog of mammalian Ing1 histone acetyltransferase complex component SAKL0G00946g 0 85126 86292 ON 7 G00946 complement(85126..86292) highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W SAKL0G00968g 1 88539 89384 ON 7 G00968 (88539..89384) similar to uniprot|P36025 Saccharomyces cerevisiae YOR062C SAKL0G00990g 0 89700 90824 ON 7 G00990 complement(89700..90824) highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 may have a role in regulation and/or execution of the eukaryotic cell cycle alpha' subunit of casein kinase II SAKL0G01012g 1 90920 91660 ON 7 G01012 (90920..91660) similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C Protein required for cell viability SAKL0G01034g 1 91773 93110 ON 7 G01034 (91773..93110) similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF SAKL0G01056g 0 93113 93622 ON 7 G01056 complement(93113..93498,93565..93622) similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W Hypothetical ORF Sklu_7.trna1K 0 93750 93839 ON 7 tK-UUU complement(93750..93785,93803..93839) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 69.09 SAKL0G01100g 1 94036 96789 ON 7 G01100 (94036..96789) similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Member of a family of microtubule-associated proteins (MAPs) that function at the mitotic spindle midzone required for spindle elongation undergoes cell cycle-regulated degradation by anaphase promoting complex potential Cdc28p substrate SAKL0G01122g 0 96932 98089 ON 7 G01122 complement(96932..98089) similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Probable cochaperone regulates activity of Cyr1p (adenylyl cyclase) involved in assembly of the kinetochore complex associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex SAKL0G01144g 1 98449 99990 ON 7 G01144 (98449..99990) similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Nin1 (One) Binding protein essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosome subunits required for cleavage of the 20S pre- rRNA to generate the mature 18S rRNA. SAKL0G01166g 1 100231 102153 ON 7 G01166 (100231..102153) similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C VHS3 Regulatory subunit of Ppz1p which is an isoform of serine/threonine protein phosphatase Z involved in regulation of potassium transport overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation SAKL0G01188g 1 102395 103417 ON 7 G01188 (102395..103417) similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2 SAKL0G01210g 1 104721 105071 ON 7 G01210 (104721..105071) some similarities with uniprot|O00017 Saccharomyces cerevisiae YOR052C SAKL0G01232g 0 105188 106264 ON 7 G01232 complement(105188..106264) similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF SAKL0G01254g 0 106478 108256 ON 7 G01254 complement(106478..108256) similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase SAKL0G01276g 1 108616 109974 ON 7 G01276 (108616..109974) similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0G01298g 1 110216 110833 ON 7 G01298 (110216..110833) highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles component of the TRAPP (transport protein particle) complex SAKL0G01320g 0 110958 113066 ON 7 G01320 complement(110958..113066) similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone which are intermediate steps in lipid biosynthesis SAKL0G01342g 1 113536 114612 ON 7 G01342 (113536..114612) similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane SAKL0G01364g 0 114631 115803 ON 7 G01364 complement(114631..115803) similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Hypothetical ORF SAKL0G01386g 1 116704 119556 ON 7 G01386 (116704..119556) similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease involved in RNA metabolism including rRNA and snRNA processing as well as mRNA transcription termination SAKL0G01430g 0 121346 121798 ON 7 G01430 complement(121346..121798) some similarities with uniprot|P40103 Saccharomyces cerevisiae YER188W Hypothetical ORF Sklu_7.trna2E 1 122189 122260 ON 7 tE-UUC (122189..122260) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0G01474g 1 122929 124110 ON 7 G01474 (122929..124110) similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C MTH1 Negative regulator of the glucose-sensing signal transduction pathway required for repression of transcription by Rgt1p interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors phosphorylated by Yck1p triggering Mth1p degradation SAKL0G01496g 1 125044 126568 ON 7 G01496 (125044..125050,125133..126568) similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus Sklu_YGOB_Anc_5.642 1 126870 127111 ON 7 Anc_5.642 (126870..126911,126977..127111) ANNOTATED BY YGOB - Intron-containing gene - Search-DOGS addition SAKL0G01518g 0 127704 127877 ON 7 G01518 complement(127704..127877) similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components; outer mitochondrial membrane protein, component of the mitochondiral protein translocation complex, associates with TOM40 Sklu_YGOB_Anc_5.640 0 128356 128751 ON 7 Anc_5.640 complement(128356..128751) ANNOTATED BY YGOB - SAKL0G01540g 0 128999 130309 ON 7 G01540 complement(128999..130309) similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required with binding partner Psr1p for full activation of the general stress response possibly through Msn2p dephosphorylation regulates growth during the diauxic shift negative regulator of G1 cyclin expression SAKL0G01584g 0 130949 132163 ON 7 G01584 complement(130949..132163) weakly similar to uniprot|Q08412 Saccharomyces cerevisiae YOR042W CUE5 Protein containing a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0G01606g 0 132663 133511 ON 7 G01606 complement(132663..133511) similar to uniprot|Q12320 Saccharomyces cerevisiae YOR040W GLO4 Mitochondrial glyoxalase II catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate SAKL0G01628g 0 133626 136505 ON 7 G01628 complement(133626..136505) conserved hypothetical protein SAKL0G01650g 0 137067 140009 ON 7 G01650 complement(137067..140009) similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)- transporting ATPase SAKL0G01672g 0 141567 142388 ON 7 G01672 complement(141567..142388) highly similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 protein kinase CK2 beta' subunit SAKL0G01694g 1 142556 145099 ON 7 G01694 (142556..145099) similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p SAKL0G01716g 0 145137 146255 ON 7 G01716 complement(145137..146255) similar to uniprot|P04803 YDR268W Saccharomyces cerevisiae MSW1 Mitochondrial tryptophanyl-tRNA synthetase SAKL0G01738g 0 146447 147625 ON 7 G01738 complement(146447..147625) similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p) potential Cdc28p substrate SAKL0G01760g 1 147664 148656 ON 7 G01760 (147664..148656) highly similar to Q05583 YDR267C uniprot|Q05583 Saccharomyces cerevisiae CIA1 Protein required for cell viability SAKL0G01782g 0 148690 149529 ON 7 G01782 complement(148690..149529) similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic endocytic and retrograde traffic into the prevacuolar compartment syntaxin SAKL0G01804g 0 150598 151684 ON 7 G01804 complement(150598..151510,151566..151684) similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum required for normal content of cell wall beta-1 6-glucan SAKL0G01826g 0 152168 154231 ON 7 G01826 complement(152168..154231) weakly similar to uniprot|P50273 YDR350C Saccharomyces cerevisiae CM10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase SAKL0G01848g 1 154547 157204 ON 7 G01848 (154547..157204) weakly similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 kinase family required for cell integrity possibly through regulating 1 6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin) which is a component of the spindle pole body SAKL0G01870g 1 157481 159769 ON 7 G01870 (157481..159769) weakly similar to uniprot|P38814 YHR103W Saccharomyces cerevisiae SBE Protein involved in the transport of cell wall components from the Golgi to the cell surface SAKL0G01892g 1 160278 161150 ON 7 G01892 (160278..161150) similar to uniprot|Q06328 YDR352w Saccharomyces cerevisiae Hypothetical ORF SAKL0G01914g 1 162612 163601 ON 7 G01914 (162612..163601) highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal d-xylose and arabinose metabolism stress induced (osmotic ionic oxidative heat shock starvation and heavy metals) regulated by the HOG pathway SAKL0G01936g 1 163942 164439 ON 7 G01936 (163942..164439) similar to uniprot|P38815 Saccharomyces cerevisiae YHR105W YPT35 Hypothetical ORF SAKL0G01958g 1 164674 165666 ON 7 G01958 (164674..165666) highly similar to uniprot|P29509 YDR353W Saccharomyces cerevisiae TRR1 Thioredoxin reductase SAKL0G01980g 0 166103 167266 ON 7 G01980 complement(166103..167266) highly similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM SAKL0G02002g 1 167884 168984 ON 7 G02002 (167884..168984) similar to uniprot|P07285 YDR354W Saccharomyces cerevisiae TRP4 anthranilate phosphoribosyl transferase SAKL0G02024g 1 169807 172356 ON 7 G02024 (169807..172356) weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component ortholog of human kendrin involved in connecting nuclear microtubules to SPB interacts with Tub4p-complex and calmodulin phosphorylated by Mps1p in cell cycle-dependent manner SAKL0G02046g 0 172429 172785 ON 7 G02046 complement(172429..172785) similar to uniprot|Q06333 YDR357C Saccharomyces cerevisiae Protein of unknown function SAKL0G02068g 1 173020 174750 ON 7 G02068 (173020..174750) similar to uniprot|P38817 YHR108W Saccharomyces cerevisiae GGA2 Golgi-localized protein with homology to gamma-adaptin SAKL0G02090g 0 174883 177447 ON 7 G02090 complement(174883..177447) similar to uniprot|Q06337 YDR359C Saccharomyces cerevisiae VID21 Component of the NuA4 histone acetyltransferase complex SAKL0G02112g 0 177769 178590 ON 7 G02112 complement(177769..178590) similar to uniprot|Q06338 YDR361C Saccharomyces cerevisiae BCP1 Essential protein involved in nuclear export of Mss4p SAKL0G02134g 1 178980 180740 ON 7 G02134 (178980..180740) similar to uniprot|P38818 Saccharomyces cerevisiae YHR109W CTM1 Cytochrome c lysine methyltransferase trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol not required for normal respiratory growth SAKL0G02156g 1 181169 181798 ON 7 G02156 (181169..181798) similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W SAKL0G02178g 1 182328 183647 ON 7 G02178 (182328..183647) similar to uniprot|P38820 YHR111W Saccharomyces cerevisiae UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation) SAKL0G02200g 0 183723 185696 ON 7 G02200 complement(183723..185696) similar to uniprot|Q06339 YDR362C Saccharomyces cerevisiae TFC6 one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) SAKL0G02222g 0 186449 187585 ON 7 G02222 complement(186449..187585) highly similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF SAKL0G02244g 1 188137 189621 ON 7 G02244 (188137..189621) highly similar to uniprot|P38821 YHR113W Saccharomyces cerevisiae Hypothetical ORF SAKL0G02266g 1 190967 192421 ON 7 G02266 (190967..192421) some similarities with uniprot|Q06340 YDR363W Saccharomyces cerevisiae ESC2 Protein involved in mating- type locus silencing interacts with Sir2p Sklu_7.trna3K 1 193375 193447 ON 7 tK-CUU (193375..193447) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G02354g 0 193623 197999 ON 7 G02354 complement(193623..197999) highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C Sklu_YGOB_Anc_5.427 1 198366 198572 ON 7 Anc_5.427 (198366..198572) ANNOTATED BY YGOB - SAKL0G02376g 1 198787 200091 ON 7 G02376 (198787..200091) highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription SAKL0G02398g 0 200123 201538 ON 7 G02398 complement(200123..201538) similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression required for DNA synthesis during mitosis and meiosis has WD repeats Sklu_7.trna4K 1 201690 201762 ON 7 tK-CUU (201690..201762) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G02442g 0 201924 203795 ON 7 G02442 complement(201924..203795) similar to uniprot|Q06344 YDR365C Saccharomyces cerevisiae ESF1 Nucleolar protein involved in pre-rRNA processing SAKL0G02464g 1 204358 206049 ON 7 G02464 (204358..206049) similar to uniprot|Q12108 YOR118W Saccharomyces cerevisiae Hypothetical ORF SAKL0G02486g 0 206119 207621 ON 7 G02486 complement(206119..207621) similar to uniprot|Q12196 YOR119C Saccharomyces cerevisiae RIO1 Essential protein that plays a role in cell cycle progression SAKL0G02508g 1 207823 208593 ON 7 G02508 (207823..207855,207940..208593) similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0G02530g 1 208952 209890 ON 7 G02530 (208952..209890) similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism SAKL0G02552g 0 209978 212482 ON 7 G02552 complement(209978..212482) weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 classified as an early recombination function required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth) required for double strand breaks meiotic recombination and spore viability DNA repair protein SAKL0G02574g 0 212991 214445 ON 7 G02574 complement(212991..214445) conserved hypothetical protein SAKL0G02596g 0 214675 215877 ON 7 G02596 complement(214675..215877) weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Hypothetical ORF SAKL0G02618g 1 217435 217749 ON 7 G02618 (217435..217749) conserved hypothetical protein SAKL0G02640g 0 217953 218479 ON 7 G02640 complement(217953..218320,218467..218479) highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin actin- and phosphatidylinositol 4 5-bisphosphate-binding protein plays a role in cytoskeleton organization required for normal timing of actin polymerization in response to thermal stress localizes to plasma membrane and cytosol SAKL0G02662g 0 218969 220408 ON 7 G02662 complement(218969..220408) similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex which associates with RNA polymerase II and is involved in histone methylation SAKL0G02684g 1 220460 222079 ON 7 G02684 (220460..222079) similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Sporulation-specific chitinase SAKL0G02706g 0 222134 223132 ON 7 G02706 complement(222134..223132) highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74 SAKL0G02728g 0 223607 227320 ON 7 G02728 complement(223607..227320) similar to uniprot|Q01476 Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions capable of cleaving polyubiquitin and possesses isopeptidase activity SAKL0G02750g 1 227920 228492 ON 7 G02750 (227920..228492) highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4- kinase Pik1p member of the recoverin/frequenin branch of the EF-hand superfamily SAKL0G02772g 0 228664 229359 ON 7 G02772 complement(228664..229359) similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis essential for several other metabolic pathways including respiration and gluconeogenic gene activation SAKL0G02794g 0 229453 230322 ON 7 G02794 complement(229453..230322) similar to uniprot|Q06390 Saccharomyces cerevisiae YDR374C Hypothetical ORF Sklu_YGOB_YDR374W-A 1 230804 231028 ON 7 YDR374W-A (230804..231028) ANNOTATED BY YGOB - SAKL0G02816g 0 231094 232560 ON 7 G02816 complement(231094..232560) similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins member of the CDC48/PAS1/SEC18 ATPase family SAKL0G02838g 0 232634 233365 ON 7 G02838 complement(232634..233365) similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate which is particularly important in sake brewing SAKL0G02860g 1 233914 235383 ON 7 G02860 (233914..235383) similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster- containing enzymes one of the few mitochondrial proteins essential for viability SAKL0G02882g 1 235583 236225 ON 7 G02882 (235583..235639,235977..236225) similar to Q06405 Saccharomyces cerevisae YDR377w, ATP synthase subunit f, ATP17 SAKL0G02904g 0 236501 236755 ON 7 G02904 complement(236501..236755) similar to uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay SAKL0G02926g 1 237159 240035 ON 7 G02926 (237159..240035) similar to uniprot|Q06407 Saccharomyces cerevisiae YDR379W RGA2 GTPase-activating protein for the polarity- establishment protein Cdc42p implicated in control of septin organization pheromone response and haploid invasive growth SAKL0G02948g 0 240206 240445 ON 7 G02948 complement(240206..240445) similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Hypothetical protein identified by homology SAKL0G02970g 1 241733 243394 ON 7 G02970 (241733..243394) uniprot|Q8TGC9 Saccharomyces kluyveri Putative ceramide glucosyltransferase SAKL0G02992g 1 243859 247044 ON 7 G02992 (243859..247044) conserved hypothetical protein SAKL0G03014g 0 247184 248911 ON 7 G03014 complement(247184..248911) highly similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway red pigment accumulates in mutant cells deprived of adenine SAKL0G03036g 1 250012 251925 ON 7 G03036 (250012..251925) similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde which is the first specific step in the Ehrlich pathway SAKL0G03058g 0 252139 254901 ON 7 G03058 complement(252139..254901) weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C Putative component of the outer plaque of the spindle pole body may be involved in cation homeostasis or multidrug resistance SAKL0G03080g 1 255941 257346 ON 7 G03080 (255941..256189,256954..257346) similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 Nuclear protein that binds to RNA and to Mex67p required for export of poly(A) mRNA from the nucleus member of the REF (RNA and export factor binding proteins) family another family member Yra2p can substitute for Yra1p function SAKL0G03102g 0 257619 258093 ON 7 G03102 complement(257619..257910,258065..258093) similar to uniprot|Q3E6R5 Saccharomyces cerevisiae YDR381C-A Hypothetical ORF identified by homology SAKL0G03124g 1 259110 260081 ON 7 G03124 (259110..260081) weakly similar to uniprot|P39953 Saccharomyces cerevisiae YEL006W Hypothetical ORF SAKL0G03146g 0 260142 260978 ON 7 G03146 complement(260142..260978) similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane exports ornithine from mitochondria as part of arginine biosynthesis human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome SAKL0G03168g 1 261471 261800 ON 7 G03168 (261471..261800) highly similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm SAKL0G03190g 0 261881 262573 ON 7 G03190 complement(261881..262573) weakly similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C NKP1 Sklu_7.trna5D 1 264378 264449 ON 7 tD-GUC (264378..264449) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0G03278g 0 264888 265721 ON 7 G03278 complement(264888..265721) similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters SAKL0G03300g 1 268199 270049 ON 7 G03300 (268199..270049) similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores SAKL0G03322g 0 271823 272638 ON 7 G03322 complement(271823..272638) similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters SAKL0G03344g 0 274337 275085 ON 7 G03344 complement(274337..274893,274977..275085) similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Hypothetical ORF SAKL0G03366g 1 275254 276876 ON 7 G03366 (275254..276876) similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Peripheral membrane protein required for vacuolar protein sorting SAKL0G03388g 1 277210 279738 ON 7 G03388 (277210..279738) uniprot|Q875S0 Saccharomyces kluyveri EFT2 Elongation factor 2 SAKL0G03410g 1 280088 282010 ON 7 G03410 (280088..282010) similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Helix-hairpin-helix protein involved in DNA repair and replication fork stability functions as an endonuclease in complex with Mms4p interacts with Rad54p SAKL0G03432g 0 282042 283655 ON 7 G03432 complement(282042..283655) similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Hypothetical ORF SAKL0G03454g 1 284017 285423 ON 7 G03454 (284017..285423) some similarities with uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress SAKL0G03476g 1 286264 288147 ON 7 G03476 (286264..288147) similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W SAC7 GTPase activating protein (GAP) for Rho1p involved in signaling to the actin cytoskeleton and similar to uniprot|Q12128 Saccharomyces cerevisiae YOR134W BAG7 Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis SAKL0G03498g 0 288428 290344 ON 7 G03498 complement(288428..290344) similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability SAKL0G03520g 1 290768 291877 ON 7 G03520 (290768..291877) highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle SAKL0G03542g 0 292214 293938 ON 7 G03542 complement(292214..293938) similar to uniprot|Q12212 Saccharomyces cerevisiae YOR137C SIA1 Suppressor of eIF5A High-copy suppressor of temperature-sensitive tif51A-1 SAKL0G03564g 0 294308 296125 ON 7 G03564 complement(294308..296125) similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1 SAKL0G03586g 1 297103 299664 ON 7 G03586 (297103..299664) some similarities with uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein required for normal cell surface assembly and flocculence SAKL0G03608g 0 299907 302291 ON 7 G03608 complement(299907..302291) similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes SAKL0G03630g 1 302684 303664 ON 7 G03630 (302684..303664) highly similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate Sklu_7.trna6G 0 303951 304021 ON 7 tG-CCC complement(303951..304021) tRNA Type: Gly (G) | Anti-Codon: CCC | Cove Score: 65.85 SAKL0G03674g 0 305150 306082 ON 7 G03674 complement(305150..306082) similar to uniprot|P35202 YOR143C Saccharomyces cerevisiae THI80 Thiamine pyrophosphokinase SAKL0G03696g 1 306241 307215 ON 7 G03696 (306241..307215) similar to uniprot|P06844 YDR392W Saccharomyces cerevisiae SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes SAKL0G03718g 0 307239 309659 ON 7 G03718 complement(307239..309659) similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Protein required for S phase progression and telomere homeostasis SAKL0G03740g 0 309922 310722 ON 7 G03740 complement(309922..310722) similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability SAKL0G03762g 1 311003 312724 ON 7 G03762 (311003..312724) similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology SAKL0G03784g 0 312858 313502 ON 7 G03784 complement(312858..313502) some similarities with uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Required for final stages of splicesome maturation promotes step 1 of splicing spliceosome-associated protein SAKL0G03806g 1 313650 314993 ON 7 G03806 (313650..314993) similar to Q04172 YDR393W uniprot|Q04172 Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology SAKL0G03828g 1 315123 316400 ON 7 G03828 (315123..316400) highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates substrate of N- acetyltransferase B SAKL0G03850g 0 316476 318002 ON 7 G03850 complement(316476..318002) similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure SAKL0G03872g 1 318245 321088 ON 7 G03872 (318245..321088) similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p SAKL0G03894g 0 321184 321764 ON 7 G03894 complement(321184..321623,321731..321764) highly similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) SAKL0G03916g 1 322002 323873 ON 7 G03916 (322002..323873) similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0G03938g 1 324696 325340 ON 7 G03938 (324696..325340) highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome SAKL0G03960g 0 325475 326914 ON 7 G03960 complement(325475..326914) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0G03982g 1 327372 328415 ON 7 G03982 (327372..328415) similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase) SAKL0G04004g 0 328456 330030 ON 7 G04004 complement(328456..330030) similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s SAKL0G04026g 1 331107 332699 ON 7 G04026 (331107..332699) similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor SAKL0G04048g 0 333201 333716 ON 7 G04048 complement(333201..333716) highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p SAKL0G04070g 1 334698 335183 ON 7 G04070 (334698..335183) highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit SAKL0G04092g 0 335372 339034 ON 7 G04092 complement(335372..339034) highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C RPB2 RNA polymerase II second largest subunit B150, part of central core SAKL0G04114g 1 339481 340221 ON 7 G04114 (339481..340221) similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit SAKL0G04136g 0 340527 341542 ON 7 G04136 complement(340527..341154,341460..341542) weakly similar to uniprot|Q99325 Saccharomyces cerevisiae YOR152C Hypothetical ORF SAKL0G04158g 0 341743 343035 ON 7 G04158 complement(341743..343035) similar to Q99312 YOR155C uniprot|Q99312 Saccharomyces cerevisiae ISN1 Inosine 5'-monophosphate (IMP)-specific 5'- nucleotidase SAKL0G04180g 1 343513 345135 ON 7 G04180 (343513..345135) similar to uniprot|Q12412 Saccharomyces cerevisiae YOR161C PNS1 SAKL0G04202g 0 345534 348431 ON 7 G04202 complement(345534..348431) similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor mediates the nuclear localization of proteins involved in mRNA-nucleus export SAKL0G04224g 1 349067 349351 ON 7 G04224 (349067..349351) highly similar to uniprot|Q12330 YOR159C Saccharomyces cerevisiae SME1 Required for pre-mRNA splicing, cap modification and U1 U2 U4 and U5 snRNA stability SAKL0G04246g 0 349497 350411 ON 7 G04246 complement(349497..350411) similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit PET123 exhibits genetic interactions with PET122 which encodes a COX3 mRNA-specific translational activator SAKL0G04268g 0 350553 354314 ON 7 G04268 complement(350553..354314) similar to Q04183 YDR407C uniprot|Q05731 Saccharomyces cerevisiae TRS120 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic SAKL0G04290g 1 354481 355266 ON 7 G04290 (354481..355266) highly similar to uniprot|P25043 YOR157C Saccharomyces cerevisiae PUP1 Endopeptidase with trypsin- like activity that cleaves after basic residues SAKL0G04312g 0 355364 356020 ON 7 G04312 complement(355364..356020) highly similar to uniprot|P04161 YDR408C Saccharomyces cerevisiae ADE8 Phosphoribosyl-glycinamide transformylase SAKL0G04334g 1 356470 359103 ON 7 G04334 (356470..359103) similar to Q04195 YDR409W uniprot|Q7LIJ4 Saccharomyces cerevisiae SIZ1 SUMO ligase that promotes the attachment of sumo (Smt3p small ubiquitin-related modifier) to proteins SAKL0G04356g 0 359196 359993 ON 7 G04356 complement(359196..359993) similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum localizes to the ER membrane SAKL0G04378g 0 360562 361353 ON 7 G04378 complement(360562..361353) similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting Sklu_7.trna7V 1 361531 361604 ON 7 tV-AAC (361531..361604) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0G04422g 0 362111 364057 ON 7 G04422 complement(362111..364057) similar to uniprot|P32796 YML042W Saccharomyces cerevisiae CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes SAKL0G04444g 0 364506 365501 ON 7 G04444 complement(364506..365501) similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1 SAKL0G04466g 1 366124 366837 ON 7 G04466 (366124..366837) similar to Q04031 YDR412W uniprot|Q04031 Saccharomyces cerevisiae RRP17 Protein required for cell viability SAKL0G04488g 0 366931 368076 ON 7 G04488 complement(366931..368076) similar to uniprot|P16151 Saccharomyces cerevisiae YDR414C ERD1 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins mutants secrete the endogenous ER protein BiP (Kar2p) SAKL0G04532g 0 369255 371078 ON 7 G04532 complement(369255..371078) similar to uniprot|Q04895 YIR028W Saccharomyces cerevisiae DAL4 Allantoin permease SAKL0G04554g 1 371907 373064 ON 7 G04554 (371907..373064) similar to uniprot|P32611 YEL050C Saccharomyces cerevisiae RML2 Mitochondrial ribosomal protein of the large subunit SAKL0G04576g 0 373252 374382 ON 7 G04576 complement(373252..374382) similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C Hypothetical ORF SAKL0G04598g 0 374593 375402 ON 7 G04598 complement(374593..375402) highly similar to uniprot|P32610 YEL051W Saccharomyces cerevisiae VMA8 vacuolar ATPase V1 domain subunit D SAKL0G04620g 1 376448 378922 ON 7 G04620 (376448..378922) similar to Q12309 YDR416W uniprot|Q04048 Saccharomyces cerevisiae CLF1 sssential splicesome assembly factor SAKL0G04642g 0 378974 380458 ON 7 G04642 complement(378974..380458) similar to uniprot|P32317 YEL052W Saccharomyces cerevisiae AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to mitochondria SAKL0G04664g 1 380826 383120 ON 7 G04664 (380826..383120) similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type SAKL0G04686g 0 383660 384475 ON 7 G04686 complement(383660..384475) similar to uniprot|Q2ZJS5 Caldicellulosiruptor saccharolyticus DSM 8903 CsacDRAFT_1700 Regulatory protein MerR SAKL0G04708g 1 385284 385781 ON 7 G04708 (385284..385781) highly similar to uniprot|P17079 Saccharomyces cerevisiae YEL054C RPL12A and highly similar to uniprot|P17079 Saccharomyces cerevisiae YDR418W RPL12B Protein component of the large (60S) ribosomal subunit SAKL0G04730g 1 386520 387422 ON 7 G04730 (386520..387422) conserved hypothetical protein SAKL0G04752g 1 387848 389743 ON 7 G04752 (387848..389743) similar to Q04049 YDR419W uniprot|Q04049 Saccharomyces cerevisiae RAD30 DNA polymerase eta involved in the predominantly error-free bypass replication of DNA lesions Sklu_7.trna8S 1 391804 391911 ON 7 tS-AGA (391804..391840,391867..391911) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 69.25 SAKL0G04862g 1 392107 399441 ON 7 G04862 (392107..399441) some similarities with uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif involved in the regulation of cell wall beta-1 3 glucan synthesis and bud site selection overexpression confers resistance to Hansenula mrakii killer toxin HM-1 SAKL0G04884g 1 400351 403143 ON 7 G04884 (400351..403143) similar to uniprot|Q04052 Saccharomyces cerevisiae YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids SAKL0G04906g 1 403654 405480 ON 7 G04906 (403654..405480) some similarities with uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function proposed to be involved in the RAS/cAMP signaling pathway SAKL0G04928g 0 405798 408476 ON 7 G04928 complement(405798..408476) some similarities with uniprot|P32578 Saccharomyces cerevisiae YDR422C SIP1 Alternate beta-subunit of the Snf1p kinase complex may confer substrate specificity vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions SAKL0G04950g 0 409365 411068 ON 7 G04950 complement(409365..411068) weakly similar to uniprot|P19880 YML007W Saccharomyces cerevisiae YAP1 bZip transcription factor required for oxidative stress tolerance SAKL0G04972g 1 411956 413083 ON 7 G04972 (411956..413083) similar to uniprot|P25087 YML008C Saccharomyces cerevisiae ERG6 Delta(24)-sterol C-methyltransferase SAKL0G04994g 1 413944 415608 ON 7 G04994 (413944..415608) weakly similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease mediates uptake of the phosphatidylinositol metabolite SAKL0G05016g 1 415990 417504 ON 7 G05016 (415990..417504) weakly similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning SAKL0G05038g 0 417526 417920 ON 7 G05038 complement(417526..417756,417823..417845,417911..417920) similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein SAKL0G05060g 1 418679 420694 ON 7 G05060 (418679..420694) some similarities with uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes SAKL0G05082g 1 420905 422089 ON 7 G05082 (420905..422089) highly similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W SAKL0G05104g 0 422194 422940 ON 7 G05104 complement(422194..422940) similar to uniprot|Q04066 Saccharomyces cerevisiae YDR428C Hypothetical ORF SAKL0G05126g 0 423140 423985 ON 7 G05126 complement(423140..423985) similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3) SAKL0G05148g 1 424575 424787 ON 7 G05148 (424575..424787) similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit SAKL0G05170g 0 425006 427990 ON 7 G05170 complement(425006..427990) similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation SAKL0G05192g 1 428218 428748 ON 7 G05192 (428218..428748) similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C Hypothetical ORF SAKL0G05214g 0 428810 429451 ON 7 G05214 complement(428810..429451) highly similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport SAKL0G05236g 0 429654 432614 ON 7 G05236 complement(429654..432614) highly similar to uniprot|P32898 Saccharomyces cerevisiae YDR430C CYM1 Cytosolic metalloprotease SAKL0G05258g 1 432822 433937 ON 7 G05258 (432822..433937) weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm SAKL0G05280g 0 434588 436429 ON 7 G05280 complement(434588..436429) similar to uniprot|Q04228 YML013W Saccharomyces cerevisiae SEL1 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p SAKL0G05302g 0 436887 437717 ON 7 G05302 complement(436887..437717) similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase SAKL0G05324g 1 438113 439648 ON 7 G05324 (438113..439648) similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins SAKL0G05346g 1 439849 441009 ON 7 G05346 (439849..441009) similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation SAKL0G05368g 0 441026 442030 ON 7 G05368 complement(441026..442030) similar to Q04081 YDR435C uniprot|Q04081 Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase SAKL0G05390g 1 442491 444455 ON 7 G05390 (442491..444455) similar to uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport SAKL0G05412g 1 444920 445405 ON 7 G05412 (444920..445405) similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability SAKL0G05434g 0 445684 447177 ON 7 G05434 complement(445684..447177) some similarities with uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing SAKL0G05456g 1 448553 449737 ON 7 G05456 (448553..449737) similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae Hypothetical ORF SAKL0G05478g 0 449974 450957 ON 7 G05478 complement(449974..450957) similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W SAKL0G05500g 1 451116 451874 ON 7 G05500 (451116..451874) some similarities with uniprot|Q04087 Saccharomyces cerevisiae YDR439W SAKL0G05522g 0 452056 454056 ON 7 G05522 complement(452056..454056) similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae Hypothetical ORF SAKL0G05544g 1 454660 455700 ON 7 G05544 (454660..455700) similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase SAKL0G05566g 1 455984 457711 ON 7 G05566 (455984..457711) similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase SAKL0G05588g 0 457858 458418 ON 7 G05588 complement(457858..458418) similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase SAKL0G05610g 1 458818 460473 ON 7 G05610 (458818..460473) similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability SAKL0G05632g 0 460540 464649 ON 7 G05632 complement(460540..464649) similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p- Srb11p kinase with RNA polymerase holoenzyme SAKL0G05654g 1 464824 466731 ON 7 G05654 (464824..466731) similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W Hypothetical ORF SAKL0G05676g 0 466855 468573 ON 7 G05676 complement(466855..468573) similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane Sklu_7.trna9K 0 469039 469111 ON 7 tK-CUU complement(469039..469111) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G05742g 1 470045 470908 ON 7 G05742 (470045..470908) weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure SAKL0G05764g 0 471119 471903 ON 7 G05764 complement(471119..471526,471901..471903) highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit SAKL0G05786g 1 472475 473782 ON 7 G05786 (472475..473782) highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes SAKL0G05808g 1 474519 475382 ON 7 G05808 (474519..475382) conserved hypothetical protein SAKL0G05830g 0 475503 476846 ON 7 G05830 complement(475503..476846) highly similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0G05852g 1 477497 478401 ON 7 G05852 (477497..477535,477625..478401) similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit SAKL0G05874g 1 479144 479980 ON 7 G05874 (479144..479190,479587..479980) highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and highly similar to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit SAKL0G05896g 0 480608 481768 ON 7 G05896 complement(480608..481768) similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate SAKL0G05918g 1 483079 485166 ON 7 G05918 (483079..485166) similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer SAKL0G05940g 0 485351 485944 ON 7 G05940 complement(485351..485944) highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase SAKL0G05962g 0 486270 488720 ON 7 G05962 complement(486270..488720) similar to uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two-hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing SAKL0G05984g 0 489003 489479 ON 7 G05984 complement(489003..489479) similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W SAKL0G06006g 0 490114 490671 ON 7 G06006 complement(490114..490671) highly similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase converts GMP to GDP required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins SAKL0G06028g 1 491223 493097 ON 7 G06028 (491223..493097) similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger SAKL0G06050g 0 493464 495311 ON 7 G06050 complement(493464..495311) similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains SAKL0G06072g 1 495701 497128 ON 7 G06072 (495701..497128) similar to uniprot|P06778 Saccharomyces cerevisiae YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA anneals complementary single-stranded DNA involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis SAKL0G06094g 1 498322 508107 ON 7 G06094 (498322..508107) similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus Sklu_YGOB_G04906 0 508754 508990 ON 7 G04906 complement(508754..508990 ANNOTATED BY YGOB - SAKL0G06116g 0 509472 512055 ON 7 G06116 complement(509472..510029,510103..512055) some similarities with uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1 and uniprot|Q03281 Saccharomyces cerevisiae YDR458C SAKL0G06138g 1 512307 514688 ON 7 G06138 (512307..514688) highly similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia may be involved in regulation of intracellular adenine nucleotide pools SAKL0G06160g 0 514850 515944 ON 7 G06160 complement(514850..515944) similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C likely functions in pathway(s) outside Ras SAKL0G06182g 1 516237 517169 ON 7 G06182 (516237..517169) similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W SAKL0G06204g 0 517155 517866 ON 7 G06204 complement(517155..517541,517609..517866) similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORFF SAKL0G06226g 1 518015 519313 ON 7 G06226 (518015..519313) weakly similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Hypothetical ORF Sklu_YGOB_YDR461C-A 0 519356 519589 ON 7 YDR461C-A complement(519356..519589) ANNOTATED BY YGOB - SAKL0G06248g 1 519956 520396 ON 7 G06248 (519956..520396) similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit SAKL0G06270g 1 521409 522602 ON 7 G06270 (521409..522602) similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8 SAKL0G06292g 1 522850 524403 ON 7 G06292 (522850..524403) uniprot|Q875P4 Saccharomyces kluyveri STP1 SAKL0G06314g 1 525076 530016 ON 7 G06314 (525076..530016) some similarities with uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 appears to control expression of spliceosome components PRP4 and PRP3 negative regulator of prp genes SAKL0G06336g 0 530348 531946 ON 7 G06336 complement(530348..531946) highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase catalyzes the C-14 demethylation of lanosterol to form 4 4''-dimethyl cholesta-8 14 24-triene-3-beta-ol in the ergosterol biosynthesis pathway member of the cytochrome P450 family SAKL0G06358g 0 532280 533479 ON 7 G06358 complement(532280..533479) similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine methyltransferase ribosomal protein L12 is a substrate SAKL0G06380g 0 533944 534624 ON 7 G06380 complement(533944..534624) similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Manganese-containing superoxide dismutase SAKL0G06402g 1 535632 537986 ON 7 G06402 (535632..537986) similar to uniprot|Q03306 Saccharomyces cerevisiae YDR466W SAKL0G06424g 0 538622 540016 ON 7 G06424 complement(538622..540016) similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C Hypothetical ORF SAKL0G06446g 0 541037 541672 ON 7 G06446 complement(541037..541672) similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 member of the syntaxin family of t-SNAREs tSNARE that affects a Late Golgi compartment SAKL0G06468g 1 541850 542146 ON 7 G06468 (541850..542146) some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W SAKL0G06490g 0 542280 543764 ON 7 G06490 complement(542280..543764) similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1 SAKL0G06512g 0 543956 544978 ON 7 G06512 complement(543956..544978) conserved hypothetical protein SAKL0G06534g 1 545615 546502 ON 7 G06534 (545615..545645,546123..546502) highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W RPL27A and to uniprot|P38706 Saccharomyces cerevisiae YDR471W RPL27B proteins component of the large (60S) ribosomal subunit SAKL0G06556g 1 546757 548088 ON 7 G06556 (546757..548088) similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase SAKL0G06578g 1 548318 549228 ON 7 G06578 (548318..548365,548437..549228) similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Protein involved in vacuolar protein sorting SAKL0G06600g 0 549492 551381 ON 7 G06600 complement(549492..551381) similar to uniprot|P39980 Saccharomyces cerevisiae YEL065W SIT1 Ferrioxamine B transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates transcription is induced during iron deprivation and diauxic shift potentially phosphorylated by Cdc28p SAKL0G06644g 0 552607 553296 ON 7 G06644 complement(552607..553296) similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing SAKL0G06666g 1 553454 554221 ON 7 G06666 (553454..554221) similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic SAKL0G06688g 1 554352 555239 ON 7 G06688 (554352..555239) conserved hypothetical protein Sklu_7.trna10S 0 556033 556140 ON 7 tS-AGA complement(556033..556077,556104..556140) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.26 SAKL0G06754g 1 557408 559117 ON 7 G06754 (557408..559117) similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Ada Histone acetyltransferase complex component protein of the Ada histone acetyltransferase complex SAKL0G06776g 1 559557 561560 ON 7 G06776 (559557..561560) similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Hypothetical ORF SAKL0G06798g 1 561718 562359 ON 7 G06798 (561718..562359) highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C SAKL0G06820g 0 562626 562853 ON 7 G06820 complement(562626..562853) some similarities with uniprot|Q3E824 Saccharomyces cerevisiae YOR020W-A, uncharacterized ORF SAKL0G06842g 1 563231 563551 ON 7 G06842 (563231..563551) highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co- chaperonin that inhibits the ATPase activity of Hsp60p SAKL0G06864g 0 563781 565478 ON 7 G06864 complement(563781..565478) similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor component of the U4/U6-U5 snRNP complex SAKL0G06886g 0 565523 567910 ON 7 G06886 complement(565523..567910) some similarities with uniprot|Q99248 Saccharomyces cerevisiae YOR019W SAKL0G06908g 0 568249 569100 ON 7 G06908 complement(568249..569100) conserved hypothetical protein SAKL0G06930g 0 569522 570154 ON 7 G06930 complement(569522..570154) weakly similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Hypothetical ORF SAKL0G06952g 1 570584 572383 ON 7 G06952 (570584..572383) similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 Protein serine/threonine kinase required for release from glucose repression invertase expression sporulation and for expression of catabolite-repressed genes when glucose is limiting regulates Adr1p-dependent transcription primarily at the level of chromatin binding SAKL0G06974g 1 572617 574251 ON 7 G06974 (572617..574251) similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst4p in telomeric silencing cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism SAKL0G06996g 1 574364 575044 ON 7 G06996 (574364..575044) some similarities with uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP which cleaves pre-rRNA not shared between Rnase MRP and nuclear Rnase P in contrast to all other Rnase MRP protein subunits binds to the NME1 RNA subunit of Rnase MRP SAKL0G07018g 0 575361 577139 ON 7 G07018 complement(575361..577139) similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p SAKL0G07040g 1 577213 578250 ON 7 G07040 (577213..578250) similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase delays anaphase in the presence of unattached kinetochores forms complexes with Mad1p-Bub1p and with Cdc20p binds Mad2p and Mad3p SAKL0G07062g 0 578306 579802 ON 7 G07062 complement(578306..579802) similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C SET7 Nuclear protein that contains a SET-domain which have been shown to mediate methyltransferase activity in other proteins SAKL0G07084g 1 580004 581761 ON 7 G07084 (580004..581761) highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase SAKL0G07106g 0 582144 584519 ON 7 G07106 complement(582144..584519) highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock prevents the aggregation of misfolded matrix proteins component of the mitochondrial proteolysis system SAKL0G07128g 0 585312 586133 ON 7 G07128 complement(585312..586133) some similarities with uniprot|P40917 Saccharomyces cerevisiae YOR028C CIN5 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance localizes constitutively to the nucleus and some similarities with uniprot|Q03935 Saccharomyces cerevisiae YDR259C YAP6 Basic leucine zipper (bZIP) transcription factor SAKL0G07150g 0 586356 586865 ON 7 G07150 complement(586356..586865) some similarities with uniprot|Q12379 Saccharomyces cerevisiae YDR260C SWM1 Spore Wall Maturation 1 SAKL0G07172g 0 587436 589079 ON 7 G07172 complement(587436..589079) similar to uniprot|P52911 YDR261C Saccharomyces cerevisiae EXG2 Exo-1 3-beta-glucanase involved in cell wall beta-glucan assembly SAKL0G07194g 1 589776 591308 ON 7 G07194 (589776..591308) weakly similar to uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein involved in invasive growth upon nitrogen starvation Sklu_7.trna11G 1 592694 592764 ON 7 tG-GCC (592694..592764) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0G07260g 1 592935 593885 ON 7 G07260 (592935..593885) weakly similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Hypothetical ORF SAKL0G07282g 0 594550 596904 ON 7 G07282 complement(594550..596904) some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant SAKL0G07304g 0 597163 599133 ON 7 G07304 complement(597163..599133) similar to uniprot|P39875 Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap-endonuclease involved in recombination double-strand break repair and DNA mismatch repair member of the Rad2p nuclease family with conserved N and I nuclease domains SAKL0G07326g 0 599477 601690 ON 7 G07326 complement(599477..601690) uniprot|Q875S9 Saccharomyces kluyveri AKR1 Palmitoyltransferase AKR1 SAKL0G07348g 0 602002 604212 ON 7 G07348 complement(602002..604212) similar to Saccharomyces cerevisiae uniprot|P51534 YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain binds to myosin motor domains to regulate myosin function involved in endocytosis polarization of the actin cytoskeleton and asymmetric mRNA localization SAKL0G07370g 1 604332 605365 ON 7 G07370 (604332..604383,604452..605365) similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import SAKL0G07392g 0 605436 607388 ON 7 G07392 complement(605436..607388) similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Hypothetical ORF SAKL0G07414g 1 607654 608291 ON 7 G07414 (607654..607851,607917..608291) similar to Saccharomyces cerevisiae YHR100C uniprot|P38812 Putative protein of unknown function, required for respiratory growth SAKL0G07436g 1 608515 609327 ON 7 G07436 (608515..609327) conserved hypothetical protein SAKL0G07458g 0 609418 620595 ON 7 G07458 complement(609418..620595) highly similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Histone acetyltransferase component putative ortholog of human TRRAP which is an essential cofactor of c-Myc SAKL0G07480g 0 621035 622549 ON 7 G07480 complement(621035..622549) similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol Sklu_7.trna12M 0 623648 623720 ON 7 tM-CAU complement(623648..623720) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 SAKL0G07524g 1 624810 626708 ON 7 G07524 (624810..626708) similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease located in the cytoplasm and endoplasmic reticulum SAKL0G07546g 1 627786 630515 ON 7 G07546 (627786..630515) similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Member of the Sec24p family forms a complex with Sec23p that is involved in sorting of Pma1p into COPII vesicles peripheral ER membrane protein potential Cdc28p substrate SAKL0G07568g 1 630838 632649 ON 7 G07568 (630838..631109,631353..632649) similar to uniprot|Q66RD5 Saccharomyces cerevisiae YDR348C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck potential Cdc28p substrate SAKL0G07590g 0 633002 633934 ON 7 G07590 complement(633002..633934) similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit MRP1 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator and with PET123 encoding a small subunit mitochondrial ribosomal protein SAKL0G07612g 1 634753 635964 ON 7 G07612 (634753..635964) similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways required for the diauxic growth shift expression in mammalian cells increases survival under conditions inducing apoptosis SAKL0G07634g 1 636596 639364 ON 7 G07634 (636596..639364) some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0G07656g 1 641127 642866 ON 7 G07656 (641127..642866) highly similar to Saccharomyces cerevisiae uniprot|P32466 YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions SAKL0G07678g 1 645867 647570 ON 7 G07678 (645867..647570) highly similar to uniprot|P39003 Saccharomyces cerevisiae YDR343C HXT6 High-affinity glucose transporter of the major facilitator superfamily nearly identical to Hxt7p expressed at high basal levels relative to other HXTs repression of expression by high glucose requires SNF3 SAKL0G07700g 0 648071 649342 ON 7 G07700 complement(648071..649342) no similarity SAKL0G07722g 1 649984 651939 ON 7 G07722 (649984..651939) highly similar to uniprot|Q05506 Saccharomyces cerevisiae YDR341C Cytoplasmic arginyl-tRNA synthetase Sklu_7.trna13S 1 652483 652585 ON 7 tS-GCU (652483..652519,652541..652585) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 67.91 SAKL0G07766g 1 652944 653513 ON 7 G07766 (652944..653513) highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C Protein required for cell viability SAKL0G07788g 0 653573 654133 ON 7 G07788 complement(653573..654133) weakly similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF SAKL0G07810g 1 654509 655324 ON 7 G07810 (654509..655324) similar to uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Yeast homolog of mammalian Ing1 NuA4 histone acetyltransferase complex component SAKL0G07832g 1 656128 658200 ON 7 G07832 (656128..658200) similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF SAKL0G07854g 1 659051 660517 ON 7 G07854 (659051..660517) conserved hypothetical protein SAKL0G07876g 0 660605 661474 ON 7 G07876 complement(660605..661474) similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit SAKL0G07898g 0 661831 665022 ON 7 G07898 complement(661831..665022) conserved hypothetical protein SAKL0G07920g 1 665931 666602 ON 7 G07920 (665931..666602) some similarities with uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex involved in the modification and cleavage of the 18S pre-rRNA SAKL0G07942g 0 666743 667843 ON 7 G07942 complement(666743..667843) some similarities with uniprot|Q05473 Saccharomyces cerevisiae YDR336W Hypothetical ORF SAKL0G07964g 0 668256 671921 ON 7 G07964 complement(668256..671921) highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p Far1p and Pho4p cargo dissociation involves binding to RanGTP SAKL0G07986g 0 672170 673051 ON 7 G07986 complement(672170..673051) highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit contains a sigma(70)-like motif which is thought to bind RNA SAKL0G08008g 0 673391 678040 ON 7 G08008 complement(673391..678040) highly similar to uniprot|P33302 Saccharomyces cerevisiae YOR153W PDR5 Short-lived membrane ABC (ATP- binding cassette) transporter actively exports various drugs expression regulated by Pdr1p also involved in steroid transport cation resistance and cellular detoxification during exponential growth SAKL0G08030g 1 678831 681125 ON 7 G08030 (678831..681125) conserved hypothetical protein SAKL0G08052g 0 681957 682298 ON 7 G08052 complement(681957..682298) similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W Hypothetical ORF SAKL0G08074g 0 682964 687379 ON 7 G08074 complement(682964..687379) some similarities with uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase component of the SWR1 complex required for the incorporation of Htz1p into chromatin SAKL0G08096g 0 687959 688906 ON 7 G08096 complement(687959..688906) weakly similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF SAKL0G08118g 0 689908 691545 ON 7 G08118 complement(689908..691545) similar to uniprot|Q759G9 Ashbya gossypii ADR307W ADR307Wp and some similarites with YHR086W uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein component of the U1 snRNP protein mutants are defective in meiotic recombination and in formation of viable spores involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA SAKL0G08140g 0 692376 693443 ON 7 G08140 complement(692376..693443) similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Protein of unknown function essential for viability may be involved in rRNA processing SAKL0G08162g 1 693726 695903 ON 7 G08162 (693726..695903) similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Hypothetical ORF SAKL0G08184g 0 696068 698284 ON 7 G08184 complement(696068..698284) similar to uniprot|P13574 Saccharomyces cerevisiae YHR084W STE12 Transcription factor that is activated by a MAP kinase signaling cascade activates genes involved in mating or pseudohyphal/invasive growth pathways cooperates with Tec1p transcription factor to regulate genes specific for invasive growth SAKL0G08206g 0 698750 699706 ON 7 G08206 complement(698750..699706) similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex aka TOB complex) of the mitochondrial outer membrane which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane SAKL0G08228g 0 700095 702248 ON 7 G08228 complement(700095..702248) similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W Hypothetical ORF SAKL0G08250g 1 703212 705707 ON 7 G08250 (703212..705707) similar to uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role overproduction causes allele-specific suppression of the prp20-10 mutation SAKL0G08272g 0 706154 707464 ON 7 G08272 complement(706154..707464) similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins SAKL0G08294g 0 707519 708958 ON 7 G08294 complement(707519..708958) similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p SAKL0G08316g 0 709133 709687 ON 7 G08316 complement(709133..709687) similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs homolog of mammalian nuclear matrix protein C1D which is involved in regulation of DNA repair and recombination SAKL0G08338g 1 709938 710396 ON 7 G08338 (709938..710396) conserved hypothetical protein SAKL0G08360g 1 710623 711987 ON 7 G08360 (710623..711987) similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 peroxisomal membrane protein SAKL0G08382g 1 712407 712952 ON 7 G08382 (712407..712952) highly similar to uniprot|Q759H8 Ashbya gossypii ADR295C ADR295Cp and similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 evolutionarily conserved kinetochore protein that is part of multiple protein complexes SAKL0G08404g 1 713432 717427 ON 7 G08404 (713432..717427) similar to uniprot|Q06681 Saccharomyces cerevisiae YDR326C Hypothetical ORF SAKL0G08426g 1 717659 718011 ON 7 G08426 (717659..717763,717847..718011) similar to uniprot|P89114 Saccharomyces cerevisiae YHR079C-A Meiosis specific protein involved in DMC1- dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p SAKL0G08448g 1 718250 721717 ON 7 G08448 (718250..721717) similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing SAKL0G08470g 0 721802 725005 ON 7 G08470 complement(721802..725005) similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Yeast Condensin G SAKL0G08492g 1 725684 727894 ON 7 G08492 (725684..727894) similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0G08514g 0 728072 729670 ON 7 G08514 complement(728072..729670) similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W Hypothetical ORF SAKL0G08536g 1 729806 731407 ON 7 G08536 (729806..731407) similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high- fidelity vesicle docking and fusion which are essential for targeting of vesicles to the endosome required for vacuole inheritance SAKL0G08558g 1 732678 735872 ON 7 G08558 (732678..732683,732771..735872) similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway interacts with Nam7p and Upf3p SAKL0G08580g 0 735894 736961 ON 7 G08580 complement(735894..736961) similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Mitochondrially localized type 2C protein phosphatase expression induced by growth on ethanol and by sustained osmotic stress possible role in carbon source utilization in low oxygen environments SAKL0G08602g 1 737236 737514 ON 7 G08602 (737236..737514) similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric state of ATP synthase SAKL0G08624g 0 737815 738885 ON 7 G08624 complement(737815..738885) similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit SAKL0G08646g 1 741442 744099 ON 7 G08646 (741442..744099) weakly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase SAKL0G08668g 1 744474 745610 ON 7 G08668 (744474..745610) similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein SAKL0G08690g 0 745720 747873 ON 7 G08690 complement(745720..747873) highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD( ) synthetase essential for the formation of NAD( ) from nicotinic acid adenine dinucleotide SAKL0G08712g 0 748056 749111 ON 7 G08712 complement(748056..749111) conserved hypothetical protein SAKL0G08734g 0 749632 750756 ON 7 G08734 complement(749632..750756) highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism SAKL0G08756g 0 751052 753967 ON 7 G08756 complement(751052..753967) similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability SAKL0G08778g 1 754471 754689 ON 7 G08778 (754471..754689) highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore SAKL0G08800g 0 754882 755061 ON 7 G08800 complement(754882..755061) highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA SAKL0G08822g 1 755393 757141 ON 7 G08822 (755393..757141) similar to gnl|GLV|KLLA0B10197g Kluyveromyces lactis KLLA0B10197g and some similarites with YDR320C uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin- like protein SAKL0G08844g 0 757226 759466 ON 7 G08844 complement(757226..759466) highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3- epoxide a step in ergosterol biosynthesis SAKL0G08866g 1 759588 760355 ON 7 G08866 (759588..760355) weakly similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Hypothetical ORF SAKL0G08888g 0 760335 761539 ON 7 G08888 complement(760335..761422,761488..761539) similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules SAKL0G08910g 0 761626 763143 ON 7 G08910 complement(761626..763143) weakly similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W Hypothetical ORF SAKL0G08998g 0 778100 778774 ON 7 G08998 complement(778100..778774) conserved hypothetical protein SAKL0G09064g 0 781359 781739 ON 7 G09064 complement(781359..781739) some similarities with uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase Sklu_7.trna14F 1 782900 782992 ON 7 tF-GAA (782900..782936,782957..782992) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.92 SAKL0G09108g 0 783281 783982 ON 7 G09108 complement(783281..783982) similar to uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity SAKL0G09130g 0 784892 786397 ON 7 G09130 complement(784892..786397) similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya SAKL0G09152g 1 786620 787687 ON 7 G09152 (786620..787687) highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p). SAKL0G09174g 0 787771 789180 ON 7 G09174 complement(787771..789180) similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane has a conserved methyltransferase motif multicopy suppressor of respiratory defects caused by OXA1 mutations SAKL0G09196g 0 789596 790759 ON 7 G09196 complement(789596..790759) highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric SAKL0G09218g 1 790844 791737 ON 7 G09218 (790844..791737) similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6-pentakisphosphate 2-kinase nuclear protein required for synthesis of 1 2 3 4 5 6- hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable SAKL0G09240g 0 791734 792552 ON 7 G09240 complement(791734..792552) weakly similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl- thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology SAKL0G09262g 1 792658 794652 ON 7 G09262 (792658..794652) similar to uniprot|Q06665 Saccharomyces cerevisiae YDR314C Hypothetical ORF SAKL0G09284g 1 795241 796131 ON 7 G09284 (795241..796131) similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)- phosphate contains a FYVE finger domain SAKL0G09306g 0 796294 797616 ON 7 G09306 complement(796294..797616) similar to uniprot|Q12153 Saccharomyces cerevisiae YDR312W SSF2 high copy suppressor of G beta subunit temperature sensitive mutation possibly involved in mating SAKL0G09328g 1 797795 799312 ON 7 G09328 (797795..799312) highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF-4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA SAKL0G09350g 1 800005 800223 ON 7 G09350 (800005..800223) no similarity SAKL0G09372g 1 800578 801189 ON 7 G09372 (800578..801189) no similarity SAKL0G09394g 0 802262 804121 ON 7 G09394 complement(802262..804121) similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators SAKL0G09416g 1 804704 806323 ON 7 G09416 (804704..806323) similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein SAKL0G09438g 1 806738 807931 ON 7 G09438 (806738..807931) similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE SAKL0G09460g 1 809568 812267 ON 7 G09460 (809568..812267) some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppresor of mar1-1 (sir2) mutation nuclear protein involved in silencing SAKL0G09482g 1 812616 813530 ON 7 G09482 (812616..813530) similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0G09504g 1 814085 814558 ON 7 G09504 (814085..814558) no similarity SAKL0G09526g 1 815058 816194 ON 7 G09526 (815058..816194) weakly similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac- interactive binding (CRIB) domain SAKL0G09548g 0 816413 816964 ON 7 G09548 complement(816413..816964) similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex SAKL0G09570g 1 817113 817562 ON 7 G09570 (817113..817562) highly similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component SAKL0G09592g 0 817653 819614 ON 7 G09592 complement(817653..819614) weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF SAKL0G09614g 1 820051 822357 ON 7 G09614 (820051..822357) conserved hypothetical protein Sklu_7.trna15V 1 822827 822899 ON 7 tV-CAC (822827..822899) tRNA Type: Val (V) | Anti-Codon: CAC | Cove Score: 75.70 SAKL0G09658g 1 823183 824493 ON 7 G09658 (823183..824493) similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF SAKL0G09680g 1 824883 825504 ON 7 G09680 (824883..824936,824998..825504) similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase SAKL0G09702g 0 825589 825996 ON 7 G09702 complement(825589..825996) similar to uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin SAKL0G09724g 1 826318 827097 ON 7 G09724 (826318..827097) similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit SAKL0G09746g 1 827221 827946 ON 7 G09746 (827221..827946) similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER SAKL0G09768g 1 828604 830937 ON 7 G09768 (828604..830937) similar to uniprot|Q06639 Saccharomyces cerevisiae YDR303C RSC3 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p SAKL0G09790g 1 831141 831965 ON 7 G09790 (831141..831965) conserved hypothetical protein SAKL0G09812g 0 832000 832725 ON 7 G09812 complement(832000..832725) similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog ; GPI11 ER membrane protein SAKL0G09834g 0 833686 837639 ON 7 G09834 complement(833686..837639) similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I) SAKL0G09856g 1 837830 839086 ON 7 G09856 (837830..839086) highly similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF SAKL0G09878g 0 839132 840190 ON 7 G09878 complement(839132..840190) similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p) SAKL0G09900g 1 840397 842019 ON 7 G09900 (840397..842019) weakly similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF SAKL0G09922g 0 842183 843790 ON 7 G09922 complement(842183..843790) similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A SAKL0G09944g 1 844860 845480 ON 7 G09944 (844860..845480) highly similar to gnl|GLV|KLLA0C10384g Kluyveromyces lactis KLLA0C10384g uniprot|O74190 ATP5 ATP synthase subunit 5 mitochondrial precursor and similar to YDR298C uniprot|P09457 Saccharomyces cerevisiae YDR298C ATP5 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein) SAKL0G09966g 0 846059 847090 ON 7 G09966 complement(846059..847090) similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine SAKL0G09988g 0 847730 848386 ON 7 G09988 complement(847730..848386) similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning SAKL0G10010g 1 848643 850694 ON 7 G10010 (848643..850694) similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF SAKL0G10032g 1 851284 853260 ON 7 G10032 (851284..853260) similar to uniprot|Q06629 Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda3p; Ploidy-related SAKL0G10054g 1 853800 855542 ON 7 G10054 (853800..855542) similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate SAKL0G10076g 1 855625 856971 ON 7 G10076 (855625..856971) similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability SAKL0G10098g 1 857700 859421 ON 7 G10098 (857700..859421) highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase SAKL0G10120g 1 860135 861967 ON 7 G10120 (860135..861967) conserved hypothetical protein SAKL0G10142g 1 862958 866707 ON 7 G10142 (862958..866707) similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence SAKL0G10164g 0 867445 869139 ON 7 G10164 complement(867445..869139) uniprot|Q6W9G6 Saccharomyces kluyveri PDC11 Pyruvate decarboxylase SAKL0G10186g 1 869702 870400 ON 7 G10186 (869702..870400) similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor SAKL0G10208g 0 870528 872465 ON 7 G10208 complement(870528..872465) similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids SAKL0G10230g 0 872780 873208 ON 7 G10230 complement(872780..873121,873206..873208) similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector SAKL0G10252g 1 873555 874640 ON 7 G10252 (873555..874640) similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA SAKL0G10274g 0 874738 876306 ON 7 G10274 complement(874738..876306) weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria SAKL0G10296g 1 876462 878243 ON 7 G10296 (876462..878243) similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP- dependent protein targeting interacts with SRP102p SAKL0G10318g 0 878346 881582 ON 7 G10318 complement(878346..881582) highly similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF SAKL0G10340g 1 881702 882802 ON 7 G10340 (881702..882802) similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition SAKL0G10362g 0 882854 883604 ON 7 G10362 complement(882854..883478,883543..883604) similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit SAKL0G10384g 0 883824 888848 ON 7 G10384 complement(883824..888848) similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha- subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex SAKL0G10406g 0 889109 890008 ON 7 G10406 complement(889109..890008) similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc-regulated vacuolar membrane-associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism Sklu_YGOB_Anc_5.296 1 891742 892812 ON 7 Anc_5.296 (891742..892812) ANNOTATED BY YGOB - SAKL0G10450g 0 892884 893222 ON 7 G10450 complement(892884..893222) similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF Sklu_7.trna16Q 1 894744 894815 ON 7 tQ-UUG (894744..894815) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0G10516g 1 895476 896354 ON 7 G10516 (895476..896354) highly similar to uniprot|Q05533 Saccharomyces cerevisiae YDR287W inositol monophosphatase SAKL0G10538g 1 896896 897816 ON 7 G10538 (896896..897816) similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential protein of unknown function SAKL0G10560g 1 898009 900090 ON 7 G10560 (898009..900090) similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase involved in ergosterol biosynthesis associated and coordinately regulated with Erg11p SAKL0G10582g 1 900403 901554 ON 7 G10582 (900403..901554) similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF SAKL0G10604g 0 901652 902383 ON 7 G10604 complement(901652..902383) similar to uniprot|P38773 Saccharomyces cerevisiae and to YHR044C uniprot|P38774 Saccharomyces cerevisiae DOG1 2- deoxyglucose-6-phosphate phosphatase SAKL0G10626g 1 903030 903638 ON 7 G10626 (903030..903638) no similarity SAKL0G10648g 0 903727 904644 ON 7 G10648 complement(903727..904644) highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'- >5' exonucleases SAKL0G10670g 0 904915 905946 ON 7 G10670 complement(904915..905946) similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity SAKL0G10692g 1 906252 907949 ON 7 G10692 (906252..907949) similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF SAKL0G10714g 0 908030 908929 ON 7 G10714 complement(908030..908929) highly similar to uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase involved in biosynthesis of inositol and in phosphoinositide second messenger signaling INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate SAKL0G10736g 0 909633 912212 ON 7 G10736 complement(909633..912212) highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase SAKL0G10758g 1 913417 915018 ON 7 G10758 (913417..915018) similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W Hypothetical ORF SAKL0G10780g 1 915483 916202 ON 7 G10780 (915483..916202) highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W SAKL0G10802g 1 916549 918123 ON 7 G10802 (916549..918123) similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter SAKL0G10824g 1 918344 918937 ON 7 G10824 (918344..918937) similar to uniprot|P36054 Saccharomyces cerevisiae YKL159C SAKL0G10846g 1 919242 919688 ON 7 G10846 (919242..919688) highly similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain expression is regulated by oxygen levels SAKL0G10868g 0 920028 920492 ON 7 G10868 complement(920028..920492) similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Protein of unknown function deletion inhibits Brome mosaic virus expression SAKL0G10890g 1 920736 922055 ON 7 G10890 (920736..922055) similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Core interacting component 1 ribosome biogenesis protein SAKL0G10912g 1 922534 923547 ON 7 G10912 (922534..923547) conserved hypothetical protein SAKL0G10934g 0 923876 925708 ON 7 G10934 complement(923876..925708) similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF SAKL0G10956g 1 926115 928325 ON 7 G10956 (926115..928325) similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition structurally and functionally related to Pif1p SAKL0G10978g 1 929164 930729 ON 7 G10978 (929164..930729) highly similar to uniprot|Q00772 Saccharomyces cerevisiae YHR030C SLT2 Suppressor of lyt2 serine/threonine MAP kinase SAKL0G11000g 1 931981 934449 ON 7 G11000 (931981..934449) similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C SAKL0G11022g 1 935030 937957 ON 7 G11022 (935030..937957) similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain a site for protein?protein interactions SAKL0G11044g 0 938203 938841 ON 7 G11044 complement(938203..938841) similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole SAKL0G11066g 0 939359 940432 ON 7 G11066 complement(939359..940432) highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 homoserine kinase SAKL0G11088g 1 940673 942157 ON 7 G11088 (940673..942157) similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins SAKL0G11110g 0 942330 947945 ON 7 G11110 complement(942330..947945) similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain required for wild- type cytokinesis and cell separation localizes to the actomyosin ring binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively SAKL0G11132g 1 948460 950391 ON 7 G11132 (948460..950391) conserved hypothetical protein SAKL0G11154g 1 951384 952457 ON 7 G11154 (951384..952457) weakly similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C SAKL0G11176g 1 953060 953771 ON 7 G11176 (953060..953062,953526..953771) highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021c RPS27B ribosomal protein and to uniprot|P35997 Saccharomyces cerevisiae YKL156w RPS27A, Protein component of the small (40S) ribosomal subunit SAKL0G11198g 0 953975 956152 ON 7 G11198 complement(953975..956152) similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit SAKL0G11220g 1 956374 957206 ON 7 G11220 (956374..956550,956613..957206) similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit involved in SRP-dependent protein targeting anchors Srp101p to the ER membrane. Sklu_YGOB_YIL102C-A 0 957292 957489 ON 7 YIL102C-A complement(957292..957489) ANNOTATED BY YGOB - Sklu_7.trna17R 1 957632 957703 ON 7 tR-UCU (957632..957703) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0G11264g 1 958177 963153 ON 7 G11264 (958177..963153) similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC) localizes to the nuclear periphery of nuclear pores homologous to human p205 SAKL0G11286g 0 963289 965887 ON 7 G11286 complement(963289..965792,965887..965887) similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export SAKL0G11308g 0 966360 970562 ON 7 G11308 complement(966360..970562) similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase SAKL0G11330g 1 971192 972313 ON 7 G11330 (971192..972313) weakly similar to uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member Ypt6p involved in vesicle mediated protein transport SAKL0G11352g 0 972393 973136 ON 7 G11352 complement(972393..973136) highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway converts 3-phosphoglycerate to 2- phosphoglycerate SAKL0G11374g 0 973599 974576 ON 7 G11374 complement(973599..974576) similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Hypothetical ORF SAKL0G11396g 1 974755 975672 ON 7 G11396 (974755..975672) similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase involved in ergosterol biosynthesis SAKL0G11418g 0 975876 977168 ON 7 G11418 complement(975876..977168) similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme involved in intron turnover required for efficient Ty1 transposition SAKL0G11440g 0 977610 980030 ON 7 G11440 complement(977610..980030) highly similar to uniprot|Q00711 Saccharomyces cerevisiae YKL148C SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone SAKL0G11462g 1 980180 982030 ON 7 G11462 (980180..982030) similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters SAKL0G11484g 1 982362 983857 ON 7 G11484 (982362..982478,982604..983857) highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for optimal CDC20 transcription interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p SAKL0G11506g 0 983969 984601 ON 7 G11506 complement(983969..984601) highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25 SAKL0G11528g 1 985074 986519 ON 7 G11528 (985074..986519) similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Protein required for growth at low temperature SAKL0G11550g 1 986891 987544 ON 7 G11550 (986891..987544) similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W SAKL0G11572g 0 987737 989761 ON 7 G11572 complement(987737..989761) similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C Protein required for cell viability SAKL0G11594g 0 989965 991662 ON 7 G11594 complement(989965..991662) highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo Sklu_7.trna18M 1 992687 992759 ON 7 tM-CAU (992687..992759) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 SAKL0G11660g 1 992953 995376 ON 7 G11660 (992953..995376) similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Required for Vacuolar Protein Sorting Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p. SAKL0G11682g 0 995430 996026 ON 7 G11682 complement(995430..996026) highly similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex which delays the onset of anaphase in cells with defects in mitotic spindle assembly forms a complex with Mad1p SAKL0G11704g 1 996184 997228 ON 7 G11704 (996184..996186,996248..997228) highly similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p SAKL0G11726g 0 997244 998242 ON 7 G11726 complement(997244..998242) highly similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C SAKL0G11748g 0 998525 1000816 ON 7 G11748 complement(998525..1000816) highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis SAKL0G11770g 1 1001060 1001704 ON 7 G11770 (1001060..1001704) similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C Hypothetical ORF SAKL0G11792g 0 1001826 1003865 ON 7 G11792 complement(1001826..1003865) highly similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p SAKL0G11814g 1 1004229 1004990 ON 7 G11814 (1004229..1004990) similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p SAKL0G11836g 0 1005013 1006287 ON 7 G11836 complement(1005013..1006287) similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin SAKL0G11858g 0 1007034 1009625 ON 7 G11858 complement(1007034..1009625) weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)- anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner SAKL0G11880g 0 1015266 1016762 ON 7 G11880 complement(1015266..1016762) similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2) SAKL0G11902g 1 1016915 1019635 ON 7 G11902 (1016915..1019635) similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p Sklu_7.trna19S 1 1020520 1020627 ON 7 tS-AGA (1020520..1020556,1020583..1020627) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 72.39 SAKL0G11968g 0 1020952 1021977 ON 7 G11968 complement(1020952..1021977) highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13 SAKL0G11990g 1 1024218 1024652 ON 7 G11990 (1024218..1024652) weakly similar to uniprot|Q07921 Saccharomyces cerevisiae YLR010C TEN1 protein involved in Telomeric pathways in association with Stn1; Protein required for cell viability SAKL0G12012g 1 1024819 1026108 ON 7 G12012 (1024819..1026108) conserved hypothetical protein SAKL0G12034g 0 1026266 1026856 ON 7 G12034 complement(1026266..1026856) similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Ribosomal Like Protein 24 SAKL0G12056g 1 1027223 1027717 ON 7 G12056 (1027223..1027717) similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the mitochondrial import motor associated with the presequence translocase along with Ssc1p Tim44p Mge1p and Pam16p stimulates the ATPase activity of Ssc1p to