KLLA0A00110g 1 2788 3834 ON 1 A00110 (2788..3834) conserved hypothetical protein KLLA0A00132g 1 4628 6151 ON 1 A00132 (4628..6151) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0A00143g 0 6838 7056 ON 1 A00143 complement(6838..7056) conserved hypothetical protein KLLA0A00154g 1 8139 8579 ON 1 A00154 (8139..8579) conserved hypothetical protein KLLA0A00176g 0 10102 11511 ON 1 A00176 complement(10102..11511) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin KLLA0A00198g 0 14237 15211 ON 1 A00198 complement(14237..15211) highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Protein required for thiamine biosynthesis and for mitochondrial genome stability KLLA0A00220g 1 17582 18067 ON 1 A00220 (17582..18067) some similarities with uniprot|Q2S3S7 Salinibacter ruber SRU_1022 Mitochondrial benzodiazepine receptor/sensory transduction protein KLLA0A00242g 0 18272 19105 ON 1 A00242 complement(18272..19105) similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads or uniprot|P32907 Saccharomyces cerevisiae YNR002c KLLA0A00264g 1 20634 21338 ON 1 A00264 (20634..21338) highly similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S- transferase capable of homodimerization expression induced during the diauxic shift and throughout stationary phase functional overlap with Gtt2p Grx1p and Grx2p KLLA0A00286g 0 22024 25698 ON 1 A00286 complement(22024..25698) similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells Klac_1.trna1G 1 26345 26444 ON 1 tG-UCC (26345..26382,26410..26444) tRNA Type: Gly (G) | Anti-Codon: UCC | Cove Score: 68.85 KLLA0A00352g 0 26582 27238 ON 1 A00352 complement(26582..27238) similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function nearly identical to Sno2p expression is induced before the diauxic shift and also in the absence of thiamin and uniprot|P53823 Saccharomyces cerevisiae YNL334C SNO2 and uniprot|Q03144 Saccharomyces cerevisiae YMR095C SNO1 KLLA0A00374g 1 28198 29091 ON 1 A00374 (28198..29091) highly similar to uniprot|P43545 Saccharomyces cerevisiae YFL059W SNZ3 Member of a stationary phase- induced gene family transcription of SNZ2 is induced prior to diauxic shift and also in the absence of thiamin in a Thi2p-dependent manner forms a coregulated gene pair with SNO3 and uniprot|P53824 Saccharomyces cerevisiae YNL333W SNZ2 and YMR096W uniprot|Q03148 Saccharomyces cerevisiae YMR096W SNZ1 KLLA0A00396g 1 29717 32755 ON 1 A00396 (29717..32755) similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W UBP7 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions KLLA0A00418g 0 33084 35012 ON 1 A00418 complement(33084..35012) similar to uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p Rsf1p Hap2/3/4/5 complex dependent manner KLLA0A00440g 0 37134 38201 ON 1 A00440 complement(37134..38201) similar to uniprot|Q753L8 Ashbya gossypii AFR294W AFR294Wp and weakly similar to YIL154C uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants contains a C-terminal leucine-rich repeat KLLA0A00462g 1 38766 39827 ON 1 A00462 (38766..39827) similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Resistant to Rapamycin Deletion KLLA0A00484g 0 40330 41961 ON 1 A00484 complement(40330..41961) highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase key enzyme in gluconeogenesis catalyzes early reaction in carbohydrate biosynthesis glucose represses transcription and accelerates mRNA degradation regulated by Mcm1p and Cat8p located in the cytosol KLLA0A00506g 1 43949 44488 ON 1 A00506 (43949..44488) no similarity KLLA0A00528g 0 44587 48276 ON 1 A00528 complement(44587..48276) similar to uniprot|P36168 Saccharomyces cerevisiae YKR096W KLLA0A00539g 0 49433 49774 ON 1 A00539 complement(49433..49661,49740..49774) highly similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Protein KLLA0A00550g 1 50099 51241 ON 1 A00550 (50099..51241) conserved hypothetical protein KLLA0A00572g 0 51265 53081 ON 1 A00572 complement(51265..52910,52994..53081) similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication KLLA0A00594g 0 53304 58550 ON 1 A00594 complement(53304..58550) similar to uniprot|Q02455 Saccharomyces cerevisiae YKR095W MLP1 Myosin-like protein associated with the nuclear envelope connects the nuclear pore complex with the nuclear interior involved in the Tel1p pathway that controls telomere length involved in the retention of unspliced mRNAs in the nucleus KLLA0A00616g 1 59180 60105 ON 1 A00616 (59180..59187,59727..60105) highly similar to uniprot|P04838 Saccharomyces cerevisiae YKR094C RPL40B Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes KLLA0A00638g 0 60378 63845 ON 1 A00638 complement(60378..63845) similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators KLLA0A00660g 0 64397 65971 ON 1 A00660 complement(64397..65971) weakly similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ECM37 Non-essential protein of unknown function KLLA0A00682g 1 67685 69811 ON 1 A00682 (67685..69811) highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS) forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm KLLA0A00715g 0 69861 71636 ON 1 A00715 complement(69861..71636) weakly similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation KLLA0A00737g 1 72233 73981 ON 1 A00737 (72233..73981) similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex directly or indirectly regulates DNA-binding properties of Spt15p (TATA box-binding protein) and relative activities of different TATA elements KLLA0A00759g 1 74187 75329 ON 1 A00759 (74187..75329) similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase deaminates adenosine-37 to inosine in tRNA-Ala KLLA0A00781g 0 75435 75950 ON 1 A00781 complement(75435..75950) similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Hypothetical ORF KLLA0A00803g 1 76350 79208 ON 1 A00803 (76350..79208) similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W KAP114 Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear KLLA0A00825g 1 79588 80595 ON 1 A00825 (79588..80595) no similarity KLLA0A00847g 1 80886 81668 ON 1 A00847 (80886..81668) weakly similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC) mediates the activity of the APC by contributing to substrate recognition involved in cyclin proteolysis KLLA0A00869g 1 81975 84857 ON 1 A00869 (81975..84857) highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p) homolog of metazoan CAS protein required for accurate chromosome segregation KLLA0A00891g 0 85013 85915 ON 1 A00891 complement(85013..85915) uniprot|P53768 Kluyveromyces lactis KLLA0A00891g HAP2 Transcriptional activator HAP2 KLLA0A00913g 1 86295 87059 ON 1 A00913 (86295..87059) conserved hypothetical protein KLLA0A00935g 0 87118 89178 ON 1 A00935 complement(87118..89178) similar to uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis KLLA0A00957g 1 89999 92377 ON 1 A00957 (89999..92377) uniprot|Q9HG45 Kluyveromyces lactis Purine biosynthetic pathway protein ADE5,7 KLLA0A00979g 0 92561 93592 ON 1 A00979 complement(92561..93592) some similarities with uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family KLLA0A01001g 1 94392 95993 ON 1 A01001 (94392..95993) highly similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C KLLA0A01023g 1 96383 98968 ON 1 A01023 (96383..98968) similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which mediates polarized targeting of vesicles to active sites of exocytosis Sec15p associates with Sec4p and vesicles KLLA0A01045g 1 99292 100221 ON 1 A01045 (99292..100221) similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA KLLA0A01067g 0 100259 100867 ON 1 A01067 complement(100259..100867) similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C KLLA0A01089g 1 102036 102737 ON 1 A01089 (102036..102737) weakly similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C KLLA0A01111g 0 102802 103431 ON 1 A01111 complement(102802..103431) similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W Protein required for cell viability KLLA0A01133g 1 103746 104579 ON 1 A01133 (103746..104579) similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Endoplasmic reticulum protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain KLLA0A01155g 0 104687 107668 ON 1 A01155 complement(104687..107668) similar to uniprot|P43612 Saccharomyces cerevisiae YFR040W KLLA0A01177g 1 108738 110648 ON 1 A01177 (108738..110648) weakly similar to uniprot|P53075 Saccharomyces cerevisiae YGL228W SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function overexpression causes growth arrest KLLA0A01199g 1 111159 112508 ON 1 A01199 (111159..112508) highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S- adenosyl-L-methionine (AdoMet) to an acceptor KLLA0A01221g 1 113308 115926 ON 1 A01221 (113308..115926) weakly similar to uniprot|P53076 Saccharomyces cerevisiae YGL227W KLLA0A01287g 0 115966 116340 ON 1 A01287 complement(115966..116235,116320..116340) similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins KLLA0A01297g 1 116612 117037 ON 1 A01297 (116612..117037) similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W KLLA0A01309g 0 117215 117769 ON 1 A01309 complement(117215..117769) highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Peptide methionine sulfoxide reductase reverses the oxidation of methionine residues involved in oxidative damage repair providing resistance to oxidative stress and regulation of lifespan KLLA0A01320g 0 118369 120123 ON 1 A01320 complement(118369..120123) weakly similar to uniprot|P40028 Saccharomyces cerevisiae YER041W YEN1 Protein of unknown function has similarity to endonuclease Rth1p potentially phosphorylated by Cdc28p KLLA0A01342g 0 120385 122730 ON 1 A01342 complement(120385..122730) some similarities with uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR) localization and activity regulated by quality of nitrogen source KLLA0A01364g 1 124161 125153 ON 1 A01364 (124161..125153) similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W VRG4 May regulate Golgi function and glycosylation in Golgi Golgi GDP-mannose transporter KLLA0A01386g 1 125585 126721 ON 1 A01386 (125585..126721) weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance KLLA0A01408g 0 126900 127760 ON 1 A01408 complement(126900..127760) similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C SDT1 Pyrimidine nucleotidase overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II as well as resistance to other pyrimidine derivatives and to uniprot|P40025 Saccharomyces cerevisiae YER037W PHM8 KLLA0A01430g 0 128139 129287 ON 1 A01430 complement(128139..129287) weakly similar to uniprot|P53079 Saccharomyces cerevisiae YGL223C COG1 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments KLLA0A01452g 1 130078 131901 ON 1 A01452 (130078..131901) highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C KLLA0A01474g 0 132423 133565 ON 1 A01474 complement(132423..133565) some similarities with uniprot|P53080 Saccharomyces cerevisiae YGL222C EDC1 RNA-binding protein activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p KLLA0A01496g 0 134214 134804 ON 1 A01496 complement(134214..134804) some similarities with uniprot|P40022 Saccharomyces cerevisiae YER034W KLLA0A01518g 0 135063 135920 ON 1 A01518 complement(135063..135920) similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C KLLA0A01551g 1 136238 136495 ON 1 A01551 (136238..136495) similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W KLLA0A01573g 0 136823 138445 ON 1 A01573 complement(136823..138445) similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial outer membrane protein colocalizes with mtDNA nucleids required for mitochondria shape KLLA0A01606g 1 139355 141664 ON 1 A01606 (139355..141664) similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning KLLA0A01628g 1 143922 145160 ON 1 A01628 (143922..145160) weakly similar to uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 cyclin-like protein that interacts with Pho85p in affinity chromatography cyclin-like protein that interacts with Pho85 KLLA0A01650g 0 146030 147235 ON 1 A01650 complement(146030..147235) similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 essential for protection against viral cytopathology dispensable for mitotic but required for meiotic recombination and spore viability antiviral protein mRNA is induced early in meiosis KLLA0A01672g 1 147876 148916 ON 1 A01672 (147876..148916) similar to uniprot|Q755T0 Ashbya gossypii AER438C AER438Cp and weakly similar to YGL212W uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Regulator of vacuolar morphogenesis hydrophilic protein heptad repeat motif KLLA0A01694g 0 149587 151293 ON 1 A01694 complement(149587..151293) weakly similar to uniprot|P25346 YCR098C Saccharomyces cerevisiae GIT1 Plasma membrane permease, mediates uptake of the phosphatidylinositol metabolite glycerophosphoinositol KLLA0A01738g 0 152383 153498 ON 1 A01738 complement(152383..153498) highly similar to uniprot|P25087 Saccharomyces cerevisiae YML008C ERG6 Delta(24)-sterol C- methyltransferase KLLA0A01760g 1 154859 156610 ON 1 A01760 (154859..156610) uniprot|P56095 Kluyveromyces lactis KLLA0A01760g YAP1 AP- 1-like transcription factor KLLA0A01782g 0 157216 158802 ON 1 A01782 complement(157216..158802) some similarities with uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function proposed to be involved in the RAS/cAMP signaling pathway KLLA0A01804g 0 159689 162526 ON 1 A01804 complement(159689..162526) similar to uniprot|Q04052 Saccharomyces cerevisiae YDR421W ARO80 Zinc finger transcriptional activator of the Zn2Cys6 family activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids KLLA0A01826g 0 163010 167404 ON 1 A01826 complement(163010..167404) some similarities with uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Serine/threonine rich cell surface protein that contains an EF hand motif involved in the regulation of cell wall beta-1 3 glucan synthesis and bud site selection overexpression confers resistance to Hansenula mrakii killer toxin HM-1 KLLA0A01848g 0 167886 169823 ON 1 A01848 complement(167886..169823) similar to uniprot|Q04049 YDR419W Saccharomyces cerevisiae RAD30 DNA polymerase eta involved in the predominantly error-free bypass replication of DNA lesions KLLA0A01870g 0 170104 170985 ON 1 A01870 complement(170104..170985) conserved hypothetical protein KLLA0A01903g 0 172232 172729 ON 1 A01903 complement(172232..172729) highly similar to uniprot|P17079 YEL054C Saccharomyces cerevisiae RPL12A or uniprot|P17079 Saccharomyces cerevisiae YDR418w RPL12A Protein component of the large (60S) ribosomal subunit KLLA0A01925g 0 173617 175977 ON 1 A01925 complement(173617..175977) similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type KLLA0A01947g 1 176815 178338 ON 1 A01947 (176815..178338) similar to uniprot|P32317 YEL052W Saccharomyces cerevisiae AFG1 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to mitochondria KLLA0A01969g 0 178458 180854 ON 1 A01969 complement(178458..180854) similar to uniprot|Q04048 Saccharomyces cerevisiae YDR416w SYF1 synthetic lethal with CDC40 KLLA0A01991g 1 181274 182104 ON 1 A01991 (181274..182104) highly similar to uniprot|P32610 YEL051W Saccharomyces cerevisiae VMA8 vacuolar ATPase V1 domain subunit D KLLA0A02013g 1 182326 183447 ON 1 A02013 (182326..183447) similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C KLLA0A02035g 0 183620 184825 ON 1 A02035 complement(183620..184825) similar to uniprot|P32611 YEL050C Saccharomyces cerevisiae RML2 Mitochondrial ribosomal protein of the large subunit KLLA0A02057g 1 186220 187374 ON 1 A02057 (186220..187374) uniprot|P41771 Kluyveromyces lactis KLLA0A02057g ERD1 Protein ERD1 KLLA0A02079g 0 187421 188152 ON 1 A02079 complement(187421..188152) similar to uniprot|Q04031 YDR412W Saccharomyces cerevisiae RRP17 Protein required for cell viability KLLA0A02101g 1 188671 189519 ON 1 A02101 (188671..189519) similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1 KLLA0A02123g 1 190132 192165 ON 1 A02123 (190132..192165) similar to uniprot|P32796 YML042W Saccharomyces cerevisiae CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes KLLA0A02145g 1 192493 193242 ON 1 A02145 (192493..193242) similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting KLLA0A02167g 1 193623 194369 ON 1 A02167 (193623..194369) similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum localizes to the ER membrane KLLA0A02189g 0 194500 196848 ON 1 A02189 complement(194500..196848) some similarities with uniprot|Q04195 YDR409W Saccharomyces cerevisiae SIZ1 SUMO ligase that promotes the attachment of sumo (Smt3p small ubiquitin-related modifier) to proteins KLLA0A02211g 1 197863 198510 ON 1 A02211 (197863..198510) similar to uniprot|P04161 YDR408C Saccharomyces cerevisiae ADE8 Phosphoribosyl-glycinamide transformylase KLLA0A02233g 0 198766 199554 ON 1 A02233 complement(198766..199554) highly similar to uniprot|P25043 YOR157C Saccharomyces cerevisiae PUP1 Endopeptidase with trypsin- like activity that cleaves after basic residues KLLA0A02255g 1 199863 203495 ON 1 A02255 (199863..203495) similar to uniprot|Q04183 YDR407C Saccharomyces cerevisiae TRS120 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic KLLA0A02277g 1 203818 204732 ON 1 A02277 (203818..204732) similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit PET123 exhibits genetic interactions with PET122 which encodes a COX3 mRNA-specific translational activator KLLA0A02299g 0 205013 205294 ON 1 A02299 complement(205013..205294) similar to uniprot|Q12330 YOR159C Saccharomyces cerevisiae SME1 Required for pre-mRNA splicing, cap modification and U1 U2 U4 and U5 snRNA stability KLLA0A02321g 1 205567 208452 ON 1 A02321 (205567..208452) similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor mediates the nuclear localization of proteins involved in mRNA-nucleus export KLLA0A02343g 0 208673 210334 ON 1 A02343 complement(208673..210334) similar to uniprot|Q12412 YOR161C Saccharomyces cerevisiae PNS1 KLLA0A02365g 1 211300 212568 ON 1 A02365 (211300..212568) similar to uniprot|Q99312 YOR155C Saccharomyces cerevisiae ISN1 Inosine 5'-monophosphate (IMP)-specific 5'- nucleotidase KLLA0A02387g 1 213276 213779 ON 1 A02387 (213276..213779) no similarity Klac_1.trna2S 0 214096 214177 ON 1 tS-AGA complement(214096..214177) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 KLLA0A02431g 0 214580 215095 ON 1 A02431 complement(214580..215095) weakly similar to uniprot|Q2ZX20 Shewanella putrefaciens CN-32 Sputcn32DRAFT_3504 Hypothetical protein KLLA0A02453g 0 215305 216177 ON 1 A02453 complement(215305..216177) similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C KLLA0A02475g 0 216566 217687 ON 1 A02475 complement(216566..217687) similar to uniprot|Q9HGY3 Candida boidinii DAO1 D- amino acid oxidase KLLA0A02497g 1 218592 219680 ON 1 A02497 (218592..219680) highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response KLLA0A02519g 1 220146 222500 ON 1 A02519 (220146..222500) similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W KLLA0A02541g 1 223318 224913 ON 1 A02541 (223318..224913) some similarities with uniprot|P41698 Saccharomyces cerevisiae YLR353W BUD8 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern and bud at the proximal pole KLLA0A02563g 1 225343 226095 ON 1 A02563 (225343..226095) similar to uniprot|Q75CW0 Ashbya gossypii ACL194C ACL194Cp and some similarites with YGR042W uniprot|P53227 Saccharomyces cerevisiae YGR042W KLLA0A02585g 0 226562 227674 ON 1 A02585 complement(226562..227674) conserved hypothetical protein KLLA0A02607g 0 231111 232115 ON 1 A02607 complement(231111..232115) highly similar to uniprot|P15019 Saccharomyces cerevisiae YLR354C TAL1 Transaldolase enzyme in the pentose phosphate pathway KLLA0A02629g 0 233822 235501 ON 1 A02629 complement(233822..235501) some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator KLLA0A02651g 0 238735 239409 ON 1 A02651 complement(238735..239409) similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress KLLA0A02673g 0 240153 241346 ON 1 A02673 complement(240153..241346) highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Acetohydroxyacid reductoisomerase mitochondrial protein involved in branched-chain amino acid biosynthesis also required for maintenance of wild- type mitochondrial DNA KLLA0A02695g 1 242521 243228 ON 1 A02695 (242521..243228) weakly similar to uniprot|Q06485 Saccharomyces cerevisiae YLR356W KLLA0A02717g 1 245082 246380 ON 1 A02717 (245082..246380) weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 The authentic non-tagged protein was localized to the mitochondria KLLA0A02739g 0 246644 247255 ON 1 A02739 complement(246644..247255) some similarities with uniprot|Q45U33 Saccharomyces cerevisiae YGR053c KLLA0A02761g 1 247871 249628 ON 1 A02761 (247871..249628) similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W yeast homolog of mammalian eIF2A Klac_1.trna3Q 0 249870 249975 ON 1 tQ-CUG complement(249870..249904,249939..249975) tRNA Type: Gln (Q) | Anti-Codon: CUG | Cove Score: 58.73 KLLA0A02827g 1 250872 252191 ON 1 A02827 (250872..252191) highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability KLLA0A02849g 0 252275 253204 ON 1 A02849 complement(252275..253204) weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function KLLA0A02871g 0 253619 255511 ON 1 A02871 complement(253619..255511) conserved hypothetical protein KLLA0A02893g 1 256320 258233 ON 1 A02893 (256320..258233) conserved hypothetical protein KLLA0A02915g 0 258504 259265 ON 1 A02915 complement(258504..259265) similar to uniprot|Q758P2 Ashbya gossypii AEL289W AEL289Wp and weakly similar to YKR006C uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation KLLA0A02937g 1 259865 260296 ON 1 A02937 (259865..260296) some similarities with uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1 KLLA0A02959g 1 260627 262306 ON 1 A02959 (260627..262306) similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex found in close proximity to nucleosomal DNA displaced from the surface of nucleosomal DNA after chromatin remodeling KLLA0A02981g 0 262440 264356 ON 1 A02981 complement(262440..264356) weakly similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex maintains cohesion between sister chromatids during meiosis I maintains cohesion between centromeres of sister chromatids until meiosis II homolog of S. pombe Rec8p KLLA0A03003g 1 264785 265393 ON 1 A03003 (264785..265393) weakly similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far8p Far9p Far10p and Far11p KLLA0A03025g 1 266917 268077 ON 1 A03025 (266917..268077) similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane forms complex with Fet3p expression is regulated by iron KLLA0A03047g 1 269553 271256 ON 1 A03047 (269553..271256) similar to uniprot|Q758P8 Ashbya gossypii AEL295C AEL295Cp and some similarites with YPR008W uniprot|Q12753 Saccharomyces cerevisiae KLLA0A03069g 0 271516 274203 ON 1 A03069 complement(271516..274203) highly similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis member of the SWI/SNF family KLLA0A03091g 1 276333 277484 ON 1 A03091 (276333..277484) some similarities with uniprot|Q12286 Saccharomyces cerevisiae YPR009W SUT2 Involved in sterol uptake homologous to SUT1 KLLA0A03113g 0 277880 278677 ON 1 A03113 complement(277880..278677) weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases computational analysis of large-scale protein- protein interaction data suggests a possible role in vesicle-mediated transport KLLA0A03135g 1 279951 281165 ON 1 A03135 (279951..281165) similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Protein required for respiratory growth null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start KLLA0A03157g 0 281313 284129 ON 1 A03157 complement(281313..284129) uniprot|O74296 Kluyveromyces lactis KlPMR1 Ca++ ATPase KLLA0A03179g 0 285228 286244 ON 1 A03179 complement(285228..286244) weakly similar to uniprot|P36027 Saccharomyces cerevisiae YLR332W MID2 Protein required for mating KLLA0A03201g 0 287031 288167 ON 1 A03201 complement(287031..288167) some similarities with uniprot|Q04951 Saccharomyces cerevisiae YMR305C KLLA0A03223g 1 290002 292035 ON 1 A03223 (290002..292035) similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock KLLA0A03245g 0 292179 293015 ON 1 A03245 complement(292179..293015) highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7- methylguanosine modification of tRNA KLLA0A03267g 0 293329 294066 ON 1 A03267 complement(293329..294066) similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit KLLA0A03289g 0 294825 295898 ON 1 A03289 complement(294825..295898) weakly similar to uniprot|P47177 Saccharomyces cerevisiae YJR149W KLLA0A03311g 1 296290 297294 ON 1 A03311 (296290..297294) uniprot|O60012 Kluyveromyces lactis Putative sulfate transporter KLLA0A03333g 0 297542 299665 ON 1 A03333 complement(297542..299665) highly similar to uniprot|Q01574 Saccharomyces cerevisiae YAL054C ACS1 Acetyl-coA synthetase isoform expressed during growth on nonfermentable carbon sources and under aerobic conditions KLLA0A03355g 1 301465 303819 ON 1 A03355 (301465..303819) similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0A03377g 0 304117 304863 ON 1 A03377 complement(304117..304863) similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C KLLA0A03399g 1 305616 308153 ON 1 A03399 (305616..308153) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis KLLA0A03421g 1 308414 311056 ON 1 A03421 (308414..311056) weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis KLLA0A03443g 1 311628 314555 ON 1 A03443 (311628..314555) similar to uniprot|Q758X5 Ashbya gossypii ADR403C ADR403Cp and weakly similar to YAL051W uniprot|P39720 Saccharomyces cerevisiae YAL051W OAF1 Oleate-activated transcription factor acts alone and as a heterodimer with Pip2p activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis KLLA0A03465g 0 314573 316552 ON 1 A03465 complement(314573..316552) highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail- anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology cells lacking Gem1p contain collapsed globular or grape-like mitochondria not required for pheromone-induced cell death KLLA0A03487g 1 316951 317940 ON 1 A03487 (316951..316953,317116..317940) similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 20S proteasome alpha-type subunit KLLA0A03509g 0 318067 320397 ON 1 A03509 complement(318067..320397) weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex binds spindle pole bodies and links them to microtubules has roles in astral microtubule formation and stabilization KLLA0A03531g 1 320828 323026 ON 1 A03531 (320828..323026) similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes KLLA0A03553g 0 323382 323657 ON 1 A03553 complement(323382..323657) similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C KLLA0A03575g 1 323999 324361 ON 1 A03575 (323999..324361) similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Similar to pombe uvi31 putative DNA repair protein KLLA0A03597g 0 324491 325018 ON 1 A03597 complement(324491..325018) similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm KLLA0A03619g 1 326530 328080 ON 1 A03619 (326530..328080) similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase component of the cAMP-dependent protein kinase signaling system protects the cell from extracellular cAMP contains readthrough motif surrounding termination codon KLLA0A03641g 0 328807 330186 ON 1 A03641 complement(328807..330186) some similarities with uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1 KLLA0A03663g 0 331039 333513 ON 1 A03663 complement(331039..333513) similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF a multiprotein complex and functional homolog of mammalian CPSF required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends involved in pre-tRNA processing binds to the phosphorylated CTD of RNAPII KLLA0A03696g 0 334065 334535 ON 1 A03696 complement(334065..334535) highly similar to uniprot|Q758Y6 Ashbya gossypii ADR391W ADR391Wp and some similarites with uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme- activated glucose-repressed Hap2/3/4/5 CCAAT-binding complex a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex KLLA0A03718g 1 334828 335322 ON 1 A03718 (334828..335322) similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C KLLA0A03740g 0 335548 337287 ON 1 A03740 complement(335548..337287) similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter Klac_1.trna4I 1 337927 338000 ON 1 tI-AAU (337927..338000) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 Klac_1.trna5G 1 338524 338594 ON 1 tG-GCC (338524..338594) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0A03806g 0 338807 340615 ON 1 A03806 complement(338807..340615) highly similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 Protein serine/threonine kinase required for release from glucose repression invertase expression sporulation and for expression of catabolite- repressed genes when glucose is limiting regulates Adr1p- dependent transcription primarily at the level of chromatin binding KLLA0A03883g 1 344642 345098 ON 1 A03883 (344642..344725,344850..345098) highly similar to uniprot|P33328 Saccharomyces cerevisiae YOR327C SNC2 mediate the targeting and transport of secretory proteins vesicle-associated membrane protein (synaptobrevin) homolog KLLA0A03905g 0 345818 350470 ON 1 A03905 complement(345818..350470) similar to uniprot|P19524 Saccharomyces cerevisiae YOR326W MYO2 One of two type V myosins involved in polarized distribution of mitochondria required for mitochondrion and vacuole inheritance and nuclear spindle orientation moves multiple cargo KLLA0A03938g 1 351240 352502 ON 1 A03938 (351240..352502) some similarities with uniprot|P39734 Saccharomyces cerevisiae YAL028W FRT2 Tail-anchored endoplasmic reticulum membrane protein KLLA0A03960g 1 352856 353796 ON 1 A03960 (352856..352866,352938..353796) similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W KLLA0A03982g 1 354208 355551 ON 1 A03982 (354208..355551) highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase catalyzes the second step in proline biosynthesis KLLA0A04015g 0 355624 359655 ON 1 A04015 complement(355624..359655) highly similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Integral membrane Ca(2 )-ATPase potential aminophospholipid translocase required to form a specific class of secretory vesicles that accumulate upon actin cytoskeleton disruption mutation affects maturation of the 18S rRNA KLLA0A04037g 0 359981 360889 ON 1 A04037 complement(359981..360889) some similarities with uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein required for normal concentration of free 60S ribosomal subunits required for maintenance of M1 satellite double- stranded RNA of the L-A virus KLLA0A04059g 0 361328 365428 ON 1 A04059 complement(361328..365428) similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Putative GDP/GTP exchange factor required for mitotic exit at low temperatures acts as a guanine nucleotide exchange factor (GEF) for Tem1p which is a key regulator of mitotic exit physically associates with Ras2p- GTP KLLA0A04081g 1 366969 368552 ON 1 A04081 (366969..368552) conserved hypothetical protein KLLA0A04103g 1 369258 371615 ON 1 A04103 (369258..371615) similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C KLLA0A04125g 1 372826 374589 ON 1 A04125 (372826..374589) conserved hypothetical protein KLLA0A04147g 0 374897 375985 ON 1 A04147 complement(374897..375985) similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Activator of Heat Shock Protein 90 ATPase KLLA0A04169g 0 376273 378600 ON 1 A04169 complement(376273..378600) similar to uniprot|Q05958 Saccharomyces cerevisiae YLR228C ECM22 Sterol regulatory element binding protein regulates transcription of the sterol biosynthetic genes ERG2 and ERG3 member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors homologous to Upc2p KLLA0A04191g 0 379492 381171 ON 1 A04191 complement(379492..381171) highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 tailless complex polypeptide 1 chaperonin subunit alpha KLLA0A04213g 0 382243 382818 ON 1 A04213 complement(382243..382818) highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase essential for establishment and maintenance of cell polarity mutants have defects in the organization of actin and septin KLLA0A04235g 0 383275 385485 ON 1 A04235 complement(383275..385485) similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression Klac_1.trna6I 0 385847 385985 ON 1 tI-UAU complement(385847..385882,385948..385985) tRNA Type: Ile (I) | Anti-Codon: UAU | Cove Score: 70.75 Klac_YGOB_Anc_8.419 0 386183 386344 ON 1 Anc_8.419 complement(386183..386344) ANNOTATED BY YGOB - KLLA0A04301g 0 387006 389165 ON 1 A04301 complement(387006..389165) similar to uniprot|Q750P3 Ashbya gossypii AGL096W AGL096Wp and weakly similar to YDR208W uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol- 4-phosphate 5-kinase involved in actin cytoskeleton organization and cell morphogenesis multicopy suppressor of stt4 mutation KLLA0A04323g 1 391590 392201 ON 1 A04323 (391590..392201) some similarities with uniprot|Q04433 Saccharomyces cerevisiae YDR534C FIT1 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore- iron in the cell wall KLLA0A04345g 1 394997 395902 ON 1 A04345 (394997..395902) some similarities with uniprot|Q04433 Saccharomyces cerevisiae YDR534C FIT1 Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore- iron in the cell wall KLLA0A04367g 0 397648 398133 ON 1 A04367 complement(397648..398133) similar to uniprot|Q08906 Saccharomyces cerevisiae YOR382W FIT2 Mannoprotein KLLA0A04389g 1 400113 400775 ON 1 A04389 (400113..400775) weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W KLLA0A04411g 0 400945 401796 ON 1 A04411 complement(400945..401796) similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C KLLA0A04433g 0 402462 403532 ON 1 A04433 complement(402462..403532) highly similar to uniprot|Q74ZF9 Ashbya gossypii AGR292C AGR292Cp and similar to YLR291C uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression KLLA0A04499g 0 404732 405376 ON 1 A04499 complement(404732..405376) highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability KLLA0A04521g 0 405802 406581 ON 1 A04521 complement(405802..406581) conserved hypothetical protein KLLA0A04543g 0 406920 407249 ON 1 A04543 complement(406920..407249) similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis KLLA0A04565g 0 407581 408150 ON 1 A04565 complement(407581..408150) weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre- mRNA splicing KLLA0A04587g 1 408699 409991 ON 1 A04587 (408699..409991) highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans KLLA0A04609g 0 411494 412765 ON 1 A04609 complement(411494..412765) weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C KLLA0A04620g 0 413642 413914 ON 1 A04620 complement(413642..413914) no similarity KLLA0A04631g 0 415070 416809 ON 1 A04631 complement(415070..416809) weakly similar to uniprot|Q04602 Saccharomyces cerevisiae YDR119W Uncharacterized transporter KLLA0A04653g 0 417313 419415 ON 1 A04653 complement(417313..419415) similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein of unknown function contains WD repeats interacts with Mpp10p and Bfr2p and has homology to Spb1p Klac_1.trna7R 1 420025 420096 ON 1 tR-UCU (420025..420096) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 64.75 KLLA0A04708g 0 420317 421372 ON 1 A04708 complement(420317..421372) highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Cytoplasmic GTP binding protein functions as a negative regulator of the Ran/Tc4 GTPase cycle downstream of its binding partner and homolog Gtr1p homolog of human RagC and RagD proteins KLLA0A04730g 0 421863 424928 ON 1 A04730 complement(421863..424928) some similarities with uniprot|P39935 Saccharomyces cerevisiae YGR162W TIF4631 also called eIF4 (eIF-4) gamma mRNA cap-binding protein (eIF-4F) 150K subunit highly homologous to Tif4632p homologs of mammalian p220 KLLA0A04752g 0 425610 426824 ON 1 A04752 complement(425610..426824) highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates KLLA0A04774g 1 427263 427856 ON 1 A04774 (427263..427856) similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W KLLA0A04796g 0 427861 428502 ON 1 A04796 complement(427861..428502) similar to uniprot|Q754R6 Ashbya gossypii AFR006C AFR006Cp and weakly similar to YGL020C uniprot|P53192 Saccharomyces cerevisiae YGL020C MDM39 Protein involved in determination of mitochondrial structure KLLA0A04818g 1 429275 430108 ON 1 A04818 (429275..430108) similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 beta (38kDa) subunit of protein kinase CK2 KLLA0A04840g 0 430541 431113 ON 1 A04840 complement(430541..431113) similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Molecular chaperone involved with partner Ssq1p in assembly of Fe/S clusters and in mitochondrial iron metabolism contains a J domain typical to J-type chaperones localizes to the mitochondrial matrix KLLA0A04862g 1 431710 433221 ON 1 A04862 (431710..433221) similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway KLLA0A04884g 1 433581 436760 ON 1 A04884 (433581..436760) similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta responsible for import of the Toa1p-Toa2p complex into the nucleus binds to nucleoporins Nup1p and Nup2p may play a role in regulation of pleiotropic drug resistance KLLA0A04906g 1 437523 438965 ON 1 A04906 (437523..438965) similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis KLLA0A04928g 1 439349 441934 ON 1 A04928 (439349..441934) similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes contributes to nucleosome formation heterochromatic gene silencing and formation of functional kinetochores KLLA0A04961g 1 442461 444818 ON 1 A04961 (442461..444818) highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase catalyzes the second step in the leucine biosynthesis pathway KLLA0A04983g 0 445032 448787 ON 1 A04983 complement(445032..448787) similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton contains 3 SH3 domains interacts with proteins regulating actin dynamics and with proteins required for endocytosis KLLA0A05005g 0 449590 450111 ON 1 A05005 complement(449590..450111) similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W KLLA0A05027g 1 450398 451138 ON 1 A05027 (450398..451138) highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7) KLLA0A05049g 0 451480 451926 ON 1 A05049 complement(451480..451926) weakly similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Protein of unknown function null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface KLLA0A05071g 0 452333 453730 ON 1 A05071 complement(452333..453730) similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase catalyzes the final step in ergosterol biosynthesis mutants are viable but lack ergosterol KLLA0A05093g 1 454423 455211 ON 1 A05093 (454423..455211) highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit zeta KLLA0A05115g 0 455456 457006 ON 1 A05115 complement(455456..457006) highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Histone acetyltransferase acetylates lysine 14 on histone H3 catalytic subunit of the ADA and SAGA histone acetyltransferase complexes founding member of the Gcn5p-related N-acetyltransferase superfamily KLLA0A05137g 0 457440 459251 ON 1 A05137 complement(457440..459251) similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein that is a member of the E1 family of ubiquitin-activating enzymes mediates the conjugation of Atg12p with Atg5p a required step in the formation of autophagosomes KLLA0A05159g 0 459573 461117 ON 1 A05159 complement(459573..461117) similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex KLLA0A05181g 0 461373 461966 ON 1 A05181 complement(461373..461966) similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Protein required for cell viability KLLA0A05203g 0 462167 463474 ON 1 A05203 complement(462167..463474) highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit KLLA0A05225g 0 463760 465448 ON 1 A05225 complement(463760..465448) similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase member of the Obg family peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit required for mitochondrial translation possibly via a role in ribosome assembly KLLA0A05247g 0 465702 466481 ON 1 A05247 complement(465702..466481) some similarities with uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 affects transcription elongation KLLA0A05258g 1 466776 468674 ON 1 A05258 (466776..468674) similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition KLLA0A05280g 1 469130 476365 ON 1 A05280 (469130..476365) highly similar to uniprot|P33334 Saccharomyces cerevisiae YHR165C PRP8 Component of the U4/U6-U5 snRNP complex involved in the second catalytic step of splicing KLLA0A05302g 1 476757 477878 ON 1 A05302 (476757..477878) no similarity KLLA0A05324g 1 478337 482674 ON 1 A05324 (478337..482674) weakly similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase ATP-dependent nuclease and helicase activities required for Okazaki fragment processing involved in DNA repair pathways potential Cdc28p substrate KLLA0A05346g 1 485886 488510 ON 1 A05346 (485886..488510) some similarities with uniprot|P53316 Saccharomyces cerevisiae YGR250C KLLA0A05368g 0 490032 491270 ON 1 A05368 complement(490032..491270) weakly similar to uniprot|P53050 Saccharomyces cerevisiae YGR249W KLLA0A05390g 0 495847 496617 ON 1 A05390 complement(495847..496617) similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W SOL3 Glucose-6-phosphate dehydrogenase weak multicopy suppressor of los1-1 mutation homologous to Sol2p and Sol1p KLLA0A05412g 0 496866 497507 ON 1 A05412 complement(496866..497507) similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase hydrolyzes ADP-ribose 1'' 2''-cyclic phosphate to ADP- ribose 1''-phosphate no detectable phenotype is conferred by null mutation or by overexpression KLLA0A05434g 1 497874 499544 ON 1 A05434 (497874..499544) similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor one of three subunits of RNA polymerase III transcription initiation factor TFIIIB binds TFIIIC and TBP and recruits RNA pol III to promoters amino-terminal half is homologous to TFIIB KLLA0A05456g 1 500097 502376 ON 1 A05456 (500097..502376) highly similar to gnl|GLV|CAGL0F08129g Candida glabrata CAGL0F08129g and similar to YGR245C uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Severe Depolymerization of Actin KLLA0A05478g 1 503729 504997 ON 1 A05478 (503729..504997) highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate KLLA0A05500g 0 505579 505989 ON 1 A05500 complement(505579..505989) similar to uniprot|P53311 Saccharomyces cerevisiae YGR243W FMP43 KLLA0A05511g 1 506882 507130 ON 1 A05511 (506882..507130) no similarity KLLA0A05522g 1 507778 509481 ON 1 A05522 (507778..509481) similar to uniprot|P53309 Saccharomyces cerevisiae YGR241C YAP1802 Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin; member of clathrin assembly polypeptide AP180 family KLLA0A05544g 1 510371 513349 ON 1 A05544 (510371..513349) highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis indispensable for anaerobic growth activated by fructose-2 6- bisphosphate and AMP mutation inhibits glucose induction of cell cycle-related genes KLLA0A05566g 1 514368 514619 ON 1 A05566 (514368..514619) weakly similar to uniprot|Q3E7A3 Saccharomyces cerevisiae YJL133C-A Klac_YGOB_Anc_1.217 0 514934 515641 ON 1 Anc_1.217 complement(514934..515641) ANNOTATED BY YGOB - KLLA0A05621g 0 516514 528711 ON 1 A05621 complement(516514..528711) similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein microtubule motor protein required for anaphase spindle elongation involved in spindle assembly chromosome movement and spindle orientation during cell division targeted to microtubule tips by Pac1p KLLA0A05643g 1 528976 529632 ON 1 A05643 (528976..529632) similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins likely to be involved in the establishment of cell polarity KLLA0A05665g 1 529964 531700 ON 1 A05665 (529964..531700) similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation previously thought to be an endo-exonuclease KLLA0A05687g 0 531875 532354 ON 1 A05687 complement(531875..532354) no similarity KLLA0A05700g 1 532965 533756 ON 1 A05700 (532965..532988,533517..533756) highly similar to uniprot|P0C0V8 Saccharomyces cerevisiae YKR057W KLLA0A05709g 1 534438 535670 ON 1 A05709 (534438..535670) weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C KLLA0A05731g 1 536243 537433 ON 1 A05731 (536243..537433) highly similar to uniprot|P10081 Saccharomyces cerevisiae YKR059W TIF1 translation initiation factor eIF4A KLLA0A05753g 1 537889 538701 ON 1 A05753 (537889..538701) similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data KLLA0A05775g 1 538934 540268 ON 1 A05775 (538934..540268) similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W KTR2 Mannosyltransferase involved in N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family KLLA0A05797g 0 540318 540920 ON 1 A05797 complement(540318..540920) highly similar to uniprot|Q75BM1 Ashbya gossypii ACR250W ACR250Wp and similar to YJL140W uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32 forms two subunit dissociable complex with Rpb7p dispensable under some environmental conditions involved in export of mRNA to cytoplasm under stress conditions KLLA0A05819g 1 541545 543659 ON 1 A05819 (541545..543659) similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal KLLA0A05841g 0 543975 544439 ON 1 A05841 complement(543975..544439) highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Mitochondrial inner membrane protein involved in protein import 16.5 kDa inner membrane protein required for import of mitochondrial precursor proteins KLLA0A05852g 0 544850 545104 ON 1 A05852 complement(544850..545104) no similarity KLLA0A05863g 1 545949 547088 ON 1 A05863 (545949..547088) highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase catalyzes the conversion of dethiobiotin to biotin which is the last step of the biotin biosynthesis pathway complements E. coli bioB mutant KLLA0A05885g 0 547338 548231 ON 1 A05885 complement(547338..548231) similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 putative phosphatidylinositol transfer protein KLLA0A05907g 0 548720 549763 ON 1 A05907 complement(548720..549763) weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation KLLA0A05929g 1 550666 551748 ON 1 A05929 (550666..551748) weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C KLLA0A05951g 1 552438 553298 ON 1 A05951 (552438..553298) highly similar to uniprot|Q75BM7 Ashbya gossypii ACR244C ACR244Cp and similar to YKR062W uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit involved in RNA polymerase II transcription initiation KLLA0A05973g 0 553403 553987 ON 1 A05973 complement(553403..553987) weakly similar to uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5 KLLA0A06017g 0 555280 556650 ON 1 A06017 complement(555280..556650) similar to uniprot|Q75BM9 Ashbya gossypii ACR242W ACR242Wp and weakly similar to YKR063C uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis mutants require the SSD1-v allele for viability KLLA0A06039g 1 557368 559341 ON 1 A06039 (557368..559341) weakly similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W KLLA0A06061g 0 559396 560994 ON 1 A06061 complement(559396..560994) similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W KLLA0A06083g 0 562140 562730 ON 1 A06083 complement(562140..562730) similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C FMP18 The authentic non-tagged protein was localized to the mitochondria KLLA0A06105g 1 563147 564067 ON 1 A06105 (563147..564067) some similarities with uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein KLLA0A06127g 0 564088 564597 ON 1 A06127 complement(564088..564597) no similarity KLLA0A06149g 1 565427 565819 ON 1 A06149 (565427..565819) similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein that is essential for mitochondrial genome maintenance Single- stranded zinc finger DNA-binding protein KLLA0A06171g 1 566176 566535 ON 1 A06171 (566176..566535) similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Protein of unknown function proposed to be involved in the transfer of mannosylphosphate groups onto N-linked oligosaccharides also proposed to be involved in responding to osmotic stress KLLA0A06193g 1 566780 568096 ON 1 A06193 (566780..568096) similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H -pantothenate symporter confers sensitivity to the antifungal agent fenpropimorph KLLA0A06215g 1 568689 569927 ON 1 A06215 (568689..569927) similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p Mnn9p Mnn10p and Hoc1p and mediates elongation of the polysaccharide mannan backbone has homology to Mnn10p KLLA0A06237g 1 570630 573071 ON 1 A06237 (570630..573071) weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C KLLA0A06259g 0 573195 574178 ON 1 A06259 complement(573195..574178) similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase KLLA0A06281g 1 574472 574813 ON 1 A06281 (574472..574813) similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin which binds cytosolic chaperonin and transfers target proteins to it involved in the biogenesis of actin and of alpha- and gamma-tubulin KLLA0A06303g 0 575020 575877 ON 1 A06303 complement(575020..575877) similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type II membrane protein that binds phosphatidylinositol 3-phosphate required for the cytoplasm-to-vacuole targeting (Cvt) pathway KLLA0A06336g 1 576887 577850 ON 1 A06336 (576887..577195,577605..577850) similar to uniprot|P46990 Saccharomyces cerevisiae RPL17B Protein or YKL180W uniprot|P05740 Saccharomyces cerevisiae YKL180W RPL17A Protein component of the large (60S) ribosomal subunit KLLA0A06402g 0 578090 580057 ON 1 A06402 complement(578090..580057) similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C KLLA0A06424g 0 580397 583288 ON 1 A06424 complement(580397..583288) weakly similar to uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 transcription factor KLLA0A06446g 1 583793 584659 ON 1 A06446 (583793..584659) no similarity KLLA0A06468g 1 586957 587778 ON 1 A06468 (586957..587778) similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects KLLA0A06490g 0 588024 588374 ON 1 A06490 complement(588024..588374) similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination KLLA0A06512g 1 589213 591012 ON 1 A06512 (589213..591012) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions KLLA0A06534g 0 591225 592532 ON 1 A06534 complement(591225..592532) similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Cell surface a factor receptor transcribed in alpha cells and required for mating by alpha cells couples to MAP kinase cascade to mediate pheromone response ligand bound receptors undergo endocytosis and recycling to the plasma membrane KLLA0A06556g 0 593187 594386 ON 1 A06556 complement(593187..594386) similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C KLLA0A06578g 0 594872 595564 ON 1 A06578 complement(594872..595564) similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha-factor KLLA0A06600g 0 596010 598118 ON 1 A06600 complement(596010..598118) similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation methylates a lysine residue of histone H3 associates with the C-terminal domain of Rpo21p histone methylation activity is regulated by phosphorylation status of Rpo21p KLLA0A06622g 0 598561 600705 ON 1 A06622 complement(598561..600705) similar to uniprot|Q757Y7 Ashbya gossypii AEL127C AEL127Cp and weakly similar to YKL176C uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface KLLA0A06644g 1 601527 602948 ON 1 A06644 (601527..602948) similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter transports zinc from storage in the vacuole to the cytoplasm when needed transcription is induced under conditions of zinc deficiency KLLA0A06666g 0 603169 604851 ON 1 A06666 complement(603169..604851) similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine putative polyamine transporter in the Golgi or post-Golgi vesicles KLLA0A06688g 1 605011 607812 ON 1 A06688 (605011..607812) similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 involved in splicing U5 snRNP-specific protein related to EF-2 KLLA0A06710g 1 608103 609374 ON 1 A06710 (608103..609374) similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly localizes to the nucleolus KLLA0A06732g 1 609710 610759 ON 1 A06732 (609710..610759) highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167w ERG20 farnesyl-pyrophosphate synthetase KLLA0A06754g 1 611055 611339 ON 1 A06754 (611055..611339) highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Ubiquinol cytochrome-c reductase subunit 8 KLLA0A06776g 1 612115 614517 ON 1 A06776 (612115..614517) similar to uniprot|Q757Y0 Ashbya gossypii AEL120W AEL120Wp and some similarites with YKL171W uniprot|P36003 Saccharomyces cerevisiae YKL171W KLLA0A06798g 1 614979 615395 ON 1 A06798 (614979..615395) highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels KLLA0A06820g 0 615686 618004 ON 1 A06820 complement(615686..618004) weakly similar to uniprot|P38970 Saccharomyces cerevisiae YJL165C HAL5 Putative protein kinase overexpression increases sodium and lithium tolerance whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake suggesting a role in regulation of Trk1p and/or Trk2p transporters KLLA0A06842g 0 618848 620818 ON 1 A06842 complement(618848..620818) conserved hypothetical protein Klac_1.trna8K 1 621223 621295 ON 1 tK-CUU (621223..621295) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 77.59 KLLA0A06886g 0 621646 623409 ON 1 A06886 complement(621646..623409) similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source Klac_1.trna9K 1 625123 625195 ON 1 tK-CUU (625123..625195) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 77.59 KLLA0A06930g 0 625498 627261 ON 1 A06930 complement(625498..627261) similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease localization to the plasma membrane is regulated by nitrogen source KLLA0A06952g 0 628173 630323 ON 1 A06952 complement(628173..630323) similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C KLLA0A06974g 0 630572 631459 ON 1 A06974 complement(630572..631459) similar to uniprot|Q757W2 Ashbya gossypii AEL100W YNG2 Chromatin modification-related protein YNG2 and some similarities with YHR090C uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Yeast homolog of mammalian Ing1 NuA4 histone acetyltransferase complex component KLLA0A06996g 1 631799 632410 ON 1 A06996 (631799..632410) similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W KLLA0A07018g 0 632523 633092 ON 1 A07018 complement(632523..633092) highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C Protein required for cell viability KLLA0A07040g 0 633503 635452 ON 1 A07040 complement(633503..635452) highly similar to uniprot|Q05506 Saccharomyces cerevisiae YDR341C Cytoplasmic arginyl-tRNA synthetase KLLA0A07051g 0 635924 636275 ON 1 A07051 complement(635924..636086,636166..636275) no similarity KLLA0A07062g 0 636546 638291 ON 1 A07062 complement(636546..638291) highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Heat shock protein also induced by canavanine and entry into stationary phase KLLA0A07084g 1 638900 640483 ON 1 A07084 (638900..640483) similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C SET7 Nuclear protein that contains a SET-domain which have been shown to mediate methyltransferase activity in other proteins KLLA0A07106g 0 640536 641468 ON 1 A07106 complement(640536..641468) similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase delays anaphase in the presence of unattached kinetochores forms complexes with Mad1p-Bub1p and with Cdc20p binds Mad2p and Mad3p KLLA0A07128g 1 641974 643551 ON 1 A07128 (641974..643551) similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p KLLA0A07150g 0 643679 644251 ON 1 A07150 complement(643679..644251) weakly similar to uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP which cleaves pre-rRNA not shared between Rnase MRP and nuclear Rnase P in contrast to all other Rnase MRP protein subunits binds to the NME1 RNA subunit of Rnase MRP KLLA0A07172g 0 644634 646013 ON 1 A07172 complement(644634..646013) similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst4p in telomeric silencing cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism KLLA0A07194g 0 646573 647548 ON 1 A07194 complement(646573..646987,647529..647548) highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C RPS19A Protein component of the small (40S) ribosomal subunit or YNL302C uniprot|P07281 Saccharomyces cerevisiae YNL302C RPS19B Protein component of the small (40S) ribosomal subunit KLLA0A07227g 0 648431 649488 ON 1 A07227 complement(648431..648879,649377..649488) highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C RPL18A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation KLLA0A07249g 0 649905 651431 ON 1 A07249 complement(649905..651431) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0A07271g 0 651863 652408 ON 1 A07271 complement(651863..652408) highly similar to uniprot|Q75AS4 Ashbya gossypii ADL154C ADL154Cp and some similarities with uniprot|P38013 Saccharomyces cerevisiae YLR109w AHP1 Alkyl hydroperoxide reductase KLLA0A07293g 1 652702 654453 ON 1 A07293 (652702..654453) weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 subunit of COP9 Signalosome (CSN) like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 COP9 signalosome (CSN) subunit KLLA0A07315g 1 655210 655533 ON 1 A07315 (655210..655533) similar to uniprot|P48560 Saccharomyces cerevisiae YNL300W KLLA0A07337g 1 656187 657368 ON 1 A07337 (656187..657368) similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression invasive growth and pseudohyphal differentiation iron uptake chromium accumulation and response to osmotic stress localizes to the nucleus KLLA0A07359g 1 657936 659990 ON 1 A07359 (657936..659990) similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W TRF4 DNA polymerase sigma involved in mitotic chromsome condensation KLLA0A07381g 0 660082 660579 ON 1 A07381 complement(660082..660579) similar to gnl|GLV|CAGL0E02123g Candida glabrata CAGL0E02123g and weakly similar to YOL114C uniprot|Q12322 Saccharomyces cerevisiae YOL114C KLLA0A07403g 1 661261 663900 ON 1 A07403 (661261..663900) similar to uniprot|P48562 Saccharomyces cerevisiae YNL298W CLA4 Involved in localizing cell growth with respect to the septin ring protein kinase homologous to Ste20p interacts with CDC42 KLLA0A07425g 0 663956 668764 ON 1 A07425 complement(663956..668764) similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity interacts with Arl1p and localizes to the endosome member of the Sec7p family of proteins KLLA0A07447g 1 669272 670732 ON 1 A07447 (669272..670732) similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W KLLA0A07469g 0 670942 672501 ON 1 A07469 complement(670942..672501) similar to uniprot|Q758G4 Ashbya gossypii AEL202C RIM21 pH-response regulator protein palH/RIM21 and weakly similar to YNL294C uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Protein proposed to be involved in the response to alkaline pH; has similarity to A. nidulans PalH KLLA0A07491g 1 673198 675057 ON 1 A07491 (673198..675057) similar to uniprot|P48566 Saccharomyces cerevisiae YNL293W KLLA0A07513g 0 675169 675804 ON 1 A07513 complement(675169..675804) similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C KLLA0A07535g 1 676032 676808 ON 1 A07535 (676032..676808) similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase composed of Shr5p and Erf2p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage palmitoylation is required for Ras2p localization to the plasma membrane KLLA0A07557g 1 677067 679394 ON 1 A07557 (677067..679394) some similarities with uniprot|P36165 YKR089C Saccharomyces cerevisiae STC1 Protein of unknown function found in lipid particles potential Cdc28p substrate KLLA0A07579g 0 679469 681631 ON 1 A07579 complement(679469..681631) weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Protein of unknown function involved in invasive and pseudohyphal growth KLLA0A07601g 1 682057 683001 ON 1 A07601 (682057..683001) weakly similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis overproduction suppresses the sod1 (copper zinc superoxide dismutase) null mutation KLLA0A07623g 0 683112 683864 ON 1 A07623 complement(683112..683864) some similarities with uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA originally isolated as bud-site selection mutant that displays a random budding pattern KLLA0A07645g 0 684223 685041 ON 1 A07645 complement(684223..685041) conserved hypothetical protein KLLA0A07667g 1 685696 686613 ON 1 A07667 (685696..686613) similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0A07689g 0 686738 687457 ON 1 A07689 complement(686738..687457) similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W YORO77W KLLA0A07711g 1 687735 688772 ON 1 A07711 (687735..688772) highly similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane involved in turnover of membrane-embedded proteins member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes KLLA0A07733g 0 688856 692050 ON 1 A07733 complement(688856..692050) similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 RNA helicase in the DEAH-box family involved in the second catalytic step of splicing exhibits ATP- dependent RNA unwinding activity KLLA0A07755g 1 692606 693199 ON 1 A07755 (692606..693199) similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit KLLA0A07777g 0 693423 693911 ON 1 A07777 complement(693423..693911) conserved hypothetical protein KLLA0A07799g 1 694308 697112 ON 1 A07799 (694308..694563,694879..697112) similar to uniprot|P32769 Saccharomyces cerevisiae YKR084C KLLA0A07821g 0 697189 698178 ON 1 A07821 complement(697189..698178) similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex potential Cdc28p substrate endoplasmic reticulum t- SNARE coprecipitates with Sec20p Tip1p. and Sec22p KLLA0A07843g 1 698626 699564 ON 1 A07843 (698626..699564) highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase required for de novo biosynthesis of pyrimidine deoxyribonucleotides expression is induced at G1/S KLLA0A07865g 0 699725 701509 ON 1 A07865 complement(699725..701509) weakly similar to uniprot|O00031 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint involved in sensing lack of tension on mitotic chromosomes protects centromeric Rec8p at meiosis I required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability KLLA0A07887g 1 702046 702444 ON 1 A07887 (702046..702444) similar to uniprot|Q759Q6 Ashbya gossypii ADR217C DAD2 DASH complex subunit DAD2 and weakly similar to YKR083C uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore KLLA0A07909g 0 702533 705853 ON 1 A07909 complement(702533..705853) similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) localizes to both sides of the NPC required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p KLLA0A07931g 1 706289 707323 ON 1 A07931 (706289..707323) highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2 KLLA0A07953g 0 707461 708441 ON 1 A07953 complement(707461..708441) highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5 10- methylenetetrahydrafolate dehydrogenase plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p repressed by adenine and may be induced by inositol and choline KLLA0A07975g 1 709271 710911 ON 1 A07975 (709271..710911) similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p Sec4p Ypt7p and Ypt51p (in vitro) involved in vesicle docking and fusion KLLA0A07997g 1 711231 712958 ON 1 A07997 (711231..712958) similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) KLLA0A08019g 0 713019 714866 ON 1 A08019 complement(713019..714866) similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing contains multiple tetriatricopeptide repeats KLLA0A08041g 1 715347 717176 ON 1 A08041 (715347..717176) some similarities with uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis KLLA0A08063g 1 717703 719253 ON 1 A08063 (717703..719253) some similarities with uniprot|P47114 Saccharomyces cerevisiae YJR054W Vacuolar protein of unknown function potential Cdc28p substrate Klac_1.trna10R 1 719495 719566 ON 1 tR-CCU (719495..719566) tRNA Type: Arg (R) | Anti-Codon: CCU | Cove Score: 68.09 KLLA0A08107g 0 719825 720982 ON 1 A08107 complement(719825..720982) similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters including Gal2p involved in glucose-dependent repression KLLA0A08129g 1 722217 726026 ON 1 A08129 (722217..726026) similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 RNA splicing and ER to Golgi transport involved in secretion and RNA splicing KLLA0A08140g 0 726017 726985 ON 1 A08140 complement(726017..726985) similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W KLLA0A08162g 0 727416 728789 ON 1 A08162 complement(727416..728789) uniprot|Q06433 Kluyveromyces lactis KLLA0A08162g GAL80 Galactose/lactose metabolism regulatory protein GAL80 KLLA0A08184g 0 729440 730312 ON 1 A08184 complement(729440..730312) similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Multicopy suppressor of rvs167 mutation putative integral membrane protein KLLA0A08206g 1 730940 731632 ON 1 A08206 (730940..731632) some similarities with uniprot|P53907 Saccharomyces cerevisiae YNL144C Klac_1.trna11Y 0 731744 731842 ON 1 tY-GUA complement(731744..731779,731804..731842) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.95 Klac_1.trna12Q 1 732629 732700 ON 1 tQ-UUG (732629..732700) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 69.31 KLLA0A08316g 1 733200 735302 ON 1 A08316 (733200..735302) similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae KLLA0A08338g 1 736461 738761 ON 1 A08338 (736461..738761) similar to uniprot|P39684 Saccharomyces cerevisiae or to YHR015W uniprot|P38760 Saccharomyces cerevisiae KLLA0A08360g 0 739092 740764 ON 1 A08360 complement(739092..740316,740718..740764) similar to Saccharomyces cerevisiae YFR024C-A LSB3 or to YHR016C uniprot|P32793 Saccharomyces cerevisiae YHR016C YSC84 KLLA0A08382g 1 741712 742857 ON 1 A08382 (741712..742857) similar to uniprot|Q757L8 Ashbya gossypii AEL018C AEL018Cp and similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W KLLA0A08404g 0 743192 744577 ON 1 A08404 complement(743192..744577) highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase catalyzes the final step in the arginine biosynthesis pathway KLLA0A08426g 0 745048 746712 ON 1 A08426 complement(745048..746712) highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase required for protein synthesis catalyzes the specific attachment of asparagine to its cognate tRNA KLLA0A08448g 1 747134 749152 ON 1 A08448 (747134..749152) highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein required for cell viability KLLA0A08470g 0 749442 750446 ON 1 A08470 complement(749442..750446) similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase catalyzes the eighth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control KLLA0A08492g 1 751047 752168 ON 1 A08492 (751047..752168) conserved hypothetical protein Klac_1.trna13A 0 752342 752414 ON 1 tA-AGC complement(752342..752414) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0A08536g 1 753262 754161 ON 1 A08536 (753262..754161) some similarities with uniprot|P25587 Saccharomyces cerevisiae YCL005W Klac_1.trna14R 0 754348 754419 ON 1 tR-UCU complement(754348..754419) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 KLLA0A08580g 1 754857 756479 ON 1 A08580 (754857..756479) uniprot|Q874C6 Kluyveromyces lactis PGS1 CDP- diacylglycerol-glycerol-3-phosphate 3- phosphatidyltransferase KLLA0A08602g 0 756584 757493 ON 1 A08602 complement(756584..757326,757472..757493) similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C KLLA0A08624g 1 758042 758590 ON 1 A08624 (758042..758590) highly similar to uniprot|Q75ET0 Ashbya gossypii AAL002W AAL002Wp and similar to YCL001W uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins including Sec12p in the ER localized to Golgi functions as a retrieval receptor in returning membrane proteins to the ER KLLA0A08646g 1 758933 760099 ON 1 A08646 (758933..760099) highly similar to uniprot|Q75ES9 Ashbya gossypii AAL001W AAL001Wp and similar to YNL001W uniprot|P33309 Saccharomyces cerevisiae YNL001W DOM34 Probable RNA- binding protein functions in protein translation to promote G1 progression and differentiation required for meiotic cell division Klac_CEN1 1 760404 760598 ON 1 CEN1 (760404..760598) Chromosome I centromere KLLA0A08690g 0 761149 762084 ON 1 A08690 complement(761149..762084) no similarity KLLA0A08712g 0 762700 763440 ON 1 A08712 complement(762700..763440) highly similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Protein with similarity to methyltransferase family members; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0A08734g 1 763946 767434 ON 1 A08734 (763946..767434) similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding KLLA0A08756g 1 767756 769534 ON 1 A08756 (767756..767845,768005..769534) similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC) functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP potential Cdc28p substrate KLLA0A08778g 0 769697 770350 ON 1 A08778 complement(769697..770350) similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A ERP1 Protein that forms a heterotrimeric complex with Erp2p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles KLLA0A08800g 1 770989 772308 ON 1 A08800 (770989..772308) similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres KLLA0A08822g 1 772565 774313 ON 1 A08822 (772565..774313) similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 CDC20 homolog 1 protein required for Clb2 and Ase1 degradation KLLA0A08844g 0 774642 776507 ON 1 A08844 complement(774642..776507) similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination KLLA0A08866g 1 776960 778231 ON 1 A08866 (776960..778231) similar to uniprot|P53196 Saccharomyces cerevisiae YGL004C RPN14 Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome localized to the cytoplasm KLLA0A08888g 1 778534 779286 ON 1 A08888 (778534..779286) similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex KLLA0A08910g 0 779526 783368 ON 1 A08910 complement(779526..783368) similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 May be involved in depleting cytosol of Ca2 ions putative vacuolar Ca2 ATPase KLLA0A08932g 1 784599 785492 ON 1 A08932 (784599..785492) similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W Klac_1.trna15S 1 785743 785824 ON 1 tS-AGA (785743..785824) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 Klac_1.trna16A 1 785915 785987 ON 1 tA-UGC (785915..785987) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 76.57 KLLA0A09031g 1 787768 790467 ON 1 A09031 (787768..790467) highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H -ATPase pumps protons out of the cell major regulator of cytoplasmic pH part of the P2 subgroup of cation-transporting ATPases KLLA0A09075g 0 792171 793367 ON 1 A09075 complement(792171..793367) uniprot|P40952 Kluyveromyces lactis KLLA0A09075g KYE1 NADPH dehydrogenase 1 KLLA0A09097g 1 794827 797244 ON 1 A09097 (794827..797244) similar to uniprot|Q750N6 Ashbya gossypii AGL086C AGL086Cp and some similarites with YGL014W uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 member of the PUF protein family YGL014W KLLA0A09119g 0 797533 800781 ON 1 A09119 complement(797533..800781) weakly similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes KLLA0A09141g 1 801373 803655 ON 1 A09141 (801373..803655) weakly similar to uniprot|P38863 YHR172W Saccharomyces cerevisiae SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex KLLA0A09185g 1 804448 805761 ON 1 A09185 (804448..805761) highly similar to uniprot|P00924 Saccharomyces cerevisiae YGR254W ENO1 Enolase I and to uniprot|P00925 Saccharomyces cerevisiae YHR174W ENO2 Enolase II KLLA0A09207g 1 806124 806531 ON 1 A09207 (806124..806531) some similarities with uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2 KLLA0A09229g 1 806734 808005 ON 1 A09229 (806734..808005) similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins KLLA0A09251g 1 808253 810319 ON 1 A09251 (808253..810319) similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 binds Sin3p in two-hybrid assay Zinc finger (6-Cys) Klac_1.trna17T 1 810512 810583 ON 1 tT-UGU (810512..810583) tRNA Type: Thr (T) | Anti-Codon: UGU | Cove Score: 79.33 KLLA0A09295g 1 810967 811647 ON 1 A09295 (810967..811647) similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Component of Sed5p vesicles KLLA0A09317g 1 811860 813809 ON 1 A09317 (811860..813809) weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm KLLA0A09339g 1 814960 816438 ON 1 A09339 (814960..816438) highly similar to uniprot|P53319 Saccharomyces cerevisiae YGR256W GND2 and to uniprot|P38720 Saccharomyces cerevisiae YHR183W GND1 6-phosphogluconate dehydrogenase(decarboxylating) KLLA0A09361g 1 816911 818611 ON 1 A09361 (816911..818611) weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and spore formation KLLA0A09383g 0 818752 819852 ON 1 A09383 complement(818752..819852) similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor KLLA0A09405g 0 820161 820970 ON 1 A09405 complement(820161..820970) some similarities with uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein KLLA0A09427g 0 821244 824279 ON 1 A09427 complement(821244..824279) similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPG protein KLLA0A09449g 1 825574 827106 ON 1 A09449 (825574..827106) similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease KLLA0A09471g 0 827264 831784 ON 1 A09471 complement(827264..831784) some similarities with uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1 a rapamycin- sensitive complex involved in growth control that contains Tor1p or Tor2p Lst8p and Tco89p contains four HEAT repeats and seven WD-40 repeats may act as a scaffold protein to couple TOR and its effectors KLLA0A09493g 1 832430 833317 ON 1 A09493 (832430..833317) similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of the Elp4p-Iki1p-Elp6p-subcomplex of RNA polymerase II elongator complex which is a histone acetyltransferase iki1 mutations confer resistance to the K. lactis toxin zymocin KLLA0A09515g 0 833455 835386 ON 1 A09515 complement(833455..835386) similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins human PIG-Tp homolog KLLA0A09537g 1 835653 838517 ON 1 A09537 (835653..838517) similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 KLLA0A09559g 0 838592 840970 ON 1 A09559 complement(838592..840970) similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 beta3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function putative beta adaptin component of the membrane-associate clathrin assembly complex Klac_1.trna18K 0 841221 841293 ON 1 tK-CUU complement(841221..841293) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 77.59 KLLA0A09603g 1 841883 843100 ON 1 A09603 (841883..843100) similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 4-amino-4-deoxychorismate lyase catalyzes the third step in para-aminobenzoic acid biosynthesis KLLA0A09625g 0 843147 843938 ON 1 A09625 complement(843147..843938) highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0A09647g 0 844245 846578 ON 1 A09647 complement(844245..846578) highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p which increases the catalytic efficiency of both tRNA synthetases also has a role in nuclear export of tRNAs KLLA0A09669g 0 847036 848529 ON 1 A09669 complement(847036..848529) highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase localizes to both the nuclear periphery and nucleolus highly enriched in nuclear pore complex fractions KLLA0A09691g 1 849221 851305 ON 1 A09691 (849221..851305) similar to uniprot|P53326 YGR266W Saccharomyces cerevisiae probably contains a single transmembrane span KLLA0A09713g 1 851952 853625 ON 1 A09713 (851952..853625) similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W KLLA0A09735g 0 854163 854900 ON 1 A09735 complement(854163..854900) highly similar to uniprot|P51601 YGR267C Saccharomyces cerevisiae FOL2 GTP-cyclohydrolase I KLLA0A09757g 0 855406 855999 ON 1 A09757 complement(855406..855999) some similarities with uniprot|P40325 YGR268C Saccharomyces cerevisiae HUA1 uncharacterized ORF KLLA0A09779g 0 856553 857008 ON 1 A09779 complement(856553..857008) some similarities with uniprot|P40325 Saccharomyces cerevisiae YGR268C KLLA0A09801g 1 857479 858089 ON 1 A09801 (857479..857506,857695..858089) similar to uniprot|Q03554 Saccharomyces cerevisiae YMR292w GOT1 evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes KLLA0A09823g 1 858458 862417 ON 1 A09823 (858458..862417) similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein of unknown function member of CDC48/PAS1/SEC18 family of ATPases potentially phosphorylated by Cdc28p KLLA0A09845g 0 862467 863876 ON 1 A09845 complement(862467..863876) similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C Uncharacterized ORF KLLA0A09867g 1 864111 865193 ON 1 A09867 (864111..865193) similar to uniprot|Q75D83 Ashbya gossypii ABR141W ABR141Wp and some similarites with YMR294W uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex consisting of Nip100p Jnm1p and Arp1p required for proper nuclear migration and spindle partitioning during mitotic anaphase B KLLA0A09889g 1 865422 871304 ON 1 A09889 (865422..871304) highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 SKI2-like helicase KLLA0A09911g 0 871390 872076 ON 1 A09911 complement(871390..872076) similar to uniprot|P53328 Saccharomyces cerevisiae YGR272C KLLA0A09933g 0 872665 873258 ON 1 A09933 complement(872665..873258) similar to uniprot|Q03559 Saccharomyces cerevisiae YMR295C Protein of unknown function KLLA0A09955g 0 873688 875355 ON 1 A09955 complement(873688..875355) similar to uniprot|P25045 Saccharomyces cerevisiae YMR296C LCB1 Component of serine palmitoyltransferase responsible along with Lcb2p for the first committed step in sphingolipid synthesis KLLA0A09977g 1 876594 878201 ON 1 A09977 (876594..878201) similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C) involved in protein degradation in the vacuole and required for full protein degradation during sporulation KLLA0A09999g 1 878563 879006 ON 1 A09999 (878563..879006) similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W Protein required for cell viability KLLA0A10021g 0 879152 882253 ON 1 A10021 complement(879152..882253) similar to uniprot|P46677 YGR274C Saccharomyces cerevisiae TAF1 TFIID subunit (145 kDa) involved in RNA polymerase II transcription initiation KLLA0A10043g 1 882810 883271 ON 1 A10043 (882810..883271) weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Regulator of Ty1 Transposition; regulator of Ty1 transposition KLLA0A10065g 0 883467 885515 ON 1 A10065 complement(883467..885515) similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3'exoribonuclease required for 5S and tRNA- Arg3 maturation KLLA0A10087g 0 885994 887106 ON 1 A10087 complement(885994..887106) weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC) localizes with dynein null mutant is defective in nuclear migration KLLA0A10109g 0 887498 889027 ON 1 A10109 complement(887498..889027) highly similar to uniprot|P04046 YMR300C Saccharomyces cerevisiae ADE4 Phosphoribosylpyrophosphate amidotransferase KLLA0A10131g 0 889688 891850 ON 1 A10131 complement(889688..891850) similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane transporter exports mitochondrially synthesized precursors of iron- sulfur (Fe/S) clusters to the cytosol member of the ATP- binding cassette (ABC) transporter family KLLA0A10153g 0 892398 893099 ON 1 A10153 complement(892398..893099) highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 20S proteasome alpha-type subunit KLLA0A10175g 1 893626 895401 ON 1 A10175 (893626..895401) similar to uniprot|P40308 Saccharomyces cerevisiae YMR313C TGL3 Triacylglycerol lipase of the lipid particle KLLA0A10197g 0 895418 896227 ON 1 A10197 complement(895418..896227) similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity KLLA0A10219g 1 896931 898358 ON 1 A10219 (896931..898358) similar to uniprot|Q75BF2 Ashbya gossypii ADL388W ADL388Wp and some similarites with YHR206W uniprot|P38889 Saccharomyces cerevisiae KLLA0A10241g 0 898752 900230 ON 1 A10241 complement(898752..900230) similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5 KLLA0A10263g 1 900517 901284 ON 1 A10263 (900517..901284) similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 The authentic non-tagged protein was localized to the mitochondria KLLA0A10285g 0 901341 902216 ON 1 A10285 complement(901341..902216) similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5 10-methenyltetrahydrofolate synthetase involved in folic acid biosynthesis KLLA0A10307g 1 902374 903597 ON 1 A10307 (902374..903597) highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W BAT1 Mitochondrial branched-chain amino acid aminotransferase homolog of murine ECA39 highly expressed during logarithmic phase and repressed during stationary phase KLLA0A10329g 1 903873 905792 ON 1 A10329 (903873..905792) conserved hypothetical protein KLLA0A10351g 0 906401 907087 ON 1 A10351 complement(906401..907087) weakly similar to uniprot|Q9A7D3 Caulobacter crescentus CC1790 Hypothetical protein CC1790 KLLA0A10373g 0 907244 907864 ON 1 A10373 complement(907244..907864) some similarities with uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism sole identified regulatory target is SSU1 overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1 contains five zinc fingers KLLA0A10395g 0 908097 908981 ON 1 A10395 complement(908097..908981) similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C KLLA0A10417g 0 910347 912176 ON 1 A10417 complement(910347..912176) uniprot|Q9Y746 Kluyveromyces lactis KLLA0A10417g INV1 Invertase precursor KLLA0A10439g 0 913342 915246 ON 1 A10439 complement(913342..915246) similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores KLLA0A10461g 1 916547 917332 ON 1 A10461 (916547..917332) similar to uniprot|P36087 Saccharomyces cerevisiae YKL070W KLLA0A10483g 0 917868 918620 ON 1 A10483 complement(917868..918293,918576..918620) highly similar to uniprot|P26781 Saccharomyces cerevisiae YDR025w RPS18A or uniprot|P26781 Saccharomyces cerevisiae YBR048w RPS18B ribosomal protein KLLA0A10505g 1 918705 919115 ON 1 A10505 (918705..919115) no similarity KLLA0A10527g 0 919456 920004 ON 1 A10527 complement(919456..920004) similar to uniprot|P38231 Saccharomyces cerevisiae YBR047W FMP23 The authentic non-tagged protein was localized to the mitochondria KLLA0A10549g 1 921022 922083 ON 1 A10549 (921022..922083) highly similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C KLLA0A10571g 1 922516 924201 ON 1 A10571 (922516..924201) weakly similar to uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific protein proposed to be a regulatory subunit of the protein phosphatase Glc7p, required for spore wall formation and proper septin organization KLLA0A10593g 0 924496 925875 ON 1 A10593 complement(924496..925875) highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 seryl-tRNA synthetase Klac_1.trna19V 1 926295 926368 ON 1 tV-UAC (926295..926368) tRNA Type: Val (V) | Anti-Codon: UAC | Cove Score: 71.06 KLLA0A10637g 1 926574 927005 ON 1 A10637 (926574..927005) weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Protein involved in microtubule assembly KLLA0A10659g 0 927059 928255 ON 1 A10659 complement(927059..928255) highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases KLLA0A10681g 1 928563 929657 ON 1 A10681 (928563..929657) similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 member of the syntaxin family of t-SNAREs KLLA0A10703g 0 929877 931715 ON 1 A10703 complement(929877..931715) some similarities with uniprot|Q08157 Saccharomyces cerevisiae YOL019W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole Klac_1.trna20Y 0 932445 932543 ON 1 tY-GUA complement(932445..932480,932505..932543) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.95 KLLA0A10769g 1 933157 933618 ON 1 A10769 (933157..933618) similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C KLLA0A10791g 0 934135 935733 ON 1 A10791 complement(934135..935573,935718..935733) similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome releases free ubiquitin from branched polyubiquitin chains deletion causes hypersensitivity to cycloheximide and other toxic compounds KLLA0A10813g 0 936126 937880 ON 1 A10813 complement(936126..937880) similar to uniprot|P38967 Saccharomyces cerevisiae YOL020W TAT2 Tryptophan permease high affinity KLLA0A10835g 1 938712 941738 ON 1 A10835 (938712..941738) highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Nucleolar exosome component involved in rRNA processing and RNA degradation binds Gsp1p/Ran and enhances the GEF activity of Srm1p implicated in mitotic control homologous to the E. coli RNase R of the RNase II family KLLA0A10857g 0 941784 944042 ON 1 A10857 complement(941784..944042) highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn1p proposed to stimulate Gcn2p activation by an uncharged tRNA Klac_1.trna21G 0 944431 944501 ON 1 tG-GCC complement(944431..944501) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0A10901g 1 945121 946407 ON 1 A10901 (945121..946407) similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C Protein required for cell viability KLLA0A10923g 0 946489 948501 ON 1 A10923 complement(946489..948501) similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2 KLLA0A10945g 0 948881 950086 ON 1 A10945 complement(948881..950086) weakly similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 KLLA0A10967g 0 950412 950942 ON 1 A10967 complement(950412..950942) no similarity KLLA0A10989g 0 951316 952923 ON 1 A10989 complement(951316..952923) conserved hypothetical protein KLLA0A11011g 1 953797 955047 ON 1 A11011 (953797..955047) highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1 3-bisphosphoglycerate to ADP to produce ATP key enzyme in glycolysis and gluconeogenesis KLLA0A11033g 0 955278 956798 ON 1 A11033 complement(955278..956798) weakly similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 Probable homolog of mammalian DNA polymerase beta may function in double-stranded DNA break repair DNA polymerase IV KLLA0A11044g 0 956792 957493 ON 1 A11044 complement(956792..957493) some similarities with uniprot|P25616 Saccharomyces cerevisiae YCR015C KLLA0A11066g 1 958239 959087 ON 1 A11066 (958239..959087) similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W KLLA0A11088g 1 959342 962446 ON 1 A11088 (959342..962446) conserved hypothetical protein KLLA0A11110g 1 964084 965739 ON 1 A11110 (964084..965739) uniprot|P49374 Kluyveromyces lactis KLLA0A11110g HGT1 High-affinity glucose transporter KLLA0A11132g 0 967049 969982 ON 1 A11132 complement(967049..969982) similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites null mutation is synthetically lethal with pkc1 deletion Klac_1.trna22K 1 970437 970509 ON 1 tK-CUU (970437..970509) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 77.59 KLLA0A11176g 0 970974 973133 ON 1 A11176 complement(970974..973133) highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme involved in glycogen accumulation green fluorescent protein (GFP)- fusion protein localizes to the cytoplasm in a punctate pattern KLLA0A11198g 0 973755 974529 ON 1 A11198 complement(973755..974358,974525..974529) similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro KLLA0A11209g 0 974831 975076 ON 1 A11209 complement(974831..975076) similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Subunit of the RSC chromatin remodeling complex, a multisubunit complex that functions in transcriptional regulation,chromosome stability and establishing sister chromatid cohesion KLLA0A11220g 1 975454 975729 ON 1 A11220 (975454..975729) similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus member of the Sm protein family KLLA0A11242g 0 975786 976844 ON 1 A11242 complement(975786..976844) similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles Klac_1.trna23M 1 977210 977281 ON 1 tM-CAU (977210..977281) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.96 KLLA0A11286g 0 978095 979834 ON 1 A11286 complement(978095..979834) highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated vacuolar membrane protein that interacts with Atg13p required for the cytoplasm-to-vacuole targeting (Cvt) pathway interacts with Nvj1p to form nucleus-vacuole junctions KLLA0A11308g 0 980616 982022 ON 1 A11308 complement(980616..982022) weakly similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p localizes to cytoplasmic mRNA processing bodies KLLA0A11330g 1 982552 983124 ON 1 A11330 (982552..983124) similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins KLLA0A11352g 0 983428 984372 ON 1 A11352 complement(983428..984372) some similarities with uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene KLLA0A11374g 0 985471 987336 ON 1 A11374 complement(985471..987336) some similarities with uniprot|P25353 Saccharomyces cerevisiae YCR026C NPP1 KLLA0A11396g 0 987998 988912 ON 1 A11396 complement(987998..988912) weakly similar to uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism as suggested by computational analysis of large-scale protein-protein interaction data GFP-fusion protein localizes to the nuclear periphery Klac_YGOB_PMP1 1 990001 990120 ON 1 PMP1 (990001..990120) ANNOTATED BY YGOB - KLLA0A11440g 0 990779 991606 ON 1 A11440 complement(990779..991606) weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor, subunit of the NuA4 acetyltransferase complex KLLA0A11462g 1 991845 992615 ON 1 A11462 (991845..992615) similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 Protein involved in DNA repair mutants are sensitive to the alkylating agent methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination KLLA0A11484g 1 992734 994158 ON 1 A11484 (992734..994158) similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase KLLA0A11506g 1 994478 994870 ON 1 A11506 (994478..994870) similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C Protein required for cell viability KLLA0A11528g 1 995143 995889 ON 1 A11528 (995143..995889) similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31 contains HMG- like C-terminal domain KLLA0A11550g 0 996087 997151 ON 1 A11550 complement(996087..997151) conserved hypothetical protein KLLA0A11572g 0 997457 998623 ON 1 A11572 complement(997457..998623) similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W Protein required for cell viability KLLA0A11594g 0 998888 1003480 ON 1 A11594 complement(998888..1003480) similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C RLR1 Required for LacZ RNA expression from certain plasmids suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) plays a role in transcription elongation by RNA polymerase II Involved in transcription KLLA0A11605g 1 1003776 1004115 ON 1 A11605 (1003776..1003778,1003855..1004115) similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A RCP10 Component of the U2 snRNP, associated with the SF3b complex; conserved in Ashbya gossypii KLLA0A11616g 0 1004255 1004896 ON 1 A11616 complement(1004255..1004896) some similarities with uniprot|P38833 Saccharomyces cerevisiae YHR127W (H)igh copy (S)uppressor of (N)34 dominant negative allele of SEC4. Suppression is very specific to this allele. It has no affect on the analogous YPT1 allele. No homology or known function KLLA0A11638g 1 1005270 1006913 ON 1 A11638 (1005270..1006913) similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 Adenylyl cyclase-associated protein N- terminal domain appears to be involved in cellular responsiveness to RAS KLLA0A11660g 0 1007120 1008568 ON 1 A11660 complement(1007120..1008568) similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit KLLA0A11682g 1 1008960 1010168 ON 1 A11682 (1008960..1010168) some similarities with uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex which acetylates the N-terminal tails of histones H4 and H2A KLLA0A11704g 0 1010467 1010811 ON 1 A11704 complement(1010467..1010811) highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function KLLA0A11748g 1 1012732 1013991 ON 1 A11748 (1012732..1013991) conserved hypothetical protein KLLA0A11770g 1 1014918 1016663 ON 1 A11770 (1014918..1016663) similar to uniprot|P06775 Saccharomyces cerevisiae YGR191W HIP1 High-affinity histidine permease also involved in the transport of manganese ions KLLA0A11792g 1 1017064 1021095 ON 1 A11792 (1017064..1021095) conserved hypothetical protein KLLA0A11814g 1 1021526 1022434 ON 1 A11814 (1021526..1022434) highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2 involved in the identification of the start codon phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP KLLA0A11836g 1 1023063 1024028 ON 1 A11836 (1023063..1024028) similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W KLLA0A11858g 0 1024297 1025292 ON 1 A11858 complement(1024297..1025292) highly similar to uniprot|P00358 TDH2, to YGR192C uniprot|P00359 TDH3 and to YJL052W uniprot|P00360 TDH1 Saccharomyces cerevisiae glyceraldehyde 3-phosphate dehydrogenases KLLA0A11913g 1 1029032 1029448 ON 1 A11913 (1029032..1029448) no similarity KLLA0A11935g 1 1031062 1034418 ON 1 A11935 (1031062..1034418) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W KLLA0A11957g 1 1041208 1041834 ON 1 A11957 (1041208..1041834) conserved hypothetical protein KLLA0A11979g 0 1041901 1043079 ON 1 A11979 complement(1041901..1043079) some similarities with uniprot|Q87020 Killer virus of S KIL K2 killer toxin precursor KLLA0A12001g 1 1044941 1045321 ON 1 A12001 (1044941..1045321) no similarity KLLA0A12045g 0 1048618 1049781 ON 1 A12045 complement(1048618..1049781) some similarities with uniprot|P53054 Saccharomyces cerevisiae YGL262W KLLA0A12067g 0 1050804 1051145 ON 1 A12067 complement(1050804..1051145) conserved hypothetical protein KLLA0A12089g 1 1052066 1052611 ON 1 A12089 (1052066..1052611) similar to uniprot|Q5WCY3 Bacillus clausii ABC3243 paiA Septation and degradation transcriptional repressor of sporulation KLLA0B00143g 1 4365 5888 ON 2 B00143 (4365..5888) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0B00166g 0 6575 6793 ON 2 B00166 complement(6575..6793) conserved hypothetical protein KLLA0B00187g 1 7994 8317 ON 2 B00187 (7994..8317) conserved hypothetical protein KLLA0B00220g 0 8804 9181 ON 2 B00220 complement(8804..9181) conserved hypothetical protein KLLA0B00242g 0 9894 11666 ON 2 B00242 complement(9894..11666) similar to uniprot|Q08295 Saccharomyces cerevisiae YOL157C KLLA0B00264g 1 12844 14574 ON 2 B00264 (12844..14574) uniprot|Q9Y845 Kluyveromyces lactis mal21 Maltose permease KLLA0B00286g 0 15257 16666 ON 2 B00286 complement(15257..16666) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin KLLA0B00308g 0 18349 19698 ON 2 B00308 complement(18349..19698) some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W KLLA0B00352g 1 22476 23972 ON 2 B00352 (22476..23972) highly similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W KLLA0B00385g 0 25847 27541 ON 2 B00385 complement(25847..27541) similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway responsible for uptake of 7-keto 8-aminopelargonic acid BIO5 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis KLLA0B00407g 0 27872 28558 ON 2 B00407 complement(27872..28558) similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase catalyzes the third step in the biotin biosynthesis pathway BIO4 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis expression appears to be repressed at low iron levels KLLA0B00429g 1 29147 30598 ON 2 B00429 (29147..30598) similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7 8-diamino-pelargonic acid aminotransferase (DAPA) catalyzes the second step in the biotin biosynthesis pathway BIO3 is in a cluster of 3 genes (BIO3 BIO4 and BIO5) that mediate biotin synthesis KLLA0B00451g 0 31822 32982 ON 2 B00451 complement(31822..32982) weakly similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase KLLA0B00473g 0 35614 36861 ON 2 B00473 complement(35614..36861) conserved hypothetical protein KLLA0B00495g 0 37797 38663 ON 2 B00495 complement(37797..38663) conserved hypothetical protein KLLA0B00517g 1 39267 39893 ON 2 B00517 (39267..39893) some similarities with uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 Associates with translating ribosomes KLLA0B00539g 0 40064 41737 ON 2 B00539 complement(40064..41737) similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W ABC1 Protein required for ubiquinone (coenzyme Q) biosynthesis which in turn is required for respiratory growth KLLA0B00561g 1 42284 44587 ON 2 B00561 (42284..44587) highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family involved in release of the lariat-intron from the spliceosome KLLA0B00583g 0 44819 46279 ON 2 B00583 complement(44819..46279) uniprot|Q00995 Kluyveromyces lactis FOG1 protein Klac_YGOB_Anc_3.518 0 46736 47455 ON 2 Anc_3.518 complement(46736..47455) ANNOTATED BY YGOB - KLLA0B00627g 0 48523 49098 ON 2 B00627 complement(48523..49098) similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 associated with U1 U2 U4 and U5 snRNPs as part of the Sm-core that is common to all spliceosomal snRNPs U1 snRNP protein KLLA0B00649g 1 49535 50053 ON 2 B00649 (49535..50053) similar to uniprot|P40019 Saccharomyces cerevisiae YER030W KLLA0B00671g 0 50393 51462 ON 2 B00671 complement(50393..51006,51417..51462) highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W YPT32 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment; ras-like GTPase, highly homologous to YPT31 KLLA0B00693g 1 52711 55278 ON 2 B00693 (52711..55278) similar to uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate KLLA0B00715g 0 55372 57834 ON 2 B00715 complement(55372..57834) some similarities with uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Cytoplasmic protein of unknown function transcription is induced under conditions of zinc deficiency KLLA0B00737g 0 58094 59209 ON 2 B00737 complement(58094..59209) some similarities with uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein with a role in urmylation and in invasive and pseudohyphal growth KLLA0B00759g 1 59965 61335 ON 2 B00759 (59965..61335) some similarities with uniprot|P28742 Saccharomyces cerevisiae YBL063W KIP1 Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p KLLA0B00781g 0 61451 61939 ON 2 B00781 complement(61451..61681,61768..61790,61930..61939) similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein microtubule motor protein KLLA0B00803g 1 62255 63982 ON 2 B00803 (62255..63982) weakly similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin that mediates retrieval from endosomes KLLA0B00825g 1 64284 65468 ON 2 B00825 (64284..65468) similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W KLLA0B00847g 0 65983 66792 ON 2 B00847 complement(65983..66792) similar to uniprot|Q04067 YDR429C Saccharomyces cerevisiae TIF35 Subunit of the core complex of translation initiation factor 3(eIF3) KLLA0B00869g 1 67723 67938 ON 2 B00869 (67723..67938) similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit KLLA0B00891g 0 68242 71352 ON 2 B00891 complement(68242..71352) similar to uniprot|P27692 YML010W Saccharomyces cerevisiae SPT5 Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation KLLA0B00913g 1 71670 72200 ON 2 B00913 (71670..72200) similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C KLLA0B00935g 0 72528 73166 ON 2 B00935 complement(72528..73166) similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1 Erp2p and Emp24 member of the p24 family involved in endoplasmic reticulum to Golgi transport KLLA0B00957g 0 73661 76609 ON 2 B00957 complement(73661..76609) similar to uniprot|P32898 YDR430C Saccharomyces cerevisiae CYM1 Cytosolic metalloprotease KLLA0B00979g 1 77439 78467 ON 2 B00979 (77439..78467) weakly similar to uniprot|Q01560 YDR432W Saccharomyces cerevisiae NPL3 RNA-binding protein that carries poly(A) mRNA from the nucleus into the cytoplasm KLLA0B01001g 0 79432 81294 ON 2 B01001 complement(79432..81294) uniprot|Q7ZA19 Kluyveromyces lactis sel1 Secretion lowering protein KLLA0B01023g 0 81664 82509 ON 2 B01023 complement(81664..82509) similar to uniprot|P49957 YML014W Saccharomyces cerevisiae TRM9 tRNA methyltransferase KLLA0B01045g 1 82972 84522 ON 2 B01045 (82972..84522) similar to uniprot|Q04080 YDR434W Saccharomyces cerevisiae GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins KLLA0B01067g 1 84876 85928 ON 2 B01067 (84876..85928) similar to uniprot|Q04226 YML015C Saccharomyces cerevisiae TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation KLLA0B01089g 0 85996 86997 ON 2 B01089 complement(85996..86997) similar to uniprot|Q04081 YDR435C Saccharomyces cerevisiae PPM1 Carboxyl methyl transferase KLLA0B01111g 1 88088 90067 ON 2 B01111 (88088..90067) some similarities with uniprot|P26570 Saccharomyces cerevisiae YML016C PPZ1 Serine/threonine protein phosphatase Z isoform of Ppz2p involved in regulation of potassium transport KLLA0B01133g 1 90746 91141 ON 2 B01133 (90746..91141) similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W Protein required for cell viability KLLA0B01155g 0 91522 93204 ON 2 B01155 complement(91522..93204) weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha) possible role in mitochondrial mRNA splicing KLLA0B01177g 1 94268 95512 ON 2 B01177 (94268..95512) similar to uniprot|Q03730 YML018C Saccharomyces cerevisiae KLLA0B01199g 0 95848 96846 ON 2 B01199 complement(95848..96846) similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W KLLA0B01221g 1 97172 97843 ON 2 B01221 (97172..97843) some similarities with uniprot|Q04087 Saccharomyces cerevisiae YDR439W KLLA0B01243g 0 97985 99868 ON 2 B01243 complement(97985..99868) similar to uniprot|Q03722 YML020W Saccharomyces cerevisiae KLLA0B01265g 1 100414 101430 ON 2 B01265 (100414..101430) similar to uniprot|P12887 YML021C Saccharomyces cerevisiae UNG1 uracil DNA glycosylase KLLA0B01287g 1 101771 103489 ON 2 B01287 (101771..103489) similar to uniprot|Q04089 YDR440W Saccharomyces cerevisiae DOT1 Nucleosomal histone H3-Lys79 methylase KLLA0B01309g 0 103734 104297 ON 2 B01309 complement(103734..104297) similar to uniprot|P49435 YML022W Saccharomyces cerevisiae APT1 Adenine phosphoribosyltransferase KLLA0B01331g 1 104649 106199 ON 2 B01331 (104649..106199) weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Protein required for cell viability KLLA0B01353g 0 106220 110383 ON 2 B01353 complement(106220..110383) similar to uniprot|P38931 YDR443C Saccharomyces cerevisiae SSN2 Required for stable association of Srb10p- Srb11p kinase with RNA polymerase holoenzyme KLLA0B01375g 1 110709 112631 ON 2 B01375 (110709..112631) similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W KLLA0B01397g 0 112771 114489 ON 2 B01397 complement(112771..114489) similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane Klac_2.trna1K 0 115139 115211 ON 2 tK-CUU complement(115139..115211) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 79.43 KLLA0B01452g 1 115562 116410 ON 2 B01452 (115562..116410) weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein of unknown function GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis may be involved in maintaining chromatin structure KLLA0B01474g 0 116705 117771 ON 2 B01474 complement(116705..117112,117769..117771) highly similar to uniprot|P02407 Saccharomyces cerevisiae YML024W RPS17A and to uniprot|P14127 Saccharomyces cerevisiae YDR447C RPS17B Ribosomal proteins 51 (rp51) of the small (40s) subunit KLLA0B01496g 1 118526 119833 ON 2 B01496 (118526..119833) highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes KLLA0B01518g 0 119927 121291 ON 2 B01518 complement(119927..121291) similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0B01540g 1 121864 122820 ON 2 B01540 (121864..121902,122071..122820) similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit KLLA0B01562g 1 123623 124593 ON 2 B01562 (123623..123669,124200..124593) highly similar to uniprot|P35271 Saccharomyces cerevisiae YML026C RPS18B and to uniprot|P35271 Saccharomyces cerevisiae YDR450W RPS18A proteins component of the small (40S) ribosomal subunit KLLA0B01584g 0 125027 126421 ON 2 B01584 complement(125027..126421) weakly similar to uniprot|P34161 Saccharomyces cerevisiae YML027W YOX1 Homeodomain-containing transcriptional repressor binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle- regulated genes expressed in M/G1 phase expression is cell cycle-regulated potential Cdc28p substrate KLLA0B01606g 1 127978 130023 ON 2 B01606 (127978..130023) similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism functions as a homodimer KLLA0B01628g 0 130395 130988 ON 2 B01628 complement(130395..130988) highly similar to uniprot|P34760 Saccharomyces cerevisiae YML028W TSA1 and to uniprot|Q04120 Saccharomyces cerevisiae YDR453C TSA2 Thioredoxin- peroxidase KLLA0B01650g 0 131822 134395 ON 2 B01650 complement(131822..134395) some similarities with uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Protein that interacts in the two- hybrid system with the U1 snRNP-specific protein Snp1p may have a role in pre-mRNA splicing KLLA0B01672g 0 134909 135385 ON 2 B01672 complement(134909..135385) similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W KLLA0B01694g 0 135778 136356 ON 2 B01694 complement(135778..136356) similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins KLLA0B01738g 1 137171 139015 ON 2 B01738 (137171..139015) similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Endosomal Na+/H+ exchanger KLLA0B01760g 0 139684 141504 ON 2 B01760 complement(139684..141504) similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains KLLA0B01782g 1 142413 143723 ON 2 B01782 (142413..143723) uniprot|P41768 Kluyveromyces lactis KLLA0B01782g RAD52 DNA repair and recombination protein RAD52 KLLA0B01804g 1 144223 153951 ON 2 B01804 (144223..153951) similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 Temperature dependent Organization in Mitotic nucleus Klac_YGOB_G04906 0 154285 154518 ON 2 G04906 complement(154285..154518 ANNOTATED BY YGOB - KLLA0B01826g 0 155830 158455 ON 2 B01826 complement(155830..156444,156659..158455) similar to uniprot|Q03707 Saccharomyces cerevisiae YML034W SRC1 KLLA0B01848g 1 159037 161046 ON 2 B01848 (159037..161046) similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 The authentic non-tagged protein was localized to the mitochondria KLLA0B01870g 1 161382 162401 ON 2 B01870 (161382..162401) no similarity KLLA0B01892g 1 162844 165855 ON 2 B01892 (162844..165855) weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria KLLA0B01914g 1 166552 168921 ON 2 B01914 (166552..168921) similar to uniprot|Q08967 Saccharomyces cerevisiae YPL221W BOP1 Protein of unknown function overproduction suppresses a pam1 slv3 double null mutation KLLA0B01936g 0 169003 170217 ON 2 B01936 complement(169003..170217) weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C KLLA0B01958g 1 170646 173550 ON 2 B01958 (170646..170663,170896..173550) highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Involved in beta'-subunit of yeast coatomer KLLA0B01980g 0 173710 174579 ON 2 B01980 complement(173710..174579) similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ KLLA0B02002g 1 175242 175895 ON 2 B02002 (175242..175895) highly similar to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1A and to uniprot|P53030 Saccharomyces cerevisiae YPL220W RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit KLLA0B02024g 1 176585 178168 ON 2 B02024 (176585..178168) some similarities with uniprot|P53124 Saccharomyces cerevisiae YGL134W PCL10 Pho85p cyclin recruits activates and targets Pho85p cyclin-dependent protein kinase to its substrate KLLA0B02046g 1 178646 179218 ON 2 B02046 (178646..179218) highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase GTP-binding protein of the ARF family component of COPII coat of vesicles required for transport vesicle formation during ER to Golgi protein transport KLLA0B02068g 0 179493 182996 ON 2 B02068 complement(179493..182996) similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p KLLA0B02090g 1 183718 187077 ON 2 B02090 (183718..187077) some similarities with uniprot|P53125 Saccharomyces cerevisiae YGL133W ITC1 Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex required for repression of a-specific genes repression of early meiotic genes during mitotic growth and repression of INO1 KLLA0B02112g 1 187461 188444 ON 2 B02112 (187461..188444) similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 protein required for assembly of ubiquinol cytochrome-c reductase complex KLLA0B02134g 0 188671 190221 ON 2 B02134 complement(188671..190221) similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities KLLA0B02156g 1 190619 191347 ON 2 B02156 (190619..191347) weakly similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP disruption causes reduced U2 snRNP levels physically interacts with Msl1p putative homolog of human U2A' snRNP protein KLLA0B02178g 0 191448 195965 ON 2 B02178 complement(191448..195965) similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 22% sequence identity with S. pombe Snt2 KLLA0B02200g 1 196341 197741 ON 2 B02200 (196341..197741) highly similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit KLLA0B02222g 0 197850 199157 ON 2 B02222 complement(197850..199157) similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit KLLA0B02244g 0 199514 201175 ON 2 B02244 complement(199514..201175) similar to uniprot|Q12211 Saccharomyces cerevisiae YPL212C PUS1 Involved in tRNA biogenesis intranuclear protein which exhibits a nucleotide-specific intron- dependent tRNA pseudouridine synthase activity KLLA0B02266g 1 201752 202297 ON 2 B02266 (201752..202297) highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis KLLA0B02288g 0 202601 204517 ON 2 B02288 complement(202601..204517) weakly similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane KLLA0B02310g 1 205046 206800 ON 2 B02310 (205046..206800) similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial RNA helicase plays an essential role in mitochondrial function KLLA0B02332g 0 206863 207948 ON 2 B02332 complement(206863..207948) similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase involved in regulating kinetochore-microtubule attachments associates with Sli5p which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle potential Cdc28p substrate KLLA0B02354g 1 208684 210468 ON 2 B02354 (208684..210468) similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W KLLA0B02376g 1 210877 211275 ON 2 B02376 (210877..211275) no similarity KLLA0B02398g 0 211618 212844 ON 2 B02398 complement(211618..212844) conserved hypothetical protein KLLA0B02420g 1 213115 214626 ON 2 B02420 (213115..214626) similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase mannosylates Man2GlcNAc2- PP-Dol to form Man3GlcNAc2-PP-Dol which is a precursor required for asparagine-linked protein glycosylation KLLA0B02442g 0 214743 216218 ON 2 B02442 complement(214743..216218) some similarities with uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SaGa associated Factor 73kDa Probable 73KkDa Subunit of SAGA histone acetyltransferase complex KLLA0B02464g 0 216794 217747 ON 2 B02464 complement(216794..217747) similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C Endoplasmic reticulum protein of unknown function Klac_YGOB_Anc_6.216a 0 218175 219223 ON 2 Anc_6.216a complement(218175..218813,218819..219223) ANNOTATED BY YGOB - Klac_YGOB_Anc_6.216 0 218175 219223 OFF 2 Anc_6.216 complement(218175..218813,218819..219223) ANNOTATED BY YGOB - KLLA0B02519g 1 219931 221025 ON 2 B02519 (219931..221025) similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis interacts with Kic1p and Sog2p localizes to sites of polarized growth during budding and during the mating response KLLA0B02541g 0 221104 222636 ON 2 B02541 complement(221104..222636) similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome KLLA0B02563g 0 222951 225377 ON 2 B02563 complement(222951..225377) similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Homolog of the human adrenoleukodystrophy transporter forms a heterodimer with Pxa1p of two half ATP- binding cassette transporters in the peroxisome membrane peroxisomal ABC transporter 2 KLLA0B02585g 1 226764 227561 ON 2 B02585 (226764..227561) similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud KLLA0B02607g 0 228049 230112 ON 2 B02607 complement(228049..230112) weakly similar to uniprot|P34231 Saccharomyces cerevisiae YKL187C and weakly similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W KLLA0B02629g 0 231874 232410 ON 2 B02629 complement(231874..232410) similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator essential nuclear protein Mex67p and Mtr2p form a mRNA export complex which binds to RNA KLLA0B02651g 1 233553 234935 ON 2 B02651 (233553..234935) weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription mRNA is localized and translated in the distal tip of anaphase cells resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression potential Cdc28p substrate KLLA0B02673g 1 235478 236803 ON 2 B02673 (235478..236803) similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Rate limiting step of polyamine biosynthesis pathway Ornithine decarboxylase KLLA0B02695g 1 237221 238120 ON 2 B02695 (237221..238120) similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function gene expression increases in cultures shifted to a lower temperature KLLA0B02717g 1 240125 246268 ON 2 B02717 (240125..246268) highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains acetyltransacylase dehydratase enoyl reductase malonyl transacylase and palmitoyl transacylase activities KLLA0B02739g 0 246730 247590 ON 2 B02739 complement(246730..247590) similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W KLLA0B02783g 1 248299 249552 ON 2 B02783 (248299..249552) highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of five related enzymes which are active as heteromultimeric complexes KLLA0B02805g 0 250482 253904 ON 2 B02805 complement(250482..253904) similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Homologous to S. pombe asp1 KLLA0B02827g 1 254447 257275 ON 2 B02827 (254447..257275) highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data KLLA0B02849g 0 257299 260280 ON 2 B02849 complement(257299..260280) similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Protein involved in vacuolar morphogenesis KLLA0B02871g 1 260566 260880 ON 2 B02871 (260566..260880) similar to YLR408c KLLA0B02893g 0 261089 261781 ON 2 B02893 complement(261089..261781) similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery KLLA0B02915g 0 262455 263420 ON 2 B02915 complement(262455..263420) similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 KLLA0B02937g 1 264277 265190 ON 2 B02937 (264277..264333,264903..265190) highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W RPL31A and to YLR406C uniprot|P04649 Saccharomyces cerevisiae YLR406C RPL31B, Protein component of the large (60S) ribosomal subunit KLLA0B02959g 0 266267 267322 ON 2 B02959 complement(266267..267322) highly similar to uniprot|Q757D8 Ashbya gossypii AER075W AER075Wp and similar to YLR405W uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus3p KLLA0B02981g 0 267798 269789 ON 2 B02981 complement(267798..269789) similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on L4 and L79) contains RING finger domain KLLA0B03003g 1 270824 273865 ON 2 B03003 (270824..273865) weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W KLLA0B03025g 0 274064 274762 ON 2 B03025 complement(274064..274762) weakly similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W KLLA0B03047g 0 275298 277343 ON 2 B03047 complement(275298..277343) similar to uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that integrates information from nutrient- and stress-responsive signaling pathways to help control ribosomal protein gene expression inhibits nuclear protein localization when present in multiple copies KLLA0B03069g 1 278510 280507 ON 2 B03069 (278510..280507) similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus1p and Dus4p contains a consensus oleate response element (ORE) in its promoter region KLLA0B03091g 0 280664 281398 ON 2 B03091 complement(280664..281398) similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein KLLA0B03113g 1 282503 284488 ON 2 B03113 (282503..284488) similar to uniprot|P35817 Saccharomyces cerevisiae YLR399C BDF1 Protein involved in transcription initiation at TATA-containing promoters associates with the basal transcription factor TFIID contains two bromodomains corresponds to the C-terminal region of mammalian TAF1 redundant with Bdf2p KLLA0B03135g 1 285346 286728 ON 2 B03135 (285346..286728) uniprot|Q9Y761 Kluyveromyces lactis KLLA0B03135g GNT1 Glucose N-acetyltransferase 1-A KLLA0B03157g 1 287677 288663 ON 2 B03157 (287677..288663) uniprot|Q00974 Kluyveromyces lactis KLLA0B03157g YEA4 UDP-N-acetylglucosamine transporter YEA4 KLLA0B03179g 1 289199 292204 ON 2 B03179 (289199..292204) similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 blocks translation of non-poly(A) mRNAs antiviral protein putative helicase KLLA0B03212g 0 293080 293682 ON 2 B03212 complement(293080..293682) conserved hypothetical protein KLLA0B03234g 1 293919 296333 ON 2 B03234 (293919..296333) similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family forms a hexameric complex may be involved in degradation of aberrant mRNAs KLLA0B03267g 1 296600 298519 ON 2 B03267 (296600..298519) weakly similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 vacuolar sorting protein essential for vacuolar morphogenesis and function involved in vacuolar protein targeting KLLA0B03289g 0 299377 299559 ON 2 B03289 complement(299377..299559) highly similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain KLLA0B03311g 1 300590 300811 ON 2 B03311 (300590..300811) highly similar to uniprot|Q757F1 Ashbya gossypii AER062C AER062Cp and similar to YLR395C uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain KLLA0B03333g 0 301536 302480 ON 2 B03333 complement(301536..302480) some similarities with uniprot|Q06032 Saccharomyces cerevisiae YLR394W CST9 Protein required for synaptonemal complex formation may have a role in meiotic recombination localizes to synapsis initiation sites on meiotic chromosomes potential Cdc28p substrate KLLA0B03355g 1 303444 304733 ON 2 B03355 (303444..304733) highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase catalyzes the oxidation of isocitrate to alpha-ketoglutarate not required for mitochondrial respiration and may function to divert alpha- ketoglutarate to biosynthetic processes KLLA0B03377g 1 305323 306120 ON 2 B03377 (305323..306120) highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P- Man) synthase of the ER membrane catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man required for glycosyl phosphatidylinositol membrane anchoring O mannosylation and protein glycosylation Klac_YGOB_Anc_7.541 1 306623 309832 ON 2 Anc_7.541 (306623..309832) ANNOTATED BY YGOB - KLLA0B03432g 1 311810 313864 ON 2 B03432 (311810..313864) some similarities with uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Phosphorylated protein that interacts with Vac8p required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy KLLA0B03454g 0 314015 315433 ON 2 B03454 complement(314015..315433) similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA) with putative Zn-fingers KLLA0B03476g 1 315833 316440 ON 2 B03476 (315833..315852,315984..316440) highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit KLLA0B03498g 0 316552 317016 ON 2 B03498 complement(316552..317016) similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin Myo1p binds to an IQ motif of Myo1p localization to the bud neck depends on Myo1p involved in the disassembly of the Myo1p ring KLLA0B03520g 1 317409 321614 ON 2 B03520 (317409..321614) similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 dsRNA virus protection family member contains 8 copies of the tetratricopeptide (TPR) domain KLLA0B03542g 0 321676 323649 ON 2 B03542 complement(321676..323649) similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82 KLLA0B03564g 1 324536 325618 ON 2 B03564 (324536..325618) similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 40 kDa ubiquinol cytochrome-c reductase core protein 2 KLLA0B03586g 0 326871 329075 ON 2 B03586 complement(326871..329075) similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 protein kinase involved in growth control may be redundant with cAMP pathway cAMP-dependent protein kinase homolog suppressor of cdc25ts KLLA0B03608g 0 329891 332185 ON 2 B03608 complement(329891..332185) similar to uniprot|P38888 Saccharomyces cerevisiae YHR204W MNL1 Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides KLLA0B03652g 1 332993 334215 ON 2 B03652 (332993..333006,333444..334215) highly similar to uniprot|P05753 Saccharomyces cerevisiae YJR145C RPS4A or to YHR203C uniprot|P05753 Saccharomyces cerevisiae YHR203C RPS4B KLLA0B03674g 0 334364 336277 ON 2 B03674 complement(334364..336277) similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Klac_2.trna2V 0 336352 336424 ON 2 tV-CAC complement(336352..336424) tRNA Type: Val (V) | Anti-Codon: CAC | Cove Score: 80.22 KLLA0B03718g 1 336976 337842 ON 2 B03718 (336976..337842) conserved hypothetical protein KLLA0B03740g 0 337996 338784 ON 2 B03740 complement(337996..338784) uniprot|Q00970 Kluyveromyces lactis KLLA0B03740g MGM101 Mitochondrial genome maintenance protein MGM101 mitochondrial precursor KLLA0B03762g 1 339424 341742 ON 2 B03762 (339424..341742) similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase KLLA0B03784g 0 341886 342914 ON 2 B03784 complement(341886..342914) similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W KLLA0B03806g 1 343108 344259 ON 2 B03806 (343108..344259) similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol plasma membrane and mitochondrial matrix KLLA0B03828g 0 344307 345371 ON 2 B03828 complement(344307..345371) weakly similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W essential protein KLLA0B03850g 1 345635 350590 ON 2 B03850 (345635..350590) similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Transcriptional corepressor KLLA0B03872g 1 350966 352175 ON 2 B03872 (350966..350999,351127..352175) similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions KLLA0B03894g 0 352195 356871 ON 2 B03894 complement(352195..356871) similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1 KLLA0B03916g 0 357312 358055 ON 2 B03916 complement(357312..358055) similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome KLLA0B03927g 1 358538 358786 ON 2 B03927 (358538..358786) no similarity KLLA0B03938g 1 359757 363440 ON 2 B03938 (359757..363440) similar to sp|P47169 Saccharomyces cerevisiae YJR137c ECM17 Sulfite reductase [NADPH] beta subunit involved in amino acid biosynthesis transcription repressed by methionine KLLA0B03982g 1 364575 365522 ON 2 B03982 (364575..365522) similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C FMP22 The authentic non-tagged protein was localized to the mitochondria KLLA0B04004g 0 365687 367903 ON 2 B04004 complement(365687..367903) conserved hypothetical protein KLLA0B04026g 1 368180 369463 ON 2 B04026 (368180..369463) similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C KLLA0B04048g 0 369643 369906 ON 2 B04048 complement(369643..369906) highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space import protein KLLA0B04070g 1 370262 370951 ON 2 B04070 (370262..370951) weakly similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance KLLA0B04092g 0 370977 373307 ON 2 B04092 complement(370977..373307) similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 RIbosome eXport essential protein Klac_2.trna3K 1 373654 373726 ON 2 tK-CUU (373654..373726) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 79.43 KLLA0B04136g 1 373969 375975 ON 2 B04136 (373969..375975) similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function required for wild- type growth rate on galactose and mannose localizes to COPI coated vesicles and the Golgi apparatus KLLA0B04158g 0 376098 376745 ON 2 B04158 complement(376098..376745) highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine Phosphoribosyl Transferase KLLA0B04180g 0 377179 378798 ON 2 B04180 complement(377179..378798) similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0B04202g 0 379105 382263 ON 2 B04202 complement(379105..382263) similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin a carrier protein involved in nuclear import of proteins importin beta homolog KLLA0B04224g 0 382676 383515 ON 2 B04224 complement(382676..383515) conserved hypothetical protein KLLA0B04246g 0 383847 385640 ON 2 B04246 complement(383847..385640) similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial Distribution and Morphology Klac_2.trna4F 1 386048 386120 ON 2 tF-GAA (386048..386120) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 76.93 KLLA0B04290g 1 386351 386881 ON 2 B04290 (386351..386881) similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation associated with cytoplasmic ribosomes KLLA0B04312g 0 386963 387796 ON 2 B04312 complement(386963..387796) similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W KLLA0B04334g 1 388079 388480 ON 2 B04334 (388079..388480) similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion KLLA0B04356g 0 388545 390200 ON 2 B04356 complement(388545..390200) similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1 2-mannosidase involved in N-linked oligosaccharide biosynthesis catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc integral to the ER membrane KLLA0B04378g 1 390701 392767 ON 2 B04378 (390701..392767) similar to uniprot|P47164 Saccharomyces cerevisiae YJR130C STR2 Cystathionine gamma-synthase converts cysteine into cystathionine KLLA0B04400g 0 393246 393422 ON 2 B04400 complement(393246..393422) similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase KLLA0B04422g 1 394524 395585 ON 2 B04422 (394524..395585) similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase KLLA0B04444g 1 395811 396737 ON 2 B04444 (395811..396737) similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0B04455g 1 396805 397698 ON 2 B04455 (396805..397698) no similarity KLLA0B04466g 1 398179 398415 ON 2 B04466 (398179..398415) conserved hypothetical protein KLLA0B04477g 1 400019 404017 ON 2 B04477 (400019..404017) similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W KLLA0B04499g 1 404546 405823 ON 2 B04499 (404546..405823) similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase member of a widespread family of conserved proteins including Smm1p Dus3p and Dus4p modifies pre-tRNA(Phe) at U17 KLLA0B04521g 1 406174 406806 ON 2 B04521 (406174..406806) similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Uncharacterized protein with structural resemblance to plant storage and ligand binding proteins (canavalin glycinin auxin binding protein) and also to some plant and bacterial enzymes (epimerase germin) KLLA0B04543g 1 407088 409415 ON 2 B04543 (407088..409415) similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 KLLA0B04565g 1 409720 410298 ON 2 B04565 (409720..410298) highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria KLLA0B04587g 1 411097 412299 ON 2 B04587 (411097..412299) similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p KLLA0B04609g 1 412600 413134 ON 2 B04609 (412600..412633,412731..413134) similar to uniprot|Q03630 Saccharomyces cerevisiae YML077w BET5 involved in targeting and fusion of ER to golgi transport vesicles singleton KLLA0B04620g 0 413129 415888 ON 2 B04620 complement(413129..415888) similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 zinc finger transcription factor KLLA0B04642g 0 417088 420306 ON 2 B04642 complement(417088..420306) similar to uniprot|P12683 Saccharomyces cerevisiae YML075C HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate which is a rate-limiting step in sterol biosynthesis localizes to the nuclear envelope overproduction induces the formation of karmellae KLLA0B04664g 0 421574 422830 ON 2 B04664 complement(421574..422830) highly similar to uniprot|Q06205 Saccharomyces cerevisiae and to YML074c uniprot|P38911 Saccharomyces cerevisiae KLLA0B04686g 0 423406 424620 ON 2 B04686 complement(423406..423924,424612..424620) highly similar to uniprot|P05739 Saccharomyces cerevisiae YLR448W KLLA0B04708g 0 425404 429876 ON 2 B04708 complement(425404..429876) similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Contains three calcium and lipid binding domains localized to the bud green fluorescent protein (GFP)-fusion protein localizes to the cell periphery mRNA is targeted to the bud via the mRNA transport system involving She2p C-terminal portion of Tcb1p Tcb2p and Tcb3p interact KLLA0B04730g 0 430341 431597 ON 2 B04730 complement(430341..431597) similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex KLLA0B04752g 1 432210 433253 ON 2 B04752 (432210..433253) highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 vacuolar ATPase V0 domain subunit d KLLA0B04774g 0 433472 436759 ON 2 B04774 complement(433472..436759) conserved hypothetical protein KLLA0B04796g 1 438316 438900 ON 2 B04796 (438316..438900) some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis KLLA0B04818g 0 438908 439402 ON 2 B04818 complement(438908..439402) conserved hypothetical protein KLLA0B04840g 1 439864 442179 ON 2 B04840 (439864..442179) conserved hypothetical protein KLLA0B04862g 1 442398 443591 ON 2 B04862 (442398..443591) conserved hypothetical protein KLLA0B04884g 1 443932 445689 ON 2 B04884 (443932..445689) highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase required for detoxification of dihydroxyacetone (DHA) involved in stress adaptation KLLA0B04906g 1 446132 447799 ON 2 B04906 (446132..447799) highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 facilitates RNA Polymerase II transcription elongation KLLA0B04928g 0 449470 450006 ON 2 B04928 complement(449470..450006) some similarities with uniprot|Q06201 Saccharomyces cerevisiae YLR445W Hypothetical ORF KLLA0B04950g 0 450251 451397 ON 2 B04950 complement(450251..451245,451367..451397) similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein in COPII-coated vesicles KLLA0B04972g 0 451695 452831 ON 2 B04972 complement(451695..452831) weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Spore Membrane Assembly KLLA0B04994g 0 453048 454244 ON 2 B04994 complement(453048..454244) similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 KLLA0B05016g 1 454717 457377 ON 2 B05016 (454717..457377) uniprot|P54788 Kluyveromyces lactis KLLA0B05016g ORC1 Origin recognition complex subunit 1 KLLA0B05038g 0 457608 458279 ON 2 B05038 complement(457608..458279) similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 Gtp-binding protein of the ras superfamily involved in termination of M-phase GTP-binding protein RAS superfamily KLLA0B05060g 1 459171 459938 ON 2 B05060 (459171..459938) highly similar to uniprot|P23248 Saccharomyces cerevisiae RPS1B and uniprot|P33442 Saccharomyces cerevisiae YLR441C RPS1A Ribosomal protein 10 (rp10) of the small (40S) subunit KLLA0B05082g 0 460262 461326 ON 2 B05082 complement(460262..461326) conserved hypothetical protein KLLA0B05115g 1 461624 463642 ON 2 B05115 (461624..463642) similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Protein of unknown function proposed to be involved in protein secretion KLLA0B05137g 0 463716 466334 ON 2 B05137 complement(463716..466334) similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase involved in telomere formation and elongation acts as a catalytic inhibitor of telomerase also plays a role in repair and recombination of mitochondrial DNA KLLA0B05159g 1 466882 468075 ON 2 B05159 (466882..468075) similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7 8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA repairs oxidative damage to mitochondrial DNA KLLA0B05181g 0 468267 469265 ON 2 B05181 complement(468267..469265) similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit KLLA0B05203g 1 469929 470180 ON 2 B05203 (469929..470180) similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay KLLA0B05225g 0 470465 474790 ON 2 B05225 complement(470465..474790) similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase that deacylates exogenous lysophospholipids homolog of human neuropathy target esterase (NTE) mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine KLLA0B05247g 0 475265 476578 ON 2 B05247 complement(475265..476578) highly similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse) catalyzes the second step of arginine degradation expression is dually-regulated by allophanate induction and a specific arginine induction process not nitrogen catabolite repression sensitive KLLA0B05269g 1 477175 477609 ON 2 B05269 (477175..477609) similar to uniprot|Q6HIN8 Bacillus thuringiensis subsp BT9727_2262 Hypothetical protein KLLA0B05379g 1 482011 482346 ON 2 B05379 (482011..482346) no similarity KLLA0B05423g 1 483167 483643 ON 2 B05423 (483167..483643) weakly similar to uniprot|O13577 Saccharomyces cerevisiae YLR437C KLLA0B05445g 1 484297 487248 ON 2 B05445 (484297..487248) some similarities with uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Non-essential protein of unknown function KLLA0B05467g 0 487353 487982 ON 2 B05467 complement(487353..487982) similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing KLLA0B05489g 1 488386 490023 ON 2 B05489 (488386..490023) similar to uniprot|P14747 Saccharomyces cerevisiae YML057W CMP2 calmodulin binding protein and to YLR433C uniprot|P23287 Saccharomyces cerevisiae YLR433C CNA1 calmodulin binding protein KLLA0B05511g 0 490221 492157 ON 2 B05511 complement(490221..491335,491701..492157) highly similar to uniprot|P50094 Saccharomyces cerevisiae IMD4 or to YLR432W uniprot|P50095 Saccharomyces cerevisiae IMD3 or to YHR216W uniprot|P38697 Saccharomyces cerevisiae IMD2, Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation KLLA0B05533g 1 493517 494797 ON 2 B05533 (493517..494797) weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway KLLA0B05555g 0 494997 500990 ON 2 B05555 complement(494997..500990) similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Nuclear protein putative helicase required for processing of tRNAs rRNAs and small nuclear RNAs potential Cdc28p substrate KLLA0B05577g 0 501690 505355 ON 2 B05577 complement(501690..505355) highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C KLLA0B05599g 1 506136 506861 ON 2 B05599 (506136..506861) similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit KLLA0B05621g 0 507613 508227 ON 2 B05621 complement(507613..508227) similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W KLLA0B05643g 1 509019 509359 ON 2 B05643 (509019..509045,509123..509359) highly similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes KLLA0B05665g 1 510167 512752 ON 2 B05665 (510167..512752) highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS) interacts with nucleoporins to guide transport across the nuclear pore complex KLLA0B05687g 1 513579 514274 ON 2 B05687 (513579..514274) similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER cleaves the anhydride linkage in Dol-P-P required for Dol-P-P- linked oligosaccharide intermediate synthesis and protein N-glycosylation KLLA0B05709g 0 514421 516064 ON 2 B05709 complement(514421..516064) similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W KLLA0B05742g 0 516562 517560 ON 2 B05742 complement(516562..516926,517542..517560) highly similar to uniprot|P05743 Saccharomyces cerevisiae YLR344W Klac_2.trna5R 0 518344 518415 ON 2 tR-CCG complement(518344..518415) tRNA Type: Arg (R) | Anti-Codon: CCG | Cove Score: 55.51 KLLA0B05786g 1 519156 519860 ON 2 B05786 (519156..519860) similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C FMP17 The authentic non-tagged protein was localized to the mitochondria KLLA0B05808g 0 520133 521713 ON 2 B05808 complement(520133..521713) similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p KLLA0B05841g 0 522241 527877 ON 2 B05841 complement(522241..527877) highly similar to uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 Catalytic subunit of 1 3-beta-D- glucan synthase functionally redundant with alternate catalytic subunit Gsc2p binds to regulatory subunit Rho1p involved in cell wall synthesis and maintenance localizes to sites of cell wall remodeling or uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 KLLA0B05863g 0 529188 530222 ON 2 B05863 complement(529188..530222) similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W KLLA0B05885g 0 530762 532738 ON 2 B05885 complement(530762..532738) conserved hypothetical protein KLLA0B05918g 0 533071 534006 ON 2 B05918 complement(533071..534006) highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302 KLLA0B05973g 1 534679 535140 ON 2 B05973 (534679..535140) similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0B05995g 1 535752 537224 ON 2 B05995 (535752..537224) conserved hypothetical protein Klac_2.trna6D 0 537328 537399 ON 2 tD-GUC complement(537328..537399) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 KLLA0B06039g 1 538539 540308 ON 2 B06039 (538539..540308) some similarities with YLR337C uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Involved in cytoskeletal organization and cellular growth Proline-rich protein verprolin KLLA0B06061g 0 540386 541086 ON 2 B06061 complement(540386..540917,541004..541086) similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space has a role in the maturation of cytosolic iron-sulfur proteins ortholog of human hepatopoietin (ALR) KLLA0B06094g 0 541408 542490 ON 2 B06094 complement(541408..542490) highly similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria putative membrane- spanning ATPase KLLA0B06116g 1 543019 546174 ON 2 B06116 (543019..546174) some similarities with uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Suppressor of Glycerol Defect may be involved in high osmolarity signaling pathway KLLA0B06138g 0 546274 548259 ON 2 B06138 complement(546274..548259) weakly similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Protein involved in nucleocytoplasmic transport binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels also has a role in chromatin organization Klac_2.trna7E 0 548598 548669 ON 2 tE-CUC complement(548598..548669) tRNA Type: Glu (E) | Anti-Codon: CUC | Cove Score: 69.05 KLLA0B06182g 1 549795 550121 ON 2 B06182 (549795..550121) similar to uniprot|Q3E792 Saccharomyces cerevisiae YGR027C KLLA0B06215g 0 551524 552330 ON 2 B06215 complement(551524..552330) similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery KLLA0B06237g 1 552909 553622 ON 2 B06237 (552909..553622) highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage essential enzyme conserved among eukaryotes KLLA0B06259g 0 553658 554782 ON 2 B06259 complement(553658..554782) conserved hypothetical protein Klac_2.trna8D 0 555004 555075 ON 2 tD-GUC complement(555004..555075) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 KLLA0B06303g 0 555780 559391 ON 2 B06303 complement(555780..559391) highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I subunit A135 Klac_2.trna9K 1 559891 559963 ON 2 tK-CUU (559891..559963) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 79.43 KLLA0B06347g 1 561565 562311 ON 2 B06347 (561565..562311) some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization KLLA0B06369g 1 562846 563661 ON 2 B06369 (562846..563661) similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential nuclear protein putative spliceosomal component involved in mRNA splicing based on computational analysis of large-scale protein-protein interaction data KLLA0B06391g 1 563851 564816 ON 2 B06391 (563851..564816) similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Protein of unknown function localizes to lipid particles KLLA0B06413g 1 566429 567424 ON 2 B06413 (566429..567424) weakly similar to uniprot|P23493 Saccharomyces cerevisiae YKL093W MBR1 Protein involved in mitochondrial functions and stress response KLLA0B06435g 1 567908 570817 ON 2 B06435 (567908..570817) similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons KLLA0B06457g 0 570933 574073 ON 2 B06457 complement(570933..574073) similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns mutants exhibit random budding in all cell types KLLA0B06479g 0 575030 575935 ON 2 B06479 complement(575030..575935) uniprot|P24859 Kluyveromyces lactis KLLA0B06479g SEC14 SEC14 cytosolic factor KLLA0B06501g 0 576636 579089 ON 2 B06501 complement(576636..579089) similar to uniprot|P47116 Saccharomyces cerevisiae YJR059W PTK2 Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane enhances spermine uptake KLLA0B06523g 0 579869 582862 ON 2 B06523 complement(579869..582862) similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-family ATPase peroxin required for peroxisome biogenesis contains two 230 amino acid ATP- binding AAA cassettes upregulated in anaerobiosis Pex1p and Pex6p interact via their N-terminal AAA-cassettes KLLA0B06545g 1 583095 583541 ON 2 B06545 (583095..583541) highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin- associated adaptor complex AP-2 which is involved in protein sorting at the plasma membrane related to the sigma subunit of the mammalian plasma membrane clathrin- associated protein (AP-2) complex KLLA0B06556g 0 583538 584164 ON 2 B06556 complement(583538..584164) similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase functions in de novo biosynthesis of pyrimidine deoxyribonucleotides converts dTMP to dTDP and dUMP to dUTP essential for mitotic and meiotic DNA replication homologous to S. pombe Tmp1p Klac_2.trna10Y 1 584364 584462 ON 2 tY-GUA (584364..584402,584427..584462) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.95 KLLA0B06622g 1 584889 586415 ON 2 B06622 (584889..586415) uniprot|Q7Z8M5 Kluyveromyces lactis CDC14 KLLA0B06644g 0 586591 587406 ON 2 B06644 complement(586591..587406) similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication but not for its maintenance during G2 and M phases also required for postreplicative double-strand break repair interacts with Chl1p Klac_2.trna11A 1 588418 588490 ON 2 tA-AGC (588418..588490) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0B06710g 1 588821 589450 ON 2 B06710 (588821..589450) similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C KLLA0B06732g 1 589699 591504 ON 2 B06732 (589699..591504) similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 mitochondrial protein (putative) chaperone KLLA0B06754g 1 592003 593184 ON 2 B06754 (592003..593184) similar to YDR019C, uniprot|P48015 Saccharomyces cerevisiae YDR019C (GCV1), KLLA0B06776g 1 594172 595938 ON 2 B06776 (594172..595938) similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p KLLA0B06798g 1 596500 598491 ON 2 B06798 (596500..598491) similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter required for resistance to quinidine barban cisplatin and bleomycin member of the major facilitator superfamily of transporters conferring multiple drug resistance (MFS-MDR) KLLA0B06820g 1 598869 600083 ON 2 B06820 (598869..600083) similar to uniprot|P38226 Saccharomyces cerevisiae YBR042C KLLA0B06842g 0 600154 602181 ON 2 B06842 complement(600154..602181) similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Fatty acid transporter and very long-chain fatty acyl-CoA synthetase may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids KLLA0B06864g 0 602511 603404 ON 2 B06864 complement(602511..603404) similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating may participate in or regulate the low affinity Ca2 influx system which affects intracellular signaling and cell-cell fusion during mating KLLA0B06886g 0 604332 605201 ON 2 B06886 complement(604332..605201) uniprot|P49377 Kluyveromyces lactis KLLA0B06886g ATP3 ATP synthase gamma chain mitochondrial precursor Klac_2.trna12D 0 605768 605839 ON 2 tD-GUC complement(605768..605839) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 Klac_2.trna13R 0 605861 605932 ON 2 tR-UCU complement(605861..605932) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 KLLA0B06952g 1 606694 609378 ON 2 B06952 (606694..609378) some similarities with uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexaphosphate kinase phosphorylates inositol hexakisphosphate (InsP6) to diphosphoinositol polyphosphates required for proper vacuole morphology and involved in salt stress response contains two leucine heptad repeats KLLA0B06974g 1 610375 610662 ON 2 B06974 (610375..610662) similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore Klac_2.trna14I 1 611056 611129 ON 2 tI-AAU (611056..611129) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 KLLA0B07040g 1 613103 614116 ON 2 B07040 (613103..614116) similar to uniprot|Q08913 Saccharomyces cerevisiae YPL279C and similar to YOR390w KLLA0B07062g 1 614589 615266 ON 2 B07062 (614589..615266) highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase has homologs in E. coli and Myxococcus xanthus transcription is under the general control of nitrogen metabolism KLLA0B07084g 0 615326 617071 ON 2 B07084 complement(615326..617071) weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Protein of unknown function mutation confers radiation sensitivity KLLA0B07095g 1 617330 617965 ON 2 B07095 (617330..617965) highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery KLLA0B07117g 1 618368 619414 ON 2 B07117 (618368..619414) highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs including Npl3p and Hrp1p thus facilitating nuclear export of these proteins required for viability of npl3 mutants KLLA0B07139g 0 620003 621094 ON 2 B07139 complement(620003..621094) highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap KLLA0B07161g 0 621391 623052 ON 2 B07161 complement(621391..623052) weakly similar to uniprot|P38222 Saccharomyces cerevisiae YBR030W KLLA0B07183g 0 623544 623936 ON 2 B07183 complement(623544..623936) similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation KLLA0B07205g 0 624606 625973 ON 2 B07205 complement(624606..625973) similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C TPK3 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit and to YJL164C uniprot|P06244 Saccharomyces cerevisiae YJL164C TPK1 putative catalytic subunit of cAMP- dependent protein kinase KLLA0B07227g 0 627833 629695 ON 2 B07227 complement(627833..629695) similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C KLLA0B07249g 0 630336 633095 ON 2 B07249 complement(630336..633095) highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis multimembrane-spanning protein that localizes to the endoplasmic reticulum highly conserved among eukaryotes KLLA0B07271g 0 633724 635685 ON 2 B07271 complement(633724..635685) some similarities with uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain Klac_2.trna15N 0 635945 636018 ON 2 tN-GUU complement(635945..636018) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 Klac_2.trna16E 0 636711 636782 ON 2 tE-UUC complement(636711..636782) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0B07337g 1 637267 637788 ON 2 B07337 (637267..637788) weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161w KLLA0B07370g 0 638135 639031 ON 2 B07370 complement(638135..639031) similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats KLLA0B07392g 1 641481 642569 ON 2 B07392 (641481..642569) similar to uniprot|Q03178 Saccharomyces cerevisiae YKL164C PIR1 Protein containing tandem internal repeats Klac_2.trna17C 0 643157 643228 ON 2 tC-GCA complement(643157..643228) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 KLLA0B07447g 0 643757 644584 ON 2 B07447 complement(643757..644584) similar to uniprot|P47001 Saccharomyces cerevisiae YJL158C CIS3 cik1 suppressor Protein with homology to Hsp150p and Pir1p Pir2p and Pir3p KLLA0B07469g 0 645646 648282 ON 2 B07469 complement(645646..648282) some similarities with uniprot|P21268 Saccharomyces cerevisiae YJL157C FAR1 Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone also forms a complex with Cdc24p Ste4p and Ste18p that may specify the direction of polarized growth during mating potential Cdc28p substrate KLLA0B07491g 0 649247 651346 ON 2 B07491 complement(649247..651346) similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes KLLA0B07513g 0 652357 653727 ON 2 B07513 complement(652357..653727) highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2 6-bisphosphatase required for glucose metabolism KLLA0B07535g 0 654189 656828 ON 2 B07535 complement(654189..656828) similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Protein involved in vacuolar sorting retromer complex component KLLA0B07557g 1 657789 658829 ON 2 B07557 (657789..658829) similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase degrades reactive oxygen species in mitochondria involved in the response to oxidative stress KLLA0B07579g 1 659591 661759 ON 2 B07579 (659591..661759) similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity localizes to the nucleus and to the daughter side of the mother-bud neck homolog of S. pombe Wee1p potential Cdc28p substrate Klac_YGOB_RPL39 0 662543 662793 ON 2 RPL39 complement(662543..662692,662788..662793) ANNOTATED BY YGOB - unsure about exon 1 KLLA0B07601g 1 664026 664418 ON 2 B07601 (664026..664418) highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit KLLA0B07623g 0 664788 665958 ON 2 B07623 complement(664788..665191,665949..665958) uniprot|P27069 Kluyveromyces lactis KLLA0B07623g RPS14 40S ribosomal protein S14 KLLA0B07645g 1 666889 667593 ON 2 B07645 (666889..667593) similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 suppressor of pma1-7 KLLA0B07667g 1 667863 673862 ON 2 B07667 (667863..673862) some similarities with uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1 KLLA0B07689g 0 673884 675017 ON 2 B07689 complement(673884..675017) similar to uniprot|P39542 Saccharomyces cerevisiae YJL193W KLLA0B07711g 0 675600 677111 ON 2 B07711 complement(675600..677111) conserved hypothetical protein KLLA0B07733g 1 677879 679177 ON 2 B07733 (677879..679177) highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase aminoacylates tryptophanyl-tRNA KLLA0B07755g 0 679506 680135 ON 2 B07755 complement(679506..680135) similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3 4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) required for riboflavin biosynthesis from ribulose-5-phosphate also has an unrelated function in mitochondrial respiration KLLA0B07777g 0 681163 682191 ON 2 B07777 complement(681163..682191) similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase III synthesizes 20-26-carbon fatty acids from C18-CoA primers involved in fatty acid biosynthesis KLLA0B07799g 0 682960 686643 ON 2 B07799 complement(682960..686643) similar to uniprot|P51862 Saccharomyces cerevisiae YLR371W ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p mutations are synthetically lethal with mutations in rom1 which also encodes a GEP KLLA0B07821g 1 687701 688231 ON 2 B07821 (687701..688231) highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches KLLA0B07843g 0 688371 690308 ON 2 B07843 complement(688371..690308) similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone involved in the synthesis and assembly of iron/sulfur clusters into proteins KLLA0B07865g 0 690559 692301 ON 2 B07865 complement(690559..692301) some similarities with YLR368W MDM30 F-box protein KLLA0B07887g 1 693510 695624 ON 2 B07887 (693510..695624) similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C KLLA0B07909g 1 697885 700653 ON 2 B07909 (697885..700653) some similarities with uniprot|P53243 Saccharomyces cerevisiae YGR067C KLLA0B07931g 0 701123 702652 ON 2 B07931 complement(701123..701382,701973..702104,702652..702652) highly similar to uniprot|P04648 Saccharomyces cerevisiae YLR367W RPS22B and to uniprot|P04648 Saccharomyces cerevisiae YJL190C RPS22A Proteins component of the small (40S) ribosomal subunit KLLA0B07953g 1 703782 705578 ON 2 B07953 (703782..705578) highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 vitamin H transporter H -biotin symporter KLLA0B07975g 0 705661 705996 ON 2 B07975 complement(705661..705996) similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W KLLA0B07997g 1 706556 706864 ON 2 B07997 (706556..706864) uniprot|P81205 Kluyveromyces lactis KLLA0B07997g SPT4 Transcription elongation factor SPT4 KLLA0B08019g 1 707312 708253 ON 2 B08019 (707312..708253) uniprot|P78990 Kluyveromyces lactis KLLA0B08019g COX18 Inner membrane protein COX18 mitochondrial precursor KLLA0B08041g 0 708380 708649 ON 2 B08041 complement(708380..708649) similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A KLLA0B08063g 1 709756 713805 ON 2 B08063 (709756..713805) highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway KLLA0B08085g 0 714158 715108 ON 2 B08085 complement(714158..715108) highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants accumulate the sterol intermediate 4 4-dimethylzymosterol KLLA0B08107g 1 716305 717039 ON 2 B08107 (716305..717039) similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p may be involved in the nonsense-mediated mRNA decay pathway KLLA0B08129g 0 718086 719732 ON 2 B08129 complement(718086..719732) similar to uniprot|P41901 Saccharomyces cerevisiae YGR059W SPR3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes regulated by ABFI septin protein involved in sporulation KLLA0B08151g 0 720152 721240 ON 2 B08151 complement(720152..721240) similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W KLLA0B08173g 0 722254 722574 ON 2 B08173 complement(722254..722574) highly similar to uniprot|P46784 Saccharomyces cerevisiae YMR230W RPS10B and to uniprot|Q08745 Saccharomyces cerevisiae YOR293W RPS10A Proteins component of the small (40S) ribosomal subunit KLLA0B08195g 1 723299 724291 ON 2 B08195 (723299..724291) similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C KLLA0B08217g 0 724364 728683 ON 2 B08217 complement(724364..728683) similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W KLLA0B08239g 1 729850 735039 ON 2 B08239 (729850..735039) similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 Part of small ribosomal subunit (SSU) processosome containing U3 snoRNA) required for the synthesis of both 18S and 5.8S rRNAs KLLA0B08261g 1 735279 736346 ON 2 B08261 (735279..736346) some similarities with uniprot|Q752K9 Ashbya gossypii AFR565C AFR565Cp KLLA0B08283g 0 736483 737490 ON 2 B08283 complement(736483..737490) uniprot|P87250 Kluyveromyces lactis KLLA0B08283g MTF1 Mitochondrial replication protein MTF1 KLLA0B08305g 1 737967 740174 ON 2 B08305 (737967..740174) some similarities with uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa) involved in RNA polymerase II transcription initiation KLLA0B08327g 1 742205 746809 ON 2 B08327 (742205..746809) similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 involved in the coordinate regulation of phospholipid synthesis transcriptional regulator Klac_2.trna18T 1 747257 747329 ON 2 tT-AGU (747257..747329) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 KLLA0B08371g 0 747517 748323 ON 2 B08371 complement(747517..748323) highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP( )-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids Klac_2.trna19A 0 749006 749078 ON 2 tA-UGC complement(749006..749078) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 76.57 KLLA0B08415g 1 749520 749885 ON 2 B08415 (749520..749885) similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C KLLA0B08437g 0 750194 750652 ON 2 B08437 complement(750194..750652) highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase involved in salvage pathways of pyrimidine metabolism KLLA0B08459g 1 751178 752065 ON 2 B08459 (751178..752065) similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C JID1 Probable Hsp40p co-chaperone has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain inhibits replication of Brome mosaic virus in S. cerevisiae KLLA0B08481g 1 752482 753264 ON 2 B08481 (752482..753264) highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis KLLA0B08503g 0 753498 754409 ON 2 B08503 complement(753498..754409) similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family KLLA0B08525g 0 754935 755915 ON 2 B08525 complement(754935..755915) weakly similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs required for pre-mRNA splicing and snRNP biogenesis in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed KLLA0B08547g 1 756147 756512 ON 2 B08547 (756147..756512) conserved hypothetical protein KLLA0B08569g 0 756558 757571 ON 2 B08569 complement(756558..757571) similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W KLLA0B08591g 1 758017 762252 ON 2 B08591 (758017..762252) similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Klac_2.trna20N 1 762452 762525 ON 2 tN-GUU (762452..762525) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 KLLA0B08635g 1 762767 764416 ON 2 B08635 (762767..764416) similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C KLLA0B08657g 1 764962 767337 ON 2 B08657 (764962..767337) uniprot|Q9Y787 Kluyveromyces lactis KLLA0B08657g PET111 COX2 mRNA-specific translational activator Pet111 KLLA0B08679g 1 767808 768899 ON 2 B08679 (767808..768899) weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 Nuclear protein putative RNA polymerase II elongation factor isolated as Pob3p/Spt16p- binding protein KLLA0B08712g 1 769252 769440 ON 2 B08712 (769252..769440) highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain KLLA0B08734g 1 770125 771147 ON 2 B08734 (770125..771147) similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W KLLA0B08756g 0 771322 771966 ON 2 B08756 complement(771322..771966) conserved hypothetical protein KLLA0B08778g 1 772247 772606 ON 2 B08778 (772247..772606) similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C KLLA0B08800g 0 772732 774444 ON 2 B08800 complement(772732..774444) similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase KLLA0B08822g 1 775550 777016 ON 2 B08822 (775550..777016) highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Probable regulator of glucose influx into the cell & into glycolytic pathway indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein 56 kD synthase subunit of trehalose-6-phosphate synthase/phosphatase complex KLLA0B08844g 1 777472 778674 ON 2 B08844 (777472..778674) similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity KLLA0B08866g 1 779130 780962 ON 2 B08866 (779130..780962) similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C subunit of the RNA polymerase III transcription initiation factor complex (TFIIIC) KLLA0B08888g 1 781251 781766 ON 2 B08888 (781251..781766) similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit KLLA0B08910g 1 782025 782456 ON 2 B08910 (782025..782456) highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 component of the U4/U6aU5 tri- snRNP KLLA0B08932g 1 783004 784995 ON 2 B08932 (783004..784995) highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C GRS1 glycyl-tRNA synthase KLLA0B08954g 1 785408 785878 ON 2 B08954 (785408..785878) similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Translational activator of COB mRNA KLLA0B08976g 0 786122 787039 ON 2 B08976 complement(786122..787039) similar to uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein homolog of human U1-A involved in nuclear mRNA splicing KLLA0B08998g 0 787497 788873 ON 2 B08998 complement(787497..788873) highly similar to uniprot|P02994 Saccharomyces cerevisiae YPR080W TEF1 functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes translational elongation factor EF-1 alpha KLLA0B09020g 0 790295 791305 ON 2 B09020 complement(790295..791305) similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein KLLA0B09042g 1 791864 792355 ON 2 B09042 (791864..792355) no similarity KLLA0B09064g 0 792849 793973 ON 2 B09064 complement(792849..793973) uniprot|P49384 Kluyveromyces lactis KLLA0B09064g ADH3 Alcohol dehydrogenase III mitochondrial precursor KLLA0B09108g 0 795534 796331 ON 2 B09108 complement(795534..796331) conserved hypothetical protein KLLA0B09130g 1 797768 799009 ON 2 B09130 (797768..799009) some similarities with sgd|S0006279 uniprot|Q6B149 Saccharomyces cerevisiae YPR075c OPY2 pheromone resistant yeast 2 KLLA0B09152g 1 800238 802277 ON 2 B09152 (800238..802277) uniprot|Q12630 Kluyveromyces lactis KLLA0B09152g TKL1 Transketolase KLLA0B09174g 1 802641 803114 ON 2 B09174 (802641..803114) similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 phosphatase KLLA0B09196g 0 803259 805031 ON 2 B09196 complement(803259..805031) similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of global transcriptional regulator KLLA0B09218g 1 805915 810072 ON 2 B09218 (805915..810072) uniprot|Q8NJ21 Kluyveromyces lactis lys2 Alpha- aminoadipate reductase KLLA0B09240g 0 810178 812574 ON 2 B09240 complement(810178..812574) highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 4 (NEF4) member of the SWI/SNF family KLLA0B09262g 1 814303 817128 ON 2 B09262 (814303..817128) highly similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co- repressor acts together with Tup1p also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters Klac_YGOB_KLLA0B09284g 0 817377 817760 ON 2 KLLA0B09284g complement(817377..817593,817687..817760) ANNOTATED BY YGOB - KLLA0B09284g 0 817377 817667 OFF 2 B09284 complement(817377..817667) similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Protein involved in mRNA export coupled transcription activation component of the SAGA histone acetylase complex KLLA0B09306g 1 818061 818732 ON 2 B09306 (818061..818732) similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C Klac_2.trna21S 0 818902 818983 ON 2 tS-UGA complement(818902..818983) tRNA Type: Ser (S) | Anti-Codon: UGA | Cove Score: 84.16 KLLA0B09350g 0 819170 820450 ON 2 B09350 complement(819170..820450) similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 transcriptional regulator KLLA0B09372g 1 821388 822269 ON 2 B09372 (821388..822269) highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 biosynthesis of spermidine putrescine aminopropyltransferase (spermidine synthase) KLLA0B09394g 1 822629 823954 ON 2 B09394 (822629..823954) similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C HOS1 Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p complex KLLA0B09405g 0 823945 825288 ON 2 B09405 complement(823945..825288) similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase in the endoplasmic reticulum KLLA0B09427g 1 825951 826394 ON 2 B09427 (825951..826394) uniprot|O60041 Kluyveromyces lactis KLLA0B09427g CMD1 Calmodulin KLLA0B09460g 0 826867 829446 ON 2 B09460 complement(826867..829446) similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W Protein interacting with Rsv167p KLLA0B09482g 1 829842 830426 ON 2 B09482 (829842..830426) no similarity KLLA0B09504g 0 830548 831120 ON 2 B09504 complement(830548..831120) similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2 KLLA0B09526g 0 831336 832277 ON 2 B09526 complement(831336..832277) similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation GFP-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0B09548g 0 832583 833155 ON 2 B09548 complement(832583..833155) highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein involved in phosphate transport KLLA0B09592g 1 834414 835415 ON 2 B09592 (834414..835415) similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 also involved in vacuolar protein targeting peripheral vesicle membrane protein Klac_2.trna22C 0 835760 835831 ON 2 tC-GCA complement(835760..835831) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 KLLA0B09636g 1 836265 836693 ON 2 B09636 (836265..836693) similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers monothiol glutaredoxin subfamily member along with Grx3p and Grx4p KLLA0B09658g 0 837873 838901 ON 2 B09658 complement(837873..838901) similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W KLLA0B09680g 0 840160 841818 ON 2 B09680 complement(840160..841818) similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W KLLA0B09702g 0 842245 846801 ON 2 B09702 complement(842245..846801) highly similar to uniprot|Q02785 Saccharomyces cerevisiae YPL058C PDR12 Plasma membrane weak-acid- inducible ATP-binding cassette (ABC) transporter required for weak organic acid resistance strongly induced by sorbate and benzoate regulated by War1p mutants exhibit sorbate hypersensitivity KLLA0B09724g 0 848785 848979 ON 2 B09724 complement(848785..848979) similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A YSY6 Protein that participates in secretory pathway KLLA0B09746g 1 850402 851775 ON 2 B09746 (850402..851775) similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Target of SBF KLLA0B09768g 0 852589 853665 ON 2 B09768 complement(852589..853665) similar to uniprot|P33300 Saccharomyces cerevisiae YPL057C SUR1 and similar to uniprot|P38287 Saccharomyces cerevisiae YBR161w CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase forms a complex with probable regulatory subunit Csg2p KLLA0B09790g 0 855327 856214 ON 2 B09790 complement(855327..856214) highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK) alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates KLLA0B09812g 0 856799 857839 ON 2 B09812 complement(856799..857839) similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W microsomal beta-keto-reductase KLLA0B09834g 0 858130 858822 ON 2 B09834 complement(858130..858822) some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function null mutant forms abnormally large cells KLLA0B09856g 0 859162 860436 ON 2 B09856 complement(859162..860436) weakly similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Involved in daughter cell separation and Chromosome STability Chromosome STability KLLA0B09878g 1 862234 863529 ON 2 B09878 (862234..863529) some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Protein of unknown function KLLA0B09900g 1 866210 867571 ON 2 B09900 (866210..867571) conserved hypothetical protein KLLA0B09922g 0 867748 870141 ON 2 B09922 complement(867748..870141) weakly similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes KLLA0B09944g 1 870678 872702 ON 2 B09944 (870678..872702) weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Mitotic spindle protein involved in chromosome segregation. KLLA0B09966g 0 872760 873872 ON 2 B09966 complement(872760..873872) similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 cyclophilin seven suppressor component of Hsp90p chaperone machinery KLLA0B09988g 0 874338 875621 ON 2 B09988 complement(874338..875621) similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W KRE2 Alpha1 2-mannosyltransferase of the Golgi involved in protein mannosylation KLLA0B10010g 0 876684 877540 ON 2 B10010 complement(876684..877423,877459..877540) similar to uniprot|P53386 Saccharomyces cerevisiae YPR192W AQY1 Water channel that mediates the transport of water across cell membranes and may be involved in freeze tolerance Klac_YGOB_OAZ1 1 879228 880047 ON 2 OAZ1 (879228..879488,879490..880047) ANNOTATED BY YGOB - Uncertain about exact site of ribosomal frameshift. Replaces KLLA0B100032g KLLA0B10032g 1 879469 880047 OFF 2 B10032 (879469..880047) conserved hypothetical protein KLLA0B10054g 1 880175 880630 ON 2 B10054 (880175..880630) similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C KLLA0B10076g 0 881077 882549 ON 2 B10076 complement(881077..882549) some similarities with uniprot|Q751G8 Ashbya gossypii AGL262C AGL262Cp KLLA0B10098g 1 884810 885301 ON 2 B10098 (884810..885301) no similarity KLLA0B10120g 1 886187 887233 ON 2 B10120 (886187..887233) some similarities with uniprot|Q06674 Saccharomyces cerevisiae YDR317W KLLA0B10142g 1 887476 888478 ON 2 B10142 (887476..887527,887649..888478) similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance component of the COMA complex that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules KLLA0B10153g 0 888468 889271 ON 2 B10153 complement(888468..889271) similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C KLLA0B10175g 1 889538 891733 ON 2 B10175 (889538..891733) highly similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase an essential enzyme that catalyzes the cyclization of squalene 2 3- epoxide a step in ergosterol biosynthesis KLLA0B10197g 0 891842 893707 ON 2 B10197 complement(891842..893707) similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 auxilin-like protein KLLA0B10219g 0 893941 894480 ON 2 B10219 complement(893941..894480) conserved hypothetical protein KLLA0B10241g 1 895841 896230 ON 2 B10241 (895841..896230) weakly similar to uniprot|Q12048 Saccharomyces cerevisiae YPL250C ICY2 Protein that interacts with the cytoskeleton and is involved in chromatin organization and nuclear transport KLLA0B10263g 1 896677 899916 ON 2 B10263 (896677..899916) similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W KLLA0B10285g 0 900197 900862 ON 2 B10285 complement(900197..900862) similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Involved in cis-Golgi membrane traffic Vti1p is a v-SNARE that interacts with two t-SNARES Sed5p and Pep12p KLLA0B10307g 1 901566 902066 ON 2 B10307 (901566..902066) similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Iron-sulfur protein of the mitochondrial matrix homologous to human adrenodoxin involved in heme a biosynthesis KLLA0B10329g 1 902691 904532 ON 2 B10329 (902691..904532) weakly similar to uniprot|Q01649 Saccharomyces cerevisiae YMR198W CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle is essential for karyogamy and expression is regulated by KAR4 and mating spindle pole body associated protein and to uniprot|Q12045 YPL253C VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule- mediated processes; required for sister chromatid cohesion KLLA0B10351g 0 904656 905954 ON 2 B10351 complement(904656..905954) similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex a histone acetyltransferase- coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions KLLA0B10373g 0 906659 908362 ON 2 B10373 complement(906659..908362) some similarities with uniprot|P33757 Saccharomyces cerevisiae YBR250W KLLA0B10395g 0 909517 910695 ON 2 B10395 complement(909517..910695) some similarities with uniprot|P33757 Saccharomyces cerevisiae YBR250W KLLA0B10406g 0 910676 911113 ON 2 B10406 complement(910676..911113) conserved hypothetical protein KLLA0B10428g 0 911707 912192 ON 2 B10428 complement(911707..912192) no similarity KLLA0B10450g 1 912877 914046 ON 2 B10450 (912877..914046) some similarities with uniprot|P41817 Saccharomyces cerevisiae YPL177C CUP9 Homeodomain-containing transcriptional repressor of PTR2 which encodes a major peptide transporter imported peptides activate ubiquitin- dependent proteolysis resulting in degradation of Cup9p and de-repression of PTR2 transcription KLLA0B10472g 0 914512 915108 ON 2 B10472 complement(914512..915108) highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p component of the spliceosomal commitment complex interacts with Npl3p possibly to package mRNA for export from the nucleus contains an RNA-binding motif Klac_2.trna23E 1 915687 915758 ON 2 tE-UUC (915687..915758) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 Klac_YGOB_Anc_6.172 0 916365 917855 ON 2 Anc_6.172 complement(916365..917855) ANNOTATED BY YGOB - KLLA0B10538g 1 919185 921380 ON 2 B10538 (919185..921380) similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 High copy suppressor of choline-transport mutants KLLA0B10560g 0 921743 923125 ON 2 B10560 complement(921743..923125) similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Suppressor of translation mutants Translation initiation factor eIF-4B KLLA0B10582g 1 924069 931958 ON 2 B10582 (924069..931958) similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 The authentic non-tagged protein was localized to the mitochondria KLLA0B10604g 1 932289 935693 ON 2 B10604 (932289..935693) conserved hypothetical protein KLLA0B10626g 1 936497 937123 ON 2 B10626 (936497..937123) uniprot|Q8J212 Kluyveromyces lactis RHO1_KLULA Protein Rho1 KLLA0B10648g 0 937752 938099 ON 2 B10648 complement(937752..938099) highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit KLLA0B10670g 0 938387 939217 ON 2 B10670 complement(938387..939217) weakly similar to uniprot|P32460 YIR030c Saccharomyces cerevisiae YIR030c DCG1 involved in nitrogen- catabolite metabolism KLLA0B10692g 0 939675 940469 ON 2 B10692 complement(939675..940469) highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase reduces 3'-phosphoadenylyl sulfate to adenosine-3' 5'- bisphosphate and free sulfite using reduced thioredoxin as cosubstrate involved in sulfate assimilation and methionine metabolism KLLA0B10714g 1 941126 941611 ON 2 B10714 (941126..941611) similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription KLLA0B10736g 1 941796 943373 ON 2 B10736 (941796..943373) similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Nucleolar protein of unknown function exhibits a physical interaction with Bre1p Klac_2.trna24I 0 943522 943595 ON 2 tI-AAU complement(943522..943595) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 KLLA0B10769g 1 943832 944321 ON 2 B10769 (943832..943849,943936..944066,944213..944321) highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B KLLA0B10780g 1 944758 946434 ON 2 B10780 (944758..946434) some similarities with uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp2p and Inp53p to the cortical actin cytoskeleton KLLA0B10802g 1 947115 948128 ON 2 B10802 (947115..948128) similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W KLLA0B10824g 1 948593 949180 ON 2 B10824 (948593..949180) similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W Protein of unknown function transcriptionally activated by Yrm1p along with genes involved in multidrug resistance KLLA0B10846g 0 949338 950630 ON 2 B10846 complement(949338..950630) highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 Defective in vacuolar protein sorting homologous to mouse SKD1 and to human hVPS4 AAA- type ATPase KLLA0B10868g 0 951111 952835 ON 2 B10868 complement(951111..952835) highly similar to uniprot|P49089 Saccharomyces cerevisiae YPR145W ASN1 Asparagine synthetase isozyme of Asn2p catalyzes the synthesis of L-asparagine from L- aspartate in the asparagine biosynthetic pathway KLLA0B10890g 1 954119 955684 ON 2 B10890 (954119..955684) similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits KLLA0B10912g 1 955948 957486 ON 2 B10912 (955948..957486) similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C KLLA0B10934g 0 957643 958404 ON 2 B10934 complement(957643..958404) some similarities with gnl|GLV|CAGL0D05016g Candida glabrata CAGL0D05016g and some similarities with YPR143W uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Essential protein involved in pre-rRNA processing KLLA0B10956g 1 958985 961057 ON 2 B10956 (958985..961057) similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis localizes to the spindle pole body and localization is dependent on functional Cik1p required for nuclear fusion during mating potential Cdc28p substrate KLLA0B10978g 0 961330 962553 ON 2 B10978 complement(961330..962553) similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W KLLA0B11000g 1 962820 963674 ON 2 B11000 (962820..963674) similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66 KLLA0B11011g 0 963671 964834 ON 2 B11011 complement(963671..964834) weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W KLLA0B11033g 1 966275 967636 ON 2 B11033 (966275..967636) similar to uniprot|P53390 Saccharomyces cerevisiae YPR138C MEP3 Ammonium permease of high capacity and low affinity belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+) expression is under the nitrogen catabolite repression regulation ammonia permease or uniprot|P40260 Saccharomyces cerevisiae YGR121C MEP1 KLLA0B11055g 1 969484 970302 ON 2 B11055 (969484..970302) some similarities with uniprot|Q12218 Saccharomyces cerevisiae YOR009W YOROO9W TIR4 protein KLLA0B11077g 0 970761 972464 ON 2 B11077 complement(970761..972464) similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) KLLA0B11099g 0 972830 975658 ON 2 B11099 complement(972830..975658) similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein required for sister chromatid cohesion interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion KLLA0B11121g 1 976252 976965 ON 2 B11121 (976252..976965) weakly similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments KLLA0B11143g 1 977257 978972 ON 2 B11143 (977257..978972) some similarities with uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Essential subunit of the nuclear pore complex (NPC) KLLA0B11165g 0 979154 979909 ON 2 B11165 complement(979154..979909) weakly similar to uniprot|P08593 YPR134W Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions KLLA0B11187g 0 980285 980434 ON 2 B11187 complement(980285..980434) similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Small mitochondrial outer membrane protein crucial to a binding relay for the import of proteins into mitochondria; subunit on the outer mouth of the TOM channel that accepts precursors from the receptors Tom20p and Tom22p KLLA0B11209g 1 980881 981969 ON 2 B11209 (980881..981969) similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C IWS1 Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II probable transcriptional elongation factor metazoan homologs contain an acidic N terminus mutations in the gene confer an Spt- phenotype KLLA0B11231g 0 982256 983313 ON 2 B11231 complement(982256..982628,983249..983313) uniprot|Q875M3 Kluyveromyces lactis KLLA0B11231g RPS23 KLLA0B11253g 1 984132 985544 ON 2 B11253 (984132..985544) similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C KLLA0B11275g 1 985951 986544 ON 2 B11275 (985951..986544) similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met KLLA0B11297g 0 986720 987610 ON 2 B11297 complement(986720..987610) some similarities with uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain may bind RNA and have a role in RNA processing overproduction suppresses a null mutation in CHC1 which encodes the heavy chain of clathrin KLLA0B11319g 1 988293 989360 ON 2 B11319 (988293..989360) similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter involved in beta-oxidation of medium-chain fatty acid required for peroxisome proliferation KLLA0B11341g 0 989629 991008 ON 2 B11341 complement(989629..991008) similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W KLLA0B11363g 0 991730 992548 ON 2 B11363 complement(991730..992548) some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase KLLA0B11385g 0 993418 997800 ON 2 B11385 complement(993418..997800) similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation KLLA0B11407g 0 998343 999251 ON 2 B11407 complement(998343..999251) similar to uniprot|Q75EP9 Ashbya gossypii AAR030W AAR030Wp and some similarites with YPR124W uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane mediates nearly all copper uptake under low copper conditions transcriptionally induced at low copper levels and degraded at high copper levels KLLA0B11429g 0 999890 1000831 ON 2 B11429 complement(999890..1000831) some similarities with uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Component of the DASH complex localized to intranuclear spindles and spindle pole bodies interacts with Duo1p and Mps1p key Ipl1p target for regulating kinetochore-microtubule attachments KLLA0B11451g 0 1001315 1002427 ON 2 B11451 complement(1001315..1002427) similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W KLLA0B11473g 0 1002808 1003692 ON 2 B11473 complement(1002808..1003692) similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit KLLA0B11495g 0 1006306 1007487 ON 2 B11495 complement(1006306..1007487) similar to uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes contains an HMG domain that is responsible for DNA bending activity Klac_YGOB_Anc_7.168b 1 1011211 1013552 ON 2 Anc_7.168b (1011211..1012701,1012704..1013552) ANNOTATED BY YGOB - Klac_YGOB_Anc_7.168 1 1011211 1012734 OFF 2 Anc_7.168 (1011211..1012734) ANNOTATED BY YGOB - KLLA0B11550g 0 1013848 1014678 ON 2 B11550 complement(1013848..1014678) similar to gnl|GLV|CAGL0H09438g Candida glabrata CAGL0H09438g and weakly similar to YER016W uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally KLLA0B11572g 0 1015091 1017328 ON 2 B11572 complement(1015091..1017328) similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Long chain fatty acyl-CoA synthetase accepts a wider range of acyl chain lengths than Faa1p preferring C9:0-C13:0 involved in the activation of endogenous pools of fatty acids KLLA0B11594g 0 1018044 1018388 ON 2 B11594 complement(1018044..1018388) similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP involved in splicing binds the U2 snRNA stem-loop IV in vitro does not contain the conserved C-terminal RNA binding domain found in other family members KLLA0B11616g 0 1018695 1020305 ON 2 B11616 complement(1018695..1020305) similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway converting protoporphyrinogen IX to protoporphyrin IX KLLA0B11638g 0 1020591 1023926 ON 2 B11638 complement(1020591..1023926) similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 RNA-dependent ATPase/ATP-dependent RNA helicase in the DEAH-box family associates with the lariat intermediate before the second catalytic step of splicing KLLA0B11660g 0 1024265 1024852 ON 2 B11660 complement(1024265..1024852) highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 20S proteasome beta-type subunit localizes to the nucleus throughout the cell cycle KLLA0B11682g 0 1025244 1026554 ON 2 B11682 complement(1025244..1026554) highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair KLLA0B11704g 0 1026886 1029105 ON 2 B11704 complement(1026886..1029105) similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Klac_2.trna25E 0 1029478 1029549 ON 2 tE-UUC complement(1029478..1029549) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0B11748g 0 1030050 1031855 ON 2 B11748 complement(1030050..1031855) similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial Distribution and Morphology KLLA0B11770g 1 1032369 1032998 ON 2 B11770 (1032369..1032998) weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W KLLA0B11792g 1 1033135 1033698 ON 2 B11792 (1033135..1033698) similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends not shared between Rnase MRP and Rnase P in contrast to all other Rnase P protein subunits KLLA0B11814g 0 1033801 1034298 ON 2 B11814 complement(1033801..1034298) some similarities with uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein that mediates assembly of mitochondrial beta- barrel proteins also proposed to be involved in mitochondrial import KLLA0B11836g 1 1034800 1035564 ON 2 B11836 (1034800..1035564) highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 20S proteasome alpha-type subunit KLLA0B11858g 1 1036159 1038522 ON 2 B11858 (1036159..1038522) weakly similar to uniprot|Q08206 Saccharomyces cerevisiae YOL036W Protein of unknown function potential Cdc28p substrate KLLA0B11880g 0 1039145 1040059 ON 2 B11880 complement(1039145..1040059) weakly similar to uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Transcriptional activator in the Cbf1p-Met4p-Met28p complex participates in the regulation of sulfur metabolism KLLA0B11902g 1 1041657 1043144 ON 2 B11902 (1041657..1043144) uniprot|Q9P8P0 Kluyveromyces lactis MPK1 MAP kinase KLLA0B11924g 0 1043344 1047582 ON 2 B11924 complement(1043344..1047582) similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated Serine/threonine protein kinase involved in vacuolar protein sorting KLLA0B11946g 0 1048033 1049352 ON 2 B11946 complement(1048033..1049352) similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Mitogen-activated protein kinase required for spore morphogenesis that is expressed as a middle sporulation-specific gene KLLA0B11968g 0 1049643 1050335 ON 2 B11968 complement(1049643..1050335) similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W KLLA0B11990g 1 1050943 1052043 ON 2 B11990 (1050943..1052043) similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 KLLA0B12012g 0 1052188 1054341 ON 2 B12012 complement(1052188..1054341) similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W KLLA0B12034g 1 1054622 1054981 ON 2 B12034 (1054622..1054981) similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C MRS5 Essential protein of the inner mitochondrial membrane peripherally localized component of the TIM22 complex which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins KLLA0B12056g 1 1056188 1056469 ON 2 B12056 (1056188..1056469) highly similar to uniprot|P11632 Saccharomyces cerevisiae YPR052C NHP6A High-mobility group non-histone chromatin protein functionally redundant with Nhp6Bp homologous to mammalian high mobility group proteins 1 and 2 acts to recruit transcription factor Rcs1p to certain promoters KLLA0B12078g 1 1056994 1057770 ON 2 B12078 (1056994..1057770) highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA) functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair KLLA0B12100g 0 1057857 1058393 ON 2 B12100 complement(1057857..1058393) highly similar to uniprot|Q75B80 Ashbya gossypii ADL308C ADL308Cp and similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type required for replication of dsRNA virus KLLA0B12133g 1 1058858 1061998 ON 2 B12133 (1058858..1061998) similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm- to-vacuole targeting pathway also required for peroxisomal degradation (pexophagy) KLLA0B12155g 0 1062000 1063874 ON 2 B12155 complement(1062000..1063874) similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Protein with a potential role in DNA replication displays synthetic lethal genetic interaction with the pol3-13 allele of POL3 which encodes DNA polymerase delta KLLA0B12177g 0 1064233 1065621 ON 2 B12177 complement(1064233..1065621) similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W KLLA0B12199g 1 1065991 1066656 ON 2 B12199 (1065991..1066656) highly similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit KLLA0B12221g 0 1066808 1067875 ON 2 B12221 complement(1066808..1067875) highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon KLLA0B12243g 1 1068225 1071083 ON 2 B12243 (1068225..1071083) similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 clathrin Associated Protein complex Large subunit Large subunit of clathrin associated protein complex KLLA0B12265g 0 1071265 1072041 ON 2 B12265 complement(1071265..1072041) highly similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Single-domain racemase possibly non- specific due to the lack of the second domain which presumably determines specificity KLLA0B12287g 1 1072379 1074952 ON 2 B12287 (1072379..1074952) weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2 KLLA0B12309g 0 1075035 1076984 ON 2 B12309 complement(1075035..1076984) similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 Subunit of the DNA polymerase alpha-primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis KLLA0B12331g 0 1077179 1081255 ON 2 B12331 complement(1077179..1081255) weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p) required for interpolar microtubules to provide an outward force on the spindle poles KLLA0B12353g 1 1082023 1082277 ON 2 B12353 (1082023..1082277) similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A KLLA0B12375g 0 1082452 1083366 ON 2 B12375 complement(1082452..1083366) similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II catalyzes the first step of the riboflavin biosynthesis pathway KLLA0B12397g 0 1084129 1086468 ON 2 B12397 complement(1084129..1086468) similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C OCT1 Mitochondrial intermediate peptidase cleaves N-terminal residues of a subset of proteins upon import after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p) may contribute to mitochondrial iron homeostasis KLLA0B12419g 0 1086792 1088291 ON 2 B12419 complement(1086792..1088291) similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W FMP24 The authentic non-tagged protein was localized to the mitochondria KLLA0B12441g 1 1088719 1089669 ON 2 B12441 (1088719..1089669) weakly similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C KLLA0B12463g 0 1089742 1091010 ON 2 B12463 complement(1089742..1091010) similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W FOL3 Dihydrofolate synthetase involved in folic acid biosynthesis catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis Klac_YGOB_Anc_2.436 1 1091011 1091598 OFF 2 Anc_2.436 (1091011..1091598) ANNOTATED BY YGOB - Klac_YGOB_Anc_2.436b 1 1091248 1091598 ON 2 Anc_2.436b (1091248..1091598) ANNOTATED BY YGOB - KLLA0B12496g 1 1091875 1093158 ON 2 B12496 (1091875..1093158) weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C KLLA0B12518g 0 1093257 1093982 ON 2 B12518 complement(1093257..1093982) similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud KLLA0B12540g 1 1094239 1095804 ON 2 B12540 (1094239..1095804) similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C KLLA0B12562g 0 1095953 1099735 ON 2 B12562 complement(1095953..1099735) similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W MYO5 One of two type I myosins contains proline- rich tail homology 2 (TH2) and SH3 domains MYO5 deletion has little effect on growth but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization and to uniprot|P36006 Saccharomyces cerevisiae YKL129C MYO3 KLLA0B12584g 0 1100489 1102564 ON 2 B12584 complement(1100489..1102564) highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors localizes to the mitochondria expression of the gene is under general amino acid control KLLA0B12606g 0 1102700 1103167 ON 2 B12606 complement(1102700..1103167) no similarity KLLA0B12628g 0 1103388 1104254 ON 2 B12628 complement(1103388..1104254) similar to uniprot|P36069 Saccharomyces cerevisiae YKL128C PMU1 Phospho MUtase homolog. Small region homologous to active site of phospho-mutases these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1 bact. Pgm Hs Bpgm & rat fructose-2 6- bisphosphatase Phospo-mutase homolog KLLA0B12650g 0 1104366 1104749 ON 2 B12650 complement(1104366..1104749) similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources KLLA0B12672g 1 1105330 1107159 ON 2 B12672 (1105330..1107159) uniprot|Q6XCY9 Kluyveromyces lactis KU80 Ku80p KLLA0B12694g 1 1107696 1109402 ON 2 B12694 (1107696..1109402) highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C PGM2 Phosphoglucomutase catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate which is a key step in hexose metabolism functions as the acceptor for a Glc-phosphotransferase and to YKL127W uniprot|P33401 Saccharomyces cerevisiae YKL127W PGM1 Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6- phosphate, which is a key step in hexose metabolism KLLA0B12716g 1 1109939 1112089 ON 2 B12716 (1109939..1112089) similar to uniprot|P12688 Saccharomyces cerevisiae YKL126W YPK1 and similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C YPK2 serine/threonine protein kinase KLLA0B12738g 1 1112500 1114476 ON 2 B12738 (1112500..1114476) some similarities with uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Required for transcription of rDNA by RNA Polymerase I DNA-independent RNA Polymerase I transcription factor KLLA0B12760g 1 1114942 1116570 ON 2 B12760 (1114942..1116570) similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Suppressor of SHR3 confers leflunomide resistance when overexpressed (putative) involved in ER functions KLLA0B12782g 0 1116729 1117160 ON 2 B12782 complement(1116729..1117160) similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane KLLA0B12804g 1 1117475 1120033 ON 2 B12804 (1117475..1120033) similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C Protein of unknown function transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance KLLA0B12826g 1 1121106 1122065 ON 2 B12826 (1121106..1122065) similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter transports oxaloacetate sulfate and thiosulfate member of the mitochondrial carrier family KLLA0B12848g 1 1122397 1123482 ON 2 B12848 (1122397..1123482) similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in dolichol synthesis and weakly similar to YBR002C uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis- prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting KLLA0B12870g 0 1123581 1124198 ON 2 B12870 complement(1123581..1124198) weakly similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex KLLA0B12892g 1 1124666 1126543 ON 2 B12892 (1124666..1126543) similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W KLLA0B12914g 1 1126975 1128255 ON 2 B12914 (1126975..1128255) similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W KLLA0B12936g 0 1128687 1130792 ON 2 B12936 complement(1128687..1130792) similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W FAA1 Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids involved in the activation of imported fatty acids not required for growth on nonfermentable carbon sources essential for stationary phase and similar to YMR246W uniprot|P47912 Saccharomyces cerevisiae YMR246W FAA4 Long chain fatty acyl-CoA synthetase and similar to YIL009W uniprot|P39002 Saccharomyces cerevisiae YIL009W FAA3 Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery KLLA0B12958g 0 1131377 1132489 ON 2 B12958 complement(1131377..1132489) weakly similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1 removes RNA primers during Okazaki fragment synthesis degrades RNA attached to the 5'-end of a DNA strand KLLA0B12980g 0 1132843 1133715 ON 2 B12980 complement(1132843..1133715) conserved hypothetical protein KLLA0B13002g 0 1134173 1138306 ON 2 B13002 complement(1134173..1138306) weakly similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W KLLA0B13024g 0 1138572 1138946 ON 2 B13024 complement(1138572..1138946) similar to uniprot|Q05024 Saccharomyces cerevisiae YMR233W Interacts with Top1p in 2-hybrid assay KLLA0B13046g 0 1139556 1140170 ON 2 B13046 complement(1139556..1140170) similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis mouse homolog shows altered expression in Huntington's disease model mice KLLA0B13068g 0 1140423 1142438 ON 2 B13068 complement(1140423..1142438) some similarities with uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip required for the alignment of parental nuclei before nuclear fusion during mating KLLA0B13090g 0 1142698 1145763 ON 2 B13090 complement(1142698..1145763) similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins also interacts with Pep7p KLLA0B13112g 0 1146006 1148198 ON 2 B13112 complement(1146006..1148198) similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p and the high osmolarity response pathway via phosphorylation of Pbs2p regulated by Ste20p and Ste50p KLLA0B13123g 1 1148510 1148791 ON 2 B13123 (1148510..1148791) conserved hypothetical protein KLLA0B13134g 1 1149114 1150811 ON 2 B13134 (1149114..1150811) similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Protein involved in cell cycle regulation KLLA0B13145g 0 1150783 1151790 ON 2 B13145 complement(1150783..1151790) weakly similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 involved in vacuolar protein targeting KLLA0B13167g 1 1152802 1153566 ON 2 B13167 (1152802..1153566) similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway required for the transport of nitrogen- regulated amino acid permease Gap1p from the Golgi to the cell surface KLLA0B13189g 0 1153780 1155228 ON 2 B13189 complement(1153780..1155228) highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway KLLA0B13211g 0 1155757 1158504 ON 2 B13211 complement(1155757..1158504) similar to uniprot|Q06488 Saccharomyces cerevisiae YLR357W RSC2 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex required for expression of mid-late sporulation-specific genes contains two essential bromodomains a bromo-adjacent homology (BAH) domain and an AT hook KLLA0B13233g 0 1159097 1160833 ON 2 B13233 complement(1159097..1160833) highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease integral membrane protein with 13 putative membrane- spanning regions also involved in cysteine uptake KLLA0B13255g 0 1162142 1163938 ON 2 B13255 complement(1162142..1163938) highly similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase one of three factors required for mRNA 3'-end polyadenylation forms multiprotein complex with polyadenylation factor I (PF I) also required for mRNA nuclear export may also polyadenylate rRNAs KLLA0B13277g 1 1165743 1167797 ON 2 B13277 (1165743..1167797) highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 GTPase required for vacuolar protein sorting, functions in actin cytoskeleton organization via its interaction with Sla1p Klac_CEN2 1 1168861 1169058 ON 2 CEN2 (1168861..1169058) Chromosome II centromere KLLA0B13321g 1 1169757 1170353 ON 2 B13321 (1169757..1170353) highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase required for sulfate assimilation and involved in methionine metabolism KLLA0B13343g 0 1170477 1171404 ON 2 B13343 complement(1170477..1171127,1171345..1171404) similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies and for delivery of newly synthesized vacuolar enzymes to the vacuole involved in endocytosis KLLA0B13365g 1 1171833 1172222 ON 2 B13365 (1171833..1172222) similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit MRP17 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator KLLA0B13387g 0 1172683 1173948 ON 2 B13387 complement(1172683..1173948) similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase) required for sphingolipid synthesis can mutate to confer aureobasidin A resistance KLLA0B13409g 0 1174802 1175681 ON 2 B13409 complement(1174802..1175089,1175553..1175681) highly similar to uniprot|P36105 Saccharomyces cerevisiae YKL006W RPL14A and to uniprot|P38754 Saccharomyces cerevisiae YHL001W RPL14B Protein component of the large (60S) ribosomal subunit KLLA0B13431g 1 1177099 1177529 ON 2 B13431 (1177099..1177134,1177272..1177529) highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE required for transport of proteins between an early and a later Golgi compartment KLLA0B13453g 0 1177655 1178443 ON 2 B13453 complement(1177655..1178443) uniprot|O74232 Kluyveromyces lactis CAP1 CAPZA F- actin capping protein alpha subunit KLLA0B13475g 0 1178856 1180382 ON 2 B13475 complement(1178856..1180382) similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes KLLA0B13497g 1 1181036 1182262 ON 2 B13497 (1181036..1182262) similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p and similar to YHL003C uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)- coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p KLLA0B13519g 0 1182602 1183822 ON 2 B13519 complement(1182602..1183822) similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit KLLA0B13541g 1 1184200 1184715 ON 2 B13541 (1184200..1184715) similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in recombination KLLA0B13563g 0 1184809 1185525 ON 2 B13563 complement(1184809..1185525) highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly localizes to the nucleolus KLLA0B13585g 1 1186427 1190830 ON 2 B13585 (1186427..1190830) similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p two subunits of the 19S particle of the 26S proteasome cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins KLLA0B13607g 1 1191592 1194561 ON 2 B13607 (1191592..1194561) similar to uniprot|Q03497 Saccharomyces cerevisiae YHL007C STE20 Signal transducing kinase of the PAK (p21- activated kinase) family involved in pheromone response and pseudohyphal/invasive growth pathways activated by Cdc42p binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases KLLA0B13629g 0 1194646 1196397 ON 2 B13629 complement(1194646..1196397) similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C required for structural integrity of the spindle during anaphase spindle elongation interacts with histones H2A H2B and H4 phosphorylated by Ipl1p KLLA0B13651g 0 1196688 1198082 ON 2 B13651 complement(1196688..1198082) similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function has two CUE domains that bind ubiquitin which may facilitate intramolecular monoubiquitination KLLA0B13673g 0 1198278 1198961 ON 2 B13673 complement(1198278..1198961) conserved hypothetical protein KLLA0B13695g 0 1199239 1200366 ON 2 B13695 complement(1199239..1200366) some similarities with uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 bZIP transcription factor Klac_2.trna26V 0 1200998 1201071 ON 2 tV-AAC complement(1200998..1201071) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 KLLA0B13739g 0 1201317 1203608 ON 2 B13739 complement(1201317..1203608) similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion may have overlapping functions with Rad24p in the DNA damage replication checkpoint KLLA0B13761g 1 1204147 1205226 ON 2 B13761 (1204147..1205226) uniprot|P49379 Kluyveromyces lactis KLLA0B13761g CBF1 Centromere-binding protein 1 KLLA0B13794g 1 1206318 1209128 ON 2 B13794 (1206318..1209128) similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W KLLA0B13816g 0 1209339 1210580 ON 2 B13816 complement(1209339..1210580) similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase removes the amide group from N- terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation KLLA0B13838g 0 1211451 1213913 ON 2 B13838 complement(1211451..1213913) weakly similar to uniprot|P40355 Saccharomyces cerevisiae YJR061W KLLA0B13860g 1 1215461 1215943 ON 2 B13860 (1215461..1215943) highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2 contains two zinc binding domains and the N terminal domain is responsible for anchoring to the RNA pol I complex KLLA0B13882g 1 1216203 1217858 ON 2 B13882 (1216203..1217858) highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo KLLA0B13904g 0 1218228 1219598 ON 2 B13904 complement(1218228..1219598) highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity KLLA0B13926g 1 1220237 1221856 ON 2 B13926 (1220237..1221856) similar to uniprot|Q08975 Saccharomyces cerevisiae YPL258C THI21 Hydroxymethylpyrimidine phosphate kinase involved in the last steps in thiamine biosynthesis member of a gene family with THI20 and THI22 functionally redundant with Thi20p KLLA0B13948g 1 1222276 1229628 ON 2 B13948 (1222276..1229628) highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C TOR2 putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation distribution of the actin cytoskeleton and meiosis phosphatidylinositol kinase homolg KLLA0B13970g 0 1229757 1230185 ON 2 B13970 complement(1229757..1230185) similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Essential protein of unknown function KLLA0B13992g 1 1230397 1231455 ON 2 B13992 (1230397..1231455) similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon KLLA0B14014g 0 1231530 1233434 ON 2 B14014 complement(1231530..1233434) weakly similar to uniprot|P36041 Saccharomyces cerevisiae YKL204W EAP1 eIF4E-associated protein KLLA0B14036g 0 1234021 1237212 ON 2 B14036 complement(1234021..1237212) similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA KLLA0B14058g 0 1237669 1238253 ON 2 B14058 complement(1237669..1238253) similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Protein of unknown function that is involved in DNA repair mutant is sensitive to the base analog 6-N- hydroxylaminopurine while gene disruption does not increase the rate of spontaneous mutagenesis KLLA0B14080g 0 1238559 1239527 ON 2 B14080 complement(1238559..1239527) highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Protein that binds to the C- terminal domain of Hyp2p (eIF5A) has four to five HEAT- like repeats KLLA0B14102g 1 1240181 1240996 ON 2 B14102 (1240181..1240996) similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C KLLA0B14124g 0 1241070 1242383 ON 2 B14124 complement(1241070..1242383) highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Cytoplasmic protein required for cell viability identified by association with pre- ribosomal particles KLLA0B14146g 0 1242562 1243374 ON 2 B14146 complement(1242562..1243374) similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W KLLA0B14168g 0 1243715 1245538 ON 2 B14168 complement(1243715..1245538) conserved hypothetical protein KLLA0B14190g 0 1245746 1246495 ON 2 B14190 complement(1245746..1246495) no similarity Klac_2.trna27T 1 1246831 1246902 ON 2 tT-CGU (1246831..1246902) tRNA Type: Thr (T) | Anti-Codon: CGU | Cove Score: 77.41 KLLA0B14234g 0 1247175 1247831 ON 2 B14234 complement(1247175..1247831) similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene- fatty-acyl-phospholipid synthase) catalyzes the last two steps in phosphatidylcholine biosynthesis KLLA0B14256g 1 1248654 1252469 ON 2 B14256 (1248654..1252469) similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 ATP-binding cassette (ABC) transporter required for the export of a-factor catalyzes ATP hydrolysis coupled to a-factor transport contains 12 transmembrane domains and two ATP binding domains expressed only in MATa cells KLLA0B14278g 0 1252596 1255655 ON 2 B14278 complement(1252596..1255655) highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme involved in ubiquitin-mediated protein degradation and essential for viability KLLA0B14300g 1 1256190 1256783 ON 2 B14300 (1256190..1256783) similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p which is a Ran homolog of the Ras GTPase family and stimulates nucleotide release involved in nuclear protein import nucleotide release is inhibited by Yrb1p KLLA0B14322g 1 1256993 1258189 ON 2 B14322 (1256993..1258189) similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1- 371 allele KLLA0B14344g 0 1258807 1260069 ON 2 B14344 complement(1258807..1260069) similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM KLLA0B14366g 1 1260726 1262198 ON 2 B14366 (1260726..1262198) highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) KLLA0B14388g 0 1262423 1264300 ON 2 B14388 complement(1262423..1264300) similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Lipid phosphoinositide phosphatase of the ER and Golgi involved in protein trafficking and secretion KLLA0B14410g 1 1264616 1266736 ON 2 B14410 (1264616..1266736) similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin- mediated protein degradation forms complex with Cdc48p plays a role in controlling cellular ubiquitin concentration also promotes efficient NHEJ in postdiauxic/stationary phase KLLA0B14432g 1 1267069 1267877 ON 2 B14432 (1267069..1267110,1267269..1267877) weakly similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family when overexpressed can substitute for the function of Yra1p in export of poly(A) mRNA from the nucleus KLLA0B14454g 0 1268709 1269626 ON 2 B14454 complement(1268709..1269626) highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier imports inorganic phosphate into mitochondria functionally redundant with Pic2p but more abundant than Pic2 under normal conditions KLLA0B14476g 1 1271319 1272506 ON 2 B14476 (1271319..1272506) similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Flavohemoglobin may play a role in the oxidative stress response KLLA0B14498g 1 1275022 1277322 ON 2 B14498 (1275022..1277322) conserved hypothetical protein KLLA0B14531g 1 1278225 1278557 ON 2 B14531 (1278225..1278557) conserved hypothetical protein KLLA0B14553g 0 1278622 1279308 ON 2 B14553 complement(1278622..1279308) uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1 KLLA0B14575g 1 1280163 1280936 ON 2 B14575 (1280163..1280936) uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2 KLLA0B14597g 0 1281354 1281677 ON 2 B14597 complement(1281354..1281677) no similarity KLLA0B14619g 0 1284933 1286528 ON 2 B14619 complement(1284933..1286528) some similarities with uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide- bonded proteins KLLA0B14685g 0 1289025 1290740 ON 2 B14685 complement(1289025..1290740) weakly similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline-specific permease KLLA0B14707g 0 1291951 1292883 ON 2 B14707 complement(1291951..1292883) similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W YPR1 2-methylbutyraldehyde reductase may be involved in isoleucine catabolism KLLA0B14729g 0 1293568 1294983 ON 2 B14729 complement(1293568..1294983) weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine KLLA0B14751g 0 1296263 1298125 ON 2 B14751 complement(1296263..1298125) conserved hypothetical protein KLLA0B14773g 0 1298671 1299051 ON 2 B14773 complement(1298671..1299051) no similarity KLLA0B14795g 1 1299429 1301099 ON 2 B14795 (1299429..1301099) similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions KLLA0B14817g 1 1301705 1302100 ON 2 B14817 (1301705..1302100) weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro KLLA0B14839g 0 1304089 1305354 ON 2 B14839 complement(1304089..1305354) conserved hypothetical protein KLLA0B14861g 0 1305927 1307690 ON 2 B14861 complement(1305927..1307690) uniprot|P07921 Kluyveromyces lactis KLLA0B14861g LAC12 Lactose permease KLLA0B14883g 1 1310501 1313578 ON 2 B14883 (1310501..1313578) uniprot|P00723 Kluyveromyces lactis KLLA0B14883g LAC4 Beta-galactosidase KLLA0B14916g 1 1315518 1317170 ON 2 B14916 (1315518..1317170) some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p KLLA0B14927g 1 1317448 1318428 ON 2 B14927 (1317448..1318428) no similarity KLLA0B14949g 0 1319529 1320071 ON 2 B14949 complement(1319529..1320071) no similarity KLLA0C00110g 1 2600 3646 ON 3 C00110 (2600..3646) conserved hypothetical protein KLLA0C00132g 1 4440 5963 ON 3 C00132 (4440..5963) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0C00154g 0 6401 6868 ON 3 C00154 complement(6401..6868) conserved hypothetical protein KLLA0C00176g 1 7953 8393 ON 3 C00176 (7953..8393) no similarity KLLA0C00190g 1 10530 10829 ON 3 C00190 (10530..10829) conserved hypothetical protein KLLA0C00198g 1 12387 12674 ON 3 C00198 (12387..12674) no similarity KLLA0C00220g 1 13632 15506 ON 3 C00220 (13632..15506) similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C KLLA0C00242g 1 15961 16272 ON 3 C00242 (15961..16272) no similarity KLLA0C00264g 0 17326 18102 ON 3 C00264 complement(17326..18102) similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH KLLA0C00286g 1 19668 21206 ON 3 C00286 (19668..21206) conserved hypothetical protein KLLA0C00330g 1 23718 24050 ON 3 C00330 (23718..24050) conserved hypothetical protein KLLA0C00352g 0 24124 24909 ON 3 C00352 complement(24124..24909) uniprot|Q08398 Kluyveromyces lactis HMLAPLHA1 Mating- type protein ALPHA1 KLLA0C00374g 1 25132 25803 ON 3 C00374 (25132..25803) uniprot|Q9HDS5 Kluyveromyces lactis HMLALPHA2 Mating- type protein ALPHA2 KLLA0C00396g 0 26146 28839 ON 3 C00396 complement(26146..28839) uniprot|Q9HDS6 Kluyveromyces lactis HMLALPHA3 Mating- type protein ALPHA3 KLLA0C00440g 0 32008 33141 ON 3 C00440 complement(32008..33141) similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase KLLA0C00462g 1 33948 35330 ON 3 C00462 (33948..35330) weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 vacuole inheritance KLLA0C00484g 0 35397 38174 ON 3 C00484 complement(35397..38174) weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein found at replication forks required for DNA replication also required for Rad53p activation during DNA replication stress where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p protein involved in replication checkpoint KLLA0C00506g 0 38584 39576 ON 3 C00506 complement(38584..39576) highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit KLLA0C00528g 1 40060 40410 ON 3 C00528 (40060..40410) no similarity KLLA0C00550g 0 40901 41149 ON 3 C00550 complement(40901..41149) similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A KLLA0C00572g 1 42069 44207 ON 3 C00572 (42069..44207) similar to uniprot|P25375 Saccharomyces cerevisiae YCL057W PRD1 Zinc metalloendopeptidase found in the cytoplasm and intermembrane space of mitochondria KLLA0C00594g 0 44220 44804 ON 3 C00594 complement(44220..44804) conserved hypothetical protein KLLA0C00616g 1 45284 45739 ON 3 C00616 (45284..45739) no similarity KLLA0C00649g 1 46562 47566 ON 3 C00649 (46562..47566) conserved hypothetical protein KLLA0C00671g 0 47903 49039 ON 3 C00671 complement(47903..49039) no similarity KLLA0C00693g 1 49512 50483 ON 3 C00693 (49512..50483) similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KLLA0C00715g 0 50670 52187 ON 3 C00715 complement(50670..52187) conserved hypothetical protein KLLA0C00737g 1 53188 55689 ON 3 C00737 (53188..55689) similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation methylates G2922 in the putative tRNA docking site of the large subunit rRNA and in the absence of snR52 U2921 suppressor of PAB1 mutants KLLA0C00759g 0 55778 57022 ON 3 C00759 complement(55778..57022) similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I required for the autocatalytic post-translational processing of the protease B precursor Prb1p localizes to ER in lumenal orientation homolog of mammalian PIG-X KLLA0C00803g 1 59258 60580 ON 3 C00803 (59258..60580) some similarities with uniprot|P25579 Saccharomyces cerevisiae YCL051W LRE1 Protein involved in control of cell wall structure and stress response inhibits Cbk1p protein kinase activity overproduction confers resistance to cell-wall degrading enzymes KLLA0C00825g 0 61186 61569 ON 3 C00825 complement(61186..61569) highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C KLLA0C00847g 0 62156 63151 ON 3 C00847 complement(62156..63151) similar to uniprot|P22108 Saccharomyces cerevisiae YDR530c APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II KLLA0C00869g 1 64120 65241 ON 3 C00869 (64120..65241) similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W Pantothenate kinase (ATP:D-pantothenate 4'- phosphotransferase EC 2.7.1.33) catalyzes the first committed step in the universal biosynthetic pathway leading to CoA. KLLA0C00891g 0 65443 66498 ON 3 C00891 complement(65443..66498) weakly similar to uniprot|Q04431 Saccharomyces cerevisiae YDR532C KRE28 KLLA0C00913g 0 67336 68760 ON 3 C00913 complement(67336..68760) similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W KLLA0C00935g 0 69125 69352 ON 3 C00935 complement(69125..69352) similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A KLLA0C00957g 1 71640 71855 ON 3 C00957 (71640..71855) no similarity KLLA0C00979g 1 73295 74746 ON 3 C00979 (73295..74746) similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 dispensable for mitosis involved in middle/late stage of meiosis required for spore wall formation serine/threonine kinase homologous to Ste20p expressed in middle/late meiosis KLLA0C01001g 1 75286 76575 ON 3 C01001 (75286..76575) similar to uniprot|P25380 Saccharomyces cerevisiae YCL048W SPS22 Protein of unknown function redundant with Sps2p for the organization of the beta-glucan layer of the spore wall KLLA0C01023g 1 76863 78773 ON 3 C01023 (76863..78773) similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C Hypothetical ORF KLLA0C01045g 0 78938 79360 ON 3 C01045 complement(78938..79360) similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) binds to the drugs FK506 and rapamycin expression pattern suggests possible involvement in ER protein trafficking KLLA0C01067g 0 79651 81825 ON 3 C01067 complement(79651..81825) similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C KLLA0C01089g 0 82159 83307 ON 3 C01089 complement(82159..83307) similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C KLLA0C01111g 0 83710 85293 ON 3 C01111 complement(83710..85293) similar to uniprot|P17967 Saccharomyces cerevisiae YCL043C PDI and similar to uniprot|P32474 Saccharomyces cerevisiae YDR518W EUG1 Protein disulfide isomerases KLLA0C01133g 0 85863 87029 ON 3 C01133 complement(85863..87029) similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Golgi localized protein component of the spindle assembly checkpoint homolog of human GRASP65 which functions in postmitotic reassembly of Golgi stacks KLLA0C01155g 1 88084 89529 ON 3 C01155 (88084..89529) similar to uniprot|P17709 Saccharomyces cerevisiae YCL040W GLK1 Glucokinase catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism one of three glucose phosphorylating enzymes expression regulated by non-fermentable carbon sources KLLA0C01177g 1 89978 92131 ON 3 C01177 (89978..92131) similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W KLLA0C01188g 0 92124 93602 ON 3 C01188 complement(92124..93602) similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole KLLA0C01210g 0 93918 95408 ON 3 C01210 complement(93918..95408) weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes may function in the cytoplasm to modulate mRNA translation may be involved in organization of actin filaments RNA binding protein with La motif KLLA0C01232g 1 96317 97417 ON 3 C01232 (96317..97417) some similarities with uniprot|Q04408 Saccharomyces cerevisiae YDR514C Hypothetical ORF KLLA0C01254g 1 97735 98940 ON 3 C01254 (97735..98940) some similarities with uniprot|Q04408 Saccharomyces cerevisiae YDR514C Hypothetical ORF KLLA0C01276g 1 100213 101334 ON 3 C01276 (100213..101334) conserved hypothetical protein KLLA0C01298g 0 101676 101999 ON 3 C01298 complement(101676..101999) weakly similar to uniprot|P25567 Saccharomyces cerevisiae YCL037C SRO9 Associates with translating ribosomes and weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515W SLF1 RNA binding protein that associates with polysomes KLLA0C01320g 1 103218 104225 ON 3 C01320 (103218..104225) similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization KLLA0C01342g 0 104355 104954 ON 3 C01342 complement(104355..104954) similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C Hypothetical ORF KLLA0C01364g 1 105157 105417 ON 3 C01364 (105157..105417) some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C KLLA0C01386g 1 105812 106699 ON 3 C01386 (105812..106699) similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response invasive/filamentous growth and osmotolerance acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction KLLA0C01408g 0 106905 107885 ON 3 C01408 complement(106905..107885) similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 involved in rRNA processing KLLA0C01430g 0 108092 108481 ON 3 C01430 complement(108092..108481) some similarities with uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space required for acetate utilization and gluconeogenesis has orthologs in higher eukaryotes KLLA0C01452g 0 108796 111183 ON 3 C01452 complement(108796..111183) highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C KLLA0C01474g 0 111545 112765 ON 3 C01474 complement(111545..112765) similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein component of the interface between microtubules and kinetochore involved in sister chromatid separation essential in polyploid cells but not in haploid or diploid cells ortholog of mammalian CLIP-170 KLLA0C01496g 0 113533 114903 ON 3 C01496 complement(113533..114903) some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins KLLA0C01518g 1 116685 117131 ON 3 C01518 (116685..117131) no similarity KLLA0C01540g 1 118950 120482 ON 3 C01540 (118950..120482) uniprot|Q8NJT3 Kluyveromyces lactis Fus1 protein (Similarity). KLLA0C01562g 0 120691 121281 ON 3 C01562 complement(120691..121281) highly similar to uniprot|Q8NIM8 Saccharomyces cerevisiae YCL026C- B Hypothetical ORF and similar to YCL026c-A KLLA0C01584g 1 122103 123098 ON 3 C01584 (122103..123098) no similarity KLLA0C01606g 0 123485 125347 ON 3 C01606 complement(123485..125347) similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids KLLA0C01628g 1 126942 127223 ON 3 C01628 (126942..127223) highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W KLLA0C01650g 1 128119 131457 ON 3 C01650 (128119..131457) similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C KLLA0C01672g 0 131543 132772 ON 3 C01672 complement(131543..132772) weakly similar to uniprot|P41816 Saccharomyces cerevisiae YPL171C OYE3 Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) KLLA0C01694g 1 133089 134927 ON 3 C01694 (133089..134927) similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Hypothetical ORF KLLA0C01716g 1 135681 138188 ON 3 C01716 (135681..138188) weakly similar to Saccharomyces cerevisiae YLR177W Hypothetical ORF and to YDR505C uniprot|P50896 Saccharomyces cerevisiae YDR505C PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition KLLA0C01738g 0 138679 139272 ON 3 C01738 complement(138679..139272) similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Carboxypeptidase Y inhibitor (putative) lipid binding protein supressor of a cdc25 mutation KLLA0C01760g 1 139887 140798 ON 3 C01760 (139887..140798) similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase catalyzes Mg(2 )- independent dephosphorylation of phosphatidic acid (PA) lysophosphatidic acid and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA KLLA0C01782g 1 141519 142673 ON 3 C01782 (141519..142673) highly similar to uniprot|P10659 Saccharomyces cerevisiae YLR180W and to uniprot|P19358 Saccharomyces cerevisiae YDR502C SAM1 S-adenosylmethionine synthetase catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine one of two differentially regulated isozymes (Sam1p and Sam2p) KLLA0C01804g 0 143120 144034 ON 3 C01804 complement(143120..144034) similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Protein involved in endosomal protein sorting binds to Vps20 and Vps4 and may regulate Vps4function has coiled- coil domains mutants show class E vacuolar-protein sorting defects KLLA0C01826g 1 144307 146532 ON 3 C01826 (144307..146532) uniprot|P40418 Kluyveromyces lactis Regulatory protein SWI6 (Cell-cycle box factor, chain SWI6) (Trans- acting activator of HO endonuclease gene) (MBF subunit P90) KLLA0C01848g 0 146739 148310 ON 3 C01848 complement(146739..148310) similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W PLM2 Plasmid Maintenance and to uniprot|Q06266 YLR183C Saccharomyces cerevisiae TOS4 Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF KLLA0C01870g 1 148935 149708 ON 3 C01870 (148935..148941,149449..149708) highly similar to uniprot|P49166 Saccharomyces cerevisiae YLR185W RPL37A protein and to uniprot|P51402 Saccharomyces cerevisiae YDR500C RPL37B protein, components of the large (60S) ribosomal subunit KLLA0C01892g 0 149917 151911 ON 3 C01892 complement(149917..151911) weakly similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways interacts physically with Mec1p putative homolog of S. pombe Rad26 and human ATRIP KLLA0C01914g 1 152834 153592 ON 3 C01914 (152834..153592) highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Protein required for the maturation of the 18S rRNA and for 40S ribosome production associated with spindle/microtubules nuclear localization depends on physical interaction with Nop14p may bind snoRNAs KLLA0C01936g 1 153971 155902 ON 3 C01936 (153971..155902) similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating predicted to have 5 transmembrane segments and a coiled coil domain localizes to the shmoo tip regulated by Ste12p KLLA0C01969g 1 157410 160460 ON 3 C01969 (157410..160460) similar to Saccharomyces cerevisiae YLR187W SKG3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate and to YNL278W uniprot|P53836 Saccharomyces cerevisiae YNL278W CAF120 Part of the evolutionarily-conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation KLLA0C01991g 1 160778 162898 ON 3 C01991 (160778..162898) similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane mediates export of peptides generated upon proteolysis of mitochondrial proteins plays a role in the regulation of cellular resistance to oxidative stress KLLA0C02013g 1 163538 165001 ON 3 C02013 (163538..165001) similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway KLLA0C02035g 0 165312 168941 ON 3 C02035 complement(165312..168941) similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase conserved enzyme involved in synthesis of sterol glucoside membrane lipids involved in autophagy KLLA0C02057g 0 169406 170758 ON 3 C02057 complement(169406..170758) similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Inositol phosphosphingolipid phospholipase C hydrolyzes inositolphosphosphingolipids activated by phosphatidylserine cardiolipin and phosphatidylglycerol mediates Na and Li halotolerance contains a P loop-like domain KLLA0C02079g 1 171259 172042 ON 3 C02079 (171259..171463,171564..172042) conserved hypothetical protein KLLA0C02101g 1 172317 173351 ON 3 C02101 (172317..173351) similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Vacuolar membrane protein that seems to be involved in Mn2 homeostasis mutant is dependent on activation of the unfolded protein response pathway for viability KLLA0C02123g 1 173935 175614 ON 3 C02123 (173935..175614) similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W KLLA0C02145g 1 175962 176348 ON 3 C02145 (175962..176348) some similarities with uniprot|P25361 Saccharomyces cerevisiae YCR043C Hypothetical ORF KLLA0C02167g 0 176570 177619 ON 3 C02167 complement(176570..177619) similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C Putative hydroxyisocaproate dehydrogenase KLLA0C02189g 1 178544 182686 ON 3 C02189 (178544..182686) similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa) involved in RNA polymerase II transcription initiation KLLA0C02211g 1 182975 184675 ON 3 C02211 (182975..184675) similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W Hypothetical ORF KLLA0C02233g 0 184908 186374 ON 3 C02233 complement(184908..186374) conserved hypothetical protein KLLA0C02255g 1 189083 192571 ON 3 C02255 (189083..192571) similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Protein that interacts with topoisomerase I KLLA0C02277g 0 192607 194004 ON 3 C02277 complement(192607..194004) similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters KLLA0C02299g 0 194267 196243 ON 3 C02299 complement(194267..196243) similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p located on cytoplasmic vesicles essential for post-Golgi vesicle transport KLLA0C02321g 0 196533 202061 ON 3 C02321 complement(196533..202061) similar to uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNR1 KLLA0C02343g 0 203552 205297 ON 3 C02343 complement(203552..205297) similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C CAN1 Plasma membrane arginine permease requires phosphatidyl ethanolamine (PE) for localization exclusively associated with lipid rafts mutation confers canavanine resistance KLLA0C02365g 1 208462 210201 ON 3 C02365 (208462..210201) similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease one of three amino acid permeases (Alp1p Can1p Lyp1p) responsible for uptake of cationic amino acids KLLA0C02387g 1 211012 213882 ON 3 C02387 (211012..213882) similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase catalyzes first step in the biosynthesis of phosphatidylinositol-4 5- biphosphate may control cytokineses through the actin cytoskeleton KLLA0C02409g 1 214337 215518 ON 3 C02409 (214337..215518) similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W Essential protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p KLLA0C02431g 0 215644 216465 ON 3 C02431 complement(215644..216465) similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Putative translation initiation factor as suggested by computational analysis of large-scale protein- protein interaction data KLLA0C02453g 0 216740 219826 ON 3 C02453 complement(216740..219826) similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C KLLA0C02475g 1 220395 221432 ON 3 C02475 (220395..221432) highly similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation involved in transporting proteins from the ER to the cytosol KLLA0C02497g 0 221470 225054 ON 3 C02497 complement(221470..225054) similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Hypothetical ORF KLLA0C02519g 0 225470 226489 ON 3 C02519 complement(225470..226489) similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP) downregulates Plb1p-mediated turnover of phosphatidylcholine found in the cytosol and microsomes homologous to Pdr16p deletion affects phospholipid composition KLLA0C02541g 0 226721 227533 ON 3 C02541 complement(226721..227533) weakly similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C KLLA0C02563g 0 227814 228731 ON 3 C02563 complement(227814..228731) similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C KLLA0C02585g 1 229274 235831 ON 3 C02585 (229274..235831) similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase epsilon one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity also involved in DNA synthesis during DNA repair, KLLA0C02607g 1 236042 237463 ON 3 C02607 (236042..237463) similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing, KLLA0C02629g 1 237655 238632 ON 3 C02629 (237655..238632) some similarities with uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Nuclear protein that physically interacts with Irr1p a component of the cohesin complex may link together proteins involved in chromosome segregation mRNA splicing and DNA replication KLLA0C02651g 0 238695 239189 ON 3 C02651 complement(238695..239189) weakly similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Protein required for cell viability, KLLA0C02673g 0 239589 239813 ON 3 C02673 complement(239589..239813) highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake KLLA0C02695g 0 240212 242272 ON 3 C02695 complement(240212..242272) weakly similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Endoplasmic reticulum (ER)- localized peripheral membrane protein required for Golgi- to-ER retrograde traffic component of the ER target site that interacts with coatomer the major component of the COPI vesicle protein coat Klac_YGOB_snR71 0 242472 242550 ON 3 snR71 complement(242472..242550) ANNOTATED BY YGOB - location of BlastN HSP using Scer query KLLA0C02717g 0 242948 246508 ON 3 C02717 complement(242948..246508) similar to uniprot|P38717 Saccharomyces cerevisiae YNL257C SIP3 Protein that activates transcription through interaction with DNA-bound Snf1p C-terminal region has a putative leucine zipper motif potential Cdc28p substrate and to uniprot|P38851 Saccharomyces cerevisiae YHR155W YSP1 Hypothetical ORF KLLA0C02739g 0 246771 247952 ON 3 C02739 complement(246771..247952) similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triglyceride Lipase KLLA0C02761g 0 248365 249783 ON 3 C02761 complement(248365..249783) similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase involved in ubiquinone (Coenzyme Q) biosynthesis located on the matrix side of the mitochondrial inner membrane, KLLA0C02783g 1 250633 253029 ON 3 C02783 (250633..253029) similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway has dihydropteroate synthetase dihydro-6-hydroxymethylpterin pyrophosphokinase and dihydroneopterin aldolase activities KLLA0C02805g 0 253320 253790 ON 3 C02805 complement(253320..253790) highly similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C KLLA0C02827g 0 254087 255217 ON 3 C02827 complement(254087..255217) some similarities with uniprot|P53850 Saccharomyces cerevisiae YNL254C Hypothetical ORF KLLA0C02849g 1 255963 257285 ON 3 C02849 (255963..257285) some similarities with uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 transcription export complex component KLLA0C02871g 0 257493 258284 ON 3 C02871 complement(257493..258284) similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit KLLA0C02893g 0 258602 260473 ON 3 C02893 complement(258602..260473) similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein that interacts with the C- terminal domain of the RNA polymerase II large subunit (Rpo21p) required for transcription termination and 3' end maturation of nonpolyadenylated RNAs KLLA0C02915g 1 261280 265170 ON 3 C02915 (261280..265170) similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex with Mre11p and Xrs2p involved in processing double-strand DNA breaks in vegetative cells initiation of meiotic DSBs telomere maintenance and nonhomologous end joining KLLA0C02937g 0 265205 266755 ON 3 C02937 complement(265205..266755) similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Mitochondrial protein of unknown function and similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF KLLA0C02959g 0 266971 268209 ON 3 C02959 complement(266971..268209) similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49 KLLA0C02981g 1 268669 269157 ON 3 C02981 (268669..269157) similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein required along with Dph1p Dph2p Kti11p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) contains a DnaJ-like domain, KLLA0C03003g 0 269315 271279 ON 3 C03003 complement(269315..271279) similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Hypothetical ORF KLLA0C03025g 1 271793 274093 ON 3 C03025 (271793..274093) similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Protein required for cell viability KLLA0C03047g 1 274325 275247 ON 3 C03047 (274325..274347,274440..275247) similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75 KLLA0C03069g 0 275322 275942 ON 3 C03069 complement(275322..275942) weakly similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C KLLA0C03091g 0 276491 276817 ON 3 C03091 complement(276491..276817) highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 translation initiation factor eIF1 KLLA0C03113g 1 277789 279804 ON 3 C03113 (277789..279804) uniprot|Q707Z3 Kluyveromyces lactis KLLA0C03113g Sla2 protein KLLA0C03135g 0 279869 280555 ON 3 C03135 complement(279869..280555) highly similar to uniprot|Q9HG12 Kluyveromyces lactis KLLA0B14553g HMRA1 Mating-type protein A1 KLLA0C03157g 1 281410 282183 ON 3 C03157 (281410..282183) highly similar to uniprot|Q9HG13 Kluyveromyces lactis KLLA0B14575g HMRA2 Mating-type protein A2 KLLA0C03179g 0 282251 286687 ON 3 C03179 complement(282251..286687) weakly similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C Hypothetical ORF KLLA0C03201g 0 286973 288925 ON 3 C03201 complement(286973..288925) similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C and some similarities with YIL130W uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins Klac_YGOB_3960 1 291786 294220 ON 3 3960 (291786..293297,293300..294220) ANNOTATED BY YGOB - Artificial frameshift joining KLLA0C03223g and KLLA0C03234g Klac_YGOB_NCE101 0 294545 294814 ON 3 NCE101 complement(294545..294680,294783..294814) ANNOTATED BY YGOB - KLLA0C03256g 1 295057 295449 ON 3 C03256 (295057..295449) conserved hypothetical protein KLLA0C03278g 1 295796 296806 ON 3 C03278 (295796..296806) conserved hypothetical protein KLLA0C03300g 0 296848 299328 ON 3 C03300 complement(296848..299328) similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 ReCYcling 1 KLLA0C03322g 1 299405 300562 ON 3 C03322 (299405..300562) similar to uniprot|P32524 Saccharomyces cerevisiae YJL203W PRP21 Subunit of the SF3a splicing factor complex required for spliceosome assembly Klac_3.trna1K 1 301073 301162 ON 3 tK-UUU (301073..301109,301127..301162) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 67.82 KLLA0C03388g 1 301679 303421 ON 3 C03388 (301679..303421) similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function promoter contains a consensus binding sequence for factor Abf1p KLLA0C03410g 1 303739 307821 ON 3 C03410 (303739..307821) some similarities with uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns KLLA0C03432g 0 308036 310423 ON 3 C03432 complement(308036..310423) highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C Hypothetical ORF KLLA0C03454g 1 311611 314313 ON 3 C03454 (311611..314313) similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C PHO87 Low-affinity inorganic phosphate (Pi) transporter involved in activation of PHO pathway expression is independent of Pi concentration and Pho4p activity contains 12 membrane-spanning segments and to uniprot|P39535 Saccharomyces cerevisiae YJL198W PHO90 KLLA0C03476g 1 314815 318573 ON 3 C03476 (314815..318573) similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins KLLA0C03498g 0 318733 319734 ON 3 C03498 complement(318733..319734) similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase KLLA0C03520g 1 320298 321437 ON 3 C03520 (320298..321437) similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Ribosomal RNA Processing KLLA0C03542g 0 321724 322785 ON 3 C03542 complement(321724..322785) similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W FEN1 Fatty acid elongase involved in sphingolipid biosynthesis acts on fatty acids of up to 24 carbons in length mutations have regulatory effects on 1 3-beta- glucan synthase vacuolar ATPase and the secretory pathway, KLLA0C03564g 0 323354 327553 ON 3 C03564 complement(323354..327553) some similarities with uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1 KLLA0C03586g 1 328910 330481 ON 3 C03586 (328910..330481) similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association homologous to S. pombe Cdc18p KLLA0C03608g 1 330900 331577 ON 3 C03608 (330900..331577) similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 vacuolar protein sorting (putative) KLLA0C03630g 0 331750 332733 ON 3 C03630 complement(331750..332733) similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C KLLA0C03652g 1 333038 335155 ON 3 C03652 (333038..335155) some similarities with uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin required for vacuolar protein sorting KLLA0C03674g 0 335163 337289 ON 3 C03674 complement(335163..337289) similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP- dependent DNA helicase required for the maintenance of the mitochondrial genome not required for mitochondrial transcription, KLLA0C03696g 0 337551 339335 ON 3 C03696 complement(337551..339335) similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W KLLA0C03718g 0 339645 340607 ON 3 C03718 complement(339645..340607) highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon KLLA0C03740g 1 341104 342000 ON 3 C03740 (341104..342000) similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W KLLA0C03762g 1 342637 343557 ON 3 C03762 (342637..343557) similar to uniprot|Q12010 YOL092W Saccharomyces cerevisiae Hypothetical ORF KLLA0C03784g 1 344101 345969 ON 3 C03784 (344101..345969) weakly similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi KLLA0C03806g 1 346318 348768 ON 3 C03806 (346318..348768) weakly similar to uniprot|Q7LGP7 Saccharomyces cerevisiae YOL063C HUS1 KLLA0C03828g 1 349187 351568 ON 3 C03828 (349187..351568) similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function substrates include SPB proteins Spc42p Spc110p and Spc98p mitotic exit network protein Mob1p and checkpoint protein Mad1p KLLA0C03850g 0 351772 352947 ON 3 C03850 complement(351772..352947) highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex which is a highly conserved actin nucleation center required for the motility and integrity of actin patches involved in endocytosis and membrane growth and polarity KLLA0C03872g 0 353385 354515 ON 3 C03872 complement(353385..354515) some similarities with uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Hypothetical ORF KLLA0C03894g 0 354889 356316 ON 3 C03894 complement(354889..356316) similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Clathrin associated protein medium subunit, KLLA0C03916g 1 357026 358432 ON 3 C03916 (357026..358432) similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes KLLA0C03938g 0 358851 360632 ON 3 C03938 complement(358851..360632) some similarities with uniprot|Q12100 Saccharomyces cerevisiae YDL025C Protein of unknown function potentially phosphorylated by Cdc28p KLLA0C03960g 0 361124 363154 ON 3 C03960 complement(361124..363154) similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C , KLLA0C04004g 1 364969 366288 ON 3 C04004 (364969..366288) highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase key enzyme of glycerol synthesis essential for growth under osmotic stress expression regulated by high-osmolarity glycerol response pathway homolog of Gpd2p KLLA0C04037g 1 367627 368889 ON 3 C04037 (367627..368889) highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway potential Cdc28p substrate KLLA0C04059g 1 369331 371340 ON 3 C04059 (369331..371340) similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Hypothetical ORF KLLA0C04081g 1 371620 372480 ON 3 C04081 (371620..372480) similar to uniprot|Q12326 Saccharomyces cerevisiae YOL056W GPM3 and to YDL021W uniprot|Q12008 Saccharomyces cerevisiae YDL021W GPM2, Homologs of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis KLLA0C04103g 0 372753 374447 ON 3 C04103 complement(372753..374447) weakly similar to uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses KLLA0C04125g 1 375708 376982 ON 3 C04125 (375708..376982) weakly similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1 6-mannosyltransferase involved in cell wall mannan biosynthesis subunit of a Golgi-localized complex that also contains Anp1p Mnn9p Mnn11p and Mnn10p identified as a suppressor of a cell lysis sensitive pkc1-371 allele KLLA0C04147g 0 377185 380907 ON 3 C04147 complement(377185..380907) similar to uniprot|Q12451 Saccharomyces cerevisiae YDL019C OSH2 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability, KLLA0C04169g 0 381543 383621 ON 3 C04169 complement(381543..383621) similar to uniprot|P80235 YAR035W Saccharomyces cerevisiae YAT1 Outer carnitine acetyltransferase mitochondrial KLLA0C04191g 1 384198 386591 ON 3 C04191 (384198..386591) weakly similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase promotes mitotic exit by directly switching on the kinase activity of Dbf2p KLLA0C04213g 1 386815 387999 ON 3 C04213 (386815..387999) similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential protein kinase with unknown cellular role KLLA0C04235g 0 388102 389031 ON 3 C04235 complement(388102..389031) highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4- carboxamide ribotide (SAICAR) synthetase required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenin KLLA0C04257g 1 389812 391875 ON 3 C04257 (389812..391875) weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0C04279g 1 392168 394822 ON 3 C04279 (392168..394822) similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm binds rg-nuclear localization signals on Nab2p and Hrp1p plays a role in cell-cycle progression, KLLA0C04301g 1 395294 396892 ON 3 C04301 (395294..396892) similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression KLLA0C04323g 0 396979 397698 ON 3 C04323 complement(396979..397698) similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C KLLA0C04345g 1 397899 399326 ON 3 C04345 (397899..399326) similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p kinase activity correlates with cyclical DBF4 expression KLLA0C04367g 0 399631 400590 ON 3 C04367 complement(399631..400590) similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 ER protein involved in very long chain fatty acid synthesis KLLA0C04389g 1 401421 402428 ON 3 C04389 (401421..402428) similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W KLLA0C04411g 1 403257 405080 ON 3 C04411 (403257..405080) similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W HEX3 Ring finger protein involved in the DNA damage response with possible recombination role genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase) sporulation role interacts with Slx8p and Lin1p KLLA0C04433g 1 405523 406626 ON 3 C04433 (405523..406626) conserved hypothetical protein Klac_YGOB_Anc_3.187 0 406964 407473 ON 3 Anc_3.187 complement(406964..407278,407429..407473) ANNOTATED BY YGOB - KLLA0C04455g 1 408090 409448 ON 3 C04455 (408090..409448) weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function potentially phosphorylated by Cdc28p KLLA0C04477g 0 409543 413304 ON 3 C04477 complement(409543..413304) similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Hypothetical ORF KLLA0C04510g 1 413587 414180 ON 3 C04510 (413587..414180) similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex which promotes efficient protein folding KLLA0C04532g 0 414275 415111 ON 3 C04532 complement(414275..415111) weakly similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Hypothetical ORF KLLA0C04554g 1 415462 417156 ON 3 C04554 (415462..417156) similar to uniprot|Q756P6 Ashbya gossypii AER208C AER208Cp and weakly similar to YGR077C uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Required for peroxisome assembly peroxisome associated protein containing a PTS1 signal KLLA0C04576g 0 417217 419001 ON 3 C04576 complement(417217..419001) highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit KLLA0C04598g 0 419591 421885 ON 3 C04598 complement(419591..421885) highly similar to uniprot|Q06224 Saccharomyces cerevisiae YLR277C YSH1 subunit of Polyadenylation factor I (PF I) KLLA0C04620g 0 422705 426514 ON 3 C04620 complement(422705..426514) similar to uniprot|Q74ZB9 Ashbya gossypii AGR280C AGR280Cp and some similarites with YLR278C uniprot|Q05854 Saccharomyces cerevisiae YLR278C Protein of unknown function localizes to the nucleus potential Cdc28p substrate KLLA0C04642g 0 427221 427727 ON 3 C04642 complement(427221..427727) similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Hypothetical ORF KLLA0C04664g 1 427841 428791 ON 3 C04664 (427841..428791) similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Hypothetical ORF KLLA0C04686g 0 428962 429795 ON 3 C04686 complement(428962..429795) similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C ECI1 Peroxisomal delta3 delta2-enoyl-CoA isomerase hexameric protein that converts 3-hexenoyl-CoA to trans-2- hexenoyl- CoA essential for the beta-oxidation of unsaturated fatty acids oleate-induced KLLA0C04708g 1 430441 431253 ON 3 C04708 (430441..431253) similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase has a role in rDNA silencing and in lifespan determination KLLA0C04730g 0 431651 433306 ON 3 C04730 complement(431651..433306) similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase required for cell separation after mitosis transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p KLLA0C04752g 1 433528 433932 ON 3 C04752 (433528..433932) no similarity KLLA0C04774g 1 434720 436681 ON 3 C04774 (434720..436681) similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor activates the Arp2/3 protein complex that nucleates branched actin filaments localizes with the Arp2/3 complex to actin patches homolog of the human Wiskott-Aldrich syndrome protein (WASP) , KLLA0C04796g 0 436807 437865 ON 3 C04796 complement(436807..437865) some similarities with uniprot|Q05881 Saccharomyces cerevisiae YLR287C Hypothetical ORF KLLA0C04809g 0 438318 439038 ON 3 C04809 complement(438318..438506,439036..439038) similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C RPS30B and similar to uniprot|Q12087 Saccharomyces cerevisiae YLR287C-A RPS30A KLLA0C04818g 1 439585 440763 ON 3 C04818 (439585..440763) highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 phosphoserine transaminase KLLA0C04840g 0 440770 441930 ON 3 C04840 complement(440770..441930) similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 Involved in checkpoint control and DNA repair forms a clamp with Rad17p and Ddc1p that is loaded onto partial duplex DNA DNA damage checkpoint protein KLLA0C04862g 1 442167 444062 ON 3 C04862 (442167..444062) highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial GTPase of unknown function KLLA0C04884g 1 444289 444951 ON 3 C04884 (444289..444951) similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein required for respiratory growth and stability of the mitochondrial genome KLLA0C04906g 0 445437 447611 ON 3 C04906 complement(445437..447611) similar to uniprot|Q08908 Saccharomyces cerevisiae YOR384W KLLA0C04928g 1 449820 450344 ON 3 C04928 (449820..450344) some similarities with uniprot|Q08907 Saccharomyces cerevisiae YOR383C KLLA0C04950g 1 452463 452774 ON 3 C04950 (452463..452774) no similarity KLLA0C04994g 1 453438 455264 ON 3 C04994 (453438..455264) weakly similar to uniprot|Q04433 Saccharomyces cerevisiae YDR534c Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall KLLA0C05016g 0 456048 456527 ON 3 C05016 complement(456048..456527) conserved hypothetical protein KLLA0C05060g 1 458924 459601 ON 3 C05060 (458924..459601) weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W KLLA0C05082g 0 461375 462445 ON 3 C05082 complement(461375..462445) similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression KLLA0C05104g 0 462684 463316 ON 3 C05104 complement(462684..463316) similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER KLLA0C05126g 0 463657 464301 ON 3 C05126 complement(463657..464301) highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization RNA processing and transport interacts with Kap121p Kap123p and Pdr6p (karyophilin betas) Gsp1p homolog that is not required for viability KLLA0C05148g 0 464727 465506 ON 3 C05148 complement(464727..465506) conserved hypothetical protein KLLA0C05170g 0 465845 466174 ON 3 C05170 complement(465845..466174) similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis, KLLA0C05192g 0 466506 467075 ON 3 C05192 complement(466506..467075) weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 U1 snRNP protein required for pre- mRNA splicing KLLA0C05214g 1 467624 468916 ON 3 C05214 (467624..468916) highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities while these activities are found in separate proteins in S. pombe and humans KLLA0C05236g 1 469306 471111 ON 3 C05236 (469306..471111) similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase major glutathione-degrading enzyme expression induced mainly by nitrogen starvation, KLLA0C05258g 1 471500 475567 ON 3 C05258 (471500..475567) some similarities with uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1 3-beta-glucan synthesis and the Pkc1p- MAPK pathway potential Cdc28p substrate multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42 and of mutations in BEM4 Klac_3.trna2E 0 475717 475788 ON 3 tE-UUC complement(475717..475788) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0C05302g 1 476377 476808 ON 3 C05302 (476377..476808) no similarity KLLA0C05324g 1 478376 479665 ON 3 C05324 (478376..479665) uniprot|Q12628 Kluyveromyces lactis KLLA0C05324g Glucan 1 3-beta-glucosidase precursor KLLA0C05346g 1 480364 481104 ON 3 C05346 (480364..481104) weakly similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein interacting with Metacaspase (MCA1) KLLA0C05368g 1 481598 486415 ON 3 C05368 (481598..486415) some similarities with uniprot|Q08562 Saccharomyces cerevisiae YOR191W RIS1 Member of the SWI/SNF family of DNA-dependent ATPases plays a role in antagonizing silencing during mating-type switching contains an N- terminal domain that interacts with Sir4p and a C-terminal SNF2 domain KLLA0C05390g 1 486863 487588 ON 3 C05390 (486863..487588) similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W Hypothetical ORF KLLA0C05412g 1 487927 488601 ON 3 C05412 (487927..488601) conserved hypothetical protein Klac_3.trna3E 1 489024 489095 ON 3 tE-UUC (489024..489095) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0C05456g 0 489363 490034 ON 3 C05456 complement(489363..490034) no similarity KLLA0C05478g 1 490633 491040 ON 3 C05478 (490633..491040) highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C ERV14 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo required for the delivery of bud-site selection protein Axl2p to cell surface related to Drosophila cornichon KLLA0C05500g 0 491305 492183 ON 3 C05500 complement(491305..492183) some similarities with uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 associated with microtubules and essential regulator of microtubule stability KLLA0C05522g 1 494240 495862 ON 3 C05522 (494240..495862) some similarities with uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 negative growth regulatory protein KLLA0C05544g 1 496583 497374 ON 3 C05544 (496583..497374) similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase involved in the biosynthesis of siroheme also involved in the expression of PAPS reductase and sulfite reductase, KLLA0C05566g 0 497877 499310 ON 3 C05566 complement(497877..499310) similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria KLLA0C05588g 1 500622 502178 ON 3 C05588 (500622..502178) similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C SDS23 Spindle pole body protein and similar to YBR214W uniprot|P38314 Saccharomyces cerevisiae YBR214W SDS24 Nuclear protein with similarity to S. pombe Sds23, suppresses dis2 mutations KLLA0C05610g 1 502744 503295 ON 3 C05610 (502744..503295) some similarities with uniprot|P53171 Saccharomyces cerevisiae YGL057C KLLA0C05632g 0 503484 503978 ON 3 C05632 complement(503484..503978) highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2) involved in postreplication repair (with Rad18p) sporulation telomere silencing and ubiquitin-mediated N- end rule protein degradation (with Ubr1p) KLLA0C05654g 0 504568 505989 ON 3 C05654 complement(504568..505989) similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W Hypothetical ORF KLLA0C05676g 1 506539 508074 ON 3 C05676 (506539..508074) weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Highly charged basic protein required for normal cell-cycle regulation of histone gene transcription mutants display strong synthetic defects with subunits of FACT a complex that allows RNA Pol II to elongate through nucleosomes KLLA0C05698g 0 508204 510312 ON 3 C05698 complement(508204..510312) similar to uniprot|P38315 Saccharomyces cerevisiae YBR216C YBP1 and to uniprot|P53169 Saccharomyces cerevisiae YGL060W YBP2 KLLA0C05720g 1 510735 511304 ON 3 C05720 (510735..511304) similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Protein that becomes conjugated to Atg5p by the E1 enzyme Atg7p a step that is essential for autophagy KLLA0C05742g 1 511607 512233 ON 3 C05742 (511607..512233) similar to uniprot|Q75ED7 Ashbya gossypii AAR161W DUO1 DASH complex subunit DUO1 and weakly similar to YGL061C uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential mitotic spindle protein required to maintain spindle integrity and kinetochore function part of the multisubunit DASH complex which binds microtubules and is transferred to the kinetochore prior to mitosis KLLA0C05764g 0 512470 515991 ON 3 C05764 complement(512470..515991) highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W PYC1 and to YBR218C uniprot|P32327 Saccharomyces cerevisiae YBR218C PYC2 converts pyruvate to oxaloacetate pyruvate carboxylase KLLA0C05786g 0 517346 517720 ON 3 C05786 complement(517346..517720) similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Protein with sequence similarity to RNA polymerases; interacts with a DNA repair protein, Rad5p, in the two-hybrid system; may provide a link between recombination in direct repeats and transcription Klac_3.trna4P 0 517949 518069 ON 3 tP-UGG complement(517949..517984,518034..518069) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 58.81 KLLA0C05852g 1 518508 519956 ON 3 C05852 (518508..519956) weakly similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 rDNA transcription factor CF component which also contains Rrn6p and Rrn7p which is required for rDNA transcription by RNA polymerase I component of rDNA transcription factor KLLA0C05874g 0 520079 521740 ON 3 C05874 complement(520079..521740) weakly similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins genetically linked to the unfolded protein response (UPR) regulated through association with Hrd3p contains an H2 ring finger KLLA0C05896g 1 522074 522550 ON 3 C05896 (522074..522550) conserved hypothetical protein KLLA0C05918g 0 522995 523393 ON 3 C05918 complement(522995..523393) similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ exchanged for histone H2A in nucleosomes by the SWR1 complex involved in transcriptional regulation through prevention of the spread of silent heterochromatin KLLA0C05940g 1 524768 526690 ON 3 C05940 (524768..526690) uniprot|O59863 Kluyveromyces lactis KLLA0C05940g PLB Lysophospholipase precursor KLLA0C05962g 0 527216 528316 ON 3 C05962 complement(527216..528316) similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa) involved in RNA polymerase II transcription initiation potential Cdc28p substrate KLLA0C05984g 1 528906 530000 ON 3 C05984 (528906..530000) highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 RNA terminal phosphate cyclase- like protein involved in rRNA processing at sites A0 A1 and A2 does not possess detectable RNA cyclase activity , KLLA0C06006g 0 530169 531707 ON 3 C06006 complement(530169..531707) similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole overproduction of Mvp1p suppresses several dominant VPS1 mutations Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole KLLA0C06028g 0 532044 532961 ON 3 C06028 complement(532044..532961) similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Required for normal mitochondrial morphology and distribution Mdm12p is a mitochondrial outer membrane protein. An Mdm12p homolog exists in S. Pombe which confers a dominant negative phenotype when expressed in S. cerevisiae KLLA0C06050g 1 533200 533817 ON 3 C06050 (533200..533817) similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W Hypothetical ORF KLLA0C06072g 0 534152 534913 ON 3 C06072 complement(534152..534913) similar to uniprot|Q03673 Saccharomyces cerevisiae YMR003W KLLA0C06094g 0 535470 535919 ON 3 C06094 complement(535470..535919) similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W Hypothetical ORF KLLA0C06116g 0 536524 538881 ON 3 C06116 complement(536524..538881) similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 topoisomerase I KLLA0C06138g 1 540409 542535 ON 3 C06138 (540409..542535) similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C KLLA0C06160g 0 543239 543604 ON 3 C06160 complement(543239..543604) highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C KLLA0C06182g 1 544281 548840 ON 3 C06182 (544281..548840) similar to uniprot|Q75CF0 Ashbya gossypii ACL004W ACL004Wp and weakly similar to YOL004W uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 DNA binding protein involved in transcriptional regulation KLLA0C06204g 0 548912 550045 ON 3 C06204 complement(548912..550045) similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C DHHC- CRD protein KLLA0C06226g 1 550683 552461 ON 3 C06226 (550683..552461) similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Forms heterodimer with Yku80p known as Ku binds chromosome ends and is involved in maintaining normal telomere length and structure in addition to participating in the formation of silent chromatin at telomere-proximal genes KLLA0C06248g 0 552493 554043 ON 3 C06248 complement(552493..554043) similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C KLLA0C06270g 1 554658 554912 ON 3 C06270 (554658..554912) highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit KLLA0C06292g 0 555112 555882 ON 3 C06292 complement(555112..555882) some similarities with uniprot|Q03208 Saccharomyces cerevisiae YML119W KLLA0C06314g 0 556468 559419 ON 3 C06314 complement(556468..559419) similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C MSU1 RNase component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs KLLA0C06336g 1 561371 562930 ON 3 C06336 (561371..562930) highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons in contrast to the higher eukaryotic multisubunit respiratory complex I which is absent in S. cerevisiae KLLA0C06358g 0 563583 564482 ON 3 C06358 complement(563583..564482) highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle through its homolog and binding partner Gtr2p involved in phosphate transport and invasive growth human RagA and RagB proteins are functional homologs KLLA0C06380g 1 564762 565322 ON 3 C06380 (564762..565322) similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially- localized peptidyl-tRNA hydrolases dispensable for cell growth and for mitochondrial respiration Klac_3.trna5S 1 566067 566148 ON 3 tS-AGA (566067..566148) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 KLLA0C06446g 0 566371 567195 ON 3 C06446 complement(566371..567195) highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Partner of Nob1 Protein required for cell viability, KLLA0C06468g 1 567817 569568 ON 3 C06468 (567817..569568) similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial Distribution and Morphology KLLA0C06490g 0 569789 570358 ON 3 C06490 complement(569789..570358) similar to uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Required for final stages of splicesome maturation; promotes step 1 of splicing; spliceosome- associated protein KLLA0C06512g 1 570575 571810 ON 3 C06512 (570575..571810) similar to uniprot|Q04172 YDR393W Saccharomyces cerevisiae SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology KLLA0C06534g 1 572219 573505 ON 3 C06534 (572219..573505) highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates KLLA0C06567g 0 573595 575187 ON 3 C06567 complement(573595..575187) similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Protein involved in glycosyl phosphatidyl inositol synthesis most likely an alpha 1 2 mannosyltransferase utilized for addition of the fourth side-branching mannose onto the GPI core structure KLLA0C06589g 1 575605 578454 ON 3 C06589 (575605..578454) similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear protein; has similarity to Cse1p homologs including Nmd5p, Cse1p,Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; also has similarity to the karyopherin Kap95p KLLA0C06611g 0 578756 579217 ON 3 C06611 complement(578756..579217) similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Beta subunit of the NC2 dimeric histone-fold complex represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) KLLA0C06633g 1 580349 582244 ON 3 C06633 (580349..582244) similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0C06655g 1 582949 583596 ON 3 C06655 (582949..583596) highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase catalyzes the formation of both inosine monophosphate and guanosine monophosphate mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome KLLA0C06677g 0 583672 585093 ON 3 C06677 complement(583672..585093) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0C06699g 0 586603 587634 ON 3 C06699 complement(586603..587634) conserved hypothetical protein KLLA0C06721g 1 589402 590418 ON 3 C06721 (589402..590418) similar to uniprot|Q04179 YDR400W Saccharomyces cerevisiae URH1 uridine nucleosidase (uridine ribohydrolase) KLLA0C06743g 0 590585 592126 ON 3 C06743 complement(590585..592126) similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall homologous to cytochrome P-450s KLLA0C06765g 1 592993 594582 ON 3 C06765 (592993..594582) similar to uniprot|P21623 YDR403W Saccharomyces cerevisiae DIT1 Sporulation-specific enzyme required for spore wall maturation involved in the production of a soluble LL-dityrosine-containing precursor KLLA0C06787g 0 595180 595695 ON 3 C06787 complement(595180..595695) highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16 forms two subunit dissociable complex with Rpb4p KLLA0C06809g 1 596252 596680 ON 3 C06809 (596252..596309,596442..596680) similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit KLLA0C06842g 1 597029 598027 ON 3 C06842 (597029..598027) similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C Protein required for cell viability KLLA0C06864g 0 598412 598834 ON 3 C06864 complement(598412..598834) similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF KLLA0C06886g 0 599236 599709 ON 3 C06886 complement(599236..599709) similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W Hypothetical ORF KLLA0C06908g 0 599885 600571 ON 3 C06908 complement(599885..600571) similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Hypothetical ORF KLLA0C06930g 1 600876 602960 ON 3 C06930 (600876..602960) similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double- strand breaks and in telomere stability exhibits nuclease activity that appears to be required for RMX function widely conserved KLLA0C06952g 1 603325 604182 ON 3 C06952 (603325..604182) similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C KLLA0C06974g 0 604344 605684 ON 3 C06974 complement(604344..605684) similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex required for SAGA-mediated deubiquitination of histone H2B KLLA0C06996g 1 606430 607086 ON 3 C06996 (606430..607086) similar to uniprot|Q05015 Saccharomyces cerevisiae YMR222C FSH2 and similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C FSH3 Serine hydrolases KLLA0C07018g 1 607384 608169 ON 3 C07018 (607384..608169) similar to Saccharomyces cerevisiae and to YMR222C uniprot|Q05015 Saccharomyces cerevisiae FSH2 Serine hydrolase, KLLA0C07040g 1 608643 610190 ON 3 C07040 (608643..610190) similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C FMP42 The authentic non-tagged protein was localized to the mitochondria KLLA0C07062g 1 610600 611568 ON 3 C07062 (610600..611568) weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for repression of middle sporulation genes specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p KLLA0C07084g 0 611642 612979 ON 3 C07084 complement(611642..612979) similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate KLLA0C07106g 0 613222 617508 ON 3 C07106 complement(613222..617508) weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p KLLA0C07128g 1 617725 620925 ON 3 C07128 (617725..620925) similar to uniprot|Q756B5 Ashbya gossypii AER352C AER352Cp and weakly similar to YMR218C uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic KLLA0C07150g 0 620958 621740 ON 3 C07150 complement(620958..621740) similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III the fourth step in the heme biosynthetic pathway KLLA0C07172g 0 622165 623739 ON 3 C07172 complement(622165..623739) highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP) transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation KLLA0C07194g 1 624694 625587 ON 3 C07194 (624694..625587) conserved hypothetical protein KLLA0C07216g 1 626227 628278 ON 3 C07216 (626227..628278) similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C KLLA0C07238g 0 630279 631778 ON 3 C07238 complement(630279..631778) similar to uniprot|Q03655 Saccharomyces cerevisiae YMR215W GAS3 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall KLLA0C07260g 0 632987 634093 ON 3 C07260 complement(632987..634093) similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 dnaJ homolog KLLA0C07282g 0 634695 635138 ON 3 C07282 complement(634695..635138) similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control repressor of cap- dependent translation initiation competes with eIF4G for binding to eIF4E KLLA0C07304g 0 635351 636982 ON 3 C07304 complement(635351..636982) similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor associated with Prp19p and the spliceosome contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association evolutionarily conserved and homologous to S. pombe Cdc5p KLLA0C07326g 1 637629 639821 ON 3 C07326 (637629..639821) similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Non-essential protein of unknown function exhibits synthetic lethal genetic interactions with PHO85 green fluorescent protein (GFP)-fusion protein localizes to the cell periphery KLLA0C07348g 1 639956 641914 ON 3 C07348 (639956..641914) similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH member of the PalA/AIP1/Alix family interacts with the ESCRT-III subunits Snf7p suggesting a relationship between the response to pH and multivesicular body formation KLLA0C07359g 0 641901 643196 ON 3 C07359 complement(641901..643196) similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs gene is nuclear and encodes two isozymic forms KLLA0C07381g 0 643441 644847 ON 3 C07381 complement(643441..644847) similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W KLLA0C07403g 1 646269 647555 ON 3 C07403 (646269..647555) similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Hypothetical ORF KLLA0C07425g 0 647673 649007 ON 3 C07425 complement(647673..649007) highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 microtubule-associated protein, KLLA0C07447g 1 650118 651101 ON 3 C07447 (650118..651101) highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C Hypothetical ORF KLLA0C07469g 0 651446 652705 ON 3 C07469 complement(651446..652705) similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase acts in the biosynthesis of isoprenoids and sterols including ergosterol from mevalonate KLLA0C07491g 1 653352 655841 ON 3 C07491 (653352..655841) similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Vph1p and Stv1p) Vph1p is located in V- ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes KLLA0C07513g 0 656060 657379 ON 3 C07513 complement(656060..657379) similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration part of the dynein/dynactin pathway targets dynein to microtubule tips which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1 KLLA0C07535g 1 658746 660620 ON 3 C07535 (658746..660620) some similarities with uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H( )-ATPase Pma1p in response to glucose metabolism plays a role in ion homeostasis KLLA0C07557g 0 661000 662187 ON 3 C07557 complement(661000..662187) similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Involved in targeting of proteins to the mitochondrial inner membrane Pentamidine resistance protein involved in pentamidine resistance protein KLLA0C07579g 0 662466 664325 ON 3 C07579 complement(662466..664325) similar to uniprot|P40053 Saccharomyces cerevisiae YER080W FMP29 The authentic non-tagged protein was localized to the mitochondria KLLA0C07601g 0 665141 665833 ON 3 C07601 complement(665141..665833) weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Hypothetical ORF KLLA0C07623g 1 666694 668439 ON 3 C07623 (666694..668439) similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex required for homologous chromosome synapsis and chiasma formation KLLA0C07645g 1 668726 670249 ON 3 C07645 (668726..670249) similar to uniprot|P40051 Saccharomyces cerevisiae YER078C Hypothetical ORF KLLA0C07667g 0 670325 671494 ON 3 C07667 complement(670325..671494) some similarities with uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3 binds eIF3b subunit Prt1p has possible dual functions in transcriptional and translational control contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain KLLA0C07689g 1 671623 673776 ON 3 C07689 (671623..673776) weakly similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Hypothetical ORF KLLA0C07711g 0 674146 674925 ON 3 C07711 complement(674146..674925) similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation related to the human complement receptor gC1q-R KLLA0C07733g 1 676715 679666 ON 3 C07733 (676715..679666) similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the cytoplasm KLLA0C07744g 0 679857 680503 ON 3 C07744 complement(679857..679984,680200..680331,680413..680503) highly similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Integral membrane protein required for ER to Golgi transport KLLA0C07755g 0 680963 681943 ON 3 C07755 complement(680963..681367,681941..681943) highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C RPS24B and highly similar to uniprot|P26782 Saccharomyces cerevisiae YER074W RPS24A proteins component of the small (40S) ribosomal subunit KLLA0C07777g 0 682962 684506 ON 3 C07777 complement(682962..684506) highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase that is activated by K and utilizes NADP as the preferred coenzyme KLLA0C07799g 0 686756 687145 ON 3 C07799 complement(686756..687145) highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Protein involved in vacuolar maintenance KLLA0C07821g 1 687809 688165 ON 3 C07821 (687809..688165) weakly similar to uniprot|P40045 Saccharomyces cerevisiae YER071C KLLA0C07843g 0 688312 690696 ON 3 C07843 complement(688312..690696) similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis KLLA0C07865g 0 690987 692966 ON 3 C07865 complement(690987..692966) similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Hypothetical ORF KLLA0C07887g 0 693437 696064 ON 3 C07887 complement(693437..696064) highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits KLLA0C07909g 0 697288 697755 ON 3 C07909 complement(697288..697755) similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Mitochondrial outer membrane protein involved in membrane fission required for localization of Dnm1p and Mdv1p during mitochondrial division KLLA0C07931g 1 698086 698784 ON 3 C07931 (698086..698784) similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0C07953g 0 698867 699907 ON 3 C07953 complement(698867..699907) some similarities with uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Ran-GTPase-binding protein involved in nuclear export nuclear protein interacts with Gsp1p and Crm1p KLLA0C07975g 0 700213 700674 ON 3 C07975 complement(700213..700674) similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches KLLA0C07997g 0 701021 703591 ON 3 C07997 complement(701021..703591) highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5 6 Bifunctional enzyme with acetylglutamate kinase and N-acetyl-gamma-glutamyl- phosphate reductase activities catalyzes the second and third steps in the biosynthesis of the arginine precursor ornithine forms a complex with Arg2p KLLA0C08019g 0 704199 705104 ON 3 C08019 complement(704199..705104) weakly similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 U1snRNP 70K protein homolog, KLLA0C08041g 0 705516 707240 ON 3 C08041 complement(705516..707240) similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Component of the CCR4-NOT transcription regulatory complex which represses transcription at least in part by inhibiting functional TBP-DNA interactions and also aids in transcription elongation interacts with C- terminal region of Not1p KLLA0C08063g 0 707966 708457 ON 3 C08063 complement(707966..708457) highly similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C Hypothetical ORF Klac_3.trna6S 1 709414 709495 ON 3 tS-UGA (709414..709495) tRNA Type: Ser (S) | Anti-Codon: UGA | Cove Score: 84.16 KLLA0C08107g 1 710617 712245 ON 3 C08107 (710617..712245) highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase catalyzes the formation of succinate and glyoxylate from isocitrate a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose KLLA0C08151g 1 714910 716832 ON 3 C08151 (714910..716832) weakly similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W Hypothetical ORF and to uniprot|P40041 Saccharomyces cerevisiae YER064C Non-essential nuclear protein; null mutation has global effects on transcription KLLA0C08173g 0 717235 718728 ON 3 C08173 complement(717235..718728) some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Hypothetical ORF KLLA0C08195g 0 719857 720588 ON 3 C08195 complement(719857..720588) weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) (putative) involved in transcription KLLA0C08217g 1 721753 722523 ON 3 C08217 (721753..722523) highly similar to uniprot|P41277 Saccharomyces cerevisiae RHR2 and to YER062C uniprot|P40106 Saccharomyces cerevisiae HOR2, two redundant DL-glycerol-3- phosphatases, KLLA0C08239g 1 723077 724366 ON 3 C08239 (723077..724366) similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 homology with beta-keto-acyl synthases Protein homologous to beta-keto-acyl synthase KLLA0C08261g 0 724399 725100 ON 3 C08261 complement(724399..725100) similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Protein of unknown function involved in filamentous growth KLLA0C08283g 0 725563 727122 ON 3 C08283 complement(725563..727122) similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 and similar to uniprot|P40039 Saccharomyces cerevisiae YER060W FCY21 and similar to uniprot|Q12119 Saccharomyces cerevisiae YER060W-A FCY22, Purine-cytosine permeases KLLA0C08305g 0 728996 730225 ON 3 C08305 complement(728996..730225) similar to uniprot|P40186 Saccharomyces cerevisiae YIL050W PCL7 Pho85p cyclin of the Pho80p subfamily forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p involved in glycogen metabolism expression is cell-cycle regulated and weakly similar to YER059W uniprot|P40038 Saccharomyces cerevisiae YER059W PCL6 Pho85p cyclin of the Pho80p subfamily forms the major Glc8p kinase together with Pcl7p and Pho85p involved in the control of glycogen storage by Pho85p stabilized by Elongin C binding KLLA0C08327g 0 730884 731195 ON 3 C08327 complement(730884..731195) similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase KLLA0C08349g 1 731629 732051 ON 3 C08349 (731629..732051) similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro KLLA0C08371g 1 732878 733822 ON 3 C08371 (732878..732914,733482..733822) highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein KLLA0C08393g 1 734655 738101 ON 3 C08393 (734655..738101) highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Protein involved in the retrograde transport from the Golgi complex to the ER and the endosomal membrane traffic putative aminophospholipid translocase member of the highly conserved Drs2 family of P-type ATPases KLLA0C08415g 0 738306 739271 ON 3 C08415 complement(738306..739271) highly similar to uniprot|P50278 Saccharomyces cerevisiae YNR034W KLLA0C08437g 1 739541 739984 ON 3 C08437 (739541..739984) no similarity KLLA0C08448g 0 739952 742228 ON 3 C08448 complement(739952..742228) similar to uniprot|P37254 Saccharomyces cerevisiae YNR033W KLLA0C08470g 1 742530 742754 ON 3 C08470 (742530..742754) highly similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 Ubiquitin-like protein modifier KLLA0C08503g 0 742889 743923 ON 3 C08503 complement(742889..743923) similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase required for glycogen accumulation interacts with Tap42p which binds to and regulates other protein phosphatases, KLLA0C08525g 1 744554 749209 ON 3 C08525 (744554..749209) similar to uniprot|P53599 Saccharomyces cerevisiae YNR031C SSK2 Suppressor of Sensor Kinase (SLN1) A MAP kinase kinase kinase activator of Pbs2p KLLA0C08547g 1 749737 751284 ON 3 C08547 (749737..751284) highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C Protein required for cell viability, KLLA0C08569g 1 751571 752104 ON 3 C08569 (751571..752104) similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the small subunit KLLA0C08591g 0 752256 753881 ON 3 C08591 complement(752256..753881) similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ECM39 Alpha-1 6-mannosyltransferase localized to the ER responsible for the addition of the alpha-1 6 mannose to dolichol-linked Man7GlcNAc2 acts in the dolichol pathway for N-glycosylation KLLA0C08613g 1 754098 755366 ON 3 C08613 (754098..755366) similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF KLLA0C08635g 0 755556 756476 ON 3 C08635 complement(755556..756476) similar to gnl|GLV|DEHA0G11220g Debaryomyces hansenii DEHA0G11220g and weakly similar to YCR069W uniprot|P25334 Saccharomyces cerevisiae YCR069W CPR4 Peptidyl- prolyl cis-trans isomerase (cyclophilin) catalyzes the cis- trans isomerization of peptide bonds N- terminal to proline residues has a potential role in the secretory pathway, KLLA0C08657g 1 757100 759268 ON 3 C08657 (757100..759268) some similarities with YDR520c KLLA0C08679g 0 759288 760883 ON 3 C08679 complement(759288..760883) similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway, KLLA0C08701g 0 761257 762171 ON 3 C08701 complement(761257..762171) similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0C08723g 1 762625 765501 ON 3 C08723 (762625..765501) similar to uniprot|P11655 Saccharomyces cerevisiae YNR026C SEC12 Guanine nucleotide exchange factor (GEF) glycosylated integral membrane protein of the endoplasmic reticulum important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p KLLA0C08756g 0 765847 767130 ON 3 C08756 complement(765847..767130) similar to uniprot|Q75EN0 Ashbya gossypii AAR049C RAD18 Postreplication repair ubiquitin-protein ligase E3 RAD18 and weakly similar to YCR066W uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 Protein involved in postreplication repair binds single-stranded DNA and has single-stranded DNA dependent ATPase activity forms heterodimer with Rad6p contains RING-finger motif KLLA0C08778g 0 767642 769303 ON 3 C08778 complement(767642..769303) weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor involved in cell cycle specific transcription of SPC110 encoding a spindle pole body (SPB) calmodulin binding protein dosage-dependent suppressor of calmodulin mutants