drive mitochondrial import contains a J domain SAKL0G12078g 0 1027844 1028794 ON 7 G12078 complement(1027844..1028794) similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential nuclear protein required for DNA repair forms a complex with Smc5p and Rhc18p SAKL0G12100g 1 1029250 1031466 ON 7 G12100 (1029250..1031466) weakly similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism dephosphorylated form is degraded by the ubiquitin-proteasome system potential Cdc28p substrate SAKL0G12122g 1 1031981 1034077 ON 7 G12122 (1031981..1034077) similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 beta-adaptin large subunit of the clathrin- associated protein complex SAKL0G12144g 0 1034186 1035091 ON 7 G12144 complement(1034186..1035091) similar to Q07897 YLR003C uniprot|Q07897 Saccharomyces cerevisiaeCMS1 Hypothetical ORF SAKL0G12166g 0 1035355 1036980 ON 7 G12166 complement(1035355..1036980) highly similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF SAKL0G12188g 1 1037479 1040127 ON 7 G12188 (1037479..1040127) conserved hypothetical protein SAKL0G12210g 1 1040432 1041868 ON 7 G12210 (1040432..1041868) similar to uniprot|Q04673 YLR005W Saccharomyces cerevisiae SSL1 Component of RNA polymerase transcription factor TFIIH SAKL0G12232g 1 1042473 1044263 ON 7 G12232 (1042473..1044263) highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C SAKL0G12254g 1 1044636 1046381 ON 7 G12254 (1044636..1046381) highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C Sklu_7.trna20K 1 1047569 1047641 ON 7 tK-CUU (1047569..1047641) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G12320g 1 1048341 1050401 ON 7 G12320 (1048341..1050401) some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells binds to Aga1p during agglutination N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin C-terminal half is highly glycosylated and contains GPI anchor SAKL0G12342g 1 1050736 1052274 ON 7 G12342 (1050736..1052274) similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Hypothetical ORF SAKL0G12364g 1 1052416 1053090 ON 7 G12364 (1052416..1053090) similar to uniprot|P39975 Saccharomyces cerevisiae YEL072W RMD6 Protein required for sporulation SAKL0G12386g 0 1053155 1053808 ON 7 G12386 complement(1053155..1053808) conserved hypothetical protein SAKL0G12408g 1 1054059 1056047 ON 7 G12408 (1054059..1056047) similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport also binds to chromatin to promote the association of DNA replication factors and replication initiation SAKL0G12430g 0 1056146 1057960 ON 7 G12430 complement(1056146..1057960) weakly similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W SAKL0G12452g 0 1058250 1060058 ON 7 G12452 complement(1058250..1060058) similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters SAKL0G12474g 0 1060462 1061016 ON 7 G12474 complement(1060462..1061016) conserved hypothetical protein SAKL0G12496g 1 1061243 1063948 ON 7 G12496 (1061243..1063948) similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Hypothetical ORF Sklu_CEN7 0 1064371 1064569 ON 7 CEN7 complement(1064371..1064569) Chromosome VII centromere SAKL0G12540g 0 1068078 1070399 ON 7 G12540 complement(1068078..1070399) similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur also participates in endocytosis SAKL0G12562g 0 1070935 1072269 ON 7 G12562 complement(1070935..1072269) similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Regulator of Ty1 Transposition Regulation of mitochondrial network Killed in Mutagen sensitive to diepoxybutane and/or mitomycin C diepoxybutane and mitomycin C resistance SAKL0G12584g 0 1072410 1073137 ON 7 G12584 complement(1072410..1072992,1073073..1073137) similar to uniprot|P38624 Saccharomyces cerevisiae YJL001W PRE3 20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides SAKL0G12606g 0 1073457 1076384 ON 7 G12606 complement(1073457..1076384) weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1 SAKL0G12628g 1 1076578 1077987 ON 7 G12628 (1076578..1077987) similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins SAKL0G12650g 0 1078086 1079969 ON 7 G12650 complement(1078086..1079969) similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing SAKL0G12672g 0 1080840 1081196 ON 7 G12672 complement(1080840..1081196) highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase SAKL0G12694g 1 1081452 1084490 ON 7 G12694 (1081452..1084490) some similarities with uniprot|Q07798 Saccharomyces cerevisiae YLL005C SPO75 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis SAKL0G12716g 0 1084608 1085972 ON 7 G12716 complement(1084608..1085972) similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids SAKL0G12738g 1 1086223 1088208 ON 7 G12738 (1086223..1088208) similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Hypothetical ORF SAKL0G12760g 0 1088344 1090557 ON 7 G12760 complement(1088344..1090557) similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function including synthesis of 60S ribosomal subunits SAKL0G12782g 1 1090783 1091364 ON 7 G12782 (1090783..1091364) similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Multicopy suppressor of ypt6 null mutation SAKL0G12804g 0 1091709 1097228 ON 7 G12804 complement(1091709..1097228) uniprot|P23466 Saccharomyces kluyveri CYR1 Adenylate cyclase Sklu_YGOB_Anc_5.205 1 1097509 1097697 ON 7 Anc_5.205 (1097509..1097697) ANNOTATED BY YGOB - SAKL0G12826g 1 1097824 1098834 ON 7 G12826 (1097824..1098834) highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP) catalyzes the initial step in the methionine salvage pathway affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity regulates ADH2 gene expression SAKL0G12848g 0 1098900 1100159 ON 7 G12848 complement(1098900..1100159) weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 nuclear pore integral membrane protein SAKL0G12870g 1 1100535 1101734 ON 7 G12870 (1100535..1101734) similar to uniprot|Q07800 Saccharomyces cerevisiae YLL010C SAKL0G12892g 0 1102157 1103587 ON 7 G12892 complement(1102157..1103587) highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W SAKL0G12914g 0 1103755 1105365 ON 7 G12914 complement(1103755..1105365) similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C YEH2 Steryl ester hydrolase catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism SAKL0G12936g 1 1105502 1106041 ON 7 G12936 (1105502..1106041) similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W Hypothetical ORF SAKL0G12958g 0 1106073 1106807 ON 7 G12958 complement(1106073..1106807) highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Protein required for cell viability SAKL0G12980g 0 1108751 1110442 ON 7 G12980 complement(1108751..1110442) some similarities with uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc metabolism member of the four-protein IZH family expression induced by zinc deficiency deletion reduces sensitivity to elevated zinc and shortens lag phase overexpression reduces Zap1p activity SAKL0G13002g 1 1111122 1113485 ON 7 G13002 (1111122..1113485) some similarities with uniprot|Q02601 Saccharomyces cerevisiae YLL013C PUF3 member of the PUF protein family which is named for the founding members PUmilio and Fbf SAKL0G13024g 0 1113718 1114041 ON 7 G13024 complement(1113718..1114041) similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W Hypothetical ORF SAKL0G13046g 1 1114311 1115477 ON 7 G13046 (1114311..1115477) similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C SAKL0G13068g 0 1115576 1117621 ON 7 G13068 complement(1115576..1117621) weakly similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF) interacts with Fcp1p phosphatase and with TFIIB potentially phosphorylated by Cdc28p SAKL0G13090g 1 1118998 1120227 ON 7 G13090 (1118998..1120227) highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 tyrosyl-tRNA synthetase cytoplasmic SAKL0G13112g 0 1120334 1125880 ON 7 G13112 complement(1120334..1125880) similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3) SAKL0G13134g 1 1127910 1133723 ON 7 G13134 (1127910..1133723) similar to uniprot|P19812 Saccharomyces cerevisiae YGR184C UBR1 Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway binds to the Rpn2p Rpt1p and Rpt6p proteins of the 19S particle of the 26S proteasome SAKL0G13156g 1 1134001 1134766 ON 7 G13156 (1134001..1134003,1134563..1134766) similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex SAKL0G13178g 0 1135180 1135491 ON 7 G13178 complement(1135180..1135491) similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Translocase of the inner membrane mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins Subunit of mitochondrial protein import machinery Sklu_7.trna21G 1 1135645 1135715 ON 7 tG-GCC (1135645..1135715) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0G13222g 1 1135994 1136645 ON 7 G13222 (1135994..1136015,1136080..1136645) similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3 which is involved in vacuolar protein sorting related to the sigma subunit of the mammalian clathrin AP-3 complex suppressor of loss of casein kinase 1 function SAKL0G13244g 0 1136746 1137180 ON 7 G13244 complement(1136746..1137180) similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase ubiquinol--cytochrome-c reductase assembly factor SAKL0G13266g 0 1137577 1139067 ON 7 G13266 complement(1137577..1139067) highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase catalyzes the epoxidation of squalene to 2 3-oxidosqualene plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine SAKL0G13288g 0 1139419 1141041 ON 7 G13288 complement(1139419..1141041) similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase may play a role in steroid detoxification forms volatile esters during fermentation which is important in brewing SAKL0G13310g 0 1141970 1143493 ON 7 G13310 complement(1141970..1143493) similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn6p and TATA-binding protein SAKL0G13332g 0 1143714 1145870 ON 7 G13332 complement(1143714..1145870) similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)-binding protein Pab1p likely involved in control of the extent of mRNA polyadenylation SAKL0G13354g 0 1146134 1147456 ON 7 G13354 complement(1146134..1147456) weakly similar to uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex SAKL0G13376g 0 1147643 1149508 ON 7 G13376 complement(1147643..1149508) weakly similar to uniprot|Q06451 Saccharomyces cerevisiae YPR156C TPO3 Polyamine transport protein SAKL0G13398g 1 1150537 1151511 ON 7 G13398 (1150537..1151511) highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Protein required for thiamine biosynthesis and for mitochondrial genome stability Sklu_7.trna22P 1 1152529 1152632 ON 7 tP-UGG (1152529..1152564,1152597..1152632) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.25 SAKL0G13464g 0 1154501 1155715 ON 7 G13464 complement(1154501..1155715) highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W RNR2 Ribonucleotide-diphosphate reductase (RNR) small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Sklu_7.trna23L 0 1156276 1156398 ON 7 tL-CAA complement(1156276..1156319,1156361..1156398) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.10 SAKL0G13508g 1 1158617 1159486 ON 7 G13508 (1158617..1159486) no similarity SAKL0G13530g 0 1159601 1160707 ON 7 G13530 complement(1159601..1160707) highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W SAKL0G13552g 1 1160994 1161785 ON 7 G13552 (1160994..1161785) similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Golgi integral membrane protein binds to the transport GTPases Ypt1p and Ypt31p SAKL0G13574g 1 1162034 1163758 ON 7 G13574 (1162034..1163758) similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C SAKL0G13596g 0 1163824 1165295 ON 7 G13596 complement(1163824..1165192,1165270..1165295) similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W HYS2 DNA polymerase III (delta) 55 kDa subunit essential for cell viability involved in DNA replication and DNA repair SAKL0G13618g 0 1165467 1168652 ON 7 G13618 complement(1165467..1168652) similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes converts phosphatidylserine to phosphatidylethanolamine SAKL0G13640g 1 1169225 1169497 ON 7 G13640 (1169225..1169497) some similarities with uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A SAKL0G13662g 0 1169772 1170857 ON 7 G13662 complement(1169772..1170857) similar to uniprot|P47065 Saccharomyces cerevisiae YJL023C PET130 Protein required for respiratory growth Sklu_YGOB_Anc_5.171b 1 1172424 1173620 ON 7 Anc_5.171b (1172424..1173014,1173018..1173620) ANNOTATED BY YGOB - Sklu_YGOB_Anc_5.171 1 1172424 1173017 OFF 7 Anc_5.171 (1172424..1173017) ANNOTATED BY YGOB - SAKL0G13706g 0 1173734 1177030 ON 7 G13706 complement(1173734..1177030) weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p localized predominantly to cortical actin patches SAKL0G13728g 1 1177295 1178377 ON 7 G13728 (1177295..1178377) weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Hypothetical ORF SAKL0G13750g 0 1178477 1179130 ON 7 G13750 complement(1178477..1179130) similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain SAKL0G13772g 0 1179687 1181081 ON 7 G13772 complement(1179687..1181081) weakly similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W KRE11 Protein involved in biosynthesis of cell wall beta-glucans subunit of the TRAPP (transport protein particle) complex which is involved in the late steps of endoplasmic reticulum to Golgi transport SAKL0G13794g 0 1181356 1182585 ON 7 G13794 complement(1181356..1181805,1182010..1182585) similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit SAKL0G13816g 1 1183028 1184962 ON 7 G13816 (1183028..1184962) similar to uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion localizes to the spindle pole body half bridge interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p SAKL0G13838g 1 1187112 1188683 ON 7 G13838 (1187112..1188683) similar to uniprot|P47071 Saccharomyces cerevisiae YJL016W SAKL0G13860g 1 1189910 1191517 ON 7 G13860 (1189910..1191517) highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo SAKL0G13882g 0 1191656 1194604 ON 7 G13882 complement(1191656..1194604) similar to uniprot|P41695 Saccharomyces cerevisiae YGR188C BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage associates with centromere DNA via Skp1p SAKL0G13904g 0 1194969 1197101 ON 7 G13904 complement(1194969..1197101) highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative) SAKL0G13926g 0 1197347 1197817 ON 7 G13926 complement(1197347..1197817) similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17 physically interacts with C31 C11 and TFIIIB70 may be involved in the recruitment of pol III by the preinitiation complex Sklu_7.trna24K 1 1198025 1198097 ON 7 tK-CUU (1198025..1198097) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G13970g 0 1198648 1200084 ON 7 G13970 complement(1198648..1200084) highly similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Putative glycosidase of the cell wall may have a role in cell wall architecture Sklu_7.trna25W 0 1200566 1200669 ON 7 tW-CCA complement(1200566..1200601,1200634..1200669) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 65.49 SAKL0G14014g 1 1202476 1204293 ON 7 G14014 (1202476..1204293) highly similar to uniprot|P06775 Saccharomyces cerevisiae YGR191W HIP1 High-affinity histidine permease also involved in the transport of manganese ions SAKL0G14036g 1 1204759 1209105 ON 7 G14036 (1204759..1209105) conserved hypothetical protein SAKL0G14058g 1 1209734 1210642 ON 7 G14058 (1209734..1210642) highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 involved in the identification of the start codon phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP SAKL0G14080g 1 1211318 1212322 ON 7 G14080 (1211318..1212322) similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W Hypothetical ORF SAKL0G14102g 0 1214345 1215343 ON 7 G14102 complement(1214345..1215343) highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases SAKL0G14113g 1 1215889 1216434 ON 7 G14113 (1215889..1216434) no similarity SAKL0G14124g 1 1219443 1220963 ON 7 G14124 (1219443..1220963) highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase catalyzes the primary step of intracellular sulfate activation essential for assimilatory reduction of sulfate to sulfide involved in methionine metabolism SAKL0G14146g 0 1221331 1222578 ON 7 G14146 complement(1221331..1222578) similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core SAKL0G14168g 0 1222838 1224733 ON 7 G14168 complement(1222838..1224733) similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 third enzyme in the xylose pathway; Xylulokinase SAKL0G14190g 0 1224821 1225087 ON 7 G14190 complement(1224821..1225087) similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A SPC1 Subunit of the signal peptidase complex (SPC) which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER) homolog of the SPC12 subunit of mammalian signal peptidase complex SAKL0G14212g 0 1225272 1226228 ON 7 G14212 complement(1225272..1226228) some similarities with uniprot|P47086 Saccharomyces cerevisiae YJR011C Hypothetical ORF SAKL0G14234g 1 1226299 1227336 ON 7 G14234 (1226299..1227336) conserved hypothetical protein SAKL0G14256g 1 1230063 1232306 ON 7 G14256 (1230063..1232306) conserved hypothetical protein Sklu_YGOB_Anc_5.148 0 1232469 1232819 ON 7 Anc_5.148 complement(1232469..1232819) ANNOTATED BY YGOB - SAKL0G14278g 1 1232975 1234174 ON 7 G14278 (1232975..1234174) similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1 4 mannosyltransferase I involved in GPI anchor biosynthesis requires Pbn1p for function homolog of mammalian PIG-M SAKL0G14300g 1 1234289 1235110 ON 7 G14300 (1234289..1235110) highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 superkiller ExtraCellular Mutant Ribosomal RNA Processing homolog of RNAse PH SAKL0G14322g 0 1235131 1237995 ON 7 G14322 complement(1235131..1237995) some similarities with uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function required for survival upon exposure to K1 killer toxin SAKL0G14344g 1 1238204 1238779 ON 7 G14344 (1238204..1238779) highly similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W RBF22 Hypothetical ORF SAKL0G14366g 1 1238951 1241119 ON 7 G14366 (1238951..1241119) similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0G14388g 0 1241254 1242207 ON 7 G14388 complement(1241254..1242207) weakly similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF SAKL0G14410g 1 1243126 1245408 ON 7 G14410 (1243126..1245408) similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase SAKL0G14432g 0 1245508 1247877 ON 7 G14432 complement(1245508..1247877) similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Elongator protein part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex target of Kluyveromyces lactis zymocin SAKL0G14454g 0 1248275 1250041 ON 7 G14454 complement(1248275..1250041) highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids SAKL0G14476g 1 1250462 1251763 ON 7 G14476 (1250462..1251763) similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase SAKL0G14498g 1 1252522 1252965 ON 7 G14498 (1252522..1252965) similar to uniprot|P42937 YGR203W Saccharomyces cerevisiae Probable protein tyrosine phosphatase of the CDC25-like phosphatase family SAKL0G14520g 0 1253028 1253516 ON 7 G14520 complement(1253028..1253516) similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline SAKL0G14542g 1 1253864 1256701 ON 7 G14542 (1253864..1256701) highly similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase involved in single carbon metabolism and required for biosynthesis of purines thymidylate methionine and histidine SAKL0G14564g 0 1256845 1257795 ON 7 G14564 complement(1256845..1257795) similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase SAKL0G14586g 1 1257984 1258892 ON 7 G14586 (1257984..1258892) similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W Protein that binds ATP crystal structure resembles that of E.coli pantothenate kinase Sklu_YGOB_Anc_5.131 0 1258993 1259646 OFF 7 Anc_5.131 complement(1258993..1259646) ANNOTATED BY YGOB - Sklu_YGOB_Anc_5.131b 0 1258993 1259907 ON 7 Anc_5.131b complement(1258993..1259456,1259652..1259907) ANNOTATED BY YGOB - SAKL0G14630g 1 1260070 1260393 ON 7 G14630 (1260070..1260393) similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing SAKL0G14652g 0 1260448 1261233 ON 7 G14652 complement(1260448..1261233) highly similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C Hypothetical ORF SAKL0G14674g 0 1262039 1262569 ON 7 G14674 complement(1262039..1262569) highly similar to uniprot|P47096 Saccharomyces cerevisiae YJR025C BNA1 3-hydroxyanthranilic acid dioxygenase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway SAKL0G14696g 1 1262785 1263093 ON 7 G14696 (1262785..1263093) similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W Hypothetical ORF SAKL0G14718g 0 1263168 1263947 ON 7 G14718 complement(1263168..1263947) highly similar to uniprot|P42940 YGR207C Saccharomyces cerevisiae YGR2 Hypothetical ORF SAKL0G14740g 1 1264151 1265089 ON 7 G14740 (1264151..1265089) similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 phosphoserine phosphatase SAKL0G14762g 0 1265378 1267075 ON 7 G14762 complement(1265378..1267075) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane SAKL0G14784g 0 1268332 1268643 ON 7 G14784 complement(1268332..1268643) highly similar to uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin Sklu_7.trna26S 0 1269497 1269604 ON 7 tS-AGA complement(1269497..1269541,1269568..1269604) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0G14850g 1 1270484 1273090 ON 7 G14850 (1270484..1273090) similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment interacts with spindle pole body component Spc72p SAKL0G14872g 0 1273371 1274552 ON 7 G14872 complement(1273371..1274552) conserved hypothetical protein SAKL0G14894g 1 1275005 1276699 ON 7 G14894 (1275005..1276699) uniprot|Q6XAF0 Saccharomyces kluyveri PDC12 Pyruvate decarboxylase SAKL0G14916g 0 1277225 1278970 ON 7 G14916 complement(1277225..1278970) uniprot|Q875Q9 Saccharomyces kluyveri DIP5 SAKL0G14938g 1 1282084 1283880 ON 7 G14938 (1282084..1283880) similar to uniprot|P36035 Saccharomyces cerevisiae YKL217W JEN1 Lactate transporter required for uptake of lactate and pyruvate expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions and repressed in the presence of glucose fructose and mannose SAKL0G14960g 0 1284200 1285435 ON 7 G14960 complement(1284200..1285435) highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Hypothetical ORF SAKL0G14982g 1 1285944 1287434 ON 7 G14982 (1285944..1287434) highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p) SAKL0G15004g 1 1288241 1289611 ON 7 G15004 (1288241..1289611) similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl- myriocin SAKL0G15026g 0 1290554 1292623 ON 7 G15026 complement(1290554..1292623) similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF SAKL0G15048g 1 1293525 1294627 ON 7 G15048 (1293525..1293614,1293959..1294627) highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit SAKL0G15070g 1 1295197 1295523 ON 7 G15070 (1295197..1295523) similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit SAKL0G15092g 0 1295664 1297505 ON 7 G15092 complement(1295664..1297505) similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol SAKL0G15114g 1 1297660 1303800 ON 7 G15114 (1297660..1303800) similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones SAKL0G15136g 0 1303874 1305583 ON 7 G15136 complement(1303874..1305583) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane Sklu_7.trna27G 0 1306202 1306272 ON 7 tG-GCC complement(1306202..1306272) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0G15180g 1 1306761 1310015 ON 7 G15180 (1306761..1310015) highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus SAKL0G15202g 0 1310222 1311034 ON 7 G15202 complement(1310222..1311034) highly similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit SAKL0G15224g 0 1311409 1313826 ON 7 G15224 complement(1311409..1313826) similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family SAKL0G15246g 0 1315036 1315689 ON 7 G15246 complement(1315036..1315689) highly similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit SAKL0G15268g 1 1316122 1316673 ON 7 G15268 (1316122..1316673) highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA SAKL0G15290g 0 1316851 1319097 ON 7 G15290 complement(1316851..1319097) some similarities with uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate SAKL0G15334g 1 1320128 1320952 ON 7 G15334 (1320128..1320952) similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane SAKL0G15356g 0 1321036 1322301 ON 7 G15356 complement(1321036..1322301) similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5-bisphosphate-binding protein predicted to fold as a seven-bladed beta-propeller displays punctate cytoplasmic localization SAKL0G15378g 1 1323190 1325290 ON 7 G15378 (1323190..1324305,1324796..1325290) weakly similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation highly induced during sporulation activator of meiotic anaphase promoting complex Required for sporulation highly induced during sporulation SAKL0G15400g 1 1325560 1327194 ON 7 G15400 (1325560..1327194) similar to gnl|GLV|KLLA0E15928g Kluyveromyces lactis KLLA0E15928g and weakly similar to YHR150W uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p SAKL0G15422g 0 1327247 1328746 ON 7 G15422 complement(1327247..1328746) similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF SAKL0G15444g 1 1329020 1330534 ON 7 G15444 (1329020..1330534) similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1 SAKL0G15466g 0 1330664 1332211 ON 7 G15466 complement(1330664..1332211) similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein SAKL0G15488g 1 1333677 1333946 ON 7 G15488 (1333677..1333946) some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W SAKL0G15510g 0 1334598 1335524 ON 7 G15510 complement(1334598..1335524) highly similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p SAKL0G15532g 1 1336097 1336798 ON 7 G15532 (1336097..1336798) similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 SAKL0G15554g 0 1337081 1340353 ON 7 G15554 complement(1337081..1340353) similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p SAKL0G15576g 0 1340513 1341136 ON 7 G15576 complement(1340513..1340804,1340874..1341136) weakly similar to uniprot|P17122 Saccharomyces cerevisiae YHR153C SPO16 Protein of unknown function, required for spore formation Sklu_7.trna28A 0 1341258 1341330 ON 7 tA-AGC complement(1341258..1341330) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 SAKL0G15620g 1 1342049 1344688 ON 7 G15620 (1342049..1344688) some similarities with uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing SAKL0G15642g 1 1345342 1346535 ON 7 G15642 (1345342..1346535) highly similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response SAKL0G15664g 0 1346731 1347423 ON 7 G15664 complement(1346731..1347423) similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF SAKL0G15686g 0 1349161 1351017 ON 7 G15686 complement(1349161..1351017) some similarities with uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p SAKL0G15708g 1 1351648 1352181 ON 7 G15708 (1351648..1352181) similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein SAKL0G15730g 0 1352364 1354322 ON 7 G15730 complement(1352364..1354322) similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region SAKL0G15752g 1 1355625 1357604 ON 7 G15752 (1355625..1357604) some similarities with uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress- responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies SAKL0G15774g 1 1358187 1358987 ON 7 G15774 (1358187..1358987) weakly similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W Hypothetical ORF SAKL0G15796g 0 1359232 1362462 ON 7 G15796 complement(1359232..1362462) weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Hypothetical ORF SAKL0G15818g 1 1363027 1364970 ON 7 G15818 (1363027..1364970) similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain SAKL0G15840g 1 1365685 1366734 ON 7 G15840 (1365685..1366734) similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p SAKL0G15884g 0 1367753 1368512 ON 7 G15884 complement(1367753..1368040,1368456..1368512) highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit SAKL0G15906g 1 1369149 1370024 ON 7 G15906 (1369149..1370024) similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Hypothetical ORF SAKL0G15928g 1 1370256 1370948 ON 7 G15928 (1370256..1370948) similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0G15950g 0 1371029 1371352 ON 7 G15950 complement(1371029..1371352) similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C Hypothetical ORF SAKL0G15972g 1 1371625 1374699 ON 7 G15972 (1371625..1374699) similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis SAKL0G15994g 0 1374780 1377614 ON 7 G15994 complement(1374780..1377614) highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data SAKL0G16016g 1 1378206 1381568 ON 7 G16016 (1378206..1381568) similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase SAKL0G16038g 1 1381772 1382608 ON 7 G16038 (1381772..1382608) similar to uniprot|Q06686 Saccharomyces cerevisiae YLR411W CTR3 High-affinity copper transporter of the plasma membrane acts as a trimer gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae SAKL0G16060g 0 1383092 1384366 ON 7 G16060 complement(1383092..1384366) highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes SAKL0G16082g 1 1384927 1385727 ON 7 G16082 (1384927..1385727) similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W Hypothetical ORF SAKL0G16104g 0 1386151 1392297 ON 7 G16104 complement(1386151..1392297) highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities SAKL0G16126g 0 1394366 1395052 ON 7 G16126 complement(1394366..1395052) highly similar to uniprot|Q6HD38 Bacillus thuringiensis subsp BT9727_4222 ThiJ/PfpI family protein SAKL0G16148g 0 1395891 1396808 ON 7 G16148 complement(1395891..1396808) similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature SAKL0G16170g 0 1397023 1398378 ON 7 G16170 complement(1397023..1398378) similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase SAKL0G16192g 0 1399297 1400868 ON 7 G16192 complement(1399297..1400868) similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate SAKL0G16214g 1 1401850 1402368 ON 7 G16214 (1401850..1402368) similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA SAKL0G16236g 1 1403769 1405796 ON 7 G16236 (1403769..1405796) weakly similar to uniprot|P34231 Saccharomyces cerevisiae YKL187C and weakly similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W SAKL0G16258g 0 1406494 1407282 ON 7 G16258 complement(1406494..1407282) similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud SAKL0G16280g 1 1408229 1410607 ON 7 G16280 (1408229..1410607) similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP- binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2 SAKL0G16302g 1 1410886 1412442 ON 7 G16302 (1410886..1412442) similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome SAKL0G16324g 0 1412461 1413552 ON 7 G16324 complement(1412461..1413552) similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response Sklu_7.trna29L 1 1415739 1415822 ON 7 tL-UAA (1415739..1415822) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 69.31 SAKL0G16390g 0 1415964 1420208 ON 7 G16390 complement(1415964..1420208) similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF SAKL0G16412g 1 1420439 1421530 ON 7 G16412 (1420439..1421530) similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones SAKL0G16434g 1 1423039 1423932 ON 7 G16434 (1423039..1423932) some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator SAKL0G16456g 1 1424881 1426569 ON 7 G16456 (1424881..1426569) highly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression SAKL0G16478g 0 1426974 1427560 ON 7 G16478 complement(1426974..1427449,1427509..1427560) highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase; regulatory B subunit of calcineurin SAKL0G16500g 0 1427774 1429606 ON 7 G16500 complement(1427774..1429606) similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p SAKL0G16522g 1 1429749 1430855 ON 7 G16522 (1429749..1430855) highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase SAKL0G16544g 0 1430914 1431231 ON 7 G16544 complement(1430914..1431231) conserved hypothetical protein SAKL0G16566g 0 1431353 1431844 ON 7 G16566 complement(1431353..1431844) similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid SAKL0G16588g 1 1432497 1433066 ON 7 G16588 (1432497..1433066) conserved hypothetical protein SAKL0G16610g 1 1434140 1440040 ON 7 G16610 (1434140..1440040) similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF SAKL0G16632g 1 1440221 1440592 ON 7 G16632 (1440221..1440592) similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p SAKL0G16654g 1 1441107 1442168 ON 7 G16654 (1441107..1442168) similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase SAKL0G16676g 1 1442322 1443650 ON 7 G16676 (1442322..1443650) similar to uniprot|P53960 Saccharomyces cerevisiae YNL040W Hypothetical ORF SAKL0G16698g 1 1443707 1445194 ON 7 G16698 (1443707..1445194) similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase SAKL0G16720g 0 1445248 1446489 ON 7 G16720 complement(1445248..1446489) similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway SAKL0G16742g 1 1446647 1448695 ON 7 G16742 (1446647..1448695) similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA SAKL0G16764g 0 1448847 1449620 ON 7 G16764 complement(1448847..1449620) some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins SAKL0G16786g 1 1450325 1450927 ON 7 G16786 (1450325..1450927) highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport Sklu_7.trna30N 0 1451686 1451759 ON 7 tN-GUU complement(1451686..1451759) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 76.93 SAKL0G16852g 1 1452894 1454636 ON 7 G16852 (1452894..1454636) similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions SAKL0G16874g 1 1454954 1459186 ON 7 G16874 (1454954..1459186) similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate SAKL0G16896g 1 1459383 1460417 ON 7 G16896 (1459383..1459462,1459520..1460417) similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF SAKL0G16918g 0 1460454 1460963 ON 7 G16918 complement(1460454..1460963) similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25 SAKL0G16940g 1 1461347 1463230 ON 7 G16940 (1461347..1463230) similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA SAKL0G16962g 1 1463359 1465290 ON 7 G16962 (1463359..1463363,1463442..1465290) similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity SAKL0G16984g 1 1465681 1472556 ON 7 G16984 (1465681..1472556) similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate SAKL0G17006g 0 1472653 1473948 ON 7 G17006 complement(1472653..1473948) similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway SAKL0G17028g 1 1474305 1475696 ON 7 G17028 (1474305..1475696) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin SAKL0G17050g 1 1477016 1478899 ON 7 G17050 (1477016..1477469,1477785..1478899) highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 and to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 and to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation SAKL0G17094g 0 1479120 1480790 ON 7 G17094 complement(1479120..1480790) similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein SAKL0G17116g 1 1481042 1481665 ON 7 G17116 (1481042..1481665) similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing SAKL0G17138g 0 1481741 1485475 ON 7 G17138 complement(1481741..1485475) weakly similar to uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function SAKL0G17160g 0 1486411 1486839 ON 7 G17160 complement(1486411..1486839) some similarities with Saccharomyces cerevisiae Hypothetical ORF and with YML058W uniprot|Q04964 Saccharomyces cerevisiae SML1 Ribonucleotide reductase inhibitor SAKL0G17182g 1 1487718 1489022 ON 7 G17182 (1487718..1489022) highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive SAKL0G17204g 0 1489336 1490334 ON 7 G17204 complement(1489336..1490334) highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases SAKL0G17226g 0 1490837 1492204 ON 7 G17226 complement(1490837..1492204) no similarity SAKL0G17248g 1 1492432 1497204 ON 7 G17248 (1492432..1497204) similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine SAKL0G17270g 0 1497331 1497582 ON 7 G17270 complement(1497331..1497582) highly similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay SAKL0G17292g 1 1497928 1498875 ON 7 G17292 (1497928..1498875) similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit SAKL0G17314g 0 1498965 1500134 ON 7 G17314 complement(1498965..1500134) similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA SAKL0G17336g 1 1500402 1503239 ON 7 G17336 (1500402..1503239) similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA SAKL0G17358g 0 1503342 1505471 ON 7 G17358 complement(1503342..1505471) similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion SAKL0G17380g 1 1505539 1506684 ON 7 G17380 (1505539..1506684) some similarities with uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex which is a nuclear complex comprised of Hpr1p Mft1p Rlr1p and Thp2p that is involved in transcription elongation and mitotic recombination SAKL0G17402g 0 1506856 1507626 ON 7 G17402 complement(1506856..1507626) highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit SAKL0G17424g 1 1508263 1508913 ON 7 G17424 (1508263..1508913) similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily SAKL0G17446g 0 1509131 1512181 ON 7 G17446 complement(1509131..1512181) similar to uniprot|P54784 Saccharomyces cerevisiae YML065W ORC1 Largest subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p SAKL0G17468g 1 1513069 1514334 ON 7 G17468 (1513069..1514334) similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential protein of unknown function SAKL0G17490g 1 1514467 1515795 ON 7 G17490 (1514467..1515795) weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly SAKL0G17512g 1 1516023 1517137 ON 7 G17512 (1516023..1516053,1516146..1517137) similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles SAKL0G17534g 1 1517220 1517808 ON 7 G17534 (1517220..1517561,1517629..1517808) weakly similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF SAKL0G17556g 0 1519836 1521560 ON 7 G17556 complement(1519836..1521560) highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation SAKL0G17578g 0 1521677 1523431 ON 7 G17578 complement(1521677..1523431) highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation SAKL0G17600g 0 1523623 1524948 ON 7 G17600 complement(1523623..1524948) conserved hypothetical protein SAKL0G17622g 0 1525163 1527193 ON 7 G17622 complement(1525163..1527193) conserved hypothetical protein Sklu_7.trna31R 1 1527384 1527455 ON 7 tR-UCU (1527384..1527455) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0G17666g 1 1527471 1528082 ON 7 G17666 (1527471..1528082) conserved hypothetical protein SAKL0G17688g 0 1528077 1528847 ON 7 G17688 complement(1528077..1528847) no similarity SAKL0G17710g 1 1529069 1530328 ON 7 G17710 (1529069..1530328) similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Hypothetical ORF SAKL0G17732g 0 1532502 1533062 ON 7 G17732 complement(1532502..1533062) conserved hypothetical protein SAKL0G17754g 1 1533463 1536756 ON 7 G17754 (1533463..1536756) conserved hypothetical protein SAKL0G17776g 0 1537055 1538098 ON 7 G17776 complement(1537055..1538098) highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d SAKL0G17798g 1 1538365 1539615 ON 7 G17798 (1538365..1539615) similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex SAKL0G17820g 1 1539639 1544306 ON 7 G17820 (1539639..1544306) similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact SAKL0G17842g 1 1544972 1545921 ON 7 G17842 (1544972..1544986,1545403..1545921) highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W SAKL0G17864g 1 1546478 1547692 ON 7 G17864 (1546478..1547692) highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae SAKL0G17886g 1 1548370 1551510 ON 7 G17886 (1548370..1551510) similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae SAKL0G17908g 1 1552344 1554773 ON 7 G17908 (1552344..1554773) similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor SAKL0G17930g 0 1554848 1555389 ON 7 G17930 complement(1554848..1555290,1555353..1555389) similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi SAKL0G17952g 0 1555520 1556767 ON 7 G17952 complement(1555520..1556767) similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p SAKL0G17974g 0 1557187 1557744 ON 7 G17974 complement(1557187..1557744) highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria SAKL0G17996g 0 1557875 1560202 ON 7 G17996 complement(1557875..1560202) similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 SAKL0G18018g 0 1560570 1561265 ON 7 G18018 complement(1560570..1561265) similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin) SAKL0G18040g 0 1561358 1562674 ON 7 G18040 complement(1561358..1562674) similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17 SAKL0G18062g 0 1562943 1566659 ON 7 G18062 complement(1562943..1566659) similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W Hypothetical ORF Sklu_YGOB_AER160C 0 1567504 1567719 ON 7 AER160C complement(1567504..1567719) ANNOTATED BY YGOB - SAKL0G18084g 0 1567873 1568871 OFF 7 G18084 complement(1567873..1568871) no similarity SAKL0G18106g 0 1569137 1570144 ON 7 G18106 complement(1569137..1570144) similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0G18128g 0 1570639 1571670 ON 7 G18128 complement(1570639..1571670) similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase SAKL0G18150g 1 1572224 1572400 ON 7 G18150 (1572224..1572400) similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase SAKL0G18172g 0 1572652 1574673 ON 7 G18172 complement(1572652..1574673) similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine SAKL0G18194g 1 1574930 1576708 ON 7 G18194 (1574930..1576708) similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane SAKL0G18216g 0 1576755 1577153 ON 7 G18216 complement(1576755..1577153) similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion SAKL0G18238g 1 1577281 1578081 ON 7 G18238 (1577281..1578081) similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Hypothetical ORF SAKL0G18260g 0 1578118 1578654 ON 7 G18260 complement(1578118..1578654) similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes Sklu_7.trna32F 0 1578805 1578897 ON 7 tF-GAA complement(1578805..1578840,1578861..1578897) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.92 SAKL0G18304g 1 1579211 1581007 ON 7 G18304 (1579211..1581007) highly similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology SAKL0G18326g 1 1581170 1582069 ON 7 G18326 (1581170..1582069) weakly similar to uniprot|P38881 Saccharomyces cerevisiae YHR195W NVJ1 Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) SAKL0G18348g 1 1582267 1585422 ON 7 G18348 (1582267..1585422) similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog SAKL0G18370g 1 1585734 1587371 ON 7 G18370 (1585734..1587371) similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0G18392g 1 1588074 1588715 ON 7 G18392 (1588074..1588715) highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase SAKL0G18414g 0 1588834 1590873 ON 7 G18414 complement(1588834..1590873) similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild- type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus Sklu_7.trna33K 0 1591014 1591086 ON 7 tK-CUU complement(1591014..1591086) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0G18458g 1 1591284 1593578 ON 7 G18458 (1591284..1593578) similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein SAKL0G18480g 0 1593594 1594280 ON 7 G18480 complement(1593594..1594280) similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance component of the kinetochore binds to centromeric DNA in a Ctf19p-dependent manner SAKL0G18502g 1 1595090 1595353 ON 7 G18502 (1595090..1595353) similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome SAKL0G18524g 0 1595439 1596716 ON 7 G18524 complement(1595439..1596716) similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C Hypothetical ORF SAKL0G18546g 1 1597441 1599648 ON 7 G18546 (1597441..1599648) conserved hypothetical protein SAKL0G18568g 0 1599697 1600632 ON 7 G18568 complement(1599697..1600632) similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non-tagged protein was localized to the mitochondria SAKL0G18590g 0 1600926 1605203 ON 7 G18590 complement(1600926..1605203) highly similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C ECM17 Sulfite reductase beta subunit involved in amino acid biosynthesis transcription repressed by methionine SAKL0G18612g 0 1605572 1605891 ON 7 G18612 complement(1605572..1605759,1605825..1605891) weakly similar to uniprot|P38885 Saccharomyces cerevisiae YHR199C hypothetical protein SAKL0G18634g 1 1606082 1606867 ON 7 G18634 (1606082..1606867) highly similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome SAKL0G18656g 1 1607685 1612415 ON 7 G18656 (1607685..1612415) similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1 SAKL0G18678g 0 1612509 1613658 ON 7 G18678 complement(1612509..1613554,1613625..1613658) similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase SAKL0G18700g 0 1613786 1618714 ON 7 G18700 complement(1613786..1618714) similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor SAKL0G18722g 1 1618758 1619891 ON 7 G18722 (1618758..1619891) similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Protein required for cell viability SAKL0G18744g 0 1619910 1621055 ON 7 G18744 complement(1619910..1621055) similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix SAKL0G18766g 1 1621177 1622211 ON 7 G18766 (1621177..1622211) similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Hypothetical ORF SAKL0G18788g 0 1622778 1624103 ON 7 G18788 complement(1622778..1624103) highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ECM40 Mitochondrial ornithine acetyltransferase catalyzes the fifth step in arginine biosynthesis also possesses acetylglutamate synthase activity regenerates acetylglutamate while forming ornithine SAKL0G18810g 0 1624866 1626581 ON 7 G18810 complement(1624866..1626581) highly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock SAKL0G18832g 0 1627709 1629847 ON 7 G18832 complement(1627709..1629847) similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box RNA helicase required for 18S rRNA synthesis SAKL0G18854g 1 1630121 1630846 ON 7 G18854 (1630121..1630846) weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W SAKL0G18876g 1 1631020 1632840 ON 7 G18876 (1631020..1632840) weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase SAKL0G18898g 1 1633040 1634617 ON 7 G18898 (1633040..1634617) similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen may form a complex with Jem1p and Kar2p expression of the gene is regulated by pheromone SAKL0G18920g 0 1634668 1636617 ON 7 G18920 complement(1634668..1636617) weakly similar to uniprot|P32364 Saccharomyces cerevisiae YKL079W SMY1 not believed to act as a kinesin, colocalizes with Myo2p; kinesin heavy chain homolog SAKL0G18942g 0 1636930 1638108 ON 7 G18942 complement(1636930..1638108) highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector SAKL0G18964g 0 1638827 1640268 ON 7 G18964 complement(1638827..1639854,1640064..1640268) similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF-1gamma SAKL0G19008g 1 1640890 1642233 ON 7 G19008 (1640890..1642233) similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability SAKL0G19030g 1 1642608 1645343 ON 7 G19030 (1642608..1645343) similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration SAKL0G19052g 0 1645403 1646689 ON 7 G19052 complement(1645403..1646689) similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p SAKL0G19074g 1 1646858 1648156 ON 7 G19074 (1646858..1648156) conserved hypothetical protein SAKL0G19096g 1 1648861 1650306 ON 7 G19096 (1648861..1650306) some similarities with uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth SAKL0G19118g 0 1650328 1650675 ON 7 G19118 complement(1650328..1650675) similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex SAKL0G19140g 0 1651367 1652374 ON 7 G19140 complement(1651367..1652374) highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle SAKL0G19162g 0 1652941 1653351 ON 7 G19162 complement(1652941..1653351) similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes SAKL0G19184g 0 1653748 1655106 ON 7 G19184 complement(1653748..1655106) highly similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response activates the pathway via Scp160p SAKL0G19206g 1 1655715 1656485 ON 7 G19206 (1655715..1656485) similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1 SAKL0G19228g 0 1656757 1657032 ON 7 G19228 complement(1656757..1657032) highly similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process SAKL0G19250g 0 1657538 1659034 ON 7 G19250 complement(1657538..1659034) some similarities with uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability SAKL0G19272g 0 1659979 1660881 ON 7 G19272 complement(1659979..1660881) conserved hypothetical protein SAKL0G19294g 1 1661601 1662734 ON 7 G19294 (1661601..1662734) similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease SAKL0G19316g 0 1662838 1663509 ON 7 G19316 complement(1662838..1663509) highly similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Hypothetical ORF SAKL0G19338g 1 1663777 1664283 ON 7 G19338 (1663777..1664283) highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum SAKL0G19360g 0 1664386 1666092 ON 7 G19360 complement(1664386..1666092) similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex SAKL0G19382g 1 1666296 1666811 ON 7 G19382 (1666296..1666811) highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches SAKL0G19404g 1 1667193 1670582 ON 7 G19404 (1667193..1670582) similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism SAKL0G19426g 0 1670664 1671386 ON 7 G19426 complement(1670664..1671386) similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control SAKL0G19448g 1 1672352 1677490 ON 7 G19448 (1672352..1677490) similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit SAKL0G19470g 0 1677759 1680254 ON 7 G19470 complement(1677759..1680254) similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type SAKL0G19492g 1 1680951 1681475 ON 7 G19492 (1680951..1681475) highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0G19514g 1 1681646 1683628 ON 7 G19514 (1681646..1683628) similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities SAKL0G19536g 0 1683650 1684636 ON 7 G19536 complement(1683650..1684636) highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres SAKL0G19558g 1 1685516 1685895 ON 7 G19558 (1685516..1685524,1685584..1685895) similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A Hypothetical ORF identified by homology SAKL0G19580g 1 1687140 1688165 ON 7 G19580 (1687140..1688165) weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC) needed for meiotic nuclear division SAKL0G19602g 0 1688208 1689446 ON 7 G19602 complement(1688208..1689446) similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase SAKL0G19624g 0 1689467 1690393 ON 7 G19624 complement(1689467..1690393) similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit SAKL0G19646g 1 1690766 1694122 ON 7 G19646 (1690766..1694122) similar to uniprot|P40578 MGA2 and to YKL020C uniprot|P35210 SPT23, Saccharomyces cerevisiae ER membrane proteins involved in regulation of OLE1 transcription SAKL0G19668g 1 1695030 1696214 ON 7 G19668 (1695030..1696214) similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta-transducin repeats SAKL0G19690g 0 1696323 1697447 ON 7 G19690 complement(1696323..1697447) highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L- lysine-forming) catalyzes the conversion of saccharopine to L-lysine which is the final step in the lysine biosynthesis pathway SAKL0G19712g 1 1697758 1699923 ON 7 G19712 (1697758..1699923) similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation SAKL0G19734g 0 1700288 1701607 ON 7 G19734 complement(1700288..1701607) no similarity SAKL0G19756g 0 1702194 1703063 ON 7 G19756 complement(1702194..1703063) highly similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6 SAKL0G19778g 0 1703584 1704417 ON 7 G19778 complement(1703584..1703928,1703983..1704417) similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C Hypothetical ORF SAKL0G19800g 1 1704549 1706417 ON 7 G19800 (1704549..1706417) similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes SAKL0G19822g 1 1706686 1707417 ON 7 G19822 (1706686..1707417) no similarity SAKL0G19844g 1 1708176 1709894 ON 7 G19844 (1708176..1709894) highly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily expression is induced by low levels of glucose and repressed by high levels of glucose SAKL0G19866g 0 1713901 1715361 ON 7 G19866 complement(1713901..1715361) weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability SAKL0G19888g 0 1718964 1720112 ON 7 G19888 complement(1718964..1720112) conserved hypothetical protein SAKL0G19910g 1 1725001 1729239 ON 7 G19910 (1725001..1729239) some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C SAKL0H00132g 0 6682 8373 ON 8 H00132 complement(6682..8373) similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane SAKL0H00176g 1 15517 18768 ON 8 H00176 (15517..18768) conserved hypothetical protein SAKL0H00286g 0 28264 32364 ON 8 H00286 complement(28264..32364) conserved hypothetical protein SAKL0H00330g 0 40564 42300 ON 8 H00330 complement(40564..42300) weakly similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. SAKL0H00374g 1 45725 47011 ON 8 H00374 (45725..47011) weakly similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 Alcohol dehydrogenase isoenzyme III, shows a high affinity for alcohols with a double bond conjugated to the alcohol group SAKL0H00396g 0 47944 50376 ON 8 H00396 complement(47944..50376) similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases SAKL0H00418g 1 50575 54147 ON 8 H00418 (50575..54147) similar to uniprot|P50101 Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease that may play a role in ubiquitin precursor processing SAKL0H00440g 0 54174 55064 ON 8 H00440 complement(54174..55064) similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT SAKL0H00462g 1 55233 57062 ON 8 H00462 (55233..57062) similar to gnl|GLV|KLLA0C14025g Kluyveromyces lactis KLLA0C14025g and similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data SAKL0H00484g 0 57353 58513 ON 8 H00484 complement(57353..58513) some similarities with uniprot|P53334 Saccharomyces cerevisiae YGR279C SAKL0H00506g 1 59093 64459 ON 8 H00506 (59093..64459) highly similar to uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3 Protein of unknown function has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p SAKL0H00528g 1 64586 66457 ON 8 H00528 (64586..66457) similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor SAKL0H00550g 1 67033 68688 ON 8 H00550 (67033..68688) similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor SAKL0H00572g 0 68848 69687 ON 8 H00572 complement(68848..69687) some similarities with uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability SAKL0H00594g 0 70161 73457 ON 8 H00594 complement(70161..73457) highly similar to uniprot|Q751N9 Ashbya gossypii AGL349C AGL349Cp and similar to YMR308C uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p SAKL0H00616g 1 73754 75934 ON 8 H00616 (73754..75934) some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression SAKL0H00638g 0 76073 78019 ON 8 H00638 complement(76073..78019) conserved hypothetical protein SAKL0H00660g 0 78740 81478 ON 8 H00660 complement(78740..81478) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0H00682g 0 81989 84757 ON 8 H00682 complement(81989..84757) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0H00704g 1 85322 89641 ON 8 H00704 (85322..89641) similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane transporter of the ATP- binding cassette (ABC) family mediates export of many different organic anions including oligomycin SAKL0H00726g 1 90260 92509 ON 8 H00726 (90260..92509) conserved hypothetical protein SAKL0H00748g 0 93042 95507 ON 8 H00748 complement(93042..95507) similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3) involved in the assembly of preinitiation complex and start codon selection SAKL0H00770g 0 95976 96914 ON 8 H00770 complement(95976..96914) highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1 3-glucanase major protein of the cell wall involved in cell wall maintenance SAKL0H00792g 0 97159 98448 ON 8 H00792 complement(97159..98448) similar to uniprot|Q04867 Saccharomyces cerevisiae YMR310C Hypothetical ORF SAKL0H00814g 0 98689 99300 ON 8 H00814 complement(98689..99300) similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p) involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2 SAKL0H00836g 0 100010 100927 ON 8 H00836 complement(100010..100927) highly similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo SAKL0H00858g 0 101231 102529 ON 8 H00858 complement(101231..102529) highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Cytosolic ribosome-associated chaperone contains a DnaJ domain together with Ssz1p acts as a chaperone for nascent polypeptide chains SAKL0H00880g 1 102764 103588 ON 8 H00880 (102764..103588) similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity SAKL0H00902g 0 103678 105420 ON 8 H00902 complement(103678..105420) highly similar to uniprot|Q751N4 Ashbya gossypii AGL337C AGL337Cp and similar to uniprot|P40308 YMR313C Saccharomyces cerevisiae TGL3 Triacylglycerol lipase of the lipid particle SAKL0H00946g 1 106740 107441 ON 8 H00946 (106740..107441) highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 20S proteasome alpha-type subunit SAKL0H00968g 1 107767 109869 ON 8 H00968 (107767..109869) highly similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol member of the ATP-binding cassette (ABC) transporter family SAKL0H00990g 1 110417 111949 ON 8 H00990 (110417..111949) uniprot|Q12698 Saccharomyces kluyveri ADE4 Amidophosphoribosyltransferase SAKL0H01012g 1 112517 113629 ON 8 H01012 (112517..113629) similar to uniprot|Q751N0 Ashbya gossypii AGL333W AGL333Wp and weakly similar to YMR299C uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC) localizes with dynein null mutant is defective in nuclear migration SAKL0H01034g 1 113946 115946 ON 8 H01034 (113946..115946) similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3'exoribonuclease required for 5S and tRNA- Arg3 maturation SAKL0H01056g 0 116010 116519 ON 8 H01056 complement(116010..116519) similar to uniprot|Q751M8 Ashbya gossypii AGL331C AGL331Cp and weakly similar to YGR275W uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Regulator of Ty1 Transposition regulator of Ty1 transposition SAKL0H01078g 1 116763 119813 ON 8 H01078 (116763..119813) similar to uniprot|P46677 YGR274C Saccharomyces cerevisiae TAF1 TFIID subunit (145 kDa) involved in RNA polymerase II transcription initiation SAKL0H01100g 0 119902 120318 ON 8 H01100 complement(119902..120318) similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W Protein required for cell viability SAKL0H01122g 0 120648 122234 ON 8 H01122 complement(120648..122234) highly similar to gnl|GLV|KLLA0A09977g Kluyveromyces lactis KLLA0A09977g and similar to YMR297W uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C) involved in protein degradation in the vacuole and required for full protein degradation during sporulation SAKL0H01144g 1 123179 124831 ON 8 H01144 (123179..124831) similar to uniprot|P25045 YMR296C Saccharomyces cerevisiae LCB1 Component of serine palmitoyltransferase responsible along with Lcb2p for the first committed step in sphingolipid synthesis SAKL0H01166g 1 125324 125902 ON 8 H01166 (125324..125902) similar to uniprot|Q03559 YMR295C Saccharomyces cerevisiae Protein of unknown function SAKL0H01188g 1 126464 127162 ON 8 H01188 (126464..127162) similar to uniprot|P53328 YGR272C Saccharomyces cerevisiae Hypothetical ORF SAKL0H01210g 0 127235 133099 ON 8 H01210 complement(127235..133099) highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 SKI2-like helicase SAKL0H01232g 0 133275 134372 ON 8 H01232 complement(133275..134372) similar to uniprot|Q75D83 Ashbya gossypii ABR141W ABR141Wp and some similarites with YMR294W uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex consisting of Nip100p Jnm1p and Arp1p required for proper nuclear migration and spindle partitioning during mitotic anaphase B SAKL0H01254g 1 134504 135895 ON 8 H01254 (134504..135895) similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C Uncharacterized ORF SAKL0H01276g 0 136032 140045 ON 8 H01276 complement(136032..140045) similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein of unknown function member of CDC48/PAS1/SEC18 family of ATPases potentially phosphorylated by Cdc28p SAKL0H01298g 0 140419 140894 ON 8 H01298 complement(140419..140813,140870..140894) similar to uniprot|Q03554 YMR292w Saccharomyces GOT1 evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes SAKL0H01320g 1 141328 141885 ON 8 H01320 (141328..141885) some similarities with uniprot|P40325 YGR268C Saccharomyces cerevisiae HUA1 uncharacterized ORF SAKL0H01342g 1 142399 143130 ON 8 H01342 (142399..143130) highly similar to uniprot|P51601 YGR267C Saccharomyces cerevisiae FOL2 GTP-cyclohydrolase I SAKL0H01364g 0 143450 145141 ON 8 H01364 complement(143450..145141) similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W Hypothetical ORF SAKL0H01386g 0 145506 147584 ON 8 H01386 complement(145506..147584) similar to uniprot|P53326 YGR266W Saccharomyces cerevisiae probably contains a single transmembrane span SAKL0H01408g 1 148807 149124 ON 8 H01408 (148807..149124) no similarity SAKL0H01430g 1 149724 151226 ON 8 H01430 (149724..151226) highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase localizes to both the nuclear periphery and nucleolus highly enriched in nuclear pore complex fractions SAKL0H01452g 1 153061 155316 ON 8 H01452 (153061..155316) highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p which increases the catalytic efficiency of both tRNA synthetases also has a role in nuclear export of tRNAs SAKL0H01474g 1 155887 156678 ON 8 H01474 (155887..156678) highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern SAKL0H01496g 0 156706 157878 ON 8 H01496 complement(156706..157878) similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 4-amino-4-deoxychorismate lyase catalyzes the third step in para-aminobenzoic acid biosynthesis Sklu_8.trna1K 1 158057 158129 ON 8 tK-CUU (158057..158129) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0H01540g 1 158619 161111 ON 8 H01540 (158619..161111) similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function putative beta adaptin component of the membrane-associate clathrin assembly complex SAKL0H01562g 0 161166 164120 ON 8 H01562 complement(161166..164120) highly similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 SAKL0H01584g 1 164406 166427 ON 8 H01584 (164406..166427) similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins human PIG-Tp homolog SAKL0H01606g 0 167455 168357 ON 8 H01606 complement(167455..168357) similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of the Elp4p-Iki1p-Elp6p-subcomplex of RNA polymerase II elongator complex which is a histone acetyltransferase iki1 mutations confer resistance to the K. lactis toxin zymocin SAKL0H01628g 1 168606 173270 ON 8 H01628 (168606..173270) similar to gnl|GLV|CAGL0M13409g Candida glabrata CAGL0M13409g and some similarites with YHR186C uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1 a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p Lst8p and Tco89p contains four HEAT repeats and seven WD-40 repeats may act as a scaffold protein to couple TOR and its effectors SAKL0H01650g 0 173357 174898 ON 8 H01650 complement(173357..174898) similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease Sklu_8.trna2V 1 177642 177714 ON 8 tV-CAC (177642..177714) tRNA Type: Val (V) | Anti-Codon: CAC | Cove Score: 75.70 SAKL0H01760g 1 178096 181197 ON 8 H01760 (178096..181197) similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein SAKL0H01782g 1 181458 182255 ON 8 H01782 (181458..182255) some similarities with uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein required for prospore membrane formation at selected spindle poles ensures functionality of all four spindle pole bodies of a cell during meiosis II not required for meiotic recombination or meiotic chromosome segregation SAKL0H01804g 1 182495 183583 ON 8 H01804 (182495..183583) similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor SAKL0H01826g 0 183741 185594 ON 8 H01826 complement(183741..185594) weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and spore formation SAKL0H01848g 0 186266 187699 ON 8 H01848 complement(186266..187699) highly similar to uniprot|P53319 Saccharomyces cerevisiae YGR256W GND2 and to uniprot|P38720 Saccharomyces cerevisiae YHR183W GND1 6-phosphogluconate dehydrogenase(decarboxylating) SAKL0H01870g 0 188511 190973 ON 8 H01870 complement(188511..190973) weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm SAKL0H01892g 0 191200 191886 ON 8 H01892 complement(191200..191886) similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Component of Sed5p vesicles Sklu_8.trna3T 0 192341 192412 ON 8 tT-UGU complement(192341..192412) tRNA Type: Thr (T) | Anti-Codon: UGU | Cove Score: 79.33 SAKL0H01958g 0 193079 195055 ON 8 H01958 complement(193079..195055) similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 binds Sin3p in two-hybrid assay Zinc finger (6-Cys) SAKL0H01980g 0 195237 196715 ON 8 H01980 complement(195237..196715) similar to uniprot|Q756H4 Ashbya gossypii AER292C AER292Cp and some similarities with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins SAKL0H02002g 0 196780 197223 ON 8 H02002 complement(196780..197223) similar to uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2 SAKL0H02024g 0 197621 198934 ON 8 H02024 complement(197621..198934) highly similar to uniprot|P00924 Saccharomyces cerevisiae YGR254W ENO1 Enolase I and to uniprot|P00925 Saccharomyces cerevisiae YHR174W ENO2 Enolase II SAKL0H02046g 0 199589 201991 ON 8 H02046 complement(199589..201991) similar to uniprot|P38863 YHR172W Saccharomyces cerevisiae SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex SAKL0H02068g 1 202802 203587 ON 8 H02068 (202802..203587) highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta SAKL0H02101g 0 205268 206587 ON 8 H02101 complement(205268..206587) highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase SAKL0H02112g 0 206731 208623 ON 8 H02112 complement(206731..208623) similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes SAKL0H02134g 0 208856 210412 ON 8 H02134 complement(208856..210412) highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex SAKL0H02156g 0 210640 211194 ON 8 H02156 complement(210640..211194) similar to gnl|GLV|CAGL0I02376g Candida glabrata CAGL0I02376g and weakly similar to YGR251W uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability SAKL0H02178g 0 211451 212758 ON 8 H02178 complement(211451..212758) highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit SAKL0H02200g 0 212928 214550 ON 8 H02200 complement(212928..214550) similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly SAKL0H02222g 0 215347 216162 ON 8 H02222 complement(215347..216162) similar to uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation SAKL0H02244g 1 216327 218213 ON 8 H02244 (216327..218213) similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition SAKL0H02266g 1 218732 226012 ON 8 H02266 (218732..226012) highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing SAKL0H02288g 1 226781 228031 ON 8 H02288 (226781..228031) conserved hypothetical protein SAKL0H02310g 1 228583 233112 ON 8 H02310 (228583..233112) similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate SAKL0H02332g 1 233859 236312 ON 8 H02332 (233859..236312) some similarities with uniprot|P53316 Saccharomyces cerevisiae YGR250C Hypothetical ORF SAKL0H02354g 0 236815 237972 ON 8 H02354 complement(236815..237972) some similarities with uniprot|P53050 Saccharomyces cerevisiae YGR249W SAKL0H02376g 0 238421 239188 ON 8 H02376 complement(238421..239188) similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W SOL3 Glucose-6-phosphate dehydrogenase weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p SAKL0H02398g 0 239663 240307 ON 8 H02398 complement(239663..240307) similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression SAKL0H02420g 1 240720 242543 ON 8 H02420 (240720..242543) similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB SAKL0H02442g 1 242615 245020 ON 8 H02442 (242615..245020) highly similar to gnl|GLV|CAGL0F08129g Candida glabrata CAGL0F08129g and similar to YGR245C uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin SAKL0H02464g 1 245357 246607 ON 8 H02464 (245357..246607) highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate SAKL0H02486g 0 247612 248306 ON 8 H02486 complement(247612..247974,248232..248306) similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43 SAKL0H02508g 1 249432 249920 ON 8 H02508 (249432..249920) no similarity SAKL0H02530g 1 250148 252157 ON 8 H02530 (250148..252157) weakly similar to uniprot|P53309 Saccharomyces cerevisiae YGR241C YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; member of clathrin assembly polypeptide AP180 family and weakly similar to uniprot|P38856 Saccharomyces cerevisiae YHR161C YAP1801 Yeast Assembly Polypeptide member of AP180 protein family binds Pan1p and clathrin clathrin assembly protein SAKL0H02552g 1 253331 256276 ON 8 H02552 (253331..256276) highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6- bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes SAKL0H02574g 1 256880 257803 ON 8 H02574 (256880..257803) weakly similar to uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 Part of a two-member peroxin family (Pex18p and Pex21p) specifically required for peroxisomal targeting of the Pex7p peroxisomal signal recognition factor and PTS2-type peroxisomal matrix proteins SAKL0H02596g 0 258079 259290 ON 8 H02596 complement(258079..259290) weakly similar to uniprot|P38854 Saccharomyces cerevisiae YHR159W Protein of unknown function that localizes to the cytoplasm potential Cdc28p substrate SAKL0H02618g 1 259684 262941 ON 8 H02618 (259684..262941) similar to uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate SAKL0H02640g 0 263084 263611 ON 8 H02640 complement(263084..263611) no similarity SAKL0H02662g 1 264287 266446 ON 8 H02662 (264287..266446) some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF SAKL0H02684g 1 266883 267338 ON 8 H02684 (266883..267338) conserved hypothetical protein SAKL0H02706g 1 268843 272661 ON 8 H02706 (268843..272661) similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase SAKL0H02728g 0 272748 273419 ON 8 H02728 complement(272748..273419) conserved hypothetical protein SAKL0H02750g 1 273630 275960 ON 8 H02750 (273630..275960) highly similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs SAKL0H02772g 1 276392 278422 ON 8 H02772 (276392..278422) similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting SAKL0H02794g 0 278687 278869 ON 8 H02794 complement(278687..278869) highly similar to spP07255 uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain SAKL0H02816g 1 279163 279387 ON 8 H02816 (279163..279387) similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain SAKL0H02838g 0 279590 280594 ON 8 H02838 complement(279590..280594) similar to gnl|GLV|KLLA0B03333g Kluyveromyces lactis KLLA0B03333g and some similarites with YLR394W uniprot|Q06032 Saccharomyces cerevisiae YLR394W CST9 Protein required for synaptonemal complex formation may have a role in meiotic recombination localizes to synapsis initiation sites on meiotic chromosomes potential Cdc28p substrate SAKL0H02860g 1 280944 282209 ON 8 H02860 (280944..282209) highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha- ketoglutarate to biosynthetic processes Sklu_8.trna4W 0 282371 282474 ON 8 tW-CCA complement(282371..282406,282439..282474) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 65.35 Sklu_YGOB_KLTH0D14454g 0 283277 283462 ON 8 KLTH0D14454g complement(283277..283462) ANNOTATED BY YGOB - SAKL0H02970g 0 283656 284486 ON 8 H02970 complement(283656..284486) similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6 SAKL0H02992g 1 284798 286162 ON 8 H02992 (284798..286162) similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C Hypothetical ORF SAKL0H03014g 0 286345 287121 ON 8 H03014 complement(286345..287121) some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response protein SAKL0H03036g 0 287706 288578 ON 8 H03036 complement(287706..288578) similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly- synthesized class I peroxisomal membrane proteins SAKL0H03058g 1 288751 289286 ON 8 H03058 (288751..288788,288851..289286) highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) SAKL0H03080g 0 289374 291245 ON 8 H03080 complement(289374..291245) similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C SAKL0H03102g 0 291464 291724 ON 8 H03102 complement(291464..291724) some similarities with uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Non-essential protein of unknown function SAKL0H03124g 1 291984 295004 ON 8 H03124 (291984..295004) similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family SAKL0H03146g 0 295672 295842 ON 8 H03146 complement(295672..295842) highly similar to uniprot|P41057 Saccharomyces cerevisiae YLR388W RPS29A and to uniprot|P41058 Saccharomyces cerevisiae YDL061C RPS29B Proteins component of the small (40S) ribosomal subunit SAKL0H03168g 1 296695 299076 ON 8 H03168 (296695..299076) similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre- rRNA in the cytoplasm associates with pre-40S ribosomal particles SAKL0H03190g 1 299296 300615 ON 8 H03190 (299296..300615) similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Protein of unknown function, similar to Rei1p but not involved in bud growth SAKL0H03212g 0 300677 303429 ON 8 H03212 complement(300677..303369,303426..303429) similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p SAKL0H03234g 1 303571 303945 ON 8 H03234 (303571..303945) similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7 SAKL0H03256g 1 304143 308132 ON 8 H03256 (304143..308132) highly similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin SAKL0H03278g 0 308223 308840 ON 8 H03278 complement(308223..308840) similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double- strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA SAKL0H03300g 1 309151 314274 ON 8 H03300 (309151..314274) similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene SAKL0H03322g 0 314365 317700 ON 8 H03322 complement(314365..317700) similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination SAKL0H03344g 1 318176 320833 ON 8 H03344 (318176..320833) similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance SAKL0H03366g 0 320889 322994 ON 8 H03366 complement(320889..322994) weakly similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules SAKL0H03388g 0 323232 324554 ON 8 H03388 complement(323232..324554) similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance SAKL0H03410g 1 325527 327383 ON 8 H03410 (325527..327383) similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF SAKL0H03432g 1 327806 330037 ON 8 H03432 (327806..330037) similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes SAKL0H03454g 0 330289 331380 ON 8 H03454 complement(330289..331380) highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure SAKL0H03476g 0 332001 333842 ON 8 H03476 complement(332001..333842) similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport SAKL0H03498g 1 335865 337664 ON 8 H03498 (335865..337664) similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport Sklu_8.trna5K 1 339057 339146 ON 8 tK-UUU (339057..339093,339111..339146) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 SAKL0H03652g 0 339232 341208 ON 8 H03652 complement(339232..341208) conserved hypothetical protein SAKL0H03674g 1 341526 342275 ON 8 H03674 (341526..342275) weakly similar to uniprot|Q2JS38 Yellowstone A- Prime) CYA_2425 ISSoc2 resolvase SAKL0H03696g 0 342849 344291 ON 8 H03696 complement(342849..344291) highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER SAKL0H03718g 0 344699 346072 ON 8 H03718 complement(344699..346072) similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C SAKL0H03729g 0 346385 346804 ON 8 H03729 complement(346385..346804) some similarities with uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)- binding protein Pab1p SAKL0H03740g 1 348274 349311 ON 8 H03740 (348274..349311) highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism SAKL0H03762g 0 349686 350702 ON 8 H03762 complement(349686..350702) similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase SAKL0H03806g 1 351287 352054 ON 8 H03806 (351287..352054) similar to gnl|GLV|CAGL0H04895g Candida glabrata CAGL0H04895g and weakly similar to YLR376C uniprot|Q12318 Saccharomyces cerevisiae YLR376C PSY3 Protein of unknown function deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C SAKL0H03828g 1 352477 353307 ON 8 H03828 (352477..353307) similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein SAKL0H03850g 0 353754 354722 ON 8 H03850 complement(353754..354722) similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects SAKL0H03872g 1 355841 357091 ON 8 H03872 (355841..357091) conserved hypothetical protein SAKL0H03894g 0 357602 358678 ON 8 H03894 complement(357602..358678) similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids SAKL0H03916g 1 362450 365092 ON 8 H03916 (362450..365092) similar to Saccharomyces cerevisiae YLR373C VID22 Vacuole import and degradation and to uniprot|P53246 Saccharomyces cerevisiae YGR071C Hypothetical ORF SAKL0H03938g 0 365757 366785 ON 8 H03938 complement(365757..366785) similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis SAKL0H03960g 0 367001 370762 ON 8 H03960 complement(367001..370762) similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP SAKL0H03982g 1 371133 371737 ON 8 H03982 (371133..371138,371213..371737) highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches SAKL0H04004g 0 371864 373807 ON 8 H04004 complement(371864..373807) highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins SAKL0H04026g 0 374032 375831 ON 8 H04026 complement(374032..375831) weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 Protein involved in determination of mitochondrial structure SAKL0H04048g 1 376399 378525 ON 8 H04048 (376399..378525) similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C Hypothetical ORF SAKL0H04070g 1 379179 381878 ON 8 H04070 (379179..381878) some similarities with uniprot|P53243 Saccharomyces cerevisiae YGR067C hypothetical ORF SAKL0H04092g 0 382049 382764 ON 8 H04092 complement(382049..382308,382632..382764) highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and highly similar to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit SAKL0H04114g 1 384675 386471 ON 8 H04114 (384675..386471) highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter SAKL0H04136g 0 386608 386940 ON 8 H04136 complement(386608..386940) similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W Hypothetical ORF SAKL0H04158g 1 387323 387628 ON 8 H04158 (387323..387628) highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation and plays a role in pre-mRNA processing in addition Spt4p is involved in kinetochore function and gene silencing SAKL0H04180g 1 387869 388861 ON 8 H04180 (387869..388861) similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C SAKL0H04202g 0 389152 