with specific defects in SPB assembly KLLA0C08800g 0 770303 770776 ON 3 C08800 complement(770303..770776) highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Klac_3.trna7S 0 771124 771217 ON 3 tS-CGA complement(771124..771168,771181..771217) tRNA Type: Ser (S) | Anti-Codon: CGA | Cove Score: 75.55 KLLA0C08866g 0 771719 773653 ON 3 C08866 complement(771719..773653) similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0C08888g 1 776287 781614 ON 3 C08888 (776287..781614) similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 or uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3, KLLA0C08910g 0 781726 782073 ON 3 C08910 complement(781726..782073) similar to uniprot|P25638 Saccharomyces cerevisiae YCR060W TAH1 HSP90 cofactor interacts with Hsp82p Pih1p Rvb1 and Rvb2 contains a single TPR domain with at least two TPR motifs KLLA0C08932g 1 782424 783239 ON 3 C08932 (782424..783239) similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 piecemeal microautophagy of the nucleus (PMN) KLLA0C08954g 0 783356 783883 ON 3 C08954 complement(783356..783883) similar to uniprot|Q75EM3 Ashbya gossypii AAR056C AAR056Cp and weakly similar to YNR024w KLLA0C08976g 1 784536 787271 ON 3 C08976 (784536..787271) highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) Eight WD-repeats with homology with G protein beta subunits flanked by nonhomologous N-terminal and C-terminal extensions regulatory protein KLLA0C08998g 1 787601 789214 ON 3 C08998 (787601..789214) weakly similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function KLLA0C09020g 0 789284 790816 ON 3 C09020 complement(789284..790816) highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 threonine synthase KLLA0C09042g 0 791144 792529 ON 3 C09042 complement(791144..792529) similar to uniprot|P53628 Saccharomyces cerevisiae YNR023W SNF12 73 kDa subunit of the SWI/SNF transcription activation complex homolog of Rsc6p subunit of the RSC chromatin remodeling complex KLLA0C09064g 1 793079 793483 ON 3 C09064 (793079..793483) similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit not essential for mitochondrial translation, KLLA0C09086g 0 793869 795095 ON 3 C09086 complement(793869..795095) similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Hypothetical ORF KLLA0C09108g 0 795433 796059 ON 3 C09108 complement(795433..796059) similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Hypothetical ORF KLLA0C09130g 1 796544 797287 ON 3 C09130 (796544..797287) similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C Hypothetical ORF KLLA0C09152g 0 797422 799209 ON 3 C09152 complement(797422..799209) similar to uniprot|P53629 Saccharomyces cerevisiae YNR019W ARE2 Acyl-CoA:sterol acyltransferase isozyme of Are1p endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen KLLA0C09174g 1 799820 800701 ON 3 C09174 (799820..800701) similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells coatomer forms the COP I vesicle coat whose functions are essential epsilon-COP coatomer subunit Sec28p KLLA0C09196g 1 801012 801962 ON 3 C09196 (801012..801962) similar to uniprot|P40056 Saccharomyces cerevisiae YER083C RMD7 Required for Meiotic nuclear Division functions in DNA replication and damage response Protein involved in cell wall function KLLA0C09218g 0 802178 802699 ON 3 C09218 complement(802178..802699) similar to uniprot|Q8PPU9 Xanthomonas axonopodis pv XAC0586 Hypothetical protein XAC0586 KLLA0C09240g 0 803446 804783 ON 3 C09240 complement(803446..804783) some similarities with uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid; dihydroorotate dehydrogenase KLLA0C09262g 1 805512 807188 ON 3 C09262 (805512..807188) highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C KLLA0C09284g 0 807377 810178 ON 3 C09284 complement(807377..810178) similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome substrate of the N-acetyltransferase Nat1p KLLA0C09306g 0 810584 811996 ON 3 C09306 complement(810584..811996) highly similar to uniprot|P40510 Saccharomyces cerevisiae YIL074C and to uniprot|P40054 Saccharomyces cerevisiae YER081W SER3 3-phosphoglycerate dehydrogenase, catalyze the first step in serine and glycine biosynthesis; isozyme of Ser33p KLLA0C09328g 0 812817 815795 ON 3 C09328 complement(812817..815638,815744..815795) similar to uniprot|P40511 Saccharomyces cerevisiae YIL073C SPO22 Klac_3.trna8A 1 816018 816090 ON 3 tA-AGC (816018..816090) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0C09372g 1 816494 817378 ON 3 C09372 (816494..817378) similar to uniprot|Q75FB1 Ashbya gossypii AAL180C AAL180Cp and weakly similar to YKR011C uniprot|Q02209 Saccharomyces cerevisiae YKR011C Hypothetical ORF KLLA0C09394g 1 817925 821479 ON 3 C09394 (817925..821479) weakly similar to uniprot|P47035 Saccharomyces cerevisiae YJL076W NET1 Core subunit of the RENT complex which is a complex involved in nucleolar silencing and telophase exit stimulates transcription by RNA polymerase I and regulates nucleolar structure KLLA0C09416g 0 821606 822820 ON 3 C09416 complement(821606..822820) similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1 Klac_3.trna9V 1 823593 823665 ON 3 tV-CAC (823593..823665) tRNA Type: Val (V) | Anti-Codon: CAC | Cove Score: 74.52 KLLA0C09460g 0 823980 824297 ON 3 C09460 complement(823980..824297) highly similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis required for protection from excess free beta-tubulin proposed to be involved the folding of beta- tubulin KLLA0C09482g 0 824667 825980 ON 3 C09482 complement(824667..825980) weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein may help establish daughter fate KLLA0C09504g 0 826607 827650 ON 3 C09504 complement(826607..827650) highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein required for cell viability KLLA0C09526g 1 828109 829110 ON 3 C09526 (828109..829110) highly similar to uniprot|Q6Q5I7 Saccharomyces cerevisiae YOR261C KLLA0C09548g 1 829526 830884 ON 3 C09548 (829526..830884) similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity human ortholog is associated with mitochondrial disorders KLLA0C09570g 0 831137 832621 ON 3 C09570 complement(831137..832621) similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression KLLA0C09592g 1 833061 834365 ON 3 C09592 (833061..834365) highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for spindle pole body duplication localized mainly to the nucleus throughout the cell cycle KLLA0C09625g 0 834462 835433 ON 3 C09625 complement(834462..835433) similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins similar to Aprataxin a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia KLLA0C09647g 0 835665 836555 ON 3 C09647 complement(835665..836555) similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit KLLA0C09669g 0 836857 837360 ON 3 C09669 complement(836857..837360) similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Component of the spindle pole body (SPB) half-bridge required for SPB duplication in mitosis and meiosis II homolog of mammalian centrin interacts with Kar1p KLLA0C09691g 1 837629 840094 ON 3 C09691 (837629..840094) weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex which is involved in partitioning the mitotic spindle between mother and daughter cells putative ortholog of mammalian p150(glued) KLLA0C09713g 0 840112 841452 ON 3 C09713 complement(840112..841452) similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis mutations cause defects in transcription and in biogenesis of cell wall proteins KLLA0C09735g 1 841867 844221 ON 3 C09735 (841867..844221) similar to uniprot|Q08693 Saccharomyces cerevisiae YOR256C Protein required for cell viability KLLA0C09757g 1 844760 845218 ON 3 C09757 (844760..845218) highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p damage response protein related to mammalian membrane progesterone receptors mutations lead to defects in telomeres mitochondria and sterol synthesis KLLA0C09779g 0 845329 845979 ON 3 C09779 complement(845329..845979) weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein of unknown function required for the construction of the outer spore wall layers KLLA0C09801g 0 846302 848068 ON 3 C09801 complement(846302..848068) similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export component of the nuclear pore ortholog of human TAP KLLA0C09823g 1 848641 850650 ON 3 C09823 (848641..850650) similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post- translational SRP-independent protein targeting and import into the ER KLLA0C09845g 0 850737 851228 ON 3 C09845 complement(850737..851228) similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat- shock resistance mating sporulation and telomeric silencing KLLA0C09867g 1 851501 852649 ON 3 C09867 (851501..852649) some similarities with uniprot|Q12467 Saccharomyces cerevisiae YPL168W KLLA0C09889g 0 852807 853379 ON 3 C09889 complement(852807..853379) similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W RBF17 Hypothetical ORF KLLA0C09911g 0 853608 857963 ON 3 C09911 complement(853608..857963) similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage KLLA0C09933g 1 858405 858869 ON 3 C09933 (858405..858869) weakly similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0C09944g 0 858858 859961 ON 3 C09944 complement(858858..859961) similar to uniprot|Q12529 Saccharomyces cerevisiae YPL165C SET6 KLLA0C09966g 1 860413 861312 ON 3 C09966 (860413..861312) similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C catalyzes transfer of the sulfane atom of thiosulfate to cyanide to form sulfite and thiocyanate, KLLA0C09988g 1 861625 862938 ON 3 C09988 (861625..862938) similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 cleavage/polyadenylation factor IA subunit interacts with Pcf11p in the 2-hybrid system cleavage/polyadenylation factor IA subunit KLLA0C10010g 1 863101 864906 ON 3 C10010 (863101..864906) weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition KLLA0C10032g 0 864922 867036 ON 3 C10032 complement(864922..867036) similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair forms a complex with Mlh1p to promote meiotic crossing-over mammalian homolog is implicated mammalian microsatellite instability KLLA0C10054g 0 867386 868093 ON 3 C10054 complement(867386..868093) no similarity KLLA0C10076g 0 869088 869918 ON 3 C10076 complement(869088..869918) similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Hypothetical ORF KLLA0C10098g 0 870147 871973 ON 3 C10098 complement(870147..871973) similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p, KLLA0C10120g 1 872435 873715 ON 3 C10120 (872435..873715) similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C Hypothetical ORF KLLA0C10142g 1 873948 874630 ON 3 C10142 (873948..874004,874115..874630) similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase KLLA0C10164g 0 874796 875173 ON 3 C10164 complement(874796..875173) similar to uniprot|Q75EY2 Ashbya gossypii AAL054W AAL054Wp and some similarites with YHR059W uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function required for survival upon exposure to K1 killer toxin KLLA0C10186g 1 875492 876298 ON 3 C10186 (875492..876298) similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 RNA polymerase II transcriptional regulation mediator RNA polymerase II mediator subunit KLLA0C10208g 1 876495 877100 ON 3 C10208 (876495..877100) similar to uniprot|P35176 Saccharomyces cerevisiae YDR304C CPR5 Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER KLLA0C10230g 1 877485 878324 ON 3 C10230 (877485..878324) conserved hypothetical protein KLLA0C10252g 0 878425 879078 ON 3 C10252 complement(878425..879078) similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate human PIG-Fp is a functional homolog ; GPI11 ER membrane protein KLLA0C10274g 0 879403 883305 ON 3 C10274 complement(879403..883305) similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 Functions in cleavage of 3'-ends of pre-mRNAs prior to polyadenylation 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160) Component of pre-mRNA cleavage factor II (CFII) 150-kDa protein associated with polyadenylation factor 1 (PF I) KLLA0C10296g 1 883644 884900 ON 3 C10296 (883644..884900) highly similar to uniprot|P32264 Saccharomyces cerevisiae YDR300C PRO1 Gamma-glutamyl kinase catalyzes the first step in proline biosynthesis and to YHR033W uniprot|P38690 Saccharomyces cerevisiae YHR033W Hypothetical ORF KLLA0C10318g 0 885031 886032 ON 3 C10318 complement(885031..886032) similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function may function in protein folding and/or rRNA processing interacts with a chaperone (Hsp82p) two chromatin remodeling factors (Rvb1p Rvb2p) and two rRNA processing factors (Rrp43p Nop58p), KLLA0C10340g 1 886390 888015 ON 3 C10340 (886390..888015) similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C KLLA0C10362g 0 888123 889703 ON 3 C10362 complement(888123..889703) similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein possibly involved in secretion multicopy suppressor of sensitivity to Brefeldin A KLLA0C10384g 1 890604 891224 ON 3 C10384 (890604..891224) uniprot|O74190 Kluyveromyces lactis KLLA0C10384g ATP5 ATP synthase subunit 5, mitochondrial precursor KLLA0C10406g 0 892040 893059 ON 3 C10406 complement(892040..893059) similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphingosine hydroxylase has a role in sphingolipid metabolism catalyses the conversion of sphinganine to phytosphingosine KLLA0C10439g 0 893936 894595 ON 3 C10439 complement(893936..894595) similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus binds to activation domains of acidic activators required for recombination-dependent mtDNA partitioning KLLA0C10461g 1 895022 897010 ON 3 C10461 (895022..897010) weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Hypothetical ORF KLLA0C10483g 1 897356 899260 ON 3 C10483 (897356..899260) similar to uniprot|Q06629 YDR295C Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p- Hda3p heterodimer; required for the activity of the complex; has similarity to Hda3p; Ploidy-related KLLA0C10505g 1 899784 901532 ON 3 C10505 (899784..901532) similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs) degrades phosphorylated long chain bases prefers C16 dihydrosphingosine-l-phosphate as a substrate KLLA0C10527g 1 901896 903242 ON 3 C10527 (901896..903242) similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W Protein required for cell viability KLLA0C10549g 1 903888 905618 ON 3 C10549 (903888..905618) highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 delta-1-pyrroline-5-carboxylate dehydrogenase KLLA0C10571g 1 906848 910381 ON 3 C10571 (906848..910381) similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Protein with a role in maintenance of cellular integrity interacts with components of the TOR pathway ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence KLLA0C10593g 1 911134 911859 ON 3 C10593 (911134..911859) similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Ribosomal Recycling Factor 1 originally characterized as FIL1 a Factor for Isocitrate Lyase expression mitochondrial ribosome recycling factor KLLA0C10615g 0 912077 913999 ON 3 C10615 complement(912077..913999) similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc7 mutants are defective in directing meiotic recombination events to homologous chromatids KLLA0C10670g 0 914466 914893 ON 3 C10670 complement(914466..914804,914891..914893) similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Vacuolar H+ ATPase subunit G of the catalytic (V1) sector KLLA0C10681g 1 915315 916583 ON 3 C10681 (915315..916583) similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA KLLA0C10692g 0 916718 918280 ON 3 C10692 complement(916718..918280) weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Fatty acid desaturase required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria KLLA0C10714g 1 919128 920930 ON 3 C10714 (919128..920930) similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor - alpha subunit contain GTPase domains involved in SRP- dependent protein targeting interacts with SRP102p , KLLA0C10736g 0 921019 924258 ON 3 C10736 complement(921019..924258) similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W Hypothetical ORF KLLA0C10758g 1 924736 925824 ON 3 C10758 (924736..925824) similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Regulator of Ty1 Transposition regulator of Ty1 Transposition KLLA0C10780g 0 925855 926574 ON 3 C10780 complement(925855..926476,926561..926574) similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 RNA polymerase II holoenzyme/mediator subunit KLLA0C10802g 0 926916 931934 ON 3 C10802 complement(926916..931934) similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase phosphorylates the alpha- subunit of translation initiation factor eIF2 (Sui2p) in response to starvation activated by uncharged tRNAs and the Gcn1p-Gcn20p complex KLLA0C10835g 0 932418 933311 ON 3 C10835 complement(932418..933311) similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase zinc- regulated vacuolar membrane-associated lipid phosphatase dephosphorylates DGPP to phosphatidate (PA) and Pi then PA to diacylglycerol involved in lipid signaling and cell metabolism KLLA0C10857g 1 934234 935595 ON 3 C10857 (934234..935595) similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W KLLA0C10879g 1 936212 938479 ON 3 C10879 (936212..938479) weakly similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Synaptonemal complex (SC) protein that connects homologous chromosomes partially during zygotene and entirely during pachytene potential Cdc28p substrate synaptonemal complex protein KLLA0C10901g 0 938502 938837 ON 3 C10901 complement(938502..938837) similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Hypothetical ORF KLLA0C10923g 0 939148 941475 ON 3 C10923 complement(939148..941475) weakly similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p KLLA0C10945g 1 941764 942981 ON 3 C10945 (941764..942981) similar to YLR015W, uniprot|P43132 Saccharomyces cerevisiae YLR015W (BRE2) KLLA0C10967g 1 943312 944514 ON 3 C10967 (943312..944514) similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting NeXin KLLA0C10989g 0 944739 945455 ON 3 C10989 complement(944739..945455) similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 tRNA-specific adenosine-34 deaminase subunit Tad2p KLLA0C11011g 0 945689 946417 ON 3 C11011 complement(945689..946417) highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W KLLA0C11033g 1 947926 950505 ON 3 C11033 (947926..950505) highly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase KLLA0C11055g 0 950647 952293 ON 3 C11055 complement(950647..952293) similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Hypothetical ORF KLLA0C11077g 1 952702 953715 ON 3 C11077 (952702..953715) weakly similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit required for RNase H2 activity KLLA0C11099g 1 954057 954974 ON 3 C11099 (954057..954974) highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'- >5' exonucleases KLLA0C11121g 0 955199 955576 ON 3 C11121 complement(955199..955576) no similarity KLLA0C11143g 1 956474 957280 ON 3 C11143 (956474..957280) similar to uniprot|P38773 Saccharomyces cerevisiae and to YHR044C uniprot|P38774 Saccharomyces cerevisiae DOG1 2- deoxyglucose-6-phosphate phosphatase KLLA0C11165g 0 957421 958491 ON 3 C11165 complement(957421..958491) similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Hypothetical ORF KLLA0C11187g 1 959457 962360 ON 3 C11187 (959457..962360) similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function expression is regulated by phosphate levels green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole, KLLA0C11209g 1 962988 964871 ON 3 C11209 (962988..964871) conserved hypothetical protein KLLA0C11231g 1 965524 966840 ON 3 C11231 (965524..966840) highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Translation release factor involved in translation termination mutant form acts as a recessive omnipotent suppressor KLLA0C11253g 0 967067 969457 ON 3 C11253 complement(967067..969457) similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus involved in biogenesis of large (60S) ribosomal subunits KLLA0C11275g 1 969789 970853 ON 3 C11275 (969789..970853) similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Hypothetical ORF KLLA0C11297g 1 971068 971481 ON 3 C11297 (971068..971481) similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2 KLLA0C11319g 0 971620 974391 ON 3 C11319 complement(971620..974391) similar to uniprot|P14242 Saccharomyces cerevisiae, YNL082W KLLA0C11341g 1 974626 975321 ON 3 C11341 (974626..975321) similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Subunit of DNA polymerase zeta which is involved in DNA repair required for mutagenesis induced by DNA damage KLLA0C11363g 0 975442 976995 ON 3 C11363 complement(975442..976995) similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 Probable transporter member of the Ca2 - binding subfamily of the mitochondrial carrier family with two EF-hand motifs Pet9p and Sal1p have an overlapping function critical for viability polymorphic in different S. cerevisiae strains KLLA0C11385g 1 978786 980387 ON 3 C11385 (978786..980387) conserved hypothetical protein KLLA0C11407g 0 980649 983006 ON 3 C11407 complement(980649..983006) some similarities with uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells localizes to the incipient bud site and bud neck glycosylated by Pmt4p potential Cdc28p substrate KLLA0C11429g 1 984117 985259 ON 3 C11429 (984117..985259) similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis actin cytoskeletal organization and cell wall morphogenesis forms a complex with Sla1p and Pan1p KLLA0C11451g 0 985410 986999 ON 3 C11451 complement(985410..986999) highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo KLLA0C11473g 0 987546 989264 ON 3 C11473 complement(987546..989264) similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8 KLLA0C11495g 0 990832 992169 ON 3 C11495 complement(990832..992169) some similarities with uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences required for pre-rRNA processing and ribosome biogenesis KLLA0C11517g 0 993074 994636 ON 3 C11517 complement(993074..994636) no similarity KLLA0C11539g 0 995618 996529 ON 3 C11539 complement(995618..996529) some similarities with YGR161c, uniprot|Q7ZA12 Saccharomyces cerevisiae Hypothetical ORF, RTS3 SGDID:S0003393 KLLA0C11561g 0 997866 998933 ON 3 C11561 complement(997866..998933) no similarity KLLA0C11583g 0 999466 1001553 ON 3 C11583 complement(999466..1001553) similar to uniprot|Q752T1 Ashbya gossypii AFR492W AFR492Wp and weakly similar to YGL021W uniprot|P43633 Saccharomyces cerevisiae YGL021W ALK1 leucine zipper (putative) membrane protein (putative) and YBL009W uniprot|P32789 Saccharomyces cerevisiae YBL009W haspin KLLA0C11605g 1 1002022 1002807 ON 3 C11605 (1002022..1002807) weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C KLLA0C11627g 0 1002978 1005254 ON 3 C11627 complement(1002978..1005254) similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen KLLA0C11649g 0 1005591 1006307 ON 3 C11649 complement(1005591..1006307) similar to uniprot|P32656 Saccharomyces cerevisiae YER163C Hypothetical ORF KLLA0C11671g 0 1006574 1007575 ON 3 C11671 complement(1006574..1007575) highly similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Hypothetical ORF KLLA0C11693g 1 1008096 1008494 ON 3 C11693 (1008096..1008494) similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase located in the mitochondrial inner membrane KLLA0C11715g 1 1008738 1010867 ON 3 C11715 (1008738..1010867) similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments KLLA0C11737g 0 1010903 1011121 ON 3 C11737 complement(1010903..1011121) highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH involved in transcription initiation homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair KLLA0C11759g 1 1011298 1013889 ON 3 C11759 (1011298..1013889) similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 vacuolar protein sorting component of vacuolar membrane protein complex KLLA0C11781g 0 1014012 1016309 ON 3 C11781 complement(1014012..1016309) uniprot|Q01072 Kluyveromyces lactis KLLA0C11781g RAG3 RAG3 protein KLLA0C11803g 0 1016775 1017212 ON 3 C11803 complement(1016775..1017212) conserved hypothetical protein KLLA0C11825g 1 1017514 1018821 ON 3 C11825 (1017514..1018821) weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Protein involved in telomere length regulation functions in telomere metabolism during late S phase KLLA0C11847g 1 1019168 1020301 ON 3 C11847 (1019168..1020301) similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8 KLLA0C11869g 0 1020415 1021002 ON 3 C11869 complement(1020415..1021002) similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to vesicles along with the v-SNARE Tlg2p green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0C11891g 0 1021360 1023213 ON 3 C11891 complement(1021360..1023213) some similarities with uniprot|P40095 Saccharomyces cerevisiae YER158C KLLA0C11913g 0 1024233 1025822 ON 3 C11913 complement(1024233..1025822) similar to gnl|GLV|DEHA0E23727g Debaryomyces hansenii DEHA0E23727g and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway KLLA0C11935g 0 1026490 1026942 ON 3 C11935 complement(1026490..1026942) some similarities with uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex homologous to human NC2alpha KLLA0C11957g 0 1027449 1027661 ON 3 C11957 complement(1027449..1027661) similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) involved in transfer of secretory precursors through the endoplasmic reticulum membrane endoplasmic reticulum protein that is part of the Sec61 trimeric complex and the Ssh1 trimeric complex KLLA0C11979g 0 1027919 1028704 ON 3 C11979 complement(1027919..1028704) similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 involved in processing rRNA precursor species to mature rRNAs involved in rRNA processing KLLA0C12001g 0 1029092 1029871 ON 3 C12001 complement(1029092..1029871) similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases KLLA0C12023g 1 1030677 1031300 ON 3 C12023 (1030677..1031300) similar to uniprot|Q754A8 Ashbya gossypii AFR164W AFR164Wp and some similarites with YGL105W uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids KLLA0C12034g 0 1031339 1031578 ON 3 C12034 complement(1031339..1031578) conserved hypothetical protein Klac_3.trna10W 0 1031485 1031592 ON 3 tW-CCA complement(1031485..1031520,1031557..1031592) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 66.27 Klac_3.trna11R 1 1032177 1032248 ON 3 tR-UCU (1032177..1032248) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 KLLA0C12111g 1 1032731 1033771 ON 3 C12111 (1032731..1033771) similar to uniprot|Q12239 Saccharomyces cerevisiae YOL107W Hypothetical ORF KLLA0C12133g 0 1033945 1034874 ON 3 C12133 complement(1033945..1034874) similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Klac_3.trna12T 1 1035240 1035312 ON 3 tT-AGU (1035240..1035312) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 KLLA0C12177g 0 1035757 1037028 ON 3 C12177 complement(1035757..1037028) some similarities with uniprot|Q12215 Saccharomyces cerevisiae YOL105C WSC3 cell wall integrity and stress response component 3 Putative integral membrane protein containing novel cysteine motif KLLA0C12199g 1 1037929 1038525 ON 3 C12199 (1037929..1038525) similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0C12221g 1 1038876 1039304 ON 3 C12221 (1038876..1039304) similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation GFP-fusion protein localizes to the cytoplasm and nucleus KLLA0C12243g 1 1039717 1041024 ON 3 C12243 (1039717..1041024) weakly similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by inactivating it co-operates with Ypk1p in mediating resistance to myriocin converts myriocin into N-acetyl-myriocin KLLA0C12265g 0 1041161 1042486 ON 3 C12265 complement(1041161..1042486) similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase acts in ergosterol biosynthesis mutants accumulate the abnormal sterol ignosterol (ergosta-8 14 dienol) and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions KLLA0C12287g 0 1042861 1043847 ON 3 C12287 complement(1042861..1043847) weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes KLLA0C12300g 1 1044346 1045434 ON 3 C12300 (1044346..1045434) weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER required for N- and O-glycosylation in the Golgi but not in the ER forms a complex with the cytosolic Tip20p, KLLA0C12309g 1 1046848 1048557 ON 3 C12309 (1046848..1048557) highly similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively KLLA0C12331g 1 1049113 1051101 ON 3 C12331 (1049113..1051101) similar to uniprot|Q04373 YDR496C Saccharomyces cerevisiae PUF6 Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences KLLA0C12353g 1 1051312 1053930 ON 3 C12353 (1051312..1053930) weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Vacuolar sorting protein KLLA0C12375g 0 1054019 1055032 ON 3 C12375 complement(1054019..1055032) weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit genetic interactions suggest a possible role in promoting translation initiation KLLA0C12397g 0 1055443 1056153 ON 3 C12397 complement(1055443..1056153) similar to uniprot|Q12272 YOL102C Saccharomyces cerevisiae TPT1 tRNA 2'-phosphotransferase KLLA0C12419g 0 1056703 1057050 ON 3 C12419 complement(1056703..1057050) similar to uniprot|Q03429 YDR493W Saccharomyces cerevisiae YDR493W FMP36 KLLA0C12441g 0 1057427 1058374 ON 3 C12441 complement(1057427..1058374) similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W IZH1 Membrane protein involved in zinc metabolism member of the four-protein IZH family transcription is regulated directly by Zap1p expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc KLLA0C12463g 0 1058741 1059361 ON 3 C12463 complement(1058741..1059361) no similarity KLLA0C12485g 1 1060167 1062944 ON 3 C12485 (1060167..1062944) similar to uniprot|Q12236 YOL100W Saccharomyces cerevisiae YOL100W PKH2 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis KLLA0C12507g 0 1063093 1064570 ON 3 C12507 complement(1063093..1064427,1064541..1064570) similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Actin-related protein involved in transcriptional regulation; subunit of the chromatin remodeling Snf/Swi complex KLLA0C12529g 1 1064844 1065398 ON 3 C12529 (1064844..1065398) highly similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histones required for proper kinetochore function homolog of human CENP-A KLLA0C12551g 0 1065593 1067416 ON 3 C12551 complement(1065593..1067416) weakly similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized SH3 domain- containing protein required for cytokinesis KLLA0C12573g 1 1068765 1071257 ON 3 C12573 (1068765..1071257) similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0C12595g 0 1071642 1072568 ON 3 C12595 complement(1071642..1072568) similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W KLLA0C12617g 1 1073463 1074119 ON 3 C12617 (1073463..1074119) some similarities with uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Component of the DASH complex that binds to microtubules and kinetochores and is essential for chromosome segregation phosphorylated during the cell cycle by cyclin-dependent kinases KLLA0C12639g 1 1074370 1074624 ON 3 C12639 (1074370..1074624) highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial Distribution and Morphology KLLA0C12672g 1 1075548 1077485 ON 3 C12672 (1075548..1077485) some similarities with uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor forms a complex with Rad26p in chromatin enables ubiquitination and proteolysis of RNAPII KLLA0C12694g 1 1077786 1078565 ON 3 C12694 (1077786..1078565) similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier- protein] reductase may comprise a type II mitochondrial fatty acid synthase along with Mct1p KLLA0C12716g 1 1079048 1079551 ON 3 C12716 (1079048..1079551) highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C RBF18 Hypothetical ORF KLLA0C12749g 1 1079939 1081603 ON 3 C12749 (1079939..1081603) similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far9p Far10p and Far11p KLLA0C12771g 1 1081988 1085017 ON 3 C12771 (1081988..1085017) similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p KLLA0C12793g 0 1085044 1086129 ON 3 C12793 complement(1085044..1086129) similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Protein that physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits KLLA0C12815g 0 1086418 1086759 ON 3 C12815 complement(1086418..1086759) similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 Transcription factor IIA small chain KLLA0C12837g 1 1087043 1088317 ON 3 C12837 (1087043..1088317) similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor) plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA contains a putative RNA- binding zinc knuckle motif KLLA0C12859g 0 1088553 1089890 ON 3 C12859 complement(1088553..1089890) similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W High level expression reduced Ty3 Transposition, KLLA0C12881g 1 1090895 1092016 ON 3 C12881 (1090895..1092016) similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells KLLA0C12903g 0 1092251 1093564 ON 3 C12903 complement(1092251..1093564) similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0C12925g 1 1094574 1096286 ON 3 C12925 (1094574..1096286) weakly similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences KLLA0C12947g 1 1096922 1098139 ON 3 C12947 (1096922..1098139) similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles forms a complex with Erv41p involved in the membrane fusion stage of transport KLLA0C12969g 1 1098631 1100904 ON 3 C12969 (1098631..1100904) similar to uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p required for polarity establishment and maintenance and mutants have morphological defects in bud formation and shmooing, KLLA0C12991g 0 1101129 1103114 ON 3 C12991 complement(1101129..1103114) similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W Hypothetical ORF KLLA0C13013g 0 1103930 1105315 ON 3 C13013 complement(1103930..1105315) similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function required for growth on glycerol as a carbon source KLLA0C13035g 0 1106439 1108007 ON 3 C13035 complement(1106439..1108007) conserved hypothetical protein KLLA0C13057g 0 1109343 1110593 ON 3 C13057 complement(1109343..1110593) some similarities with uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 role in cell cycle START involved in G(sub)1 size control G(sub)1 cyclin KLLA0C13079g 0 1113707 1114108 ON 3 C13079 complement(1113707..1114108) no similarity KLLA0C13101g 1 1115573 1117699 ON 3 C13101 (1115573..1117699) weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to mitochondria msc6 mutants are defective in directing meiotic recombination events to homologous chromatids KLLA0C13123g 0 1118007 1118969 ON 3 C13123 complement(1118007..1118969) similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase) attaches heme to apo-Cyc1p in the mitochondrial intermembrane space human ortholog may have a role in microphthalmia with linear skin defects (MLS) KLLA0C13145g 1 1119411 1121789 ON 3 C13145 (1119411..1121789) similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Protein required for cell viability KLLA0C13167g 0 1121827 1122846 ON 3 C13167 complement(1121827..1122846) weakly similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Hypothetical ORF KLLA0C13189g 0 1123917 1124930 ON 3 C13189 complement(1123917..1124930) some similarities with uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose- induced cAMP signaling directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p KLLA0C13211g 1 1126739 1128868 ON 3 C13211 (1126739..1128868) weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Lecine-zipper transcriptional activator responsible for the regulation of the sulfur amino acid pathway requires different combinations of the auxiliary factors Cbf1p Met28p Met31p and Met32p KLLA0C13233g 0 1129020 1129808 ON 3 C13233 complement(1129020..1129808) similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-related protein required for vacuolar assembly PEP12 homolog KLLA0C13255g 1 1130329 1134621 ON 3 C13255 (1130329..1134621) similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase alpha- primase complex required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis KLLA0C13277g 1 1135255 1137420 ON 3 C13277 (1135255..1137420) similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters KLLA0C13299g 1 1137783 1138505 ON 3 C13299 (1137783..1138505) similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W Hypothetical ORF KLLA0C13321g 0 1138666 1139406 ON 3 C13321 complement(1138666..1139406) weakly similar to uniprot|Q12057 Saccharomyces cerevisiae YOR104W PIN2 Protein that induces appearance of [PIN ] prion when overproduced KLLA0C13343g 0 1139922 1140554 ON 3 C13343 complement(1139922..1140554) highly similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase required for cell cycle arrest in response to oxidative damage of DNA KLLA0C13365g 1 1140975 1141355 ON 3 C13365 (1140975..1141355) similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins KLLA0C13387g 0 1142002 1143176 ON 3 C13387 complement(1142002..1142841,1143162..1143176) similar to uniprot|P01120 Saccharomyces cerevisiae YNL098C RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes KLLA0C13409g 0 1143660 1144835 ON 3 C13409 complement(1143660..1144835) some similarities with uniprot|P50947 Saccharomyces cerevisiae YNL097C KLLA0C13431g 1 1145919 1146905 ON 3 C13431 (1145919..1146905) similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta- oxidation KLLA0C13453g 0 1147145 1148365 ON 3 C13453 complement(1147145..1148365) similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family KLLA0C13475g 1 1149711 1152434 ON 3 C13475 (1149711..1152434) weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit involved in protein import/export and in export of RNAs possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC potential Cdc28p substrate KLLA0C13497g 1 1152917 1153396 ON 3 C13497 (1152917..1153396) conserved hypothetical protein KLLA0C13519g 0 1153725 1154808 ON 3 C13519 complement(1153725..1154153,1154665..1154808) highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W KLLA0C13541g 1 1155897 1156721 ON 3 C13541 (1155897..1156721) similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase KLLA0C13563g 0 1157278 1157826 ON 3 C13563 complement(1157278..1157826) highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP- ribosylation factor GTPase of the Ras superfamily involved in development of polarity KLLA0C13585g 1 1159397 1164289 ON 3 C13585 (1159397..1164289) similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Hypothetical ORF KLLA0C13607g 0 1164479 1166092 ON 3 C13607 complement(1164479..1166092) similar to gnl|GLV|CAGL0G06468g Candida glabrata CAGL0G06468g and some similarites with YOR092W uniprot|Q99252 Saccharomyces cerevisiae YOR092W ECM3 Non- essential protein of unknown function KLLA0C13651g 1 1167624 1169333 ON 3 C13651 (1167624..1169333) similar to uniprot|Q75CK0 Ashbya gossypii ACL081C ACL081Cp and weakly similar to YNL094W uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function interacts with Rvs161p and Rvs167p computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization KLLA0C13673g 0 1169503 1170546 ON 3 C13673 complement(1169503..1170546) similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W RBF46 Hypothetical ORF KLLA0C13706g 1 1171272 1172918 ON 3 C13706 (1171272..1172918) similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrially localized type 2C protein phosphatase contains Mg2 /Mn2 -dependent casein phosphatase activity in vitro but in vivo substrates are unknown KLLA0C13728g 1 1173329 1173955 ON 3 C13728 (1173329..1173955) highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C VPS21 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization geranylgeranylated geranylgeranylation required for membrane association KLLA0C13750g 1 1174325 1175512 ON 3 C13750 (1174325..1175512) similar to uniprot|P53934 Saccharomyces cerevisiae YNL092W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0C13772g 0 1175544 1177574 ON 3 C13772 complement(1175544..1177574) similar to uniprot|Q12324 Saccharomyces cerevisiae YOR088W/YOR087W YVC1 Vacuolar cation channel KLLA0C13794g 1 1178848 1182747 ON 3 C13794 (1178848..1182747) some similarities with uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function mediates sensitivity to salt stress interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 KLLA0C13816g 1 1183412 1183975 ON 3 C13816 (1183412..1183975) highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity and in microtubule assembly KLLA0C13838g 1 1184534 1188841 ON 3 C13838 (1184534..1188841) similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Essential type II topoisomerase catalyzes topology changes in DNA via transient breakage and rejoining of phosphodiester bonds in the DNA backbone localizes to axial cores in meiosis KLLA0C13860g 1 1189822 1193343 ON 3 C13860 (1189822..1193343) similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C TCB1 Contains three calcium and lipid binding domains green fluorescent protein (GFP)-fusion protein localizes to the cell periphery C-terminal portion of Tcb1p Tcb2p and Tcb3p interact KLLA0C13882g 1 1193639 1193938 ON 3 C13882 (1193639..1193938) similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W Hypothetical ORF KLLA0C13904g 0 1194035 1195072 ON 3 C13904 complement(1194035..1195072) similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins Ost3p is important for N- glycosylation of a subset of proteins KLLA0C13926g 1 1195709 1198063 ON 3 C13926 (1195709..1198063) similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein involved in propagation of M2 dsRNA satellite of L-A virus forms a complex with Pbp1p that is involved in posttranscriptional regulation of HO endonuclease KLLA0C13948g 0 1198406 1200832 ON 3 C13948 complement(1198406..1200832) similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C PRP12 Integral inner mitochondrial membrane protein with similarity to exonucleases Klac_YGOB_Anc_5.18b 1 1201452 1204954 ON 3 Anc_5.18b (1201452..1202573,1202576..1204954) ANNOTATED BY YGOB - Klac_YGOB_Anc_5.18 1 1202804 1204954 OFF 3 Anc_5.18 (1202804..1204954) ANNOTATED BY YGOB - KLLA0C14003g 0 1204999 1205868 ON 3 C14003 complement(1204999..1205868) similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C Homolog to human PPAT KLLA0C14025g 1 1206080 1207669 ON 3 C14025 (1206080..1207669) weakly similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Essential protein component of a complex containing Cef1p has similarity to S. pombe Cwf22p putative spliceosomal component based on computational analysis of large-scale protein-protein interaction data, KLLA0C14047g 0 1208373 1209509 ON 3 C14047 complement(1208373..1209509) similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C KLLA0C14069g 1 1211025 1216310 ON 3 C14069 (1211025..1216310) similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W GSC2 or uniprot|P38631 Saccharomyces cerevisiae YLR342W FKS1 or uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3, KLLA0C14091g 1 1217374 1219041 ON 3 C14091 (1217374..1219041) similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor KLLA0C14113g 1 1220244 1221869 ON 3 C14113 (1220244..1221869) similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1.3-glucanosyltransferase required for cell wall assembly localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor KLLA0C14135g 0 1221902 1222717 ON 3 C14135 complement(1221902..1222717) similar to uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Protein with a role in maturation of rRNAs and small nucleolar RNAs required for cell viability, KLLA0C14157g 0 1223130 1226402 ON 3 C14157 complement(1223130..1226402) similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex acts as the nuclear import receptor for specific proteins including Pdr1p Yap1p Ste12p and Aft1p KLLA0C14190g 0 1227049 1228836 ON 3 C14190 complement(1227049..1228836) conserved hypothetical protein KLLA0C14212g 0 1229219 1232341 ON 3 C14212 complement(1229219..1232341) weakly similar to uniprot|P25611 Saccharomyces cerevisiae YCR106W RDS1 Regulator of drug sensitivity transcriptional regulator KLLA0C14234g 1 1234598 1238962 ON 3 C14234 (1234598..1238962) similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane transporter of the ATP- binding cassette (ABC) family mediates export of many different organic anions including oligomycin KLLA0C14256g 1 1239373 1240479 ON 3 C14256 (1239373..1240479) similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease 3'- repair diesterase involved in repair of DNA damage by oxidation and alkylating agents controls spontaneous mutations KLLA0C14278g 1 1240990 1242615 ON 3 C14278 (1240990..1242615) similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Protein kinase with a possible role in MAP kinase signaling in the pheromone response pathway KLLA0C14300g 1 1242952 1243842 ON 3 C14300 (1242952..1243842) highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Hypothetical ORF KLLA0C14322g 0 1243993 1244547 ON 3 C14322 complement(1243993..1244547) similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W KLLA0C14344g 1 1245226 1249782 ON 3 C14344 (1245226..1249782) similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C Hypothetical ORF KLLA0C14366g 1 1250171 1251532 ON 3 C14366 (1250171..1251532) similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N- acetylglucosaminyltransferase capable of modification of N- linked glycans in the Golgi apparatus KLLA0C14388g 0 1251548 1252159 ON 3 C14388 complement(1251548..1252159) similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W KLLA0C14410g 1 1254045 1255148 ON 3 C14410 (1254045..1255148) similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase KLLA0C14432g 1 1256193 1257896 ON 3 C14432 (1256193..1257896) similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism involved in response to oxidative stress, Klac_YGOB_KLTH0E14102g 1 1259592 1259786 ON 3 KLTH0E14102g (1259592..1259786) ANNOTATED BY YGOB - KLLA0C14454g 1 1262487 1264399 ON 3 C14454 (1262487..1262544,1263204..1264399) similar to uniprot|P38248 Saccharomyces cerevisiae YBR078w and to uniprot|Q12355 Saccharomyces cerevisiae YDR055w, KLLA0C14476g 0 1265344 1265934 ON 3 C14476 complement(1265344..1265934) conserved hypothetical protein KLLA0C14498g 0 1266410 1269187 ON 3 C14498 complement(1266410..1269187) similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 Subunit of the core complex of translation initiation factor 3(eIF3) essential for translation part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes KLLA0C14520g 0 1269505 1271799 ON 3 C14520 complement(1269505..1271799) highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport homolog of the mammalian NSF KLLA0C14542g 1 1272215 1273195 ON 3 C14542 (1272215..1273195) similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes binds phosphatidylinositol(3)- phosphate contains a FYVE finger domain KLLA0C14564g 1 1273731 1274228 ON 3 C14564 (1273731..1274228) similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function required for growth at high temperature KLLA0C14586g 0 1274520 1275944 ON 3 C14586 complement(1274520..1275944) similar to uniprot|Q12153 Saccharomyces cerevisiae YDR312W SSF2 high copy suppressor of G beta subunit temperature sensitive mutation possibly involved in mating KLLA0C14608g 1 1276354 1277817 ON 3 C14608 (1276354..1277817) highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA RRP3 is a DEAD box gene homologous to eIF-4a which encodes an RNA-dependent ATPase possessing helicase activity which is not specific for RNA KLLA0C14630g 0 1277914 1279776 ON 3 C14630 complement(1277914..1279776) similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes required for nucleotide excision repair target for transcriptional activators KLLA0C14652g 1 1280333 1281970 ON 3 C14652 (1280333..1281970) similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 DnaK homolog interacts with Zuo1p (DnaJ homolog) to form a ribosome-associated complex (RAC) that is bound to the ribosome via the Zuo1p subunit Hsp70 Protein KLLA0C14674g 1 1282309 1283418 ON 3 C14674 (1282309..1283418) similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase part of the pantothenic acid pathway structurally homologous to E. coli panE KLLA0C14696g 1 1284151 1287006 ON 3 C14696 (1284151..1287006) some similarities with uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Suppressor of mar1-1 (sir2) mutation nuclear protein involved in silencing KLLA0C14718g 1 1287448 1288305 ON 3 C14718 (1287448..1288305) similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0C14740g 1 1288826 1289386 ON 3 C14740 (1288826..1289386) no similarity KLLA0C14762g 1 1289858 1290964 ON 3 C14762 (1289858..1290964) weakly similar to uniprot|Q06648 Saccharomyces cerevisiae YDR309C GIC2 Protein of unknown function involved in initiation of budding and cellular polarization interacts with Cdc42p via the Cdc42/Rac- interactive binding (CRIB) domain KLLA0C14784g 0 1291284 1291796 ON 3 C14784 complement(1291284..1291796) weakly similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Protein involved in vacuolar H - ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex KLLA0C14806g 1 1292017 1292448 ON 3 C14806 (1292017..1292448) similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 RNA polymerase II holoenzyme component, KLLA0C14828g 0 1292713 1294602 ON 3 C14828 complement(1292713..1294602) weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Hypothetical ORF KLLA0C14850g 1 1295153 1297036 ON 3 C14850 (1295153..1297036) no similarity KLLA0C14872g 1 1297342 1298298 ON 3 C14872 (1297342..1298298) highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W KLLA0C14894g 0 1298490 1298963 ON 3 C14894 complement(1298490..1298963) similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W Hypothetical ORF KLLA0C14905g 1 1299212 1300276 ON 3 C14905 (1299212..1300276) similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Hypothetical ORF KLLA0C14916g 0 1300320 1300580 ON 3 C14916 complement(1300320..1300580) some similarities with uniprot|Q2V2P7 Saccharomyces cerevisiae YDR461C-A KLLA0C14927g 1 1301197 1301640 ON 3 C14927 (1301197..1301640) similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit KLLA0C14949g 0 1302087 1303895 ON 3 C14949 complement(1302087..1303895) weakly similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W KLLA0C14971g 1 1305101 1306438 ON 3 C14971 (1305101..1306438) some similarities with uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p may partially counteract the action of Vps33p and vice versa localizes to the rim of the vacuole as cells approach stationary phase KLLA0C14993g 0 1306550 1307509 ON 3 C14993 complement(1306550..1307509) conserved hypothetical protein KLLA0C15015g 0 1308053 1308610 ON 3 C15015 complement(1308053..1308610) similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase KLLA0C15037g 1 1309296 1310810 ON 3 C15037 (1309296..1310810) weakly similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C Hypothetical ORF KLLA0C15059g 1 1311550 1313262 ON 3 C15059 (1311550..1313262) uniprot|P78698 Kluyveromyces lactis KLLA0C15059g HEM1 5- aminolevulinate synthase mitochondrial precursor KLLA0C15081g 0 1314304 1315161 ON 3 C15081 complement(1314304..1315161) similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C RTN1 reticulon gene member of the RTNLA (reticulon- like A) subfamily KLLA0C15125g 1 1316235 1318316 ON 3 C15125 (1316235..1318316) highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase catalyzes the conversion of homocitrate to homoisocitrate which is a step in the lysine biosynthesis pathway KLLA0C15147g 1 1319226 1320209 ON 3 C15147 (1319226..1320209) similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Phorphobilinogen deaminase catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane the third step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus expression is regulated by Hap2p-Hap3p KLLA0C15169g 1 1320694 1322343 ON 3 C15169 (1320694..1322343) similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing required for U1 snRNP biogenesis contains multiple tetriatricopeptide repeats KLLA0C15191g 0 1322363 1324417 ON 3 C15191 complement(1322363..1324417) weakly similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function KLLA0C15213g 0 1324914 1325471 ON 3 C15213 complement(1324914..1325471) similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase phosphorylates riboflavin to form riboflavin monophosphate (FMN) which is a necessary cofactor for many enzymes localizes to microsomes and to the mitochondrial inner membrane KLLA0C15235g 0 1325851 1327485 ON 3 C15235 complement(1325851..1327485) similar to uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import component of Nup82p nuclear pore subcomplex contains a nuclear export signal KLLA0C15257g 1 1327926 1328795 ON 3 C15257 (1327926..1328795) highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit KLLA0C15279g 0 1329012 1331927 ON 3 C15279 complement(1329012..1331927) highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Involved in endoplasmic-to-Golgi protein trafficking encodes a subunit of yeast coatomer, KLLA0C15301g 0 1332183 1334285 ON 3 C15301 complement(1332183..1334285) weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Hypothetical ORF KLLA0C15323g 0 1334700 1336088 ON 3 C15323 complement(1334700..1336088) weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 U1 snRNP protein serine-rich has no counterpart in mammalian U1 snRNP KLLA0C15345g 0 1336577 1337026 ON 3 C15345 complement(1336577..1337026) similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins essential for function of H/ACA-type snoRNPs which are involved in 18S rRNA processing Klac_3.trna13Y 1 1337615 1337713 ON 3 tY-GUA (1337615..1337653,1337678..1337713) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.95 KLLA0C15411g 1 1337984 1338997 ON 3 C15411 (1337984..1338997) similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C Klac_YGOB_MFA2 1 1339261 1339359 ON 3 MFA2 (1339261..1339359) ANNOTATED BY YGOB - KLLA0C15433g 0 1339439 1341058 ON 3 C15433 complement(1339439..1341058) similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family involved in RNA isomerization at the 5' splice site KLLA0C15455g 1 1341570 1343270 ON 3 C15455 (1341570..1343270) similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Essential for import of proteins with SKL- like import signal into peroxisomal matrix 69-kDa protein containing tetratricopeptide repeat (TPR) KLLA0C15477g 1 1343847 1344842 ON 3 C15477 (1343847..1344842) uniprot|Q70KX5 Kluyveromyces lactis mnn10 Golgi mannosyltransferase complex subunit KLLA0C15499g 0 1345201 1346715 ON 3 C15499 complement(1345201..1346715) similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis KLLA0C15521g 0 1347098 1348741 ON 3 C15521 complement(1347098..1348741) similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline transporter (permease) that also controls the uptake of nitrogen mustard expression is co- regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol KLLA0C15543g 1 1349181 1352129 ON 3 C15543 (1349181..1352129) similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W mitochondrial protein KLLA0C15565g 0 1352197 1352793 ON 3 C15565 complement(1352197..1352793) similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C KLLA0C15587g 1 1353557 1354111 ON 3 C15587 (1353557..1354111) highly similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Translocase of Outer Mitochondrial membrane KLLA0C15609g 0 1354736 1355074 ON 3 C15609 complement(1354736..1355074) highly similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Hypothetical ORF Klac_3.trna14V 1 1355909 1355982 ON 3 tV-AAC (1355909..1355982) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 KLLA0C15653g 1 1356426 1359467 ON 3 C15653 (1356426..1359467) some similarities with uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Suppressor of Ypt3 KLLA0C15675g 0 1359680 1360015 ON 3 C15675 complement(1359680..1360015) similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 essential zinc finger protein KLLA0C15697g 1 1360289 1361203 ON 3 C15697 (1360289..1361203) similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Protein involved in a putative alcohol- responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain KLLA0C15719g 0 1361328 1362275 ON 3 C15719 complement(1361328..1362275) similar to uniprot|Q75DC1 Ashbya gossypii ABR105C ABR105Cp and weakly similar to YGR080W uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin A member of a conserved family of actin monomer sequestering proteins comprised almost entirely of two tandem repeats each having sequence homology with cofilin (Cof1p) KLLA0C15741g 0 1362669 1363586 ON 3 C15741 complement(1362669..1363586) some similarities with uniprot|P53249 Saccharomyces cerevisiae YGR079W KLLA0C15763g 1 1365488 1367839 ON 3 C15763 (1365488..1367839) similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Hypothetical ORF KLLA0C15785g 0 1367880 1374743 ON 3 C15785 complement(1367880..1374743) similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Central regulator of the Mec1p/Tel1p signaling network; required for mitotic growth, DNA repair and mitotic recombination, regulates phosphorylation of Rad53p, required for dmc1 arrest and meiotic recombination; similar to phosphatidylinositol (PI)3- kinases required for DNA damage induced checkpoint responses in G1, S/M, intra S, and G2/M in mitosis KLLA0C15807g 0 1375152 1375550 ON 3 C15807 complement(1375152..1375550) highly similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Subunit of the Cdc28 protein kinase required for mitotic proteolysis may also be involved in the proteolysis of the G1 cyclins KLLA0C15829g 1 1375908 1378244 ON 3 C15829 (1375908..1378244) similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase, bud neck localization KLLA0C15851g 0 1378324 1380579 ON 3 C15851 complement(1378324..1380579) similar to uniprot|O13585 Saccharomyces cerevisiae YPR089W Hypothetical ORF KLLA0C15873g 1 1381699 1383405 ON 3 C15873 (1381699..1383405) similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 Plasma membrane carnitine transporter expression is down-regulated by osmotic stress also functions as a low-affinity amino acid permease KLLA0C15895g 1 1383929 1385332 ON 3 C15895 (1383929..1385332) highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 RUVB-like protein TIP49b Homologue KLLA0C15917g 0 1385605 1386102 ON 3 C15917 complement(1385605..1386102) highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C TFP3 vacuolar ATPase V0 domain subunit c' KLLA0C15939g 1 1386474 1387124 ON 3 C15939 (1386474..1387124) weakly similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation KLLA0C15961g 1 1387763 1388623 ON 3 C15961 (1387763..1388623) similar to uniprot|P39926 Saccharomyces cerevisiae YMR183C SSO2 encode syntaxin homolog act in late stages of secretion post-Golgi t-SNARE KLLA0C15983g 1 1389936 1395617 ON 3 C15983 (1389936..1395617) similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase which catalyzes the synthesis of long-chain saturated fatty acids contains beta-ketoacyl reductase and beta-ketoacyl synthase activities KLLA0C16005g 1 1397274 1398269 ON 3 C16005 (1397274..1398269) some similarities with uniprot|Q12132 Saccharomyces cerevisiae YPL230W USV1 Up in StarVation KLLA0C16027g 1 1398915 1399481 ON 3 C16027 (1398915..1399481) weakly similar to uniprot|Q99395 Saccharomyces cerevisiae YPL229W Hypothetical ORF KLLA0C16049g 1 1399865 1401535 ON 3 C16049 (1399865..1401535) similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W CET1 Interacts with Ceg1p the mRNA capping enzyme alpha subunit removes gamma-phosphate from triphosphate- terminated RNA mRNA capping enzyme beta subunit RNA 5'- triphosphatase KLLA0C16071g 0 1401692 1402654 ON 3 C16071 complement(1401692..1402654) similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase involved in asparagine-linked glycosylation in the endoplasmic reticulum KLLA0C16093g 0 1403085 1404977 ON 3 C16093 complement(1403085..1404977) weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein required for normal transcription at several loci including HTA2-HTB2 and HHF2- HHT2 but not required at the other histone loci functionally related to Spt10p KLLA0C16115g 1 1405766 1409317 ON 3 C16115 (1405766..1409317) similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion termed [NU] KLLA0C16137g 0 1409593 1410417 ON 3 C16137 complement(1409593..1410417) similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Hypothetical ORF KLLA0C16159g 1 1410778 1411215 ON 3 C16159 (1410778..1411215) highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Hypothetical ORF KLLA0C16181g 0 1411619 1413160 ON 3 C16181 complement(1411619..1413160) similar to uniprot|Q03218 Saccharomyces cerevisiae YMR177W MMT1 Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p, KLLA0C16203g 0 1414169 1418533 ON 3 C16203 complement(1414169..1418533) similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function contains ATP/GTP-binding site motif A null mutant exhibits cellular volume up to four times greater than wild-type also large drooping buds with elongated necks KLLA0C16225g 0 1419986 1420543 ON 3 C16225 complement(1419986..1420543) weakly similar to uniprot|Q08969 Saccharomyces cerevisiae YPL223C Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway KLLA0C16247g 1 1421680 1423089 ON 3 C16247 (1421680..1423089) similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body KLLA0C16269g 0 1423302 1424756 ON 3 C16269 complement(1423302..1424756) similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck KLLA0C16291g 1 1425052 1425749 ON 3 C16291 (1425052..1425072,1425156..1425749) similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Hypothetical ORF KLLA0C16313g 0 1425869 1427194 ON 3 C16313 complement(1425869..1427194) highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Essential, non-ATPase regulatory subunit of the 26S proteasome lid KLLA0C16335g 1 1427751 1430264 ON 3 C16335 (1427751..1430264) similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex which is required for processing of pre- 18S rRNA KLLA0C16357g 0 1430306 1433032 ON 3 C16357 complement(1430306..1433032) similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in formation of Cvt and autophagic vesicles cycles between the pre- autophagosomal structure and other cytosolic punctate structures not found in autophagosomes KLLA0C16379g 0 1433447 1434661 ON 3 C16379 complement(1433447..1434661) similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53 KLLA0C16401g 1 1435065 1436903 ON 3 C16401 (1435065..1436903) similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing essential nucleolar protein that when overproduced disrupts silencing KLLA0C16423g 0 1437001 1439805 ON 3 C16423 complement(1437001..1439805) similar to uniprot|Q12175 Saccharomyces cerevisiae YDL154W MSH5 Protein of the MutS family forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis msh5-Y823H mutation confers tolerance to DNA alkylating agents homologs present in C. elegans and humans KLLA0C16445g 0 1439975 1441309 ON 3 C16445 complement(1439975..1441309) similar to uniprot|P24871 Saccharomyces cerevisiae YLR210W CLB4 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24870 Saccharomyces cerevisiae YDL155W CLB3 KLLA0C16467g 1 1442002 1443825 ON 3 C16467 (1442002..1443825) similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1 2-mannosyltransferase responsible for addition of the second alpha-1 2-linked mannose of the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment KLLA0C16489g 1 1444456 1446642 ON 3 C16489 (1444456..1446642) conserved hypothetical protein KLLA0C16511g 1 1447602 1448327 ON 3 C16511 (1447602..1448327) similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Hypothetical ORF KLLA0C16533g 0 1448866 1450404 ON 3 C16533 complement(1448866..1450404) similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Hypothetical ORF KLLA0C16555g 1 1450673 1450996 ON 3 C16555 (1450673..1450996) similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Hypothetical ORF KLLA0C16577g 0 1451181 1452695 ON 3 C16577 complement(1451181..1452695) similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response where it phosphorylates Fus3p and in the pseudohyphal/invasive growth pathway through phosphorylation of Kss1p phosphorylated by Ste11p degraded by ubiquitin pathway KLLA0C16599g 1 1453655 1455199 ON 3 C16599 (1453655..1455199) similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase stimulates mRNA decapping coordinates distinct steps in mRNA function and decay interacts with both the decapping and deadenylase complexes may have a role in mRNA export and translation KLLA0C16621g 1 1456403 1457323 ON 3 C16621 (1456403..1457323) similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 purine nucleoside phosphorylase specifically metabolizes inosine and guanosine nucleosides KLLA0C16643g 0 1457590 1458498 ON 3 C16643 complement(1457590..1458498) highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p Sec13p Sec16p Sec23p Sec24p Sec31p Sfb2p and Sfb3p) which is important for the formation of ER to Golgi transport vesicles KLLA0C16665g 0 1458916 1461339 ON 3 C16665 complement(1458916..1461339) similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD) forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events KLLA0C16687g 1 1461624 1462820 ON 3 C16687 (1461624..1462820) conserved hypothetical protein KLLA0C16709g 1 1463056 1463295 ON 3 C16709 (1463056..1463295) conserved hypothetical protein KLLA0C16731g 0 1463616 1465052 ON 3 C16731 complement(1463616..1465052) some similarities with uniprot|Q12518 Saccharomyces cerevisiae YDL161W ENT1 KLLA0C16753g 1 1465814 1465987 ON 3 C16753 (1465814..1465987) highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs which are required for pseudouridylation and processing of pre-18S rRNA, KLLA0C16775g 0 1466209 1466427 ON 3 C16775 complement(1466209..1466427) highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore KLLA0C16797g 1 1466983 1469925 ON 3 C16797 (1466983..1469925) some similarities with uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae family members have overlapping redundant functions in sterol metabolism and collectively perform a function essential for viability KLLA0C16819g 1 1470350 1470667 ON 3 C16819 (1470350..1470667) no similarity Klac_YGOB_Anc_8.858 1 1471304 1473029 ON 3 Anc_8.858 (1471304..1471548,1471550..1473029) ANNOTATED BY YGOB - KLLA0C16874g 1 1473776 1475578 ON 3 C16874 (1473776..1473800,1474263..1475578) highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C TUB1 Alpha-tubulin associates with beta- tubulin (Tub2p) to form tubulin dimer which polymerizes to form microtubules KLLA0C16896g 1 1476535 1478112 ON 3 C16896 (1476535..1478112) highly similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1 4-lactone oxidase catalyzes the final step in biosynthesis of D- erythroascorbic acid which is protective against oxidative stress KLLA0C16918g 1 1478540 1479472 ON 3 C16918 (1478540..1479472) similar to uniprot|Q12746 Saccharomyces cerevisiae YML125C Protein required for cell viability KLLA0C16940g 0 1479541 1481469 ON 3 C16940 complement(1479541..1481469) similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein subunit of the Skp1- Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex binds to phosphorylated Ho endonuclease allowing its ubiquitylation by SCF and subsequent degradation Klac_3.trna15I 0 1481672 1481745 ON 3 tI-AAU complement(1481672..1481745) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 KLLA0C16984g 0 1482004 1483650 ON 3 C16984 complement(1482004..1483650) similar to uniprot|P54791 Saccharomyces cerevisiae YPR162C ORC4 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing, KLLA0C17006g 0 1484995 1486968 ON 3 C17006 complement(1484995..1486968) weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C KLLA0C17028g 0 1487806 1489188 ON 3 C17028 complement(1487806..1489188) similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Cystathionine beta-lyase converts cystathionine into homocysteine KLLA0C17050g 1 1490472 1493339 ON 3 C17050 (1490472..1493339) conserved hypothetical protein KLLA0C17072g 1 1494101 1495525 ON 3 C17072 (1494101..1495525) weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Hypothetical ORF KLLA0C17094g 0 1495879 1496556 ON 3 C17094 complement(1495879..1496556) similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division forms a complex with Hop2p which is involved in chromosome pairing and repair of meiotic double-strand breaks KLLA0C17138g 1 1497245 1498396 ON 3 C17138 (1497245..1498396) some similarities with uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Contains a zinc-finger in the N- terminus and a long Gln-rich region in the C-terminus regulates ultradian rhythm cell size cell cycle lifespan sporulation heat tolerance and multidrug transport KLLA0C17160g 1 1498959 1501454 ON 3 C17160 (1498959..1501454) similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein serine/threonine kinase required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway KLLA0C17182g 0 1501733 1503865 ON 3 C17182 complement(1501733..1503865) conserved hypothetical protein KLLA0C17204g 1 1504341 1506647 ON 3 C17204 (1504341..1506647) some similarities with uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport mediates transport between an endosomal compartment and the Golgi contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi KLLA0C17226g 0 1506737 1507705 ON 3 C17226 complement(1506737..1507705) similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase together with Cda1p involved in the biosynthesis ascospore wall component chitosan required for proper rigidity of the ascospore wall KLLA0C17237g 1 1509151 1509396 ON 3 C17237 (1509151..1509396) conserved hypothetical protein KLLA0C17248g 0 1509885 1510439 ON 3 C17248 complement(1509885..1510439) similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p a ubiquitin-like protein to other proteins related to E2 ubiquitin-conjugating enzymes KLLA0C17270g 1 1510929 1512215 ON 3 C17270 (1510929..1512215) no similarity KLLA0C17292g 1 1512447 1518143 ON 3 C17292 (1512447..1518143) similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway required for normal vacuole morphology cell wall integrity and actin cytoskeleton organization KLLA0C17314g 1 1519028 1521394 ON 3 C17314 (1519028..1521394) highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Mitochondrial aconitase required for the tricarboxylic acid (TCA) cycle mutation leads to glutamate auxotrophy KLLA0C17336g 1 1522475 1523923 ON 3 C17336 (1522475..1523923) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport Klac_3.trna16F 1 1524116 1524188 ON 3 tF-GAA (1524116..1524188) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 76.93 KLLA0C17380g 1 1524716 1528075 ON 3 C17380 (1524716..1528075) weakly similar to uniprot|P23201 Saccharomyces cerevisiae YLL021W SPA2 Component of the polarisome which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate KLLA0C17402g 0 1528570 1529295 ON 3 C17402 complement(1528570..1529295) similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit KLLA0C17424g 1 1529941 1531680 ON 3 C17424 (1529941..1531680) similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family required for 18S rRNA synthesis KLLA0C17446g 0 1531978 1532337 ON 3 C17446 complement(1531978..1532337) similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase which is a large enzyme complex required for ATP synthesis associated only with the dimeric form of ATP synthase KLLA0C17468g 0 1532768 1534939 ON 3 C17468 complement(1532768..1534939) similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway KLLA0C17490g 1 1536197 1537555 ON 3 C17490 (1536197..1537555) uniprot|Q70SJ1 Kluyveromyces lactis pcl1 Putative carboxypeptidase-related protein KLLA0C17512g 0 1537707 1540385 ON 3 C17512 complement(1537707..1540385) highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W CDC54 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre- replication complexes on DNA and melt the DNA prior to replication accumulates in the nucleus in G1 homolog of S. pombe Cdc21p KLLA0C17534g 1 1540967 1543984 ON 3 C17534 (1540967..1543984) similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C, KLLA0C17556g 0 1544404 1546227 ON 3 C17556 complement(1544404..1546227) highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Predicted ABC family ATPase required for translation initiation facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit may have a role in large ribosomal subunit biogenesis KLLA0C17578g 1 1547890 1552467 ON 3 C17578 (1547890..1552467) similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Sole S. cerevisiae member of CHD gene family containing Chromodomain Helicase domain and DNA-binding domain transcriptional regulator KLLA0C17600g 1 1553322 1555100 ON 3 C17600 (1553322..1555100) similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein part of the 3'-end RNA-processing complex mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail involved in control of poly(A) tail length interacts with translation factor eIF-4G KLLA0C17622g 1 1555873 1556453 ON 3 C17622 (1555873..1555902,1556004..1556453) highly similar to uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue DNA damage triggers redistribution from the cytoplasm to the nucleus , KLLA0C17644g 1 1557138 1561868 ON 3 C17644 (1557138..1561868) similar to uniprot|P32660 Saccharomyces cerevisiae YER166W DNF1 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the plasma membrane and late exocytic or early endocytic membranes likely involved in protein transport KLLA0C17666g 1 1562996 1565368 ON 3 C17666 (1562996..1565368) some similarities with uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway which controls cell integrity overproduction suppresses pkc1 mutations KLLA0C17688g 0 1565906 1567375 ON 3 C17688 complement(1565906..1567375) uniprot|Q9HGK5 Kluyveromyces lactis CCA1 TRNA nucleotidyltransferase KLLA0C17710g 1 1569331 1571796 ON 3 C17710 (1569331..1571796) similar to uniprot|Q74ZT1 Ashbya gossypii AGR117C AGR117Cp and some similarites with YER169W uniprot|P39956 Saccharomyces cerevisiae YER169W RPH1 Transcriptional repressor of PHR1 which is a photolyase induced by DNA damage binds to AG(4) (C(4)T) sequence upstream of PHR1 Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway KLLA0C17732g 0 1572115 1575699 ON 3 C17732 complement(1572115..1575699) similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs potentially phosphorylated by Cdc28p KLLA0C17754g 1 1576357 1577040 ON 3 C17754 (1576357..1577040) similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase catalyzes the reversible synthesis of GTP and AMP from GDP and ADP may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions 3' sequence of ADK2 varies with strain background KLLA0C17776g 1 1577323 1579659 ON 3 C17776 (1577323..1579659) highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase involved in nucleotide excision repair and transcription subunit of RNA polymerase II transcription initiation factor TFIIH subunit of Nucleotide Excision Repair Factor 3 (NEF3) homolog of human XPD protein KLLA0C17798g 0 1579752 1586201 ON 3 C17798 complement(1579752..1586201) similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase involved in the facilitation and disruption of snRNA interactions required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis KLLA0C17820g 1 1586564 1588510 ON 3 C17820 (1586564..1588510) similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints subunit of a clamp loader that loads Rad17p- Mec3p-Ddc1p onto DNA homolog of human and S. pombe Rad17 protein KLLA0C17842g 0 1588951 1589745 ON 3 C17842 complement(1588951..1589745) similar to uniprot|Q03835 Saccharomyces cerevisiae YDR098C GRX3 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase monothiol glutaredoxin subfamily member along with Grx4p and Grx5p protects cells from oxidative damage KLLA0C17864g 0 1590736 1591629 ON 3 C17864 complement(1590736..1591629) similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase Klac_3.trna17Q 0 1592133 1592204 ON 3 tQ-UUG complement(1592133..1592204) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 70.23 Klac_3.trna18V 0 1592616 1592689 ON 3 tV-AAC complement(1592616..1592689) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 KLLA0C17930g 1 1592949 1593823 ON 3 C17930 (1592949..1593089,1593200..1593823) weakly similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W KLLA0C17941g 0 1593820 1594413 ON 3 C17941 complement(1593820..1594413) similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Hypothetical ORF KLLA0C17963g 1 1594915 1595838 ON 3 C17963 (1594915..1595838) similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Hypothetical ORF KLLA0C17985g 0 1596320 1599046 ON 3 C17985 complement(1596320..1599046) some similarities with uniprot|P32334 Saccharomyces cerevisiae YGR014W MSB2 Mucin family member at the head of the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway also functions as an osmosensor in parallel to the Sho1p-mediated pathway potential Cdc28p substrate KLLA0C18007g 0 1599968 1601674 ON 3 C18007 complement(1599968..1601674) weakly similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 associated with U1 snRNP (no counterpart in mammalian U1 snRNP contains few SR- RE- and RD-dipeptides U1 snRNP protein KLLA0C18029g 0 1601829 1602983 ON 3 C18029 complement(1601829..1602983) similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF KLLA0C18051g 0 1603208 1604557 ON 3 C18051 complement(1603208..1604557) highly similar to uniprot|Q06178 Saccharomyces cerevisiae YLR328W NMA1 Nicotinic acid mononucleotide adenylyltransferase involved in NAD( ) salvage pathway, Klac_3.trna19S 0 1604950 1605044 ON 3 tS-GCU complement(1604950..1604994,1605008..1605044) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 70.94 KLLA0C18117g 1 1605788 1606012 ON 3 C18117 (1605788..1606012) similar to uniprot|Q06177 Saccharomyces cerevisiae YLR327C RBF9 Hypothetical ORF KLLA0C18139g 0 1606193 1607119 ON 3 C18139 complement(1606193..1607119) similar to uniprot|P33412 YGR007W Saccharomyces cerevisiae MUQ1 Choline phosphate cytidylyltransferase, KLLA0C18161g 0 1607267 1607968 ON 3 C18161 complement(1607267..1607968) similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Hypothetical ORF KLLA0C18172g 0 1608010 1608468 ON 3 C18172 complement(1608010..1608468) some similarities with uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing recruited to the spliceosome by Slu7p KLLA0C18194g 1 1608722 1609888 ON 3 C18194 (1608722..1609888) similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 transcription initiation factor TFIIF middle subunit KLLA0C18216g 1 1610542 1610778 ON 3 C18216 (1610542..1610778) highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit KLLA0C18238g 0 1611376 1612956 ON 3 C18238 complement(1611376..1612956) similar to uniprot|Q06169 Saccharomyces cerevisiae YLR324W PEX30 Peroxisomal integral membrane protein involved in negative regulation of peroxisome number partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p KLLA0C18260g 1 1613311 1614000 ON 3 C18260 (1613311..1614000) similar to uniprot|Q752S4 Ashbya gossypii AFR499C CWC24 Pre-mRNA-splicing factor CWC24 and some similarites with YLR323C uniprot|P53769 Saccharomyces cerevisiae KLLA0C18282g 0 1614045 1616252 ON 3 C18282 complement(1614045..1616252) similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W KLLA0C18315g 1 1616549 1618042 ON 3 C18315 (1616549..1618042) similar to uniprot|Q752S6 Ashbya gossypii AFR497C SWC4 SWR1-complex protein 4 and weakly similar to YGR002C uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin component of the NuA4 histone acetyltransferase complex KLLA0C18337g 0 1618091 1622449 ON 3 C18337 complement(1618091..1622449) weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein involved in resistance to ionizing radiation acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks KLLA0C18359g 1 1622747 1624840 ON 3 C18359 (1622747..1624840) similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein involved in actin cable nucleation and polarized cell growth isolated as bipolar budding mutant potential Cdc28p substrate KLLA0C18381g 0 1624865 1627450 ON 3 C18381 complement(1624865..1627450) similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme essential for telomerase core catalytic activity involved in other aspects of telomerase assembly and function KLLA0C18403g 1 1627733 1628719 ON 3 C18403 (1627733..1628719) similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 tRNA-specific adenosine-34 deaminase subunit Tad3p KLLA0C18425g 0 1628725 1629180 ON 3 C18425 complement(1628725..1629180) conserved hypothetical protein KLLA0C18447g 0 1629477 1630805 ON 3 C18447 complement(1629477..1630805) similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Involved in chromatin modeling cell cycle progression homolog of Snf5p member of the chromatin remodeling complex RSC KLLA0C18469g 1 1631528 1632441 ON 3 C18469 (1631528..1631607,1631898..1632441) highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta KLLA0C18491g 1 1632791 1636387 ON 3 C18491 (1632791..1636387) similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 involved in vacuolar protein sorting required for localization and trafficking of the CPY sorting receptor Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2 binding motif. KLLA0C18513g 0 1636434 1637489 ON 3 C18513 complement(1636434..1637489) highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis Klac_CEN3 1 1638151 1638347 ON 3 CEN3 (1638151..1638347) Chromosome III centromere KLLA0C18546g 1 1638916 1639314 ON 3 C18546 (1638916..1639314) highly similar to uniprot|P53738 YNR046W Saccharomyces cerevisiae TRM112 Protein required for cell viability, KLLA0C18568g 1 1639958 1642282 ON 3 C18568 (1639958..1642282) similar to uniprot|P53739 Saccharomyces cerevisiae YNR047W Putative protein kinase that when overexpressed interferes with pheromone-induced growth arrest localizes to the cytoplasm potential Cdc28p substrate and to YCR091W uniprot|P25341 Saccharomyces cerevisiae YCR091W KIN82 Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily KLLA0C18590g 0 1642291 1645380 ON 3 C18590 complement(1642291..1645380) similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends contains a PCNA (Pol30p) binding motif required for genome stability, KLLA0C18612g 1 1646511 1652933 ON 3 C18612 (1646511..1652933) similar to uniprot|P25655 YCR093W Saccharomyces cerevisiae CDC39 Component of the CCR4-NOT complex regulating mRNA levels KLLA0C18634g 1 1653295 1654455 ON 3 C18634 (1653295..1654455) similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W CDC50 Endosomal protein that regulates cell polarity KLLA0C18656g 1 1654787 1655473 ON 3 C18656 (1654787..1655473) highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins plays a role in vesicle biogenesis and ER- associated protein degradation (ERAD) component of the cellular stress response KLLA0C18678g 0 1655735 1657387 ON 3 C18678 complement(1655735..1657387) similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF KLLA0C18700g 0 1658267 1662133 ON 3 C18700 complement(1658267..1662133) similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF KLLA0C18711g 1 1662320 1662484 ON 3 C18711 (1662320..1662484) no similarity KLLA0C18722g 0 1662508 1663107 ON 3 C18722 complement(1662508..1663107) similar to uniprot|Q9UVP9 Saccharomyces kluyveri Hypothetical protein and some similarites with YNR049C uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of the secretory vesicle docking complex acts at a late step in secretion shows genetic and physical interactions with Sec1p and is enriched in microsomal membrane fractions required for sporulation KLLA0C18744g 0 1663510 1664847 ON 3 C18744 complement(1663510..1664847) highly similar to uniprot|P38999 YNR050C Saccharomyces cerevisiae LYS9 Saccharopine dehydrogenase (NADP L- glutamate-forming) KLLA0C18755g 1 1664912 1665268 ON 3 C18755 (1664912..1665268) no similarity KLLA0C18777g 0 1665876 1666901 ON 3 C18777 complement(1665876..1666901) similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0C18799g 0 1667314 1668795 ON 3 C18799 complement(1667314..1668795) some similarities with uniprot|P53741 YNR051C Saccharomyces cerevisiae BRE5 Ubiquitin protease cofactor, KLLA0C18821g 0 1669647 1670990 ON 3 C18821 complement(1669647..1670990) similar to uniprot|P39008 YNR052C Saccharomyces cerevisiae POP2 RNase of the DEDD superfamily subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation KLLA0C18843g 0 1671445 1673466 ON 3 C18843 complement(1671445..1672179,1672660..1673466) highly similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation, KLLA0C18865g 0 1673836 1674717 ON 3 C18865 complement(1673836..1674717) some similarities with uniprot|P53743 YNR054C Saccharomyces cerevisiae ESF2 Essential nucleolar protein involved in pre-18S rRNA processing KLLA0C18887g 1 1675383 1676435 ON 3 C18887 (1675383..1676435) similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Hypothetical ORF KLLA0C18909g 0 1676552 1678630 ON 3 C18909 complement(1676552..1678630) similar to uniprot|Q59UP3 Candida albicans DUR34 Potential urea active transport protein and weakly similar to YHL016C uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway KLLA0C18931g 1 1680133 1681794 ON 3 C18931 (1680133..1681794) uniprot|Q874B4 Kluyveromyces lactis KLLA0C18931g Drug efflux permease KNQ1 KLLA0C18953g 1 1682246 1684357 ON 3 C18953 (1682246..1684357) some similarities with uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type KLLA0C18975g 0 1684573 1688433 ON 3 C18975 complement(1684573..1688433) highly similar to uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF KLLA0C18997g 0 1688974 1689318 ON 3 C18997 complement(1688974..1689318) no similarity KLLA0C19019g 1 1689555 1691090 ON 3 C19019 (1689555..1691090) similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease KLLA0C19041g 0 1691258 1692091 ON 3 C19041 complement(1691258..1692091) conserved hypothetical protein KLLA0C19063g 0 1692492 1693121 ON 3 C19063 complement(1692492..1693121) conserved hypothetical protein KLLA0C19085g 0 1694739 1695761 ON 3 C19085 complement(1694739..1695761) highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP) member of a subtelomeric gene family including THI5 THI11 THI12 and THI13 KLLA0C19107g 0 1696925 1698556 ON 3 C19107 complement(1696925..1698556) weakly similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase converts allantoin to allantoate in the first step of allantoin degradation expression sensitive to nitrogen catabolite repression, KLLA0C19132g 1 1699729 1699998 ON 3 C19132 (1699729..1699998) no similarity KLLA0C19184g 1 1709494 1710936 ON 3 C19184 (1709494..1710936) no similarity KLLA0C19206g 1 1711813 1713348 ON 3 C19206 (1711813..1713348) similar to uniprot|Q5MBU0 Aspergillus fumigatus gliC GliC KLLA0C19228g 1 1713787 1715562 ON 3 C19228 (1713787..1715562) similar to uniprot|P53749 Saccharomyces cerevisiae YNR063W Hypothetical ORF KLLA0C19250g 1 1716088 1717470 ON 3 C19250 (1716088..1717470) similar to uniprot|P53748 Saccharomyces cerevisiae YNR062C Hypothetical ORF KLLA0C19272g 0 1717903 1719774 ON 3 C19272 complement(1717903..1719774) similar to uniprot|P38724 Saccharomyces cerevisiae YHL047C ARN2 Transporter or YHL040C uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to the siderophore triacetylfusarinine C, KLLA0C19316g 1 1722987 1725086 ON 3 C19316 (1722987..1725086) some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C KLLA0C19327g 0 1727158 1727597 ON 3 C19327 complement(1727158..1727508,1727595..1727597) some similarities with uniprot|P53054 Saccharomyces cerevisiae YGL262W Hypothetical ORF KLLA0C19338g 1 1729569 1730978 ON 3 C19338 (1729569..1730978) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin KLLA0C19360g 0 1731276 1732223 ON 3 C19360 complement(1731276..1732223) highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid dihydroorotate dehydrogenase KLLA0C19382g 0 1733084 1734340 ON 3 C19382 complement(1733084..1734340) similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W KLLA0C19437g 1 1740718 1743105 ON 3 C19437 (1740718..1743105) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) KLLA0C19547g 1 1750548 1751549 ON 3 C19547 (1750548..1751549) weakly similar to uniprot|Q55924 Synechocystis sp slr0317 Slr0317 protein KLLA0D00143g 1 4326 5849 ON 4 D00143 (4326..5849) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0D00157g 0 6536 6754 ON 4 D00157 complement(6536..6754) conserved hypothetical protein KLLA0D00187g 1 7837 8277 ON 4 D00187 (7837..8277) no similarity KLLA0D00209g 0 8764 9141 ON 4 D00209 complement(8764..9141) conserved hypothetical protein KLLA0D00231g 0 9854 11626 ON 4 D00231 complement(9854..11626) uniprot|Q9Y844 Kluyveromyces lactis mal22 Maltase, KLLA0D00253g 1 12804 14534 ON 4 D00253 (12804..14534) highly similar to uniprot|Q9Y845 Kluyveromyces lactis mal21 Maltose permease KLLA0D00258g 0 15217 16671 ON 4 D00258 complement(15217..16671) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin KLLA0D00264g 0 18273 21287 ON 4 D00264 complement(18273..21287) some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C KLLA0D00269g 0 22009 22491 ON 4 D00269 complement(22009..22491) no similarity KLLA0D00275g 0 24448 25623 ON 4 D00275 complement(24448..25623) some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C KLLA0D00330g 0 26976 29273 ON 4 D00330 complement(26976..29273) similar to uniprot|P07337 Kluyveromyces marxianus Beta- glucosidase precursor KLLA0D00352g 0 29820 30341 ON 4 D00352 complement(29820..30341) no similarity KLLA0D00374g 1 30962 32632 ON 4 D00374 (30962..32632) similar to gnl|GLV|DEHA0G07139g Debaryomyces hansenii DEHA0G07139g and weakly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions KLLA0D00396g 0 36277 37362 ON 4 D00396 complement(36277..37362) conserved hypothetical protein KLLA0D00418g 1 38504 39238 ON 4 D00418 (38504..39238) some similarities with uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms putative translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import KLLA0D00440g 0 39291 40289 ON 4 D00440 complement(39291..40289) similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease has RNAse and DNA endo- and exonucleolytic activities has a role in mitochondrial recombination KLLA0D00462g 1 41415 43202 ON 4 D00462 (41415..43202) similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation repairs pyrimidine dimers in the presence of visible light induced by DNA damage regulated by transcriptional repressor Rph1p KLLA0D00484g 1 44879 47893 ON 4 D00484 (44879..47893) conserved hypothetical protein KLLA0D00506g 0 48092 49318 ON 4 D00506 complement(48092..49318) conserved hypothetical protein KLLA0D00528g 1 51518 54526 ON 4 D00528 (51518..54526) similar to uniprot|Q75C89 Ashbya gossypii ACR027C ACR027Cp and some similarities with uniprot|P28273 YKL215C Saccharomyces cerevisiae Hypothetical ORF KLLA0D00550g 0 55088 56827 ON 4 D00550 complement(55088..56827) weakly similar to uniprot|Q08579 YOR192C Saccharomyces cerevisiae Hypothetical ORF KLLA0D00572g 0 57285 57704 ON 4 D00572 complement(57285..57704) some similarities with uniprot|Q12090 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases KLLA0D00594g 0 57894 58856 ON 4 D00594 complement(57894..58856) highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase responsible for conserved m6(2)Am6(2)A dimethylation in 3'- terminal loop of 18 S rRNA part of 90S and 40S pre- particles in nucleolus involved in pre-ribosomal RNA processing KLLA0D00616g 0 59155 59844 ON 4 D00616 complement(59155..59844) similar to uniprot|Q08981 Saccharomyces cerevisiae YPL267W ACM1 Protein of unknown function potential Cdc28p substrate, KLLA0D00638g 0 60190 63120 ON 4 D00638 complement(60190..63120) similar to uniprot|Q75C92 Ashbya gossypii ACR024W ACR024Wp and weakly similar to YPL268W uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phosphoinositide- specific phospholipase C hydrolyzes phosphatidylinositol 4 5-biphosphate (PIP2) to generate inositol 1 4 5- triphosphate (IP3) and 1 2-diacylglycerol (DAG) involved in kinetochore function and pseudohyphal differentiation, KLLA0D00660g 1 63920 64846 ON 4 D00660 (63920..64846) no similarity KLLA0D00682g 1 65058 65771 ON 4 D00682 (65058..65771) highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C KLLA0D00704g 1 66841 67554 ON 4 D00704 (66841..67554) highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C KLLA0D00726g 0 67744 69450 ON 4 D00726 complement(67744..69450) weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase KLLA0D00748g 0 69839 72208 ON 4 D00748 complement(69839..72208) similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Half-type ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane Klac_YGOB_Anc_6.6 0 72752 72937 ON 4 Anc_6.6 complement(72752..72937) ANNOTATED BY YGOB - KLLA0D00792g 1 73422 76484 ON 4 D00792 (73422..76484) similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C KLLA0D00814g 0 76687 77913 ON 4 D00814 complement(76687..77913) similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W KLLA0D00836g 0 78202 80124 ON 4 D00836 complement(78202..80124) similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function KLLA0D00858g 0 80327 81952 ON 4 D00858 complement(80327..81952) similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase a hexosephosphate mutase involved in the biosynthesis of chitin KLLA0D00880g 1 82211 82426 ON 4 D00880 (82211..82426) uniprot|P78699 Kluyveromyces lactis KLLA0D00880g SOM1 Protein SOM1 mitochondrial precursor KLLA0D00902g 1 83648 85126 ON 4 D00902 (83648..85126) highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase converts fumaric acid to L-malic acid in the TCA cycle cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation Klac_4.trna1L 0 85441 85556 ON 4 tL-CAA complement(85441..85484,85519..85556) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.66 KLLA0D00979g 1 86703 88388 ON 4 D00979 (86703..88388) similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C PRB1 Vacuolar proteinase B (yscB) a serine protease of the subtilisin family involved in protein degradation in the vacuole and required for full protein degradation during sporulation KLLA0D01001g 1 88911 89600 ON 4 D01001 (88911..89600) conserved hypothetical protein KLLA0D01023g 1 89887 90693 ON 4 D01023 (89887..90693) similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W Protein required for cell viability KLLA0D01045g 1 91110 94007 ON 4 D01045 (91110..94007) similar to uniprot|Q8J1G7 Ashbya gossypii ACR010C CIN8 Kinesin-like protein CIN8 and some similarites with YEL061C uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation KLLA0D01067g 0 94114 96096 ON 4 D01067 complement(94114..96096) similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Regulator of nitrogen permeases transcription is induced in response to proline and urea contains two PEST sequences KLLA0D01089g 0 97438 100161 ON 4 D01089 complement(97438..100161) similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end- joining (NHEJ) forms stable heterodimer with required cofactor Lif1p catalyzes DNA ligation as part of a complex with Lif1p and Nej1p involved in meiosis not essential for vegetative growth KLLA0D01111g 0 100315 101259 ON 4 D01111 complement(100315..101259) similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C Hypothetical ORF KLLA0D01133g 1 101580 104783 ON 4 D01133 (101580..104783) some similarities with uniprot|Q04257 Saccharomyces cerevisiae YML002W and some similarities with uniprot|Q04257 Saccharomyces cerevisiae YML003W Hypothetical ORF KLLA0D01155g 0 104847 105854 ON 4 D01155 complement(104847..105854) similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein of unknown function contains tetratricopeptide (TPR) repeats which often mediate protein-protein interactions conserved in human and C. elegans Klac_4.trna2R 0 106277 106366 ON 4 tR-ACG complement(106277..106312,106330..106366) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 65.75 KLLA0D01221g 0 106736 108436 ON 4 D01221 complement(106736..108436) similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Glucosyltransferase involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation mutations in human ortholog are associated with disease, KLLA0D01243g 0 108848 109783 ON 4 D01243 complement(108848..109783) conserved hypothetical protein KLLA0D01265g 1 110784 111407 ON 4 D01265 (110784..111407) highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Gtp-binding protein of the rab family required for homotypic fusion event in vacuole inheritance for endosome-endosome fusion and for fusion of endosomes to vacuoles when expressed from high copy plasmid GTP-binding protein rab family KLLA0D01287g 1 112866 113903 ON 4 D01287 (112866..113903) similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin negatively regulates phosphate metabolism Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p deletion of PHO80 leads to aminoglycoside supersensitivity truncated form of PHO80 affects vacuole inheritance KLLA0D01309g 1 114713 116947 ON 4 D01309 (114713..116947) similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Exonuclease component of the nuclear exosome contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus KLLA0D01331g 1 117469 118395 ON 4 D01331 (117469..118395) similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Membrane protein involved in zinc metabolism member of the four-protein IZH family direct target of the Zap1p transcription factor expression induced by zinc deficiency and fatty acids deletion increases sensitivity to elevated zinc Klac_4.trna3T 0 118602 118674 ON 4 tT-AGU complement(118602..118674) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 KLLA0D01386g 1 118965 120434 ON 4 D01386 (118965..120434) similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA Initiator methionine tRNA 2'-O-ribosyl phosphate transferase KLLA0D01408g 1 120712 122268 ON 4 D01408 (120712..122268) weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein likely involved in translation of the mitochondrial OLI1 mRNA exhibits genetic interaction with the OLI1 mRNA 5'- untranslated leader KLLA0D01430g 0 122369 123160 ON 4 D01430 complement(122369..123160) similar to uniprot|Q75DZ3 Ashbya gossypii ABL120W ABL120Wp and weakly similar to YMR281W uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly the de- N-acetylation of the N- acetylglucosaminylphosphatidylinositol intermediate functional homolog of human PIG-Lp KLLA0D01452g 1 124018 128355 ON 4 D01452 (124018..128355) similar to uniprot|Q75DZ4 Ashbya gossypii ABL121C ABL121Cp and similar to YMR280C uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator KLLA0D01485g 1 129351 132806 ON 4 D01485 (129351..132806) similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein based on computational analysis of large-scale protein-protein interaction data KLLA0D01507g 1 133636 135183 ON 4 D01507 (133636..135183) weakly similar to uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease KLLA0D01529g 0 135998 137503 ON 4 D01529 complement(135998..137503) similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Mannosyltransferase with a role in protein N- glycosylation KLLA0D01551g 0 137965 138960 ON 4 D01551 complement(137965..138960) highly similar to uniprot|Q08985 Saccharomyces cerevisiae YPL273W SAM4 S-adenosylmethionine-homocysteine methyltransferase, KLLA0D01573g 0 139183 141006 ON 4 D01573 complement(139183..141006) similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W Hypothetical ORF KLLA0D01595g 0 141459 143618 ON 4 D01595 complement(141459..143618) similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase , KLLA0D01617g 0 143940 145628 ON 4 D01617 complement(143940..145628) weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa) involved in RNA polymerase II transcription initiation KLLA0D01639g 0 146344 147489 ON 4 D01639 complement(146344..147489) similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Required for the hydroxylation of the very long chain fatty acid (VLCFA) located in the endoplasmic reticulum desaturase/hydroxylase enzyme KLLA0D01661g 0 148193 148531 ON 4 D01661 complement(148193..148531) similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W defines a new subfamily of the split beta-alpha- beta sandwiches. KLLA0D01683g 0 148855 151689 ON 4 D01683 complement(148855..151689) some similarities with uniprot|P54786 Saccharomyces cerevisiae YML109W ZDS2 Protein that interacts with silencing proteins at the telomere involved in transcriptional silencing paralog of Zds1p and with YMR273C uniprot|P50111 Saccharomyces cerevisiae YMR273C ZDS1 Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; also has a role in localization of Bcy1p, which is a regulatory subunit of protein kinase A; paralog of Zds2p KLLA0D01705g 0 152307 153272 ON 4 D01705 complement(152307..153272) similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease Klac_4.trna4P 1 154028 154149 ON 4 tP-UGG (154028..154063,154114..154149) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 60.36 KLLA0D01771g 1 154445 155359 ON 4 D01771 (154445..155359) highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1 4- benzoquinone methyltransferase involved in ubiquinone (Coenzyme Q) biosynthesis located in mitochondria KLLA0D01793g 0 155616 158402 ON 4 D01793 complement(155616..158402) similar to uniprot|Q03758 Saccharomyces cerevisiae YML111W BUL2 Component of the Rsp5p E3-ubiquitin ligase complex involved in intracellular amino acid permease sorting functions in heat shock element mediated gene expression essential for growth in stress conditions functional homolog of BUL1 KLLA0D01815g 0 158846 159916 ON 4 D01815 complement(158846..159916) similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing, KLLA0D01837g 0 160236 161006 ON 4 D01837 complement(160236..161006) similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA). oligo(dT) tracts; Arg side chain in its N- terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability KLLA0D01859g 1 161628 162743 ON 4 D01859 (161628..162743) similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin- binding protein required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle involved in proteolysis interacts with the proteasome KLLA0D01881g 0 162870 163847 ON 4 D01881 complement(162870..163847) weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery KLLA0D01903g 1 164524 165204 ON 4 D01903 (164524..165204) highly similar to uniprot|P13298 Saccharomyces cerevisiae YML106W URA5 Fifth step in pyrimidine biosynthesis pathway Orotate phosphoribosyltransferase 1, KLLA0D01925g 0 165317 166129 ON 4 D01925 complement(165317..166129) similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 signal recognition particle subunit homologue of mammalian SRP19 KLLA0D01947g 1 166415 167653 ON 4 D01947 (166415..167653) similar to uniprot|Q756W7 Ashbya gossypii AER288C AER288Cp and weakly similar to YMR270C uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Upstream activation factor subunit KLLA0D01958g 0 167629 171015 ON 4 D01958 complement(167629..171015) similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein required for nuclear and mitochondrial transmission to daughter buds, KLLA0D01980g 0 171236 171784 ON 4 D01980 complement(171236..171784) conserved hypothetical protein KLLA0D02002g 1 173117 173563 ON 4 D02002 (173117..173563) conserved hypothetical protein KLLA0D02024g 0 173877 175547 ON 4 D02024 complement(173877..175547) similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane KLLA0D02046g 0 175907 176644 ON 4 D02046 complement(175907..176644) highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016c TIF6 translation initiation factor 6 (eIF6) singleton, KLLA0D02068g 1 177264 178481 ON 4 D02068 (177264..178481) conserved hypothetical protein KLLA0D02090g 1 178880 180688 ON 4 D02090 (178880..180688) some similarities with uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Chromatin Assembly Complex subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I) p90 subunit of yeast Chromatin Assembly Factor-I (CAF-I) KLLA0D02112g 1 181482 182015 ON 4 D02112 (181482..182015) some similarities with uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF KLLA0D02134g 0 182345 184033 ON 4 D02134 complement(182345..184033) highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase responsible along with Lcb1p for the first committed step in sphingolipid synthesis which is the condensation of serine with palmitoyl-CoA to form 3- ketosphinganine KLLA0D02156g 0 184520 186085 ON 4 D02156 complement(184520..186085) similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Mitochondrial protein member of the ATP-binding cassette (ABC) transporter family transcriptionally activated by Yrm1p along with genes involved in multidrug resistance KLLA0D02178g 1 186452 187303 ON 4 D02178 (186452..187303) similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Hypothetical ORF KLLA0D02200g 0 187364 187912 ON 4 D02200 complement(187364..187912) similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W (VPS51) KLLA0D02222g 1 188350 190266 ON 4 D02222 (188350..190266) weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W TAX4 and to uniprot|P36115 Saccharomyces cerevisiae YKR019C IRS4 KLLA0D02244g 1 190557 192734 ON 4 D02244 (190557..192734) similar to uniprot|P36114 Saccharomyces cerevisiae YKR018C Hypothetical ORF KLLA0D02266g 1 193082 194587 ON 4 D02266 (193082..194587) similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Hypothetical ORF KLLA0D02288g 0 194724 196286 ON 4 D02288 complement(194724..196286) similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes KLLA0D02310g 0 196687 198294 ON 4 D02310 complement(196687..198294) similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FMP13 The authentic non-tagged protein was localized to the mitochondria KLLA0D02332g 1 198735 199220 ON 4 D02332 (198735..199220) no similarity KLLA0D02354g 1 199795 201057 ON 4 D02354 (199795..201057) conserved hypothetical protein KLLA0D02376g 1 201512 202135 ON 4 D02376 (201512..202135) similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 rab5-like GTPase involved in vacuolar protein sorting and endocytosis probable purine nucleotide- binding protein KLLA0D02398g 0 202446 206063 ON 4 D02398 complement(202446..206063) similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes involved in control of mitotic chromsome transmission, KLLA0D02420g 0 206544 207182 ON 4 D02420 complement(206544..207182) some similarities with uniprot|P36110 Saccharomyces cerevisiae YKR013W PRY2 Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins KLLA0D02442g 0 207613 208719 ON 4 D02442 complement(207613..208719) some similarities with uniprot|P47032 Saccharomyces cerevisiae YJL079C PRY1 Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins KLLA0D02464g 0 209705 210388 ON 4 D02464 complement(209705..210388) similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Hypothetical ORF KLLA0D02486g 1 210629 211615 ON 4 D02486 (210629..211615) similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family KLLA0D02508g 1 211891 212358 ON 4 D02508 (211891..212358) highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit KLLA0D02530g 0 212703 214826 ON 4 D02530 complement(212703..214826) similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity KLLA0D02552g 0 215290 217149 ON 4 D02552 complement(215290..217149) similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 DNA-3-methyladenine glycosidase II that catalyzes of the hydrolysis of alkylated DNA KLLA0D02574g 1 217940 218449 ON 4 D02574 (217940..218449) similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC25 KLLA0D02596g 0 218659 219782 ON 4 D02596 complement(218659..219586,219682..219782) similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W Hypothetical ORF KLLA0D02618g 0 220267 224253 ON 4 D02618 complement(220267..224253) similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rhop1 activity as part of the cell integrity signaling pathway multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation potential Cdc28p substrate, KLLA0D02640g 0 225482 227251 ON 4 D02640 complement(225482..227251) similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase) component of the mitochondrial intermembrane space required for lactate utilization expression is repressed by glucose and anaerobic conditions Klac_4.trna5N 1 228254 228327 ON 4 tN-GUU (228254..228327) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 KLLA0D02684g 0 228564 229166 ON 4 D02684 complement(228564..229166) highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 v-SNARE (synaptobrevin) essential for endoplasmic reticulum-Golgi transport KLLA0D02706g 1 229566 230786 ON 4 D02706 (229566..230786) some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space involved in import and assembly of intermembrane space proteins KLLA0D02728g 0 231163 233166 ON 4 D02728 complement(231163..233166) weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein present in native splicing complexes identified as a suppressor of prp38-1 a spliceosomal maturation mutation cold sensitive alleles accumulate pre-mRNA KLLA0D02750g 1 233381 234652 ON 4 D02750 (233381..234652) similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Protein that interacts with and is required for activation of Apg1p protein kinase involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway KLLA0D02772g 0 234761 236146 ON 4 D02772 complement(234761..236146) similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase, KLLA0D02794g 0 236488 237846 ON 4 D02794 complement(236488..237846) similar to uniprot|P53960 Saccharomyces cerevisiae YNL040W Hypothetical ORF KLLA0D02816g 0 238050 239138 ON 4 D02816 complement(238050..239138) similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Regulatory subunit of Glc7p type1 protein phosphatase KLLA0D02838g 0 239515 239880 ON 4 D02838 complement(239515..239880) similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein involved in biosynthesis of octanoate which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p KLLA0D02860g 0 240197 246019 ON 4 D02860 complement(240197..246019) similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Hypothetical ORF KLLA0D02882g 1 246326 246946 ON 4 D02882 (246326..246946) similar to uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid KLLA0D02904g 1 247177 247479 ON 4 D02904 (247177..247479) conserved hypothetical protein KLLA0D02926g 0 247616 248710 ON 4 D02926 complement(247616..248710) highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Third step in pyrimidine biosynthesis pathway dihydrooratase KLLA0D02948g 1 249292 251055 ON 4 D02948 (249292..251055) similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required along with Dph1p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p KLLA0D02970g 1 252052 253704 ON 4 D02970 (252052..253704) similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression KLLA0D02992g 0 253918 254445 ON 4 D02992 complement(253918..254445) highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Type 2B protein phosphatase regulatory B subunit of calcineurin KLLA0D03014g 0 254897 255658 ON 4 D03014 complement(254897..255658) some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 mediates cell type control of sporulation negatively regulates IME1 and sporulation zinc finger protein negative regulator of meiosis directly repressed by a1-a2 regulator KLLA0D03036g 0 255868 256974 ON 4 D03036 complement(255868..256974) similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Substituent of the Paf1 complex together with RNA polymerase II Paf1p Hpr1p Ctr9 Leo1 Rtf1 and Ccr4p distinct from Srb-containing Pol II complexes required for the expression of certain genes and modification of some histones KLLA0D03058g 1 257433 261638 ON 4 D03058 (257433..261638) similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Hypothetical ORF Klac_4.trna6L 0 261828 261911 ON 4 tL-UAA complement(261828..261911) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 70.04 Klac_4.trna7L 1 263097 263180 ON 4 tL-UAA (263097..263180) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 70.31 Klac_4.trna8L 0 263506 263589 ON 4 tL-UAA complement(263506..263589) tRNA Type: Leu (L) | Anti-Codon: UAA | Cove Score: 70.31 KLLA0D03146g 0 263816 264970 ON 4 D03146 complement(263816..264970) similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase) hydrolyzes the pyrophosphate linkage in NADH and related nucleotides localizes to peroxisomes KLLA0D03168g 1 265761 267278 ON 4 D03168 (265761..267278) similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking gene expression DNA repair and chromosome segregation binds the CTD of RNA pol II homolog of mammalian casein kinase 1delta (CK1delta) KLLA0D03190g 1 267933 269051 ON 4 D03190 (267933..269051) highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 Involved in nutrient control of cell growth and division cAMP-dependent protein kinase catalytic subunit KLLA0D03212g 0 269287 269799 ON 4 D03212 complement(269287..269799) similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid KLLA0D03234g 1 270311 270679 ON 4 D03234 (270311..270679) highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6 contacts DNA mutations affect transcription start site, KLLA0D03256g 0 271036 273507 ON 4 D03256 complement(271036..273507) similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W RCS1 Transcription factor involved in iron utilization and homeostasis binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability KLLA0D03278g 0 274580 275734 ON 4 D03278 complement(274580..275734) weakly similar to uniprot|Q08956 Saccharomyces cerevisiae YPL201C KLLA0D03322g 0 276591 278624 ON 4 D03322 complement(276591..278624) similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor activates multiple genes in response to hyperthermia recognizes variable heat shock elements KLLA0D03333g 1 279426 279578 ON 4 D03333 (279426..279578) no similarity KLLA0D03344g 1 279652 281364 ON 4 D03344 (279652..281364) similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase oxidizes D-lactate to pyruvate transcription is heme-dependent repressed by glucose and derepressed in ethanol or lactate located in the mitochondrial inner membrane KLLA0D03366g 1 281588 282556 ON 4 D03366 (281588..282556) weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB) required for insertion of the newly duplicated SPB into the nuclear envelope potentially phosphorylated by Cdc28p KLLA0D03388g 0 282705 283448 ON 4 D03388 complement(282705..283448) similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Hypothetical ORF KLLA0D03410g 1 284516 286345 ON 4 D03410 (284516..284526,285104..285197,285725..286345) highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C RPL7A and to uniprot|Q12213 Saccharomyces cerevisiae YPL198W RPL7B Proteins component of the large (60S) ribosomal subunit KLLA0D03432g 1 287805 292256 ON 4 D03432 (287805..292256) similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 ABC transporter KLLA0D03454g 1 293313 295226 ON 4 D03454 (293313..295226) similar to uniprot|P05316 YBR021W Saccharomyces cerevisiae FUR4 Uracil permease localized to the plasma membrane KLLA0D03476g 1 296287 300969 ON 4 D03476 (296287..300969) similar to uniprot|P33302 Saccharomyces cerevisiae YOR153W PDR5 Short-lived membrane ABC (ATP-binding cassette) transporter KLLA0D03498g 0 301249 304776 ON 4 D03498 complement(301249..304776) similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin required for synthesis of the majority of cell wall chitin the chitin ring during bud emergence and spore wall chitosan KLLA0D03520g 1 305905 307278 ON 4 D03520 (305905..307278) highly similar to uniprot|Q96W94 Saccharomyces kluyveri PYD3 Beta-alanine synthase KLLA0D03542g 0 307437 310193 ON 4 D03542 complement(307437..310193) similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II requires activation from zymogenic form in order to catalyze the transfer of N- acetylglucosamine (GlcNAc) to chitin required for the synthesis of chitin in the primary septum during cytokinesis Klac_4.trna9G 1 310699 310809 ON 4 tG-UCC (310699..310736,310775..310809) tRNA Type: Gly (G) | Anti-Codon: UCC | Cove Score: 67.15 KLLA0D03608g 1 311190 312371 ON 4 D03608 (311190..312371) highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C Hypothetical ORF KLLA0D03630g 0 312661 313599 ON 4 D03630 complement(312661..313599) similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C KLLA0D03652g 0 314243 315172 ON 4 D03652 complement(314243..315172) highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization KLLA0D03674g 0 315846 317207 ON 4 D03674 complement(315846..317207) similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus contains a PAM domain implicated in protein- protein binding KLLA0D03696g 1 317854 318312 ON 4 D03696 (317854..318312) highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase catalyzes the phosphorylation of nucleoside diphosphates into the corresponding triphosphates for nucleic acid biosynthesis KLLA0D03718g 1 318725 319957 ON 4 D03718 (318725..319957) weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway along with Nam7p and Nmd2p involved in decay of mRNA containing nonsense codons, KLLA0D03740g 1 320199 320531 ON 4 D03740 (320199..320531) no similarity KLLA0D03751g 0 320521 321084 ON 4 D03751 complement(320521..321084) conserved hypothetical protein KLLA0D03773g 1 321716 322141 ON 4 D03773 (321716..322141) similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Homolog of human core snRNP protein D1 involved in snRNA maturation U6 snRNP protein KLLA0D03795g 0 322289 322993 ON 4 D03795 complement(322289..322993) similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle dispensable for spliceosome assembly but required for conformational changes which lead to catalytic activation of the spliceosome KLLA0D03817g 0 323294 323767 ON 4 D03817 complement(323294..323767) similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit KLLA0D03839g 1 324274 325941 ON 4 D03839 (324274..325941) highly similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Cytoplasmic aspartyl-tRNA synthetase homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation KLLA0D03861g 1 326381 327973 ON 4 D03861 (326381..327973) similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0D03883g 1 328358 329833 ON 4 D03883 (328358..329833) weakly similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome contains a U-box a motif found in a class of ubiquitin ligases KLLA0D03905g 0 330128 330634 ON 4 D03905 complement(330128..330634) similar to uniprot|P38143 Saccharomyces cerevisiae YBR244W GPX2 Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress KLLA0D03927g 1 331864 332472 ON 4 D03927 (331864..332472) no similarity KLLA0D03949g 1 333566 334243 ON 4 D03949 (333566..334243) similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function contains an N- terminal epsin- like domain KLLA0D03971g 1 334691 334990 ON 4 D03971 (334691..334990) similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Cytochrome c oxidase assembly protein Klac_4.trna10L 1 335455 335585 ON 4 tL-UAG (335455..335491,335542..335585) tRNA Type: Leu (L) | Anti-Codon: UAG | Cove Score: 57.89 KLLA0D04037g 1 336499 337833 ON 4 D04037 (336499..337833) highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 O-acetyl homoserine-O-acetyl serine sulfhydrylase required for sulfur amino acid synthesis KLLA0D04059g 0 338422 343128 ON 4 D04059 complement(338422..343128) similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family found in vacuolar membrane involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates along with Ycf1p KLLA0D04092g 0 344666 348124 ON 4 D04092 complement(344666..348124) similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)- transporting ATPase KLLA0D04114g 0 348791 350278 ON 4 D04114 complement(348791..350278) similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM KLLA0D04136g 1 350976 352124 ON 4 D04136 (350976..352124) conserved hypothetical protein KLLA0D04158g 0 353145 354698 ON 4 D04158 complement(353145..354698) some similarities with uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N- terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association KLLA0D04181g 1 357299 357532 ON 4 D04181 (357299..357532) no similarity KLLA0D04202g 1 362270 363061 ON 4 D04202 (362270..363061) weakly similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C Hypothetical ORF KLLA0D04224g 1 363732 365654 ON 4 D04224 (363732..365654) highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 member of 70 kDa heat shock protein family Klac_4.trna11L 1 366089 366219 ON 4 tL-UAG (366089..366125,366176..366219) tRNA Type: Leu (L) | Anti-Codon: UAG | Cove Score: 57.25 Klac_YGOB_Anc_8.115 1 366536 367471 ON 4 Anc_8.115 (366536..367099,367103..367471) ANNOTATED BY YGOB - KLLA0D04334g 1 368361 368579 ON 4 D04334 (368361..368579) similar to gnl|GLV|CAGL0J01699g Candida glabrata CAGL0J01699g KLLA0D04356g 0 369403 371277 ON 4 D04356 complement(369403..371277) conserved hypothetical protein KLLA0D04378g 0 372640 373542 ON 4 D04378 complement(372640..373542) similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Hypothetical ORF KLLA0D04400g 1 374127 374483 ON 4 D04400 (374127..374483) highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Vacuolar H ATPase subunit F of the catalytic (V1) sector KLLA0D04422g 0 374631 376199 ON 4 D04422 complement(374631..376199) some similarities with uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Protein of unknown function involved in chitin biosynthesis by regulating Chs3p localization also involved in cell fusion during mating, KLLA0D04444g 1 377424 379379 ON 4 D04444 (377424..379379) highly similar to uniprot|Q00711 Saccharomyces cerevisiae YKL148C SDH1 Flavoprotein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone KLLA0D04466g 1 380305 381462 ON 4 D04466 (380305..381462) similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme involved in intron turnover required for efficient Ty1 transposition, KLLA0D04488g 0 381861 382751 ON 4 D04488 complement(381861..382751) similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase involved in ergosterol biosynthesis KLLA0D04510g 1 383229 384221 ON 4 D04510 (383229..384221) similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Hypothetical ORF KLLA0D04532g 0 384354 385445 ON 4 D04532 complement(384354..385445) similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34 interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex KLLA0D04554g 0 385733 388801 ON 4 D04554 complement(385733..388801) similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Shows homology to ATP-dependent permeases Active transport ATPase KLLA0D04576g 0 389302 390309 ON 4 D04576 complement(389302..390309) similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Hypothetical ORF KLLA0D04598g 1 390602 396766 ON 4 D04598 (390602..396766) similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase vacuolar membrane kinase that generates phosphatidylinositol (3 5)P2 which is involved in vacuolar sorting and homeostasis Klac_4.trna12S 0 396972 397066 ON 4 tS-GCU complement(396972..397016,397030..397066) tRNA Type: Ser (S) | Anti-Codon: GCU | Cove Score: 66.20 KLLA0D04664g 1 397818 399320 ON 4 D04664 (397818..399320) similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphatidylinositol 3 5-bisphosphate- binding protein of the vacuolar membrane predicted to fold as a seven-bladed beta-propeller required for recycling of Atg9p through the pre-autophagosomal structure KLLA0D04686g 0 399588 399950 ON 4 D04686 complement(399588..399950) no similarity KLLA0D04708g 1 400541 402895 ON 4 D04708 (400541..402895) similar to uniprot|Q759V0 Ashbya gossypii ADR172C ADR172Cp and weakly similar to YOR018W uniprot|Q02805 Saccharomyces cerevisiae YOR018W ROD1 Membrane protein overexpression confers resistance to the GST substrate o- dinitrobenzene as well as to zinc and calcium contains a PY-motif which is required for Rod1p interaction with Rsp5p a hect-type ubiquitin ligase Klac_4.trna13D 1 403068 403139 ON 4 tD-GUC (403068..403139) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 Klac_YGOB_VMA9 0 403479 403951 ON 4 VMA9 complement(403479..403611,403725..403805,403944..403951) ANNOTATED BY YGOB - KLLA0D04752g 1 404281 405737 ON 4 D04752 (404281..404340,404457..405737) similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome homologous to the mouse and human Tsg101 tumor susceptibility gene mutants exhibit a Class E Vps phenotype KLLA0D04774g 1 406024 408846 ON 4 D04774 (406024..408846) some similarities with uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene KLLA0D04796g 1 409305 410729 ON 4 D04796 (409305..410729) uniprot|O13473 Kluyveromyces lactis CBF5 Centromere/microtubule-binding protein CBF5 KLLA0D04818g 0 411615 412679 ON 4 D04818 complement(411615..412679) similar to gnl|GLV|CAGL0H03707g Candida glabrata CAGL0H03707g and some similarites with YNL007C uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 HSP40 family chaperone sit4 suppressor dnaJ homolog KLLA0D04840g 1 413362 414273 ON 4 D04840 (413362..414273) highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface component of the TOR signaling pathway associates with both Tor1p and Tor2p contains a WD-repeat KLLA0D04862g 0 414872 417331 ON 4 D04862 complement(414872..417331) some similarities with uniprot|P48743 Saccharomyces cerevisiae YLR176C KLLA0D04884g 1 419435 420391 ON 4 D04884 (419435..420391) similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C KLLA0D04906g 1 420903 421991 ON 4 D04906 (420903..421991) highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase catalyzes the third step in the leucine biosynthesis pathway KLLA0D04928g 0 422549 424042 ON 4 D04928 complement(422549..424042) highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S)biogenesis required for the post- transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs essential protein located predominantly in mitochondria KLLA0D04950g 1 424550 425374 ON 4 D04950 (424550..425374) similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane member of the mitochondrial carrier family required for biotin biosynthesis and respiratory growth KLLA0D04972g 0 425543 426661 ON 4 D04972 complement(425543..426661) similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C required for sister chromatid cohesion KLLA0D04994g 1 427195 431481 ON 4 D04994 (427195..431481) similar to uniprot|Q9HF61 Ashbya gossypii AAL016C BUD3 Bud site selection protein BUD3 and weakly similar to YCL014W uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding KLLA0D05016g 0 431592 433353 ON 4 D05016 complement(431592..432911,433342..433353) similar to uniprot|P38922 Saccharomyces cerevisiae YNL004W KLLA0D05038g 1 433653 435674 ON 4 D05038 (433653..435674) similar to uniprot|Q754A1 Ashbya gossypii AFR171W AFR171Wp and weakly similar to YDR034C uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer KLLA0D05060g 1 436335 437906 ON 4 D05060 (436335..437906) similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Pyridoxine transporter KLLA0D05082g 1 438653 439117 ON 4 D05082 (438653..439117) highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain N-terminal 25 residues of precursor are cleaved during mitochondrial import, KLLA0D05115g 1 440882 441241 ON 4 D05115 (440882..441241) highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C KLLA0D05137g 1 441827 443614 ON 4 D05137 (441827..443614) highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl- tRNA synthetase, forms a tetramer with Frs2p to generate the active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence,but substrate binding is similar and similar to gnl|GLV|YALI0E22979g KLLA0D05159g 0 443727 446465 ON 4 D05159 complement(443727..446465) similar to uniprot|Q75BQ1 Ashbya gossypii ACR220C ACR220Cp and weakly similar to YFL034W uniprot|P43564 Saccharomyces cerevisiae YFL034W Possible integral membrane protein that interacts with Rpp0p which is a component of the ribosomal stalk KLLA0D05181g 1 446903 447755 ON 4 D05181 (446903..446914,447399..447755) similar to uniprot|P05749 Saccharomyces cerevisiae YLR061W RPL22A Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein KLLA0D05203g 1 448206 449249 ON 4 D05203 (448206..449249) similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Hypothetical ORF KLLA0D05225g 1 449550 450470 ON 4 D05225 (449550..449572,449678..450470) similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Component of the RAM signaling network localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation Mob1p-like protein KLLA0D05247g 0 450769 454560 ON 4 D05247 complement(450769..454560) similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W KLLA0D05269g 0 455261 456610 ON 4 D05269 complement(455261..456610) highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin associates with alpha- tubulin (Tub1p and Tub3p) to form tubulin dimer which polymerizes to form microtubules KLLA0D05291g 1 457872 458738 ON 4 D05291 (457872..458738) similar to uniprot|Q12144 Saccharomyces cerevisiae YLR064W Hypothetical ORF KLLA0D05313g 1 459496 460110 ON 4 D05313 (459496..460110) highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Ras-like small GTPase involved in the ER-to-Golgi step of the secretory pathway complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) KLLA0D05335g 0 460426 460971 ON 4 D05335 complement(460426..460971) similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Hypothetical ORF KLLA0D05357g 1 461726 463633 ON 4 D05357 (461726..461735,462516..463633) highly similar to uniprot|P60010 Saccharomyces cerevisiae YFL039C ACT1 Actin structural protein involved in cell polarization endocytosis and other cytoskeletal functions KLLA0D05379g 0 464200 465690 ON 4 D05379 complement(464200..465690) weakly similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W KLLA0D05401g 1 466109 466678 ON 4 D05401 (466109..466678) similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p Spc2p Spc3p Sec11p) which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway homologous to mammalian SPC22/23 KLLA0D05423g 0 466943 469792 ON 4 D05423 complement(466943..469792) similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA also influences stability of intron-containing COX1 primary transcripts located in the mitochondrial inner membrane KLLA0D05445g 1 470419 470853 ON 4 D05445 (470419..470853) similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre- rRNA transcripts KLLA0D05467g 0 471053 473320 ON 4 D05467 complement(471053..473320) highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 mitochondrial elongation factor G- like protein KLLA0D05489g 0 473992 475845 ON 4 D05489 complement(473992..475845) similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W KLLA0D05511g 0 476363 477427 ON 4 D05511 complement(476363..477427) similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase expression is induced in the presence of sorbitol KLLA0D05533g 0 478454 481450 ON 4 D05533 complement(478454..481450) similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Component of RNA polymerase II holoenzyme/mediator complex affects chromatin structure and transcriptional regulation of diverse genes required for glucose repression HO repression RME1 repression and sporulation KLLA0D05555g 1 482279 484453 ON 4 D05555 (482279..484453) weakly similar to uniprot|P43560 Saccharomyces cerevisiae YFL042C Due to a sequence change (deletion of G at 46151) YFL043C is now part of YFL042C KLLA0D05577g 0 484697 485266 ON 4 D05577 complement(484697..485266) similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C Hypothetical ORF KLLA0D05599g 1 485753 486712 ON 4 D05599 (485753..486712) similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C YOD1 Yeast OTU Deubiquitinating enzyme 1 KLLA0D05621g 0 486879 487382 ON 4 D05621 complement(486879..487382) similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0D05643g 1 488021 488683 ON 4 D05643 (488021..488683) highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W KLLA0D05709g 1 492707 493471 ON 4 D05709 (492707..493471) highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 involved in synthesis of GDP- mannose and dolichol-phosphate-mannose required for protein assembly in endoplasmic reticulum phosphomannomutase KLLA0D05731g 0 493687 494325 ON 4 D05731 complement(493687..494325) highly similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 The authentic non-tagged protein was localized to the mitochondria KLLA0D05753g 1 494751 496592 ON 4 D05753 (494751..496592) similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 The authentic non-tagged protein was localized to the mitochondria KLLA0D05775g 0 496779 497640 ON 4 D05775 complement(496779..497522,497638..497640) similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor) localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi KLLA0D05797g 1 498347 499150 ON 4 D05797 (498347..499150) similar to uniprot|Q75CY2 Ashbya gossypii ABR240W ABR240Wp and weakly similar to YLR079W uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 P40 inhibitor of Cdc28p-Clb5p protein kinase complex KLLA0D05819g 0 499409 501472 ON 4 D05819 complement(499409..501472) similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p KLLA0D05841g 1 501740 502138 ON 4 D05841 (501740..502138) conserved hypothetical protein KLLA0D05863g 1 502506 503819 ON 4 D05863 (502506..503819) similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport KLLA0D05885g 0 503910 505442 ON 4 D05885 complement(503910..505442) similar to uniprot|Q75CX8 Ashbya gossypii ABR244C ABR244Cp and weakly similar to YFL049W uniprot|P43554 Saccharomyces cerevisiae YFL049W Hypothetical ORF KLLA0D05907g 0 505826 506707 ON 4 D05907 complement(505826..506707) similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Hypothetical ORF KLLA0D05929g 1 507555 508784 ON 4 D05929 (507555..508784) highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A) required for the posttranslational precursor maturation of vacuolar proteinases synthesized as a zymogen self-activates KLLA0D05951g 1 509713 511719 ON 4 D05951 (509713..511719) similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning KLLA0D05973g 1 512611 513456 ON 4 D05973 (512611..513456) some similarities with uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein predicted to have 1 transmembrane segment transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift KLLA0D05995g 0 513734 514645 ON 4 D05995 complement(513734..514645) similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 TrimethylGuanosine Synthase KLLA0D06017g 1 516038 517816 ON 4 D06017 (516038..517816) weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C Hypothetical ORF KLLA0D06039g 0 518035 519357 ON 4 D06039 complement(518035..519357) similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Hypothetical ORF KLLA0D06061g 1 520082 520831 ON 4 D06061 (520082..520831) weakly similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Protein required for respiratory growth and stability of the mitochondrial genome KLLA0D06083g 0 521215 521565 ON 4 D06083 complement(521215..521565) conserved hypothetical protein KLLA0D06105g 0 522480 525767 ON 4 D06105 complement(522480..525767) highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase ligates leucine to the appropriate tRNA KLLA0D06127g 0 526164 527156 ON 4 D06127 complement(526164..527156) similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases KLLA0D06149g 1 527705 528754 ON 4 D06149 (527705..528754) similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C likely functions in pathway(s) outside Ras KLLA0D06171g 0 528904 531318 ON 4 D06171 complement(528904..531318) similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia may be involved in regulation of intracellular adenine nucleotide pools KLLA0D06193g 0 531646 532026 ON 4 D06193 complement(531646..532026) conserved hypothetical protein KLLA0D06215g 1 532434 533144 ON 4 D06215 (532434..533144) similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Hypothetical ORF KLLA0D06237g 0 533640 535472 ON 4 D06237 complement(533640..535472) similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) KLLA0D06259g 0 536532 538877 ON 4 D06259 complement(536532..538877) similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K /H antiporter KLLA0D06281g 1 540031 542289 ON 4 D06281 (540031..542289) conserved hypothetical protein KLLA0D06303g 1 542884 543486 ON 4 D06303 (542884..543486) similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W Klac_4.trna14L 0 543828 543943 ON 4 tL-CAA complement(543828..543871,543906..543943) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.66 KLLA0D06380g 0 544437 545738 ON 4 D06380 complement(544437..545738) similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W ZSP1 KLLA0D06402g 1 547385 549280 ON 4 D06402 (547385..549280) weakly similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating localizes to the ER membrane exhibits genetic interactions with KAR2 KLLA0D06424g 0 549532 551109 ON 4 D06424 complement(549532..551109) similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y processed to mature form by Prb1p KLLA0D06446g 0 551644 555915 ON 4 D06446 complement(551644..555915) conserved hypothetical protein KLLA0D06479g 0 556926 557447 ON 4 D06479 complement(556926..557447) no similarity KLLA0D06501g 0 558598 559203 ON 4 D06501 complement(558598..559203) similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery, KLLA0D06523g 1 559526 561184 ON 4 D06523 (559526..561184) similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N- acetyltransferase) mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine forms a complex with Arg5 6p Klac_4.trna15C 1 561671 561742 ON 4 tC-GCA (561671..561742) tRNA Type: Cys (C) | Anti-Codon: GCA | Cove Score: 75.04 KLLA0D06567g 1 562063 563340 ON 4 D06567 (562063..563340) similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 RNAse member of the T(2) family of endoribonucleases, KLLA0D06589g 0 563451 564272 ON 4 D06589 complement(563451..564272) some similarities with uniprot|P33419 Saccharomyces cerevisiae YPL124W SPC29 Inner plaque spindle pole body (SPB) component KLLA0D06611g 1 565742 568453 ON 4 D06611 (565742..568453) similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing dephosporylates Hog1p MAPK and regulates its localization localized to the nucleus KLLA0D06633g 0 568539 571610 ON 4 D06633 complement(568539..571610) similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin with a role in the assembly or export of 60S ribosomal subunits KLLA0D06655g 0 572219 573502 ON 4 D06655 complement(572219..573502) highly similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase KLLA0D06677g 0 574289 576844 ON 4 D06677 complement(574289..576844) similar to uniprot|Q02931 YPL126W Saccharomyces cerevisiae NAN1 U3 snoRNP protein component of the small (ribosomal) subunit (SSU) processosome containing U3, KLLA0D06699g 1 577334 577546 ON 4 D06699 (577334..577546) highly similar to uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta common to RNA polymerases I II and III KLLA0D06721g 0 578072 580723 ON 4 D06721 complement(578072..580723) similar to uniprot|P32266 YOR211C Saccharomyces cerevisiae MGM1 Mitochondrial GTPase related to dynamin present in a complex containing Ugo1p and Fzo1p KLLA0D06765g 1 583615 585036 ON 4 D06765 (583615..585036) weakly similar to uniprot|Q02457 YPL128C Saccharomyces cerevisiae TBF1 TTAGGG repeat binding factor KLLA0D06787g 1 586289 587599 ON 4 D06787 (586289..587599) similar to uniprot|P18851 YOR212W Saccharomyces cerevisiae STE4 G protein beta subunit KLLA0D06809g 0 587709 588275 ON 4 D06809 complement(587709..588275) similar to uniprot|Q75C19 Ashbya gossypii ACR098C ACR098Cp and some similarites with YPL129W uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit (30 kDa) of TFIID TFIIF and SWI/SNF complexes involved in RNA polymerase II transcription initiation and in chromatin modification contains a YEATS domain KLLA0D06831g 0 588834 589712 ON 4 D06831 complement(588834..589595,589704..589712) similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W TAF14 Subunit(30 kDa) of TFIID, TFIIF, and SWI/SNF complexes,involved in RNA polymerase II transcription initiation and in chromatin modification, contains a YEATS domain KLLA0D06853g 0 590221 590778 ON 4 D06853 complement(590221..590778) similar to uniprot|Q12032 YOR215C Saccharomyces cerevisiae Hypothetical ORF KLLA0D06875g 0 591141 592529 ON 4 D06875 complement(591141..592529) similar to uniprot|Q12234 YOR216C Saccharomyces cerevisiae RUD3 Golgi matrix protein that is involved in the structural organization of the cis-Golgi KLLA0D06897g 1 592913 595420 ON 4 D06897 (592913..595420) similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C) which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon KLLA0D06919g 0 595450 598068 ON 4 D06919 complement(595450..598068) similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences required for maturation of alpha factor transcription is induced by a-factor KLLA0D06941g 0 598560 599453 ON 4 D06941 complement(598560..599453) highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 component of the large (60S) ribosomal subunit KLLA0D06963g 1 599738 600223 ON 4 D06963 (599738..600223) no similarity KLLA0D06985g 1 600527 601303 ON 4 D06985 (600527..601303) similar to gnl|GLV|CAGL0J04158g Candida glabrata CAGL0J04158g and weakly similar to YOR220W uniprot|Q12044 Saccharomyces cerevisiae YOR220W Hypothetical ORF KLLA0D07007g 0 601656 602441 ON 4 D07007 complement(601656..602441) similar to uniprot|P19516 YPL132W Saccharomyces cerevisiae COX11 Mitochondrial membrane protein required for assembly of active cytochrome c oxidase KLLA0D07029g 1 602763 604367 ON 4 D07029 (602763..604367) similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Regulator of drug sensitivity Transcriptional regulator KLLA0D07051g 0 604505 605476 ON 4 D07051 complement(604505..605476) similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling KLLA0D07073g 1 606857 607750 ON 4 D07073 (606857..607750) similar to uniprot|Q03028 Saccharomyces cerevisiae YPL134C ODC1 Mitochondrial inner membrane transporter exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism KLLA0D07095g 1 608975 609715 ON 4 D07095 (608975..609715) similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Hypothetical ORF KLLA0D07117g 0 609913 610569 ON 4 D07117 complement(609913..610569) conserved hypothetical protein KLLA0D07139g 0 611102 611539 ON 4 D07139 complement(611102..611539) highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5 common to RNA polymerases I II and III KLLA0D07161g 0 612348 612890 ON 4 D07161 complement(612348..612890) similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W ISU1 Conserved protein of the mitochondrial matrix KLLA0D07216g 1 614450 618286 ON 4 D07216 (614450..618286) similar to uniprot|Q12276 Saccharomyces cerevisiae YOR227W Hypothetical ORF KLLA0D07238g 0 618435 619286 ON 4 D07238 complement(618435..619286) similar to uniprot|Q12106 Saccharomyces cerevisiae Hypothetical ORF KLLA0D07260g 1 619630 620658 ON 4 D07260 (619630..620658) similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C SPP1 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres KLLA0D07282g 1 621115 622467 ON 4 D07282 (621115..622467) similar to gnl|GLV|CAGL0M02563g Candida glabrata CAGL0M02563g and weakly similar to uniprot|Q12206 YOR229W Saccharomyces cerevisiae WTM2 WD repeat containing transcriptional modulator 2 KLLA0D07304g 1 623352 624749 ON 4 D07304 (623352..624749) some similarities with uniprot|P32490 Saccharomyces cerevisiae YOR231W MKK1 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity upon activation by Bck1p phosphorylates downstream target Slt2p functionally redundant with Mkk2p KLLA0D07326g 1 625107 625838 ON 4 D07326 (625107..625838) similar to uniprot|P38523 YOR232W Saccharomyces cerevisiae MGE1 Protein of the mitochondrial matrix involved in protein import into mitochondria KLLA0D07348g 1 626999 629728 ON 4 D07348 (626999..629728) similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C Hypothetical ORF KLLA0D07370g 0 630095 631894 ON 4 D07370 complement(630095..631894) similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF KLLA0D07405g 0 633063 634027 ON 4 D07405 complement(633063..633367,634009..634027) highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W RPL33A Ribosomal Protein of the Large subunit KLLA0D07414g 0 635851 637941 ON 4 D07414 complement(635851..637941) similar to uniprot|Q75BZ7 Ashbya gossypii ACR122C ACR122Cp and some similarities with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins KLLA0D07436g 0 639179 639625 ON 4 D07436 complement(639179..639625) weakly similar to uniprot|Q6Q5F7 Saccharomyces cerevisiae YPL144W Hypothetical ORF KLLA0D07458g 1 639883 640581 ON 4 D07458 (639883..640581) similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase part of the dTTP biosynthetic pathway involved in folate metabolism possibly required for mitochondrial function KLLA0D07480g 1 641278 642525 ON 4 D07480 (641278..642525) similar to uniprot|P35844 YPL145C Saccharomyces cerevisiae KES1 Member of the oxysterol binding protein family which includes seven yeast homologs involved in negative regulation of Sec14p-dependent Golgi complex secretory functions KLLA0D07502g 0 642751 646482 ON 4 D07502 complement(642751..646482) similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex essential protein involved in chromosome segregation and in double-strand DNA break repair SMC chromosomal ATPase family member binds DNA with a preference for DNA with secondary structure KLLA0D07524g 0 647018 647425 ON 4 D07524 complement(647018..647425) conserved hypothetical protein KLLA0D07546g 0 647984 649927 ON 4 D07546 complement(647984..649927) similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition associates with Skp1p and Cdc53p to form a complex SCFCdc4 which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p KLLA0D07568g 1 650626 651738 ON 4 D07568 (650626..651738) conserved hypothetical protein KLLA0D07579g 1 651918 652211 ON 4 D07579 (651918..652211) highly similar to uniprot|Q6D0Z1 Erwinia carotovora subsp ECA3657 Putative exported protein KLLA0D07590g 1 652790 654859 ON 4 D07590 (652790..654859) similar to uniprot|Q750H9 Ashbya gossypii AGL028C AGL028Cp and weakly similar to YFL013C uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex KLLA0D07612g 0 654909 655721 ON 4 D07612 complement(654909..655721) conserved hypothetical protein KLLA0D07634g 0 656256 656576 ON 4 D07634 complement(656256..656576) similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane localized protein that protects membranes from desiccation induced by heat shock oxidative stress osmostress stationary phase entry glucose depletion oleate and alcohol regulated by the HOG and Ras- Pka pathways KLLA0D07656g 1 658179 659594 ON 4 D07656 (658179..659594) similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix localizes to the mitochondrial inner membrane member of the DnaJ family of molecular chaperones KLLA0D07678g 1 660137 660436 ON 4 D07678 (660137..660160,660239..660436) highly similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2 KLLA0D07700g 0 660561 661127 ON 4 D07700 complement(660561..661127) similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6- phosphate acetyltransferase required for multiple cell cycle events including passage through START DNA synthesis and mitosis involved in UDP-N-acetylglucosamine synthesis forms GlcNAc6P from AcCoA KLLA0D07722g 0 661143 661655 ON 4 D07722 complement(661143..661655) weakly similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Hypothetical ORF KLLA0D07744g 0 662166 663647 ON 4 D07744 complement(662166..663647) similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4 ) expression is under the nitrogen catabolite repression regulation KLLA0D07766g 0 664947 666416 ON 4 D07766 complement(664947..666416) similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4 ) expression is under the nitrogen catabolite repression regulation KLLA0D07788g 1 667841 668506 ON 4 D07788 (667841..668506) similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Hypothetical ORF KLLA0D07810g 0 669095 671251 ON 4 D07810 complement(669095..671251) some similarities with uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Protein kinase involved in cell wall biosynthesis required for efficient apical growth proper mating projection morphology bipolar bud site selection in diploid cells and cell separation KLLA0D07832g 0 671772 672682 ON 4 D07832 complement(671772..672088,672679..672682) highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C RPL42B Proteins component of the large (60S) ribosomal subunit KLLA0D07854g 1 673829 674782 ON 4 D07854 (673829..674782) similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7 KLLA0D07876g 0 674961 675176 ON 4 D07876 complement(674961..675176) similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A KLLA0D07898g 1 675451 678831 ON 4 D07898 (675451..678831) similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C RIA1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) KLLA0D07920g 1 679160 680167 ON 4 D07920 (679160..680167) weakly similar to uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway interacts with Bfa1p and functions upstream of Bub2p and Bfa1p KLLA0D07942g 1 681139 681933 ON 4 D07942 (681139..681933) some similarities with uniprot|P38844 Sacharromyces cerevisiae YHR143W KLLA0D07964g 0 682226 683278 ON 4 D07964 complement(682226..683278) weakly similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Hypothetical ORF KLLA0D07986g 1 683732 684730 ON 4 D07986 (683732..684730) similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck may interact directly with the Cdc11p septin localizes to bud neck in a septin-dependent manner KLLA0D08008g 1 684998 685210 ON 4 D08008 (684998..685210) highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10- alpha common to RNA polymerases I II and III KLLA0D08030g 1 685876 687540 ON 4 D08030 (685876..687540) weakly similar to uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 KLLA0D08052g 1 687922 688707 ON 4 D08052 (687922..688707) highly similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 The authentic non-tagged protein was localized to mitochondria KLLA0D08074g 0 688785 689807 ON 4 D08074 complement(688785..689807) similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deaminase required for dCTP and dTTP synthesis expression is cell cycle regulated KLLA0D08096g 1 690272 691750 ON 4 D08096 (690272..691750) similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane converts phosphatidylserine to phosphatidylethanolamine KLLA0D08118g 0 691907 696760 ON 4 D08118 complement(691907..696760) similar to uniprot|Q754Q1 Ashbya gossypii AFR021W AFR021Wp and weakly similar to YNL172W uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition Klac_4.trna16P 0 697048 697169 ON 4 tP-UGG complement(697048..697083,697134..697169) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 59.72 KLLA0D08184g 1 698125 699495 ON 4 D08184 (698125..699495) weakly similar to uniprot|P38845 Saccharomyces cerevisiae YHR146W CRP1 Protein that binds to cruciform DNA structures KLLA0D08206g 1 700152 701327 ON 4 D08206 (700152..701327) similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C NOP13 Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA KLLA0D08239g 1 701887 703053 ON 4 D08239 (701887..703053) conserved hypothetical protein KLLA0D08261g 1 703455 704354 ON 4 D08261 (703455..704354) similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit KLLA0D08283g 0 704597 705205 ON 4 D08283 complement(704597..705205) similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface, KLLA0D08305g 0 705625 706338 ON 4 D08305 complement(705625..706338) highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit KLLA0D08327g 1 708240 709004 ON 4 D08327 (708240..709004) similar to gnl|GLV|DEHA0F04004g Debaryomyces hansenii DEHA0F04004g and weakly similar to YNL180C uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non- essential small GTPase of the Rho/Rac subfamily of Ras- like proteins likely involved in protein kinase C (Pkc1p)- dependent signal transduction pathway that controls cell integrity KLLA0D08349g 0 709391 710608 ON 4 D08349 complement(709391..710608) similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Protein required for cell viability KLLA0D08371g 1 710885 712411 ON 4 D08371 (710885..712411) similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Protein required for cell viability computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunit KLLA0D08393g 1 712747 713409 ON 4 D08393 (712747..713409) some similarities with uniprot|Q07623 Saccharomyces cerevisiae YDL213C KLLA0D08415g 1 714473 716797 ON 4 D08415 (714473..716797) similar to uniprot|P22211 Saccharomyces cerevisiae YNL183C NPR1 Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation KLLA0D08437g 1 717270 717719 ON 4 D08437 (717270..717719) similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit KLLA0D08459g 0 718046 720298 ON 4 D08459 complement(718046..720298) some similarities with uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties may regulate silencing by acting on Sir4p involved in posttranscriptionally regulating Gap1p and possibly other transporters primarily located in the nucleus KLLA0D08481g 1 722139 725237 ON 4 D08481 (722139..725237) similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD( )-dependent glutamate dehydrogenase degrades glutamate to ammonia and alpha-ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels KLLA0D08503g 1 725605 726726 ON 4 D08503 (725605..726726) some similarities with uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 subunit of COP9 signalosome (CSN) COP9 signalosome KLLA0D08514g 0 726710 727945 ON 4 D08514 complement(726710..727945) similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W Non-essential protein with putative leucine-rich nuclear export signal (NES) sequence that fits the consensus sequence recognized by Crm1p KLLA0D08536g 1 728219 728809 ON 4 D08536 (728219..728809) highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family KLLA0D08558g 0 728936 729700 ON 4 D08558 complement(728936..729700) conserved hypothetical protein KLLA0D08580g 0 730189 731805 ON 4 D08580 complement(730189..731805) highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 karyopherin alpha homolog of 60 kDa KLLA0D08624g 0 733382 733897 ON 4 D08624 complement(733382..733897) some similarities with uniprot|P53872 Saccharomyces cerevisiae YNL190W Hypothetical ORF KLLA0D08646g 0 734915 735775 ON 4 D08646 complement(734915..735775) weakly similar to uniprot|Q7LGR3 Saccharomyces cerevisiae YDL218W KLLA0D08668g 0 737071 738165 ON 4 D08668 complement(737071..738165) similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W Hypothetical ORF KLLA0D08690g 0 738466 738918 ON 4 D08690 complement(738466..738918) highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase functions in protein translation may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes KLLA0D08712g 0 739348 741447 ON 4 D08712 complement(739348..741447) similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase involved in ergosterol biosynthesis associated and coordinately regulated with Erg11p KLLA0D08734g 0 742009 742932 ON 4 D08734 complement(742009..742932) similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential protein of unknown function , Klac_4.trna17Q 0 743262 743333 ON 4 tQ-UUG complement(743262..743333) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 69.31 KLLA0D08789g 0 743690 744019 ON 4 D08789 complement(743690..744019) no similarity KLLA0D08811g 0 744046 744615 ON 4 D08811 complement(744046..744615) similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Hypothetical ORF KLLA0D08833g 0 745179 745304 ON 4 D08833 complement(745179..745304) conserved hypothetical protein Klac_4.trna18Q 1 745312 745383 ON 4 tQ-UUG (745312..745383) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 69.31 KLLA0D08866g 1 745975 747300 ON 4 D08866 (745975..747300) similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase) joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway KLLA0D08888g 0 747666 750551 ON 4 D08888 complement(747666..750551) similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Protein required for cell viability KLLA0D08910g 1 750828 751448 ON 4 D08910 (750828..751448) similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1 KLLA0D08932g 1 751943 752779 ON 4 D08932 (751943..752779) similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2 involved in the identification of the start codon KLLA0D08954g 0 753196 753723 ON 4 D08954 complement(753196..753723) similar to uniprot|Q755G7 Ashbya gossypii AFL144C AFL144Cp and weakly similar to YMR184W uniprot|Q03233 Saccharomyces cerevisiae YMR184W Hypothetical ORF KLLA0D08976g 1 755870 756586 ON 4 D08976 (755870..756586) conserved hypothetical protein KLLA0D08998g 0 756649 758505 ON 4 D08998 complement(756649..758505) weakly similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly KLLA0D09020g 1 758818 760410 ON 4 D09020 (758818..760410) similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) contains the signal sequence- binding activity of SRP interacts with the SRP RNA and mediates binding of SRP to signal receptor contains GTPase domain KLLA0D09042g 1 760795 761832 ON 4 D09042 (760795..761832) some similarities with uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud also required for cortical ER inheritance KLLA0D09064g 1 762314 763231 ON 4 D09064 (762314..763231) similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function overproduction blocks cell cycle arrest in the presence of mating pheromone KLLA0D09086g 1 763408 764607 ON 4 D09086 (763408..764607) weakly similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C Protein required for cell viability, KLLA0D09108g 0 764634 765998 ON 4 D09108 complement(764634..765998) similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Hypothetical ORF KLLA0D09130g 1 766400 767323 ON 4 D09130 (766400..767323) some similarities with uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p Vps15p and Vps30p) required for organization of a pre- autophagosomal structure ATG14 transcription is activated by Gln3p during nitrogen starvation KLLA0D09152g 1 767715 769268 ON 4 D09152 (767715..769268) highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Vacuolar H ATPase regulatory subunit KLLA0D09174g 0 769519 771084 ON 4 D09174 complement(769519..771084) similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial Distribution and Morphology KLLA0D09196g 1 772795 773673 ON 4 D09196 (772795..773673) similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme or E2 together with Skp1p Rbx1p Cdc53p and an F-box protein forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation KLLA0D09218g 0 774788 775198 ON 4 D09218 complement(774788..775198) no similarity KLLA0D09240g 0 775848 778094 ON 4 D09240 complement(775848..778094) weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C GAC1 Regulatory subunit for Glc7p (protein phosphatase I) for glycogen synthesis regulatory role also predicted for glucose repression and ion homeostasis potential Cdc28p substrate KLLA0D09262g 1 780273 782513 ON 4 D09262 (780273..782513) similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W CDC46 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase KLLA0D09284g 1 782856 783188 ON 4 D09284 (782856..783188) highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 U1 snRNP protein of the Sm class KLLA0D09306g 1 783852 788465 ON 4 D09306 (783852..788465) similar to uniprot|P04821 Saccharomyces cerevisiae YLR310C CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor) indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP required for progression through G1 KLLA0D09328g 0 788565 791705 ON 4 D09328 complement(788565..791705) similar to uniprot|P38990 Saccharomyces cerevisiae YER129W PAK1 Upstream kinase for the SNF1 complex partially redundant function with Elm1p and Tos3p members of this family of kinases have functional orthology with LKB1 a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome KLLA0D09350g 0 792405 794096 ON 4 D09350 complement(792405..794096) highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo Klac_4.trna19M 1 794667 794739 ON 4 tM-CAU (794667..794739) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 KLLA0D09394g 1 795025 797436 ON 4 D09394 (795025..797436) similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Required for Vacuolar Protein Sorting Vps53p is a hydrophilic protein that is peripherally associated with the late Golgi and forms a stable complex with Vps52p and Vps54p. KLLA0D09416g 1 797743 798336 ON 4 D09416 (797743..798336) no similarity KLLA0D09438g 0 798454 799044 ON 4 D09438 complement(798454..799044) highly similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex which delays the onset of anaphase in cells with defects in mitotic spindle assembly forms a complex with Mad1p KLLA0D09460g 1 799233 800305 ON 4 D09460 (799233..799235,799325..800305) highly similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p KLLA0D09482g 0 800338 801309 ON 4 D09482 complement(800338..801309) similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C KLLA0D09504g 0 801783 804095 ON 4 D09504 complement(801783..804095) highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis KLLA0D09526g 1 804422 805075 ON 4 D09526 (804422..805075) similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C Hypothetical ORF KLLA0D09559g 0 805863 807614 ON 4 D09559 complement(805863..807614) similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p KLLA0D09581g 1 809203 810870 ON 4 D09581 (809203..810870) similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter KLLA0D09603g 1 811234 813696 ON 4 D09603 (811234..813696) weakly similar to uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function required for survival upon exposure to K1 killer toxin, KLLA0D09625g 0 813773 814510 ON 4 D09625 complement(813773..814510) highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 superkiller ExtraCellular Mutant Ribosomal RNA Processing homolog of RNAse PH KLLA0D09647g 0 814829 816037 ON 4 D09647 complement(814829..816037) similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1 4 mannosyltransferase I involved in GPI anchor biosynthesis requires Pbn1p for function homolog of mammalian PIG-M, KLLA0D09669g 1 816343 816750 ON 4 D09669 (816343..816750) conserved hypothetical protein KLLA0D09691g 1 817452 818999 ON 4 D09691 (817452..818999) weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Hypothetical ORF KLLA0D09713g 0 819182 819817 ON 4 D09713 complement(819182..819817) no similarity KLLA0D09735g 1 820211 822199 ON 4 D09735 (820211..822199) similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport also binds to chromatin to promote the association of DNA replication factors and replication initiation KLLA0D09757g 0 822299 824125 ON 4 D09757 complement(822299..824125) similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W MPP10 Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p KLLA0D09779g 0 824518 826404 ON 4 D09779 complement(824518..826404) similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter imports large neutral amino acids into the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters KLLA0D09801g 1 827563 830193 ON 4 D09801 (827563..830193) similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Hypothetical ORF Klac_4.trna20S 0 830546 830627 ON 4 tS-AGA complement(830546..830627) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 Klac_4.trna21S 0 831051 831132 ON 4 tS-AGA complement(831051..831132) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 KLLA0D09867g 0 831834 834218 ON 4 D09867 complement(831834..834218) similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C SMP2 Protein involved in respiration and plasmid maintenance KLLA0D09889g 0 834904 835998 ON 4 D09889 complement(834904..835998) similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C Hypothetical ORF KLLA0D09911g 1 836851 838023 ON 4 D09911 (836851..838023) similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C KLLA0D09933g 0 838199 839356 ON 4 D09933 complement(838199..839356) similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex KLLA0D09955g 1 839640 841814 ON 4 D09955 (839640..841814) similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis postmeiotic segregation and spore viability forms a complex with Pms1p and Msh2p to repair mismatched DNA human homolog is associated with hereditary non-polyposis colon cancer KLLA0D09977g 0 841852 843756 ON 4 D09977 complement(841852..843756) similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein component of the CBF3 complex that binds the CDEIII region of the centromere contains an N-terminal Zn2Cys6 type zinc finger domain a C-terminal acidic domain and a putative coiled coil dimerization domain KLLA0D09999g 0 844368 845873 ON 4 D09999 complement(844368..845873) highly similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytosolic aldehyde dehydrogenase that uses NAD as the preferred coenzyme expression is induced in response to high osmotic stress KLLA0D10021g 1 847239 848750 ON 4 D10021 (847239..848750) similar to uniprot|P47771 Saccharomyces cerevisiae YMR170c ALD5 and to uniprot|P54114 Saccharomyces cerevisiae YMR169c ALD4 KLLA0D10043g 1 849549 851015 ON 4 D10043 (849549..851015) similar to uniprot|Q755L6 Ashbya gossypii AFL202C AFL202Cp and weakly similar to YDL106C uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor regulatory targets include genes involved in phosphate metabolism binds cooperatively with Pho4p to the PHO5 promoter phosphorylation of Pho2p facilitates interaction with Pho4p KLLA0D10065g 0 851283 852683 ON 4 D10065 complement(851283..852683) similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C Endosomal protein of unknown function mRNA is targeted to the bud via the mRNA transport system involving She2p KLLA0D10109g 1 854495 855424 ON 4 D10109 (854495..855424) similar to uniprot|P14065 Saccharomyces cerevisiae YOR120W GCY1 Putative NADP( ) coupled glycerol dehydrogenase proposed to be involved in an alternative pathway for glycerol catabolism KLLA0D10131g 0 855951 857342 ON 4 D10131 complement(855951..857342) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0D10153g 1 858016 859983 ON 4 D10153 (858016..859983) some similarities with uniprot|P35995 Saccharomyces cerevisiae YKL222C Hypothetical ORF KLLA0D10175g 1 861073 861525 ON 4 D10175 (861073..861525) conserved hypothetical protein KLLA0D10197g 0 861726 864296 ON 4 D10197 complement(861726..864296) similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type involved in the regulation of arginine-responsive genes acts with Arg80p and Arg82p KLLA0D10219g 1 864863 865342 ON 4 D10219 (864863..865342) similar to uniprot|P11747 Saccharomyces cerevisiae YML098W KLLA0D10241g 0 865680 867365 ON 4 D10241 complement(865680..867365) similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Glycoprotein required for oxidative protein folding in the endoplasmic reticulum KLLA0D10263g 0 868131 869444 ON 4 D10263 complement(868131..869444) similar to uniprot|P54787 Saccharomyces cerevisiae YML097C KLLA0D10285g 1 869754 871301 ON 4 D10285 (869754..871301) similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Hypothetical ORF KLLA0D10307g 0 871349 872050 ON 4 D10307 complement(871349..872050) similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p) cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) homolog of human XPF protein KLLA0D10329g 1 872320 872896 ON 4 D10329 (872320..872335,872448..872896) highly similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it KLLA0D10351g 1 873366 875945 ON 4 D10351 (873366..875945) similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0D10373g 0 876175 876927 ON 4 D10373 complement(876175..876927) highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 20S proteasome beta-type subunit, KLLA0D10395g 1 877463 878282 ON 4 D10395 (877463..877468,877605..878282) conserved hypothetical protein KLLA0D10417g 0 878575 878769 ON 4 D10417 complement(878575..878769) similar to uniprot|P39103 Saccharomyces cerevisiae YML129C COX14 Mitochondrial membrane protein, required for assembly of cytochrome c oxidase KLLA0D10439g 0 879449 880906 ON 4 D10439 complement(879449..880906) similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum msc1 mutants are defective in directing meiotic recombination events to homologous chromatids KLLA0D10461g 1 882149 883843 ON 4 D10461 (882149..883843) similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway KLLA0D10483g 0 884177 887839 ON 4 D10483 complement(884177..887839) similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein component of mitochondrial RNase P along with the mitochondrially-encoded RNA subunit RPM1 Rnase P removes 5' extensions from tRNA precursors Rpm2p is also involved in maturation of RPM1 and in translation of mitochondrial mRNAs KLLA0D10505g 0 889601 891515 ON 4 D10505 complement(889601..890893,891414..891515) highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis KLLA0D10527g 1 892955 894892 ON 4 D10527 (892955..894892) similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 CDC28/cdc2 related protein kinase KLLA0D10549g 1 896011 898158 ON 4 D10549 (896011..898158) similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 Protein involved in desensitization to alpha- factor pheromone member of the RGS (regulator of G-protein signalling) family GTPase-activating protein KLLA0D10571g 0 898296 899858 ON 4 D10571 complement(898296..899858) highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2 involved in the identification of the start codon binds GTP when forming the ternary complex with GTP and tRNAi-Met KLLA0D10593g 0 900326 903103 ON 4 D10593 complement(900326..903103) similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation positively regulated by alpha-isopropylmalate an intermediate in leucine biosynthesis KLLA0D10615g 1 903967 905322 ON 4 D10615 (903967..905322) similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Hypothetical ORF KLLA0D10637g 0 905660 908257 ON 4 D10637 complement(905660..908257) similar to uniprot|P40017 YER024W Saccharomyces cerevisiae YAT2 Carnitine acetyltransferase KLLA0D10659g 0 909562 910245 ON 4 D10659 complement(909562..910245) highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W KLLA0D10681g 0 911076 912464 ON 4 D10681 complement(911076..912464) similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W CAF17 Mitochondrial protein that interacts with Ccr4p in the two-hybrid system 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins KLLA0D10703g 0 913356 914873 ON 4 D10703 complement(913356..914873) highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis KLLA0D10736g 0 915650 916507 ON 4 D10736 complement(915650..916507) highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase catalyzes the last step in proline biosynthesis, KLLA0D10758g 1 917125 919677 ON 4 D10758 (917125..919677) similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C Hypothetical ORF KLLA0D10780g 1 920068 920595 ON 4 D10780 (920068..920595) similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function KLLA0D10802g 0 920627 922642 ON 4 D10802 complement(920627..922642) similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 subunit of RNA polymerase II holoenzyme/mediator complex KLLA0D10824g 0 922978 924498 ON 4 D10824 complement(922978..924498) similar to uniprot|P40016 Saccharomyces cerevisiae YER021W KLLA0D10846g 0 925012 926382 ON 4 D10846 complement(925012..926382) highly similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing contains multiple transmembrane spans KLLA0D10868g 0 926978 927829 ON 4 D10868 complement(926978..927829) similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W Hypothetical ORF KLLA0D10890g 1 928435 929733 ON 4 D10890 (928435..929733) similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 adenosine kinase KLLA0D10912g 1 930173 932089 ON 4 D10912 (930173..932089) similar to uniprot|Q75D63 Ashbya gossypii ABR160C ABR160Cp and weakly similar to YJR106W uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Non-essential protein of unknown function KLLA0D10934g 1 932344 933474 ON 4 D10934 (932344..933474) similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Hypothetical ORF KLLA0D10956g 0 934074 935738 ON 4 D10956 complement(934074..935738) uniprot|P54111 Kluyveromyces lactis GPA2 Guanine nucleotide-binding protein alpha-2 subunit KLLA0D10978g 1 936863 937675 ON 4 D10978 (936863..937675) similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Hypothetical ORF KLLA0D11000g 1 938541 939620 ON 4 D11000 (938541..939620) similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C NADPH- dependent Oxidoreductases KLLA0D11022g 1 940600 941679 ON 4 D11022 (940600..941679) similar to uniprot|P53183 Saccharomyces cerevisiae YGL039W and similar to uniprot|P53111 Saccharomyces cerevisiae YGL157W and similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W and similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C NADPH- dependent Oxidoreductases KLLA0D11044g 0 942458 944068 ON 4 D11044 complement(942458..944068) some similarities with uniprot|P23292 Saccharomyces cerevisiae YNL154C YCK2 membrane-bound casein kinase I homolog KLLA0D11066g 0 945075 945875 ON 4 D11066 complement(945075..945875) conserved hypothetical protein KLLA0D11088g 1 947523 947894 ON 4 D11088 (947523..947894) no similarity KLLA0D11110g 1 948248 949840 ON 4 D11110 (948248..949840) similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase catalyzes the first step of tryptophan phenylalanine and tyrosine catabolism KLLA0D11132g 1 950190 950579 ON 4 D11132 (950190..950579) highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it, KLLA0D11143g 0 950719 951097 ON 4 D11143 complement(950719..950963,951052..951097) conserved hypothetical protein KLLA0D11154g 1 952049 953530 ON 4 D11154 (952049..953530) highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C LPD1 Dihydrolipoamide dehydrogenase the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi- enzyme complexes Klac_4.trna22A 0 953908 953980 ON 4 tA-AGC complement(953908..953980) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0D11198g 0 954239 955786 ON 4 D11198 complement(954239..955786) similar to uniprot|Q75DH5 Ashbya gossypii ABR051C ABR051Cp and weakly similar to YMR013C uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Membrane protein that catalyzes the CTP-mediated phosphorylation of dolichol the terminal step in dolichyl monophosphate (Dol- P) biosynthesis required for viability normal rates of lipid intermediate synthesis and protein N-glycosylation, KLLA0D11220g 1 958249 959682 ON 4 D11220 (958249..959682) similar to gnl|GLV|CAGL0M07678g Candida glabrata CAGL0M07678g and weakly similar to YMR014W uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern, KLLA0D11242g 0 959973 961577 ON 4 D11242 complement(959973..961577) highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs KLLA0D11264g 0 962069 964108 ON 4 D11264 complement(962069..964108) some similarities with uniprot|Q03213 Saccharomyces cerevisiae YMR172W KLLA0D11286g 0 964642 966678 ON 4 D11286 complement(964642..966678) conserved hypothetical protein KLLA0D11308g 0 967169 968806 ON 4 D11308 complement(967169..968806) similar to uniprot|O94493 Schizosaccharomyces pombe SPCC417 SPCC417.12 protein KLLA0D11330g 1 970243 971808 ON 4 D11330 (970243..971808) similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoin permease ureidosuccinate permease expression is constitutive but sensitive to nitrogen catabolite repression KLLA0D11352g 1 973371 974828 ON 4 D11352 (973371..974828) highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W HXK2 Hexokinase isoenzyme 2 catalyzes phosphorylation of glucose in the cytosol predominate hexokinase during growth on glucose functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene KLLA0D11374g 0 975206 976003 ON 4 D11374 complement(975206..976003) similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid synthetically lethal with RPT1 which is an ATPase component of the 19S regulatory particle physically interacts with Nob1p and Rpn3p KLLA0D11396g 0 976408 978018 ON 4 D11396 complement(976408..978018) similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER KLLA0D11418g 0 978322 980349 ON 4 D11418 complement(978322..980349) weakly similar to uniprot|P53061 Saccharomyces cerevisiae YGL249W ZIP2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis involved in meiotic recombination and disjunction KLLA0D11440g 0 980535 981428 ON 4 D11440 complement(980535..981428) similar to uniprot|P53060 Saccharomyces cerevisiae YGL250W Hypothetical ORF KLLA0D11462g 1 982040 985303 ON 4 D11462 (982040..985303) similar to uniprot|P51979 Saccharomyces cerevisiae YGL251C HFM1 Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control catalyzes the unwinding of Holliday junctions has ssDNA and dsDNA stimulated ATPase activity KLLA0D11484g 1 985655 987418 ON 4 D11484 (985655..987418) highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction regulates the subcellular location of Rtg1p and Rtg3p transcriptional activators of the retrograde (RTG) and TOR pathways Rtg2p is inhibited by the phosphorylated form of Mks1p KLLA0D11506g 1 987844 988641 ON 4 D11506 (987844..988641) highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 20S proteasome beta-type subunit, KLLA0D11528g 1 989252 990358 ON 4 D11528 (989252..990358) similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase controls glucose and intracellular acidification-induced cAMP signaling target of the cAMP-protein kinase A (PKA) pathway glucose induces transcription and inhibits translation KLLA0D11550g 0 990698 991099 ON 4 D11550 complement(990698..991099) similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W YMR31 Mitochondrial ribosomal protein of the small subunit KLLA0D11572g 0 991747 992865 ON 4 D11572 complement(991747..992865) conserved hypothetical protein KLLA0D11594g 1 993485 994144 ON 4 D11594 (993485..994144) similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Translational cofactor elongation factor-1 gamma participates in the regulation of GTP-binding protein EF-1 alpha may play a redundant role in the regulation of protein synthesis or another GTP-dependent process KLLA0D11638g 1 995087 996262 ON 4 D11638 (995087..996262) conserved hypothetical protein KLLA0D11660g 1 996785 998320 ON 4 D11660 (996785..998320) highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation KLLA0D11682g 1 998670 998963 ON 4 D11682 (998670..998963) similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 11kDa subunit of the SAGA histone acetyltransferase complex involved in regulation of transcription of a subset of SAGA-regulated genes KLLA0D11704g 1 999198 1000388 ON 4 D11704 (999198..1000388) similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Cytosolic protein required for sporulation also required for the ubiquitination of the gluconeogenetic enzyme fructose-1 6-bisphosphatase which is degraded rapidly after the switch from gluconeogenesis to glycolysis KLLA0D11726g 0 1000442 1000732 ON 4 D11726 complement(1000442..1000732) similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C forms heterodimer with Ela1p that participates in transcription elongation expression dramatically upregulated during sporulation widely conserved among eukaryotes KLLA0D11748g 1 1000988 1003369 ON 4 D11748 (1000988..1003369) similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Vacuolar sorting protein KLLA0D11770g 0 1003388 1004617 ON 4 D11770 complement(1003388..1004617) weakly similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein KLLA0D11792g 1 1005079 1007136 ON 4 D11792 (1005079..1007136) similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis contains four RNA recognition motifs (RRMs), KLLA0D11814g 0 1007240 1009021 ON 4 D11814 complement(1007240..1009021) uniprot|Q70W23 Kluyveromyces lactis srb10 Cyclin- dependent protein kinase KLLA0D11836g 0 1009428 1010030 ON 4 D11836 complement(1009428..1010030) some similarities with uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Hypothetical ORF KLLA0D11858g 0 1010259 1013231 ON 4 D11858 complement(1010259..1013231) similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase null mutant is deficient in respiratory growth KLLA0D11880g 1 1013755 1014711 ON 4 D11880 (1013755..1014711) some similarities with uniprot|Q03080 Saccharomyces cerevisiae YPL039W Hypothetical ORF KLLA0D11902g 1 1015273 1016142 ON 4 D11902 (1015273..1016142) some similarities with uniprot|Q12041 Saccharomyces cerevisiae YDR253C MET32 and some similarities with uniprot|Q03081 Saccharomyces cerevisiae YPL038W MET31 Zinc- finger DNA-binding proteins KLLA0D11924g 0 1016451 1016927 ON 4 D11924 complement(1016451..1016927) similar to uniprot|Q02642 Saccharomyces cerevisiae YPL037C EGD1 Subunit beta1 of the nascent polypeptide- associated complex (NAC) involved in protein targeting associated with cytoplasmic ribosomes enhances DNA binding of the Gal4p activator homolog of human BTF3b KLLA0D11946g 0 1017503 1020235 ON 4 D11946 complement(1017503..1020235) some similarities with Saccharomyces cerevisiae YPL032C SVL3 Protein of unknown function mutant phenotype suggests a potential role in vacuolar function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck and with YDR251W uniprot|P37304 Saccharomyces cerevisiae YDR251W PAM1 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype KLLA0D11968g 1 1021670 1022782 ON 4 D11968 (1021670..1022782) weakly similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Hypothetical ORF KLLA0D11990g 0 1022895 1023944 ON 4 D11990 complement(1022895..1023792,1023928..1023944) highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase with ten cyclin partners involved in environmental stress response in phosphate-rich conditions Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 KLLA0D12012g 1 1024590 1026203 ON 4 D12012 (1024590..1026203) similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W Hypothetical ORF KLLA0D12034g 1 1026586 1028841 ON 4 D12034 (1026586..1028841) similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase component of the mitochondrial degradosome KLLA0D12056g 1 1029222 1030418 ON 4 D12056 (1029222..1030418) highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another forming acetoacetyl-CoA involved in the first step in mevalonate biosynthesis KLLA0D12078g 1 1030847 1031392 ON 4 D12078 (1030847..1031392) similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Hypothetical ORF KLLA0D12100g 0 1031728 1033161 ON 4 D12100 complement(1031728..1033161) similar to uniprot|Q12505 Saccharomyces cerevisiae YPL026C SKS1 multicopy suppressor of snf3 and grr1 mutants serine/threonine protein kinase homologous to Ran1p, KLLA0D12122g 0 1033231 1033581 ON 4 D12122 complement(1033231..1033581) no similarity KLLA0D12144g 0 1034038 1034610 ON 4 D12144 complement(1034038..1034610) similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic KLLA0D12166g 1 1034883 1035578 ON 4 D12166 (1034883..1035578) similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Protein of unknown function GFP tagged protein localizes to the cytoplasm and nucleus KLLA0D12188g 0 1035588 1037537 ON 4 D12188 complement(1035588..1037537) similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10- methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway KLLA0D12210g 1 1037870 1041040 ON 4 D12210 (1037870..1041040) similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease KLLA0D12232g 0 1041135 1044527 ON 4 D12232 complement(1041135..1044527) some similarities with uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Global transcription activator that acts in complex with Snf2p Snf5p Snf6p and Swi3p to assist gene-specific activators involved in the regulation of expression of many genes including ADH1 ADH2 GAL1 HO INO1 and SUC2 Zinc-finger transcription factor KLLA0D12254g 1 1045077 1046618 ON 4 D12254 (1045077..1046618) highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W SIK1 Component of the small (ribosomal) subunit (SSU) processosome that contains U3 snoRNA KLLA0D12276g 0 1046970 1047824 ON 4 D12276 complement(1046970..1047737,1047816..1047824) similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C Hypothetical ORF KLLA0D12298g 1 1048089 1048436 ON 4 D12298 (1048089..1048436) similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Yeast nuclear gene KLLA0D12320g 0 1048556 1049308 ON 4 D12320 complement(1048556..1049308) similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C FMP53, KLLA0D12342g 1 1050181 1051335 ON 4 D12342 (1050181..1051335) highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) KLLA0D12364g 0 1051765 1053660 ON 4 D12364 complement(1051765..1053660) some similarities with uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1 KLLA0D12386g 0 1054141 1054776 ON 4 D12386 complement(1054141..1054776) similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential nuclear protein involved in the oxidative stress response KLLA0D12408g 1 1055117 1055671 ON 4 D12408 (1055117..1055671) similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation basal transcription factor KLLA0D12430g 0 1055878 1057134 ON 4 D12430 complement(1055878..1057134) similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Protein required for the maturation and translation of COX1 mRNA involved in maturation of COX1 and COB mRNA KLLA0D12452g 1 1057600 1057944 ON 4 D12452 (1057600..1057944) some similarities with uniprot|P32344 Saccharomyces cerevisiae YLR204W QRI5 KLLA0D12474g 0 1058158 1059096 ON 4 D12474 complement(1058158..1059096) similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized, heme-binding peroxidase involved in the degradation of heme KLLA0D12496g 0 1059684 1061786 ON 4 D12496 complement(1059684..1061786) similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair base excision repair and recombination, KLLA0D12518g 0 1062521 1063192 ON 4 D12518 complement(1062521..1063192) conserved hypothetical protein KLLA0D12540g 0 1063576 1064293 ON 4 D12540 complement(1063576..1063862,1064278..1064293) highly similar to uniprot|P05745 Saccharomyces cerevisiae YMR194W RPL36A and to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A RPL36B Proteins component of the large (60S) ribosomal subunit KLLA0D12562g 0 1064961 1065728 ON 4 D12562 complement(1064961..1065728) highly similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit KLLA0D12584g 0 1066032 1068155 ON 4 D12584 complement(1066032..1068155) some similarities with uniprot|Q12344 Saccharomyces cerevisiae YPL249C GYP5 GTPase-activating protein (GAP) for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p involved in ER to Golgi trafficking interacts with the yeast amphiphysins Rvs161p and Rvs167p KLLA0D12606g 0 1068516 1070297 ON 4 D12606 complement(1068516..1070297) weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative ion transporter similar to the major facilitator superfamily of transporters; mutations in membrane-spanning domains permit nonselective cation uptake KLLA0D12628g 1 1071637 1073373 ON 4 D12628 (1071637..1073373) weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase KLLA0D12650g 0 1073580 1075535 ON 4 D12650 complement(1073580..1075535) conserved hypothetical protein KLLA0D12672g 0 1076011 1078608 ON 4 D12672 complement(1076011..1078608) uniprot|P08657 Kluyveromyces lactis LAC9 Lactose regulatory protein LAC9 KLLA0D12694g 1 1079740 1083843 ON 4 D12694 (1079740..1083843) similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family, involved in maintenance of genome integrity KLLA0D12716g 0 1084062 1085849 ON 4 D12716 complement(1084062..1085849) similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease member of the allantoate transporter subfamily of the major facilitator superfamily mutation confers resistance to ethionine sulfoxide KLLA0D12738g 0 1086914 1090000 ON 4 D12738 complement(1086914..1090000) highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex required for the catabolism of glycine to 5 10-methylene-THF expression is regulated by levels of levels of 5 10-methylene-THF in the cytoplasm KLLA0D12760g 0 1090428 1091909 ON 4 D12760 complement(1090428..1091909) weakly similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Hypothetical ORF KLLA0D12782g 1 1092471 1093169 ON 4 D12782 (1092471..1093169) similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit KLLA0D12804g 0 1093369 1094184 ON 4 D12804 complement(1093369..1094184) similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p KLLA0D12826g 1 1094918 1096234 ON 4 D12826 (1094918..1096234) similar to uniprot|Q12179 Saccharomyces cerevisiae YPL245W Hypothetical ORF KLLA0D12848g 0 1096275 1097294 ON 4 D12848 complement(1096275..1097294) similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen KLLA0D12870g 1 1097784 1099538 ON 4 D12870 (1097784..1099538) similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane KLLA0D12892g 1 1099951 1101315 ON 4 D12892 (1099951..1101315) weakly similar to uniprot|Q03236 Saccharomyces cerevisiae YMR187C Hypothetical ORF KLLA0D12914g 0 1101471 1105955 ON 4 D12914 complement(1101471..1105955) similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern promotes localization of axial markers Bud4p and Cdc12p KLLA0D12936g 0 1106301 1107245 ON 4 D12936 complement(1106301..1107070,1107164..1107245) weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 Tubulin folding factor C (putative) involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl KLLA0D12958g 0 1107587 1109728 ON 4 D12958 complement(1107587..1109728) highly similar to uniprot|P15108 Saccharomyces cerevisiae YMR186W HSC82 Cytoplasmic chaperone of the Hsp90 family KLLA0D12980g 1 1110164 1111357 ON 4 D12980 (1110164..1111357) highly similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase involved in asparagine catabolism KLLA0D13002g 1 1111951 1112985 ON 4 D13002 (1111951..1112985) conserved hypothetical protein KLLA0D13024g 1 1113372 1115516 ON 4 D13024 (1113372..1115516) highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD( ) synthetase essential for the formation of NAD( ) from nicotinic acid adenine dinucleotide KLLA0D13046g 0 1115641 1116828 ON 4 D13046 complement(1115641..1116828) similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit also identified as a small subunit mitochondrial ribosomal protein KLLA0D13068g 0 1117229 1119862 ON 4 D13068 complement(1117229..1119862) weakly similar to uniprot|P32454 Saccharomyces cerevisiae YKL157W APE2 Zinc-dependent metallopeptidase yscII and to YHR047C uniprot|P37898 Saccharomyces cerevisiae YHR047C AAP1' Arginine/alanine aminopeptidase KLLA0D13079g 0 1120154 1120420 ON 4 D13079 complement(1120154..1120420) no similarity KLLA0D13090g 1 1120945 1122036 ON 4 D13090 (1120945..1122036) similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit, KLLA0D13112g 0 1122669 1122959 ON 4 D13112 complement(1122669..1122959) similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase which is a large evolutionarily conserved enzyme complex required for ATP synthesis essential for the dimeric state of ATP synthase KLLA0D13134g 1 1123794 1124843 ON 4 D13134 (1123794..1124843) similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Mitochondrially localized type 2C protein phosphatase expression induced by growth on ethanol and by sustained osmotic stress possible role in carbon source utilization in low oxygen environments KLLA0D13156g 0 1124902 1128272 ON 4 D13156 complement(1124902..1128183,1128267..1128272) similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway interacts with Nam7p and Upf3p KLLA0D13178g 0 1128555 1130129 ON 4 D13178 complement(1128555..1130129) similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high- fidelity vesicle docking and fusion which are essential for targeting of vesicles to the endosome required for vacuole inheritance KLLA0D13200g 1 1130332 1131984 ON 4 D13200 (1130332..1131984) similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W Hypothetical ORF KLLA0D13222g 0 1132067 1134277 ON 4 D13222 complement(1132067..1134277) similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0D13244g 1 1134517 1137693 ON 4 D13244 (1134517..1137693) similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Yeast Condensin G KLLA0D13266g 0 1137750 1141208 ON 4 D13266 complement(1137750..1141208) similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease transmembrane protein that initiates the unfolded protein response signal by regulating synthesis of Hac1p through HAC1 mRNA splicing KLLA0D13288g 1 1141866 1142561 ON 4 D13288 (1141866..1142561) no similarity KLLA0D13310g 0 1143027 1144730 ON 4 D13310 complement(1143027..1144730) uniprot|P18631 Kluyveromyces lactis RAG1 Low- affinity glucose transporter KLLA0D13332g 0 1146434 1147645 ON 4 D13332 complement(1146434..1147645) similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways required for the diauxic growth shift expression in mammalian cells increases survival under conditions inducing apoptosis KLLA0D13354g 1 1148444 1150567 ON 4 D13354 (1148444..1150567) weakly similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition structurally and functionally related to Pif1p KLLA0D13376g 1 1150858 1152849 ON 4 D13376 (1150858..1152849) similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1 3-mannosyltransferase adds the fourth and fifth alpha-1 3-linked mannose residues to O-linked glycans during protein O-glycosylation KLLA0D13398g 1 1153371 1157345 ON 4 D13398 (1153371..1157345) some similarities with uniprot|P32521 YIR006C Saccharomyces cerevisiae PAN1 Part of actin cytoskeleton- regulatory complex Pan1p-Sla1p-End3p KLLA0D13420g 0 1157491 1157991 ON 4 D13420 complement(1157491..1157991) similar to uniprot|P40565 YIR005W Saccharomyces cerevisiae IST3 Component of the U2 snRNP required for the first catalytic step of splicing and for spliceosomal assembly KLLA0D13442g 1 1158327 1159034 ON 4 D13442 (1158327..1159034) similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Hypothetical ORF KLLA0D13464g 0 1159251 1160552 ON 4 D13464 complement(1159251..1160552) similar to uniprot|P40564 YIR004W Saccharomyces cerevisiae DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import KLLA0D13486g 0 1160938 1162749 ON 4 D13486 complement(1160938..1162749) some similarities with uniprot|P40563 Saccharomyces cerevisiae YIR003W Hypothetical ORF, KLLA0D13508g 0 1162973 1163350 ON 4 D13508 complement(1162973..1163350) highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport KLLA0D13530g 1 1163768 1167478 ON 4 D13530 (1163768..1167478) some similarities with uniprot|P33332 YER008C Saccharomyces cerevisiae SEC3 Non-essential subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p Exo84p) KLLA0D13552g 1 1167629 1170655 ON 4 D13552 (1167629..1170655) similar to uniprot|P40562 YIR002C Saccharomyces cerevisiae MPH1 Member of the DEAH family of helicases, KLLA0D13574g 1 1171410 1172070 ON 4 D13574 (1171410..1171420,1171536..1172070) similar to uniprot|P89886 YER007C-A Saccharomyces cerevisiae TMA20 Protein of unknown function that associates with ribosomes KLLA0D13596g 0 1172223 1173701 ON 4 D13596 complement(1172223..1173701) similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation binds alpha-tubulin required for normal microtubule function null mutant exhibits cold- sensitive microtubules and sensitivity to benomyl KLLA0D13618g 0 1174077 1175669 ON 4 D13618 complement(1174077..1175669) similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre- ribosomes required for export of 60S ribosomal subunits from the nucleus KLLA0D13640g 1 1176601 1177674 ON 4 D13640 (1176601..1177674) uniprot|Q05959 Kluyveromyces lactis KLLA0D13640g SUA7 Transcription initiation factor IIB KLLA0D13662g 0 1178179 1180143 ON 4 D13662 complement(1178179..1180143) similar to uniprot|P40009 YER005W Saccharomyces cerevisiae YND1 Yeast Nucleoside Diphosphatase KLLA0D13684g 0 1180483 1181157 ON 4 D13684 complement(1180483..1181157) similar to uniprot|P40008 Saccharomyces cerevisiae YER004W FMP52 The authentic non-tagged protein was localized to the mitochondria KLLA0D13706g 0 1181451 1182107 ON 4 D13706 complement(1181451..1182107) conserved hypothetical protein KLLA0D13728g 1 1182559 1183845 ON 4 D13728 (1182559..1183845) highly similar to uniprot|P29952 YER003C Saccharomyces cerevisiae PMI40 mannose-6-phosphate isomerase KLLA0D13750g 0 1184048 1184767 ON 4 D13750 complement(1184048..1184767) similar to uniprot|P40007 YER002W Saccharomyces cerevisiae NOP16 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis, KLLA0D13772g 1 1185663 1186700 ON 4 D13772 (1185663..1186700) some similarities with uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein contains an RNA recognition motif (RRM) may have a role in mRNA translation as suggested by genetic interactions with genes encoding proteins involved in translational initiation Klac_CEN4 1 1187303 1187500 ON 4 CEN4 (1187303..1187500) Chromosome IV centromere KLLA0D13816g 1 1188279 1188995 ON 4 D13816 (1188279..1188995) similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C Hypothetical ORF KLLA0D13838g 0 1189057 1190595 ON 4 D13838 complement(1189057..1190595) similar to uniprot|P40560 YIL001W Saccharomyces cerevisiae Hypothetical ORF KLLA0D13860g 1 1190927 1193752 ON 4 D13860 (1190927..1193752) similar to uniprot|P40559 YIL002C Saccharomyces cerevisiae INP51 Phosphatidylinositol 4 5-bisphosphate 5- phosphatase KLLA0D13871g 0 1193813 1194040 ON 4 D13871 complement(1193813..1194040) conserved hypothetical protein KLLA0D13882g 1 1194407 1195705 ON 4 D13882 (1194407..1195705) similar to uniprot|P33767 YEL002C Saccharomyces cerevisiae WBP1 wheat germ agglutinin-binding protein oligosaccharyl transferase glycoprotein complex beta subunit KLLA0D13904g 0 1195920 1196350 ON 4 D13904 complement(1195920..1196236,1196332..1196350) similar to uniprot|P40005 YEL003w Saccharomyces cerevisiae GIM4 subunit of the heterohexameric cochaperone prefoldin complex KLLA0D13926g 0 1196673 1197686 ON 4 D13926 complement(1196673..1197686) similar to uniprot|P40004 Saccharomyces cerevisiae YEL004W KLLA0D13948g 1 1198201 1199046 ON 4 D13948 (1198201..1199046) weakly similar to uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function KLLA0D13970g 0 1199071 1199922 ON 4 D13970 complement(1199071..1199922) similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved putative P-loop ATPase localized in the cytoplasm has a potential role in assembly of iron-sulfur clusters in proteins KLLA0D13992g 1 1200329 1200772 ON 4 D13992 (1200329..1200772) similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C KLLA0D14014g 0 1200970 1203090 ON 4 D14014 complement(1200970..1203090) similar to uniprot|P40557 YIL005W Saccharomyces cerevisiae EPS1 protein disulfide isomerase related protein involved in endoplasmic reticulum retention of resident ER proteins KLLA0D14036g 0 1203522 1204817 ON 4 D14036 complement(1203522..1204817) similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W Pvruvate transporter of the mitochondrial inner membrane member of the mitochondrial carrier family has putative mouse and human orthologs KLLA0D14058g 0 1205424 1206932 ON 4 D14058 complement(1205424..1206932) some similarities with uniprot|P40002 Saccharomyces cerevisiae YEL007W Hypothetical ORF and some similarities with YHR177W uniprot|P38867 Saccharomyces cerevisiae YHR177W, KLLA0D14113g 1 1209913 1210914 ON 4 D14113 (1209913..1210914) similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels KLLA0D14135g 1 1211322 1212077 ON 4 D14135 (1211322..1212077) weakly similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C NAS2 Protein with similarity to the p27 subunit of mammalian proteasome modulator not essential interacts with Rpn4p KLLA0D14157g 0 1212133 1212438 ON 4 D14157 complement(1212133..1212438) highly similar to uniprot|P40554 YIL008W Saccharomyces cerevisiae URM1 Ubiquitin-like protein with only weak sequence similarity to ubiquitin Klac_4.trna23R 1 1212660 1212731 ON 4 tR-UCU (1212660..1212731) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 KLLA0D14201g 1 1213327 1215078 ON 4 D14201 (1213327..1215078) similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2- isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway Klac_4.trna24W 1 1215339 1215447 ON 4 tW-CCA (1215339..1215374,1215412..1215447) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 66.54 Klac_4.trna25D 1 1215538 1215609 ON 4 tD-GUC (1215538..1215609) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 KLLA0D14289g 1 1215729 1216283 ON 4 D14289 (1215729..1216283) similar to uniprot|Q03096 Saccharomyces cerevisiae YIL009C-A EST3 Component of the telomerase holoenzyme involved in telomere replication KLLA0D14311g 1 1216574 1217905 ON 4 D14311 (1216574..1217905) similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 medium subunit of the clathrin-associated protein complex KLLA0D14333g 0 1218148 1218765 ON 4 D14333 complement(1218148..1218765) similar to uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase KLLA0D14355g 0 1219658 1221424 ON 4 D14355 complement(1219658..1221424) similar to uniprot|Q08977 YPL260W Saccharomyces cerevisiae Hypothetical ORF KLLA0D14377g 0 1221875 1223158 ON 4 D14377 complement(1221875..1223158) some similarities with uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Protein involved in cell wall integrity and stress response KLLA0D14399g 1 1224490 1226067 ON 4 D14399 (1224490..1226067) some similarities with uniprot|P40574 Saccharomyces cerevisiae YIR018W YAP5 bZIP transcription factor KLLA0D14421g 0 1226243 1227655 ON 4 D14421 complement(1226243..1227655) similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall Klac_4.trna26T 0 1228117 1228189 ON 4 tT-AGU complement(1228117..1228189) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 Klac_4.trna27M 1 1228695 1228766 ON 4 tM-CAU (1228695..1228766) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.04 KLLA0D14487g 1 1229115 1229645 ON 4 D14487 (1229115..1229645) similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Predicted acireductone dioxygenease of the methionine salvage pathway KLLA0D14509g 1 1230053 1231135 ON 4 D14509 (1230053..1231135) similar to uniprot|Q03687 YMR010W Saccharomyces cerevisiae Protein of unknown function KLLA0D14531g 0 1231373 1233487 ON 4 D14531 complement(1231373..1233487) similar to uniprot|P32606 YOR017W Saccharomyces cerevisiae PET127 Protein with a role in mitochondrial RNA stability and/or processing KLLA0D14553g 1 1234322 1235584 ON 4 D14553 (1234322..1235584) similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C FMP12 The authentic non-tagged protein was localized to the mitochondria KLLA0D14575g 1 1235601 1236806 ON 4 D14575 (1235601..1236806) weakly similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction required for homologous chromosome pairing and synaptonemal complex formation, Klac_4.trna28P 0 1236874 1236995 ON 4 tP-UGG complement(1236874..1236909,1236960..1236995) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 60.36 KLLA0D14641g 1 1237252 1237878 ON 4 D14641 (1237252..1237878) similar to uniprot|P39704 Saccharomyces cerevisiae YAL007C ERP2 Protein that forms a heterotrimeric complex with Erp1p Emp24p and Erv25p member along with Emp24p and Erv25p of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles KLLA0D14663g 1 1238190 1239416 ON 4 D14663 (1238190..1239416) similar to uniprot|Q06103 Saccharomyces cerevisiae YPR108W KLLA0D14685g 1 1240247 1241899 ON 4 D14685 (1240247..1241899) similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T has a role in protection from oxidative damage by hydrogen peroxide KLLA0D14707g 1 1242483 1245125 ON 4 D14707 (1242483..1245125) similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p which is a subunit of RNA polymerases I II and III computational analysis of large- scale protein-protein interaction data suggests a role in chromosome segregation KLLA0D14762g 0 1246745 1247149 ON 4 D14762 complement(1246745..1247149) no similarity Klac_4.trna29T 1 1247371 1247442 ON 4 tT-UGU (1247371..1247442) tRNA Type: Thr (T) | Anti-Codon: UGU | Cove Score: 79.33 KLLA0D14806g 1 1247991 1251629 ON 4 D14806 (1247991..1251629) similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data KLLA0D14828g 1 1251991 1252524 ON 4 D14828 (1251991..1252524) conserved hypothetical protein KLLA0D14861g 0 1253023 1254027 ON 4 D14861 complement(1253023..1254027) highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit common to RNA polymerase I and III KLLA0D14883g 1 1254381 1255784 ON 4 D14883 (1254381..1255784) weakly similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor component of the U4/U6-U5 snRNP complex KLLA0D14905g 1 1256065 1257768 ON 4 D14905 (1256065..1257768) similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W DBF2 Ser/Thr kinase involved in transcription and stress response functions as part of a network of genes in exit from mitosis localization is cell cycle regulated activated by Cdc15p during the exit from mitosis KLLA0D14927g 1 1258177 1259700 ON 4 D14927 (1258177..1259700) similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Hypothetical ORF KLLA0D14949g 0 1259860 1262496 ON 4 D14949 complement(1259860..1262496) similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites shows partial nucleolar localization contains five consensus RNA-binding domains, KLLA0D14971g 1 1263323 1266598 ON 4 D14971 (1263323..1266598) highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 mitochondrial and cytoplasmic valyl-tRNA synthetase KLLA0D14993g 0 1266752 1267429 ON 4 D14993 complement(1266752..1267429) similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Ribosomal RNA Processing Putative 3'->5' exoribonuclease component of exosome complex of 3'->5' exonucleases KLLA0D15015g 1 1267803 1268756 ON 4 D15015 (1267803..1268756) similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Tpc1p is a transporter that catalyzes the uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria it is located in the mitochondrial membrane and its expression appears to be regulated by carbon source KLLA0D15037g 1 1269125 1269802 ON 4 D15037 (1269125..1269802) similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase required for biosynthesis of phosphatidylinositol which is a precursor for polyphosphoinositides sphingolipids and glycolipid anchors for some of the plasma membrane proteins KLLA0D15059g 1 1270160 1271146 ON 4 D15059 (1270160..1271146) similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Hypothetical ORF KLLA0D15081g 1 1271696 1274728 ON 4 D15081 (1271696..1274728) some similarities with Saccharomyces cerevisiae YPR115W Hypothetical ORF and to YGR097W uniprot|P48361 Saccharomyces cerevisiae YGR097W ASK10 Component of the RNA polymerase II holoenzyme phosphorylated in response to oxidative stress has a role in destruction of Ssn8p which relieves repression of stress-response genes KLLA0D15103g 0 1275080 1275745 ON 4 D15103 complement(1275080..1275745) conserved hypothetical protein KLLA0D15125g 1 1275978 1276826 ON 4 D15125 (1275978..1276826) weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W Hypothetical ORF KLLA0D15136g 0 1276819 1281594 ON 4 D15136 complement(1276819..1281594) similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin inhibited by Pds1p KLLA0D15158g 1 1281895 1283895 ON 4 D15158 (1281895..1283895) similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats required for telomere length regulation and telomere position effect, KLLA0D15180g 1 1284273 1291412 ON 4 D15180 (1284273..1291412) weakly similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Hypothetical ORF KLLA0D15202g 1 1291872 1294706 ON 4 D15202 (1291872..1294706) similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p Ypt31p and Sec4p involved in recycling of internalized proteins and regulation of Golgi secretory function KLLA0D15224g 1 1294983 1296014 ON 4 D15224 (1294983..1296014) similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology belongs to the rhomboid-GlpG superfamily of intramembrane peptidases KLLA0D15246g 0 1296105 1296629 ON 4 D15246 complement(1296105..1296629) similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Hypothetical ORF KLLA0D15268g 1 1297155 1298972 ON 4 D15268 (1297155..1298972) similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis constituent of several different pre-ribosomal particles KLLA0D15290g 0 1299227 1299994 ON 4 D15290 complement(1299227..1299994) similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 subunit of RNA polymerase II holoenzyme/mediator complex KLLA0D15312g 1 1300224 1300547 ON 4 D15312 (1300224..1300243,1300334..1300547) similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Protein involved in vacuolar H -ATPase assembly or function required for the biogenesis of a functional vacuolar ATPase (V-ATPase) but not part of the final enzyme complex KLLA0D15334g 0 1300663 1301466 ON 4 D15334 complement(1300663..1301466) weakly similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C Hypothetical ORF KLLA0D15356g 1 1301848 1303722 ON 4 D15356 (1301848..1303722) some similarities with uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways KLLA0D15378g 0 1303787 1306396 ON 4 D15378 complement(1303787..1306396) similar to uniprot|Q06593 Saccharomyces cerevisiae YPR194C OPT2 Oligopeptide transporter member of the OPT family with potential orthologs in S. pombe and C. albicans KLLA0D15400g 1 1307549 1308832 ON 4 D15400 (1307549..1308832) weakly similar to uniprot|Q0CQA0 Aspergillus terreus NIH2624 ATEG_04134 Predicted protein Klac_4.trna30L 1 1309318 1309399 ON 4 tL-GAG (1309318..1309399) tRNA Type: Leu (L) | Anti-Codon: GAG | Cove Score: 67.48 KLLA0D15455g 1 1309647 1310870 ON 4 D15455 (1309647..1310870) similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W Methylthioribose-1-phosphate isomerase catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5- methylthioribulose-1-phosphate in the methionine salvage pathway Klac_4.trna31K 0 1311081 1311170 ON 4 tK-UUU complement(1311081..1311116,1311134..1311170) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 KLLA0D15521g 1 1311601 1312371 ON 4 D15521 (1311601..1312371) similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation; peroxisomal 2,4- dienoyl-CoA reductase KLLA0D15543g 1 1313760 1315379 ON 4 D15543 (1313760..1315379) similar to uniprot|P24869 Saccharomyces cerevisiae YPR119W CLB2 Involved in mitotic induction G(sub)2- specific B-type cyclin and uniprot|P24868 Saccharomyces cerevisiae YGR108W CLB1 KLLA0D15565g 0 1316125 1317351 ON 4 D15565 complement(1316125..1317351) similar to uniprot|P30283 Saccharomyces cerevisiae YPR120C CLB5 B-type cyclin with a role in DNA replication during S phase has an additional functional role in formation of mitotic spindles along with Clb3p and Clb4p and uniprot|P32943 Saccharomyces cerevisiae YGR109C CLB6, KLLA0D15576g 1 1318387 1318641 ON 4 D15576 (1318387..1318641) conserved hypothetical protein Klac_4.trna32Y 1 1318811 1318909 ON 4 tY-GUA (1318811..1318849,1318874..1318909) tRNA Type: Tyr (Y) | Anti-Codon: GUA | Cove Score: 70.95 KLLA0D15631g 1 1319185 1322697 ON 4 D15631 (1319185..1322697) similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a- factor mating pheromone required for axial budding pattern of haploid cells KLLA0D15653g 1 1323360 1324583 ON 4 D15653 (1323360..1324583) similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Hypothetical ORF Klac_4.trna33G 1 1325213 1325283 ON 4 tG-GCC (1325213..1325283) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0D15697g 1 1325624 1326070 ON 4 D15697 (1325624..1326070) highly similar to YBR252W, uniprot|P33317 Saccharomyces cerevisiae YBR252W (DUT1) KLLA0D15719g 1 1326369 1326734 ON 4 D15719 (1326369..1326734) similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Protein involved in transcription as part of the Srb/Mediator complex KLLA0D15741g 1 1327061 1328536 ON 4 D15741 (1327061..1328536) weakly similar to uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules important for chromosome segregation KLLA0D15763g 0 1328758 1329234 ON 4 D15763 complement(1328758..1329234) similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 Trapp subunit of 20 kDa probable membrane protein mutations in the human homolog cause spondyloepiphyseal dysplasia tarda (SEDL) a genetically heterogeneous disorder characterized by short stature and early-onset osteoarthritis Klac_4.trna34G 1 1329593 1329663 ON 4 tG-GCC (1329593..1329663) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0D15807g 1 1330010 1331644 ON 4 D15807 (1330010..1331644) some similarities with uniprot|P38335 Saccharomyces cerevisiae YBR255W Protein of unknown function required for normal growth rate at 15 degrees C green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0D15829g 0 1331795 1332157 ON 4 D15829 complement(1331795..1332157) similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Hypothetical ORF identified by homology KLLA0D15851g 0 1332568 1333569 ON 4 D15851 complement(1332568..1333569) some similarities with uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein that interacts with the karyopherin Srp1p KLLA0D15873g 1 1334131 1335426 ON 4 D15873 (1334131..1335426) similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Protein involved in a late step of 60S ribosomal subunit assembly or modification contains multiple WD repeats interacts with Qsr1p in the two-hybrid system KLLA0D15895g 0 1335523 1336230 ON 4 D15895 complement(1335523..1336230) highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase catalyzes the last step of the riboflavin biosynthesis pathway KLLA0D15917g 0 1336727 1338262 ON 4 D15917 complement(1336727..1338262) some similarities with uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease KLLA0D15939g 0 1339006 1339632 ON 4 D15939 complement(1339006..1339632) weakly similar to YIL016w KLLA0D15961g 1 1340141 1342984 ON 4 D15961 (1340141..1342984) weakly similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Vacuole import and degradation, KLLA0D15983g 1 1343315 1346422 ON 4 D15983 (1343315..1346422) similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase which is responsible for the conversion of sulfite into sulfide KLLA0D16005g 0 1346492 1350004 ON 4 D16005 complement(1346492..1350004) similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Component of the condensin complex essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase Smc2p/Smc4p complex binds DNA possibly in the cleft formed by the coiled-coil of the folded dimer KLLA0D16027g 0 1350451 1351692 ON 4 D16027 complement(1350451..1351211,1351689..1351692) highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W RPL2B and highly similar to uniprot|P05736 Saccharomyces cerevisiae YFR031C-A RPL2A, Protein component of the large (60S) ribosomal subunit KLLA0D16049g 0 1352380 1353657 ON 4 D16049 complement(1352380..1353657) some similarities with uniprot|P43607 Saccharomyces cerevisiae YFR032C Hypothetical ORF KLLA0D16071g 0 1354249 1354437 ON 4 D16071 complement(1354249..1354437) highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit KLLA0D16093g 0 1356056 1356424 ON 4 D16093 complement(1356056..1356424) weakly similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) KLLA0D16115g 0 1357504 1359573 ON 4 D16115 complement(1357504..1359573) conserved hypothetical protein KLLA0D16137g 0 1360619 1361644 ON 4 D16137 complement(1360619..1361644) similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly KLLA0D16148g 1 1361758 1362561 ON 4 D16148 (1361758..1362561) highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1- phosphoribosyl-4- imidazolecarboxiamide isomerase catalyzes the fourth step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts KLLA0D16170g 0 1362809 1363732 ON 4 D16170 complement(1362809..1363732) highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W KLLA0D16192g 1 1364216 1364581 ON 4 D16192 (1364216..1364581) conserved hypothetical protein KLLA0D16214g 0 1364989 1366245 ON 4 D16214 complement(1364989..1366245) highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 48.8 kDa protein involved in mitochondrial protein import KLLA0D16236g 0 1366718 1369333 ON 4 D16236 complement(1366718..1369333) weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0D16280g 1 1370792 1371301 ON 4 D16280 (1370792..1371301) similar to uniprot|Q12207 Saccharomyces cerevisiae YPR149W NCE102 and to uniprot|P53279 Saccharomyces cerevisiae YGR131W KLLA0D16302g 0 1372447 1373127 ON 4 D16302 complement(1372447..1373127) similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C KLLA0D16324g 0 1373445 1375538 ON 4 D16324 complement(1373445..1375538) weakly similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C KLLA0D16346g 1 1375653 1376647 ON 4 D16346 (1375653..1375790,1375880..1376647) similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Hypothetical ORF KLLA0D16368g 1 1376929 1378464 ON 4 D16368 (1376929..1378464) similar to uniprot|Q03761 Saccharomyces cerevisiae YDR145W, KLLA0D16390g 1 1378884 1381694 ON 4 D16390 (1378884..1381694) similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein specifically associated with the U3 snoRNA part of the large ribonucleoprotein complex known as the small subunit (SSU) processome required for 18S rRNA biogenesis part of the active pre- rRNA processing complex KLLA0D16412g 0 1382063 1383652 ON 4 D16412 complement(1382063..1383652) highly similar to uniprot|P11986 Saccharomyces cerevisiae YJL153C INO1 Inositol 1-phosphate synthase involved in synthesis of inositol phosphates and inositol- containing phospholipids transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p which bind the UASINO DNA element KLLA0D16434g 0 1384826 1386070 ON 4 D16434 complement(1384826..1386070) similar to uniprot|Q12436 Saccharomyces cerevisiae YLR130C ZRT2 Low-affinity zinc transporter of the plasma membrane transcription is induced under low-zinc conditions by the Zap1p transcription factor KLLA0D16456g 0 1387846 1390410 ON 4 D16456 complement(1387846..1390410) weakly similar to uniprot|P21192 Saccharomyces cerevisiae YLR131C ACE2 Transcription factor that activates expression of early G1-specific genes localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters localization is regulated by phosphorylation potential Cdc28p substrate KLLA0D16478g 0 1391173 1392027 ON 4 D16478 complement(1391173..1392027) weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Protein required for cell viability, KLLA0D16500g 1 1392680 1394293 ON 4 D16500 (1392680..1394293) similar to uniprot|P20485 Saccharomyces cerevisiae YLR133W CKI1 choline kinase KLLA0D16522g 0 1394850 1396256 ON 4 D16522 complement(1394850..1396256) some similarities with uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA, KLLA0D16544g 1 1397378 1399456 ON 4 D16544 (1397378..1399456) weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Subunit of a complex with Slx1p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p KLLA0D16566g 1 1399913 1407328 ON 4 D16566 (1399913..1407328) weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration localizes to the mother cell cortex and the bud tip may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex KLLA0D16588g 1 1407821 1410103 ON 4 D16588 (1407821..1410103) similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C KLLA0D16610g 0 1410447 1411379 ON 4 D16610 complement(1410447..1411379) similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C KLLA0D16632g 1 1412390 1413193 ON 4 D16632 (1412390..1413193) similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 RWD domain containing protein of unknown function KLLA0D16654g 0 1413507 1414706 ON 4 D16654 complement(1413507..1414706) similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes associates with the clathrin adaptor Gga2p clathrin adaptor complex AP-1 and clathrin KLLA0D16676g 0 1415185 1415673 ON 4 D16676 complement(1415185..1415673) highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis- trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds the drug cyclosporin A KLLA0D16709g 1 1416147 1416626 ON 4 D16709 (1416147..1416626) similar to uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14 KLLA0D16731g 1 1417095 1418189 ON 4 D16731 (1417095..1418189) highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase catalyzes the second step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis KLLA0D16753g 1 1418383 1419351 ON 4 D16753 (1418383..1419351) similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W Hypothetical ORF KLLA0D16775g 1 1419548 1423459 ON 4 D16775 (1419548..1423459) similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus KLLA0D16797g 1 1423833 1426538 ON 4 D16797 (1423833..1426538) similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W KLLA0D16830g 1 1426856 1429354 ON 4 D16830 (1426856..1429354) similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes KLLA0D16852g 1 1429676 1430800 ON 4 D16852 (1429676..1430800) similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W interacts with PP2C KLLA0D16874g 0 1430953 1431636 ON 4 D16874 complement(1430953..1431636) similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex found in the nucleus and cytoplasm contains an SH3 domain that binds Pbs2p KLLA0D16896g 1 1432077 1432640 ON 4 D16896 (1432077..1432640) similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W CWC15 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p KLLA0D16918g 0 1432797 1434845 ON 4 D16918 complement(1432797..1434845) weakly similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV coordinates expression of mitochondrially-encoded genes may facilitate delivery of mRNA to membrane-bound translation machinery KLLA0D16940g 1 1435379 1437001 ON 4 D16940 (1435379..1437001) weakly similar to uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Transcription factor member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p involved in transcription of rDNA by RNA polymerase I KLLA0D16962g 1 1437692 1439095 ON 4 D16962 (1437692..1439095) similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 proline oxidase KLLA0D16984g 1 1439669 1441759 ON 4 D16984 (1439669..1441759) similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Hypothetical ORF KLLA0D17006g 1 1442082 1443092 ON 4 D17006 (1442082..1443092) conserved hypothetical protein KLLA0D17028g 0 1443150 1445255 ON 4 D17028 complement(1443150..1445255) similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function KLLA0D17050g 0 1445796 1448216 ON 4 D17050 complement(1445796..1448216) similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1 3-endoglucanase expression is induced during sporulation may have a role in cortical actin cytoskeleton assembly KLLA0D17072g 1 1448823 1449473 ON 4 D17072 (1448823..1449473) weakly similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Protein required for cell viability component of RNase MRP which is involved in RNA processing in mitochondria KLLA0D17094g 0 1449542 1450432 ON 4 D17094 complement(1449542..1450432) similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine Synthase KLLA0D17116g 1 1451064 1452395 ON 4 D17116 (1451064..1452395) similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7- methylguanosine modification of tRNA KLLA0D17127g 1 1452651 1452881 ON 4 D17127 (1452651..1452881) conserved hypothetical protein KLLA0D17138g 0 1452972 1455731 ON 4 D17138 complement(1452972..1455731) similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis KLLA0D17160g 0 1456067 1456369 ON 4 D17160 complement(1456067..1456369) similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 involved in snRNP biogenesis and pre-mRNA splicing encodes a core snRNP protein KLLA0D17182g 1 1456620 1459394 ON 4 D17182 (1456620..1459394) similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins required for vacuolar biogenesis forms complex with Pep5p that mediates protein transport to the vacuole KLLA0D17204g 1 1459696 1460274 ON 4 D17204 (1459696..1460274) similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification KLLA0D17226g 1 1460573 1462060 ON 4 D17226 (1460573..1462060) similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone necessary for passage through the START phase of the cell cycle KLLA0D17248g 0 1462235 1464274 ON 4 D17248 complement(1462235..1464274) similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Hypothetical ORF KLLA0D17270g 0 1464854 1466383 ON 4 D17270 complement(1464854..1466383) weakly similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Protein that binds Sin3p in a two- hybrid assay, Klac_YGOB_STM1 1 1467581 1468724 ON 4 STM1 (1467581..1467586,1467981..1468724) ANNOTATED BY YGOB - unsure about exon 1 location KLLA0D17292g 0 1469265 1470254 ON 4 D17292 complement(1469265..1470254) similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids KLLA0D17314g 0 1471344 1473182 ON 4 D17314 complement(1471344..1473182) similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Hypothetical ORF KLLA0D17336g 0 1474026 1476080 ON 4 D17336 complement(1474026..1476080) uniprot|Q9Y7B5 Kluyveromyces lactis KLLA0D17336g ACS2 Acetyl-coenzyme A synthetase 2 KLLA0D17358g 0 1477523 1483069 ON 4 D17358 complement(1477523..1483069) similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi intra-Golgi transport and ER-to-Golgi transport found in the cytoplasm and on Golgi-associated coated vesicles KLLA0D17380g 1 1484192 1485490 ON 4 D17380 (1484192..1485490) highly similar to uniprot|Q6YFE5 Saccharomyces kluyveri GTP cyclohydrolase KLLA0D17402g 1 1485875 1486903 ON 4 D17402 (1485875..1486903) similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Protein involved in regulation of arginine- responsive and Mcm1p-dependent genes has a dual- specificity inositol polyphosphate kinase activity required for regulation of phosphate- and nitrogen- responsive genes KLLA0D17424g 0 1486955 1489057 ON 4 D17424 complement(1486955..1489057) uniprot|Q9HGI8 Kluyveromyces lactis KLLA0D17424g SUP35 Eukaryotic peptide chain release factor GTP-binding subunit KLLA0D17446g 0 1489480 1490667 ON 4 D17446 complement(1489480..1490667) similar to uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small cytosolic stress-induced chaperone that forms barrel-shaped oligomers and suppresses the aggregation of non-native proteins oligomer dissociation is not required for function involved in cytoskeleton reorganization after heat shock Klac_4.trna35Q 1 1492013 1492084 ON 4 tQ-UUG (1492013..1492084) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 69.31 KLLA0D17562r 0 1494671 1496382 ON 4 D17562r complement(1494671..1496382) RDN25-1 25S rRNA KLLA0D17600g 1 1495942 1496271 OFF 4 D17600 (1495942..1496271) some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand KLLA0D17633r 0 1496627 1496784 ON 4 D17633r complement(1496627..1496784) RDN58-1 5.8S rRNA KLLA0D17666r 0 1497012 1498810 ON 4 D17666r complement(1497012..1498810) RDN18-1 18S rRNA KLLA0D17677r 1 1500571 1500691 ON 4 D17677r (1500571..1500691) RDN5-1 5S rRNA KLLA0D17699r 0 1501738 1505101 OFF 4 D17699r complement(1501738..1505101) RDN25-1 25S rRNA KLLA0D17732g 1 1504661 1504990 OFF 4 D17732 (1504661..1504990) some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand KLLA0D17765r 0 1505346 1505504 OFF 4 D17765r complement(1505346..1505504) RDN58-2 5.8S rRNA KLLA0D17798r 0 1505732 1507529 OFF 4 D17798r complement(1505732..1507529) RDN18-1 18S rRNA KLLA0D17809r 1 1509282 1509402 OFF 4 D17809r (1509282..1509402) RDN5-1 5S rRNA KLLA0D17831r 0 1510449 1513812 OFF 4 D17831r complement(1510449..1513812) RDN25-1 25S rRNA KLLA0D17864g 1 1513372 1513701 OFF 4 D17864 (1513372..1513701) some similarities with uniprot|Q8TGM6 Saccharomyces cerevisiae YLR154W-C TAR1, Mitochondrial protein of unknown function, encoded within the 25S rRNA gene on the opposite strand KLLA0D17894r 0 1514057 1514214 OFF 4 D17894r complement(1514057..1514214) RDN58-1 5.8S rRNA KLLA0D17924r 0 1514442 1516238 OFF 4 D17924r complement(1514442..1516238) RDN18-1 18S rRNA KLLA0D17952g 0 1516386 1516715 OFF 4 D17952 complement(1516386..1516715) no similarity KLLA0D17935r 1 1517991 1518111 OFF 4 D17935r (1517991..1518111) RDN5-1 5S rRNA KLLA0D18029g 1 1521909 1522835 ON 4 D18029 (1521909..1521950,1522143..1522835) similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance rDNA- binding component of the Pol I transcription system associates with a 5'-3' DNA helicase and Fpr1p a prolyl isomerase KLLA0D18051g 0 1523490 1524401 ON 4 D18051 complement(1523490..1524401) similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit, KLLA0D18073g 1 1524750 1526666 ON 4 D18073 (1524750..1526666) similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes component of transcriptional adaptor and histone acetyltransferase complexes the ADA complex the SAGA complex and the SLIK complex KLLA0D18095g 0 1526808 1528217 ON 4 D18095 complement(1526808..1528217) highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins KLLA0D18117g 1 1529251 1529745 ON 4 D18117 (1529251..1529745) similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone KLLA0D18139g 0 1530325 1530801 ON 4 D18139 complement(1530325..1530801) similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin- like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling KLLA0D18161g 1 1531094 1532401 ON 4 D18161 (1531094..1532401) some similarities with uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Hypothetical ORF KLLA0D18172g 0 1532328 1533227 ON 4 D18172 complement(1532328..1533227) similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5, KLLA0D18194g 1 1533582 1538024 ON 4 D18194 (1533582..1538024) similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Sister chromatid cohesion protein KLLA0D18216g 0 1538132 1539148 ON 4 D18216 complement(1538132..1539148) weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181c SAS4 involved in silencing at telomere, KLLA0D18238g 1 1539699 1541135 ON 4 D18238 (1539699..1541135) similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative membrane protein of unknown function involved in Mn2 homeostasis mutants display actin and general growth defects heterogeneous cell cycle arrests and pleiotropic defects in cell cycle progression and organelle distribution KLLA0D18260g 0 1541154 1543607 ON 4 D18260 complement(1541154..1543607) similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis KLLA0D18282g 1 1544098 1544763 ON 4 D18282 (1544098..1544763) weakly similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W KLLA0D18304g 1 1545371 1545823 ON 4 D18304 (1545371..1545823) similar to uniprot|P04838 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B KLLA0D18326g 0 1546370 1547221 ON 4 D18326 complement(1546370..1547221) uniprot|Q6CQB7 Kluyveromyces lactis KLLA0D18326g ATC1 Protein ATC1/LIC4 KLLA0D18348g 0 1548080 1548787 ON 4 D18348 complement(1548080..1548787) similar to uniprot|P35200 Saccharomyces cerevisiae YLR168C possibly involved in intramitochondrial sorting, KLLA0D18370g 0 1549382 1550449 ON 4 D18370 complement(1549382..1550449) similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase composed of Erf2p and Shr5p that adds a palmitoyl lipid moiety to Ras2p through a thioester linkage mutants partially mislocalize Ras2p to the vacuole KLLA0D18392g 0 1550900 1553032 ON 4 D18392 complement(1550900..1553032) weakly similar to uniprot|Q04007 Saccharomyces cerevisiae YDR186C Hypothetical ORF KLLA0D18414g 1 1553985 1554428 ON 4 D18414 (1553985..1554428) similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified localizes to both the nucleus and cytoplasm KLLA0D18436g 1 1554955 1556082 ON 4 D18436 (1554955..1556082) highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map2p KLLA0D18458g 1 1556738 1558372 ON 4 D18458 (1556738..1558372) highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p essential protein that is required for the assembly of actin and tubulins in vivo contains an ATP-binding motif KLLA0D18480g 1 1558735 1560663 ON 4 D18480 (1558735..1560663) similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex, KLLA0D18502g 0 1560764 1562137 ON 4 D18502 complement(1560764..1562137) highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 RUVB-like protein TIP49a Homologue KLLA0D18535g 1 1562984 1564183 ON 4 D18535 (1562984..1564183) similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD( )-dependent protein deacetylases involved along with Hst3p in silencing at telomeres cell cycle progression radiation resistance genomic stability and short-chain fatty acid metabolism KLLA0D18557g 0 1564372 1565277 ON 4 D18557 complement(1564372..1565277) highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Protein required for cell viability Klac_YGOB_Anc_8.398 0 1565442 1567220 ON 4 Anc_8.398 complement(1565442..1567220) ANNOTATED BY YGOB - KLLA0D18601g 1 1567554 1568462 ON 4 D18601 (1567554..1568462) similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C, KLLA0D18623g 0 1568498 1570837 ON 4 D18623 complement(1568498..1570837) similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Hypothetical ORF KLLA0D18645g 0 1571106 1573694 ON 4 D18645 complement(1571106..1573694) similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; similar to p110 subunit of mammalian PI 3-kinase KLLA0D18667g 0 1574160 1576217 ON 4 D18667 complement(1574160..1576217) similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns presumed RNA helicase due to DEAD-box motif KLLA0D18689g 1 1577545 1578942 ON 4 D18689 (1577545..1578942) similar to uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation also involved in snoRNA maturation KLLA0D18711g 0 1579086 1579946 ON 4 D18711 complement(1579086..1579946) similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C predicted to catalyze the final step in synthesis of Coenzyme A KLLA0D18733g 1 1580743 1581855 ON 4 D18733 (1580743..1581855) similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Translational activator of COB mRNA soluble protein cytochrome b translational activator KLLA0D18755g 0 1581943 1583328 ON 4 D18755 complement(1581943..1583328) similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C Hypothetical ORF KLLA0D18777g 1 1583574 1584572 ON 4 D18777 (1583574..1584572) uniprot|O13476 Kluyveromyces lactis KLLA0D18777g LIPB Lipoate-protein ligase, mitochondrial precursor KLLA0D18799g 0 1584644 1586047 ON 4 D18799 complement(1584644..1586047) similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C VPS64 KLLA0D18821g 1 1586393 1586854 ON 4 D18821 (1586393..1586854) similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle KLLA0D18843g 0 1586889 1587956 ON 4 D18843 complement(1586889..1587956) similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p Rav2p Skp1p) a complex that associates with the V1 domain of the vacuolar membrane (H )-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme KLLA0D18865g 1 1588334 1589332 ON 4 D18865 (1588334..1589332) similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis possibly functioning in stabilization of Coq7p located on the matrix face of the mitochondrial inner membrane KLLA0D18887g 1 1590084 1592333 ON 4 D18887 (1590084..1592333) similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Nuclear protein of unknown function deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C deletion is synthetically lethal with a chitin synthase (CHS1) null mutant KLLA0D18909g 0 1592628 1593500 ON 4 D18909 complement(1592628..1593500) similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 late sporulation specific gene which may function during spore wall formation peroxisomal 2 4- dienoyl-CoA reductase KLLA0D18942g 1 1594560 1595633 ON 4 D18942 (1594560..1595633) similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C GCS1 ADP-ribosylation factor GTPase activating protein KLLA0D18964g 0 1595893 1596930 ON 4 D18964 complement(1595893..1596930) weakly similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 diacylglycerol pyrophosphate phosphatase KLLA0D18986g 1 1597391 1598770 ON 4 D18986 (1597391..1598770) similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105 disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes. KLLA0D19008g 0 1598807 1600075 ON 4 D19008 complement(1598807..1600075) highly similar to uniprot|P40160 YNL207W Saccharomyces cerevisiae RIO2 Protein required for cell viability, KLLA0D19041g 0 1600915 1602756 ON 4 D19041 complement(1600915..1602756) highly similar to uniprot|P40150 Saccharomyces cerevisiae YNL209W SSB2 Ribosome-associated molecular chaperone heat shock protein of HSP70 family proposed to be involved in the folding of newly synthesized polypeptide chains homolog of SSB1 KLLA0D19063g 0 1603523 1604338 ON 4 D19063 complement(1603523..1604338) weakly similar to uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis- specific mRNA splicing; required for chromosome pairing and meiotic recombination Klac_YGOB_Anc_2.39b 0 1604747 1605717 ON 4 Anc_2.39b complement(1604747..1605352,1605355..1605717) ANNOTATED BY YGOB - Klac_YGOB_Anc_2.39 0 1604747 1605361 OFF 4 Anc_2.39 complement(1604747..1605361) ANNOTATED BY YGOB - KLLA0D19118g 1 1606789 1609926 ON 4 D19118 (1606789..1609926) similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A a drug which is known to affect intracellular transport KLLA0D19129g 0 1610176 1610295 ON 4 D19129 complement(1610176..1610295) highly similar to uniprot|Q99380 Saccharomyces cerevisiae YDL232W OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; type I membrane protein of 36 residues that binds Stt3p and Ost3p together in a subcomplex KLLA0D19140g 1 1610589 1610849 ON 4 D19140 (1610589..1610849) similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Hypothetical ORF KLLA0D19162g 0 1611324 1612193 ON 4 D19162 complement(1611324..1612193) some similarities with uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Vacuole import and degradation , KLLA0D19184g 1 1613134 1613862 ON 4 D19184 (1613134..1613862) similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C Hypothetical ORF KLLA0D19206g 0 1614045 1614632 ON 4 D19206 complement(1614045..1614632) similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane protein component of the peroxisomal translocation machinery required for peroxisome biogenesis binds Pex14p KLLA0D19228g 0 1615062 1617185 ON 4 D19228 complement(1615062..1617185) weakly similar to uniprot|Q07684 Saccharomyces cerevisiae YDL233W Hypothetical ORF KLLA0D19250g 0 1617539 1618561 ON 4 D19250 complement(1617539..1618561) weakly similar to uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions KLLA0D19272g 1 1618994 1621222 ON 4 D19272 (1618994..1621222) similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective) Ypt1p Ypt31p and Ypt32p (in vitro) involved in vesicle mediated protein trafficking KLLA0D19294g 0 1621376 1623376 ON 4 D19294 complement(1621376..1623376) uniprot|Q01073 Kluyveromyces lactis KLLA0D19294g RAP1 DNA-binding protein KLLA0D19316g 0 1623976 1624908 ON 4 D19316 complement(1623976..1624908) similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Hypothetical ORF KLLA0D19338g 1 1628572 1628979 ON 4 D19338 (1628572..1628979) similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus KLLA0D19360g 0 1629360 1631039 ON 4 D19360 complement(1629360..1631039) similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome interacts functionally with DNA polymerase delta homolog of human Werner helicase interacting protein (WHIP), KLLA0D19382g 0 1631334 1632263 ON 4 D19382 complement(1631334..1632263) similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p- nitrophenyl phosphate involved in dephosphorylation of histone II-A and casein KLLA0D19404g 1 1632929 1634590 ON 4 D19404 (1632929..1634590) similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 catalyzes the transfer of mannose from Dol-P- Man to lipid-linked oligosaccharides mannosyltransferase, KLLA0D19426g 0 1634755 1636053 ON 4 D19426 complement(1634755..1636053) highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase catalyzes the first committed step in the 'de novo' biosynthesis of adenosine KLLA0D19448g 1 1637541 1639994 ON 4 D19448 (1637541..1639994) similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P KLLA0D19470g 0 1641182 1642441 ON 4 D19470 complement(1641182..1642441) weakly similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W Hypothetical ORF KLLA0D19492g 1 1643703 1645193 ON 4 D19492 (1643703..1645193) similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures KLLA0D19514g 0 1645274 1645897 ON 4 D19514 complement(1645274..1645897) similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p exhibits intrinsic phosphatase activity affects start site selection in vivo Nuclear zinc-finger motif containing protein. KLLA0D19536g 0 1646330 1647682 ON 4 D19536 complement(1646330..1647682) similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Cysteine protease required for autophagy cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p, KLLA0D19558g 1 1647949 1650171 ON 4 D19558 (1647949..1650171) similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C Hypothetical ORF KLLA0D19580g 1 1650584 1652848 ON 4 D19580 (1650584..1652848) weakly similar to uniprot|Q07732 Saccharomyces cerevisiae YDL239C ADY3 Protein required for spore wall formation thought to mediate assembly of a Don1p- containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components potentially phosphorylated by Cdc28p KLLA0D19602g 1 1653096 1654958 ON 4 D19602 (1653096..1654958) similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Protein that may function as a cochaperone as suggested by the presence of a DnaJ-like domain KLLA0D19624g 1 1655546 1656715 ON 4 D19624 (1655546..1656715) uniprot|Q96X43 Kluyveromyces lactis Ure2p KLLA0D19646g 1 1657122 1658066 ON 4 D19646 (1657122..1658066) weakly similar to uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A F-box protein that forms a heterodimer with Elc1p and participates in transcription elongation Klac_YGOB_Anc_2.12 1 1658882 1659918 ON 4 Anc_2.12 (1658882..1659268,1659271..1659918) ANNOTATED BY YGOB - Artificial frameshift correction KLLA0D19701g 0 1660119 1661012 ON 4 D19701 complement(1660119..1661012) similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Subunit of the exosome which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation KLLA0D19723g 0 1661329 1663800 ON 4 D19723 complement(1661329..1663800) similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase localized to the bud neck required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p KLLA0D19745g 0 1664368 1665660 ON 4 D19745 complement(1664368..1665660) similar to uniprot|Q75E71 Ashbya gossypii ABL201W ABL201Wp and some similarites with YNL234W uniprot|P53857 Saccharomyces cerevisiae YNL234W Similar to globins and has a functional heme-binding domain involved in glucose signaling or metabolism regulated by Rgt1p KLLA0D19767g 0 1667231 1670101 ON 4 D19767 complement(1667231..1670101) similar to uniprot|P32259 YNL236W Saccharomyces cerevisiae SIN4 involved in positive and negative regulation of transcription KLLA0D19789g 0 1670586 1671872 ON 4 D19789 complement(1670586..1671872) similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W KLLA0D19811g 0 1672338 1674608 ON 4 D19811 complement(1672338..1674608) uniprot|P09231 Kluyveromyces lactis KLLA0D19811g KEX1 protease precursor KLLA0D19833g 1 1675407 1676816 ON 4 D19833 (1675407..1676816) uniprot|P53998 Kluyveromyces lactis LET1 PROTEIN KLLA0D19855g 1 1678342 1679835 ON 4 D19855 (1678342..1679835) uniprot|P48828 Kluyveromyces lactis G6PD ZWF Glucose-6- phosphate 1-dehydrogenase KLLA0D19877g 0 1680043 1683015 ON 4 D19877 complement(1680043..1683015) similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity appears to specifically regulate 1 3-beta-glucan synthesis KLLA0D19899g 0 1683427 1687935 ON 4 D19899 complement(1683427..1687935) similar to uniprot|P53855 YNL242W Saccharomyces cerevisiae ATG2 Peripheral membrane protein required for the formation of cytosolic sequestering vesicles involved in vacuolar import through both the Cvt pathway and autophagy KLLA0D19921g 1 1690012 1690863 ON 4 D19921 (1690012..1690863) similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein transcription is induced under low-zinc conditions as mediated by the Zap1p transcription factor and at alkaline pH KLLA0D19929g 1 1694826 1695986 ON 4 D19929 (1694826..1695986) weakly similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase KLLA0D19933g 0 1696360 1697166 ON 4 D19933 complement(1696360..1697166) weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase KLLA0D19941g 0 1698889 1700724 ON 4 D19941 complement(1698889..1700724) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF KLLA0D19945g 1 1701681 1703615 ON 4 D19945 (1701681..1703615) similar to uniprot|P36173 Saccharomyces cerevisiae YKR106W KLLA0D19949g 0 1703696 1704247 ON 4 D19949 complement(1703696..1704247) conserved hypothetical protein KLLA0D19953g 0 1704481 1705842 ON 4 D19953 complement(1704481..1705842) similar to uniprot|P53048 Saccharomyces cerevisiae YGR289C MAL11 Maltose permease inducible high-affinity maltose transporter (alpha-glucoside transporter) encoded in the MAL1 complex locus member of the 12 transmembrane domain superfamily of sugar transporters KLLA0D19957g 1 1705967 1706491 ON 4 D19957 (1705967..1706491) some similarities with uniprot|Q08295 Saccharomyces cerevisiae YOL157C Hypothetical ORF KLLA0D19965g 0 1706982 1707422 ON 4 D19965 complement(1706982..1707422) conserved hypothetical protein KLLA0D19987g 1 1708507 1708974 ON 4 D19987 (1708507..1708974) conserved hypothetical protein KLLA0D20009g 0 1709412 1710935 ON 4 D20009 complement(1709412..1710935) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0D20031g 0 1711728 1712774 ON 4 D20031 complement(1711728..1712774) conserved hypothetical protein KLLA0E00111g 1 2681 3727 ON 5 E00111 (2681..3727) conserved hypothetical protein KLLA0E00133g 1 4528 6051 ON 5 E00133 (4528..6051) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0E00155g 0 6738 6956 ON 5 E00155 complement(6738..6956) no similarity KLLA0E00177g 1 8041 8481 ON 5 E00177 (8041..8481) no similarity KLLA0E00221g 1 9200 10468 ON 5 E00221 (9200..10468) similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite KLLA0E00243g 1 11467 11862 ON 5 E00243 (11467..11862) similar to uniprot|Q06597 YPR200C Saccharomyces cerevisiae ARR2 Arsenate reductase required for arsenate resistance KLLA0E00265g 1 12033 12899 ON 5 E00265 (12033..12899) weakly similar to uniprot|Q06596 Saccharomyces cerevisiae YPR199C ARR1 Transcriptional activator of the bZIP family required for transcription of genes involved in resistance to arsenic compounds KLLA0E00287g 1 15302 16837 ON 5 E00287 (15302..16837) weakly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily KLLA0E00309g 1 17100 18608 ON 5 E00309 (17100..18608) conserved hypothetical protein KLLA0E00397g 1 23256 25637 ON 5 E00397 (23256..25637) highly similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family KLLA0E00419g 1 28957 31341 ON 5 E00419 (28957..31341) similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Plasma membrane transporter that transports tetra- and pentapeptides and glutathione member of the OPT family KLLA0E00441g 1 32524 34200 ON 5 E00441 (32524..34200) similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W Hypothetical ORF KLLA0E00463g 0 34713 35664 ON 5 E00463 complement(34713..35130,35651..35664) highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 yeast cortical cytoskeleton component mammalian cofilin homolog Cofilin actin binding and severing protein KLLA0E00485g 1 36083 36628 ON 5 E00485 (36083..36628) no similarity KLLA0E00507g 1 37469 39076 ON 5 E00507 (37469..39076) similar to uniprot|P38734 Saccharomyces cerevisiae YHL036W MUP3 Low affinity methionine permease, similar to Mup1p KLLA0E00529g 0 39173 44125 ON 5 E00529 complement(39173..44125) similar to uniprot|P32386 Saccharomyces cerevisiae YLL048C KLLA0E00551g 0 45755 46483 ON 5 E00551 complement(45755..46483) similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C SBP1 Single-strand nucleic acid binding protein KLLA0E00573g 0 47961 48728 ON 5 E00573 complement(47961..48728) highly similar to uniprot|P29453 Saccharomyces cerevisiae RPL8B and to YHL033C uniprot|P17076 Saccharomyces cerevisiae RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit KLLA0E00595g 0 49243 51228 ON 5 E00595 complement(49243..51228) similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase converts glycerol to glycerol- 3-phosphate glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p derepression of expression on non- fermentable carbon sources is mediated by Opi1p and Rsf1p KLLA0E00617g 1 53103 54794 ON 5 E00617 (53103..54794) weakly similar to uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane glycerol channel member of the major intrinsic protein (MIP) family of channel proteins involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite KLLA0E00639g 0 54895 55542 ON 5 E00639 complement(54895..55542) similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport homolog of the mammalian protein GOS-28/GS28 KLLA0E00661g 0 55858 56325 ON 5 E00661 complement(55858..56325) weakly similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy KLLA0E00683g 0 57323 58087 ON 5 E00683 complement(57323..58087) highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone KLLA0E00705g 0 59404 68778 ON 5 E00705 complement(59404..68778) similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 homologous to human COH1 component of peripheral vacuolar membrane protein complex KLLA0E00727g 1 69141 74684 ON 5 E00727 (69141..74684) similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Major component of the proteasome tethers the proteasome core particle to the regulatory particle and enhances the stability of the proteasome KLLA0E00749g 0 74948 76093 ON 5 E00749 complement(74948..76093) highly similar to uniprot|P04838 Saccharomyces cerevisiae YLL039c UBI4 ubiquitin KLLA0E00771g 1 78021 79361 ON 5 E00771 (78021..79361) some similarities with uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 cell wall integrity and stress response component 4 Putative integral membrane protein containing novel cysteine motif. Similarity to SLG1 (WSC1) WSC2 and WSC3 KLLA0E00793g 1 80516 82069 ON 5 E00793 (80516..82069) weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W KLLA0E00815g 1 82495 84390 ON 5 E00815 (82495..84390) similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Protein of unknown function required for cell growth and possibly involved in rRNA processing mRNA is cell cycle regulated KLLA0E00837g 0 84426 86870 ON 5 E00837 complement(84426..86870) highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family required for export of pre-ribosomal large subunits from the nucleus distributed between the nucleolus nucleoplasm and nuclear periphery depending on growth conditions KLLA0E00859g 1 87256 87822 ON 5 E00859 (87256..87822) weakly similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W KLLA0E00881g 0 87991 90132 ON 5 E00881 complement(87991..90132) weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Hypothetical ORF KLLA0E00903g 1 92292 98297 ON 5 E00903 (92292..98297) similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis required for bud emergence KLLA0E00925g 0 98423 99586 ON 5 E00925 complement(98423..99586) similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Translocase of the mitochondrial inner membrane mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane interacts with mitochondrial ribosomes null is respiratory deficient KLLA0E00947g 1 100123 100968 ON 5 E00947 (100123..100968) similar to uniprot|P10355 Saccharomyces cerevisiae YER153C translational activator of cytochrome C oxidase subunit III KLLA0E00969g 1 101430 102767 ON 5 E00969 (101430..102767) similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Hypothetical ORF KLLA0E00991g 1 103562 104317 ON 5 E00991 (103562..104317) similar to uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Suppressor of hydroxy-urea sensitivity KLLA0E01013g 1 104991 107315 ON 5 E01013 (104991..107315) some similarities with uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments inhibitor of gene silencing cleaves ubiquitin fusions but not polyubiquitin KLLA0E01035g 1 109821 115457 ON 5 E01035 (109821..115457) some similarities with uniprot|P08640 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein required for diploid pseudohyphal formation and haploid invasive growth transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p) KLLA0E01057g 0 116315 116800 ON 5 E01057 complement(116315..116800) some similarities with uniprot|Q01589 Saccharomyces cerevisiae YDR077w SED1 abundant cell surface glycoprotein KLLA0E01079g 0 117963 119204 ON 5 E01079 complement(117963..119204) some similarities with uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single- stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad57p KLLA0E01101g 1 119812 120573 ON 5 E01101 (119812..120573) similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit Klac_5.trna1K 1 120819 120908 ON 5 tK-UUU (120819..120855,120873..120908) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 KLLA0E01145g 0 121191 122633 ON 5 E01145 complement(121191..122633) highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p Sbh1p and Sss1p) forms a channel for SRP- dependent protein import and retrograde transport of misfolded proteins out of the ER with Sec63 complex allows SRP-independent protein import into ER KLLA0E01167g 0 123073 124512 ON 5 E01167 complement(123073..124512) similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C KLLA0E01189g 0 124802 125227 ON 5 E01189 complement(124802..125227) some similarities with uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system KLLA0E01211g 1 126280 127347 ON 5 E01211 (126280..127347) highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1 6-bisphosphatase key regulatory enzyme in the gluconeogenesis pathway required for glucose metabolism KLLA0E01233g 0 127544 128491 ON 5 E01233 complement(127544..128491) similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 fatty acyltransferase KLLA0E01255g 1 128932 129558 ON 5 E01255 (128932..129558) weakly similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C KLLA0E01277g 1 129929 130729 ON 5 E01277 (129929..130729) similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein KLLA0E01299g 0 130994 131779 ON 5 E01299 complement(130994..131779) similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta- glucan assembly null mutation leads to severe growth defects aberrant multibudded morphology and mating defects KLLA0E01321g 1 132673 134538 ON 5 E01321 (132673..134538) some similarities with uniprot|Q03795 Saccharomyces cerevisiae YMR155W Hypothetical ORF KLLA0E01343g 0 134691 137207 ON 5 E01343 complement(134691..137207) similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway acts in complex with Pmt2p dolichyl phosphate-D-mannose:protein O-D- mannosyltransferase KLLA0E01365g 1 138197 139474 ON 5 E01365 (138197..139474) highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome the human homolog (S9 protein) partially rescues Rpn6p depletion KLLA0E01387g 0 139568 140275 ON 5 E01387 complement(139568..140275) similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in the repair of endogenous DNA damage; functionally redundant with Apn1p and Apn2p KLLA0E01409g 1 140505 141065 ON 5 E01409 (140505..141065) similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 23 kD U4/U6.U5 snRNP associated protein Putative RNA binding zinc finger protein KLLA0E01431g 0 141256 141909 ON 5 E01431 complement(141256..141909) similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C FMP39 The authentic non-tagged protein was localized to the mitochondria KLLA0E01453g 1 142457 142924 ON 5 E01453 (142457..142924) highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit KLLA0E01475g 0 143257 144213 ON 5 E01475 complement(143257..144213) weakly similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0E01497g 1 144767 145816 ON 5 E01497 (144767..145816) highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C ARR4 ATPase involved in resistance to heat and metal stress active as a dimer normally localized to the cytosol but appears to localize to late endosomes under stress conditions Klac_5.trna2M 0 146055 146127 ON 5 tM-CAU complement(146055..146127) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 KLLA0E01541g 0 146269 146649 ON 5 E01541 complement(146269..146649) some similarities with uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Protein that interacts with the Atg12p-Atg5p conjugate during formation of the pre- autophagosomal structure essential for autophagy KLLA0E01563g 1 146955 149105 ON 5 E01563 (146955..149105) similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Hypothetical ORF KLLA0E01585g 1 149305 150960 ON 5 E01585 (149305..149370,149488..150960) similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes phosphorylation of Rad55p and Sml1p and transient G2/M arrest after DNA damage also regulates postreplicative DNA repair KLLA0E01607g 0 151015 154320 ON 5 E01607 complement(151015..154320) highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W CDC2 Catalytic subunit of DNA polymerase delta required for chromosomal DNA replication during mitosis and meiosis intragenic recombination repair of double strand DNA breaks and DNA replication during nucleotide excision repair (NER) KLLA0E01629g 1 155088 155783 ON 5 E01629 (155088..155783) similar to uniprot|P48353 Saccharomyces cerevisiae YMR161W KLLA0E01651g 0 155975 160627 ON 5 E01651 complement(155975..160627) similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Non-essential P-type ATPase that is a potential aminophospholipid translocase localizes to the trans-Golgi likely involved in protein transport KLLA0E01673g 1 161221 162633 ON 5 E01673 (161221..162633) similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase catalyzes the formation of UDP-N-acetylglucosamine (UDP- GlcNAc) which is important in cell wall biosynthesis protein N-glycosylation and GPI anchor biosynthesis KLLA0E01695g 0 162748 164748 ON 5 E01695 complement(162748..164748) weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0E01717g 0 165223 166842 ON 5 E01717 complement(165223..166842) some similarities with uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation controls the activation of MUC1 and STA2 in response to nutritional signals KLLA0E01739g 0 167644 168996 ON 5 E01739 complement(167644..168996) weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Specific translational activator for the COX3 mRNA that acts together with Pet54p and Pet122p located in the mitochondrial inner membrane KLLA0E01761g 1 169765 170334 ON 5 E01761 (169765..170334) weakly similar to uniprot|P26188 Saccharomyces cerevisiae YDL200c, DNA repair methyltransferase (6-O- methylguanine-DNA methylase) involved in protection against DNA alkylation damage KLLA0E01783g 1 171319 173037 ON 5 E01783 (171319..173037) similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138w, glucose receptor KLLA0E01805g 0 173125 174093 ON 5 E01805 complement(173125..174093) similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 catabolism of hydroxy amino acids catabolic serine (threonine) dehydratase KLLA0E01827g 1 174481 175047 ON 5 E01827 (174481..175047) similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Decapping enzyme essential phosphoprotein component of mRNA decapping complex plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradation regulated by DEAD box protein Dhh1p KLLA0E01849g 0 175162 176991 ON 5 E01849 complement(175162..176991) weakly similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex involved in maintaining the integrity of the complex KLLA0E01871g 0 177514 178218 ON 5 E01871 complement(177514..178218) similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation most abundant protein in the peroxisomal membrane regulated by Adr1p and Pip2p-Oaf1p promoter contains ORE and UAS1-like elements KLLA0E01893g 1 179231 179797 ON 5 E01893 (179231..179797) similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery KLLA0E01915g 0 180022 183243 ON 5 E01915 complement(180022..183243) similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes including cyclin genes contains TPR repeats KLLA0E01937g 1 183638 185092 ON 5 E01937 (183638..185092) similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis KLLA0E01959g 0 185188 185691 ON 5 E01959 complement(185188..185691) highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6 7-dimethyl-8- ribityllumazine synthase also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin KLLA0E01981g 0 186177 187475 ON 5 E01981 complement(186177..187475) highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase regulates transcription and silencing KLLA0E02003g 0 187814 190816 ON 5 E02003 complement(187814..190816) similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 Required for peroxisome assembly Member of the AAA-protein family that includes NSFp and PEX1p KLLA0E02025g 0 191062 191502 ON 5 E02025 complement(191062..191502) similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Protein of the mitochondrial inner membrane function partially overlaps that of Mdj1p which is a chaperone involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix member of the DnaJ family KLLA0E02047g 1 192747 194939 ON 5 E02047 (192747..194939) weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)- anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner KLLA0E02069g 0 195185 196162 ON 5 E02069 complement(195185..196162) weakly similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p one of three yeast DHHC-cysteine rich domain proteins (Pfa3p Erf2p Akr1p) with palmitoyltransferase activity required for vacuolar integrity under stress conditions KLLA0E02091g 1 196450 197172 ON 5 E02091 (196450..197172) similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Ribosomal RNA Processing Rrp40p KLLA0E02113g 0 197197 199797 ON 5 E02113 complement(197197..199797) similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Protein required for efficient mating member of a family of eukaryotic proteins that contain a domain homologous to Sac1p KLLA0E02135g 0 200436 202055 ON 5 E02135 complement(200436..202055) similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C SNG1 Protein involved in nitrosoguanidine resistance and weakly similar to YJR015W uniprot|P47090 Saccharomyces cerevisiae YJR015W Hypothetical ORF KLLA0E02157g 0 202891 203262 ON 5 E02157 complement(202891..203262) no similarity KLLA0E02179g 1 203854 205143 ON 5 E02179 (203854..205143) similar to uniprot|P42838 YNL323W Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER KLLA0E02201g 0 205466 207973 ON 5 E02201 complement(205466..207973) weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 classified as an early recombination function required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth) required for double strand breaks meiotic recombination and spore viability DNA repair protein KLLA0E02223g 0 208267 209709 ON 5 E02223 complement(208267..209709) conserved hypothetical protein KLLA0E02245g 0 210001 211212 ON 5 E02245 complement(210001..211212) weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Hypothetical ORF KLLA0E02267g 1 212406 212717 ON 5 E02267 (212406..212717) conserved hypothetical protein KLLA0E02289g 0 212983 213583 ON 5 E02289 complement(212983..213350,213571..213583) highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin actin- and phosphatidylinositol 4 5-bisphosphate-binding protein plays a role in cytoskeleton organization required for normal timing of actin polymerization in response to thermal stress localizes to plasma membrane and cytosol KLLA0E02311g 0 214032 215285 ON 5 E02311 complement(214032..215285) similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex which associates with RNA polymerase II and is involved in histone methylation KLLA0E02333g 1 215594 217036 ON 5 E02333 (215594..217036) similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Sporulation-specific chitinase KLLA0E02355g 0 217222 218196 ON 5 E02355 complement(217222..218196) highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74 KLLA0E02377g 0 218647 222309 ON 5 E02377 complement(218647..222309) uniprot|O42726 Kluyveromyces lactis UBP2 Ubiquitin carboxyl-terminal hydrolase 2 KLLA0E02399g 1 223247 223819 ON 5 E02399 (223247..223819) highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4- kinase Pik1p member of the recoverin/frequenin branch of the EF-hand superfamily KLLA0E02421g 0 224180 224890 ON 5 E02421 complement(224180..224890) highly similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis essential for several other metabolic pathways including respiration and gluconeogenic gene activation KLLA0E02443g 0 225413 226207 ON 5 E02443 complement(225413..226207) some similarities with uniprot|Q06390 Saccharomyces cerevisiae YDR374C Hypothetical ORF KLLA0E02465g 1 226664 226921 ON 5 E02465 (226664..226921) similar to uniprot|Q2V2P8 Saccharomyces cerevisiae YDR374W-A KLLA0E02487g 0 227048 228388 ON 5 E02487 complement(227048..228388) highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone required for the assembly of the cytochrome bc(1) complex from the Rip1p and Qcr10p proteins member of the CDC48/PAS1/SEC18 ATPase family KLLA0E02509g 0 228652 229377 ON 5 E02509 complement(228652..229377) similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate which is particularly important in sake brewing KLLA0E02531g 1 229894 231330 ON 5 E02531 (229894..231330) similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster- containing enzymes one of the few mitochondrial proteins essential for viability KLLA0E02553g 1 231758 232467 ON 5 E02553 (231758..231814,232222..232467) highly similar to uniprot|Q06405 Saccharomyces cerevisae YDR377w, ATP synthase subunit f, ATP17 KLLA0E02575g 0 233160 233402 ON 5 E02575 complement(233160..233402) similar to uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay KLLA0E02597g 1 234517 237654 ON 5 E02597 (234517..237654) weakly similar to uniprot|P39083 Saccharomyces cerevisiae YOR127W RGA1 GTPase-activating protein for the polarity-establishment protein Cdc42p implicated in control of septin organization pheromone response and haploid invasive growth KLLA0E02619g 0 237959 238198 ON 5 E02619 complement(237959..238198) similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Hypothetical ORF KLLA0E02641g 1 239180 240838 ON 5 E02641 (239180..240838) uniprot|Q8TGC8 Kluyveromyces lactis Putative ceramide glucosyltransferase KLLA0E02663g 1 244696 248025 ON 5 E02663 (244696..248025) conserved hypothetical protein KLLA0E02685g 0 248162 249871 ON 5 E02685 complement(248162..249871) similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway red pigment accumulates in mutant cells deprived of adenine KLLA0E02707g 1 251220 253115 ON 5 E02707 (251220..253115) similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde which is the first specific step in the Ehrlich pathway KLLA0E02729g 0 253382 256117 ON 5 E02729 complement(253382..256117) weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C Putative component of the outer plaque of the spindle pole body may be involved in cation homeostasis or multidrug resistance KLLA0E02751g 1 256959 258863 ON 5 E02751 (256959..257213,258450..258863) similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 Nuclear protein that binds to RNA and to Mex67p required for export of poly(A) mRNA from the nucleus member of the REF (RNA and export factor binding proteins) family another family member Yra2p can substitute for Yra1p function KLLA0E02773g 0 259296 259619 ON 5 E02773 complement(259296..259619) similar to uniprot|Q3E6R5 Saccharomyces cerevisiae YDR381C-A Hypothetical ORF identified by homology KLLA0E02795g 1 260349 260516 ON 5 E02795 (260349..260516) no similarity KLLA0E02817g 1 260854 261768 ON 5 E02817 (260854..261768) weakly similar to uniprot|P39953 Saccharomyces cerevisiae YEL006W Hypothetical ORF9 KLLA0E02839g 0 261895 262749 ON 5 E02839 complement(261895..262749) similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane exports ornithine from mitochondria as part of arginine biosynthesis human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome KLLA0E02861g 1 263645 263974 ON 5 E02861 (263645..263974) similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm KLLA0E02883g 0 264203 264835 ON 5 E02883 complement(264203..264835) similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C KLLA0E02905g 0 265432 266232 ON 5 E02905 complement(265432..266232) similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters KLLA0E02927g 0 267778 268788 ON 5 E02927 complement(267778..268788) some similarities with uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein regulation pattern suggests a possible role in export of ammonia from the cell member of the TC 9.B.33 YaaH family of putative transporters KLLA0E02949g 0 270871 271603 ON 5 E02949 complement(270871..271412,271513..271603) similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Hypothetical ORF KLLA0E02971g 1 271880 273535 ON 5 E02971 (271880..273535) similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Peripheral membrane protein required for vacuolar protein sorting KLLA0E02993g 1 274095 276623 ON 5 E02993 (274095..276623) highly similar to uniprot|P32324 Saccharomyces cerevisiae YOR133W EFT1 and to uniprot|P32324 Saccharomyces cerevisiae YDR385W EFT2 Elongation factors KLLA0E03015g 1 277093 278937 ON 5 E03015 (277093..278937) similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Helix-hairpin-helix protein involved in DNA repair and replication fork stability functions as an endonuclease in complex with Mms4p interacts with Rad54p KLLA0E03037g 0 278965 280587 ON 5 E03037 complement(278965..280587) similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Hypothetical ORF KLLA0E03059g 1 281543 282829 ON 5 E03059 (281543..282829) similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 BAR adaptor protein subunit of a complex (Rvs161p-Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress KLLA0E03081g 1 284154 285815 ON 5 E03081 (284154..285815) similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W SAC7 and similar to uniprot|Q12128 Saccharomyces cerevisiae YOR134W BAG7 GTPase activating proteins KLLA0E03103g 0 286113 287987 ON 5 E03103 complement(286113..287987) similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation) which may play a role in protein targeting essential for viability KLLA0E03125g 1 288825 289931 ON 5 E03125 (288825..289931) highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD( )- dependent isocitrate dehydrogenase which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle KLLA0E03147g 0 290622 292358 ON 5 E03147 complement(290622..292358) weakly similar to uniprot|Q12212 Saccharomyces cerevisiae YOR137C SIA1 Suppressor of eIF5A High-copy suppressor of temperature-sensitive tif51A-1 KLLA0E03169g 0 292918 294552 ON 5 E03169 complement(292918..294552) weakly similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1 KLLA0E03191g 1 296592 298904 ON 5 E03191 (296592..298904) some similarities with uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcription factor with domains homologous to Hsf1p and to myc oncoprotein required for normal cell surface assembly and flocculence KLLA0E03213g 0 299014 301380 ON 5 E03213 complement(299014..301380) similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes KLLA0E03235g 1 302753 303709 ON 5 E03235 (302753..303709) similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate KLLA0E03257g 0 304025 304939 ON 5 E03257 complement(304025..304939) similar to uniprot|P35202 YOR143C Saccharomyces cerevisiae THI80 Thiamine pyrophosphokinase KLLA0E03279g 1 305245 306231 ON 5 E03279 (305245..306231) uniprot|O13472 Kluyveromyces lactis KLLA0E03212g SPT3 Protein KLLA0E03301g 0 306319 308568 ON 5 E03301 complement(306319..308568) weakly similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Protein required for S phase progression and telomere homeostasis KLLA0E03323g 0 309039 309716 ON 5 E03323 complement(309039..309716) conserved hypothetical protein KLLA0E03345g 0 309713 310453 ON 5 E03345 complement(309713..310453) similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic KLLA0E03367g 1 310765 311457 ON 5 E03367 (310765..311457) highly similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing KLLA0E03411g 0 312058 312990 ON 5 E03411 complement(312058..312849,312943..312990) similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Protein involved in vacuolar protein sorting KLLA0E03433g 0 313281 314615 ON 5 E03433 complement(313281..314615) similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase KLLA0E03455g 0 314899 315900 ON 5 E03455 complement(314899..315278,315870..315900) highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W RPL27A and to uniprot|P38706 Saccharomyces cerevisiae YDR471W RPL27B proteins component of the large (60S) ribosomal subunit KLLA0E03477g 1 316716 317579 ON 5 E03477 (316716..317579) conserved hypothetical protein KLLA0E03499g 1 317949 319391 ON 5 E03499 (317949..319391) similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1 KLLA0E03521g 0 319500 319904 ON 5 E03521 complement(319500..319904) some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W SDC1 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; KLLA0E03543g 1 320167 320862 ON 5 E03543 (320167..320862) similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 member of the syntaxin family of t-SNAREs tSNARE that affects a Late Golgi compartment KLLA0E03565g 1 321977 323488 ON 5 E03565 (321977..323488) similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C Hypothetical ORF KLLA0E03587g 0 323764 325707 ON 5 E03587 complement(323764..325707) weakly similar to uniprot|Q03306 YDR466W Saccharomyces cerevisiae YDR466W Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant KLLA0E03609g 1 326893 327573 ON 5 E03609 (326893..327573) highly similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Manganese-containing superoxide dismutase KLLA0E03631g 1 327965 329188 ON 5 E03631 (327965..329188) similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine methyltransferase ribosomal protein L12 is a substrate KLLA0E03653g 1 329904 331487 ON 5 E03653 (329904..331487) highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase catalyzes the C-14 demethylation of lanosterol to form 4 4''-dimethyl cholesta-8 14 24-triene-3-beta-ol in the ergosterol biosynthesis pathway member of the cytochrome P450 family KLLA0E03675g 0 331890 335921 ON 5 E03675 complement(331890..335921) some similarities with uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 appears to control expression of spliceosome components PRP4 and PRP3 negative regulator of prp genes KLLA0E03697g 0 336505 338727 ON 5 E03697 complement(336505..338727) similar to uniprot|P32486 Saccharomyces cerevisiae YPR159W KRE6 Protein required for beta-1 6 glucan biosynthesis putative beta-glucan synthase appears functionally redundant with Skn1p KLLA0E03719g 0 340439 341320 ON 5 E03719 complement(340439..341320) conserved hypothetical protein Klac_5.trna3A 0 342576 342648 ON 5 tA-AGC complement(342576..342648) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0E03763g 0 342937 343965 ON 5 E03763 complement(342937..343965) some similarities with uniprot|P53286 Saccharomyces cerevisiae YGR142W BTN2 Cytosolic coiled-coil protein that modulates arginine uptake interacts with Rhb1p possible role in mediating pH homeostasis between the vacuole and plasma membrane H( )-ATPase may have a role in intracellular protein trafficking KLLA0E03785g 0 344351 345637 ON 5 E03785 complement(344351..345637) similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W VPS62 and similar to uniprot|Q06466 Saccharomyces cerevisiae YPR157W KLLA0E03807g 0 345816 348026 ON 5 E03807 complement(345816..348026) similar to uniprot|Q753I9 Ashbya gossypii AFR323W AFR323Wp and weakly similar to YGR140W uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere Cbf2p also binds to the CDEII region possibly forming a different multimeric complex ubiquitinated in vivo KLLA0E03829g 1 349784 351613 ON 5 E03829 (349784..351613) highly similar to uniprot|Q06451 Saccharomyces cerevisiae YPR156C TPO3 Polyamine transport protein KLLA0E03851g 1 352621 354423 ON 5 E03851 (352621..354423) some similarities with uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase functions with Nca3p KLLA0E03873g 0 354700 355362 ON 5 E03873 complement(354700..355362) similar to uniprot|Q06449 Saccharomyces cerevisiae YPR154W PIN3 Protein that induces appearance of [PIN ] prion when overproduced KLLA0E03895g 0 355734 356234 ON 5 E03895 complement(355734..356151,356230..356234) similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Hypothetical ORF KLLA0E03917g 0 356540 357289 ON 5 E03917 complement(356540..357289) highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 20S proteasome beta-type subunit the only nonessential 20S subunit KLLA0E03939g 1 357695 359002 ON 5 E03939 (357695..359002) similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C Hypothetical ORF KLLA0E03961g 0 358995 362393 ON 5 E03961 complement(358995..362393) weakly similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily- conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation KLLA0E03983g 1 363400 363975 ON 5 E03983 (363400..363975) similar to gnl|GLV|CAGL0L08426g Candida glabrata CAGL0L08426g and weakly similar to YPR151C uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c KLLA0E04005g 0 364475 364888 ON 5 E04005 complement(364475..364888) weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C MMF1 Mitochondrial protein involved in maintenance of the mitochondrial genome and weakly similar to YER057C uniprot|P40037 Saccharomyces cerevisiae YER057C HMF1 Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high- dosage growth inhibitor; forms a homotrimer in vitro KLLA0E04027g 0 365119 365595 ON 5 E04027 complement(365119..365595) similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Involved in peroxisome biogenesis Member of ubiquitin-conjugating protein family KLLA0E04049g 1 366535 368304 ON 5 E04049 (366535..368304) similar to uniprot|P12630 Saccharomyces cerevisiae YIL015W BAR1 Aspartyl protease secreted into the periplasmic space of mating type a cells, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest and to YLR121C uniprot|Q12303 Saccharomyces cerevisiae YLR121C YPS3 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YLR120C uniprot|P32329 Saccharomyces cerevisiae YLR120C YPS1 Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor and to YDR144C uniprot|P53379 Saccharomyces cerevisiae YDR144C MKC7 GPI- anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p and to YIR039C uniprot|P40583 Saccharomyces cerevisiae YIR039C YPS6 Putative GPI-anchored aspartic protease, member on vGLC.1466. KLLA0E04071g 1 369201 371315 ON 5 E04071 (369201..371315) some similarities with uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase controls turnover of a specific class of unstable nuclear proteins including Sir4p but not Sir2p or Sir3p san1 mutations suppress sir4 spt16 and cdc68 mutations suggesting a role in chromatin silencing KLLA0E04093g 1 371642 372760 ON 5 E04093 (371642..372760) similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) Member of beta-transducin-related (WD-40) protein family KLLA0E04115g 0 372858 373421 ON 5 E04115 complement(372858..373421) weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome suppressor of rna1-1 mutation may be involved in RNA export from nucleus KLLA0E04137g 0 373677 375335 ON 5 E04137 complement(373677..375335) similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex essential for viability and mitotic growth homolog of SWI/SNF subunit Swi3p but unlike Swi3p does not activate transcription of reporters KLLA0E04159g 1 375999 378479 ON 5 E04159 (375999..378479) similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W