389412 ON 8 H04202 complement(389152..389412) similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Hypothetical ORF SAKL0H04224g 1 390622 394674 ON 8 H04224 (390622..394674) highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway SAKL0H04246g 0 395105 396037 ON 8 H04246 complement(395105..396037) highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol SAKL0H04268g 1 397084 397764 ON 8 H04268 (397084..397764) similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway SAKL0H04312g 0 398688 400355 ON 8 H04312 complement(398688..400355) similar to uniprot|P41901 Saccharomyces cerevisiae YGR059W SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes regulated by ABFI septin protein involved in sporulation SAKL0H04334g 0 400661 401858 ON 8 H04334 complement(400661..401746,401814..401858) similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W Hypothetical ORF SAKL0H04356g 0 402212 402877 ON 8 H04356 complement(402212..402477,402826..402877) highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit SAKL0H04378g 1 403363 404370 ON 8 H04378 (403363..404370) similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Hypothetical ORF SAKL0H04400g 0 404481 408893 ON 8 H04400 complement(404481..408893) similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W Hypothetical ORF SAKL0H04422g 1 409781 414943 ON 8 H04422 (409781..414943) similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs SAKL0H04444g 1 415574 417019 ON 8 H04444 (415574..417019) conserved hypothetical protein SAKL0H04466g 0 417106 418122 ON 8 H04466 complement(417106..418122) uniprot|P87292 Saccharomyces kluyveri MTF1 Mitochondrial replication protein MTF1 SAKL0H04488g 1 418323 420158 ON 8 H04488 (418323..420158) similar to uniprot|Q752L1 Ashbya gossypii AFR563C AFR563Cp and weakly similar to YMR227C uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation SAKL0H04510g 0 420169 420720 ON 8 H04510 complement(420169..420720) conserved hypothetical protein SAKL0H04532g 1 420999 426025 ON 8 H04532 (420999..421052,421145..426025) similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator SAKL0H04631g2 0 430996 432318 ON 8 H04631 complement(430996..432318) Retrotransposon Gag gene Sklu_8.trna6A 1 432873 432945 ON 8 tA-UGC (432873..432945) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 73.87 SAKL0H04730g 1 433425 434231 ON 8 H04730 (433425..434231) highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP( )-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids Sklu_8.trna7T 0 434370 434442 ON 8 tT-AGU complement(434370..434442) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 SAKL0H04796g 0 435127 435801 ON 8 H04796 complement(435127..435801) similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF SAKL0H04818g 1 436005 436934 ON 8 H04818 (436005..436934) similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family overexpression suppresses the defect in maturation of carboxypeptidase Y and defects in other essential Pdi1p functions caused by PDI1 deletion SAKL0H04840g 1 437103 437481 ON 8 H04840 (437103..437160,437225..437481) similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit SAKL0H04862g 1 437805 438773 ON 8 H04862 (437805..438773) similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability SAKL0H04884g 0 438839 439255 ON 8 H04884 complement(438839..439255) similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF SAKL0H04906g 1 440075 440488 ON 8 H04906 (440075..440488) similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF SAKL0H04928g 0 441255 441947 ON 8 H04928 complement(441255..441947) highly similar to gnl|GLV|KLLA0C06908g Kluyveromyces lactis KLLA0C06908g and similar to YOR283W uniprot|Q12040 Saccharomyces cerevisiae YOR283W Hypothetical ORF SAKL0H04950g 1 442113 444152 ON 8 H04950 (442113..444152) similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double- strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved SAKL0H04972g 1 444307 445158 ON 8 H04972 (444307..445158) similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C SAKL0H04994g 0 445232 446596 ON 8 H04994 complement(445232..446596) similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex required for SAGA-mediated deubiquitination of histone H2B SAKL0H05016g 1 447930 448700 ON 8 H05016 (447930..448700) similar to Saccharomyces cerevisiae and to YMR222C uniprot|Q05015 Saccharomyces cerevisiae FSH2 Serine hydrolase SAKL0H05038g 1 449396 450958 ON 8 H05038 (449396..450958) similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria SAKL0H05060g 1 451288 452265 ON 8 H05060 (451288..452265) weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p SAKL0H05082g 0 452373 453713 ON 8 H05082 complement(452373..453713) similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate SAKL0H05104g 0 454375 459372 ON 8 H05104 complement(454375..459372) weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery involved in telomeric silencing interacts with PAD4-domain of Sir4p SAKL0H05126g 1 459518 462802 ON 8 H05126 (459518..462802) similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic SAKL0H05148g 0 462852 463634 ON 8 H05148 complement(462852..463634) similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway SAKL0H05170g 0 463980 465557 ON 8 H05170 complement(463980..465557) highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation SAKL0H05192g 1 466582 467632 ON 8 H05192 (466582..466661,466747..467632) conserved hypothetical protein SAKL0H05214g 1 468419 470185 ON 8 H05214 (468419..470185) similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C SAKL0H05236g 0 471846 473366 ON 8 H05236 complement(471846..473366) similar to uniprot|Q03655 Saccharomyces cerevisiae YMR215W GAS3 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall SAKL0H05258g 0 474006 475112 ON 8 H05258 complement(474006..475112) similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog SAKL0H05280g 0 475524 475997 ON 8 H05280 complement(475524..475997) similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control repressor of cap- dependent translation initiation competes with eIF4G for binding to eIF4E SAKL0H05302g 0 476146 477861 ON 8 H05302 complement(476146..477861) similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p SAKL0H05324g 1 478049 480217 ON 8 H05324 (478049..480217) similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery SAKL0H05346g 1 480397 482379 ON 8 H05346 (480397..482379) similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation SAKL0H05368g 0 482406 483707 ON 8 H05368 complement(482406..483707) similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms SAKL0H05390g 0 483842 485293 ON 8 H05390 complement(483842..485293) similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W SAKL0H05412g 1 486897 488639 ON 8 H05412 (486897..488639) similar to uniprot|Q12256 Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein SAKL0H05434g 1 489234 490517 ON 8 H05434 (489234..490517) similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF SAKL0H05456g 0 490546 491886 ON 8 H05456 complement(490546..491886) highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein SAKL0H05478g 1 493087 494070 ON 8 H05478 (493087..494070) highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF SAKL0H05500g 0 494181 495425 ON 8 H05500 complement(494181..495425) similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate SAKL0H05522g 0 496278 496697 ON 8 H05522 complement(496278..496697) no similarity SAKL0H05544g 1 497300 499765 ON 8 H05544 (497300..499765) similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V- ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes SAKL0H05566g 0 500251 501663 ON 8 H05566 complement(500251..501663) similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1 SAKL0H05588g 1 502752 504602 ON 8 H05588 (502752..504602) similar to gnl|GLV|CAGL0C02893g Candida glabrata CAGL0C02893g and some similarites with YOR267C uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H( )- ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis SAKL0H05610g 0 504724 505980 ON 8 H05610 complement(504724..505980) similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein SAKL0H05632g 0 506408 506731 ON 8 H05632 complement(506408..506731) highly similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta- tubulin SAKL0H05654g 0 507249 508532 ON 8 H05654 complement(507249..508532) weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate SAKL0H05676g 0 509057 510100 ON 8 H05676 complement(509057..510100) highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability SAKL0H05698g 1 510519 511517 ON 8 H05698 (510519..511517) similar to uniprot|Q08723 Saccharomyces cerevisiae YOR261C non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p SAKL0H05720g 1 511687 513045 ON 8 H05720 (511687..513045) similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders SAKL0H05742g 0 513158 514660 ON 8 H05742 complement(513158..514660) similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression SAKL0H05764g 1 514898 516163 ON 8 H05764 (514898..516163) highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle SAKL0H05786g 0 516216 516857 ON 8 H05786 complement(516216..516857) similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia SAKL0H05808g 0 517240 518121 ON 8 H05808 complement(517240..518121) highly similar to gnl|GLV|KLLA0C09647g Kluyveromyces lactis KLLA0C09647g and similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit SAKL0H05830g 0 518357 518878 ON 8 H05830 complement(518357..518878) highly similar to gnl|GLV|KLLA0C09669g Kluyveromyces lactis KLLA0C09669g and similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p SAKL0H05852g 1 519004 521613 ON 8 H05852 (519004..521613) weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued) SAKL0H05874g 0 521657 523037 ON 8 H05874 complement(521657..522956,523021..523037) similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates I) SAKL0H05896g 1 523201 525552 ON 8 H05896 (523201..525552) similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C SAKL0H05918g 1 526051 526506 ON 8 H05918 (526051..526506) highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis SAKL0H05940g 0 526620 527618 ON 8 H05940 complement(526620..527618) weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers SAKL0H05962g 0 528250 529974 ON 8 H05962 complement(528250..529974) similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP SAKL0H05984g 1 530194 532170 ON 8 H05984 (530194..532170) similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post- translational SRP-independent protein targeting and import into the ER SAKL0H06006g 0 532245 532754 ON 8 H06006 complement(532245..532754) similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing SAKL0H06028g 1 532884 534101 ON 8 H06028 (532884..534101) some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W Hypothetical ORF SAKL0H06050g 0 534156 534725 ON 8 H06050 complement(534156..534725) highly similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF SAKL0H06072g 0 534860 539407 ON 8 H06072 complement(534860..539407) similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage SAKL0H06094g 1 539542 540060 ON 8 H06094 (539542..540060) similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0H06116g 0 540037 541194 ON 8 H06116 complement(540037..541194) similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6 SAKL0H06138g 1 542102 543016 ON 8 H06138 (542102..543016) highly similar to gnl|GLV|CAGL0K09064g Candida glabrata CAGL0K09064g and similar to YOR251C uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate SAKL0H06160g 1 543193 544524 ON 8 H06160 (543193..544524) similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit SAKL0H06182g 1 545015 547102 ON 8 H06182 (545015..547102) weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition SAKL0H06204g 0 547190 549502 ON 8 H06204 complement(547190..549502) similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability SAKL0H06226g 0 550025 550546 ON 8 H06226 complement(550025..550546) conserved hypothetical protein SAKL0H06248g 0 551422 552246 ON 8 H06248 complement(551422..552246) similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Hypothetical ORF SAKL0H06270g 0 552616 554412 ON 8 H06270 complement(552616..554412) similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p SAKL0H06292g 1 554977 555957 ON 8 H06292 (554977..555957) similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases SAKL0H06314g 0 556470 557216 ON 8 H06314 complement(556470..557216) similar to uniprot|Q2JS38 Yellowstone A-Prime) CYA_2425 ISSoc2 resolvase SAKL0H06336g 1 557522 560812 ON 8 H06336 (557522..560812) highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA SAKL0H06358g 1 562681 563007 ON 8 H06358 (562681..563007) conserved hypothetical protein SAKL0H06380g 0 563753 564412 ON 8 H06380 complement(563753..564412) similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome SAKL0H06402g 1 564751 566079 ON 8 H06402 (564751..566079) similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF and weakly similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YBR177c uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase, may be involved in lipid metabolism, null mutant slightly temperature sensitive at 37C SAKL0H06424g 0 566194 568086 ON 8 H06424 complement(566194..568086) weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF SAKL0H06446g 1 568689 569609 ON 8 H06446 (568689..569609) similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase SAKL0H06468g 0 569965 570741 ON 8 H06468 complement(569965..570741) weakly similar to uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein predicted to have 1 transmembrane segment transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift SAKL0H06490g 0 571300 573273 ON 8 H06490 complement(571300..573273) similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning SAKL0H06512g 0 573927 575141 ON 8 H06512 complement(573927..575141) highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates SAKL0H06534g 0 575439 577853 ON 8 H06534 complement(575439..577853) similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p SAKL0H06556g 0 578066 580309 ON 8 H06556 complement(578066..580309) some similarities with uniprot|P36044 Saccharomyces cerevisiae YKL201C MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases SAKL0H06578g 1 580650 582029 ON 8 H06578 (580650..582029) similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles SAKL0H06600g 0 582530 583276 ON 8 H06600 complement(582530..583276) similar to uniprot|Q2JS38 Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) ISSoc2 resolvase SAKL0H06622g 1 583484 584551 ON 8 H06622 (583484..584551) similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W SAKL0H06644g 0 584605 585924 ON 8 H06644 complement(584605..585924) highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression SAKL0H06666g 0 586110 587435 ON 8 H06666 complement(586110..587435) highly similar to uniprot|Q75BY3 Ashbya gossypii ACR137W PRP46 Pre-mRNA-splicing factor PRP46 and similar to YPL151C uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome SAKL0H06688g 1 588445 590481 ON 8 H06688 (588445..590481) similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35 SAKL0H06710g 1 590840 592165 ON 8 H06710 (590840..592165) similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation SAKL0H06732g 0 592276 593763 ON 8 H06732 complement(592276..593763) highly similar to gnl|GLV|KLLA0F11297g Kluyveromyces lactis KLLA0F11297g and similar to YOR241W uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria SAKL0H06754g 1 594995 597649 ON 8 H06754 (594995..597649) similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Hypothetical ORF SAKL0H06776g 0 597759 599312 ON 8 H06776 complement(597759..599312) conserved hypothetical protein SAKL0H06798g 1 599425 600309 ON 8 H06798 (599425..600309) similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation Sklu_YGOB_Anc_8.665 0 600377 602225 ON 8 Anc_8.665 complement(600377..601444,601446..602225) ANNOTATED BY YGOB - SAKL0H06842g 0 602542 603090 ON 8 H06842 complement(602542..603090) similar to gnl|GLV|KLLA0F11418g Kluyveromyces lactis KLLA0F11418g and weakly similar to YPL148C uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation SAKL0H06864g 0 603330 604004 ON 8 H06864 complement(603330..604004) conserved hypothetical protein SAKL0H06886g 0 604406 605269 ON 8 H06886 complement(604406..605269) conserved hypothetical protein SAKL0H06908g 1 605838 608348 ON 8 H06908 (605838..608348) similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter SAKL0H06930g 0 608421 609299 ON 8 H06930 complement(608421..609299) similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Hypothetical ORF SAKL0H06952g 0 609523 610884 ON 8 H06952 complement(609523..610884) similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired SAKL0H06974g 0 611498 612757 ON 8 H06974 complement(611498..612757) highly similar to gnl|GLV|KLLA0D07480g Kluyveromyces lactis KLLA0D07480g and similar to YPL145C uniprot|P35844 Saccharomyces cerevisiae YPL145C KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p- dependent Golgi complex secretory functions peripheral membrane protein that localizes to the Golgi complex SAKL0H06996g 0 613092 613886 ON 8 H06996 complement(613092..613886) similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function Sklu_YGOB_Anc_8.656 1 613898 614320 ON 8 Anc_8.656 (613898..614320) ANNOTATED BY YGOB - Search-DOGS addition SAKL0H07018g 1 614576 616600 ON 8 H07018 (614576..616600) conserved hypothetical protein SAKL0H07062g 1 618124 618949 ON 8 H07062 (618124..618142,618645..618949) highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W, RPL33A Ribosomal Protein of the Large subunit SAKL0H07084g 0 619288 622047 ON 8 H07084 complement(619288..622047) weakly similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C Hypothetical ORF SAKL0H07106g 0 622764 623492 ON 8 H07106 complement(622764..623492) similar to uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria SAKL0H07128g 0 623681 625141 ON 8 H07128 complement(623681..625141) similar to uniprot|P32491 Saccharomyces cerevisiae YPL140C MKK2 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk1p SAKL0H07150g 0 626019 627430 ON 8 H07150 complement(626019..627341,627428..627430) weakly similar to uniprot|Q12206 YOR229W Saccharomyces cerevisiae WTM2 WD repeat containing transcriptional modulator 2 SAKL0H07172g 0 627688 628692 ON 8 H07172 complement(627688..628692) similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C SAKL0H07194g 1 628863 629753 ON 8 H07194 (628863..629753) similar to Q12106 YOR228C uniprot|Q12106 Saccharomyces cerevisiae Hypothetical ORF SAKL0H07216g 0 629989 633627 ON 8 H07216 complement(629989..633627) similar to uniprot|Q12276 Saccharomyces cerevisiae YOR227W Hypothetical ORF SAKL0H07238g 1 634411 634863 ON 8 H07238 (634411..634863) highly similar to uniprot|Q75C07 Ashbya gossypii ACR112C ISU1 Iron sulfur cluster assembly protein 1 mitochondrial precursor and similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W ISU1 Conserved protein of the mitochondrial matrix SAKL0H07260g 1 635843 636277 ON 8 H07260 (635843..636277) highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5 common to RNA polymerases I II and III SAKL0H07282g 1 637092 637727 ON 8 H07282 (637092..637727) conserved hypothetical protein SAKL0H07304g 0 637736 638497 ON 8 H07304 complement(637736..638497) similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF SAKL0H07326g 0 639197 640090 ON 8 H07326 complement(639197..640090) similar to uniprot|Q99297 Saccharomyces cerevisiae YOR222W ODC2 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism SAKL0H07348g 1 640522 641484 ON 8 H07348 (640522..641484) similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling SAKL0H07370g 0 641801 642982 ON 8 H07370 complement(641801..642982) similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator SAKL0H07392g 1 643214 644011 ON 8 H07392 (643214..644011) similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase SAKL0H07414g 0 644334 644990 ON 8 H07414 complement(644334..644990) similar to uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF SAKL0H07436g 1 645924 646817 ON 8 H07436 (645924..646817) highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit SAKL0H07458g 1 647256 649898 ON 8 H07458 (647256..649898) similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a-factor Sklu_8.trna8K 0 650082 650171 ON 8 tK-UUU complement(650082..650117,650135..650171) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 SAKL0H07502g 0 650824 653406 ON 8 H07502 complement(650824..653406) similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon SAKL0H07524g 1 653641 654999 ON 8 H07524 (653641..654999) similar to Q12234 YOR216C uniprot|Q12234 Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi SAKL0H07546g 1 655425 655982 ON 8 H07546 (655425..655982) similar to Q12032 YOR215C uniprot|Q12032 Saccharomyces cerevisiae Hypothetical ORF SAKL0H07568g 1 656264 657007 ON 8 H07568 (656264..657007) similar to uniprot|Q12282 Saccharomyces cerevisiae YOR214C Hypothetical ORF SAKL0H07590g 1 657369 658010 ON 8 H07590 (657369..658010) highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain SAKL0H07612g 1 658366 659092 ON 8 H07612 (658366..658374,658436..659092) similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain SAKL0H07656g 0 659189 660469 ON 8 H07656 complement(659189..660469) similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit SAKL0H07678g 0 661006 662622 ON 8 H07678 complement(661006..662622) similar to uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor Sklu_8.trna9D 0 662752 662823 ON 8 tD-GUC complement(662752..662823) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0H07744g 1 664013 664748 ON 8 H07744 (664013..664094,664186..664748) similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1 a linker histone required for nucleosome packaging at restricted sites suppresses DNA repair involving homologous recombination not required for telomeric silencing basal transcriptional repression or efficient sporulation SAKL0H07788g 1 666161 668815 ON 8 H07788 (666161..668815) similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p SAKL0H07810g 0 668958 669170 ON 8 H07810 complement(668958..669170) highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III SAKL0H07832g 1 669398 671995 ON 8 H07832 (669398..671995) similar to uniprot|Q02931 Saccharomyces cerevisiae YPL126W NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3 SAKL0H07854g 1 672653 673942 ON 8 H07854 (672653..673942) highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase SAKL0H07876g 1 674192 677290 ON 8 H07876 (674192..677290) highly similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits SAKL0H07898g 0 677463 680021 ON 8 H07898 complement(677463..680021) similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus SAKL0H07920g 1 681287 681970 ON 8 H07920 (681287..681970) some similarities with uniprot|P33419 Saccharomyces cerevisiae YPL124W SPC29 Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication SAKL0H07942g 0 682058 683362 ON 8 H07942 complement(682058..683362) similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases SAKL0H07964g 0 684332 686965 ON 8 H07964 complement(684332..686965) highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits SAKL0H07986g 0 687202 688569 ON 8 H07986 complement(687202..688569) uniprot|Q4A1B8 Saccharomyces kluyveri atg6 Beclin 1 SAKL0H08008g 0 689115 690770 ON 8 H08008 complement(689115..690770) similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria SAKL0H08030g 1 690978 693113 ON 8 H08030 (690978..693113) similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre- ribosomes both complexes mediate intranuclear transport of ribosomal precursors SAKL0H08052g 1 693425 694174 ON 8 H08052 (693425..694174) weakly similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination forms heterodimer with Sae3p proposed to be an assembly factor for Dmc1p SAKL0H08074g 0 694259 697690 ON 8 H08074 complement(694259..697690) highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III which is responsible for the transcription of tRNA and 5S RNA genes and other low molecular weight RNAs SAKL0H08096g 1 698150 699673 ON 8 H08096 (698150..699673) highly similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C Sklu_8.trna10C 0 700772 700843 ON 8 tC-GCA complement(700772..700843) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.27 SAKL0H08162g 0 702292 704166 ON 8 H08162 complement(702292..704166) similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase required for translation initiation of all yeast mRNAs mutations in human DEAD-box DBY are a frequent cause of male infertility SAKL0H08184g 1 704748 706544 ON 8 H08184 (704748..706544) similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids SAKL0H08206g 1 706959 708014 ON 8 H08206 (706959..708014) similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the large subunit MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences SAKL0H08228g 0 708153 708851 ON 8 H08228 complement(708153..708851) uniprot|Q02986 Saccharomyces kluyveri HIS3 Imidazoleglycerol-phosphate dehydratase SAKL0H08250g 1 709141 710355 ON 8 H08250 (709141..710355) similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical conserved nucleotide in mitochondrial 21S rRNA SAKL0H08272g 0 710527 711357 ON 8 H08272 complement(710527..711357) highly similar to gnl|GLV|CAGL0J06952g Candida glabrata CAGL0J06952g and similar to YPL117C uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) catalyzes an essential activation step in the isoprenoid biosynthetic pathway required for viability SAKL0H08294g 1 713096 714484 ON 8 H08294 (713096..714484) similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes implicated in secretion and nuclear segregation multicopy suppressor of BFA (Brefeldin A) sensitivity SAKL0H08316g 0 714801 716060 ON 8 H08316 complement(714801..716060) similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases SAKL0H08338g 1 716414 718486 ON 8 H08338 (716414..718486) similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) SAKL0H08360g 1 719919 720161 ON 8 H08360 (719919..720161) conserved hypothetical protein SAKL0H08382g 1 721973 723127 ON 8 H08382 (721973..723127) highly similar to uniprot|Q74ZH6 Ashbya gossypii AGR231C AGR231Cp and highly similar to YOR196C uniprot|P32875 Saccharomyces cerevisiae SAKL0H08404g 0 723313 726621 ON 8 H08404 complement(723313..726621) similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization targets the essential Rho-GTPase Cdc42p which controls establishment and maintenance of cell polarity including bud-site assembly SAKL0H08426g 0 726923 729373 ON 8 H08426 complement(726923..729373) weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis component of the FEAR regulatory network which promotes Cdc14p release from the nucleolus during anaphase potential Cdc28p substrate SAKL0H08448g 1 729801 730436 ON 8 H08448 (729801..730436) similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 Transcription factor IIA large chain SAKL0H08470g 0 730657 731829 ON 8 H08470 complement(730657..731829) similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase SAKL0H08492g 0 732040 733221 ON 8 H08492 complement(732040..733221) similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p Sklu_8.trna11M 0 733398 733469 ON 8 tM-CAU complement(733398..733469) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.91 SAKL0H08536g 1 735213 736175 ON 8 H08536 (735213..736175) highly similar to gnl|GLV|KLLA0F00704g Kluyveromyces lactis KLLA0F00704g and similar to YPL111W uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase responsible for arginine degradation expression responds to both induction by arginine and nitrogen catabolite repression disruption enhances freeze tolerance SAKL0H08558g 1 736928 737332 ON 8 H08558 (736928..737332) conserved hypothetical protein SAKL0H08580g 0 737581 741684 ON 8 H08580 complement(737581..741684) similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C Hypothetical ORF SAKL0H08602g 0 742211 744070 ON 8 H08602 complement(742211..744070) similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Hypothetical ORF SAKL0H08624g 0 744555 745106 ON 8 H08624 complement(744555..745106) highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP- ribosylation factor SAKL0H08646g 1 745368 746078 ON 8 H08646 (745368..746078) some similarities with uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity SAKL0H08668g 0 746386 747723 ON 8 H08668 complement(746386..747723) highly similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Step of tyrosine biosynthesis pathway Prephenate dehydrogenase (NADP ) SAKL0H08690g 1 748111 748719 ON 8 H08690 (748111..748719) similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation expression sensitive to nitrogen catabolite repression SAKL0H08712g 1 749157 749732 ON 8 H08712 (749157..749732) similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Hypothetical ORF SAKL0H08734g 0 749863 750327 ON 8 H08734 complement(749863..750327) similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0H08756g 1 750494 751672 ON 8 H08756 (750494..751672) similar to uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein involved in negative regulation of peroxisome size partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p SAKL0H08778g 1 751878 752666 ON 8 H08778 (751878..752666) similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Hypothetical ORF SAKL0H08800g 1 753145 755007 ON 8 H08800 (753145..755007) similar to uniprot|Q74ZI9 Ashbya gossypii AGR213C AGR213Cp and weakly similar to YPR003C uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF SAKL0H08822g 0 755179 757260 ON 8 H08822 complement(755179..757260) uniprot|Q875P5 Saccharomyces kluyveri SSE1 Heat shock protein homolog SSE1 SAKL0H08844g 0 757780 759555 ON 8 H08844 complement(757780..759555) highly similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Endoplasmic reticulum and nuclear membrane protein forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation SAKL0H08866g 1 759703 760323 ON 8 H08866 (759703..760323) similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER SAKL0H08888g 0 760444 762750 ON 8 H08888 complement(760444..762750) weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C SMY2 partial suppressor of myo2-66 Kinesin-related protein suppressing myosin defects (MYO2) and to uniprot|Q02875 YPL105c SAKL0H08910g 0 763018 763464 ON 8 H08910 complement(763018..763464) highly similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome degraded by proteasome upon completion of its assembly involved in ubiquitin-mediated proteolysis mutant defective in degradation of short-lived proteins SAKL0H08932g 1 763703 764647 ON 8 H08932 (763703..764647) similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres SAKL0H08954g 1 765230 767197 ON 8 H08954 (765230..767197) similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene Sklu_8.trna12E 1 768176 768247 ON 8 tE-UUC (768176..768247) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0H09020g 0 768985 770055 ON 8 H09020 complement(768985..770055) similar to gnl|GLV|KLLA0E24442g Kluyveromyces lactis KLLA0E24442g and weakly similar to YGR031W uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF SAKL0H09042g 1 771410 772807 ON 8 H09042 (771410..772807) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport SAKL0H09064g 1 773259 774206 ON 8 H09064 (773259..774206) similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase required for pantothenic acid biosynthesis converts 2- oxoisovalerate into 2-dehydropantoate SAKL0H09086g 0 774264 775682 ON 8 H09086 complement(774264..775682) similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C SAKL0H09108g 1 776073 777467 ON 8 H09108 (776073..777467) similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity SAKL0H09130g 1 778200 779408 ON 8 H09130 (778200..779408) similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphatidylinositol 3 5-bisphosphate- binding protein required for maturation of pro- aminopeptidase I predicted to fold as a seven-bladed beta- propeller displays punctate cytoplasmic localization SAKL0H09152g 0 779444 779953 ON 8 H09152 complement(779444..779953) similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C FMP14 The authentic non-tagged protein was localized to the mitochondria SAKL0H09174g 0 780122 780466 ON 8 H09174 complement(780122..780466) similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C Hypothetical ORF SAKL0H09196g 1 780642 782012 ON 8 H09196 (780642..782012) similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W Sklu_YGOB_Anc_8.576 0 782058 782264 ON 8 Anc_8.576 complement(782058..782264) ANNOTATED BY YGOB - Search-DOGS addition SAKL0H09218g 1 782364 783419 ON 8 H09218 (782364..783419) similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 de-N-glycosylation enzyme peptide:N- glycanase SAKL0H09240g 0 783496 784887 ON 8 H09240 complement(783496..784887) similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase may be involved in lipid metabolism null mutant slightly temperature sensitive at 37C and similar to YPL095c uniprot|Q02891 Saccharomyces cerevisiae YPL095C Hypothetical ORF and weakly similar to YMR210w uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF SAKL0H09262g 0 785089 787587 ON 8 H09262 complement(785089..787587) similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome contains N-terminal GTPase domain SAKL0H09284g 0 788112 788846 ON 8 H09284 complement(788112..788846) similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C SAKL0H09306g 1 789179 791125 ON 8 H09306 (789179..791125) highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis member of the ODN family of nucleolar G-proteins SAKL0H09328g 1 791744 793534 ON 8 H09328 (791744..793534) similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily essential for spore wall synthesis facilitates the translocation of bisformyl dityrosine through the prospore membrane SAKL0H09350g 1 795453 796751 ON 8 H09350 (795453..796751) similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux SAKL0H09372g 1 796939 798387 ON 8 H09372 (796939..798387) highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase converts oxidized glutathione to reduced glutathione SAKL0H09394g 0 798611 799694 ON 8 H09394 complement(798611..799315,799689..799694) highly similar to uniprot|P02365 Saccharomyces cerevisiae YPL090C RPS6A and to uniprot|P02365 Saccharomyces cerevisiae YBR181C RPS6B Proteins component of the small (40S) ribosomal subunit SAKL0H09416g 0 800500 802235 ON 8 H09416 complement(800500..802120,802180..802235) some similarities with uniprot|Q12224 Saccharomyces cerevisiae YPL089C RLM1 MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p SAKL0H09438g 1 803426 804454 ON 8 H09438 (803426..804454) highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance SAKL0H09460g 1 805313 806158 ON 8 H09460 (805313..806158) conserved hypothetical protein SAKL0H09482g 1 806497 807453 ON 8 H09482 (806497..807453) similar to uniprot|Q02896 Saccharomyces cerevisiae YPL087W YDC1 Yeast dihydro-ceramidase alkaline dihydroceramidase with minor reverse activity. SAKL0H09504g 1 808734 810146 ON 8 H09504 (808734..810146) similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis SAKL0H09526g 1 810370 811527 ON 8 H09526 (810370..811527) similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis SAKL0H09548g 0 811686 813359 ON 8 H09548 complement(811686..813359) highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Histone acetyltransferase subunit of the Elongator complex which is a component of the RNA polymerase II holoenzyme activity is directed specifically towards histones H3 and H4 disruption confers resistance to K. lactis zymotoxin SAKL0H09570g 1 813906 820970 ON 8 H09570 (813906..820970) weakly similar to uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes interacts with Sec23p Sec24p and Sec31p SAKL0H09592g 0 821120 821956 ON 8 H09592 complement(821120..821956) highly similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane SAKL0H09614g 1 822147 824675 ON 8 H09614 (822147..824675) similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes SAKL0H09636g 0 824728 826131 ON 8 H09636 complement(824728..826131) similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p Sklu_YGOB_09658g 1 828107 829791 ON 8 09658g (828107..829591,829654..829791) ANNOTATED BY YGOB - SAKL0H09658g 1 828107 829639 OFF 8 H09658 (828107..829639) similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint which prevents chromosome segregation when recombination and chromosome synapsis are defective also represses meiotic interhomolog recombination in the rDNA SAKL0H09680g 1 830060 830902 ON 8 H09680 (830060..830902) similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W Hypothetical ORF SAKL0H09702g 0 831033 831548 ON 8 H09702 complement(831033..831548) no similarity SAKL0H09724g 0 831713 837301 ON 8 H09724 complement(831713..837301) similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription removes Spt15p (TBP) from DNA via its C-terminal ATPase activity forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity SAKL0H09746g 1 838272 839456 ON 8 H09746 (838272..839456) highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase SAKL0H09768g 1 840247 841273 ON 8 H09768 (840247..840253,840708..841273) highly similar to uniprot|O13516 Saccharomyces cerevisiae YPL081W RPS9A and to uniprot|P05755 Saccharomyces cerevisiae YBR189W RPS9B Proteins component of the small (40S) ribosomal subunit SAKL0H09790g 1 842254 843114 ON 8 H09790 (842254..842264,842643..843114) highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W SAKL0H09812g 1 843768 844880 ON 8 H09812 (843768..844880) similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration Probable carrier protein mitochondrial SAKL0H09834g 0 844992 845735 ON 8 H09834 complement(844992..845735) similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex SAKL0H09856g 1 845771 846293 ON 8 H09856 (845771..845798,845857..846293) similar to uniprot|P38305 Saccharomyces cerevisiae YBR194W SOY1 Synthetic with Old Yellow Enzyme SAKL0H09878g 0 846715 847774 ON 8 H09878 complement(846715..847354,847704..847774) similar to gnl|GLV|KLLA0E23639g Kluyveromyces lactis KLLA0E23639g and highly similar to YPL078C uniprot|P05626 Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis SAKL0H09900g 0 847975 849252 ON 8 H09900 complement(847975..849252) similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF- I) regulates the RAS/cAMP pathway via sequestration of Npr1p kinase localizes to the nucleus and cytoplasm homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 SAKL0H09922g 0 849513 851180 ON 8 H09922 complement(849513..851180) highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase catalyzes the interconversion of glucose-6- phosphate and fructose-6-phosphate required for cell cycle progression and completion of the gluconeogenic events of sporulation SAKL0H09944g 0 851569 851976 ON 8 H09944 complement(851569..851976) some similarities with uniprot|Q02831 Saccharomyces cerevisiae YPL077C Hypothetical ORF SAKL0H09966g 1 852158 852982 ON 8 H09966 (852158..852982) similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N- acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-C protein SAKL0H09988g 0 853060 855309 ON 8 H09988 complement(853060..855309) similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification SAKL0H10010g 1 856062 857996 ON 8 H10010 (856062..857996) similar to uniprot|Q758V3 Ashbya gossypii AEL245W AEL245Wp and some similarites with YPL075W uniprot|P07261 Saccharomyces cerevisiae YPL075W GCR1 Transcriptional activator of genes involved in glycolysis functions and interacts with Gcr2p SAKL0H10032g 1 858355 860484 ON 8 H10032 (858355..860484) similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to the cortex of mother cells but not to daughter cells SAKL0H10054g 1 861464 862900 