Hypothetical ORF KLLA0E04181g 1 378888 380288 ON 5 E04181 (378888..380288) similar to uniprot|P07278 YIL033C Saccharomyces cerevisiae BCY1 Regulatory subunit of the cyclic AMP- dependent protein kinase (PKA) KLLA0E04203g 0 380555 381004 ON 5 E04203 complement(380555..381004) highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3- ketoreductase and/or tether these enzymes to the ER also interacts with Erg6p KLLA0E04225g 1 381615 382454 ON 5 E04225 (381615..382454) similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization localized predominantly to cortical actin patches KLLA0E04247g 1 382874 383995 ON 5 E04247 (382874..383995) similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 alpha subunit of protein kinase CK2 Klac_YGOB_MEI4 0 384124 385340 ON 5 MEI4 complement(384124..385221,385311..385340) ANNOTATED BY YGOB - unsure about coordinates of exon 1 KLLA0E04269g 0 386095 387441 ON 5 E04269 complement(386095..387441) weakly similar to uniprot|P40535 Saccharomyces cerevisiae YIL036W CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family activates transcription of genes involved in utilization of non- optimal carbon sources KLLA0E04291g 1 388682 389479 ON 5 E04291 (388682..389479) some similarities with uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensible for both nuclear divisions during meiosis KLLA0E04313g 1 389694 391448 ON 5 E04313 (389694..391448) weakly similar to uniprot|P40534 Saccharomyces cerevisiae YIL037C Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p, PRM2 KLLA0E04335g 1 391816 394092 ON 5 E04335 (391816..394092) similar to uniprot|Q75AN0 Ashbya gossypii ADL108C ADL108Cp and some similarites with YIL038C uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4- NOT complex which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation KLLA0E04357g 0 394269 395390 ON 5 E04357 complement(394269..395390) conserved hypothetical protein KLLA0E04379g 0 396027 398216 ON 5 E04379 complement(396027..398216) similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family interacts with the Sin1p transcriptional repressor in the two-hybrid system KLLA0E04401g 0 398654 400030 ON 5 E04401 complement(398654..400030) similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W Hypothetical ORF KLLA0E04423g 0 400495 401781 ON 5 E04423 complement(400495..401781) similar to uniprot|P39101 YER048C Saccharomyces cerevisiae CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family KLLA0E04445g 0 402193 402642 ON 5 E04445 complement(402193..402642) conserved hypothetical protein KLLA0E04467g 1 403312 403587 ON 5 E04467 (403312..403587) similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A KLLA0E04489g 1 404611 406413 ON 5 E04489 (404611..406413) similar to uniprot|P40032 Saccharomyces cerevisiae YER049W Hypothetical ORF KLLA0E04511g 0 406764 407672 ON 5 E04511 complement(406764..407672) similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 Golgi-vesicle protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm KLLA0E04533g 1 408415 409680 ON 5 E04533 (408415..409680) similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF KLLA0E04555g 0 409814 410281 ON 5 E04555 complement(409814..410281) some similarities with uniprot|P40033 Saccharomyces cerevisiae YER050C KLLA0E04577g 0 410511 410897 ON 5 E04577 complement(410511..410897) no similarity KLLA0E04599g 0 411182 411559 ON 5 E04599 complement(411182..411559) no similarity KLLA0E04621g 1 412009 413178 ON 5 E04621 (412009..413178) some similarites with uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0E04643g 0 413277 413942 ON 5 E04643 complement(413277..413942) similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 SYnthetic lethal with cdcForty (putative) involved in pre-mRNA splicing KLLA0E04665g 1 414183 416126 ON 5 E04665 (414183..416126) similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0E04687g 0 416178 417098 ON 5 E04687 complement(416178..417098) similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Hypothetical ORF KLLA0E04709g 0 417351 417851 ON 5 E04709 complement(417351..417851) weakly similar to uniprot|P53274 Saccharomyces cerevisiae YGR126W Hypothetical ORF KLLA0E04731g 0 418094 421276 ON 5 E04731 complement(418094..421276) similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Hypothetical ORF KLLA0E04753g 0 423256 424248 ON 5 E04753 complement(423256..424248) similar to uniprot|P52919 Saccharomyces cerevisiae YLR457C NBP1 Component of the mitotic apparatus containing a coiled-coil domain essential for the G2/M transition KLLA0E04775g 1 424886 427018 ON 5 E04775 (424886..427018) similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon) required for normal yeast chromosomal replication expression peaks at the G1/S phase boundary potential Cdc28p substrate KLLA0E04797g 0 427096 428070 ON 5 E04797 complement(427096..428070) highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p KLLA0E04819g 1 428278 429657 ON 5 E04819 (428278..429657) similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor component of the U4/U6-U5 snRNP complex KLLA0E04841g 0 429714 431624 ON 5 E04841 complement(429714..431624) similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C, Subunit of a possibly tetrameric trichostatin A- sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex KLLA0E04863g 1 432000 433140 ON 5 E04863 (432000..432027,432140..433140) similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W, RHC31 nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability KLLA0E04885g 0 433298 435580 ON 5 E04885 complement(433298..435580) highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 cytoplasmic GTPase-activating protein KLLA0E04907g 1 436221 437399 ON 5 E04907 (436221..437399) similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins may have a role in recognition of the attachment signal or of the lipid portion of GPI KLLA0E04929g 1 437719 438168 ON 5 E04929 (437719..437721,437833..438168) similar to uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Sm or Sm-like snRNP protein Klac_5.trna4W 0 438507 438614 ON 5 tW-CCA complement(438507..438542,438579..438614) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 66.91 Klac_YGOB_Anc_4.253a 0 439069 439278 ON 5 Anc_4.253a complement(439069..439278) ANNOTATED BY YGOB - KLLA0E04973g 0 439551 440402 ON 5 E04973 complement(439551..440402) similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase interacts genetically with ATP6 KLLA0E04995g 0 440889 441635 ON 5 E04995 complement(440889..441635) some similarities with uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Secretory Stress Response protein KLLA0E05017g 0 442199 443101 ON 5 E05017 complement(442199..443101) similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly- synthesized class I peroxisomal membrane proteins KLLA0E05039g 1 443446 443919 ON 5 E05039 (443446..443919) highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway nuclear protein required for S- and M-phase cyclin degradation and mitotic control involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) KLLA0E05061g 0 444262 446112 ON 5 E05061 complement(444262..446112) similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C KLLA0E05083g 0 446469 446741 ON 5 E05083 complement(446469..446741) some similarities with uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Non-essential protein of unknown function KLLA0E05105g 1 447645 450659 ON 5 E05105 (447645..450659) similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved with homolog Axl1p in N-terminal processing of pro-a-factor to the mature form member of the insulin-degrading enzyme family KLLA0E05127g 0 451432 451602 ON 5 E05127 complement(451432..451602) highly similar to uniprot|P41058 Saccharomyces cerevisiae YDL061C RPS29B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins KLLA0E05149g 1 452736 455099 ON 5 E05149 (452736..455099) similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre- rRNA in the cytoplasm associates with pre-40S ribosomal particles KLLA0E05171g 1 455399 456664 ON 5 E05171 (455399..456664) similar to uniprot|Q06709 Saccharomyces cerevisiae YLR387C CREH1 Protein of unknown function, similar to Rei1p but not involved in bud growth KLLA0E05193g 0 456708 459436 ON 5 E05193 complement(456708..459331,459433..459436) similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Activator of Fab1p KLLA0E05215g 1 459726 460103 ON 5 E05215 (459726..460103) weakly similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7 KLLA0E05237g 1 460483 464460 ON 5 E05237 (460483..464460) highly similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of RNA polymerase II elongator complex which is a histone acetyltransferase involved in maintaining structural integrity of the complex iki3 mutations confer resistance to the K. lactis toxin zymocin KLLA0E05259g 0 464593 465222 ON 5 E05259 complement(464593..465222) similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double- strand breaks in DNA during vegetative growth via recombination and single-strand annealing anneals complementary single-stranded DNA KLLA0E05281g 1 467253 472520 ON 5 E05281 (467253..472520) similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 involved intracellular protein transport coiled-coil protein necessary for protein transport from ER to Golgi Integrin analogue gene KLLA0E05303g 0 472583 475879 ON 5 E05303 complement(472583..475879) similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W RHC18 Protein involved in structural maintenance of chromosomes required for interchromosomal and sister chromatid recombination KLLA0E05325g 1 476546 479173 ON 5 E05325 (476546..479173) similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase also has a direct role in splicing of several mitochondrial group I introns indirectly required for mitochondrial genome maintenance KLLA0E05347g 0 479196 481070 ON 5 E05347 complement(479196..481070) similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p may bind the kinetochore to spindle microtubules KLLA0E05369g 0 481399 482733 ON 5 E05369 complement(481399..482733) similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in lipid turnover interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance KLLA0E05391g 1 483509 485374 ON 5 E05391 (483509..485374) similar to uniprot|Q07379 Saccharomyces cerevisiae YDL057W Hypothetical ORF KLLA0E05413g 1 485919 488183 ON 5 E05413 (485919..488183) uniprot|P39679 Kluyveromyces lactis MBP1 Transcription factor MBP1 KLLA0E05435g 0 488881 489966 ON 5 E05435 complement(488881..489966) highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) synthesizes GDP- mannose from GTP and mannose-1-phosphate in cell wall biosynthesis required for normal cell wall structure KLLA0E05457g 0 490709 491107 ON 5 E05457 complement(490709..491107) no similarity KLLA0E05479g 0 491391 493229 ON 5 E05479 complement(491391..493229) similar to uniprot|P38196 YBL042C Saccharomyces cerevisiae FUI1 High affinity uridine permease localized to the plasma membrane not involved in uracil transport KLLA0E05501g 0 494499 495056 ON 5 E05501 complement(494499..495056) similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome KLLA0E05523g 1 495340 495831 ON 5 E05523 (495340..495831) similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA KLLA0E05545g 1 496271 498007 ON 5 E05545 (496271..498007) highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C KLLA0E05567g 0 498639 499106 ON 5 E05567 complement(498639..499106) highly similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cu Zn superoxide dismutase some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans Klac_YGOB_Anc_7.478 0 500026 500214 ON 5 Anc_7.478 complement(500026..500214) ANNOTATED BY YGOB - KLLA0E05589g 1 500522 501631 ON 5 E05589 (500522..501631) conserved hypothetical protein KLLA0E05611g 1 501887 502703 ON 5 E05611 (501887..501911,502069..502703) similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 Integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum has a role in maintenance of normal levels of ER-resident proteins KLLA0E05633g 0 502868 503590 ON 5 E05633 complement(502868..503590) highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 20S proteasome beta-type subunit KLLA0E05655g 0 503859 505592 ON 5 E05655 complement(503859..505592) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions KLLA0E05677g 0 506394 507089 ON 5 E05677 complement(506394..507089) conserved hypothetical protein KLLA0E05699g 1 509158 510495 ON 5 E05699 (509158..510495) similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex) which is a component of the mitochondrial inner membrane electron transport chain KLLA0E05721g 0 511336 512544 ON 5 E05721 complement(511336..512544) some similarities with uniprot|P38193 Saccharomyces cerevisiae YBL046W Hypothetical ORF KLLA0E05743g 1 513485 514279 ON 5 E05743 (513485..514279) similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit KLLA0E05765g 0 514352 514798 ON 5 E05765 complement(514352..514798) similar to uniprot|Q3E743 Saccharomyces cerevisiae YJR112W-A KLLA0E05787g 1 515081 518767 ON 5 E05787 (515081..518767) weakly similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins binds membranes in a ubiquitin-dependent manner may also bind ubiquitinated membrane-associated proteins KLLA0E05809g 0 518890 519507 ON 5 E05809 complement(518890..519507) similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules required for accurate chromosome segregation KLLA0E05831g 1 519783 520610 ON 5 E05831 (519783..520610) similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Hypothetical ORF KLLA0E05853g 0 520702 522591 ON 5 E05853 complement(520702..522591) similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate KLLA0E05875g 0 523476 523850 ON 5 E05875 complement(523476..523850) similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1 KLLA0E05897g 0 525092 527233 ON 5 E05897 complement(525092..527233) weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W FRE3 Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters KLLA0E05919g 0 530194 531294 ON 5 E05919 complement(530194..531042,531265..531294) highly similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17 KLLA0E05941g 0 531676 532448 ON 5 E05941 complement(531676..531952,532447..532448) highly similar to uniprot|P49631 Saccharomyces cerevisiae YJR094W-A RPL43B Protein component of the large (60S) ribosomal subunit and highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W RPL43A Protein component of the large (60S) ribosomal subunit KLLA0E05963g 1 534222 534857 ON 5 E05963 (534222..534857) similar to uniprot|P21190 Saccharomyces cerevisiae YJR094C IME1 Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p KLLA0E05985g 1 535755 536642 ON 5 E05985 (535755..536642) some similarities with uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor KLLA0E06007g 0 536856 540509 ON 5 E06007 complement(536856..540509) weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Protein involved in bud-site selection and required for axial budding pattern localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding potential Cdc28p substrate KLLA0E06029g 1 541992 545276 ON 5 E06029 (541992..545276) similar to uniprot|P47135 Saccharomyces cerevisiae YJR091C JSN1 Member of the Puf family of RNA-binding proteins and to uniprot|Q12221 Saccharomyces cerevisiae YPR042C PUF2 mRNA binding protein KLLA0E06051g 1 545879 549598 ON 5 E06051 (545879..549598) similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin- ligase complex required for Cln1p and Cln2p degradation involved in carbon catabolite repression glucose-dependent divalent cation transport high-affinity glucose transport and morphogenesis KLLA0E06073g 0 549775 552111 ON 5 E06073 complement(549775..552111) some similarities with uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Protein involved in cell cycle regulation and chromosome segregation contains BIR (Baculovirus Inhibitor of apoptosis Repeat) domain KLLA0E06095g 0 552686 553882 ON 5 E06095 complement(552686..553882) similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 eIF5 mediates hydrolysis of eIF2-GTP (SUI2 SUI3 GCD11) at start codons Translation initiation factor eIF-5 KLLA0E06117g 1 554413 555273 ON 5 E06117 (554413..555273) similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C Hypothetical ORF KLLA0E06139g 0 555427 556638 ON 5 E06139 complement(555427..556638) similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein involved in regulation of the TOR pathway KLLA0E06161g 1 557120 557731 ON 5 E06161 (557120..557731) similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen involved in disulfide bond formation within the ER KLLA0E06183g 0 557869 558141 ON 5 E06183 complement(557869..558141) similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit forms a dimer with Ste4p to activate the mating signaling pathway forms a heterotrimer with Gpa1p and Ste4p to dampen signaling C- terminus is palmitoylated and farnesylated which are required for normal signaling KLLA0E06205g 1 558694 559011 ON 5 E06205 (558694..559011) similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Hypothetical ORF Klac_YGOB_Anc_7.453 0 559405 559530 ON 5 Anc_7.453 complement(559405..559530) ANNOTATED BY YGOB - KLLA0E06227g 0 560535 561809 ON 5 E06227 complement(560535..561809) weakly similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W CSN12 Subunit of the Cop9 signalosome which is required for deneddylation or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin) involved in adaptation to pheromone signaling KLLA0E06249g 1 562140 562781 ON 5 E06249 (562140..562781) some similarities with uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization potential Cdc28p substrate KLLA0E06271g 0 562886 564268 ON 5 E06271 complement(562886..564268) similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 vacuolar ATPase V1 domain subunit H (54 kDa) KLLA0E06293g 0 564871 565989 ON 5 E06293 complement(564871..565989) highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS) synthesizes glutamine from glutamate and ammonia with Glt1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation KLLA0E06315g 0 567309 568625 ON 5 E06315 complement(567309..568625) similar to uniprot|Q75BT7 Ashbya gossypii ACR184C ACR184Cp and weakly similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Actin-related protein involved in transcriptional regulation subunit of the chromatin remodeling Snf/Swi complex KLLA0E06337g 1 569076 569423 ON 5 E06337 (569076..569423) some similarities with uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Esa1p-associated factor subunit of the NuA4 acetyltransferase complex KLLA0E06359g 1 570159 571193 ON 5 E06359 (570159..571193) weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C FMP26 The authentic non-tagged protein was localized to the mitochondria KLLA0E06381g 1 571704 573293 ON 5 E06381 (571704..573293) highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase encoded by a single nuclear gene that specifies two messages efficient mitochondrial localization requires both a presequence and an amino- terminal sequence KLLA0E06403g 0 573381 573974 ON 5 E06403 complement(573381..573974) similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Hypothetical ORF KLLA0E06425g 0 574273 577239 ON 5 E06425 complement(574273..577239) similar to uniprot|Q12038 Saccharomyces cerevisiae YPR032W SRO7 Suppressor of rho3 yeast homolog of the Drosphila tumor suppressor lethal giant larvae or similar to YBL106C uniprot|P38163 Saccharomyces cerevisiae YBL106C SRO77 Suppressor of defect in the small GTPase Rho3p yeast homolog of the Drosphila tumor suppressor lethal giant larvae KLLA0E06447g 0 577669 581154 ON 5 E06447 complement(577669..581154) uniprot|Q8J213 Kluyveromyces lactis KLLA0E06413g PKC1 Protein kinase C KLLA0E06469g 0 581935 584832 ON 5 E06469 complement(581935..584832) similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C Hypothetical ORF KLLA0E06491g 0 585024 587207 ON 5 E06491 complement(585024..587207) similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Component of the histone acetyltransferase complex KLLA0E06513g 0 587745 589223 ON 5 E06513 complement(587745..589223) weakly similar to uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein Rtg1p to activate the retrograde (RTG) and TOR pathways KLLA0E06535g 1 589706 590347 ON 5 E06535 (589706..590347) highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W KLLA0E06557g 0 590423 593785 ON 5 E06557 complement(590423..593785) some similarities with uniprot|P38167 Saccharomyces cerevisiae YBL101C ECM21 Non-essential protein of unknown function promoter contains several Gcn4p binding elements KLLA0E06579g 1 594361 596763 ON 5 E06579 (594361..596763) similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin large subunit of the clathrin- associated protein (AP) complex KLLA0E06601g 0 596942 597586 ON 5 E06601 complement(596942..597433,597536..597586) similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Protein that regulates vesicular traffic in stressed cells either to facilitate membrane turnover or to decrease unnecessary secretion Klac_5.trna5F 1 597877 597949 ON 5 tF-GAA (597877..597949) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 76.93 KLLA0E06645g 0 598212 601655 ON 5 E06645 complement(598212..601655) similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Vacuolar acid trehalase required for trehalose utilization KLLA0E06667g 1 603277 604923 ON 5 E06667 (603277..604923) highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis KLLA0E06689g 1 605566 606762 ON 5 E06689 (605566..606762) similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters KLLA0E06711g 0 607187 609496 ON 5 E06711 complement(607187..609496) highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Mitochondrial inner membrane protease of the AAA family responsible for degradation of unfolded or misfolded mitochondrial gene products mutation causes an elevated rate of mitochondrial turnover KLLA0E06733g 0 609924 612242 ON 5 E06733 complement(609924..612242) similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Essential protein required for chromosome condensation likely to function as an intrinsic component of the condensation machinery may influence multiple aspects of chromosome transmission and dynamics KLLA0E06755g 0 612941 614944 ON 5 E06755 complement(612941..614944) weakly similar to uniprot|P30606 Saccharomyces cerevisiae YOL103W ITR2 Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively KLLA0E06777g 1 616703 617452 ON 5 E06777 (616703..617452) similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Hypothetical ORF KLLA0E06799g 1 618131 619678 ON 5 E06799 (618131..619678) similar to uniprot|P38682 Saccharomyces cerevisiae YER122C KLLA0E06821g 0 620417 621037 ON 5 E06821 complement(620417..621037) similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 RNA polymerase II holoenzyme component KLLA0E06843g 1 622701 623093 ON 5 E06843 (622701..623093) highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit has similarity to rat L32 ribosomal protein KLLA0E06865g 0 624007 624831 ON 5 E06865 complement(624007..624831) similar to uniprot|P40075 Saccharomyces cerevisiae YER120W SCS2 Protein likely to be involved in regulating INO1 expression suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline involved in inositol metabolism regulator of INO1 expression KLLA0E06887g 0 625608 626864 ON 5 E06887 complement(625608..626864) similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides function is partially redundant with that of Map1p KLLA0E06909g 1 627257 627721 ON 5 E06909 (627257..627721) similar to gnl|GLV|CAGL0H04565g Candida glabrata CAGL0H04565g and some similarites with YBL090W uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the large subunit MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences KLLA0E06931g 1 628083 629453 ON 5 E06931 (628083..629453) similar to uniprot|P40074 Saccharomyces cerevisiae YER119C AVT6 Vacuolar transporter exports aspartate and glutamate from the vacuole and to YBL089W uniprot|P38176 Saccharomyces cerevisiae YBL089W AVT5 Putative transporter, members of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters KLLA0E06953g 1 629777 630850 ON 5 E06953 (629777..630850) uniprot|Q9P863 Kluyveromyces lactis sho1 Putative membrane protein KLLA0E06975g 0 631154 639439 ON 5 E06975 complement(631154..639439) similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation contributes to cell cycle checkpoint control in response to DNA damage functionally redundant with Mec1p homolog of human ataxia telangiectasia (ATM) gene KLLA0E06997g 0 639749 640671 ON 5 E06997 complement(639749..640120,640630..640671) highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W RPL23B Protein and highly similar to uniprot|P04451 Saccharomyces cerevisiae YBL087C RPL23A Protein, components of the large (60S) ribosomal subunit KLLA0E07019g 1 641391 642230 ON 5 E07019 (641391..642230) some similarities with uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Protein containing a RING finger domain that forms a complex with Hex3p mutant phenotypes and genetic interactions suggest a possible role in resolving recombination intermediates during DNA replication or repair KLLA0E07041g 1 642499 643074 ON 5 E07041 (642499..643074) some similarities with YER115c KLLA0E07063g 1 643888 645369 ON 5 E07063 (643888..645369) similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments ORF exhibits genomic organization compatible with a translational readthrough- dependent mode of expression KLLA0E07085g 1 645766 647124 ON 5 E07085 (645766..647124) similar to uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex KLLA0E07107g 0 647517 648884 ON 5 E07107 complement(647517..648884) similar to uniprot|Q75AV3 Ashbya gossypii ADL183C ADL183Cp and weakly similar to YOL136C uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2- kinase has negligible fructose-2 6-bisphosphatase activity inhibited by phosphoenolpyruvate and sn-glycerol 3- phosphate expression induced by glucose and sucrose transcriptional regulation involves protein kinase A KLLA0E07129g 0 650256 650897 ON 5 E07129 complement(650256..650897) similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C KLLA0E07151g 1 651474 651806 ON 5 E07151 (651474..651806) similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin- F-box ubiquitin protein ligases (SCF) required for Gic2p Far1p Sic1p and Cln2p degradation may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF KLLA0E07173g 0 652155 653090 ON 5 E07173 complement(652155..653090) similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase catalyzes the conversion of prephanate to phenylpyruvate which is a step in the phenylalanine biosynthesis pathway KLLA0E07195g 0 653477 654433 ON 5 E07195 complement(653477..654433) similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase KLLA0E07217g 1 654790 655617 ON 5 E07217 (654790..655617) some similarities with uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain KLLA0E07239g 0 655635 658325 ON 5 E07239 complement(655635..658325) similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C Protein required for cell viability KLLA0E07261g 0 658638 660974 ON 5 E07261 complement(658638..660974) similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter expression and turnover are regulated by Mg(2+) concentration overexpression confers increased tolerance to Al(3+) and Ga(3+) ions and similar to YFL050C uniprot|P43553 Saccharomyces cerevisiae YFL050C ALR2 Probable Mg(2+)transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions KLLA0E07283g 0 661677 662738 ON 5 E07283 complement(661677..662738) weakly similar to uniprot|P42845 Saccharomyces cerevisiae YNL309W STB1 Protein with a role in regulation of MBF-specific transcription at Start phosphorylated by Cln-Cdc28p kinases in vitro unphosphorylated form binds Swi6p and binding is required for Stb1p function expression is cell-cycle regulated KLLA0E07305g 1 663162 663737 ON 5 E07305 (663162..663737) similar to uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Essential component of the mitochondrial import system zinc finger protein that may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix KLLA0E07327g 1 664145 666142 ON 5 E07327 (664145..666142) similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C F-box protein KLLA0E07349g 0 666129 667541 ON 5 E07349 complement(666129..667541) similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 Putative 1,3-beta-glucanosyltransferase has similarity to Gas1p localizes to the cell wall KLLA0E07371g 0 667907 668590 ON 5 E07371 complement(667907..668590) similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Factor A (RF-A) which is a highly conserved single-stranded DNA binding protein involved in DNA replication repair and recombination KLLA0E07393g 0 669201 670967 ON 5 E07393 complement(669201..670967) similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis physically and functionally interacts with Krr1p KLLA0E07415g 1 671600 672130 ON 5 E07415 (671600..672130) similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68 KLLA0E07437g 0 672690 673787 ON 5 E07437 complement(672690..673787) highly similar to uniprot|P21965 Saccharomyces cerevisiae YNL307C MCK1 Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis related to mammalian glycogen synthase kinases of the GSK-3 family KLLA0E07459g 1 675010 675627 ON 5 E07459 (675010..675627) similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit essential for viability unlike most other mitoribosomal proteins KLLA0E07481g 1 676406 677449 ON 5 E07481 (676406..676418,677034..677449) highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit KLLA0E07503g 0 677690 678442 ON 5 E07503 complement(677690..678442) similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Hypothetical ORF KLLA0E07525g 0 678882 680096 ON 5 E07525 complement(678882..680096) similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in gluconeogenesis and glyoxylate cycle KLLA0E07547g 1 681586 682890 ON 5 E07547 (681586..682890) similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W Hypothetical ORF KLLA0E07569g 1 684098 685183 ON 5 E07569 (684098..685183) highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1 6-bisphosphate aldolase required for glycolysis and gluconeogenesis KLLA0E07591g 1 685564 686559 ON 5 E07591 (685564..686559) similar to uniprot|Q75DF9 Ashbya gossypii ABR067C ABR067Cp and weakly similar to YMR026C uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import forms translocation subcomplex with Pex2p and Pex10p KLLA0E07613g 0 686610 687218 ON 5 E07613 complement(686610..687218) no similarity KLLA0E07635g 0 687442 688389 ON 5 E07635 complement(687442..688389) similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit KLLA0E07657g 1 688734 690239 ON 5 E07657 (688734..690239) similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C KLLA0E07679g 0 690201 690515 ON 5 E07679 complement(690201..690515) conserved hypothetical protein KLLA0E07701g 1 690760 691908 ON 5 E07701 (690760..691908) weakly similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Hypothetical ORF KLLA0E07723g 0 691980 693332 ON 5 E07723 complement(691980..693332) similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Mannosidase GPI-anchored membrane protein required for cell wall biosynthesis homologous to Dfg5p KLLA0E07745g 0 693694 694191 ON 5 E07745 complement(693694..694191) highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W QRI8 Ubiquitin conjugating enzyme involved in the ER-associated protein degradation pathway requires Cue1p for recruitment to the ER membrane proposed to be involved in chromatin assembly KLLA0E07767g 1 694992 696401 ON 5 E07767 (694992..696401) similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport KLLA0E07789g 0 696382 697887 ON 5 E07789 complement(696382..697887) similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase converts spermine to spermidine which is required for the essential hypusination modification of translation factor eIF-5A also involved in pantothenic acid biosynthesis KLLA0E07811g 1 699154 700626 ON 5 E07811 (699154..700626) some similarities with uniprot|P40463 Saccharomyces cerevisiae YIL135C VHS2 Gene whose overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation KLLA0E07833g 0 701193 702044 ON 5 E07833 complement(701193..702044) highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome which is required for pre-18S rRNA processing interacts with Mpp10p member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs KLLA0E07855g 0 702486 704480 ON 5 E07855 complement(702486..704480) weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation involved in retrograde (RTG) mitochondria-to-nucleus signaling KLLA0E07877g 0 705849 707534 ON 5 E07877 complement(705849..707534) weakly similar to uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function major constituent of the mitochondrial outer membrane located on the outer (cytosolic) face of the outer membrane KLLA0E07899g 0 709306 710793 ON 5 E07899 complement(709306..710793) similar to gnl|GLV|CAGL0J10296g Candida glabrata CAGL0J10296g and weakly similar to YNL077W uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family overexpression interferes with propagation of the [Psi ] prion KLLA0E07921g 1 712370 715057 ON 5 E07921 (712370..715057) similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C RBF108 Hypothetical ORF KLLA0E07943g 0 715185 716660 ON 5 E07943 complement(715185..716660) weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase physically interacts with septins possibly involved in a mitotic signaling network KLLA0E07965g 1 717476 718648 ON 5 E07965 (717476..718648) similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein essential for cell growth and replication of M dsRNA virus contains four beta-transducin repeats KLLA0E07987g 0 718820 719938 ON 5 E07987 complement(718820..719938) similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD L-lysine- forming) catalyzes the conversion of saccharopine to L- lysine which is the final step in the lysine biosynthesis pathway KLLA0E08009g 1 720700 722865 ON 5 E08009 (720700..722865) similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition required for sporulation KLLA0E08031g 0 722953 724179 ON 5 E08031 complement(722953..724179) no similarity KLLA0E08053g 0 724562 725470 ON 5 E08053 complement(724562..725470) highly similar to uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6 KLLA0E08075g 0 725895 726792 ON 5 E08075 complement(725895..726251,726361..726792) similar to uniprot|P40580 Saccharomyces cerevisiae YIR036C IRC24 and to uniprot|P40579 Saccharomyces cerevisiae YIR035C KLLA0E08097g 1 727056 729026 ON 5 E08097 (727056..729026) similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes KLLA0E08119g 1 730334 735823 ON 5 E08119 (730334..735823) highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1 2 Urea amidolyase contains both urea carboxylase and allophanate hydrolase activities degrades urea to CO2 and NH3 expression sensitive to nitrogen catabolite repression and induced by allophanate an intermediate in allantoin degradation KLLA0E08141g 0 736008 737117 ON 5 E08141 complement(736008..737117) weakly similar to uniprot|P28496 Saccharomyces cerevisiae YKL008C LAC1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lag1p and similar to YHL003C uniprot|P38703 Saccharomyces cerevisiae YHL003C LAG1 Ceramide synthase component involved in synthesis of ceramide from C26(acyl)- coenzyme A and dihydrosphingosine or phytosphingosine functionally equivalent to Lac1p KLLA0E08163g 0 737811 738725 ON 5 E08163 complement(737811..738725) similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Component of RNA polymerase II holoenzyme involved in RNA pol II carboxy-terminal domain phosphorylation KLLA0E08207g 0 740213 741673 ON 5 E08207 complement(740213..741673) similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains mutations cause defects in cortical ER morphology in both the mother and daughter cells KLLA0E08229g 1 742066 744180 ON 5 E08229 (742066..744180) similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C Protein required for cell viability KLLA0E08251g 0 744523 744741 ON 5 E08251 complement(744523..744741) highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A Identified by gene-trapping microarray-based expression analysis and genome-wide homology searching KLLA0E08273g 1 745145 745930 ON 5 E08273 (745145..745930) similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit KLLA0E08295g 0 746166 746966 ON 5 E08295 complement(746166..746966) similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0E08317g 0 747272 750037 ON 5 E08317 complement(747272..750037) similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C KLLA0E08339g 1 750670 751779 ON 5 E08339 (750670..751779) highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine in which homo- isocitrate is oxidatively decarboxylated to alpha- ketoadipate KLLA0E08361g 0 751889 753364 ON 5 E08361 complement(751889..753364) similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C KLLA0E08383g 1 754048 756162 ON 5 E08383 (754048..756162) highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer deletion increases histone H2B H3 and H4 acetylation KLLA0E08405g 0 756205 758538 ON 5 E08405 complement(756205..758538) similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W PRK1 Protein serine/threonine kinase regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex Klac_5.trna6I 1 759480 759553 ON 5 tI-AAU (759480..759553) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 KLLA0E08449g 1 759718 760986 ON 5 E08449 (759718..760986) similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Hypothetical ORF KLLA0E08471g 1 761242 762957 ON 5 E08471 (761242..762957) similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB) which is involved in transcription of genes encoding tRNAs 5S rRNA U6 snRNA and other small RNAs KLLA0E08493g 1 763184 763639 ON 5 E08493 (763184..763639) weakly similar to uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-H protein KLLA0E08515g 1 764002 764973 ON 5 E08515 (764002..764973) similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Hypothetical ORF KLLA0E08537g 0 764998 766404 ON 5 E08537 complement(764998..766404) similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function required for survival upon exposure to K1 killer toxin involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains CTLH domain KLLA0E08559g 0 766878 768260 ON 5 E08559 complement(766878..768260) similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters KLLA0E08581g 1 768795 769619 ON 5 E08581 (768795..769619) similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis localized to the cytoplasm KLLA0E08603g 0 769789 770283 ON 5 E08603 complement(769789..770283) similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C Hypothetical ORF KLLA0E08625g 0 770773 771303 ON 5 E08625 complement(770773..771303) highly similar to uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 and highly similar to uniprot|P02303 Saccharomyces cerevisiae YBR010W HHT1 histone H3 proteins KLLA0E08647g 1 772323 772634 ON 5 E08647 (772323..772634) highly similar to uniprot|P02309 YBR009C and to uniprot|P02309 YNL030W Saccharomyces cerevisiae, HHF1 and HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity KLLA0E08669g 0 773082 774650 ON 5 E08669 complement(773082..774650) similar to uniprot|P53966 Saccharomyces cerevisiae YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family KLLA0E08691g 0 775085 776044 ON 5 E08691 complement(775085..776044) similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C KLLA0E08713g 1 777005 778795 ON 5 E08713 (777005..778795) some similarities with uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response nuclear localization is positively regulated by calcineurin-mediated dephosphorylation KLLA0E08735g 1 779165 780643 ON 5 E08735 (779165..780643) similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM complex) of the mitochondrial outer membrane the authentic non-tagged protein was localized to the mitochondria KLLA0E08757g 0 780776 781831 ON 5 E08757 complement(780776..781831) highly similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C Homolog to human PPCS KLLA0E08779g 1 782800 784227 ON 5 E08779 (782800..784227) similar to uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly(A) RNA-binding protein abundant mRNP- component protein hypothesized to bind a pool of non- translatable mRNAs not reported to associate with polyribosomes KLLA0E08801g 1 784991 787306 ON 5 E08801 (784991..787306) similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins cleaves at the C terminus of ubiquitin fusions irrespective of their size capable of cleaving polyubiquitin chains KLLA0E08823g 0 787451 787882 ON 5 E08823 complement(787451..787882) similar to uniprot|Q07541 Saccharomyces cerevisiae YDL121C Hypothetical ORF KLLA0E08845g 1 788296 788868 ON 5 E08845 (788296..788868) similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Yeast Frataxin Homologue mitochondrial protein that regulates mitochondrial iron accumulation KLLA0E08867g 1 789275 789505 ON 5 E08867 (789275..789505) similar to uniprot|P01095 Saccharomyces cerevisiae YNL015W PBI2 Cytosolic inhibitor of vacuolar proteinase B required for efficient vacuole inheritance with thioredoxin forms protein complex LMA1 which assists in priming SNARE molecules and promotes vacuole fusion KLLA0E08889g 1 789922 791007 ON 5 E08889 (789922..791007) similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis KLLA0E08911g 0 791157 792041 ON 5 E08911 complement(791157..792041) similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C KLLA0E08933g 0 792276 793067 ON 5 E08933 complement(792276..793067) weakly similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine KLLA0E08955g 1 793287 794315 ON 5 E08955 (793287..794315) similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p KLLA0E08977g 1 794616 797819 ON 5 E08977 (794616..797819) similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex which is required for transcriptional activation and also has a role in basal transcription KLLA0E08999g 0 797861 802330 ON 5 E08999 complement(797861..802330) similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases KLLA0E09021g 1 804915 806615 ON 5 E09021 (804915..806615) uniprot|Q8NJ22 Kluyveromyces lactis KLLA0E08987g frt1 Hexose transporter KLLA0E09043g 0 807159 809603 ON 5 E09043 complement(807159..809603) similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring mutant phenotype and genetic interactions suggest a role in cytokinesis KLLA0E09065g 0 810338 811468 ON 5 E09065 complement(810338..811468) highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase catalyzes the conversion of 5- enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate which is a precursor to aromatic amino acids KLLA0E09087g 1 812175 814343 ON 5 E09087 (812175..814343) similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup85p Nup120p Nup145p-C Sec13p and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis KLLA0E09109g 0 814476 815051 ON 5 E09109 complement(814476..815051) highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins KLLA0E09131g 0 815506 816633 ON 5 E09131 complement(815506..816633) similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 Protein of unknown function deletion causes hypersensitivity to the K1 killer toxin KLLA0E09153g 1 816861 817703 ON 5 E09153 (816861..817703) weakly similar to uniprot|Q07530 Saccharomyces cerevisiae YDL114W Hypothetical ORF KLLA0E09175g 0 817829 819739 ON 5 E09175 complement(817829..819739) similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway binds phosphatidylinositol-3-phosphate involved in localization of membranes to the preautophagosome potential Cdc28p substrate KLLA0E09197g 1 820095 824288 ON 5 E09197 (820095..824288) similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs KLLA0E09219g 0 824344 825138 ON 5 E09219 complement(824344..825138) similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Ribosomal RNA Processing Component of the exosome 3->5 exoribonuclease complex with Rrp4p Rrp41p Rrp43p and Dis3p (Rrp44p). KLLA0E09241g 0 825533 826306 ON 5 E09241 complement(825533..826306) weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C Hypothetical ORF KLLA0E09263g 0 827035 827517 ON 5 E09263 complement(827035..827517) similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C Hypothetical ORF KLLA0E09285g 1 828244 829518 ON 5 E09285 (828244..829518) similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor component of the U4/U6-U5 snRNP complex KLLA0E09307g 0 829846 830163 ON 5 E09307 complement(829846..830163) highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co- chaperonin that inhibits the ATPase activity of Hsp60p KLLA0E09329g 1 830886 831113 ON 5 E09329 (830886..831113) similar to uniprot|Q3E824 Saccharomyces cerevisiae YOR020W-A KLLA0E09351g 0 831306 831944 ON 5 E09351 complement(831306..831944) highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C KLLA0E09373g 0 832187 834076 ON 5 E09373 complement(832187..834076) similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Hypothetical ORF KLLA0E09395g 0 834365 835711 ON 5 E09395 complement(834365..835711) weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Ada Histone acetyltransferase complex component protein of the Ada histone acetyltransferase complex KLLA0E09417g 1 836226 836648 ON 5 E09417 (836226..836648) conserved hypothetical protein KLLA0E09439g 0 836948 837544 ON 5 E09439 complement(836948..837544) similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Ribosomal Like Protein 24 KLLA0E09461g 1 838259 838750 ON 5 E09461 (838259..838750) similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the mitochondrial import motor associated with the presequence translocase along with Ssc1p Tim44p Mge1p and Pam16p stimulates the ATPase activity of Ssc1p to drive mitochondrial import contains a J domain KLLA0E09483g 0 838945 839916 ON 5 E09483 complement(838945..839916) weakly similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential nuclear protein required for DNA repair forms a complex with Smc5p and Rhc18p KLLA0E09505g 1 840647 842554 ON 5 E09505 (840647..842554) weakly similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism dephosphorylated form is degraded by the ubiquitin-proteasome system potential Cdc28p substrate KLLA0E09527g 1 843133 845223 ON 5 E09527 (843133..845223) similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 beta-adaptin large subunit of the clathrin- associated protein complex KLLA0E09549g 0 845298 846224 ON 5 E09549 complement(845298..846224) similar to uniprot|Q07897 Saccharomyces cerevisiae YLR003C CMS1 Hypothetical ORF KLLA0E09571g 0 846600 848135 ON 5 E09571 complement(846600..848135) similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C Hypothetical ORF KLLA0E09593g 1 848785 851295 ON 5 E09593 (848785..851295) conserved hypothetical protein KLLA0E09615g 1 851587 853053 ON 5 E09615 (851587..853053) similar to uniprot|Q04673 YLR005W Saccharomyces cerevisiae SSL1 Component of RNA polymerase transcription factor TFIIH KLLA0E09637g 1 853845 855602 ON 5 E09637 (853845..855602) highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C Klac_5.trna7K 1 856274 856346 ON 5 tK-CUU (856274..856346) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 77.59 KLLA0E09681g 1 857611 859959 ON 5 E09681 (857611..859959) some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells binds to Aga1p during agglutination N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin C-terminal half is highly glycosylated and contains GPI anchor KLLA0E09703g 0 860245 861168 ON 5 E09703 complement(860245..861168) weakly similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p member vGLC.1420 KLLA0E09725g 1 861812 862447 ON 5 E09725 (861812..862447) no similarity KLLA0E09747g 1 862612 862887 ON 5 E09747 (862612..862887) similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A KLLA0E09769g 1 863295 865037 ON 5 E09769 (863295..865037) similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 third enzyme in the xylose pathway, Xylulokinase KLLA0E09791g 1 865604 866821 ON 5 E09791 (865604..866821) similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core KLLA0E09813g 1 867899 870139 ON 5 E09813 (867899..870139) similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1 3-mannosyltransferase integral membrane glycoprotein of the Golgi complex required for addition of alpha1 3-mannose linkages to N-linked and O- linked oligosaccharides one of five S. cerevisiae proteins of the MNN1 family KLLA0E09835g 0 870664 872172 ON 5 E09835 complement(870664..872172) highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase catalyzes the primary step of intracellular sulfate activation essential for assimilatory reduction of sulfate to sulfide involved in methionine metabolism KLLA0E09857g 0 872888 873694 ON 5 E09857 complement(872888..873694) weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP( )-dependent dehydrogenase acts on serine L-allo-threonine and other 3-hydroxy acids KLLA0E09879g 0 874102 875994 ON 5 E09879 complement(874102..875994) similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Hypothetical ORF KLLA0E09901g 0 877366 879048 ON 5 E09901 complement(877366..879048) some similarities with uniprot|P53729 Saccharomyces cerevisiae YNR029C Hypothetical ORF KLLA0E09923g 1 881665 883236 ON 5 E09923 (881665..883236) conserved hypothetical protein KLLA0E09945g 0 883778 884119 ON 5 E09945 complement(883778..884119) no similarity KLLA0E09967g 1 884414 885151 ON 5 E09967 (884414..885151) similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin hydrolyzes the peptide bond at the C-terminus of ubiquitin also the major processing enzyme for the ubiquitin-like protein Rub1p KLLA0E09989g 0 885282 887150 ON 5 E09989 complement(885282..887150) weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C Hypothetical ORF KLLA0E10011g 0 887535 888464 ON 5 E10011 complement(887535..888464) conserved hypothetical protein KLLA0E10033g 0 888721 889626 ON 5 E10033 complement(888721..889626) similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C Hypothetical ORF KLLA0E10055g 0 890157 891083 ON 5 E10055 complement(890157..891083) highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase involved in activation of Gln3p which is a transcription factor with a role in nitrogen utilization KLLA0E10077g 1 891885 892901 ON 5 E10077 (891885..892901) weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein KLLA0E10099g 0 893271 893972 ON 5 E10099 complement(893271..893972) highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein general transcription factor that interacts with other factors to form the preinitiation complex at promoters essential for viability KLLA0E10121g 1 894620 896509 ON 5 E10121 (894620..896509) similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4 KLLA0E10143g 0 896599 899229 ON 5 E10143 complement(896599..899229) similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Trehalose-6-phosphate phosphatase KLLA0E10165g 0 899751 900149 ON 5 E10165 complement(899751..900149) similar to gnl|GLV|CAGL0G05329g Candida glabrata CAGL0G05329g and some similarites with YDR073W uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 component of SWI/SNF global transcription activator complex KLLA0E10187g 1 901353 902957 ON 5 E10187 (901353..902957) similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase 1 involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) which is the most abundant sphingolipid in cells mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media KLLA0E10209g 0 903201 903455 ON 5 E10209 complement(903201..903455) similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay KLLA0E10231g 1 904368 904949 ON 5 E10231 (904368..904949) similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase acetylates polyamines such as putrescine spermidine and spermine may be involved in transcription initiation KLLA0E10253g 1 905780 906052 ON 5 E10253 (905780..906052) similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 The authentic, non-tagged protein was localized to the mitochondria KLLA0E10275g 1 906675 909065 ON 5 E10275 (906675..909065) similar to uniprot|P39944 Saccharomyces cerevisiae YER144C UBP5 Putative ubiquitin-specific protease that does not associate with the proteasome KLLA0E10297g 0 909140 910015 ON 5 E10297 complement(909140..910015) weakly similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm KLLA0E10319g 1 910343 911050 ON 5 E10319 (910343..911050) similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0E10341g 0 911148 912392 ON 5 E10341 complement(911148..912392) similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein contains a ubiquitin-associated (UBA) domain may act as a negative regulator of constitutive exocytosis may play a role in S-phase checkpoint control KLLA0E10363g 1 912583 913413 ON 5 E10363 (912583..913413) similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired KLLA0E10385g 0 913611 915095 ON 5 E10385 complement(913611..915095) similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A which is an essential prosthetic group for cytochrome c oxidase KLLA0E10407g 0 915551 918886 ON 5 E10407 complement(915551..918886) similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 Mitochondrial ATP-dependent protease involved in intramitochondrial proteolysis involved in degradation of misfolded proteins in mitochondria required for bigenesis and maintenance of mitochondria KLLA0E10429g 0 919489 920106 ON 5 E10429 complement(919489..920106) uniprot|P40914 Kluyveromyces lactis HAP3 Transcriptional activator HAP3 KLLA0E10451g 1 920415 922085 ON 5 E10451 (920415..922085) similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Flippase KLLA0E10473g 1 922357 923856 ON 5 E10473 (922357..923856) similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage homolog of human HAP1 and E. coli exoIII KLLA0E10495g 0 923922 924338 ON 5 E10495 complement(923922..924338) similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0E10517g 0 924701 929401 ON 5 E10517 complement(924701..929401) similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases cycles between the late-Golgi and prevacuolar endosome-like compartments KLLA0E10539g 1 929989 931104 ON 5 E10539 (929989..931104) highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated protein kinase involved in mating pheromone response activated by phosphorylation by Ste7p provides specificity during the mating vs. filamentous growth response by phosphorylating transcriptional and cytoplasmic targets KLLA0E10561g 1 932415 933986 ON 5 E10561 (932415..933986) highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Acetyl-coA hydrolase primarily localized to mitochondria required for acetate utilization and for diploid pseudohyphal growth KLLA0E10583g 0 934321 935421 ON 5 E10583 complement(934321..935421) similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase KLLA0E10605g 1 935625 936467 ON 5 E10605 (935625..936467) conserved hypothetical protein KLLA0E10627g 1 936850 937806 ON 5 E10627 (936850..937806) some similarities with uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the Mediator global transcriptional cofactor complex which is part of the RNA polymerase II holoenzyme and plays an essential role in basal and activated transcription direct target of the Cyc8p-Tup1p transcriptional corepressor KLLA0E10649g 1 938243 940372 ON 5 E10649 (938243..940372) highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 tryptophan synthetase KLLA0E10671g 1 940776 943364 ON 5 E10671 (940776..943364) weakly similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn7p and TATA- binding protein KLLA0E10693g 1 943825 946281 ON 5 E10693 (943825..946281) similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I involved in assembly of cell wall beta 1 6 glucan and asparagine- linked protein glycosylation ER type II integral membrane N-glycoprotein disruption leads to a K1 killer toxin- resistant phenotype KLLA0E10715g 1 947393 948907 ON 5 E10715 (947393..948907) some similarities with uniprot|P53189 Saccharomyces cerevisiae YGL028C KLLA0E10737g 0 949228 950184 ON 5 E10737 complement(949228..950184) conserved hypothetical protein Klac_5.trna8F 1 950420 950492 ON 5 tF-GAA (950420..950492) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 76.93 KLLA0E10781g 0 950629 950994 ON 5 E10781 complement(950629..950994) similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Coiled-coil protein that may contribute to compartmentalization of nucleolar constituents expression is growth-regulated KLLA0E10803g 1 951335 953896 ON 5 E10803 (951335..953896) similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C Hypothetical ORF KLLA0E10825g 0 954084 955310 ON 5 E10825 complement(954084..955310) similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Hypothetical ORF KLLA0E10847g 0 955703 956256 ON 5 E10847 complement(955703..956017,956254..956256) highly similar to uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit KLLA0E10869g 1 957487 957954 ON 5 E10869 (957487..957954) similar to uniprot|P04449 Saccharomyces cerevisiae YGL031C RPL24A and to uniprot|P24000 Saccharomyces cerevisiae YGR148C RPL24B KLLA0E10891g 1 958672 958944 ON 5 E10891 (958672..958944) conserved hypothetical protein KLLA0E10913g 1 959536 960201 ON 5 E10913 (959536..960201) similar to gnl|GLV|CAGL0E03003g Candida glabrata CAGL0E03003g and weakly similar to YGR147C uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 N alpha-acetyl- transferase transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins KLLA0E10935g 0 960404 961330 ON 5 E10935 complement(960404..961330) similar to uniprot|P78609 Pichia jadinii Uricase Klac_YGOB_Anc_4.81 0 962029 962289 ON 5 Anc_4.81 complement(962029..962289) ANNOTATED BY YGOB - KLLA0E11001g 0 964114 965010 ON 5 E11001 complement(964114..965010) conserved hypothetical protein KLLA0E11023g 1 966805 968229 ON 5 E11023 (966805..968229) uniprot|P50898 Kluyveromyces lactis MIG1 Regulatory protein MIG1 KLLA0E11045g 1 968674 969972 ON 5 E11045 (968674..969972) similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling KLLA0E11067g 0 969999 974819 ON 5 E11067 complement(969999..974819) similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC) KLLA0E11089g 0 975074 975967 ON 5 E11089 complement(975074..975967) similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate KLLA0E11111g 0 976184 978910 ON 5 E11111 complement(976184..978910) similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Overexpression rescues sro7/sop1 in NaCl. Encodes a membrane protein. KLLA0E11133g 1 979660 981042 ON 5 E11133 (979660..981042) some similarities with uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF KLLA0E11155g 1 981392 982696 ON 5 E11155 (981392..982696) some similarities with uniprot|Q03508 Saccharomyces cerevisiae YMR265C Hypothetical ORF KLLA0E11177g 1 983669 985150 ON 5 E11177 (983669..985150) similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA required for building functional kinetochores conserved from yeast to humans KLLA0E11199g 0 985522 986178 ON 5 E11199 complement(985522..986178) similar to uniprot|P38428 Saccharomyces cerevisiae YMR264W CUE1 Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination KLLA0E11221g 0 986623 987123 ON 5 E11221 complement(986623..987123) similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex along with Rpd3p and Sin3p that is involved in silencing at telomeres rDNA and silent mating-type loci KLLA0E11243g 0 987351 988325 ON 5 E11243 complement(987351..988325) similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Hypothetical ORF KLLA0E11265g 1 988846 992292 ON 5 E11265 (988846..992292) similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C TPS3 115 kD regulatory subunit of trehalose-6- phosphate synthase/phosphatase complex KLLA0E11287g 1 992638 993105 ON 5 E11287 (992638..993105) highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A KLLA0E11309g 0 993416 994498 ON 5 E11309 complement(993416..994498) conserved hypothetical protein KLLA0E11331g 0 994770 996308 ON 5 E11331 complement(994770..996308) similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 Sir4p-Interacting Factor 535 amino acid protein containing 4 WD-40 repeats and a nuclear localization signal KLLA0E11353g 1 996736 998898 ON 5 E11353 (996736..998898) similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis KLLA0E11375g 1 999242 1000111 ON 5 E11375 (999242..1000111) similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor cytosolic homolog of Sls1p which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum KLLA0E11397g 0 1000253 1002325 ON 5 E11397 complement(1000253..1002325) weakly similar to uniprot|P38257 Saccharomyces cerevisiae YBR098W MMS4 Protein involved in recombination and DNA repair; subunit of a structure-specific Mms4-Mus81 endonuclease that cleaves branched DNA KLLA0E11419g 0 1002637 1005693 ON 5 E11419 complement(1002637..1005693) similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis KLLA0E11441g 0 1006025 1006891 ON 5 E11441 complement(1006025..1006891) weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex KLLA0E11485g 1 1008460 1010949 ON 5 E11485 (1008460..1010949) similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C KLLA0E11507g 1 1011380 1014337 ON 5 E11507 (1011380..1014337) similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome may participate in the recognition of several ligands of the proteasome contains a leucine-rich repeat (LRR) domain a site for protein? protein interactions KLLA0E11529g 0 1014620 1015363 ON 5 E11529 complement(1014620..1015363) similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W PPA1 Subunit c'' of the vacuolar ATPase which functions in acidification of the vacuole KLLA0E11551g 0 1015657 1016739 ON 5 E11551 complement(1015657..1016739) highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 homoserine kinase KLLA0E11573g 1 1017355 1018833 ON 5 E11573 (1017355..1018833) similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins KLLA0E11595g 0 1018972 1024518 ON 5 E11595 complement(1018972..1024518) similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain required for wild- type cytokinesis and cell separation localizes to the actomyosin ring binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively KLLA0E11617g 1 1025228 1027183 ON 5 E11617 (1025228..1027183) conserved hypothetical protein KLLA0E11639g 1 1028781 1029998 ON 5 E11639 (1028781..1029998) similar to uniprot|Q75C51 Ashbya gossypii ACR066C ACR066Cp and weakly similar to YOR101W uniprot|P01119 Saccharomyces cerevisiae YOR101W RAS1 GTPase involved in G- protein signaling in the adenylate cyclase activating pathway plays a role in cell proliferation localized to the plasma membrane homolog of mammalian RAS proto- oncogenes KLLA0E11661g 1 1030674 1031523 ON 5 E11661 (1030674..1030676,1031278..1031523) highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021c RPS27B ribosomal protein and to uniprot|P35997 Saccharomyces cerevisiae YKL156w RPS27A, Protein component of the small (40S) ribosomal subunit KLLA0E11683g 0 1031875 1034064 ON 5 E11683 complement(1031875..1034064) similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit KLLA0E11705g 1 1034361 1035134 ON 5 E11705 (1034361..1035134) similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit involved in SRP-dependent protein targeting anchors Srp101p to the ER membrane. KLLA0E11727g 0 1035282 1035527 ON 5 E11727 complement(1035282..1035527) similar to uniprot|Q2V2P5 Saccharomyces cerevisiae YIL102C-A Klac_5.trna9R 1 1035777 1035848 ON 5 tR-UCU (1035777..1035848) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 KLLA0E11771g 1 1036220 1041166 ON 5 E11771 (1036220..1041166) similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC) localizes to the nuclear periphery of nuclear pores homologous to human p205 KLLA0E11793g 0 1041272 1043614 ON 5 E11793 complement(1041272..1043614) weakly similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex which mediates nuclear import and export KLLA0E11815g 0 1044591 1048385 ON 5 E11815 complement(1044591..1048385) similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase KLLA0E11837g 1 1049076 1049996 ON 5 E11837 (1049076..1049996) some similarities with uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member Ypt6p involved in vesicle mediated protein transport KLLA0E11859g 0 1050114 1050857 ON 5 E11859 complement(1050114..1050857) highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase of the glycolytic pathway converts 3-phosphoglycerate to 2- phosphoglycerate KLLA0E11881g 1 1052911 1053744 ON 5 E11881 (1052911..1053744) similar to uniprot|P25613 Saccharomyces cerevisiae YCR010C ADY2 Accumulation of DYads member of the TC 9.B.33 YaaH family of putative transporters Protein involved in Accumulation of DYads or uniprot|P32907 Saccharomyces cerevisiae YNR002c KLLA0E11903g 1 1054430 1055230 ON 5 E11903 (1054430..1055230) highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 BAR adaptor protein subunit of a complex (Rvs161p Rvs167p) that regulates actin endocytosis and viability following starvation or osmotic stress KLLA0E11925g 1 1055838 1059566 ON 5 E11925 (1055838..1059566) conserved hypothetical protein KLLA0E11947g 0 1060048 1061892 ON 5 E11947 complement(1060048..1061892) similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W Klac_5.trna10N 0 1062391 1062464 ON 5 tN-GUU complement(1062391..1062464) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 Klac_5.trna11D 1 1062834 1062905 ON 5 tD-GUC (1062834..1062905) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 KLLA0E12013g 0 1063096 1065534 ON 5 E12013 complement(1063096..1065534) similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W KLLA0E12035g 1 1066171 1067778 ON 5 E12035 (1066171..1067778) conserved hypothetical protein KLLA0E12057g 1 1068487 1074933 ON 5 E12057 (1068487..1074933) similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM3 Protein involved in assembly of proteasomal core particles in the nucleus required for normal resistance to bleomycin may be involved in protection against oxidative damage KLLA0E12079g 1 1075299 1075943 ON 5 E12079 (1075299..1075943) highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Secretory vesicle-associated Rab GTPase essential for exocytosis associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane KLLA0E12101g 1 1076424 1078949 ON 5 E12101 (1076424..1078949) similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W VTC2 and similar to uniprot|Q02725 Saccharomyces cerevisiae YPL019C VTC3 Vacuolar membrane proteins KLLA0E12123g 1 1079451 1079996 ON 5 E12123 (1079451..1079996) similar to uniprot|P33421 Saccharomyces cerevisiae YKL141W SDH3 Cytochrome b subunit of succinate dehydrogenase (Sdh1p Sdh2p Sdh3p Sdh4p) which couples the oxidation of succinate to the transfer of electrons to ubiquinone and some similarites with YMR118C uniprot|Q04487 Saccharomyces cerevisiae YMR118C Hypothetical ORF, member of GLR.231 KLLA0E12145g 1 1080245 1081612 ON 5 E12145 (1080245..1081612) similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) which phosphorylates the C- terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing KLLA0E12167g 0 1081741 1081935 ON 5 E12167 complement(1081741..1081935) similar to uniprot|P69852 Saccharomyces cerevisiae YKL138C-A KLLA0E12189g 1 1082163 1082732 ON 5 E12189 (1082163..1082732) similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering KLLA0E12211g 0 1082810 1083199 ON 5 E12211 complement(1082810..1083199) similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit KLLA0E12233g 1 1083537 1083848 ON 5 E12233 (1083537..1083848) similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W Hypothetical ORF KLLA0E12255g 0 1084026 1086128 ON 5 E12255 complement(1084026..1086128) similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin large subunit of the clathrin- associated protein (AP-1) complex KLLA0E12277g 1 1086778 1088158 ON 5 E12277 (1086778..1087329,1087730..1088158) highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 WD repeat protein (G-beta like protein) involved in translation regulation required for repression of Gcn4p activity in the absence of amino-acid starvation core component of the ribosome ortholog of mammalian RACK1 KLLA0E12321g 1 1088810 1089961 ON 5 E12321 (1088810..1089961) similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W KLLA0E12343g 1 1090766 1091761 ON 5 E12343 (1090766..1091761) weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Cytoskeletal protein of unknown function overexpression causes growth arrest KLLA0E12365g 0 1092303 1093220 ON 5 E12365 complement(1092303..1093220) highly similar to uniprot|P18239 Saccharomyces cerevisiae YBL030C PET9 Major ADP/ATP carrier of the mitochondrial inner membrane exchanges cytosolic ADP for mitochondrially synthesized ATP Pet9p and Sal1p have an overlapping function critical for viability KLLA0E12387g 0 1094372 1094647 ON 5 E12387 complement(1094372..1094647) similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A KLLA0E12409g 1 1095828 1096724 ON 5 E12409 (1095828..1096724) some similarities with uniprot|P38201 Saccharomyces cerevisiae YBL029W Hypothetical ORF KLLA0E12431g 0 1097009 1097359 ON 5 E12431 complement(1097009..1097359) similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C KLLA0E12453g 1 1098094 1099109 ON 5 E12453 (1098094..1098095,1098542..1099109) highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A RPL19A and to uniprot|P05735 Saccharomyces cerevisiae YBL027W RPL19B Proteins component of the large (60S) ribosomal subunit Klac_YGOB_YBL026W-A 0 1099583 1099819 ON 5 YBL026W-A complement(1099583..1099819) ANNOTATED BY YGOB - KLLA0E12475g 0 1100281 1103196 ON 5 E12475 complement(1100281..1103196) highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase involved in interconversion between different oxidation states of tetrahydrofolate (THF) provides activities of formyl-THF synthetase methenyl-THF cyclohydrolase and methylene-THF dehydrogenase KLLA0E12497g 0 1103583 1105457 ON 5 E12497 complement(1103583..1105457) weakly similar to uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 transcription factor of the TEA/ATTS DNA-binding domain family regulator of Ty1 expression KLLA0E12519g 0 1107848 1110868 ON 5 E12519 complement(1107848..1110868) similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Protein required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre- ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein KLLA0E12541g 0 1112440 1113630 ON 5 E12541 complement(1112440..1113630) some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C KLLA0E12563g 1 1117022 1117741 ON 5 E12563 (1117022..1117068,1117342..1117741) highly similar to uniprot|P15731 Saccharomyces cerevisiae YBR082C UBC4 Ubiquitin-conjugating enzyme that mediates degradation of short-lived and abnormal proteins interacts with E3-CaM in ubiquitinating calmodulin interacts with many SCF ubiquitin protein ligases component of the cellular stress response KLLA0E12585g 1 1118642 1122544 ON 5 E12585 (1118642..1122544) similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex involved in proper assembly of the complex also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex KLLA0E12607g 0 1122747 1124120 ON 5 E12607 complement(1122747..1124120) some similarities with uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 Glycoprotein of the ER membrane involved in ER-to-Golgi transport of glycosylphosphatidylinositol (GPI)-anchored proteins KLLA0E12629g 1 1124393 1124965 ON 5 E12629 (1124393..1124965) weakly similar to uniprot|Q12025 Saccharomyces cerevisiae YDR056C Hypothetical ORF KLLA0E12651g 1 1125573 1126388 ON 5 E12651 (1125573..1126388) similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis required for respiratory growth and for normal mitochondrial morphology KLLA0E12673g 0 1126397 1127197 ON 5 E12673 complement(1126397..1127197) weakly similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1 3 4 5 6- pentakisphosphate 2-kinase nuclear protein required for synthesis of 1 2 3 4 5 6-hexakisphosphate (phytate) which is integral to cell function has 2 motifs conserved in other fungi ipk1 gle1 double mutant is inviable KLLA0E12695g 1 1127497 1128636 ON 5 E12695 (1127497..1128636) highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase catalyzes formation of deoxyhypusine the first step in hypusine biosynthesis triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels tetrameric KLLA0E12717g 1 1128947 1130287 ON 5 E12717 (1128947..1130287) similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane KLLA0E12739g 0 1130385 1131698 ON 5 E12739 complement(1130385..1131698) similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Ribosomal RNA Processing 3->5 exoribonuclease Component of the exosome 3->5 exonuclease complex with Rrp41p Rrp42p Rrp43p and Dis3p (Rrp44p). KLLA0E12761g 1 1131727 1133235 ON 5 E12761 (1131727..1133235) similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting highly conserved across Archaea Bacteria and Eukarya KLLA0E12783g 1 1134308 1134970 ON 5 E12783 (1134308..1134970) some similarities with uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin interacts with Pho85p cyclin-dependent kinase (Cdk) induced by Gcn4p at level of transcription specifically required for Gcn4p degradation may be sensor of cellular protein biosynthetic capacity KLLA0E12805g 1 1135181 1135780 ON 5 E12805 (1135181..1135780) similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor KLLA0E12827g 1 1136272 1137957 ON 5 E12827 (1136272..1137957) similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible alkaline phosphatase a glycoprotein localized to the vacuole regulated by levels of inorganic phosphate and by a system consisting of Pho4p Pho9p Pho80p Pho81p and Pho85p dephosphorylates phosphotyrosyl peptides KLLA0E12849g 0 1138282 1139460 ON 5 E12849 complement(1138282..1139460) highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p Mnn10p Mnn11p and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation KLLA0E12871g 1 1139990 1140373 ON 5 E12871 (1139990..1140373) weakly similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear transport depletion alters nucleoporin distribution and nuclear envelope morphology suggesting a role in the spatial organization of nuclear pores KLLA0E12893g 0 1140409 1141563 ON 5 E12893 complement(1140409..1141563) similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing KLLA0E12915g 0 1142167 1144131 ON 5 E12915 complement(1142167..1144131) similar to uniprot|P32901 Saccharomyces cerevisiae YKR093W PTR2 Functions in transport of small peptides into the cell Peptide transporter KLLA0E12937g 1 1145337 1145960 ON 5 E12937 (1145337..1145960) no similarity KLLA0E12959g 0 1146299 1148038 ON 5 E12959 complement(1146299..1148038) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane Klac_YGOB_MFA1 0 1149528 1149629 ON 5 MFA1 complement(1149528..1149629) ANNOTATED BY YGOB - similar to Scer MFA1 pheromone KLLA0E12981g 0 1150659 1151585 ON 5 E12981 complement(1150659..1151585) similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase also known as pantoate- beta-alanine ligase required for pantothenic acid biosynthesis deletion causes pantothenic acid auxotrophy homologous to E. coli panC KLLA0E13003g 1 1151967 1153988 ON 5 E13003 (1151967..1153988) similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p) conserved coiled-coil protein involved in chromosome segregation spindle checkpoint activity kinetochore assembly and clustering KLLA0E13025g 0 1154244 1156820 ON 5 E13025 complement(1154244..1156820) highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2 KLLA0E13047g 1 1157346 1158452 ON 5 E13047 (1157346..1158452) some similarities with uniprot|P32583 Saccharomyces cerevisiae YKR092C SRP40 Suppressor of mutant AC40 subunit of RNA polymerase I and III nucleolar protein that is immunologically and structurally related to rat Nopp140 a nonribosomal protein of the nucleolus and coiled bodies KLLA0E13069g 1 1159034 1159282 ON 5 E13069 (1159034..1159282) conserved hypothetical protein KLLA0E13091g 0 1159382 1160473 ON 5 E13091 complement(1159382..1160473) similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W Putative lipase of the peroxisomal matrix transcriptionally activated by Yrm1p along with genes involved in multidrug resistance KLLA0E13113g 0 1161001 1162113 ON 5 E13113 complement(1161001..1162113) weakly similar to uniprot|Q12416 Saccharomyces cerevisiae YOR083W WHI5 Protein that regulates the critical cell size required for passage through Start and commitment to cell division; may act upstream of SCB binding factor (SBF) and MCB binding factor (MBF); periodically expressed in G1 KLLA0E13135g 0 1162722 1164599 ON 5 E13135 complement(1162722..1164599) weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth KLLA0E13157g 1 1165197 1166450 ON 5 E13157 (1165197..1166450) similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 catalyzes formation of Psi55 (modified uridine) in mitochondrial and cytoplasmic tRNAs Pseudouridine synthase KLLA0E13179g 0 1166544 1168196 ON 5 E13179 complement(1166544..1168196) similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral plasma membrane protein KLLA0E13201g 1 1168489 1169478 ON 5 E13201 (1168489..1169478) highly similar to uniprot|P38629 YNL290W Saccharomyces cerevisiae RFC3 Subunit of heteropentameric Replication factor C (RF-C) KLLA0E13223g 1 1170139 1170987 ON 5 E13223 (1170139..1170987) similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Pho85 cyclin of the Pcl1 2-like subfamily involved in entry into the mitotic cell cycle and regulation of morphogenesis localizes to sites of polarized cell growth KLLA0E13267g 1 1172956 1174221 ON 5 E13267 (1172956..1174221) similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4- NOT complex involved in controlling mRNA initiation elongation and degradation binds Cdc39p KLLA0E13289g 1 1174507 1177341 ON 5 E13289 (1174507..1177341) similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo KLLA0E13311g 1 1177801 1178322 ON 5 E13311 (1177801..1178322) similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Putative homolog of human NPC2/He1 which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes KLLA0E13333g 1 1178639 1179130 ON 5 E13333 (1178639..1179130) highly similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1 also required for sporulation KLLA0E13355g 1 1179450 1179737 ON 5 E13355 (1179450..1179737) similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit KLLA0E13377g 0 1179884 1180828 ON 5 E13377 complement(1179884..1180828) similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase performs the second step in synthesis of FAD from riboflavin KLLA0E13399g 0 1181159 1182277 ON 5 E13399 complement(1181159..1182277) some similarities with uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription KLLA0E13421g 0 1182524 1184344 ON 5 E13421 complement(1182524..1184344) similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm and bud neck potential Cdc28p substrate KLLA0E13443g 0 1184806 1187526 ON 5 E13443 complement(1184806..1187526) similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial transporter acts both as a glutamate uniporter and as an aspartate-glutamate exchanger involved in nitrogen metabolism ornithine synthesis and the malate-aspartate NADH shuttle KLLA0E13465g 0 1188323 1190527 ON 5 E13465 complement(1188323..1190527) weakly similar to uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF KLLA0E13487g 0 1190615 1191307 ON 5 E13487 complement(1190615..1191307) some similarities with uniprot|Q12139 Saccharomyces cerevisiae YPR022C Hypothetical ORF KLLA0E13509g 0 1191602 1192678 ON 5 E13509 complement(1191602..1192678) similar to uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor nonessential component of the NuA4 acetyltransferase complex homologous to Drosophila dosage compensation protein MSL3 KLLA0E13531g 1 1193481 1194902 ON 5 E13531 (1193481..1194902) some similarities with uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 plasma membrane-bound casein kinase I homolog KLLA0E13553g 0 1195444 1197186 ON 5 E13553 complement(1195444..1197186) weakly similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein may participate in pathways regulating cell wall metabolism deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall KLLA0E13575g 1 1198133 1200592 ON 5 E13575 (1198133..1200592) highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation plays a role in heat shock element (HSE)-mediated gene expression and multivesicular body sorting contains a hect (homologous to E6-AP carboxyl terminus) domain KLLA0E13597g 0 1201715 1204183 ON 5 E13597 complement(1201715..1204183) weakly similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Protein that specifically binds to mRNAs encoding chromatin modifiers and spindle pole body components has roles in longevity in maintenance of cell wall integrity and in sensitivity to and recovery from pheromone arrest KLLA0E13619g 0 1205834 1206619 ON 5 E13619 complement(1205834..1206619) highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis KLLA0E13641g 1 1206847 1208034 ON 5 E13641 (1206847..1208034) similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA depletion leads to inhibited pre-rRNA processing and reduced polysome levels localizes primarily to the nucleolus KLLA0E13663g 1 1208328 1208945 ON 5 E13663 (1208328..1208945) similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Hypothetical ORF KLLA0E13685g 1 1209218 1211224 ON 5 E13685 (1209218..1211224) highly similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C Protein required for cell viability KLLA0E13707g 0 1211389 1212045 ON 5 E13707 complement(1211389..1212045) similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W KLLA0E13729g 0 1212409 1213860 ON 5 E13729 complement(1212409..1213860) similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Protein required for growth at low temperature KLLA0E13751g 1 1214440 1215072 ON 5 E13751 (1214440..1215072) highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25 KLLA0E13773g 0 1215253 1216680 ON 5 E13773 complement(1215253..1216680) highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for optimal CDC20 transcription interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p KLLA0E13795g 0 1216938 1218659 ON 5 E13795 complement(1216938..1218659) similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter exports large neutral amino acids from the vacuole member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA- glycine transporters KLLA0E13817g 1 1219430 1222099 ON 5 E13817 (1219430..1222099) highly similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway has 3- hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities KLLA0E13839g 0 1222491 1222993 ON 5 E13839 complement(1222491..1222718,1222985..1222993) similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex KLLA0E13861g 0 1223289 1224539 ON 5 E13861 complement(1223289..1224539) similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family KLLA0E13883g 0 1225727 1230157 ON 5 E13883 complement(1225727..1230157) no similarity KLLA0E13905g 1 1231826 1233544 ON 5 E13905 (1231826..1233544) similar to uniprot|Q12031 Saccharomyces cerevisiae YPR006C ICL2 2-methylisocitrate lyase of the mitochondrial matrix functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate ICL2 transcription is repressed by glucose and induced by ethanol KLLA0E13927g 1 1234293 1235291 ON 5 E13927 (1234293..1235291) no similarity KLLA0E13949g 1 1236690 1238051 ON 5 E13949 (1236690..1238051) no similarity KLLA0E13971g 0 1238160 1239221 ON 5 E13971 complement(1238160..1239221) similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W Hypothetical ORF KLLA0E13993g 0 1239566 1241602 ON 5 E13993 complement(1239566..1241602) some similarities with uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain positively regulates transcription of genes involved in uracil biosynthesis activity may be modulated by interaction with Tup1p KLLA0E14015g 1 1242786 1243832 ON 5 E14015 (1242786..1243832) similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF KLLA0E14037g 1 1244141 1245166 ON 5 E14037 (1244141..1245166) similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C Hypothetical ORF KLLA0E14059g 1 1245694 1247814 ON 5 E14059 (1245694..1247814) similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Hypothetical ORF Klac_5.trna12F 1 1248065 1248137 ON 5 tF-GAA (1248065..1248137) tRNA Type: Phe (F) | Anti-Codon: GAA | Cove Score: 76.93 KLLA0E14103g 0 1248332 1249927 ON 5 E14103 complement(1248332..1249927) similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Hypothetical ORF KLLA0E14125g 1 1250334 1251767 ON 5 E14125 (1250334..1251767) similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing required for assembly of U4 snRNA into the U4/U6 particle KLLA0E14147g 0 1251880 1252815 ON 5 E14147 complement(1251880..1252815) highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid couples the deubiquitination and degradation of proteasome substrates KLLA0E14169g 1 1253498 1253965 ON 5 E14169 (1253498..1253965) weakly similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p which is involved in regulation of a variety of metabolic processes overproduction causes decreased cellular content of glycogen KLLA0E14191g 0 1254213 1256795 ON 5 E14191 complement(1254213..1256795) similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex required for nuclear pore formation forms a subcomplex with Nsp1p Nup57p and Nup49p KLLA0E14213g 0 1257304 1258902 ON 5 E14213 complement(1257304..1258902) highly similar to uniprot|Q12428 Saccharomyces cerevisiae YPR002W PDH1 Mitochondrial protein that participates in respiration induced by diauxic shift homologous to E. coli PrpD may take part in the conversion of 2-methylcitrate to 2-methylisocitrate KLLA0E14235g 0 1260247 1261668 ON 5 E14235 complement(1260247..1261668) highly similar to uniprot|P43635 Saccharomyces cerevisiae YPR001W CIT3 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate mitochondrial isozyme involved in the TCA cycle KLLA0E14257g 0 1262619 1263242 ON 5 E14257 complement(1262619..1263242) similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA binds double-stranded RNA in vitro Klac_CEN5 1 1263806 1264001 ON 5 CEN5 (1263806..1264001) Chromosome V centromere KLLA0E14301g 0 1264866 1266038 ON 5 E14301 complement(1264866..1266038) similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4 involved in telomeric silencing and DNA double- strand break repair KLLA0E14323g 1 1266372 1267070 ON 5 E14323 (1266372..1267070) highly similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex which is involved in ubiquitin-dependent sorting of proteins into the endosome appears to be functionally related to SNF7 involved in glucose derepression KLLA0E14345g 0 1267186 1268520 ON 5 E14345 complement(1267186..1268520) similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 Non-essential tRNA:pseudouridine synthase introduces pseudouridines at position 38 or 39 in tRNA important for maintenance of translation efficiency and normal cell growth localizes to both the nucleus and cytoplasm KLLA0E14367g 1 1268901 1270691 ON 5 E14367 (1268901..1270691) similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 involved in the maturation of 25S ribosomal RNA ATP-dependent RNA helicase KLLA0E14389g 0 1270718 1272154 ON 5 E14389 complement(1270718..1272154) weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation) which may play a role in protein degradation KLLA0E14411g 1 1272947 1273903 ON 5 E14411 (1272947..1273903) highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Pil1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p KLLA0E14433g 0 1274502 1275650 ON 5 E14433 complement(1274502..1275650) similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha- ketoglutarate dioxygenase KLLA0E14477g 0 1281791 1283941 ON 5 E14477 complement(1281791..1283941) weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381w FRE3 protein Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters KLLA0E14499g 1 1286923 1288563 ON 5 E14499 (1286923..1288563) similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane KLLA0E14543g 0 1290917 1294591 ON 5 E14543 complement(1290917..1294591) some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W KLLA0E14587g 0 1297636 1300884 ON 5 E14587 complement(1297636..1300884) similar to uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump involved in Na efflux to allow salt tolerance likely not involved in Li efflux KLLA0E14609g 1 1302073 1303992 ON 5 E14609 (1302073..1303992) similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter member of the ARN family of transporters that specifically recognize siderophore-iron chelates responsible for uptake of iron bound to ferrirubin ferrirhodin and related siderophores KLLA0E14631g 0 1304707 1307244 ON 5 E14631 complement(1304707..1307244) highly similar to uniprot|P07337 Kluyveromyces marxianus Beta-glucosidase precursor KLLA0E14653g 1 1309427 1310860 ON 5 E14653 (1309427..1310860) weakly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C HXT3 Low affinity glucose transporter of the major facilitator superfamily KLLA0E14675g 1 1312581 1314302 ON 5 E14675 (1312581..1314302) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane KLLA0E14697g 0 1316238 1318958 ON 5 E14697 complement(1316238..1318958) similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W KLLA0E14719g 1 1319163 1320968 ON 5 E14719 (1319163..1320968) similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis putative alpha 1 2 mannosyltransferase required for addition of the third mannose onto the GPI core structure human PIG-Bp is a functional homolog KLLA0E14741g 0 1321041 1322180 ON 5 E14741 complement(1321041..1322180) similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix required for export of C-terminal tail of Cox2p through the inner membrane KLLA0E14763g 1 1322461 1323663 ON 5 E14763 (1322461..1323663) conserved hypothetical protein KLLA0E14785g 0 1323743 1324675 ON 5 E14785 complement(1323743..1324675) highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase subunit of the transcription factor TFIIH involved in transcription initiation at RNA polymerase II promoters KLLA0E14807g 1 1324910 1326100 ON 5 E14807 (1324910..1326100) similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial polypeptide chain release factor involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation lack of MRF1 causes mitochondrial genome instability KLLA0E14829g 1 1326334 1328367 ON 5 E14829 (1326334..1328367) similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C ROG1 Protein with putative serine active lipase domain and similar to uniprot|Q12451 Saccharomyces cerevisiae YDL109C OSH2 oxysterol-binding proteins KLLA0E14851g 0 1328372 1330381 ON 5 E14851 complement(1328372..1330381) similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 transport protein that interacts with Sec20p required for protein transport from the endoplasmic reticulum to the golgi apparatus Klac_5.trna13A 1 1330784 1330856 ON 5 tA-AGC (1330784..1330856) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0E14895g 0 1331095 1331928 ON 5 E14895 complement(1331095..1331928) some similarities with uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor involved in chromatin assembly after DNA replication anti- silencing protein that causes derepression of silent loci when overexpressed KLLA0E14917g 0 1332378 1333469 ON 5 E14917 complement(1332378..1333469) conserved hypothetical protein KLLA0E14939g 1 1334635 1335831 ON 5 E14939 (1334635..1335831) some similarities with uniprot|P36135 Saccharomyces cerevisiae YKR042W UTH1 Youth involved in determining yeast longevity involved in cell growth KLLA0E14961g 0 1336543 1337358 ON 5 E14961 complement(1336543..1337358) highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Hypothetical ORF KLLA0E14983g 0 1337771 1338658 ON 5 E14983 complement(1337771..1338658) similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Protein specifically required for packaging of the high-affinity phosphate transporter Pho84p into COPII coated vesicles for transport to the plasma membrane transcription and localization are regulated by phosphate levels KLLA0E15005g 0 1339324 1341024 ON 5 E15005 complement(1339324..1341024) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions KLLA0E15027g 0 1341521 1342381 ON 5 E15027 complement(1341521..1342381) weakly similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange KLLA0E15049g 0 1343243 1344496 ON 5 E15049 complement(1343243..1344496) similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p required for the regulation of microtubule dynamics during mitosis controls bud morphogenesis involved in the transport of H2A and H2B histones to the nucleus KLLA0E15071g 1 1345080 1345793 ON 5 E15071 (1345080..1345793) highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-Phosphate 3- epimerase KLLA0E15093g 0 1345930 1346412 ON 5 E15093 complement(1345930..1346412) similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W Hypothetical ORF KLLA0E15115g 1 1347073 1348281 ON 5 E15115 (1347073..1348281) weakly similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C Hypothetical ORF KLLA0E15137g 0 1348350 1348739 ON 5 E15137 complement(1348350..1348739) similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 