ON 8 H10054 (861464..862900) similar to uniprot|P38131 Saccharomyces cerevisiae YBR199W KTR4 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family SAKL0H10076g 1 863358 865661 ON 8 H10076 (863358..865661) similar to gnl|GLV|KLLA0E23463g Kluyveromyces lactis KLLA0E23463g and some similarites with YPL072W uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Putative ubiquitin-specific protease SAKL0H10098g 1 865874 867645 ON 8 H10098 (865874..865882,865987..867645) similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains involved in establishing cell polarity and morphogenesis functions as a scaffold protein for complexes that include Cdc24p Ste5p Ste20p and Rsr1p SAKL0H10120g 0 867808 868269 ON 8 H10120 complement(867808..868269) similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Hypothetical ORF SAKL0H10142g 1 868626 870170 ON 8 H10142 (868626..870170) similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Protein of unknown function localized to the cytoplasm computational analysis of large-scale protein- protein interaction data suggests a possible role in transcriptional regulation SAKL0H10164g 0 870210 871172 ON 8 H10164 complement(870210..871172) similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase increases the intracellular pool of geranylgeranyl diphosphate suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic SAKL0H10186g 1 871320 871952 ON 8 H10186 (871320..871952) similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein required for the protein degradation process associated with the ER involved in the retrograde transport of misfolded or unassembled proteins SAKL0H10208g 0 871981 872904 ON 8 H10208 complement(871981..872904) some similarities with uniprot|Q02749 Saccharomyces cerevisiae YPL068C Hypothetical ORF SAKL0H10230g 0 873713 874345 ON 8 H10230 complement(873713..874345) similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Hypothetical ORF SAKL0H10252g 0 874639 876144 ON 8 H10252 complement(874639..876144) highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase that is activated by Mg2 and utilizes NADP as the preferred coenzyme SAKL0H10274g 0 877895 880549 ON 8 H10274 complement(877895..880549) weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine not related to the COS family of subtelomerically-encoded proteins SAKL0H10296g 0 880969 882405 ON 8 H10296 complement(880969..882405) similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Protein of the inner mitochondrial membrane required for import of mitochondrial matrix proteins SAKL0H10318g 1 882550 883551 ON 8 H10318 (882550..883551) some similarities with uniprot|Q02770 Saccharomyces cerevisiae YPL064C SAKL0H10340g 0 883790 886009 ON 8 H10340 complement(883790..886009) weakly similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C SAKL0H10362g 0 886301 887020 ON 8 H10362 complement(886301..887020) highly similar to uniprot|Q75A75 Ashbya gossypii ADR043W ADR043Wp and similar to YPL065W uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole SAKL0H10384g 0 887154 888522 ON 8 H10384 complement(887154..888386,888445..888522) similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Hypothetical ORF SAKL0H10406g 0 889728 892268 ON 8 H10406 complement(889728..892268) similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W CDC47 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase Sklu_YGOB_YBR201C-A 1 894364 894591 ON 8 YBR201C-A (894364..894591) ANNOTATED BY YGOB - SAKL0H10428g 0 896845 897225 ON 8 H10428 complement(896845..897225) no similarity SAKL0H10450g 0 897598 898776 ON 8 H10450 complement(897598..898776) similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C Hypothetical ORF SAKL0H10472g 1 899601 900689 ON 8 H10472 (899601..900689) weakly similar to uniprot|P53324 Saccharomyces cerevisiae YGR263C SAKL0H10494g 1 902190 903437 ON 8 H10494 (902190..903437) highly similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1 2- mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family SAKL0H10516g 1 903665 904843 ON 8 H10516 (903665..904843) highly similar to gnl|GLV|KLLA0F28017g Kluyveromyces lactis KLLA0F28017g and similar to YPL060W uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W LPE10 Mitochondrial inner membrane magnesium transporter involved in maintenance of magnesium concentrations inside mitochondria indirectly affects splicing of group II introns functionally and structurally related to Mrs2p SAKL0H10538g 1 905094 906374 ON 8 H10538 (905094..906374) similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis SAKL0H10560g 0 906483 911975 ON 8 H10560 complement(906483..911975) highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1 2 Urea amidolyase contains both urea carboxylase and allophanate hydrolase activities degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate an intermediate in allantoin degradation Sklu_8.trna13C 0 912781 912852 ON 8 tC-GCA complement(912781..912852) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 SAKL0H10626g 1 914158 914589 ON 8 H10626 (914158..914589) uniprot|Q6YFE4 Saccharomyces kluyveri Glutaredoxin SAKL0H10648g 0 916086 917738 ON 8 H10648 complement(916086..917738) similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W SAKL0H10670g 0 918091 922620 ON 8 H10670 complement(918091..922620) highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid- inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity Sklu_YGOB_Anc_8.516 0 923285 923473 ON 8 Anc_8.516 complement(923285..923473) ANNOTATED BY YGOB - Search-DOGS addition SAKL0H10692g 1 924316 925719 ON 8 H10692 (924316..925719) similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF Sklu_8.trna14S 1 927901 928008 ON 8 tS-AGA (927901..927937,927964..928008) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0H10736g 0 928636 929730 ON 8 H10736 complement(928636..929730) similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C and similar to uniprot|P38287 Saccharomyces cerevisiae YBR161w CSH1 SUR1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase forms a complex with probable regulatory subunit Csg2p SAKL0H10758g 0 930403 931302 ON 8 H10758 complement(930403..931302) highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates SAKL0H10780g 0 931987 933021 ON 8 H10780 complement(931987..933021) similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase SAKL0H10802g 0 933265 934142 ON 8 H10802 complement(933265..934054,934120..934142) some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function null mutant forms abnormally large cells SAKL0H10824g 0 934337 935881 ON 8 H10824 complement(934337..935881) similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability SAKL0H10846g 1 936812 938179 ON 8 H10846 (936812..938179) some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function SAKL0H10868g 1 939253 940062 ON 8 H10868 (939253..940062) no similarity SAKL0H10890g 0 940629 943046 ON 8 H10890 complement(940629..943046) similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes SAKL0H10912g 1 943288 945711 ON 8 H10912 (943288..945711) weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation. SAKL0H10934g 0 945834 946976 ON 8 H10934 complement(945834..946976) similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery SAKL0H10956g 0 947455 948789 ON 8 H10956 complement(947455..948789) similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation SAKL0H11000g 0 950276 951109 ON 8 H11000 complement(950276..951109) similar to uniprot|P53386 Saccharomyces cerevisiae YPR192W AQY1 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance Sklu_YGOB_H11022 1 951723 952509 ON 8 H11022 (951723..951896,951898..952509) ANNOTATED BY YGOB - SAKL0H11022g 1 951898 952509 OFF 8 H11022 (951898..952509) similar to gnl|GLV|CAGL0M07403g Candida glabrata CAGL0M07403g and weakly similar to YPL052W uniprot|Q02803 Saccharomyces cerevisiae YPL052W OAZ1 Regulator of ornithine decarboxylase (Spe1p) antizyme that binds to Spe1p to regulate ubiquitin-independent degradation ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine- regulated SAKL0H11044g 1 952882 953307 ON 8 H11044 (952882..953307) similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C SAKL0H11066g 1 955148 955741 ON 8 H11066 (955148..955741) highly similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP- ribosylation factor SAKL0H11088g 1 955980 957626 ON 8 H11088 (955980..957626) similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible alkaline phosphatase a glycoprotein localized to the vacuole regulated by levels of inorganic phosphate and by a system consisting of Pho4p Pho9p Pho80p Pho81p and Pho85p dephosphorylates phosphotyrosyl peptides SAKL0H11110g 0 957784 958965 ON 8 H11110 complement(957784..958965) highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p Mnn10p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation SAKL0H11132g 0 959229 960260 ON 8 H11132 complement(959229..960260) weakly similar to uniprot|Q03063 Saccharomyces cerevisiae YPL049C DIG1 Regulatory protein of unknown function constitutively-expressed involved in the regulation of mating-specific genes and the invasive growth pathway required for MAP-kinase imposed repression inhibits pheromone-responsive transcription SAKL0H11154g 1 960815 962071 ON 8 H11154 (960815..962071) similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Translational cofactor elongation factor-1 gamma participates in the regulation of GTP-binding protein EF-1 alpha may play a redundant role in the regulation of protein synthesis or another GTP-dependent process SAKL0H11176g 1 962915 964630 ON 8 H11176 (962915..964630) conserved hypothetical protein SAKL0H11198g 1 964858 966393 ON 8 H11198 (964858..966393) highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation SAKL0H11220g 1 966625 966921 ON 8 H11220 (966625..966921) similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes SAKL0H11242g 1 967169 968386 ON 8 H11242 (967169..968386) similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Cytosolic protein required for sporulation also required for the ubiquitination of the gluconeogenetic enzyme fructose-1 6-bisphosphatase which is degraded rapidly after the switch from gluconeogenesis to glycolysis SAKL0H11264g 0 968407 968700 ON 8 H11264 complement(968407..968700) similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C forms heterodimer with Ela1p that participates in transcription elongation expression dramatically upregulated during sporulation widely conserved among eukaryotes SAKL0H11286g 1 968823 971249 ON 8 H11286 (968823..971249) similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Vacuolar sorting protein SAKL0H11308g 0 971267 972592 ON 8 H11308 complement(971267..972592) similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein required for chromosome stability interacts with kinetochore proteins Ctf19p Ctf3p and Iml3p exhibits a two-hybrid interaction with Mif2p association with CEN DNA requires Ctf19p SAKL0H11330g 1 972836 974929 ON 8 H11330 (972836..974929) similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis contains four RNA recognition motifs (RRMs) SAKL0H11352g 0 975064 976857 ON 8 H11352 complement(975064..976857) similar to uniprot|P39073 Saccharomyces cerevisiae YPL042C SSN3 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation SAKL0H11374g 0 977074 977691 ON 8 H11374 complement(977074..977691) some similarities with uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Hypothetical ORF SAKL0H11396g 0 977817 980792 ON 8 H11396 complement(977817..980792) similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase null mutant is deficient in respiratory growth SAKL0H11418g 1 980990 981946 ON 8 H11418 (980990..981946) weakly similar to uniprot|Q03080 Saccharomyces cerevisiae YPL039W Hypothetical ORF SAKL0H11440g 1 982180 982797 ON 8 H11440 (982180..982797) similar to uniprot|Q12041 Saccharomyces cerevisiae YDR253C MET32 Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes SAKL0H11462g 0 982999 983475 ON 8 H11462 complement(982999..983475) highly similar to uniprot|Q02642 Saccharomyces cerevisiae YPL037C EGD1 Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting associated with cytoplasmic ribosomes enhances DNA binding of the Gal4p activator homolog of human BTF3b SAKL0H11484g 0 983765 985447 ON 8 H11484 complement(983765..985447) similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway responsible for uptake of 7-keto 8-aminopelargonic acid BIO5 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis SAKL0H11506g 0 985709 986410 ON 8 H11506 complement(985709..986410) similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels SAKL0H11528g 1 986728 988203 ON 8 H11528 (986728..988203) similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis Sklu_8.trna15I 1 989119 989192 ON 8 tI-AAU (989119..989192) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0H11594g 0 989608 992292 ON 8 H11594 complement(989608..992292) similar to uniprot|Q03088 Saccharomyces cerevisiae YPL032C SVL3 Protein of unknown function mutant phenotype suggests a potential role in vacuolar function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck SAKL0H11616g 1 992829 993929 ON 8 H11616 (992829..993929) similar to gnl|GLV|KLLA0D11968g Kluyveromyces lactis KLLA0D11968g and weakly similar to YDR249C uniprot|Q03787 Saccharomyces cerevisiae YDR249C Hypothetical ORF SAKL0H11638g 0 994049 995032 ON 8 H11638 complement(994049..994946,995016..995032) highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase with ten cyclin partners involved in environmental stress response in phosphate-rich conditions Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 SAKL0H11660g 1 995184 996791 ON 8 H11660 (995184..996791) similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W Hypothetical ORF SAKL0H11682g 1 996881 999202 ON 8 H11682 (996881..999202) similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase component of the mitochondrial degradosome SAKL0H11704g 1 999931 1001130 ON 8 H11704 (999931..1001130) highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis SAKL0H11726g 1 1001401 1001958 ON 8 H11726 (1001401..1001958) similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Hypothetical ORF SAKL0H11748g 0 1002207 1003541 ON 8 H11748 complement(1002207..1003541) similar to uniprot|Q12505 Saccharomyces cerevisiae YPL026C SKS1 multicopy suppressor of snf3 and grr1 mutants serine/threonine protein kinase homologous to Ran1p SAKL0H11770g 0 1004615 1005880 ON 8 H11770 complement(1004615..1005880) conserved hypothetical protein SAKL0H11792g 0 1006556 1007128 ON 8 H11792 complement(1006556..1007128) similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic SAKL0H11814g 1 1007321 1008025 ON 8 H11814 (1007321..1008025) similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Protein of unknown function GFP tagged protein localizes to the cytoplasm and nucleus SAKL0H11836g 0 1008129 1010063 ON 8 H11836 complement(1008129..1010063) similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10- methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway SAKL0H11858g 1 1010684 1013758 ON 8 H11858 (1010684..1013758) similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease SAKL0H11880g 0 1013934 1017563 ON 8 H11880 complement(1013934..1017563) some similarities with uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Global transcription activator that acts in complex with Snf2p Snf5p Snf6p and Swi3p to assist gene-specific activators involved in the regulation of expression of many genes including ADH1 ADH2 GAL1 HO INO1 and SUC2 Zinc-finger transcription factor SAKL0H11902g 1 1018143 1018424 ON 8 H11902 (1018143..1018424) no similarity SAKL0H11924g 0 1018983 1020098 ON 8 H11924 complement(1018983..1020098) similar to uniprot|P50108 Saccharomyces cerevisiae YDR245W MNN10 Subunit of a Golgi mannosyltransferase complex also containing Anp1p Mnn9p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone membrane protein of the mannosyltransferase family SAKL0H11946g 0 1020512 1022233 ON 8 H11946 complement(1020512..1022233) similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL- like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR) SAKL0H11968g 1 1022452 1024152 ON 8 H11968 (1022452..1024152) similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site SAKL0H11990g 0 1024579 1026219 ON 8 H11990 complement(1024579..1026219) similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase SAKL0H12012g 0 1027110 1028144 ON 8 H12012 complement(1027110..1028144) similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C Sklu_8.trna16Y 0 1028261 1028360 ON 8 tY-GUA complement(1028261..1028296,1028322..1028360) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.79 SAKL0H12056g 1 1029088 1029537 ON 8 H12056 (1029088..1029537) similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing SAKL0H12078g 1 1029936 1031369 ON 8 H12078 (1029936..1031369) weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP SAKL0H12100g 1 1031875 1034241 ON 8 H12100 (1031875..1034241) weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF SAKL0H12122g 1 1034683 1037610 ON 8 H12122 (1034683..1037610) highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer SAKL0H12144g 0 1037828 1038697 ON 8 H12144 complement(1037828..1038697) highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit SAKL0H12166g 1 1038921 1040522 ON 8 H12166 (1038921..1040522) some similarities with uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal SAKL0H12188g 1 1040730 1041287 ON 8 H12188 (1040730..1041287) similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane SAKL0H12210g 0 1041338 1042210 ON 8 H12210 complement(1041338..1042210) similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF SAKL0H12254g 1 1043145 1045187 ON 8 H12254 (1043145..1045187) similar to uniprot|Q12424 Saccharomyces cerevisiae YDL206W Hypothetical ORF SAKL0H12276g 0 1045202 1046830 ON 8 H12276 complement(1045202..1046830) similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats SAKL0H12298g 0 1047379 1048374 ON 8 H12298 complement(1047379..1048374) highly similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p SAKL0H12320g 0 1048942 1051008 ON 8 H12320 complement(1048942..1051008) highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway SAKL0H12342g 1 1052455 1053306 ON 8 H12342 (1052455..1053306) similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon- like A) subfamily SAKL0H12364g 0 1053913 1055577 ON 8 H12364 complement(1053913..1055577) highly similar to gnl|GLV|KLLA0C15059g Kluyveromyces lactis KLLA0C15059g and similar to YDR232W uniprot|P09950 Saccharomyces cerevisiae YDR232W HEM1 5- aminolevulinate synthase catalyzes the first step in the heme biosynthetic pathway an N-terminal signal sequence is required for localization to the mitochondrial matrix expression is regulated by Hap2p-Hap3p SAKL0H12386g 0 1055800 1057605 ON 8 H12386 complement(1055800..1057605) similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF SAKL0H12408g 1 1058215 1058784 ON 8 H12408 (1058215..1058784) highly similar to gnl|GLV|KLLA0C15015g Kluyveromyces lactis KLLA0C15015g and similar to YDR231C uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase SAKL0H12430g 1 1059187 1060434 ON 8 H12430 (1059187..1060434) conserved hypothetical protein SAKL0H12452g 0 1060967 1062334 ON 8 H12452 complement(1060967..1062334) similar to uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase SAKL0H12474g 1 1062548 1063237 ON 8 H12474 (1062548..1063237) similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit SAKL0H12496g 1 1063437 1064282 ON 8 H12496 (1063437..1064282) highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA SAKL0H12518g 0 1064480 1066672 ON 8 H12518 complement(1064480..1066672) similar to uniprot|Q12407 Saccharomyces cerevisiae YDL199C Hypothetical ORF SAKL0H12540g 0 1066978 1068693 ON 8 H12540 complement(1066978..1068693) some similarities with uniprot|Q07807 Saccharomyces cerevisiae YLL013c transcript-specific regulator of mRNA degradation SAKL0H12562g 0 1069635 1070531 ON 8 H12562 complement(1069635..1070531) highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family (putative) mitochondrial carrier protein SAKL0H12584g 1 1071082 1072812 ON 8 H12584 (1071082..1072812) similar to uniprot|Q74ZL0 Ashbya gossypii AGR190C AGR190Cp and some similarites with YDR228C uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor essential component of cleavage and polyadenylation factor IA (CF IA) involved in pre-mRNA 3' end processing and in transcription termination binds C- terminal domain of largest subunit of RNA pol II (Rpo21p) SAKL0H12606g 0 1074093 1079063 ON 8 H12606 complement(1074093..1079063) some similarities with uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex required for Cdc7p kinase activity and initiation of DNA replication phosphorylates the Mcm2-7 family of proteins cell cycle regulated SAKL0H12628g 0 1079678 1080364 ON 8 H12628 complement(1079678..1080364) highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 adenylate kinase SAKL0H12650g 1 1082785 1084836 ON 8 H12650 (1082785..1084836) weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids potential Cdc28p substrate SAKL0H12672g 0 1084978 1085373 ON 8 H12672 complement(1084978..1085373) similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p SAKL0H12694g 1 1086022 1086420 ON 8 H12694 (1086022..1086420) highly similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation SAKL0H12716g 1 1087468 1088355 ON 8 H12716 (1087468..1088355) highly similar to uniprot|Q74ZL6 Ashbya gossypii AGR182C AGR182Cp and similar to YLR220W uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Functions in the homeostasis of both calcium and manganese ions Possible transmembrane Ca2 transporter SAKL0H12738g 0 1088456 1089037 ON 8 H12738 complement(1088456..1089037) some similarities with uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation required for accumulation of wild- type levels of large (60S) ribosomal subunits binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus SAKL0H12760g 0 1089272 1091797 ON 8 H12760 complement(1089272..1091797) highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA SAKL0H12782g 0 1093542 1096457 ON 8 H12782 complement(1093542..1096457) similar to gnl|GLV|KLLA0F13222g Kluyveromyces lactis KLLA0F13222g and weakly similar to YLR223C uniprot|P39520 Saccharomyces cerevisiae YLR223C IFH1 Essential protein with a highly acidic N-terminal domain IFH1 exhibits genetic interactions with FHL1 overexpression interferes with silencing at telomeres and HM loci potential Cdc28p substrate SAKL0H12804g 0 1096888 1098096 ON 8 H12804 complement(1096888..1098096) similar to uniprot|Q04925 Saccharomyces cerevisiae YDR222W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0H12826g 0 1098607 1100694 ON 8 H12826 complement(1098607..1100694) similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W Hypothetical ORF SAKL0H12848g 1 1101137 1102564 ON 8 H12848 (1101137..1102564) weakly similar to uniprot|Q04922 Saccharomyces cerevisiae YDR219C Hypothetical ORF SAKL0H12870g 1 1102857 1104011 ON 8 H12870 (1102857..1104011) similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II SAKL0H12892g 1 1104296 1105690 ON 8 H12892 (1104296..1105690) similar to uniprot|Q04921 Saccharomyces cerevisiae YDR218C SPR28 Septin-related protein expressed during sporulation SAKL0H12914g 0 1105759 1107069 ON 8 H12914 complement(1105759..1107069) weakly similar to uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Component of the meiotic outer plaque a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane SAKL0H12936g 1 1107451 1111404 ON 8 H12936 (1107451..1111404) weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein required for cell-cycle arrest in G1/S intra-S and G2/M transmits checkpoint signal by activating Rad53p and Chk1p hyperphosphorylated by Mec1p and Tel1p potential Cdc28p substrate SAKL0H12958g 0 1112324 1115713 ON 8 H12958 complement(1112324..1115713) similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization SAKL0H12980g 1 1116396 1118045 ON 8 H12980 (1116396..1118045) similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF SAKL0H13002g 0 1118393 1119448 ON 8 H13002 complement(1118393..1119448) similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase SAKL0H13024g 0 1119585 1121849 ON 8 H13024 complement(1119585..1121849) similar to gnl|GLV|KLLA0A04169g Kluyveromyces lactis KLLA0A04169g and some similarites with YDR213W uniprot|Q12151 Saccharomyces cerevisiae YDR213W UPC2 involved in sterol uptake zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type SAKL0H13046g 0 1122401 1124083 ON 8 H13046 complement(1122401..1124083) highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 tailless complex polypeptide 1 chaperonin subunit alpha SAKL0H13068g 0 1125095 1125670 ON 8 H13068 complement(1125095..1125670) highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase essential for establishment and maintenance of cell polarity mutants have defects in the organization of actin and septins SAKL0H13090g 0 1125883 1128066 ON 8 H13090 complement(1125883..1128066) similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression Sklu_8.trna17I 0 1128226 1128395 ON 8 tI-UAU complement(1128226..1128261,1128359..1128395) tRNA Type: Ile (I) | Anti-Codon: UAU | Cove Score: 55.03 SAKL0H13178g 1 1129590 1130117 ON 8 H13178 (1129590..1130117) no similarity SAKL0H13200g 0 1130245 1132242 ON 8 H13200 complement(1130245..1132242) similar to uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol-4-phosphate 5-kinase involved in actin cytoskeleton organization and cell morphogenesis multicopy suppressor of stt4 mutation SAKL0H13222g 1 1133353 1136652 ON 8 H13222 (1133353..1136652) highly similar to gnl|GLV|KLLA0F20658g Kluyveromyces lactis KLLA0F20658g and similar to YDR039C uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P- type ATPase sodium pump involved in Na efflux to allow salt tolerance likely not involved in Li efflux SAKL0H13244g 0 1136877 1138271 ON 8 H13244 complement(1136877..1138271) similar to uniprot|Q05979 Saccharomyces cerevisiae YLR231C BNA5 Kynureninase required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway SAKL0H13266g 1 1138536 1140362 ON 8 H13266 (1138536..1140362) some similarities with uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription Ume6p is a C6 zinc finger URS1-binding protein. SAKL0H13288g 0 1140503 1143157 ON 8 H13288 complement(1140503..1143157) weakly similar to uniprot|Q03466 Saccharomyces cerevisiae YDR206W SAKL0H13310g 1 1143437 1145353 ON 8 H13310 (1143437..1145353) similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III SAKL0H13332g 0 1145383 1147419 ON 8 H13332 complement(1145383..1147419) weakly similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family localizes to the endoplasmic reticulum and nucleus mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids SAKL0H13354g 1 1147980 1149713 ON 8 H13354 (1147980..1149713) similar to uniprot|Q05998 YLR237W Saccharomyces cerevisiae THI7 Plasma membrane transporter responsible for the uptake of thiamine SAKL0H13376g 0 1150090 1151079 ON 8 H13376 complement(1150090..1151079) highly similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis possibly functioning in stabilization of Coq7p located on the matrix face of the mitochondrial inner membrane SAKL0H13398g 1 1151202 1152224 ON 8 H13398 (1151202..1152224) similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p Rav2p Skp1p) a complex that associates with the V1 domain of the vacuolar membrane (H )-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme SAKL0H13420g 0 1152216 1152689 ON 8 H13420 complement(1152216..1152689) similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle SAKL0H13442g 1 1153418 1154812 ON 8 H13442 (1153418..1154812) similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C VPS64 SAKL0H13464g 0 1154899 1155855 ON 8 H13464 complement(1154899..1155855) similar to uniprot|Q06005 Saccharomyces cerevisiae YLR239C LIP2 Lipoyl ligase involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups SAKL0H13486g 1 1156000 1157376 ON 8 H13486 (1156000..1157376) similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C Hypothetical ORF SAKL0H13508g 0 1157406 1158524 ON 8 H13508 complement(1157406..1158524) similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Translational activator of COB mRNA soluble protein cytochrome b translational activator SAKL0H13530g 1 1158681 1159412 ON 8 H13530 (1158681..1159412) similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C predicted to catalyze the final step in synthesis of Coenzyme A SAKL0H13552g 0 1159498 1160910 ON 8 H13552 complement(1159498..1160910) similar to uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation also involved in snoRNA maturation SAKL0H13574g 1 1161196 1163202 ON 8 H13574 (1161196..1163202) similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns presumed RNA helicase due to DEAD-box motif SAKL0H13596g 1 1163807 1166422 ON 8 H13596 (1163807..1166422) highly similar to uniprot|Q750Q5 Ashbya gossypii AGL113C AGL113Cp and similar to YLR240W uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3- phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase SAKL0H13618g 1 1166638 1168983 ON 8 H13618 (1166638..1168983) similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Hypothetical ORF SAKL0H13640g 0 1169052 1169960 ON 8 H13640 complement(1169052..1169960) similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C SAKL0H13662g 1 1170103 1171779 ON 8 H13662 (1170103..1171779) weakly similar to uniprot|P49686 Saccharomyces cerevisiae YDR192C NUP42 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p SAKL0H13684g 1 1171966 1172781 ON 8 H13684 (1171966..1172781) highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Protein required for cell viability SAKL0H13706g 0 1172868 1174016 ON 8 H13706 complement(1172868..1174016) similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst3p in silencing at telomeres cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism SAKL0H13728g 1 1174638 1176023 ON 8 H13728 (1174638..1176023) highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 RUVB-like protein TIP49a Homologue RUVB-like protein SAKL0H13750g 0 1176153 1178151 ON 8 H13750 complement(1176153..1178047,1178109..1178151) similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p SAKL0H13772g 0 1178377 1180008 ON 8 H13772 complement(1178377..1180008) highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p essential protein that is required for the assembly of actin and tubulins in vivo contains an ATP-binding motif SAKL0H13794g 0 1180289 1181410 ON 8 H13794 complement(1180289..1181410) highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map2p SAKL0H13816g 0 1181645 1182199 ON 8 H13816 complement(1181645..1182199) similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified localizes to both the nucleus and cytoplasm SAKL0H13838g 1 1182927 1185158 ON 8 H13838 (1182927..1185158) similar to gnl|GLV|KLLA0D18392g Kluyveromyces lactis KLLA0D18392g and weakly similar to YDR186C uniprot|Q04007 Saccharomyces cerevisiae YDR186C Hypothetical ORF SAKL0H13860g 1 1185970 1187028 ON 8 H13860 (1185970..1187028) similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase composed of Erf2p and Shr5p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage mutants partially mislocalize Ras2p to the vacuole SAKL0H13882g 0 1187379 1188080 ON 8 H13882 complement(1187379..1188080) highly similar to uniprot|P35200 Saccharomyces cerevisiae YLR168C possibly involved in intramitochondrial sorting SAKL0H13904g 1 1188453 1189304 ON 8 H13904 (1188453..1189304) similar to uniprot|Q6Q540 Saccharomyces cerevisiae YDR184C ATC1 Nuclear protein possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern SAKL0H13926g 0 1189515 1189979 ON 8 H13926 complement(1189515..1189979) similar to uniprot|P61864 Saccharomyces cerevisiae YLR167W RPS31 and similar to uniprot|P04838 Saccharomyces cerevisiae YIL148W and similar to uniprot|P04838 Saccharomyces cerevisiae YKR094C and similar to uniprot|P04838 Saccharomyces cerevisiae YLL039C Fusion proteins that are cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin SAKL0H13948g 0 1190322 1191008 ON 8 H13948 complement(1190322..1191008) similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W SAKL0H13970g 1 1191579 1194056 ON 8 H13970 (1191579..1194056) similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis SAKL0H13992g 0 1194120 1195580 ON 8 H13992 complement(1194120..1195580) similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis mutants display actin and general growth defects heterogeneous cell cycle arrests and pleiotropic defects in cell cycle progression and organelle distribution SAKL0H14014g 0 1196584 1198659 ON 8 H14014 complement(1196584..1198659) conserved hypothetical protein SAKL0H14036g 1 1200951 1202117 ON 8 H14036 (1200951..1202117) weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181c SAS4 SAKL0H14058g 0 1202934 1207364 ON 8 H14058 complement(1202934..1207364) similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Sister chromatid cohesion protein SAKL0H14080g 1 1207599 1208363 ON 8 H14080 (1207599..1208363) similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5 SAKL0H14102g 0 1208344 1209660 ON 8 H14102 complement(1208344..1209660) similar to uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Hypothetical ORF SAKL0H14124g 1 1209780 1210274 ON 8 H14124 (1209780..1210274) similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin- like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling SAKL0H14146g 0 1210361 1210861 ON 8 H14146 complement(1210361..1210861) similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone SAKL0H14168g 1 1211470 1212855 ON 8 H14168 (1211470..1212855) highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins SAKL0H14190g 0 1213167 1215101 ON 8 H14190 complement(1213167..1215101) similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes component of transcriptional adaptor and histone acetyltransferase complexes the ADA complex the SAGA complex and the SLIK complex SAKL0H14212g 1 1215345 1216250 ON 8 H14212 (1215345..1216250) similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit SAKL0H14234g 0 1216484 1217300 ON 8 H14234 complement(1216484..1217191,1217259..1217300) similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance rDNA- binding component of the Pol I transcription system associates with a 5'-3' DNA helicase and Fpr1p a prolyl isomerase SAKL0H14244r 1 1223406 1225203 ON 8 H14244r (1223406..1225203) RDN18-1 18S rRNA SAKL0H14248r 1 1225430 1225587 ON 8 H14248r (1225430..1225587) RDN58-1 5.8S rRNA SAKL0H14252r 1 1225798 1229185 ON 8 H14252r (1225798..1229185) RDN25-1 25S rRNA SAKL0H14260r 0 1230278 1230398 ON 8 H14260r complement(1230278..1230398) RDN5-1 5S rRNA SAKL0H14264r 1 1232062 1233859 OFF 8 H14264r (1232062..1233859) RDN18-1 18S rRNA SAKL0H14268r 1 1234086 1234243 OFF 8 H14268r (1234086..1234243) RDN58-1 5.8S rRNA SAKL0H14272r 1 1234454 1237841 OFF 8 H14272r (1234454..1237841) RDN25-1 25S rRNA SAKL0H14295r 0 1241554 1241674 OFF 8 H14295r complement(1241554..1241674) RDN5-1 5S rRNA SAKL0H14366g 1 1243365 1245875 ON 8 H14366 (1243365..1245875) no similarity SAKL0H14388g 1 1247106 1248248 ON 8 H14388 (1247106..1248248) similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low-zinc conditions by the Zap1p transcription factor SAKL0H14410g 1 1249412 1250452 ON 8 H14410 (1249412..1250452) similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Protein involved in regulation of arginine- responsive and Mcm1p-dependent genes has a dual- specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen- responsive genes SAKL0H14432g 0 1250592 1252685 ON 8 H14432 complement(1250592..1252685) similar to uniprot|P05453 Saccharomyces cerevisiae YDR172W SUP35 Translation termination factor eRF3 altered protein conformation creates the [PSI( )] prion a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype SAKL0H14454g 0 1252942 1254078 ON 8 H14454 complement(1252942..1254078) similar to uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins oligomer dissociation is not required for function involved in cytoskeleton reorganization after heat shock Sklu_8.trna18Q 1 1254308 1254379 ON 8 tQ-UUG (1254308..1254379) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 65.94 SAKL0H14498g 0 1254660 1255994 ON 8 H14498 complement(1254660..1255994) uniprot|Q6YFE5 Saccharomyces kluyveri GTP cyclohydrolase SAKL0H14520g 1 1256509 1262025 ON 8 H14520 (1256509..1262025) similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi intra-Golgi transport and ER-to-Golgi transport found in the cytoplasm and on Golgi-associated coated vesicles SAKL0H14542g 1 1262716 1264767 ON 8 H14542 (1262716..1264767) highly similar to uniprot|P52910 Saccharomyces cerevisiae YLR153C ACS2 Acetyl-coA synthetase isoform required for growth on glucose expressed under anaerobic conditions SAKL0H14564g 1 1265769 1267679 ON 8 H14564 (1265769..1267679) similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Hypothetical ORF SAKL0H14586g 1 1268068 1269042 ON 8 H14586 (1268068..1269042) similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids SAKL0H14608g 0 1269187 1270103 ON 8 H14608 complement(1269187..1269957,1270098..1270103) similar to uniprot|P39015 Saccharomyces cerevisiae YLR150W STM1 Protein that binds quadruplex nucleic acids; multicopy suppressor of tom1 and pop2 mutations; acts with Cdc13p to maintain telomere structure SAKL0H14630g 1 1270556 1272106 ON 8 H14630 (1270556..1272106) weakly similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Protein that binds Sin3p in a two- hybrid assay SAKL0H14652g 1 1272436 1274526 ON 8 H14652 (1272436..1274526) weakly similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Hypothetical ORF SAKL0H14674g 0 1274788 1276284 ON 8 H14674 complement(1274788..1276284) similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle SAKL0H14696g 0 1276434 1277045 ON 8 H14696 complement(1276434..1277045) similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification SAKL0H14718g 0 1277222 1279948 ON 8 H14718 complement(1277222..1279948) similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins required for vacuolar biogenesis forms complex with Pep5p that mediates protein transport to the vacuole SAKL0H14740g 1 1280104 1280412 ON 8 H14740 (1280104..1280412) highly similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein SAKL0H14762g 1 1280740 1283439 ON 8 H14762 (1280740..1283439) similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis SAKL0H14784g 0 1283478 1283801 ON 8 H14784 complement(1283478..1283801) conserved hypothetical protein SAKL0H14806g 0 1284426 1285760 ON 8 H14806 complement(1284426..1285760) similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7- methylguanosine modification of tRNA SAKL0H14828g 1 1286201 1287097 ON 8 H14828 (1286201..1287097) similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine Synthase SAKL0H14850g 0 1287217 1287915 ON 8 H14850 complement(1287217..1287915) similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Protein required for cell viability component of RNase MRP which is involved in RNA processing in mitochondria SAKL0H14872g 1 1288862 1291171 ON 8 H14872 (1288862..1291171) similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1 3-endoglucanase expression is induced during sporulation may have a role in cortical actin cytoskeleton assembly SAKL0H14894g 1 1291462 1293633 ON 8 H14894 (1291462..1293633) similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function SAKL0H14916g 0 1293760 1294893 ON 8 H14916 complement(1293760..1294893) conserved hypothetical protein SAKL0H14938g 0 1295178 1297253 ON 8 H14938 complement(1295178..1297253) similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Hypothetical ORF SAKL0H14960g 0 1297640 1299043 ON 8 H14960 complement(1297640..1299043) similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 proline oxidase SAKL0H14982g 0 1299373 1300935 ON 8 H14982 complement(1299373..1300935) weakly similar to uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Transcription factor member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p involved in transcription of rDNA by RNA polymerase I SAKL0H15004g 1 1301111 1303210 ON 8 H15004 (1301111..1303210) similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV coordinates expression of mitochondrially-encoded genes may facilitate delivery of mRNA to membrane-bound translation machinery SAKL0H15026g 0 1303250 1303882 ON 8 H15026 complement(1303250..1303882) similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W SAKL0H15048g 1 1304135 1304758 ON 8 H15048 (1304135..1304758) some similarities with uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex found in the nucleus and cytoplasm contains an SH3 domain that binds Pbs2p SAKL0H15070g 0 1304900 1306042 ON 8 H15070 complement(1304900..1306042) similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W interacts with PP2C SAKL0H15092g 0 1306212 1308764 ON 8 H15092 complement(1306212..1308764) similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes SAKL0H15114g 0 1308968 1311622 ON 8 H15114 complement(1308968..1311622) similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W SAKL0H15136g 0 1312258 1316298 ON 8 H15136 complement(1312258..1316298) similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus SAKL0H15158g 0 1316402 1317388 ON 8 H15158 complement(1316402..1317388) similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W Hypothetical ORF SAKL0H15180g 0 1317500 1318597 ON 8 H15180 complement(1317500..1318597) highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis SAKL0H15202g 0 1318830 1319387 ON 8 H15202 complement(1318830..1319387) similar to uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14 Sklu_8.trna19D 0 1319686 1319757 ON 8 tD-GUC complement(1319686..1319757) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0H15268g 1 1321270 1321758 ON 8 H15268 (1321270..1321758) highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A SAKL0H15290g 1 1322030 1323211 ON 8 H15290 (1322030..1323211) similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p clathrin adaptor complex AP-1 and clathrin SAKL0H15312g 0 1323294 1324085 ON 8 H15312 complement(1323294..1324085) similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 RWD domain containing protein of unknown function SAKL0H15334g 1 1324614 1325471 ON 8 H15334 (1324614..1325471) similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C SAKL0H15356g 0 1326331 1328661 ON 8 H15356 complement(1326331..1328661) similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C SAKL0H15378g 0 1328983 1340172 ON 8 H15378 complement(1328983..1340172) similar to uniprot|Q750B4 Ashbya gossypii AGR043W AGR043Wp and weakly similar to YDR150W uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration localizes to the mother cell cortex and the bud tip may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex SAKL0H15400g 0 1340392 1342512 ON 8 H15400 complement(1340392..1342512) weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Subunit of a complex with Slx1p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p SAKL0H15422g 1 1342794 1344092 ON 8 H15422 (1342794..1344092) similar to uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha- ketoglutarate to succinyl-CoA SAKL0H15444g 0 1344329 1345957 ON 8 H15444 complement(1344329..1345957) similar to uniprot|P20485 Saccharomyces cerevisiae YLR133W CKI1 choline kinase SAKL0H15466g 1 1346173 1347063 ON 8 H15466 (1346173..1347063) weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Protein required for cell viability SAKL0H15488g 1 1347432 1349828 ON 8 H15488 (1347432..1349828) similar to uniprot|P21192 Saccharomyces cerevisiae YLR131C ACE2 Transcription factor that activates expression of early G1-specific genes localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters localization is regulated by phosphorylation potential Cdc28p substrate SAKL0H15510g 1 1350297 1351496 ON 8 H15510 (1350297..1351496) similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low-zinc conditions by the Zap1p transcription factor SAKL0H15532g 0 1351712 1354537 ON 8 H15532 complement(1351712..1354537) highly similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein specifically associated with the U3 snoRNA part of the large ribonucleoprotein complex known as the small subunit (SSU) processome required for 18S rRNA biogenesis part of the active pre-rRNA processing complex SAKL0H15554g 0 1354739 1356349 ON 8 H15554 complement(1354739..1356349) some similarities with uniprot|Q03761 Saccharomyces cerevisiae YDR145W SAKL0H15576g 0 1356651 1357499 ON 8 H15576 complement(1356651..1357499) similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Hypothetical ORF SAKL0H15598g 1 1357656 1360019 ON 8 H15598 (1357656..1360019) similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C SAKL0H15620g 1 1360992 1361762 ON 8 H15620 (1360992..1361762) similar to uniprot|Q12288 Saccharomyces cerevisiae YLR126C Hypothetical ORF SAKL0H15642g 0 1362186 1362902 ON 8 H15642 complement(1362186..1362902) no similarity SAKL0H15664g 1 1365886 1367556 ON 8 H15664 (1365886..1367556) similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. SAKL0H15686g 1 1367935 1369827 ON 8 H15686 (1367935..1367948,1368042..1369827) some similarities with uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing SAKL0H15708g 1 1370148 1371254 ON 8 H15708 (1370148..1371254) highly similar to uniprot|Q750X9 Ashbya gossypii AGL190W AGL190Wp and similar to YDR142C uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) Member of beta-transducin-related (WD- 40) protein family SAKL0H15730g 0 1371319 1371861 ON 8 H15730 complement(1371319..1371861) similar to gnl|GLV|KLLA0E04004g Kluyveromyces lactis KLLA0E04004g and weakly similar to YLR119W uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex which is involved in ubiquitin- dependent sorting of proteins into the endosome suppressor of rna1-1 mutation may be involved in RNA export from nucleus SAKL0H15752g 1 1372179 1372865 ON 8 H15752 (1372179..1372865) similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C SAKL0H15774g 1 1373091 1378241 ON 8 H15774 (1373091..1378241) similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1 SAKL0H15796g 0 1378228 1378911 ON 8 H15796 complement(1378228..1378911) similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family methylates release factor eRF1 (Sup45p) in vitro SAKL0H15818g 1 1379077 1379381 ON 8 H15818 (1379077..1379225,1379297..1379381) similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8 SAKL0H15840g 1 1379751 1381820 ON 8 H15840 (1379751..1381820) similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 SYnthetic lethal with cdcForty Crooked neck Like Factor an ortholog of the Drosophila crooked neck gene crn pre-mRNA splicing factor SAKL0H15862g 0 1381872 1383446 ON 8 H15862 complement(1381872..1383446) similar to uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex which defines the first step in the splicing pathway essential protein that interacts with Mud2p and Prp40p forming a bridge between the intron ends also involved in nuclear retention of pre-mRNA SAKL0H15884g 0 1383626 1386040 ON 8 H15884 complement(1383626..1386040) similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W SAKL0H15906g 1 1386394 1388613 ON 8 H15906 (1386394..1388613) conserved hypothetical protein SAKL0H15928g 0 1388807 1391167 ON 8 H15928 complement(1388807..1391167) weakly similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W SAKL0H15950g 1 1391391 1393295 ON 8 H15950 (1391391..1393295) similar to uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 PHO85 Requiring SAKL0H15972g 0 1393391 1395190 ON 8 H15972 complement(1393391..1395190) similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Sklu_8.trna20R 0 1395322 1395415 ON 8 tR-ACG complement(1395322..1395357,1395379..1395415) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 64.63 SAKL0H16016g 1 1396707 1401206 ON 8 H16016 (1396707..1401206) similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C SAKL0H16038g 0 1401627 1402931 ON 8 H16038 complement(1401627..1402931) highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters localization regulated by Ptp2p and Ptp3p SAKL0H16060g 1 1404382 1404765 ON 8 H16060 (1404382..1404765) some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C CCW12 Cell wall protein mutants are defective in mating and agglutination expression is downregulated by alpha-factor SAKL0H16082g 0 1405895 1406413 ON 8 H16082 complement(1405895..1406413) similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin reduces hydroperoxides to protect against oxidative damage function in vivo requires covalent conjugation to Urm1p SAKL0H16104g 1 1407312 1408802 ON 8 H16104 (1407312..1408802) similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C Hypothetical ORF SAKL0H16148g 1 1409423 1411015 ON 8 H16148 (1409423..1411015) similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C Hypothetical ORF SAKL0H16170g 1 1411076 1412002 ON 8 H16170 (1411076..1412002) similar to uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Basic protein with putative coiled-coil regions that comprises a filament between spindle pole bodies self-assembles into filaments with a diameter of approximately 10 nm potential Cdc28p substrate SAKL0H16192g 0 1412029 1413213 ON 8 H16192 complement(1412029..1413213) similar to uniprot|Q7LI70 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease required for maturation of the RNA component of RNase MRP functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases SAKL0H16214g 1 1413429 1428200 ON 8 H16214 (1413429..1428200) similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin) forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p) may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm SAKL0H16258g 1 1428968 1430032 ON 8 H16258 (1428968..1430032) similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C SAKL0H16280g 0 1430078 1430470 ON 8 H16280 complement(1430078..1430470) similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W Hypothetical ORF SAKL0H16302g 1 1430654 1432552 ON 8 H16302 (1430654..1432552) highly similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor SAKL0H16324g 1 1433315 1434190 ON 8 H16324 (1433315..1434190) weakly similar to uniprot|Q12107 Saccharomyces cerevisiae YLR102C APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition SAKL0H16346g 1 1434415 1436419 ON 8 H16346 (1434415..1434435,1434509..1436419) highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton SAKL0H16368g 0 1436646 1437745 ON 8 H16368 complement(1436646..1437645,1437705..1437745) highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs SAKL0H16390g 0 1437966 1441388 ON 8 H16390 complement(1437966..1441388) similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W Hypothetical ORF SAKL0H16412g 0 1441617 1446371 ON 8 H16412 complement(1441617..1446371) highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein catalyzes steps 2 through 6 in the biosynthesis of chorismate which is a precursor to aromatic amino acids SAKL0H16434g 0 1447419 1449086 ON 8 H16434 complement(1447419..1449086) similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Spore Wall Formation SAKL0H16456g 1 1449790 1450293 ON 8 H16456 (1449790..1450293) conserved hypothetical protein SAKL0H16478g 0 1450328 1450654 ON 8 H16478 complement(1450328..1450654) some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. SAKL0H16500g 1 1450828 1452087 ON 8 H16500 (1450828..1452087) similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C SAKL0H16522g 0 1452583 1453887 ON 8 H16522 complement(1452583..1453887) weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine SAKL0H16544g 1 1454826 1456692 ON 8 H16544 (1454826..1454875,1454943..1456692) similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal- type binuclear cluster domain DNA-binding transcriptional activator or CHA1 and some similarities to YOR337W uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator SAKL0H16566g 0 1457508 1458605 ON 8 H16566 complement(1457508..1458605) weakly similar to uniprot|Q04608 Saccharomyces cerevisiae YDR124W Hypothetical ORF SAKL0H16588g 1 1458924 1459976 ON 8 H16588 (1458924..1459976) similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative nuclear ubiquitin ligase based on computational analysis of large-scale protein-protein interaction data SAKL0H16610g 1 1460234 1461181 ON 8 H16610 (1460234..1461181) weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs) required for derepression of phospholipid biosynthetic genes in response to inositol depletion SAKL0H16632g 0 1461613 1464801 ON 8 H16632 complement(1461613..1464801) similar to uniprot|P13186 Saccharomyces cerevisiae YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p and to YDR122W uniprot|P13185 Saccharomyces cerevisiae YDR122W KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p SAKL0H16654g 1 1465099 1467213 ON 8 H16654 (1465099..1467213) similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p SAKL0H16676g 1 1467986 1469641 ON 8 H16676 (1467986..1469641) similar to gnl|GLV|KLLA0F19492g Kluyveromyces lactis KLLA0F19492g and weakly similar to YLR094C uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function SAKL0H16698g 1 1470300 1471808 ON 8 H16698 (1470300..1471808) similar to uniprot|Q750A2 Ashbya gossypii AGR055C AGR055Cp and weakly similar with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins SAKL0H16720g 1 1472129 1472880 ON 8 H16720 (1472129..1472144,1472210..1472880) similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion inhibits ATP-dependent Ca(2 ) transport activity of Pmc1p in the vacuolar membrane SAKL0H16742g 0 1472912 1473655 ON 8 H16742 complement(1472912..1473655) similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex involved in both chromosomal DNA replication and in inheritance of telomeric silencing SAKL0H16764g 1 1474162 1475790 ON 8 H16764 (1474162..1475790) highly similar to gnl|GLV|KLLA0F19404g Kluyveromyces lactis KLLA0F19404g and similar to YDR120C uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase localizes to both the nucleus and mitochondrion to produce the modified base N2 N2- dimethylguanosine in tRNAs in both compartments SAKL0H16786g 0 1476277 1476501 ON 8 H16786 complement(1476277..1476501) similar to uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Pi SAKL0H16808g 0 1477137 1479110 ON 8 H16808 complement(1477137..1479110) weakly similar to uniprot|Q04602 Saccharomyces cerevisiae YDR119W Uncharacterized transporter SAKL0H16830g 0 1479446 1482034 ON 8 H16830 complement(1479446..1482034) similar to uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 High affinity sulfate permease sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p which control the concentration of endogenous activated sulfate intermediates and uniprot|P38359 Saccharomyces cerevisiae YBR294W SUL1 SAKL0H16852g 0 1482321 1484255 ON 8 H16852 complement(1482321..1484255) some similarities with uniprot|Q04601 Saccharomyces cerevisiae YDR118W APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition SAKL0H16874g 1 1484425 1486116 ON 8 H16874 (1484425..1486116) similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C RBF64 Hypothetical ORF SAKL0H16896g 1 1486354 1487211 ON 8 H16896 (1486354..1487211) similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit SAKL0H16918g 0 1487378 1487713 ON 8 H16918 complement(1487378..1487713) similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W SAKL0H16940g 0 1488620 1489531 ON 8 H16940 complement(1488620..1489531) weakly similar to uniprot|Q12393 Saccharomyces cerevisiae YLR091W Hypothetical ORF SAKL0H16962g 1 1489800 1490810 ON 8 H16962 (1489800..1490810) weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin that inhibits anaphase by binding separin Esp1p also blocks cyclin destruction and mitotic exit essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles also present in meiotic nuclei SAKL0H16984g 0 1490925 1492232 ON 8 H16984 complement(1490925..1492232) similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative homolog of E. coli DnaJ closely related to Ydj1p SAKL0H17006g 1 1493272 1494867 ON 8 H17006 (1493272..1494867) highly similar to gnl|GLV|KLLA0F19162g Kluyveromyces lactis KLLA0F19162g and similar to YLR089C uniprot|P52893 Saccharomyces cerevisiae YLR089C ALT1 putative alanine transaminase (glutamyc pyruvic transaminase) SAKL0H17028g 0 1495187 1496839 ON 8 H17028 complement(1495187..1496839) similar to uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities binds to the replication fork barrier site in the rDNA region related to retroviral integrases SAKL0H17050g 0 1497051 1498805 ON 8 H17050 complement(1497051..1498805) similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI:protein transamidase complex removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER SAKL0H17072g 1 1498942 1507935 ON 8 H17072 (1498942..1507935) similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature SAKL0H17094g 0 1508021 1512289 ON 8 H17094 complement(1508021..1512289) similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex which reorganizes chromosomes during cell division forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA- binding activity and promotes knotting of circular DNA potential Cdc28p substrate SAKL0H17116g 0 1512627 1514261 ON 8 H17116 complement(1512627..1514261) weakly similar to uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing SAKL0H17138g 1 1515123 1516382 ON 8 H17138 (1515123..1516382) highly similar to uniprot|Q74ZV8 Ashbya gossypii AGR091W ARP6 Actin-like protein ARP6 and similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Nuclear actin- related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes SAKL0H17160g 1 1516854 1519073 ON 8 H17160 (1516854..1519073) similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein of unknown function and similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF SAKL0H17182g 1 1520135 1522192 ON 8 H17182 (1520135..1522192) some similarities with uniprot|Q74ZV5 Ashbya gossypii AGR094W AGR094Wp SAKL0H17204g 1 1522944 1526579 ON 8 H17204 (1522944..1526579) similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding localization requires Rax1p SAKL0H17226g 0 1526848 1529007 ON 8 H17226 complement(1526848..1529007) similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W GSG1 Subunit of TRAPP (transport protein particle) a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment protein has late meiotic role following DNA replication SAKL0H17248g 1 1530599 1532581 ON 8 H17248 (1530599..1532581) similar to uniprot|P32802 Saccharomyces cerevisiae YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions predicted to be a transmembrane protein Sklu_8.trna21I 1 1533299 1533372 ON 8 tI-AAU (1533299..1533372) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0H17314g 1 1533540 1533827 ON 8 H17314 (1533540..1533827) conserved hypothetical protein SAKL0H17336g 1 1534050 1535000 ON 8 H17336 (1534050..1535000) some similarities with uniprot|P32645 Saccharomyces cerevisiae YER180C ISC10 Protein required for sporulation transcript is induced 7.5 hours after induction of meiosis expected to play significant role in the formation of reproductive cells SAKL0H17358g 0 1535040 1535975 ON 8 H17358 complement(1535040..1535975) weakly similar to uniprot|Q04549 Saccharomyces cerevisiae YDR106W ARP10 Actin-related protein SAKL0H17380g 1 1536124 1537554 ON 8 H17380 (1536124..1537554) similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Putative membrane protein conserved in mammals SAKL0H17402g 0 1537652 1538736 ON 8 H17402 complement(1537652..1538504,1538663..1538736) similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein SAKL0H17424g 0 1539238 1540476 ON 8 H17424 complement(1539238..1540476) conserved hypothetical protein SAKL0H17446g 0 1540871 1542706 ON 8 H17446 complement(1540871..1542706) similar to uniprot|Q03862 Saccharomyces cerevisiae YDR101C ARX1 Protein associated with the ribosomal export complex SAKL0H17468g 1 1543179 1544402 ON 8 H17468 (1543179..1544402) highly similar to uniprot|P16387 Saccharomyces cerevisiae YER178W PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex SAKL0H17490g 1 1545415 1548159 ON 8 H17490 (1545415..1548159) similar to uniprot|Q74ZU4 Ashbya gossypii AGR104W AGR104Wp and weakly similar to YDR103W uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Scaffold protein that in response to pheromone shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p Ste7p and Fus3p into a specific signaling complex active oligomeric form interacts with Ste4p-Ste18p complex SAKL0H17512g 0 1548246 1551959 ON 8 H17512 complement(1548246..1551959) similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis SAKL0H17534g 0 1552600 1553016 ON 8 H17534 complement(1552600..1553016) similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Tlg2-Vesicle Protein of 15 kDa integral membrane vesicle protein SAKL0H17556g 0 1554245 1555012 ON 8 H17556 complement(1554245..1555012) highly similar to uniprot|P34730 Saccharomyces cerevisiae YDR099W BMH2 14-3-3 protein minor isoform binds proteins and DNA involved in regulation of many processes including exocytosis and vesicle transport Ras/MAPK signaling during pseudohyphal development rapamycin- sensitive signaling and others SAKL0H17578g 1 1557775 1558284 ON 8 H17578 (1557775..1558284) no similarity Sklu_8.trna22Q 1 1559720 1559791 ON 8 tQ-UUG (1559720..1559791) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 68.39 SAKL0H17666g 0 1560676 1564065 ON 8 H17666 complement(1560676..1564065) similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination interacts with the translation termination factors localized to polysomes SAKL0H17688g 1 1564582 1565445 ON 8 H17688 (1564582..1565445) similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase SAKL0H17710g 1 1565867 1566592 ON 8 H17710 (1565867..1566592) similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage SAKL0H17732g 0 1566718 1568736 ON 8 H17732 complement(1566718..1568736) similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein SAKL0H17754g 1 1569016 1575546 ON 8 H17754 (1569016..1575546) similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis SAKL0H17776g 0 1575666 1578020 ON 8 H17776 complement(1575666..1578020) highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein SAKL0H17798g 0 1578407 1579183 ON 8 H17798 complement(1578407..1579183) similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background SAKL0H17820g 1 1579463 1583215 ON 8 H17820 (1579463..1583215) similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p SAKL0H17842g 0 1584215 1586659 ON 8 H17842 complement(1584215..1586659) similar to uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway SAKL0H17864g 1 1587902 1589461 ON 8 H17864 (1587902..1589461) similar to uniprot|P21269 Saccharomyces cerevisiae YER168C CCA1 tRNA nucleotidyltransferase (tRNA CCA- pyrophosphorylase) SAKL0H17886g 0 1590034 1592208 ON 8 H17886 complement(1590034..1592208) weakly similar to uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations SAKL0H17908g 0 1592937 1597664 ON 8 H17908 complement(1592937..1597664) similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport SAKL0H17930g 0 1598218 1598741 ON 8 H17930 complement(1598218..1598649,1598712..1598741) highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus SAKL0H17952g 0 1599134 1600903 ON 8 H17952 complement(1599134..1600903) highly similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G SAKL0H17974g 0 1601236 1605633 ON 8 H17974 complement(1601236..1605633) similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator SAKL0H17996g 1 1607260 1609323 ON 8 H17996 (1607260..1609323) highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis SAKL0H18018g 1 1609922 1610623 ON 8 H18018 (1609922..1610623) similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF SAKL0H18040g 1 1610762 1611571 ON 8 H18040 (1610762..1611571) similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Hypothetical ORF SAKL0H18062g 1 1611760 1614315 ON 8 H18062 (1611760..1614315) similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) homolog of human XPC protein SAKL0H18084g 1 1614509 1615480 ON 8 H18084 (1614509..1615480) similar to gnl|GLV|CAGL0L11704g Candida glabrata CAGL0L11704g and weakly similar to uniprot|P06843 Saccharomyces cerevisiae YER161c SPT2 multifunctional HMG- like chromatin protein SAKL0H18106g 0 1615646 1618177 ON 8 H18106 complement(1615646..1618177) similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Hypothetical ORF Sklu_8.trna23R 0 1618837 1618930 ON 8 tR-ACG complement(1618837..1618872,1618894..1618930) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 64.63 SAKL0H18172g 1 1619927 1621024 ON 8 H18172 (1619927..1621024) similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 Protein involved in 3' splice site choices acts in concert with Prp18p during the 2nd step of splicing SAKL0H18194g 1 1621183 1622001 ON 8 H18194 (1621183..1622001) similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing SAKL0H18216g 1 1622092 1622424 ON 8 H18216 (1622092..1622424) similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex SAKL0H18238g 1 1622863 1623246 ON 8 H18238 (1622863..1623246) similar to uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone- fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha SAKL0H18260g 1 1624812 1626371 ON 8 H18260 (1624812..1626371) conserved hypothetical protein SAKL0H18282g 1 1626899 1629217 ON 8 H18282 (1626899..1629217) some similarities with uniprot|P33304 Saccharomyces cerevisiae YDR085C Sklu_8.trna24E 1 1629629 1629700 ON 8 tE-UUC (1629629..1629700) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0H18326g 1 1629973 1630560 ON 8 H18326 (1629973..1630560) similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern SAKL0H18348g 0 1630626 1631783 ON 8 H18348 complement(1630626..1631783) similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8 SAKL0H18370g 0 1631970 1633406 ON 8 H18370 complement(1631970..1633406) weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase SAKL0H18392g 1 1633555 1633998 ON 8 H18392 (1633555..1633998) conserved hypothetical protein SAKL0H18414g 1 1634636 1637023 ON 8 H18414 (1634636..1637023) similar to gnl|GLV|KLLA0C11781g Kluyveromyces lactis KLLA0C11781g and some similarites with YDR081C uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase required for high level expression of both the THI and the PDC genes SAKL0H18436g 0 1637161 1640109 ON 8 H18436 complement(1637161..1640109) similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex SAKL0H18458g 1 1640259 1640477 ON 8 H18458 (1640259..1640477) highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH involved in transcription initiation homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair SAKL0H18480g 0 1640557 1642861 ON 8 H18480 complement(1640557..1642719,1642790..1642861) similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments SAKL0H18502g 0 1643503 1643910 ON 8 H18502 complement(1643503..1643910) similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane SAKL0H18524g 1 1644149 1645153 ON 8 H18524 (1644149..1645153) highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF SAKL0H18546g 1 1646518 1652601 ON 8 H18546 (1646518..1652601) similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence SAKL0H18568g 0 1652887 1653951 ON 8 H18568 complement(1652887..1653951) similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient SAKL0H18590g 1 1654350 1655288 ON 8 H18590 (1654350..1655288) uniprot|O13377 Saccharomyces kluyveri PET122 Protein PET122, mitochondrial precursor SAKL0H18612g 1 1655787 1657124 ON 8 H18612 (1655787..1657124) highly similar to gnl|GLV|KLLA0E00935g Kluyveromyces lactis KLLA0E00935g and similar to YER152C uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF SAKL0H18634g 1 1657472 1658239 ON 8 H18634 (1657472..1658239) similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity SAKL0H18656g 1 1658629 1660947 ON 8 H18656 (1658629..1660947) some similarities with uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin Sklu_8.trna25V 0 1661080 1661153 ON 8 tV-AAC complement(1661080..1661153) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0H18700g 0 1663278 1663775 ON 8 H18700 complement(1663278..1663775) some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077W SED1 Isolated as a suppressor of an erd2 deletion mutant (ERD2 is the HDEL receptor that sorts ER proteins) SED1 encodes a cell wall protein. SAKL0H18722g 0 1664234 1665349 ON 8 H18722 complement(1664234..1665349) weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p SAKL0H18744g 0 1665668 1666591 ON 8 H18744 complement(1665668..1666591) highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization SAKL0H18766g 1 1666901 1668097 ON 8 H18766 (1666901..1668097) weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis cell fusion and low affinity Ca2 influx forms polarisome complex with Bni1p Bud6p and Spa2p localizes to sites of polarized growth SAKL0H18788g 0 1668245 1668973 ON 8 H18788 complement(1668245..1668973) highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability SAKL0H18810g 1 1669319 1671220 ON 8 H18810 (1669319..1671220) similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4 SAKL0H18832g 0 1671403 1674126 ON 8 H18832 complement(1671403..1674126) highly similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6-phosphate phosphatase SAKL0H18854g 0 1674645 1674986 ON 8 H18854 complement(1674645..1674986) similar to gnl|GLV|CAGL0G05329g Candida glabrata CAGL0G05329g and some similarites with YDR073W uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex SAKL0H18876g 1 1675974 1677449 ON 8 H18876 (1675974..1677449) similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media SAKL0H18898g 0 1677858 1678100 ON 8 H18898 complement(1677858..1678100) similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay SAKL0H18920g 1 1678840 1679961 ON 8 H18920 (1678840..1679961) similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron SAKL0H18942g 1 1681341 1681922 ON 8 H18942 (1681341..1681922) highly similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation SAKL0H18964g 1 1682727 1683065 ON 8 H18964 (1682727..1683065) conserved hypothetical protein SAKL0H18986g 1 1683752 1686433 ON 8 H18986 (1683752..1686433) similar to uniprot|P32571 Saccharomyces cerevisiae YDR069C DOA4 Ubiquitin hydrolase required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole SAKL0H19008g 0 1686525 1687469 ON 8 H19008 complement(1686525..1687469) similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm SAKL0H19030g 1 1687656 1688300 ON 8 H19030 (1687656..1688300) similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0H19052g 0 1688334 1689527 ON 8 H19052 complement(1688334..1689527) similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control SAKL0H19074g 1 1690078 1690911 ON 8 H19074 (1690078..1690911) similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired SAKL0H19096g 0 1691002 1692453 ON 8 H19096 complement(1691002..1692453) similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase SAKL0H19118g 0 1693449 1694939 ON 8 H19118 complement(1693449..1694939) similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF SAKL0H19140g 1 1695087 1695758 ON 8 H19140 (1695087..1695758) similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF SAKL0H19162g 0 1695802 1696920 ON 8 H19162 complement(1695802..1696920) similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF Sklu_8.trna26V 1 1698745 1698818 ON 8 tV-AAC (1698745..1698818) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0H19228g 0 1699478 1700425 ON 8 H19228 complement(1699478..1699912,1700405..1700425) highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins SAKL0H19250g 0 1700691 1701137 ON 8 H19250 complement(1700691..1701137) similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF SAKL0H19272g 0 1701420 1703108 ON 8 H19272 complement(1701420..1703108) highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3- ketosphinganine SAKL0H19294g 0 1703651 1705213 ON 8 H19294 complement(1703651..1705213) similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP-binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance SAKL0H19316g 0 1705548 1707941 ON 8 H19316 complement(1705548..1707941) similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N-linked and O- linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family SAKL0H19338g 1 1708861 1710204 ON 8 H19338 (1708861..1710204) highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins SAKL0H19360g 1 1710894 1711251 ON 8 H19360 (1710894..1710947,1711018..1711251) highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay SAKL0H19382g 0 1711498 1711941 ON 8 H19382 complement(1711498..1711941) similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Hypothetical ORF SAKL0H19426g 1 1713041 1713457 ON 8 H19426 (1713041..1713457) similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit SAKL0H19448g 1 1713663 1715738 ON 8 H19448 (1713663..1715738) highly similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W SAKL0H19470g 0 1715913 1718567 ON 8 H19470 complement(1715913..1718567) similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex SAKL0H19492g 1 1718719 1719795 ON 8 H19492 (1718719..1719795) conserved hypothetical protein SAKL0H19514g 0 1719913 1721433 ON 8 H19514 complement(1719913..1721433) similar to uniprot|P38067 Saccharomyces cerevisiae YBR006w UGA2 succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source SAKL0H19536g 0 1721654 1724920 ON 8 H19536 complement(1721654..1724920) similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria SAKL0H19558g 0 1725153 1725833 ON 8 H19558 complement(1725153..1725833) highly similar to gnl|GLV|CAGL0J04400g Candida glabrata CAGL0J04400g and similar to YBL021C uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme- activated glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression contains sequences contributing to both complex assembly and DNA binding SAKL0H19580g 1 1726004 1727704 ON 8 H19580 (1726004..1727704) similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane mutation is suppressed by expression human p53 protein SAKL0H19602g 1 1727992 1729581 ON 8 H19602 (1727992..1729581) similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII SAKL0H19624g 0 1729632 1729937 ON 8 H19624 complement(1729632..1729937) similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends SAKL0H19646g 0 1731049 1735704 ON 8 H19646 complement(1731049..1735704) similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments SAKL0H19668g 1 1736301 1737674 ON 8 H19668 (1736301..1737674) highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phoshporylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets SAKL0H19690g 1 1738416 1739987 ON 8 H19690 (1738416..1739987) highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth Sklu_8.trna27I 0 1740262 1740335 ON 8 tI-AAU complement(1740262..1740335) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 70.08 SAKL0H19767g1 1 1740696 1742018 ON 8 H19767 (1740696..1742018) Retrotransposon Gag gene Sklu_8.trna28H 1 1746443 1746514 ON 8 tH-GUG (1746443..1746514) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 Sklu_8.trna29P 0 1746658 1746761 ON 8 tP-UGG complement(1746658..1746693,1746726..1746761) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.25 SAKL0H19866g 1 1747531 1748067 ON 8 H19866 (1747531..1748067) highly similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF Sklu_8.trna30K 1 1749582 1749654 ON 8 tK-CUU (1749582..1749654) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 73.70 SAKL0H19976g 0 1750403 1750834 ON 8 H19976 complement(1750403..1750834) similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane Sklu_8.trna31P 1 1751894 1751997 ON 8 tP-UGG (1751894..1751929,1751962..1751997) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.25 SAKL0H20020g 0 1752241 1754166 ON 8 H20020 complement(1752241..1754166) highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family SAKL0H20042g 0 1754870 1755661 ON 8 H20042 complement(1754870..1755661) similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF SAKL0H20064g 0 1755850 1756905 ON 8 H20064 complement(1755850..1756905) conserved hypothetical protein SAKL0H20086g 1 1757394 1758917 ON 8 H20086 (1757394..1758917) similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM SAKL0H20108g 1 1759515 1763222 ON 8 H20108 (1759515..1763222) weakly similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)- transporting ATPase Sklu_8.trna32F 1 1764226 1764318 ON 8 tF-GAA (1764226..1764262,1764283..1764318) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.28 SAKL0H20174g 1 1764879 1769282 ON 8 H20174 (1764879..1769282) weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate SAKL0H20196g 0 1769526 1770236 ON 8 H20196 complement(1769526..1770236) similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit SAKL0H20218g 1 1770946 1772670 ON 8 H20218 (1770946..1772670) similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis SAKL0H20240g 0 1773345 1773704 ON 8 H20240 complement(1773345..1773704) highly similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase SAKL0H20262g 1 1774365 1775828 ON 8 H20262 (1774365..1775828) similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Hypothetical ORF SAKL0H20284g 0 1775996 1778734 ON 8 H20284 complement(1775996..1778734) highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre- replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p SAKL0H20306g 0 1779248 1781161 ON 8 H20306 complement(1779248..1781161) some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I) SAKL0H20328g 0 1781430 1783028 ON 8 H20328 complement(1781430..1783028) some similarities with uniprot|P45819 Saccharomyces cerevisiae YGL170C SPO74 Component of the meiotic outer plaque of the spindle pole body involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation SAKL0H20350g 1 1783371 1783766 ON 8 H20350 (1783371..1783766) similar to uniprot|P32601 Saccharomyces cerevisiae YPR017C DSS4 Nucleotide release factor functioning in the post-Golgi secretory pathway required for ER-to-Golgi transport binds zinc found both on membranes and in the cytosol guanine nucleotide dissociation stimulator SAKL0H20372g 1 1784643 1785380 ON 8 H20372 (1784643..1785380) highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton SAKL0H20394g 1 1787390 1788469 ON 8 H20394 (1787390..1788469) weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0H20416g 1 1789596 1790549 ON 8 H20416 (1789596..1790549) weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF SAKL0H20438g 1 1793911 1796272 ON 8 H20438 (1793911..1793929,1794594..1796272) weakly similar to gnl|GLV|DEHA0C12881g Debaryomyces hansenii DEHA0C12881g Sklu_8.trna33L 1 1797294 1797400 ON 8 tL-UAG (1797294..1797330,1797357..1797400) tRNA Type: Leu (L) | Anti-Codon: UAG | Cove Score: 62.91 SAKL0H20482g 1 1797755 1798726 ON 8 H20482 (1797755..1798726) highly similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C Hypothetical ORF SAKL0H20504g 1 1799054 1799594 ON 8 H20504 (1799054..1799086,1799409..1799594) conserved hypothetical protein SAKL0H20526g 0 1800560 1802419 ON 8 H20526 complement(1800560..1802419) conserved hypothetical protein SAKL0H20548g 0 1803426 1804286 ON 8 H20548 complement(1803426..1804286) similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF SAKL0H20570g 1 1804781 1805137 ON 8 H20570 (1804781..1805137) highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector SAKL0H20592g 0 1805321 1806847 ON 8 H20592 complement(1805321..1806847) some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating SAKL0H20614g 1 1809584 1810294 ON 8 H20614 (1809584..1810294) some similarities with uniprot|P38723 Saccharomyces cerevisiae YHL048W COS8 Nuclear membrane protein member of a family of conserved often subtelomerically-encoded proteins regulation suggests a potential role in the unfolded protein response SAKL0H20636g 1 1810817 1811494 ON 8 H20636 (1810817..1811494) weakly similar to uniprot|P25354 Saccharomyces cerevisiae YCR007C Putative integral membrane protein member of DUP240 gene family SAKL0H20658g 0 1811772 1813187 ON 8 H20658 complement(1811772..1813187) highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization SAKL0H20680g 0 1813811 1814719 ON 8 H20680 complement(1813811..1814719) similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Hypothetical ORF Sklu_8.trna34L 1 1815756 1815877 ON 8 tL-CAA (1815756..1815793,1815834..1815877) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 51.83 SAKL0H20724g 0 1816324 1816941 ON 8 H20724 complement(1816324..1816941) similar to uniprot|Q754A8 Ashbya gossypii AFR164W AFR164Wp and some similarites with YGL105W uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids SAKL0H20746g 1 1817259 1818014 ON 8 H20746 (1817259..1818014) similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases Sklu_8.trna35A 0 1818221 1818293 ON 8 tA-AGC complement(1818221..1818293) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 70.93 SAKL0H20856g 0 1819844 1821241 ON 8 H20856 complement(1819844..1821241) similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins SAKL0H20878g 0 1821813 1822448 ON 8 H20878 complement(1821813..1822448) similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD( ) salvage pathway gene pyrazinamidase and nicotinamidase SAKL0H20900g 1 1823306 1825813 ON 8 H20900 (1823306..1825813) weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2 SAKL0H20922g 1 1826071 1828179 ON 8 H20922 (1826071..1828179) highly similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p SAKL0H20944g 1 1828722 1830347 ON 8 H20944 (1828722..1830347) similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane SAKL0H20966g 0 1831362 1831754 ON 8 H20966 complement(1831362..1831754) conserved hypothetical protein SAKL0H20988g 0 1832478 1834124 ON 8 H20988 complement(1832478..1834124) weakly similar to uniprot|P27705 Saccharomyces cerevisiae YGL035C MIG1 Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins SAKL0H21010g 1 1835185 1839528 ON 8 H21010 (1835185..1839528) similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter Sklu_8.trna36G 1 1840441 1840511 ON 8 tG-GCC (1840441..1840511) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0H21076g 1 1840660 1841365 ON 8 H21076 (1840660..1840711,1840794..1841365) similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair SAKL0H21098g 1 1842225 1843148 ON 8 H21098 (1842225..1843148) conserved hypothetical protein SAKL0H21120g 0 1843394 1844089 ON 8 H21120 complement(1843394..1844089) similar to gnl|GLV|CAGL0E03003g Candida glabrata CAGL0E03003g and weakly similar to YGR147C uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha-acetyl- transferase transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins SAKL0H21142g 0 1844660 1844956 ON 8 H21142 complement(1844660..1844956) similar to uniprot|P32781 Saccharomyces cerevisiae YGL032C AGA2 Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds SAKL0H21164g 0 1845674 1846123 ON 8 H21164 complement(1845674..1846123) similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B SAKL0H21186g 1 1847428 1847927 ON 8 H21186 (1847428..1847430,1847613..1847927) highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit SAKL0H21208g 1 1848202 1849437 ON 8 H21208 (1848202..1849437) similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Hypothetical ORF SAKL0H21230g 0 1849982 1852651 ON 8 H21230 complement(1849982..1852651) similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C Hypothetical ORF SAKL0H21252g 1 1852884 1853276 ON 8 H21252 (1852884..1853276) similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents expression is growth-regulated Sklu_8.trna37F 0 1853495 1853587 ON 8 tF-GAA complement(1853495..1853530,1853551..1853587) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 69.92 SAKL0H21296g 1 1853724 1854716 ON 8 H21296 (1853724..1854716) conserved hypothetical protein SAKL0H21318g 0 1854956 1856677 ON 8 H21318 complement(1854956..1856677) similar to uniprot|P53189 Saccharomyces cerevisiae YGL028C SAKL0H21340g 0 1858441 1863654 ON 8 H21340 complement(1858441..1863654) no similarity SAKL0H21362g 0 1864400 1867561 ON 8 H21362 complement(1864400..1867561) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) SAKL0H21384g 0 1869636 1872065 ON 8 H21384 complement(1869636..1872065) similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I involved in assembly of cell wall beta 1 6 glucan and asparagine- linked protein glycosylation ER type II integral membrane N-glycoprotein disruption leads to a K1 killer toxin- resistant phenotype SAKL0H21406g 0 1872625 1875438 ON 8 H21406 complement(1872625..1875438) similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn7p and TATA-binding protein SAKL0H21428g 0 1875639 1877840 ON 8 H21428 complement(1875639..1877840) highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 tryptophan synthetase SAKL0H21450g 0 1877976 1879100 ON 8 H21450 complement(1877976..1879100) some similarities with uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the Mediator global transcriptional cofactor complex which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription direct target of the Cyc8p-Tup1p transcriptional corepressor SAKL0H21472g 0 1879578 1880471 ON 8 H21472 complement(1879578..1880471) conserved hypothetical protein SAKL0H21494g 1 1880576 1881682 ON 8 H21494 (1880576..1881682) similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase catalyzes the formylation of initiator Met-tRNA in mitochondria potential Cdc28p substrate Sklu_8.trna38D 0 1881880 1881951 ON 8 tD-GUC complement(1881880..1881951) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 67.35 SAKL0H21560g 1 1883204 1885390 ON 8 H21560 (1883204..1885390) similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline-transport mutants SAKL0H21582g 0 1886001 1887812 ON 8 H21582 complement(1886001..1887812) weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C SAKL0H21604g 1 1888893 1891295 ON 8 H21604 (1888893..1891295) highly similar to gnl|GLV|KLLA0C11627g Kluyveromyces lactis KLLA0C11627g and some similarites with YGL022W uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis SAKL0H21626g 0 1891424 1892242 ON 8 H21626 complement(1891424..1892242) weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C Hypothetical ORF SAKL0H21648g 1 1892798 1894882 ON 8 H21648 (1892798..1894882) weakly similar to uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin SAKL0H21670g 0 1895116 1895754 ON 8 H21670 complement(1895116..1895754) weakly similar to uniprot|P53192 Saccharomyces cerevisiae YGL020C MDM39 Protein involved in determination of mitochondrial structure SAKL0H21692g 1 1895921 1896703 ON 8 H21692 (1895921..1896703) similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2 SAKL0H21714g 0 1896815 1897372 ON 8 H21714 complement(1896815..1897372) similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Molecular chaperone involved with partner Ssq1p in assembly of Fe/S clusters and in mitochondrial iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix Sklu_8.trna39E 1 1897565 1897636 ON 8 tE-UUC (1897565..1897636) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 SAKL0H21758g 1 1897866 1899494 ON 8 H21758 (1897866..1899494) similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway SAKL0H21780g 0 1899549 1899860 ON 8 H21780 complement(1899549..1899860) no similarity SAKL0H21802g 1 1900539 1903367 ON 8 H21802 (1900539..1903367) similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance SAKL0H21824g 1 1903887 1905386 ON 8 H21824 (1903887..1905386) similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis SAKL0H21846g 1 1905888 1908134 ON 8 H21846 (1905888..1908134) similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes contributes to nucleosome formation heterochromatic gene silencing and formation of functional kinetochores SAKL0H21868g 1 1908378 1910726 ON 8 H21868 (1908378..1910726) highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase catalyzes the second step in the leucine biosynthesis pathway SAKL0H21890g 0 1910870 1913074 ON 8 H21890 complement(1910870..1913074) similar to gnl|GLV|DEHA0C12617g Debaryomyces hansenii DEHA0C12617g and weakly similar to YBL097W uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics SAKL0H21912g 0 1913307 1917068 ON 8 H21912 complement(1913307..1917068) similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton contains 3 SH3 domains interacts with proteins regulating actin dynamics and with proteins required for endocytosis SAKL0H21934g 0 1917367 1917879 ON 8 H21934 complement(1917367..1917879) similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W Hypothetical ORF SAKL0H21956g 1 1918407 1919153 ON 8 H21956 (1918407..1919153) highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) SAKL0H21978g 0 1919288 1919881 ON 8 H21978 complement(1919288..1919881) similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Protein of unknown function null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface SAKL0H22000g 0 1921450 1922841 ON 8 H22000 complement(1921450..1922841) highly similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase catalyzes the final step in ergosterol biosynthesis mutants are viable but lack ergosterol SAKL0H22022g 0 1923392 1925767 ON 8 H22022 complement(1923392..1925767) similar to uniprot|Q750N6 Ashbya gossypii AGL086C AGL086Cp and some similarites with YGL014W uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 member of the PUF protein family YGL014W SAKL0H22044g 1 1926684 1927886 ON 8 H22044 (1926684..1927886) highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) homologous to Oye3p with slight differences in ligand binding and catalytic properties may be involved in sterol metabolism SAKL0H22066g 0 1928419 1931115 ON 8 H22066 complement(1928419..1931115) highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H -ATPase pumps protons out of the cell major regulator of cytoplasmic pH part of the P2 subgroup of cation-transporting ATPases SAKL0H22088g 1 1934171 1935301 ON 8 H22088 (1934171..1935301) similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance Sklu_8.trna40A 0 1935455 1935527 ON 8 tA-UGC complement(1935455..1935527) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 73.87 Sklu_8.trna41S 0 1937041 1937148 ON 8 tS-AGA complement(1937041..1937085,1937112..1937148) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 71.12 SAKL0H22264g 0 1937504 1938367 ON 8 H22264 complement(1937504..1938367) similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W SAKL0H22286g 1 1938854 1942702 ON 8 H22286 (1938854..1942702) similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 May be involved in depleting cytosol of Ca2 ions putative vacuolar Ca2 ATPase SAKL0H22308g 0 1942948 1943727 ON 8 H22308 complement(1942948..1943727) similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex SAKL0H22330g 0 1943859 1945094 ON 8 H22330 complement(1943859..1945094) similar to uniprot|P53196 Saccharomyces cerevisiae YGL004C RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome localized to the cytoplasm SAKL0H22352g 1 1945309 1947177 ON 8 H22352 (1945309..1947177) highly similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination SAKL0H22374g 1 1947498 1949420 ON 8 H22374 (1947498..1949420) conserved hypothetical protein SAKL0H22396g 0 1949474 1951141 ON 8 H22396 complement(1949474..1951141) similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 CDC20 homolog 1 protein required for Clb2 and Ase1 degradation SAKL0H22418g 0 1951429 1952724 ON 8 H22418 complement(1951429..1952724) similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres SAKL0H22440g 1 1952902 1953561 ON 8 H22440 (1952902..1953561) similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A ERP1 Protein that forms a heterotrimeric complex with Erp2p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles SAKL0H22462g 0 1954543 1956181 ON 8 H22462 complement(1954543..1956024,1956101..1956181) weakly similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC) functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP potential Cdc28p substrate Sklu_8.trna42P 0 1956316 1956419 ON 8 tP-UGG complement(1956316..1956351,1956384..1956419) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 61.89 SAKL0H22528g 0 1957632 1958204 ON 8 H22528 complement(1957632..1958204) some similarities with uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta- glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein SAKL0H22550g 0 1958491 1962163 ON 8 H22550 complement(1958491..1961990,1962073..1962163) similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding SAKL0H22572g 1 1962338 1963210 ON 8 H22572 (1962338..1962366,1962434..1962912,1962978..1963210) highly similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Protein with similarity to methyltransferase family members; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Sklu_CEN8 0 1963599 1963796 ON 8 CEN8 complement(1963599..1963796) Chromosome VIII centromere SAKL0H22594g 1 1964470 1965519 ON 8 H22594 (1964470..1965519) highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis SAKL0H22616g 0 1966196 1968421 ON 8 H22616 complement(1966196..1968421) similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment SAKL0H22638g 0 1968593 1972378 ON 8 H22638 complement(1968593..1972378) similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2 binding motif. SAKL0H22660g 0 1972651 1973535 ON 8 H22660 complement(1972651..1973200,1973456..1973535) highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta SAKL0H22704g 1 1974031 1975131 ON 8 H22704 (1974031..1975131) similar to uniprot|Q754R8 Ashbya gossypii AFR004W SFH1 Chromatin structure remodeling complex protein SFH1 and some similarites with uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC SAKL0H22726g 1 1975369 1975869 ON 8 H22726 (1975369..1975869) weakly similar to uniprot|Q06162 Saccharomyces cerevisiae YLR315W NKP2 SAKL0H22748g 0 1975851 1976963 ON 8 H22748 complement(1975851..1976670,1976737..1976788,1976855..1976963) similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p SAKL0H22770g 1 1977119 1979731 ON 8 H22770 (1977119..1979731) similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function SAKL0H22792g 0 1980026 1982302 ON 8 H22792 complement(1980026..1982302) weakly similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate SAKL0H22814g 1 1982481 1986920 ON 8 H22814 (1982481..1986920) similar to gnl|GLV|KLLA0C18337g Kluyveromyces lactis KLLA0C18337g and some similarites with YLR320W uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks SAKL0H22836g 0 1986975 1988345 ON 8 H22836 complement(1986975..1988345) similar to uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex SAKL0H22858g 1 1988530 1990740 ON 8 H22858 (1988530..1990740) similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W SAKL0H22880g 0 1990748 1991578 ON 8 H22880 complement(1990748..1991578) similar to uniprot|P53769 Saccharomyces cerevisiae YLR323C SAKL0H22902g 1 1991718 1993349 ON 8 H22902 (1991718..1993349) similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p SAKL0H22924g 0 1993614 1993850 ON 8 H22924 complement(1993614..1993850) highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit SAKL0H22946g 0 1994127 1995278 ON 8 H22946 complement(1994127..1995278) similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit SAKL0H22968g 1 1995497 1996207 ON 8 H22968 (1995497..1996207) similar to uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p SAKL0H22990g 1 1996768 1997617 ON 8 H22990 (1996768..1996867,1996971..1997617) similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF SAKL0H23012g 1 1998095 1999048 ON 8 H23012 (1998095..1999048) similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase SAKL0H23034g 0 1999163 1999423 ON 8 H23034 complement(1999163..1999423) similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF and YGR008C uniprot|P16965 Saccharomyces cerevisiae YGR008C STF2 ATPase stabilizing factor Sklu_8.trna43S 1 2001941 2002043 ON 8 tS-GCU (2001941..2001977,2001999..2002043) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 67.29 SAKL0H23100g 1 2002374 2003555 ON 8 H23100 (2002374..2003555) highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD( ) salvage pathway SAKL0H23122g 1 2004664 2005311 ON 8 H23122 (2004664..2005311) no similarity SAKL0H23144g 1 2005986 2007158 ON 8 H23144 (2005986..2007158) highly similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF SAKL0H23166g 1 2007625 2009382 ON 8 H23166 (2007625..2009382) weakly similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein SAKL0H23188g 1 2009677 2013465 ON 8 H23188 (2009677..2013465) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) SAKL0H23210g 0 2013815 2014777 ON 8 H23210 complement(2013815..2014777) similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF SAKL0H23232g 1 2015731 2016306 ON 8 H23232 (2015731..2016306) similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF SAKL0H23254g 0 2016281 2016739 ON 8 H23254 complement(2016281..2016739) weakly similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W REC102 Protein involved in early stages of meiotic recombination required for chromosome synapsis forms a complex with Rec104p and Spo11p necessary during the initiation of recombination SAKL0H23276g 0 2019038 2020393 ON 8 H23276 complement(2019038..2020393) some similarities with uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein SAKL0H23298g 0 2021024 2021797 ON 8 H23298 complement(2021024..2021797) similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p SAKL0H23320g 1 2022223 2023086 ON 8 H23320 (2022223..2023086) similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS SAKL0H23342g 1 2023346 2023774 ON 8 H23342 (2023346..2023774) similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry SAKL0H23364g 0 2023937 2025424 ON 8 H23364 complement(2023937..2025424) highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis SAKL0H23386g 0 2026177 2027079 ON 8 H23386 complement(2026177..2027079) conserved hypothetical protein SAKL0H23408g 1 2027635 2028282 ON 8 H23408 (2027635..2028282) similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative) SAKL0H23430g 0 2028891 2029913 ON 8 H23430 complement(2028891..2029913) highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta- aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus SAKL0H23452g 1 2030149 2030859 ON 8 H23452 (2030149..2030859) conserved hypothetical protein Sklu_8.trna44L 0 2030979 2031101 ON 8 tL-CAA complement(2030979..2031022,2031064..2031101) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 52.10 SAKL0H23496g 1 2031731 2034367 ON 8 H23496 (2031731..2034367) similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl-ethanolamine N-methyltransferase SAKL0H23518g 0 2034480 2035196 ON 8 H23518 complement(2034480..2035196) similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH SAKL0H23540g 0 2035445 2037097 ON 8 H23540 complement(2035445..2037097) similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8 SAKL0H23562g 0 2037551 2038816 ON 8 H23562 complement(2037551..2038816) some similarities with uniprot|Q754G3 Ashbya gossypii AFR107W AFR107Wp and some similarites with YGR159C uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre-rRNA processing and ribosome biogenesis SAKL0H23584g 0 2039394 2040980 ON 8 H23584 complement(2039394..2040980) no similarity SAKL0H23606g 0 2042655 2043590 ON 8 H23606 complement(2042655..2043590) some similarities with uniprot|P53289 Saccharomyces cerevisiae YGR161C RTS3 Hypothetical ORF Sklu_8.trna45V 1 2044362 2044435 ON 8 tV-AAC (2044362..2044435) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 SAKL0H23650g 0 2045042 2045638 ON 8 H23650 complement(2045042..2045638) similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W SAKL0H23672g 1 2045883 2047109 ON 8 H23672 (2045883..2047109) highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates bound by ubiquitin- protein ligases Ubr1p and Ufd4p localized mainly to the nucleus throughout the cell cycle SAKL0H23694g 1 2047752 2050763 ON 8 H23694 (2047752..2050763) some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220 SAKL0H23716g 0 2051067 2051894 ON 8 H23716 complement(2051067..2051894) similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W Hypothetical ORF SAKL0H23738g 1 2052301 2053406 ON 8 H23738 (2052301..2052362,2052437..2053406) highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins Sklu_8.trna46R 0 2053717 2053788 ON 8 tR-UCU complement(2053717..2053788) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 67.89 SAKL0H23804g 0 2054460 2056217 ON 8 H23804 complement(2054460..2056217) weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase Sklu_8.trna47L 1 2058668 2058773 ON 8 tL-UAG (2058668..2058704,2058730..2058773) tRNA Type: Leu (L) | Anti-Codon: UAG | Cove Score: 63.42 SAKL0H23892g 1 2059083 2060411 ON 8 H23892 (2059083..2060411) highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis Sklu_8.trna48L 1 2061523 2061629 ON 8 tL-UAG (2061523..2061559,2061586..2061629) tRNA Type: Leu (L) | Anti-Codon: UAG | Cove Score: 63.04 SAKL0H23958g 0 2062067 2066743 ON 8 H23958 complement(2062067..2066743) similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p Sklu_8.trna49I 1 2068031 2068104 ON 8 tI-AAU (2068031..2068104) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 71.40 SAKL0H24046g 0 2068626 2070953 ON 8 H24046 complement(2068626..2070953) highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy SAKL0H24068g 0 2071676 2077408 ON 8 H24068 complement(2071676..2077408) similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway required for normal vacuole morphology cell wall integrity and actin cytoskeleton organization SAKL0H24090g 1 2078621 2080357 ON 8 H24090 (2078621..2080357) weakly similar to gnl|GLV|CAGL0D00286g Candida glabrata CAGL0D00286g SAKL0H24112g 1 2080968 2081584 ON 8 H24112 (2080968..2080970,2081030..2081584) similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes SAKL0H24134g 0 2081845 2082093 ON 8 H24134 complement(2081845..2082093) similar to uniprot|Q3E825 Saccharomyces cerevisiae YLR307C-A Identified by homology to Ashbya gossypii SAKL0H24156g 1 2083135 2084115 ON 8 H24156 (2083135..2084115) highly similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall SAKL0H24178g 0 2084600 2085463 ON 8 H24178 complement(2084600..2085463) similar to uniprot|P38892 Saccharomyces cerevisiae YHR209W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0H24200g 0 2086545 2089436 ON 8 H24200 complement(2086545..2089436) similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi SAKL0H24222g 0 2089734 2094314 ON 8 H24222 complement(2089734..2094314) similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1 SAKL0H24244g 1 2095306 2096982 ON 8 H24244 (2095306..2096982) similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation SAKL0H24266g 1 2097613 2097900 ON 8 H24266 (2097613..2097900) highly similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein SAKL0H24288g 1 2099353 2101317 ON 8 H24288 (2099353..2101317) similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases which are serine/threonine kinases also capable of phosphorylating tyrosine residues SAKL0H24310g 0 2102514 2103605 ON 8 H24310 complement(2102514..2103605) weakly similar to uniprot|Q06159 Saccharomyces cerevisiae YLR312C Hypothetical ORF SAKL0H24332g 0 2103877 2105250 ON 8 H24332 complement(2103877..2105250) no similarity SAKL0H24354g 0 2105501 2107114 ON 8 H24354 complement(2105501..2107114) some similarities with uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p- Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) required for nuclear export of ribosomes SAKL0H24376g 1 2107702 2112291 ON 8 H24376 (2107702..2112291) similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 5'-3' exonuclease involved in mRNA decay evolutionarily conserved component of cytoplasmic processing (P) bodies plays a role in microtubule-mediated processes filamentous growth and ribosomal RNA maturation SAKL0H24398g 0 2112387 2113202 ON 8 H24398 complement(2112387..2113202) similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern SAKL0H24420g 1 2113284 2114624 ON 8 H24420 (2113284..2114624) similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Protein with a role in accurate meiotic and mitotic double-strand break repair phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents SAKL0H24442g 0 2114736 2117444 ON 8 H24442 complement(2114736..2117444) similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial transporter acts both as a glutamate uniporter and as an aspartate-glutamate exchanger involved in nitrogen metabolism ornithine synthesis and the malate-aspartate NADH shuttle SAKL0H24464g 0 2118553 2121405 ON 8 H24464 complement(2118553..2121405) similar to gnl|GLV|KLLA0E13497g Kluyveromyces lactis KLLA0E13497g and weakly similar to YPR022C uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF SAKL0H24486g 0 2121700 2122662 ON 8 H24486 complement(2121700..2122662) similar to uniprot|Q75AH9 Ashbya gossypii ADL052W EAF3 Chromatin modification-related protein EAF3 and some similarites with YPR023C uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor nonessential component of the NuA4 acetyltransferase complex homologous to Drosophila dosage compensation protein MSL3 SAKL0H24508g 1 2123140 2124606 ON 8 H24508 (2123140..2124606) uniprot|Q875P0 Saccharomyces kluyveri YCK3 and some similarities with YER123W uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 plasma membrane-bound casein kinase I homolog SAKL0H24530g 0 2127253 2128998 ON 8 H24530 complement(2127253..2128998) similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein may participate in pathways regulating cell wall metabolism deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall SAKL0H24552g 1 2129859 2132231 ON 8 H24552 (2129859..2132231) highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting contains a hect (homologous to E6-AP carboxyl terminus) domain SAKL0H24574g 1 2134361 2135917 ON 8 H24574 (2134361..2135917) weakly similar to uniprot|P46945 Saccharomyces cerevisiae YGL176C Hypothetical ORF SAKL0H24596g 0 2136702 2139014 ON 8 H24596 complement(2136702..2139014) similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components has roles in longevity in maintenance of cell wall integrity and in sensitivity to and recovery from pheromone arrest SAKL0H24618g 0 2140778 2141635 ON 8 H24618 complement(2140778..2141635) similar to uniprot|P38892 Saccharomyces cerevisiae YHR209W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family SAKL0H24640g 0 2142235 2143020 ON 8 H24640 complement(2142235..2143020) highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis SAKL0H24662g 1 2143299 2144348 ON 8 H24662 (2143299..2144348) similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA depletion leads to inhibited pre-rRNA processing and reduced polysome levels localizes primarily to the nucleolus SAKL0H24684g 1 2144483 2145100 ON 8 H24684 (2144483..2145100) similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Hypothetical ORF SAKL0H24706g 1 2145552 2149100 ON 8 H24706 (2145552..2149100) similar to uniprot|Q75CH2 Ashbya gossypii ACL053C ACL053Cp and weakly similar to YER129W uniprot|P38990 Saccharomyces cerevisiae YER129W PAK1 Upstream kinase for the SNF1 complex partially redundant function with Elm1p and Tos3p members of this family of kinases have functional orthology with LKB1 a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome SAKL0H24728g 1 2149968 2152154 ON 8 H24728 (2149968..2152154) weakly similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N- linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family SAKL0H24750g 0 2152673 2155420 ON 8 H24750 complement(2152673..2155420) similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway SAKL0H24772g 0 2155837 2157081 ON 8 H24772 complement(2155837..2157081) weakly similar to uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc-finger in the N- terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport SAKL0H24794g 1 2157080 2158043 ON 8 H24794 (2157080..2157115,2157369..2158043) similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division forms a complex with Hop2p which is involved in chromosome pairing and repair of meiotic double-strand breaks SAKL0H24816g 0 2158299 2159531 ON 8 H24816 complement(2158299..2159531) weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF SAKL0H24838g 1 2160460 2161692 ON 8 H24838 (2160460..2161692) conserved hypothetical protein SAKL0H24860g 0 2162455 2165370 ON 8 H24860 complement(2162455..2165370) conserved hypothetical protein SAKL0H24882g 1 2167623 2169002 ON 8 H24882 (2167623..2169002) highly similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine SAKL0H24904g 1 2169931 2171043 ON 8 H24904 (2169931..2171043) similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative hydroxyacid dehydrogenase SAKL0H24926g 1 2171636 2172688 ON 8 H24926 (2171636..2172688) similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases SAKL0H24948g 1 2173042 2174691 ON 8 H24948 (2173042..2174691) similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Pyridoxine transporter SAKL0H24970g 1 2175381 2175845 ON 8 H24970 (2175381..2175845) highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain N-terminal 25 residues of precursor are cleaved during mitochondrial import SAKL0H24992g 1 2177221 2177580 ON 8 H24992 (2177221..2177580) highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C SAKL0H25014g 1 2178085 2179431 ON 8 H25014 (2178085..2179431) highly similar to uniprot|Q753X7 Ashbya gossypii AFR195W AFR195Wp and similar to YGL190C uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A has multiple roles in mitosis and protein biosynthesis found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells) SAKL0H25036g 0 2179816 2180214 ON 8 H25036 complement(2179816..2180214) highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain not essential for cytochrome c oxidase activity but may modulate activity in response to ATP Sklu_8.trna50G 0 2180441 2180511 ON 8 tG-GCC complement(2180441..2180511) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 62.73 SAKL0H25102g 0 2181607 2183409 ON 8 H25102 complement(2181607..2183409) similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation expression is induced in starved MATa/MAT alpha diploid cells SAKL0H25124g 1 2184039 2185385 ON 8 H25124 (2184039..2185385) highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails subunit of the Set3 complex a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity SAKL0H25146g 0 2185695 2187632 ON 8 H25146 complement(2185695..2187632) similar to uniprot|Q754A1 Ashbya gossypii AFR171W AFR171Wp and some similarites with YDR034C uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer Sklu_YGOB_YGL194C-A 1 2187706 2188053 ON 8 YGL194C-A (2187706..2188053) ANNOTATED BY YGOB - SAKL0H25168g 0 2188094 2196112 ON 8 H25168 complement(2188094..2196112) similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA SAKL0H25190g 0 2196842 2198137 ON 8 H25190 complement(2196842..2198137) similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF SAKL0H25212g 0 2198913 2203907 ON 8 H25212 complement(2198913..2203907) similar to uniprot|P53094 Saccharomyces cerevisiae YGL197W MDS3 Protein with an N-terminal kelch-like domain putative negative regulator of early meiotic gene expression required with Pmd1p for growth under alkaline conditions SAKL0H25234g 0 2204474 2205127 ON 8 H25234 complement(2204474..2205127) weakly similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases computational analysis of large-scale protein- protein interaction data suggests a possible role in vesicle-mediated transport SAKL0H25278g 1 2205769 2207387 ON 8 H25278 (2205769..2205945,2206629..2207387) highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Catalytic subunit of type 1 serine/threonine protein phosphatase involved in many processes including glycogen metabolism sporulation and mitosis interacts with multiple regulatory subunits predominantly isolated with Sds22p SAKL0H25300g 1 2208615 2209223 ON 8 H25300 (2208615..2209223) highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport Sklu_8.trna51H 0 2209440 2209511 ON 8 tH-GUG complement(2209440..2209511) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 65.11 SAKL0H25344g 1 2209672 2212455 ON 8 H25344 (2209672..2212455) similar to gnl|GLV|KLLA0F18238g Kluyveromyces lactis KLLA0F18238g and weakly similar to YHL023C uniprot|P38742 Saccharomyces cerevisiae YHL023C RMD11 Protein required for sporulation SAKL0H25366g 0 2212946 2214826 ON 8 H25366 complement(2212946..2214826) weakly similar to uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes SAKL0H25388g 0 2217698 2220403 ON 8 H25388 complement(2217698..2220403) highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured aggregated proteins responsive to stresses including: heat ethanol and sodium arsenite involved in [PSI ] propagation SAKL0H25410g 0 2221083 2221763 ON 8 H25410 complement(2221083..2221763) conserved hypothetical protein SAKL0H25432g 0 2223045 2224715 ON 8 H25432 complement(2223045..2224715) conserved hypothetical protein SAKL0H25454g 0 2225251 2226075 ON 8 H25454 complement(2225251..2226075) similar to uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency depletion reduces growth on nonfermentable carbon sources SAKL0H25476g 0 2226440 2228710 ON 8 H25476 complement(2226440..2228710) similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W Hypothetical ORF SAKL0H25498g 0 2229233 2231041 ON 8 H25498 complement(2229233..2231041) similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification SAKL0H25520g 1 2233960 2236221 ON 8 H25520 (2233960..2236221) some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis SAKL0H25542g 1 2236849 2239890 ON 8 H25542 (2236849..2239890) similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C SAKL0H25564g 0 2240089 2240982 ON 8 H25564 complement(2240089..2240982) weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex SAKL0H25586g 1 2241255 2243381 ON 8 H25586 (2241255..2243381) weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Hypothetical ORF SAKL0H25608g 0 2243456 2244070 ON 8 H25608 complement(2243456..2244070) similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W SAKL0H25630g 1 2244348 2246840 ON 8 H25630 (2244348..2246840) highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family required for export of pre-ribosomal large subunits from the nucleus distributed between the nucleolus nucleoplasm and nuclear periphery depending on growth conditions SAKL0H25652g 0 2246901 2248947 ON 8 H25652 complement(2246901..2248822,2248938..2248947) similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Protein of unknown function required for cell growth and possibly involved in rRNA processing mRNA is cell cycle regulated SAKL0H25674g 0 2249157 2250503 ON 8 H25674 complement(2249157..2250503) weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W SAKL0H25696g 0 2250743 2252278 ON 8 H25696 complement(2250743..2252278) some similarities with uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 cell wall integrity and stress response component 4 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC3 SAKL0H25718g 1 2252716 2254365 ON 8 H25718 (2252716..2254365) similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts SAKL0H25740g 1 2254859 2256593 ON 8 H25740 (2254859..2254871,2254990..2256593) similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome contains a U-box a motif found in a class of ubiquitin ligases SAKL0H25762g 1 2256842 2257630 ON 8 H25762 (2256842..2257630) some similarities with uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function contains an N-terminal epsin-like domain SAKL0H25784g 1 2259314 2260231 ON 8 H25784 (2259314..2260231) highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039c UBI4 ubiquitin SAKL0H25806g 0 2260513 2266113 ON 8 H25806 complement(2260513..2266113) similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Major component of the proteasome tethers the proteasome core particle to the regulatory particle and enhances the stability of the proteasome SAKL0H25828g 1 2266152 2275637 ON 8 H25828 (2266152..2275637) similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 homologous to human COH1 component of peripheral vacuolar membrane protein complex SAKL0H25850g 1 2276005 2276793 ON 8 H25850 (2276005..2276793) highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone SAKL0H25872g 1 2277092 2277586 ON 8 H25872 (2277092..2277586) similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Enzyme that mediates formation of the Atg12p- Atg5p conjugate which is a critical step in autophagy SAKL0H25894g 1 2277655 2278299 ON 8 H25894 (2277655..2278299) similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport homolog of the mammalian protein GOS-28/GS28 SAKL0H25916g 0 2278823 2280844 ON 8 H25916 complement(2278823..2280844) similar to gnl|GLV|KLLA0E00550g Kluyveromyces lactis KLLA0E00550g and some similarites with YLL043W uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane glycerol channel member of the major intrinsic protein (MIP) family of channel proteins involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite SAKL0H25938g 1 2281415 2283472 ON 8 H25938 (2281415..2283472) similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase converts glycerol to glycerol- 3-phosphate glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p derepression of expression on non- fermentable carbon sources is mediated by Opi1p and Rsf1p SAKL0H25960g 1 2283904 2284674 ON 8 H25960 (2283904..2284674) highly similar to uniprot|P29453 Saccharomyces cerevisiae RPL8B and to YHL033C uniprot|P17076 Saccharomyces cerevisiae RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit SAKL0H25982g 1 2285232 2285816 ON 8 H25982 (2285232..2285816) weakly similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) SAKL0H26004g 1 2286392 2287333 ON 8 H26004 (2286392..2287333) similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C SBP1 Single-strand nucleic acid binding protein SAKL0H26026g 1 2287664 2292625 ON 8 H26026 (2287664..2292625) similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C SAKL0H26048g 0 2292824 2294482 ON 8 H26048 complement(2292824..2294482) similar to uniprot|P38734 YHL036W Saccharomyces cerevisiae MUP3 Low affinity methionine permease, similar to Mup1p SAKL0H26070g 1 2294909 2296843 ON 8 H26070 (2294909..2296843) weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Protein required for splicing of COB aI5 intron Cytochrome B pre-mRNA processing protein SAKL0H26092g 0 2296840 2297391 ON 8 H26092 complement(2296840..2297391) weakly similar to uniprot|Q07887 Saccharomyces cerevisiae YLL049W Hypothetical ORF SAKL0H26114g 1 2297559 2298064 ON 8 H26114 (2297559..2297572,2297647..2298064) highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 yeast cortical cytoskeleton component mammalian cofilin homolog Cofilin actin binding and severing protein SAKL0H26136g 1 2298332 2300047 ON 8 H26136 (2298332..2300047) conserved hypothetical protein SAKL0H26158g 0 2300170 2301876 ON 8 H26158 complement(2300170..2301876) similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF SAKL0H26180g 0 2302425 2303825 ON 8 H26180 complement(2302425..2303825) conserved hypothetical protein SAKL0H26202g 1 2304201 2306150 ON 8 H26202 (2304201..2306150) weakly similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases SAKL0H26224g 1 2308056 2308739 ON 8 H26224 (2308056..2308739) some similarities with uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids SAKL0H26246g 0 2311294 2312949 ON 8 H26246 complement(2311294..2312949) conserved hypothetical protein