The authentic non-tagged protein was localized to the mitochondria KLLA0E15159g 1 1349357 1349896 ON 5 E15159 (1349357..1349896) similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Component of small nuclear ribonucleoprotein complexes involved in mRNA decapping and decay KLLA0E15181g 0 1350236 1351633 ON 5 E15181 complement(1350236..1351633) conserved hypothetical protein KLLA0E15203g 1 1353232 1354857 ON 5 E15203 (1353232..1354857) conserved hypothetical protein KLLA0E15225g 1 1355166 1356389 ON 5 E15225 (1355166..1356389) highly similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1- methyladenosine) methyltransferase with Gcd10p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression KLLA0E15247g 0 1356442 1357350 ON 5 E15247 complement(1356442..1357350) similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W KLLA0E15269g 1 1357782 1359470 ON 5 E15269 (1357782..1359470) similar to uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase required for transcriptional regulation at core promoters functions at or near the TATA box KLLA0E15291g 0 1359509 1361590 ON 5 E15291 complement(1359509..1361590) conserved hypothetical protein Klac_YGOB_Anc_1.226 1 1361839 1361991 ON 5 Anc_1.226 (1361839..1361991) ANNOTATED BY YGOB - KLLA0E15313g 1 1362851 1365025 ON 5 E15313 (1362851..1365025) similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway activated under severe osmotic stress KLLA0E15335g 1 1365717 1368926 ON 5 E15335 (1365717..1368926) uniprot|Q9Y7B9 Kluyveromyces lactis trk1 Potassium transporter KLLA0E15357g 1 1370741 1377427 ON 5 E15357 (1370741..1377427) highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Multifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase) that catalyzes the two first reactions of the pyrimidine pathway; carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase KLLA0E15379g 1 1378099 1379142 ON 5 E15379 (1378099..1379142) weakly similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C Hypothetical ORF KLLA0E15401g 0 1379248 1381383 ON 5 E15401 complement(1379248..1381383) similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Hypothetical ORF KLLA0E15423g 1 1381552 1382835 ON 5 E15423 (1381552..1382835) similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Hypothetical ORF KLLA0E15445g 0 1383230 1384210 ON 5 E15445 complement(1383230..1384210) similar to uniprot|P23500 YKR052C Saccharomyces cerevisiae YKR052C MRS4 Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low- iron conditions; may transport other cations in addition to iron KLLA0E15467g 1 1385802 1386722 ON 5 E15467 (1385802..1386722) weakly similar to uniprot|P50091 Saccharomyces cerevisiae YGR239C PEX21 protein Part of a two-member peroxin family KLLA0E15489g 0 1386926 1388254 ON 5 E15489 complement(1386926..1388254) weakly similar to uniprot|P38854 Saccharomyces cerevisiae YHR159W KLLA0E15511g 1 1388626 1391343 ON 5 E15511 (1388626..1391343) similar to uniprot|P50090 Saccharomyces cerevisiae YGR238C KEL2 Protein that functions in a complex with Kel1p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate AND similar to YHR158C uniprot|P38853 Saccharomyces cerevisiae YHR158C KEL1 Protein required for proper cell fusion and cell morphology functions in a complex with Kel2p to negatively regulate mitotic exit interacts with Tem1p and Lte1p localizes to regions of polarized growth potential Cdc28p substrate KLLA0E15533g 0 1391524 1391976 ON 5 E15533 complement(1391524..1391976) no similarity KLLA0E15555g 1 1393066 1395366 ON 5 E15555 (1393066..1395366) some similarities with uniprot|P50089 Saccharomyces cerevisiae YGR237C Hypothetical ORF KLLA0E15577g 1 1396270 1396581 ON 5 E15577 (1396270..1396581) conserved hypothetical protein KLLA0E15599g 1 1397094 1397786 ON 5 E15599 (1397094..1397786) similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Hypothetical ORF KLLA0E15621g 0 1397950 1400625 ON 5 E15621 complement(1397950..1400625) some similarities with uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Regulator of Ty1 Transposition Establishes Silent Chromatin involved in silencing Klac_5.trna14A 1 1401022 1401094 ON 5 tA-AGC (1401022..1401094) tRNA Type: Ala (A) | Anti-Codon: AGC | Cove Score: 68.13 KLLA0E15665g 1 1401239 1401784 ON 5 E15665 (1401239..1401784) no similarity KLLA0E15687g 1 1402940 1406386 ON 5 E15687 (1402940..1406386) similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels required for derepression of PHO5 transcriptionally regulated by Pho4p and Pho2p KLLA0E15709g 0 1406502 1407194 ON 5 E15709 complement(1406502..1407194) similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Regulatory non-ATPase subunit of the 26S proteasome homolog of the human oncoprotein gankyrin which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 KLLA0E15731g 1 1407793 1408719 ON 5 E15731 (1407793..1408719) similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Possible role in aging mitochondrial protein prohibitin homolog homolog of mammalian BAP37 and S. cerevisiae Phb1p KLLA0E15753g 0 1409122 1409379 ON 5 E15753 complement(1409122..1409379) some similarities with uniprot|P50084 Saccharomyces cerevisiae YGR230W BNS1 Protein with some similarity to Spo12p KLLA0E15775g 1 1409984 1411591 ON 5 E15775 (1409984..1411591) similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in (1 3)-beta-glucan synthesis possibly through regulation of cell wall glucan and chitin synthesis chromatin binding protein 57 kDa nuclear protein KLLA0E15797g 0 1411759 1413360 ON 5 E15797 complement(1411759..1413360) similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent glucosyltransferase of the ER functions in the dolichol pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation has a role in regulation of ITR1 and INO1 KLLA0E15819g 1 1413530 1415068 ON 5 E15819 (1413530..1415068) weakly similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C hypothetical ORF KLLA0E15841g 0 1415149 1416792 ON 5 E15841 complement(1415149..1416792) similar to uniprot|Q75AQ6 Ashbya gossypii ADL136C ADL136Cp and weakly similar to YHR150W uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane protein involved in regulation of peroxisome size and number genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p Pex31p and Pex32p KLLA0E15863g 0 1417190 1418956 ON 5 E15863 complement(1417190..1418956) weakly similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Required for sporulation highly induced during sporulation activator of meiotic anaphase promoting complex Required for sporulation highly induced during sporulation KLLA0E15885g 1 1419922 1420941 ON 5 E15885 (1419922..1420941) weakly similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3 5- bisphosphate-binding protein predicted to fold as a seven- bladed beta-propeller displays punctate cytoplasmic localization KLLA0E15907g 0 1421034 1421798 ON 5 E15907 complement(1421034..1421798) weakly similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Protein required for splicing of the COX1 intron AI5 beta also specifically required together with Pet122p and Pet494p for translation of the COX3 mRNA located in the mitochondrial inner membrane KLLA0E15973g 1 1423143 1425209 ON 5 E15973 (1423143..1425209) some similarities with uniprot|P32900 Saccharomyces cerevisiae YHR149C SKG6 Protein of unknown function found in the bud tip and bud neck potential Cdc28p substrate KLLA0E15995g 0 1425473 1426024 ON 5 E15995 complement(1425473..1426024) highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome which is required for pre-18S rRNA processing essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA KLLA0E16017g 1 1426553 1427197 ON 5 E16017 (1426553..1427197) highly similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit KLLA0E16039g 1 1427540 1428361 ON 5 E16039 (1427540..1428361) similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit KLLA0E16061g 0 1428731 1431991 ON 5 E16061 complement(1428731..1431991) highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin involved in export of proteins RNAs and ribosomal subunits from the nucleus KLLA0E16083g 0 1432567 1438476 ON 5 E16083 complement(1432567..1438476) similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated calcium channel involved in calcium influx in response to mating pheromones KLLA0E16105g 1 1438802 1440682 ON 5 E16105 (1438802..1440682) similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol KLLA0E16127g 0 1440897 1441223 ON 5 E16127 complement(1440897..1441223) highly similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit KLLA0E16149g 1 1441386 1441550 ON 5 E16149 (1441386..1441550) no similarity KLLA0E16171g 0 1441784 1443244 ON 5 E16171 complement(1441784..1442458,1443155..1443244) highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W RPS0A protein component of the small (40S) ribosomal subunit KLLA0E16193g 1 1444770 1446443 ON 5 E16193 (1444770..1446443) similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C Hypothetical ORF KLLA0E16215g 0 1446699 1448177 ON 5 E16215 complement(1446699..1448177) highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p) KLLA0E16237g 1 1448683 1449912 ON 5 E16237 (1448683..1449912) highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Hypothetical ORF KLLA0E16259g 0 1450546 1452348 ON 5 E16259 complement(1450546..1452348) uniprot|Q70DJ7 Kluyveromyces lactis jen1 Lactate permease KLLA0E16281g 1 1455271 1457088 ON 5 E16281 (1455271..1457088) similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate also a transporter for Gln Asn Ser Ala and Gly KLLA0E16303g 0 1457903 1459594 ON 5 E16303 complement(1457903..1459594) highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde subject to glucose- ethanol- and autoregulation involved in amino acid catabolism KLLA0E16325g 0 1460849 1463347 ON 5 E16325 complement(1460849..1463347) weakly similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment interacts with spindle pole body component Spc72p KLLA0E16347g 1 1463917 1464231 ON 5 E16347 (1463917..1464231) highly similar to uniprot|P22217 Saccharomyces cerevisiae YLR043C TRX1 thioredoxin KLLA0E16369g 0 1464299 1465279 ON 5 E16369 complement(1464299..1465279) similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 phosphoserine phosphatase KLLA0E16391g 1 1465648 1466427 ON 5 E16391 (1465648..1466427) similar to uniprot|P42940 YGR207C Saccharomyces cerevisiae YGR2 Hypothetical ORF KLLA0E16413g 0 1466545 1466865 ON 5 E16413 complement(1466545..1466865) similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W KLLA0E16435g 1 1467102 1467719 ON 5 E16435 (1467102..1467719) similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C Hypothetical ORF KLLA0E16457g 0 1467758 1468048 ON 5 E16457 complement(1467758..1468048) similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Component of small nuclear ribonucleoprotein complexes involved in RNA processing and splicing Klac_YGOB_Anc_5.131 1 1468303 1469108 ON 5 Anc_5.131 (1468303..1468513,1468621..1469108) ANNOTATED BY YGOB - KLLA0E16501g 0 1469087 1469959 ON 5 E16501 complement(1469087..1469959) similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W Protein that binds ATP crystal structure resembles that of E.coli pantothenate kinase KLLA0E16523g 1 1470356 1471360 ON 5 E16523 (1470356..1471360) similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Thioesterase peroxisomal acyl-CoA thioesterase KLLA0E16545g 0 1471478 1474321 ON 5 E16545 complement(1471478..1474321) similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1- tetrahydrofolate synthase involved in single carbon metabolism and required for biosynthesis of purines thymidylate methionine and histidine KLLA0E16567g 1 1475343 1475831 ON 5 E16567 (1475343..1475831) similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline KLLA0E16589g 0 1475842 1476294 ON 5 E16589 complement(1475842..1476294) similar to uniprot|P42937 YGR203W Saccharomyces cerevisiae Probable protein tyrosine phosphatase of the CDC25-like phosphatase family KLLA0E16611g 0 1476592 1477821 ON 5 E16611 complement(1476592..1477821) similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase KLLA0E16633g 0 1478514 1479083 ON 5 E16633 complement(1478514..1479083) similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C Hypothetical ORF KLLA0E16655g 1 1479322 1481292 ON 5 E16655 (1479322..1481292) similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Hypothetical ORF KLLA0E16677g 0 1481372 1482289 ON 5 E16677 complement(1481372..1482289) similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import interacts with Pex12p links ubiquitin-conjugating Pex4p to protein import machinery mutations in human homolog cause a variety of peroxisomal disorders KLLA0E16699g 1 1482505 1484490 ON 5 E16699 (1482505..1484490) similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain binds to myosin motor domains to regulate myosin function involved in endocytosis polarization of the actin cytoskeleton and asymmetric mRNA localization KLLA0E16721g 1 1484752 1487010 ON 5 E16721 (1484752..1487010) similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C AKR1 Palmitoyl transferase involved in protein palmitoylation KLLA0E16743g 1 1487301 1489316 ON 5 E16743 (1487301..1489316) some similarities with uniprot|P39875 Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap- endonuclease involved in recombination double-strand break repair and DNA mismatch repair member of the Rad2p nuclease family with conserved N and I nuclease domains KLLA0E16765g 1 1489864 1492689 ON 5 E16765 (1489864..1492689) some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 C2H2 zinc-finger protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant KLLA0E16787g 0 1493491 1494291 ON 5 E16787 complement(1493491..1494291) similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Hypothetical ORF Klac_5.trna15G 0 1494575 1494645 ON 5 tG-GCC complement(1494575..1494645) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0E16831g 0 1494849 1496297 ON 5 E16831 complement(1494849..1496297) some similarities with uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein involved in invasive growth upon nitrogen starvation KLLA0E16853g 1 1496719 1497051 ON 5 E16853 (1496719..1497051) conserved hypothetical protein KLLA0E16875g 1 1498623 1500149 ON 5 E16875 (1498623..1500149) some similarities with uniprot|P40917 Saccharomyces cerevisiae YOR028C CIN5 Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus KLLA0E16897g 1 1500700 1503177 ON 5 E16897 (1500700..1503177) highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock prevents the aggregation of misfolded matrix proteins component of the mitochondrial proteolysis system KLLA0E16919g 0 1503510 1507520 ON 5 E16919 complement(1503510..1507520) weakly similar to uniprot|Q06681 Saccharomyces cerevisiae YDR326C Hypothetical ORF KLLA0E16941g 0 1507885 1508433 ON 5 E16941 complement(1507885..1508433) similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 evolutionarily conserved kinetochore protein that is part of multiple protein complexes KLLA0E16963g 0 1508739 1510190 ON 5 E16963 complement(1508739..1510190) similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 peroxisomal membrane protein KLLA0E16985g 0 1510635 1511153 ON 5 E16985 complement(1510635..1511153) conserved hypothetical protein KLLA0E17007g 1 1511603 1512136 ON 5 E17007 (1511603..1512136) similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs homolog of mammalian nuclear matrix protein C1D which is involved in regulation of DNA repair and recombination KLLA0E17029g 1 1512395 1513939 ON 5 E17029 (1512395..1513939) similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p KLLA0E17051g 1 1514295 1515521 ON 5 E17051 (1514295..1515521) similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins KLLA0E17073g 0 1515721 1518279 ON 5 E17073 complement(1515721..1518279) similar to uniprot|Q759H7 Ashbya gossypii ADR300C ADR300Cp and weakly similar to YHR082C uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Nonessential putative serine/threonine protein kinase of unknown cellular role overproduction causes allele-specific suppression of the prp20-10 mutation KLLA0E17095g 1 1519323 1521395 ON 5 E17095 (1519323..1521395) similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W Hypothetical ORF KLLA0E17117g 1 1521682 1522686 ON 5 E17117 (1521682..1522686) weakly similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex aka TOB complex) of the mitochondrial outer membrane which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane KLLA0E17139g 1 1523750 1525750 ON 5 E17139 (1523750..1525750) uniprot|Q08400 Kluyveromyces lactis STE12 Protein STE12 KLLA0E17161g 1 1526177 1527430 ON 5 E17161 (1526177..1527430) similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis the authentic non-tagged protein was localized to mitochondria KLLA0E17183g 0 1527770 1529203 ON 5 E17183 complement(1527770..1529203) highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis KLLA0E17205g 1 1530035 1530862 ON 5 E17205 (1530035..1530862) similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis participates in endoplasmic reticulum (ER) protein sorting KLLA0E17227g 0 1531243 1531854 ON 5 E17227 complement(1531243..1531854) similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Yeast Ran Binder #1 suppressor of FUS1 homolog of mouse HTF9a and human RanBP1 nuclear GTPase- activating protein for Ran KLLA0E17249g 1 1532193 1532567 ON 5 E17249 (1532193..1532567) no similarity KLLA0E17271g 1 1533054 1535318 ON 5 E17271 (1533054..1535318) highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C NTH1 Neutral trehalase degrades trehalose required for thermotolerance and may mediate resistance to other cellular stresses may be phosphorylated by Cdc28p KLLA0E17293g 1 1535737 1536822 ON 5 E17293 (1535737..1536822) no similarity KLLA0E17315g 1 1537446 1537886 ON 5 E17315 (1537446..1537487,1537614..1537886) highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function KLLA0E17337g 0 1538169 1538567 ON 5 E17337 complement(1538169..1538567) similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation KLLA0E17359g 1 1539714 1540106 ON 5 E17359 (1539714..1540106) similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p KLLA0E17381g 0 1540387 1541721 ON 5 E17381 complement(1540387..1541721) similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation KLLA0E17403g 1 1542238 1542975 ON 5 E17403 (1542238..1542975) similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins likely component of the INO80 complex which is an ATP-dependent chromatin-remodeling complex KLLA0E17425g 0 1543158 1550639 ON 5 E17425 complement(1543158..1550639) similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Possible snoRNA-binding protein based on computational analysis of large-scale protein-protein interaction data KLLA0E17447g 1 1551621 1552259 ON 5 E17447 (1551621..1552259) weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W KLLA0E17469g 1 1552950 1553492 ON 5 E17469 (1552950..1553492) some similarities with uniprot|Q03446 Saccharomyces cerevisiae YDR003W KLLA0E17491g 1 1553982 1555475 ON 5 E17491 (1553982..1555475) highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma- aminobutyrate (GABA) as a nitrogen source part of the 4- aminobutyrate and glutamate degradation pathways localized to the cytoplasm KLLA0E17513g 1 1555877 1557319 ON 5 E17513 (1555877..1557319) similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis forms heterodimer with Rad55p KLLA0E17535g 0 1557680 1558669 ON 5 E17535 complement(1557680..1558669) similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment targets the initiation factor TFIIIB KLLA0E17557g 0 1559577 1561637 ON 5 E17557 complement(1559577..1561637) weakly similar to YBR007C, uniprot|P38213 Saccharomyces cerevisiae YBR007C (DSF2) KLLA0E17579g 0 1562195 1565467 ON 5 E17579 complement(1562195..1565467) similar to uniprot|P40317 Saccharomyces cerevisiae YDR006C (SOK1), KLLA0E17601g 0 1566673 1566984 ON 5 E17601 complement(1566673..1566984) highly similar to uniprot|P02309 Saccharomyces cerevisiae YBR009C HHF1 and highly similar to uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2, two identical histone H4 proteins; core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity KLLA0E17623g 1 1567814 1568224 ON 5 E17623 (1567814..1568224) highly similar to uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 and highly similar to uniprot|P02303 Saccharomyces cerevisiae YBR010W HHT1 histone H3 proteins KLLA0E17645g 1 1568538 1569170 ON 5 E17645 (1568538..1569170) similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis in 2004 the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) KLLA0E17667g 0 1569250 1570233 ON 5 E17667 complement(1569250..1570233) highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase) catalyzes the rapid exchange of oxygens from Pi with water highly expressed and essential for viability active-site residues show identity to those from E. coli PPase Klac_5.trna16T 1 1570786 1570858 ON 5 tT-AGU (1570786..1570858) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 KLLA0E17711g 0 1571018 1571506 ON 5 E17711 complement(1571018..1571506) similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase- Promoting Complex/Cyclosome (APC/C) which is a ubiquitin- protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition KLLA0E17733g 0 1571724 1572359 ON 5 E17733 complement(1571724..1572359) similar to Saccharomyces cerevisiae YDL010W Hypothetical ORF or YBR014C uniprot|P38068 Saccharomyces cerevisiae YBR014C Hypothetical ORF KLLA0E17755g 0 1572985 1574901 ON 5 E17755 complement(1572985..1574901) similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment KLLA0E17777g 0 1575809 1578121 ON 5 E17777 complement(1575809..1578121) similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Subunit of the NatB N-terminal acetyltransferase which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met involved in mitochondrial inheritance and actin assembly KLLA0E17799g 1 1578734 1579630 ON 5 E17799 (1578734..1579630) highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein involved in the biogenesis of large ribosomal subunits depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits possesses a sigma(70)-like RNA- binding motif Klac_YGOB_Anc_3.128 0 1580136 1580345 ON 5 Anc_3.128 complement(1580136..1580345) ANNOTATED BY YGOB - KLLA0E17821g 1 1581075 1582550 ON 5 E17821 (1581075..1582550) similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Hypothetical ORF KLLA0E17843g 0 1582644 1585943 ON 5 E17843 complement(1582644..1585943) weakly similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins which may have a role in regulation of cell growth KLLA0E17865g 1 1586485 1587369 ON 5 E17865 (1586485..1587369) similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly KLLA0E17887g 0 1587614 1596283 ON 5 E17887 complement(1587614..1596283) similar to uniprot|P18963 Saccharomyces cerevisiae YBR140c IRA1 or uniprot|P19158 Saccharomyces cerevisiae YOL081w IRA2 KLLA0E17909g 0 1596954 1597970 ON 5 E17909 complement(1596954..1597970) some similarities with uniprot|P53938 Saccharomyces cerevisiae YNL080C KLLA0E17931g 0 1598775 1599499 ON 5 E17931 complement(1598775..1599242,1599482..1599499) similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C TPM2 Tropomyosin isoform 2 actin-binding protein that stabilizes actin filaments required with Tpm1 the main tropomyosin for the formation and stability of actin cables in vivo which direct polarized cell growth and the distribution of several organelles KLLA0E17953g 0 1600015 1603470 ON 5 E17953 complement(1600015..1603470) similar to uniprot|P40578 MGA2 and to YKL020C uniprot|P35210 SPT23, Saccharomyces cerevisiae ER membrane proteins involved in regulation of OLE1 transcription KLLA0E17975g 1 1604192 1605133 ON 5 E17975 (1604192..1605133) similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 CAAX farnesyltransferase alpha subunit KLLA0E17997g 1 1605435 1606502 ON 5 E17997 (1605435..1606502) similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 nitrogen starvation-induced protein phosphatase KLLA0E18019g 0 1606595 1607410 ON 5 E18019 complement(1606595..1607410) weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC) needed for meiotic nuclear division KLLA0E18041g 0 1607729 1608102 ON 5 E18041 complement(1607729..1607980,1608097..1608102) weakly similar to YKL018c-a, Hypothetical ORF KLLA0E18063g 1 1608371 1609351 ON 5 E18063 (1608371..1609351) highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres KLLA0E18085g 0 1609333 1611378 ON 5 E18085 complement(1609333..1611378) similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis contains single-stranded DNA stimulated ATPase and dATPase activities replication protein A stimulates helicase and ATPase activities KLLA0E18107g 0 1611632 1612156 ON 5 E18107 complement(1611632..1612156) highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase which is a large evolutionarily conserved enzyme complex required for ATP synthesis KLLA0E18129g 1 1613115 1615712 ON 5 E18129 (1613115..1615712) similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Positive regulator of PUT (proline utilization) genes zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type KLLA0E18151g 0 1615820 1620910 ON 5 E18151 complement(1615820..1620910) similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit KLLA0E18173g 1 1621494 1622186 ON 5 E18173 (1621494..1622186) similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C (putative) involved in cell cycle control KLLA0E18195g 0 1622300 1625701 ON 5 E18195 complement(1622300..1625701) similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism KLLA0E18217g 0 1626079 1626594 ON 5 E18217 complement(1626079..1626594) highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches KLLA0E18239g 1 1627093 1628808 ON 5 E18239 (1627093..1628808) similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing interacts with the branchpoint-binding protein during the formation of the second commitment complex KLLA0E18261g 0 1628878 1629387 ON 5 E18261 complement(1628878..1629387) highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC Spc1p Spc2p Spc3p and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum KLLA0E18283g 1 1629714 1630394 ON 5 E18283 (1629714..1630394) similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Hypothetical ORF KLLA0E18305g 0 1630521 1631597 ON 5 E18305 complement(1630521..1631597) weakly similar to uniprot|Q03702 Saccharomyces cerevisiae YKL011C CCE1 cruciform cutting endonuclease KLLA0E18327g 1 1631929 1632564 ON 5 E18327 (1631929..1632564) no similarity KLLA0E18349g 1 1632967 1634598 ON 5 E18349 (1632967..1634598) some similarities with uniprot|P36076 Saccharomyces cerevisiae YKL088W Protein required for cell viability KLLA0E18371g 1 1635391 1637427 ON 5 E18371 (1635391..1637427) conserved hypothetical protein KLLA0E18393g 0 1638238 1638966 ON 5 E18393 complement(1638238..1638966) conserved hypothetical protein KLLA0E18415g 0 1639415 1640116 ON 5 E18415 complement(1639415..1640116) conserved hypothetical protein KLLA0E18459g 1 1641507 1641953 ON 5 E18459 (1641507..1641953) similar to uniprot|Q59TA9 Candida albicans CaO19 Potential heme/steroid binding protein and some similarites with YMR073C uniprot|Q04772 Saccharomyces cerevisiae YMR073C Hypothetical ORF KLLA0E18481g 0 1642554 1643948 ON 5 E18481 complement(1642554..1643948) some similarities with uniprot|P33417 Saccharomyces cerevisiae YKL032C IXR1 Protein that binds DNA containing intrastrand cross-links formed by cisplatin contains two HMG (high mobility group box) domains which confer the ability to bend cisplatin-modified DNA mediates aerobic transcriptional repression of COX5b KLLA0E18503g 0 1645113 1647065 ON 5 E18503 complement(1645113..1647065) conserved hypothetical protein KLLA0E18525g 1 1647606 1648121 ON 5 E18525 (1647606..1648121) similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Tlg2-Vesicle Protein of 18 kDa Integral membrane vesicle protein KLLA0E18547g 0 1648263 1649558 ON 5 E18547 complement(1648263..1649558) some similarities with uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers involved in repression of a subset of hypoxic genes by Rox1p repression of several DAN/TIR genes during aerobic growth and repression of ergosterol biosynthetic genes KLLA0E18569g 0 1651949 1652596 ON 5 E18569 complement(1651949..1652596) no similarity KLLA0E18613g 1 1652892 1654016 ON 5 E18613 (1652892..1654016) similar to uniprot|Q750M6 Ashbya gossypii AGL070W AGL070Wp and weakly similar to YHR004C uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Protein of the nuclear envelope required for the spherical shape of the nucleus required for normal sporulation KLLA0E18635g 1 1654950 1656872 ON 5 E18635 (1654950..1656872) highly similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids KLLA0E18657g 1 1657394 1658986 ON 5 E18657 (1657394..1658986) similar to uniprot|Q750M4 Ashbya gossypii AGL067W AGL067Wp and some similarites with YKL028W uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit involved in recruitment of RNA polymerase II to the promoter activation of TFIIH and promoter opening KLLA0E18679g 1 1659258 1660598 ON 5 E18679 (1659258..1660598) similar to uniprot|P36101 Saccharomyces cerevisiae YKL027W Hypothetical ORF KLLA0E18701g 0 1661093 1662238 ON 5 E18701 complement(1661093..1662238) similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix homolog of human Graves disease protein does not encode an isozyme of Leu4p as first hypothesized KLLA0E18723g 1 1663220 1664353 ON 5 E18723 (1663220..1664353) highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter member of the mitochondrial carrier family KLLA0E18745g 0 1664971 1665921 ON 5 E18745 complement(1664971..1665921) similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded controls metal ion transport prevents metal hyperaccumulation functions in copper detoxification KLLA0E18767g 0 1666322 1668724 ON 5 E18767 complement(1666322..1668724) some similarities with uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Involved in global regulation of transcription subunit of the chromatin remodeling Snf/Swi complex KLLA0E18789g 1 1669103 1670596 ON 5 E18789 (1669103..1670596) similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway clathrin associated protein medium chain KLLA0E18811g 1 1670923 1672263 ON 5 E18811 (1670923..1672263) similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter contains a PHD finger domain KLLA0E18833g 0 1672341 1674074 ON 5 E18833 complement(1672341..1674074) similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p family essential for vacuolar protein sorting required for the function of both Pep12p and the early endosome/late Golgi SNARE Tlg2p KLLA0E18855g 1 1674432 1676600 ON 5 E18855 (1674432..1676600) weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Tor Complex One KLLA0E18877g 0 1676876 1680310 ON 5 E18877 complement(1676876..1680310) similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)- ribonuclease complex which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes KLLA0E18899g 1 1680775 1683747 ON 5 E18899 (1680775..1683747) similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C Hypothetical ORF KLLA0E18921g 0 1683925 1684167 ON 5 E18921 complement(1683925..1684167) similar to uniprot|O14464 Saccharomyces cerevisiae YPL183W-A, ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome KLLA0E18943g 1 1684751 1687216 ON 5 E18943 (1684751..1687216) weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Protein required for accurate chromosome segregation KLLA0E18965g 1 1687547 1691506 ON 5 E18965 (1687547..1691506) weakly similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex KLLA0E18987g 0 1691643 1692623 ON 5 E18987 complement(1691643..1692623) highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential nuclear protein evolutionarily conserved putative ATPase exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta KLLA0E19009g 1 1692900 1693718 ON 5 E19009 (1692900..1693718) conserved hypothetical protein KLLA0E19031g 1 1694566 1696524 ON 5 E19031 (1694566..1696524) similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C Hypothetical ORF KLLA0E19053g 1 1697655 1698314 ON 5 E19053 (1697655..1698314) some similarities with uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein of unknown function KLLA0E19075g 0 1698739 1699302 ON 5 E19075 complement(1698739..1699302) similar to uniprot|P01149 Saccharomyces cerevisiae YPL187W MF(ALPHA)1 Mating pheromone alpha-factor made by alpha cells interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating also encoded by MF(ALPHA)2 although MF(ALPHA)1 produces most alpha-factor KLLA0E19097g 0 1700712 1701974 ON 5 E19097 complement(1700712..1701974) highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase phosphorylates NADH also phosphorylates NAD( ) with lower specificity required for the response to oxidative stress KLLA0E19119g 0 1702717 1703236 ON 5 E19119 complement(1702717..1703125,1703226..1703236) highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Protein involved in error-free postreplication DNA repair forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity cooperates with chromatin-associated RING finger proteins Rad18p and Rad5p KLLA0E19141g 1 1703466 1705412 ON 5 E19141 (1703466..1705412) similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle- assembly checkpoint phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex forms a complex with Mad2p KLLA0E19163g 1 1705629 1706441 ON 5 E19163 (1705629..1706441) similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W Hypothetical ORF KLLA0E19185g 0 1706645 1708408 ON 5 E19185 complement(1706645..1708408) similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C GUP1 Multimembrane-spanning protein or to uniprot|Q08929 Saccharomyces cerevisiae YPL189w active glycerol transporter (putative) KLLA0E19207g 1 1709335 1711638 ON 5 E19207 (1709335..1711638) similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Suppressor of GTPase mutant Klac_YGOB_Anc_6.192 1 1712020 1712220 ON 5 Anc_6.192 (1712020..1712220) ANNOTATED BY YGOB - KLLA0E19229g 1 1713099 1715318 ON 5 E19229 (1713099..1715318) similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded DNA binding protein acidic ribonucleoprotein required for termination of non-poly(A) transcripts and efficient splicing interacts with Nrd1p KLLA0E19251g 1 1715991 1717967 ON 5 E19251 (1715991..1717967) similar to uniprot|Q08989 Saccharomyces cerevisiae YPL277C Hypothetical ORFs KLLA0E19273g 1 1718449 1719495 ON 5 E19273 (1718449..1719495) similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W and similar to uniprot|Q08930 Saccharomyces cerevisiae YPL191C Hypothetical ORFs KLLA0E19295g 1 1720040 1721050 ON 5 E19295 (1720040..1721050) some similarities with YGL081w KLLA0E19317g 1 1721330 1721728 ON 5 E19317 (1721330..1721728) no similarity KLLA0E19339g 0 1721747 1722775 ON 5 E19339 complement(1721747..1722775) similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 RiboSome Assembly KLLA0E19361g 1 1723526 1723900 ON 5 E19361 (1723526..1723900) similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37 KLLA0E19383g 0 1724099 1725760 ON 5 E19383 complement(1724099..1725760) similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein part of a PCNA- like complex required for DNA damage response required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates potential Cdc28p substrate KLLA0E19405g 0 1725950 1728676 ON 5 E19405 complement(1725950..1728676) similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway suppressor of loss of casein kinase 1 function delta-like subunit of the yeast AP-3 adaptin component of the membrane-associated clathrin assembly complex KLLA0E19427g 1 1728952 1729488 ON 5 E19427 (1728952..1729488) similar to uniprot|Q755A2 Ashbya gossypii AFL077C AFL077Cp and weakly similar to YGL079W uniprot|P53158 Saccharomyces cerevisiae YGL079W Hypothetical ORF KLLA0E19449g 0 1729566 1730318 ON 5 E19449 complement(1729566..1730318) similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage null mutants are sensitive to hydrogen peroxide KLLA0E19471g 0 1730651 1732372 ON 5 E19471 complement(1730651..1732372) conserved hypothetical protein KLLA0E19493g 1 1732921 1733478 ON 5 E19493 (1732921..1733478) weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C Protein of unknown function, transcript accumulates in response to any combination of stress conditions KLLA0E19515g 0 1733708 1735426 ON 5 E19515 complement(1733708..1735426) similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1 KLLA0E19537g 1 1736016 1737359 ON 5 E19537 (1736016..1737359) similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase catalyzes the cotranslational covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction KLLA0E19559g 1 1737862 1738464 ON 5 E19559 (1737862..1738464) some similarities with uniprot|Q05777 Saccharomyces cerevisiae YLR194C Hypothetical ORF KLLA0E19581g 1 1738957 1739481 ON 5 E19581 (1738957..1739481) similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C Hypothetical ORF KLLA0E19603g 0 1739869 1741914 ON 5 E19603 complement(1739869..1741914) weakly similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W KLLA0E19625g 1 1743508 1749933 ON 5 E19625 (1743508..1749933) highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD( )-dependent glutamate synthase (GOGAT) synthesizes glutamate from glutamine and alpha-ketoglutarate with Gln1p forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source KLLA0E19647g 0 1750310 1750777 ON 5 E19647 complement(1750310..1750777) weakly similar to uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W Hypothetical ORF KLLA0E19669g 1 1751471 1752304 ON 5 E19669 (1751471..1752304) similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA KLLA0E19691g 1 1752867 1754597 ON 5 E19691 (1752867..1754597) uniprot|Q12627 Kluyveromyces lactis DLD1 D-lactate dehydrogenase mitochondrial precursor KLLA0E19713g 1 1755931 1756362 ON 5 E19713 (1755931..1756362) conserved hypothetical protein KLLA0E19735g 0 1756682 1757908 ON 5 E19735 complement(1756682..1757908) similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane receptor KLLA0E19757g 0 1758427 1759794 ON 5 E19757 complement(1758427..1759794) weakly similar to uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p KLLA0E19779g 0 1760800 1762503 ON 5 E19779 complement(1760800..1762503) highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase catalyzes the first step in isoleucine biosynthesis expression is under general amino acid control ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation KLLA0E19801g 1 1763061 1764710 ON 5 E19801 (1763061..1764710) similar to uniprot|P39965 Saccharomyces cerevisiae YER087W Hypothetical ORF KLLA0E19823g 0 1765241 1765507 ON 5 E19823 complement(1765241..1765507) similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A SBH2 Ssh1p-Sss1p-Sbh2p complex component involved in protein translocation into the endoplasmic reticulum homologous to Sbh1p KLLA0E19845g 1 1766853 1768631 ON 5 E19845 (1766853..1768631) similar to uniprot|Q75BN6 Ashbya gossypii ACR235W ACR235Wp and weakly similar to YBL051C uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage interacts with Rad53p contains an RNA recognition motif a nuclear localization signal and several SQ/TQ cluster domains hyperphosphorylated in response to DNA damage KLLA0E19867g 1 1769223 1769594 ON 5 E19867 (1769223..1769594) no similarity KLLA0E19889g 1 1770061 1771161 ON 5 E19889 (1770061..1771161) similar to uniprot|Q04894 Saccharomyces cerevisiae YMR318C ADH6 NADPH-dependent cinnamyl alcohol dehydrogenase family member with broad substrate specificity may be involved in fusel alcohol synthesis or in aldehyde tolerance KLLA0E19911g 1 1771778 1773976 ON 5 E19911 (1771778..1773976) similar to uniprot|Q75BN5 Ashbya gossypii ACR236W ACR236Wp and weakly similar to YBL052C uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3 involved in transcriptional silencing homolog of the mammalian MOZ proto-oncogene sas3 gcn5 double mutation confers lethality KLLA0E19933g 0 1774534 1776285 ON 5 E19933 complement(1774534..1776285) some similarities with uniprot|P40059 Saccharomyces cerevisiae YER088C DOT6 Protein of unknown function involved in telomeric gene silencing and filamentation KLLA0E19955g 1 1777217 1778563 ON 5 E19955 (1777217..1778563) similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C Hypothetical ORF KLLA0E19977g 0 1779199 1780515 ON 5 E19977 complement(1779199..1780515) similar to uniprot|P34221 Saccharomyces cerevisiae YBL056W PTC3 Type 2C protein phosphatase dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p) role in DNA checkpoint inactivation KLLA0E19999g 1 1781349 1782875 ON 5 E19999 (1781349..1782875) similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 anthranilate synthase Component I KLLA0E20021g 1 1783264 1783908 ON 5 E20021 (1783264..1783908) similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 mitochondrially-localized peptidyl-tRNA hydrolase KLLA0E20043g 0 1784051 1785253 ON 5 E20043 complement(1784051..1785253) similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain- containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate KLLA0E20065g 0 1786006 1788312 ON 5 E20065 complement(1786006..1788312) highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase involved in amino acid biosynthesis also called N5-methyltetrahydrofolate homocysteine methyltransferase or 5-methyltetrahydropteroyltriglutamate homocysteine methyltransferase KLLA0E20087g 0 1788696 1789070 ON 5 E20087 complement(1788696..1789070) no similarity KLLA0E20109g 1 1789335 1789688 ON 5 E20109 (1789335..1789688) similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions KLLA0E20131g 0 1789708 1793664 ON 5 E20131 complement(1789708..1793664) similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Binding Protein of TOR Protein required for cell viability KLLA0E20153g 0 1793963 1794492 ON 5 E20153 complement(1793963..1794258,1794336..1794492) similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A Hypothetical ORF KLLA0E20175g 1 1794752 1795165 ON 5 E20175 (1794752..1794785,1794879..1795165) highly similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059ca KLLA0E20197g 0 1795485 1796102 ON 5 E20197 complement(1795485..1796102) highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism human homolog is subunit C10 KLLA0E20219g 0 1796579 1798423 ON 5 E20219 complement(1796579..1798423) weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W Hypothetical ORF KLLA0E20241g 1 1799331 1800440 ON 5 E20241 (1799331..1800440) uniprot|Q6XCZ0 Kluyveromyces lactis RAD51 Rad51p KLLA0E20263g 1 1801106 1803187 ON 5 E20263 (1801106..1803187) similar to uniprot|P34226 Saccharomyces cerevisiae YBL061C SKT5 Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation KLLA0E20285g 1 1803791 1804540 ON 5 E20285 (1803791..1804540) similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity has a role in reduction of hydroperoxides induced during respiratory growth and under conditions of oxidative stress KLLA0E20307g 1 1806005 1809364 ON 5 E20307 (1806005..1809364) uniprot|P87164 Kluyveromyces lactis SEF1 Suppressor protein SEF1 Klac_5.trna17H 1 1809819 1809890 ON 5 tH-GUG (1809819..1809890) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 68.23 KLLA0E20351g 1 1810593 1812686 ON 5 E20351 (1810593..1812686) similar to uniprot|P39967 Saccharomyces cerevisiae YER098W UBP9 Ubiquitin-specific protease that cleaves ubiquitin-protein fusions KLLA0E20373g 0 1812974 1813948 ON 5 E20373 complement(1812974..1813948) highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C PRS2 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes KLLA0E20395g 1 1814618 1815373 ON 5 E20395 (1814618..1815373) similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER- associated protein degradation located at the cytosolic side of the ER membrane tail region contains a transmembrane segment at the C-terminus substrate of the ubiquitin-proteasome pathway KLLA0E20417g 0 1815696 1816982 ON 5 E20417 complement(1815696..1816982) weakly similar to uniprot|P35183 Saccharomyces cerevisiae YBL069W AST1 peripheral membrane protein KLLA0E20439g 0 1817441 1817689 ON 5 E20439 complement(1817441..1817689) highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Protein required along with Dph1p Dph2p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Dph2p KLLA0E20461g 1 1818978 1819583 ON 5 E20461 (1818978..1819583) similar to uniprot|P05754 Saccharomyces cerevisiae YER102W RPS8B protein component of the small (40S) ribosomal subunit KLLA0E20505g 1 1820449 1821522 ON 5 E20505 (1820449..1821522) similar to uniprot|Q74Z30 Ashbya gossypii AGR376W AGR376Wp and weakly similar to YBL074C uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP required for splicing of U3 precursors originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron KLLA0E20527g 1 1822412 1824364 ON 5 E20527 (1822412..1824364) highly similar to uniprot|P09435 Saccharomyces cerevisiae YBL075C SSA3 heat-inducible cytosolic member of the 70 kDa heat shock protein family KLLA0E20549g 1 1825036 1828257 ON 5 E20549 (1825036..1828257) highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase target of the G1-specific inhibitor reveromycin A KLLA0E20571g 1 1828627 1829190 ON 5 E20571 (1828627..1829190) some similarities with uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 same phenotype as RTT101, 102, 103, 104; Regulator of Ty1 Transposition KLLA0E20593g 1 1829697 1830071 ON 5 E20593 (1829697..1830071) highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Protein required for autophagy KLLA0E20615g 0 1830746 1835104 ON 5 E20615 complement(1830746..1835104) similar to uniprot|P38181 Saccharomyces cerevisiae YBL079W NUP170 Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation KLLA0E20637g 1 1835743 1836678 ON 5 E20637 (1835743..1836678) weakly similar to uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle KLLA0E20659g 1 1837058 1838677 ON 5 E20659 (1837058..1838677) similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Protein required for mitochondrial translation KLLA0E20681g 0 1839142 1840266 ON 5 E20681 complement(1839142..1840266) weakly similar to uniprot|P38180 Saccharomyces cerevisiae YBL081W Hypothetical ORF KLLA0E20703g 0 1841092 1842207 ON 5 E20703 complement(1841092..1842207) similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import homologous to S. pombe Rae1p KLLA0E20725g 0 1842953 1845673 ON 5 E20725 complement(1842953..1845673) some similarities with uniprot|P40068 Saccharomyces cerevisiae YER109c PHD5 required for diploid filamentous growth singleton KLLA0E20747g 0 1846948 1848336 ON 5 E20747 complement(1846948..1848336) similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C RHK1 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase involved in the synthesis of dolichol- linked oligosaccharide donor for N-linked glycosylation of proteins KLLA0E20769g 0 1848703 1852044 ON 5 E20769 complement(1848703..1852044) highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4 localizes to the nuclear pore nucleus and cytoplasm exhibits genetic interactions with RAI1 KLLA0E20791g 0 1852522 1855323 ON 5 E20791 complement(1852522..1855323) some similarities with uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 Involved in cell cycle dependent gene expression transcription factor KLLA0E20813g 1 1856387 1856938 ON 5 E20813 (1856387..1856938) uniprot|Q96UG3 Kluyveromyces lactis KLLA0E20889g putative hypothetical protein putative LSM4 KLLA0E20835g 0 1857426 1859456 ON 5 E20835 complement(1857426..1859456) similar to uniprot|P40071 Saccharomyces cerevisiae YER113C Hypothetical ORF KLLA0E20857g 1 1860517 1862649 ON 5 E20857 (1860517..1862649) similar to uniprot|Q751K0 Ashbya gossypii AGL294W AGL294Wp and some similarites with YBL084C uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors including mitotic cyclins during the metaphase/anaphase transition KLLA0E20879g 0 1862894 1865941 ON 5 E20879 complement(1862894..1865941) similar to uniprot|P39969 Saccharomyces cerevisiae YER114C BOI2 Protein implicated in polar growth functionally redundant with Boi1p interacts with bud- emergence protein Bem1p contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain KLLA0E20901g 0 1866407 1867567 ON 5 E20901 complement(1866407..1867567) conserved hypothetical protein KLLA0E20923g 1 1868214 1869524 ON 5 E20923 (1868214..1869524) similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery KLLA0E20945g 1 1870154 1871740 ON 5 E20945 (1870154..1871740) weakly similar to uniprot|P42833 Saccharomyces cerevisiae YNL318C, HXT14 protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studie KLLA0E20967g 1 1872227 1876192 ON 5 E20967 (1872227..1876192) similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C Hypothetical ORF KLLA0E20989g 0 1876222 1877082 ON 5 E20989 complement(1876222..1877082) similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Hypothetical ORF KLLA0E21011g 1 1877678 1878310 ON 5 E21011 (1877678..1878310) similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein the eIF4E-cap complex is responsible for mediating cap- dependent mRNA translation via interactions with the translation initiation factor eIF4G (Tif4631p or Tif4632p) KLLA0E21033g 0 1878737 1881682 ON 5 E21033 complement(1878737..1881682) similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W Protein of unknown function potential Cdc28p substrate KLLA0E21055g 1 1882430 1883215 ON 5 E21055 (1882430..1883215) weakly similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor KLLA0E21077g 0 1883452 1884723 ON 5 E21077 complement(1883452..1884723) highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine KLLA0E21099g 0 1885338 1886127 ON 5 E21099 complement(1885338..1885976,1886092..1886127) similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0E21121g 1 1886452 1888032 ON 5 E21121 (1886452..1888032) similar to uniprot|Q12196 YOR119C Saccharomyces cerevisiae RIO1 Essential protein that plays a role in cell cycle progression KLLA0E21143g 0 1888085 1889803 ON 5 E21143 complement(1888085..1889803) similar to uniprot|Q12108 YOR118W Saccharomyces cerevisiae Hypothetical ORF KLLA0E21165g 1 1890314 1892197 ON 5 E21165 (1890314..1892197) similar to uniprot|Q06344 YDR365C Saccharomyces cerevisiae ESF1 Nucleolar protein involved in pre-rRNA processing KLLA0E21187g 1 1892524 1893813 ON 5 E21187 (1892524..1893813) similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression required for DNA synthesis during mitosis and meiosis has WD repeats KLLA0E21209g 0 1893904 1895202 ON 5 E21209 complement(1893904..1895202) highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates recruited to the GAL1-10 promoter region upon induction of transcription KLLA0E21231g 0 1895618 1895812 ON 5 E21231 complement(1895618..1895812) similar to uniprot|O94742 Saccharomyces cerevisiae YDR363W-A Component of the lid subcomplex of the regulatory subunit of the 26S proteasome KLLA0E21253g 1 1896457 1900830 ON 5 E21253 (1896457..1900830) highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C KLLA0E21275g 0 1900927 1902105 ON 5 E21275 complement(1900927..1902105) some similarities with uniprot|Q06340 YDR363W Saccharomyces cerevisiae ESC2 Protein involved in mating- type locus silencing interacts with Sir2p KLLA0E21297g 0 1902420 1903919 ON 5 E21297 complement(1902420..1903919) similar to uniprot|P38821 YHR113W Saccharomyces cerevisiae Hypothetical ORF KLLA0E21319g 1 1904841 1905983 ON 5 E21319 (1904841..1905983) highly similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Hypothetical ORF KLLA0E21341g 1 1906322 1908136 ON 5 E21341 (1906322..1908136) weakly similar to uniprot|Q06339 YDR362C Saccharomyces cerevisiae TFC6 one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) KLLA0E21363g 0 1908181 1909515 ON 5 E21363 complement(1908181..1909515) similar to uniprot|P38820 YHR111W Saccharomyces cerevisiae UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation) KLLA0E21385g 0 1909837 1910478 ON 5 E21385 complement(1909837..1910478) similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W KLLA0E21407g 0 1910837 1912348 ON 5 E21407 complement(1910837..1912348) weakly similar to uniprot|P38818 YHR109W Saccharomyces cerevisiae CTM1 Cytochrome c lysine methyltransferase KLLA0E21429g 1 1912931 1913749 ON 5 E21429 (1912931..1913749) similar to uniprot|Q06338 YDR361C Saccharomyces cerevisiae BCP1 Essential protein involved in nuclear export of Mss4p KLLA0E21451g 1 1914249 1917266 ON 5 E21451 (1914249..1917266) similar to uniprot|Q06337 YDR359C Saccharomyces cerevisiae VID21 Component of the NuA4 histone acetyltransferase complex KLLA0E21473g 0 1917382 1919127 ON 5 E21473 complement(1917382..1919127) some similarities with uniprot|P38817 YHR108W Saccharomyces cerevisiae GGA2 Golgi-localized protein with homology to gamma-adaptin KLLA0E21495g 1 1919564 1919938 ON 5 E21495 (1919564..1919938) similar to uniprot|Q06333 YDR357C Saccharomyces cerevisiae Protein of unknown function KLLA0E21517g 0 1920040 1922616 ON 5 E21517 complement(1920040..1922616) similar to uniprot|Q756L3 Ashbya gossypii AER241W AER241Wp and weakly similar to YDR356W uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component ortholog of human kendrin involved in connecting nuclear microtubules to SPB interacts with Tub4p-complex and calmodulin phosphorylated by Mps1p in cell cycle-dependent manner KLLA0E21539g 0 1923103 1924305 ON 5 E21539 complement(1923103..1924305) similar to uniprot|P38347 YBR271W Saccharomyces cerevisiae Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0E21561g 0 1924493 1925581 ON 5 E21561 complement(1924493..1925581) similar to uniprot|P07285 YDR354W Saccharomyces cerevisiae TRP4 anthranilate phosphoribosyl transferase KLLA0E21583g 1 1926061 1927245 ON 5 E21583 (1926061..1927245) similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM KLLA0E21605g 0 1927687 1928736 ON 5 E21605 complement(1927687..1928736) highly similar to uniprot|P29509 YDR353W Saccharomyces cerevisiae TRR1 Thioredoxin reductase KLLA0E21627g 0 1929294 1930283 ON 5 E21627 complement(1929294..1930283) highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal d-xylose and arabinose metabolism stress induced (osmotic ionic oxidative heat shock starvation and heavy metals) regulated by the HOG pathway KLLA0E21649g 0 1931058 1932017 ON 5 E21649 complement(1931058..1932017) similar to uniprot|Q06328 YDR352w Saccharomyces cerevisiae Hypothetical ORF KLLA0E21671g 0 1932604 1935069 ON 5 E21671 complement(1932604..1935069) similar to uniprot|P38814 YHR103W Saccharomyces cerevisiae SBE Protein involved in the transport of cell wall components from the Golgi to the cell surface KLLA0E21693g 0 1936438 1939488 ON 5 E21693 complement(1936438..1939488) weakly similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 kinase family required for cell integrity possibly through regulating 1 6-beta-glucan levels in the wall physically interacts with Cdc31p (centrin) which is a component of the spindle pole body KLLA0E21715g 1 1940144 1942279 ON 5 E21715 (1940144..1942279) weakly similar to uniprot|P50273 YDR350C Saccharomyces cerevisiae CM10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase KLLA0E21737g 1 1942411 1943651 ON 5 E21737 (1942411..1942424,1942793..1943651) weakly similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum required for normal content of cell wall beta-1 6-glucan KLLA0E21759g 1 1943933 1944760 ON 5 E21759 (1943933..1944760) similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole controls entry of biosynthetic endocytic and retrograde traffic into the prevacuolar compartment syntaxin KLLA0E21781g 0 1944865 1945866 ON 5 E21781 complement(1944865..1945866) similar to uniprot|Q05583 YDR267C Saccharomyces cerevisiae CIA1 Protein required for cell viability KLLA0E21803g 1 1946190 1947263 ON 5 E21803 (1946190..1947263) similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial protein required for normal abundance of mitochondrial cytochrome c (Cyc1p) and for mitochondrial osmotic stability may be involved in regulating the activity of cytochrome c heme lyase (Cyc3p) potential Cdc28p substrate KLLA0E21825g 1 1947496 1948632 ON 5 E21825 (1947496..1948632) similar to uniprot|P04803 YDR268W Saccharomyces cerevisiae MSW1 Mitochondrial tryptophanyl-tRNA synthetase KLLA0E21847g 0 1948687 1951230 ON 5 E21847 complement(1948687..1951230) similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A H2B H3 and H4 genes recruits Swi-Snf complexes to histone gene promoters promotes heterochromatic gene silencing with Asf1p KLLA0E21869g 1 1951763 1952545 ON 5 E21869 (1951763..1952545) similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 protein kinase CK2 beta' subunit KLLA0E21891g 1 1954118 1955761 ON 5 E21891 (1954118..1955761) similar to uniprot|P40215 Saccharomyces cerevisiae YMR145C NDE1 Mitochondrial external NADH dehydrogenase KLLA0E21913g 1 1958004 1959410 ON 5 E21913 (1958004..1959410) conserved hypothetical protein KLLA0E21935g 1 1959770 1961083 ON 5 E21935 (1959770..1961083) highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Suppresses the cold-sensitive snRNP biogenesis brr1-1 mutation RNA helicase KLLA0E21957g 0 1961626 1962786 ON 5 E21957 complement(1961626..1962786) weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Hypothetical ORF KLLA0E21979g 0 1963506 1964516 ON 5 E21979 complement(1963506..1963913,1964493..1964516) highly similar to uniprot|P40213 Saccharomyces cerevisiae YMR143w RPS16A or uniprot|P40213 Saccharomyces cerevisiae YDL083c RPS16B KLLA0E22001g 1 1965666 1966857 ON 5 E22001 (1965666..1965669,1966262..1966857) highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082w RPL13A ribosomal protein or uniprot|P40212 Saccharomyces cerevisiae YMR142c RPL13B KLLA0E22023g 0 1967315 1967635 ON 5 E22023 complement(1967315..1967635) highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal protein P1 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component KLLA0E22045g 0 1968293 1969744 ON 5 E22045 complement(1968293..1969744) similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Sip5p facilitates the interaction between the Glc7p phosphatase and the Snf1p kinase KLLA0E22089g 0 1970992 1972404 ON 5 E22089 complement(1970992..1972404) weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine KLLA0E22111g 1 1973522 1974187 ON 5 E22111 (1973522..1974187) similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein of unknown function found in both the cytoplasm and nucleus KLLA0E22133g 0 1974635 1975786 ON 5 E22133 complement(1974635..1975786) similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23 KLLA0E22155g 0 1976362 1977714 ON 5 E22155 complement(1976362..1977714) similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Mannan 8 Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol subunit of mannosyltransferase complex KLLA0E22177g 1 1978388 1978777 ON 5 E22177 (1978388..1978777) no similarity KLLA0E22199g 1 1979344 1979817 ON 5 E22199 (1979344..1979817) highly similar to uniprot|P19211 Saccharomyces cerevisiae ANB1 Translation initiation factor eIF-5A, and to YEL034W uniprot|P23301 Saccharomyces cerevisiae YEL034W HYP2 Translation initiation factor eIF-5A Klac_5.trna18S 1 1980854 1980935 ON 5 tS-AGA (1980854..1980935) tRNA Type: Ser (S) | Anti-Codon: AGA | Cove Score: 82.65 KLLA0E22243g 1 1981275 1984070 ON 5 E22243 (1981275..1984070) similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex KLLA0E22265g 1 1984522 1988142 ON 5 E22265 (1984522..1988142) highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa P-type ATPase KLLA0E22287g 0 1988282 1989994 ON 5 E22287 complement(1988282..1989994) similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 (DNA replication) KLLA0E22309g 1 1990670 1992595 ON 5 E22309 (1990670..1992595) highly similar to uniprot|P12398 Saccharomyces cerevisiae YJR045C KLLA0E22331g 1 1993214 1993642 ON 5 E22331 (1993214..1993642) similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Vacuolar Protein Sorting YJR044c Klac_5.trna19Q 0 1993879 1993950 ON 5 tQ-UUG complement(1993879..1993950) tRNA Type: Gln (Q) | Anti-Codon: UUG | Cove Score: 71.46 KLLA0E22375g 0 1994296 1995234 ON 5 E22375 complement(1994296..1995234) similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C KLLA0E22397g 1 1996893 1997771 ON 5 E22397 (1996893..1997771) conserved hypothetical protein KLLA0E22419g 1 1998187 1999356 ON 5 E22419 (1998187..1999356) weakly similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta involved in chromosomal DNA replication required for error-prone DNA synthesis in the presence of DNA damage and processivity interacts with Pol31p PCNA (Pol30p) and Pol1p KLLA0E22441g 1 2000055 2000537 ON 5 E22441 (2000055..2000537) similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W CUP5 Proteolipid subunit of the vacuolar H( )- ATPase V0 sector required for vacuolar acidification and important for copper and iron metal ion homeostasis KLLA0E22463g 0 2001004 2003178 ON 5 E22463 complement(2001004..2003178) similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking KLLA0E22485g 1 2003803 2007237 ON 5 E22485 (2003803..2007237) similar to uniprot|Q757T4 Ashbya gossypii AEL072W AEL072Wp and weakly similar to YJR041C uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript proposed to be involved in ribosome biogenesis KLLA0E22507g 0 2007287 2009557 ON 5 E22507 complement(2007287..2009557) similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Chloride channel localized to late- or post- Golgi vesicles involved in iron metabolism highly homologous to voltage-gated chloride channels in vertebrates KLLA0E22529g 1 2010162 2010542 ON 5 E22529 (2010162..2010542) highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri- snRNP involved in mRNA splicing, similar to human 15.5K protein KLLA0E22551g 1 2011000 2013420 ON 5 E22551 (2011000..2013420) similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability KLLA0E22573g 1 2014172 2014813 ON 5 E22573 (2014172..2014813) highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex KLLA0E22595g 0 2015938 2017968 ON 5 E22595 complement(2015938..2017968) similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Hypothetical ORF KLLA0E22617g 0 2018248 2021349 ON 5 E22617 complement(2018248..2021349) similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions homolog of human CSB protein Klac_5.trna20P 0 2021684 2021805 ON 5 tP-UGG complement(2021684..2021719,2021770..2021805) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 60.08 KLLA0E22661g 0 2022425 2022751 ON 5 E22661 complement(2022425..2022751) highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase KLLA0E22683g 1 2023109 2027200 ON 5 E22683 (2023109..2027200) weakly similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p Rav2p Skp1p) which promotes assembly of the V-ATPase holoenzyme required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins potential Cdc28p substrate KLLA0E22705g 0 2027229 2028398 ON 5 E22705 complement(2027229..2028398) similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity KLLA0E22727g 1 2028791 2032954 ON 5 E22727 (2028791..2032954) similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W KLLA0E22749g 0 2033077 2034387 ON 5 E22749 complement(2033077..2034387) conserved hypothetical protein KLLA0E22771g 1 2034995 2035798 ON 5 E22771 (2034995..2035798) highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 orotidine-5'-phosphate decarboxylase KLLA0E22793g 1 2036117 2036380 ON 5 E22793 (2036117..2036380) highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins KLLA0E22859g 0 2037327 2038079 ON 5 E22859 complement(2037327..2038079) similar to uniprot|Q754L8 Ashbya gossypii AFR054W AFR054Wp and weakly similar to YNL148C uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 alpha-tubulin foldin protein implicated in folding of alpha tubulin cofactor B KLLA0E22881g 1 2038281 2038743 ON 5 E22881 (2038281..2038292,2038423..2038743) highly similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay KLLA0E22903g 1 2039283 2039936 ON 5 E22903 (2039283..2039936) highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase synthesizes UMP from uracil involved in the pyrimidine salvage pathway KLLA0E22925g 0 2040279 2041421 ON 5 E22925 complement(2040279..2041421) similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex required for spindle orientation and nuclear migration putative ortholog of mammalian centractin KLLA0E22947g 0 2041663 2043489 ON 5 E22947 complement(2041663..2043489) conserved hypothetical protein Klac_YGOB_YNL146W 1 2043882 2044172 ON 5 YNL146W (2043882..2044172) ANNOTATED BY YGOB - KLLA0E22969g 0 2044323 2046779 ON 5 E22969 complement(2044323..2046779) similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C Hypothetical ORF KLLA0E22991g 0 2047913 2049145 ON 5 E22991 complement(2047913..2049145) similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1 2-mannosyltransferase involved in O- and N-linked protein glycosylation member of the KRE2/MNT1 mannosyltransferase family KLLA0E23013g 0 2049719 2050726 ON 5 E23013 complement(2049719..2050726) some similarities with uniprot|P53324 Saccharomyces cerevisiae YGR263C KLLA0E23035g 1 2051146 2052123 ON 5 E23035 (2051146..2052123) weakly similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C Hypothetical ORF KLLA0E23057g 0 2052418 2053941 ON 5 E23057 complement(2052418..2053941) highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase that is activated by Mg2 and utilizes NADP as the preferred coenzyme KLLA0E23079g 0 2056949 2059129 ON 5 E23079 complement(2056949..2059129) weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for wild-type resistance to the antifungal drug ciclopirox olamine not related to the COS family of subtelomerically-encoded proteins KLLA0E23101g 0 2059506 2060948 ON 5 E23101 complement(2059506..2060948) similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Protein of the inner mitochondrial membrane required for import of mitochondrial matrix proteins KLLA0E23123g 0 2061320 2062060 ON 5 E23123 complement(2061320..2062060) similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex which is involved in ubiquitin-dependent sorting of proteins into the endosome involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole KLLA0E23145g 0 2062230 2063543 ON 5 E23145 complement(2062230..2063543) similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Hypothetical ORF KLLA0E23167g 1 2064516 2065583 ON 5 E23167 (2064516..2065583) similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase) involved in purine salvage and nitrogen catabolism KLLA0E23189g 0 2065845 2068325 ON 5 E23189 complement(2065845..2068325) similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W CDC47 Component of the hexameric MCM complex which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase KLLA0E23211g 1 2069647 2069919 ON 5 E23211 (2069647..2069919) weakly similar to uniprot|Q2V2Q3 Saccharomyces cerevisiae YBR201C-A KLLA0E23233g 1 2070261 2070881 ON 5 E23233 (2070261..2070881) weakly similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Hypothetical ORF KLLA0E23255g 1 2071111 2072031 ON 5 E23255 (2071111..2072031) weakly similar to uniprot|Q02749 Saccharomyces cerevisiae YPL068C KLLA0E23277g 0 2072151 2072720 ON 5 E23277 complement(2072151..2072720) weakly similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein required for the protein degradation process associated with the ER involved in the retrograde transport of misfolded or unassembled proteins KLLA0E23299g 1 2073218 2074165 ON 5 E23299 (2073218..2074165) similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase increases the intracellular pool of geranylgeranyl diphosphate suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic KLLA0E23321g 0 2074221 2075762 ON 5 E23321 complement(2074221..2075762) weakly similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Protein of unknown function localized to the cytoplasm computational analysis of large- scale protein-protein interaction data suggests a possible role in transcriptional regulation KLLA0E23343g 1 2076232 2076762 ON 5 E23343 (2076232..2076762) similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Hypothetical ORF KLLA0E23365g 0 2077042 2078987 ON 5 E23365 complement(2077042..2078760,2078979..2078987) similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains involved in establishing cell polarity and morphogenesis functions as a scaffold protein for complexes that include Cdc24p Ste5p Ste20p and Rsr1p KLLA0E23387g 0 2079405 2081753 ON 5 E23387 complement(2079405..2081753) some similarities with uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Putative ubiquitin-specific protease KLLA0E23409g 0 2082115 2084106 ON 5 E23409 complement(2082115..2084106) similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family localized to the cortex of mother cells but not to daughter cells KLLA0E23431g 0 2084504 2086807 ON 5 E23431 complement(2084504..2086807) uniprot|Q9C4B2 Kluyveromyces lactis KLLA0E23507g KlGCR1 KLLA0E23453g 1 2088516 2090996 ON 5 E23453 (2088516..2090996) similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes involved in RNA polymerase II transcription initiation and in chromatin modification KLLA0E23475g 0 2091184 2092002 ON 5 E23475 complement(2091184..2092002) similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N- acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors homologous to the human PIG-C protein KLLA0E23497g 1 2092311 2092706 ON 5 E23497 (2092311..2092706) some similarities with uniprot|Q02831 Saccharomyces cerevisiae YPL077C KLLA0E23519g 1 2093243 2094910 ON 5 E23519 (2093243..2094910) highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase catalyzes the interconversion of glucose-6- phosphate and fructose-6-phosphate required for cell cycle progression and completion of the gluconeogenic events of sporulation KLLA0E23541g 1 2095246 2096499 ON 5 E23541 (2095246..2096499) similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF- I) regulates the RAS/cAMP pathway via sequestration of Npr1p kinase localizes to the nucleus and cytoplasm homologous to human retinoblastoma binding proteins RbAp48 and RbAp46 KLLA0E23563g 1 2097204 2097917 ON 5 E23563 (2097204..2097917) uniprot|O13349 Kluyveromyces lactis ATP4 ATP synthase subunit 4 mitochondrial precursor KLLA0E23585g 0 2098486 2098849 ON 5 E23585 complement(2098486..2098784,2098843..2098849) weakly similar to uniprot|P38305 Saccharomyces cerevisiae YBR194W SOY1 Synthetic with Old Yellow Enzyme KLLA0E23607g 1 2099005 2099715 ON 5 E23607 (2099005..2099715) similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex KLLA0E23629g 0 2099965 2101071 ON 5 E23629 complement(2099965..2101071) highly similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Protein of the mitochondrial carrier (MCF) family that is required for respiration Probable carrier protein mitochondrial KLLA0E23651g 0 2101642 2102666 ON 5 E23651 complement(2101642..2102113,2102656..2102666) highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W KLLA0E23673g 0 2103729 2104885 ON 5 E23673 complement(2103729..2104288,2104879..2104885) highly similar to uniprot|O13516 Saccharomyces cerevisiae YPL081W RPS9A and to uniprot|P05755 Saccharomyces cerevisiae YBR189W RPS9B Proteins component of the small (40S) ribosomal subunit KLLA0E23695g 0 2105401 2106582 ON 5 E23695 complement(2105401..2106582) highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase KLLA0E23717g 1 2108059 2113680 ON 5 E23717 (2108059..2113680) similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription removes Spt15p (TBP) from DNA via its C-terminal ATPase activity forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity KLLA0E23739g 1 2113963 2114244 ON 5 E23739 (2113963..2114244) no similarity KLLA0E23761g 0 2114375 2115202 ON 5 E23761 complement(2114375..2115202) similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W Hypothetical ORF KLLA0E23783g 0 2115721 2117484 ON 5 E23783 complement(2115721..2115885,2115988..2117484) weakly similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint which prevents chromosome segregation when recombination and chromosome synapsis are defective also represses meiotic interhomolog recombination in the rDNA KLLA0E23805g 0 2118234 2118512 ON 5 E23805 complement(2118234..2118512) no similarity Klac_5.trna21E 1 2119065 2119136 ON 5 tE-UUC (2119065..2119136) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0E23849g 1 2119396 2120718 ON 5 E23849 (2119396..2120718) similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p KLLA0E23871g 0 2120757 2123198 ON 5 E23871 complement(2120757..2123198) similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes KLLA0E23893g 1 2123599 2124411 ON 5 E23893 (2123599..2124411) similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Protein involved in assembly of mitochondrial respiratory complexes may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane KLLA0E23915g 0 2124622 2130870 ON 5 E23915 complement(2124622..2130870) weakly similar to uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding and autophagosome formation Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes interacts with Sec23p Sec24p and Sec31p KLLA0E23937g 1 2131460 2133145 ON 5 E23937 (2131460..2133145) highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Histone acetyltransferase subunit of the Elongator complex which is a component of the RNA polymerase II holoenzyme activity is directed specifically towards histones H3 and H4 disruption confers resistance to K. lactis zymotoxin KLLA0E23959g 0 2133281 2134462 ON 5 E23959 complement(2133281..2134462) similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis KLLA0E23981g 0 2134891 2135856 ON 5 E23981 complement(2134891..2135856) similar to uniprot|P38298 Saccharomyces cerevisiae YBR183W YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity catalyzes both breakdown and synthesis of phytoceramide overexpression confers fumonisin B1 resistance KLLA0E24003g 0 2136583 2137425 ON 5 E24003 complement(2136583..2137425) conserved hypothetical protein KLLA0E24025g 1 2138785 2140983 ON 5 E24025 (2138785..2140983) some similarities with uniprot|P38128 Saccharomyces cerevisiae YBR182C SMP1 Transcription factor of the MADS (Mcm1p Agamous Deficiens SRF) box family closely related to RLM1 Probable DNA-binding transcription factor Homolog to SRF/SL-2 KLLA0E24047g 1 2142144 2143416 ON 5 E24047 (2142144..2142149,2142712..2143416) highly similar to uniprot|P02365 Saccharomyces cerevisiae YPL090C RPS6A and to uniprot|P02365 Saccharomyces cerevisiae YBR181C RPS6B Proteins component of the small (40S) ribosomal subunit KLLA0E24069g 0 2143697 2145151 ON 5 E24069 complement(2143697..2145151) highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase converts oxidized glutathione to reduced glutathione KLLA0E24091g 0 2145749 2147089 ON 5 E24091 complement(2145749..2147089) similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump KLLA0E24113g 0 2148115 2149842 ON 5 E24113 complement(2148115..2149842) similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Multidrug resistance dityrosine transporter of the major facilitator superfamily essential for spore wall synthesis facilitates the translocation of bisformyl dityrosine through the prospore membrane KLLA0E24135g 0 2150759 2152690 ON 5 E24135 complement(2150759..2152690) highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis member of the ODN family of nucleolar G-proteins KLLA0E24157g 1 2153311 2154051 ON 5 E24157 (2153311..2154051) similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C KLLA0E24179g 1 2154452 2156929 ON 5 E24179 (2154452..2156929) similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome contains N-terminal GTPase domain KLLA0E24201g 1 2157376 2158725 ON 5 E24201 (2157376..2158725) similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C EHT1 Possible serine hydrolase and similar to uniprot|Q02891 Saccharomyces cerevisiae YPL095C KLLA0E24223g 0 2158824 2159885 ON 5 E24223 complement(2158824..2159885) similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 de-N-glycosylation enzyme peptide:N- glycanase KLLA0E24245g 1 2160073 2160354 OFF 5 E24245 (2160073..2160354) no similarity Klac_YGOB_Anc_8.576 1 2160245 2160496 ON 5 Anc_8.576 (2160245..2160496) ANNOTATED BY YGOB - KLLA0E24267g 0 2160623 2161984 ON 5 E24267 complement(2160623..2161984) similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W KLLA0E24289g 1 2162312 2162674 ON 5 E24289 (2162312..2162674) similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C Hypothetical ORF KLLA0E24311g 1 2162999 2163475 ON 5 E24311 (2162999..2163475) similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C FMP14 The authentic non-tagged protein was localized to the mitochondria KLLA0E24333g 0 2163651 2164829 ON 5 E24333 complement(2163651..2164829) similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphatidylinositol 3 5-bisphosphate- binding protein required for maturation of pro- aminopeptidase I predicted to fold as a seven-bladed beta- propeller displays punctate cytoplasmic localization KLLA0E24355g 0 2165178 2166614 ON 5 E24355 complement(2165178..2166614) similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Elongator protein part of the HAP subcomplex of Elongator which is a six-subunit component of the RNA polymerase II holoenzyme required for Elongator structural integrity and histone acetyltransferase activity KLLA0E24377g 1 2167004 2168338 ON 5 E24377 (2167004..2168338) similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C KLLA0E24399g 0 2168378 2169334 ON 5 E24399 complement(2168378..2169334) similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase required for pantothenic acid biosynthesis converts 2- oxoisovalerate into 2-dehydropantoate KLLA0E24421g 1 2171139 2172245 ON 5 E24421 (2171139..2172245) similar to gnl|GLV|CAGL0K04015g Candida glabrata CAGL0K04015g and weakly similar to YGR031W uniprot|P53219 Saccharomyces cerevisiae YGR031W Hypothetical ORF KLLA0E24443g 1 2172817 2173449 ON 5 E24443 (2172817..2173449) no similarity KLLA0E24465g 0 2173560 2175497 ON 5 E24465 complement(2173560..2175497) similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene KLLA0E24487g 0 2175775 2176758 ON 5 E24487 complement(2175775..2176758) similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres KLLA0E24509g 1 2177223 2177669 ON 5 E24509 (2177223..2177669) highly similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome degraded by proteasome upon completion of its assembly involved in ubiquitin-mediated proteolysis mutant defective in degradation of short-lived proteins KLLA0E24531g 1 2178343 2180724 ON 5 E24531 (2178343..2180724) weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C SMY2 partial suppressor of myo2-66 Kinesin-related protein suppressing myosin defects (MYO2) and to uniprot|Q02875 YPL105c KLLA0E24553g 0 2180838 2181446 ON 5 E24553 complement(2180838..2181446) similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p Sec62p Sec66p and Sec72p) with Sec61 complex Kar2p/BiP and Lhs1p forms a channel competent for SRP- dependent and post-translational SRP-independent protein targeting and import into the ER KLLA0E24575g 1 2181790 2183580 ON 5 E24575 (2181790..2183580) similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Endoplasmic reticulum and nuclear membrane protein forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation KLLA0E24597g 1 2183993 2186077 ON 5 E24597 (2183993..2186077) highly similar to uniprot|P32589 Saccharomyces cerevisiae YPL106C SSE1 HSP70 family member highly homologous to Ssa1p and Sse2p KLLA0E24619g 0 2186375 2187091 ON 5 E24619 complement(2186375..2187091) similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Hypothetical ORF KLLA0E24641g 0 2187515 2188663 ON 5 E24641 complement(2187515..2188663) similar to uniprot|Q74ZI7 Ashbya gossypii AGR215C AGR215Cp and weakly similar to YBR168W uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein involved in negative regulation of peroxisome size partially functionally redundant with Pex31p genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p KLLA0E24663g 1 2188906 2189316 ON 5 E24663 (2188906..2189316) similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0E24685g 0 2189395 2189949 ON 5 E24685 complement(2189395..2189949) similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Hypothetical ORF KLLA0E24707g 0 2190120 2190740 ON 5 E24707 complement(2190120..2190740) similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation expression sensitive to nitrogen catabolite repression KLLA0E24729g 1 2191359 2192696 ON 5 E24729 (2191359..2192696) similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Step of tyrosine biosynthesis pathway Prephenate dehydrogenase (NADP ) KLLA0E24751g 0 2192929 2193660 ON 5 E24751 complement(2192929..2193660) weakly similar to uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity KLLA0E24773g 1 2194554 2195105 ON 5 E24773 (2194554..2195105) highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP- ribosylation factor KLLA0E24795g 1 2195975 2197783 ON 5 E24795 (2195975..2197783) similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Hypothetical ORF KLLA0E24817g 1 2197875 2198108 ON 5 E24817 (2197875..2198108) conserved hypothetical protein KLLA0E24861g 0 2203694 2204362 ON 5 E24861 complement(2203694..2204362) some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization KLLA0E24883g 1 2205689 2207464 ON 5 E24883 (2205689..2207464) weakly similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C Hypothetical ORF KLLA0E24905g 0 2207777 2208331 ON 5 E24905 complement(2207777..2208331) some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein linked to a beta-1 3- and beta-1 6-glucan heteropolymer through a phosphodiester bond involved in cell wall organization KLLA0E24927g 1 2209545 2210519 ON 5 E24927 (2209545..2210519) no similarity KLLA0E24949g 1 2212047 2213501 ON 5 E24949 (2212047..2213501) similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin KLLA0E24993g 0 2214864 2216570 ON 5 E24993 complement(2214864..2216570) similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA) localized to the vacuolar membrane KLLA0E25015g 0 2219051 2220721 ON 5 E25015 complement(2219051..2220721) weakly similar to uniprot|P32465 Saccharomyces cerevisiae YHR094C HXT1 Low-affinity glucose transporter of the major facilitator superfamily KLLA0E25081g 1 2222708 2224600 ON 5 E25081 (2222708..2224600) similar to uniprot|P07337 Kluyveromyces marxianus Beta- glucosidase precursor KLLA0E25147g 1 2227131 2228147 ON 5 E25147 (2227131..2228147) some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C KLLA0E25180g 0 2229939 2231063 ON 5 E25180 complement(2229939..2231063) Retrotransposon Gag gene KLLA0F00132g 1 2473 3519 ON 6 F00132 (2473..3519) conserved hypothetical protein KLLA0F00154g 1 4320 5843 ON 6 F00154 (4320..5843) similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0F00176g 0 6530 6748 ON 6 F00176 complement(6530..6748) no similarity KLLA0F00220g 1 7833 8273 ON 6 F00220 (7833..8273) no similarity KLLA0F00242g 1 8992 10260 ON 6 F00242 (8992..10260) similar to uniprot|Q06598 Saccharomyces cerevisiae YPR201W ARR3 Arsenite transporter of the plasma membrane required for resistance to arsenic compounds transcription is activated by Arr1p in the presence of arsenite KLLA0F00264g 1 12724 13659 ON 6 F00264 (12724..13659) similar to uniprot|P40100 Saccharomyces cerevisiae YER185W Hypothetical ORF and to YGR213C uniprot|P53047 Saccharomyces cerevisiae YGR213C RTA1 involved in 7- aminocholesterol resistance KLLA0F00286g 1 14519 16138 ON 6 F00286 (14519..16138) similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W Hypothetical ORF KLLA0F00308g 0 17067 17537 ON 6 F00308 complement(17067..17537) weakly similar to uniprot|P39718 Saccharomyces cerevisiae YAL055W PEX22 KLLA0F00330g 1 17682 18794 ON 6 F00330 (17682..18794) similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein involved in the activation of the DNA damage and meiotic pachytene checkpoints with Mec3p and Ddc1p forms a clamp that is loaded onto partial duplex DNA homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins KLLA0F00352g 0 19046 19450 ON 6 F00352 complement(19046..19450) similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C RPS12 Protein component of the small (40S) ribosomal subunit KLLA0F00374g 0 20124 22511 ON 6 F00374 complement(20124..22511) weakly similar to uniprot|Q08886 Saccharomyces cerevisiae YOR371C GPB1 Proposed beta subunit of the heterotrimeric G protein that interacts with the receptor Grp1p has signaling role in response to nutrients involved in regulation of pseudohyphal growth through cAMP levels homolog of Gpb2p KLLA0F00396g 0 23088 24740 ON 6 F00396 complement(23088..24740) weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division KLLA0F00418g 1 26773 29505 ON 6 F00418 (26773..29505) weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque required for exit from mitosis KLLA0F00440g 1 31019 32587 ON 6 F00440 (31019..32587) highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase that utilizes NADP or NAD equally as coenzymes expression is glucose repressed KLLA0F00462g 0 33094 34980 ON 6 F00462 complement(33094..34980) some similarities with uniprot|P27825 Saccharomyces cerevisiae YAL058W CNE1 KLLA0F00484g 0 35333 35929 ON 6 F00484 complement(35333..35929) similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Protein of unknown function localized in the nucleoplasm and the nucleolus genetically interacts with MTR2 in 60S ribosomal protein subunit export KLLA0F00506g 0 36518 37675 ON 6 F00506 complement(36518..37675) similar to uniprot|P39714 Saccharomyces cerevisiae YAL060W BDH1 NAD-dependent (2R 3R)-2 3-butanediol dehydrogenase KLLA0F00528g 0 40081 41226 ON 6 F00528 complement(40081..41226) similar to uniprot|P39713 Saccharomyces cerevisiae YAL061W putative polyol dehydrogenase KLLA0F00572g 0 42710 44503 ON 6 F00572 complement(42710..44503) conserved hypothetical protein KLLA0F00594g 0 45305 46690 ON 6 F00594 complement(45305..46690) highly similar to uniprot|P07262 Saccharomyces cerevisiae and to YAL062W uniprot|P39708 Saccharomyces cerevisiae, GDH3 NADP(+)-dependent glutamate dehydrogenase KLLA0F00616g 1 48832 50748 ON 6 F00616 (48832..50748) some similarities with uniprot|Q12473 Saccharomyces cerevisiae YLL051C KLLA0F00638g 1 51849 52997 ON 6 F00638 (51849..52997) weakly similar to uniprot|P53912 Saccharomyces cerevisiae or YLR460C uniprot|P54007 Saccharomyces cerevisiae YLR460C Hypothetical ORFs KLLA0F00660g 1 54232 58356 ON 6 F00660 (54232..58356) similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C Hypothetical ORF KLLA0F00682g 0 58631 59137 ON 6 F00682 complement(58631..59137) conserved hypothetical protein KLLA0F00704g 0 60425 61384 ON 6 F00704 complement(60425..61384) similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase KLLA0F00726g 1 62828 64123 ON 6 F00726 (62828..64123) similar to uniprot|Q6B2A9 Saccharomyces cerevisiae YPL112C PEX25 Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance recruits GTPase Rho1p to peroxisomes induced by oleate interacts with homologous protein Pex27p KLLA0F00748g 0 64529 65218 ON 6 F00748 complement(64529..65218) similar to uniprot|Q74ZW6 Ashbya gossypii AGR228C and weakly similar to YOR194C uniprot|P32773 Saccharomyces cerevisiae TOA1 Transcription factor IIA large chain KLLA0F00770g 1 65967 67853 ON 6 F00770 (65967..67853) some similarities with uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis KLLA0F00792g 1 68605 69786 ON 6 F00792 (68605..69786) similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Putative dehydrogenase KLLA0F00814g 1 70536 73673 ON 6 F00814 (70536..73673) similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization KLLA0F00836g 0 73932 75044 ON 6 F00836 complement(73932..75044) highly similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C LIP5 Protein involved in biosynthesis of the coenzyme lipoic acid KLLA0F00843g 1 75779 76075 ON 6 F00843 (75779..76075) no similarity KLLA0F00858g 0 78519 80666 ON 6 F00858 complement(78519..80666) similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) KLLA0F00880g 1 81734 83035 ON 6 F00880 (81734..83035) similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases KLLA0F00902g 0 83326 84729 ON 6 F00902 complement(83326..84729) similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes KLLA0F00924g 1 85633 86469 ON 6 F00924 (85633..86469) highly similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase KLLA0F00946g 0 86695 87897 ON 6 F00946 complement(86695..87897) similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical nucleotide in mitochondrial 21S rRNA KLLA0F00968g 1 88262 88927 ON 6 F00968 (88262..88927) highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphate dehydratase KLLA0F00990g 0 89152 90210 ON 6 F00990 complement(89152..90210) similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the large subunit MRP51 KLLA0F01012g 0 90772 92442 ON 6 F01012 complement(90772..92442) similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C GNP1 High-affinity glutamine permease also transports Leu Ser Thr Cys Met and Asn KLLA0F01034g 1 93422 95305 ON 6 F01034 (93422..95305) similar to uniprot|P06634 Saccharomyces cerevisiae YOR204W DED1 ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase required for translation initiation of all yeast mRNAs KLLA0F01056g 0 96166 97656 ON 6 F01056 complement(96166..97656) similar to uniprot|Q02939 Saccharomyces cerevisiae YPL122C TFB2 subunit of TFIIH and nucleotide excision repair factor 3 complexes KLLA0F01078g 1 98331 101759 ON 6 F01078 (98331..101759) highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 second-largest subunit of RNA polymerase III KLLA0F01100g 0 101843 102499 ON 6 F01100 complement(101843..102499) similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1- dependent meiotic recombination KLLA0F01122g 0 102765 104903 ON 6 F01122 complement(102765..104903) similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes as well as a nuclear complex with Noc3p that binds to 66S pre- ribosomes both complexes mediate intranuclear transport of ribosomal precursors KLLA0F01144g 1 105169 106983 ON 6 F01144 (105169..106983) similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C FMP38 The authentic non-tagged protein was localized to the mitochondria KLLA0F01166g 1 107298 108683 ON 6 F01166 (107298..108683) similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Protein required for sorting and delivery of soluble hydrolases to the vacuole KLLA0F01188g 1 109136 111703 ON 6 F01188 (109136..111703) highly similar to uniprot|P21524 Saccharomyces cerevisiae YER070W RNR1 Ribonucleotide-diphosphate reductase (RNR) and to YIL066C uniprot|P21672 Saccharomyces cerevisiae YIL066C RNR3 Ribonucleotide- diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits KLLA0F01210g 1 112835 114331 ON 6 F01210 (112835..114331) similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Serine hydroxymethyltransferase mitochondrial KLLA0F01232g 0 114430 115062 ON 6 F01232 complement(114430..115062) similar to uniprot|P36019 Saccharomyces cerevisiae YNL093W YPT53 Involved in vacuolar protein sorting and endocytosis GTP-binding protein of the rab family KLLA0F01254g 1 115485 119945 ON 6 F01254 (115485..119945) weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C- terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing deletion results in telomere elongation KLLA0F01276g 0 120001 121560 ON 6 F01276 complement(120001..121560) similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 checkpoint kinase 1 KLLA0F01298g 1 121988 123169 ON 6 F01298 (121988..123169) similar to uniprot|P38349 Saccharomyces cerevisiae YBR273C UBX7 UBX (ubiquitin regulatory X) domain- containing protein that interacts with Cdc48p KLLA0F01320g 0 123277 124602 ON 6 F01320 complement(123277..124602) weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Hypothetical ORF KLLA0F01342g 1 124864 126273 ON 6 F01342 (124864..126273) similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C KLLA0F01364g 0 126312 129533 ON 6 F01364 complement(126312..129533) highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 Dead-box family ATP dependent helicase required for mRNA export from the nucleus co- factor of the exosome complex required for 3' end formation of 5.8S rRNA KLLA0F01386g 0 132122 134323 ON 6 F01386 complement(132122..134323) weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W Protein of unknown function localized to the bud tip mRNA is targeted to the bud via the mRNA transport system involving She2p KLLA0F01408g 1 135424 136302 ON 6 F01408 (135424..136302) conserved hypothetical protein KLLA0F01419g 0 136295 137209 ON 6 F01419 complement(136295..137209) highly similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex KLLA0F01441g 0 137575 138990 ON 6 F01441 complement(137575..138990) weakly similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Translocase Inner Membrane 54kD Translocase for the insertion of proteins into the mitochondrial inner membrane KLLA0F01463g 1 140343 142688 ON 6 F01463 (140343..142688) some similarities with uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc regulates its own transcription contains seven zinc- finger domains KLLA0F01485g 0 143345 143830 ON 6 F01485 complement(143345..143830) weakly similar to uniprot|Q02486 Saccharomyces cerevisiae YMR072W ABF2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination member of HMG1 DNA-binding protein family activity may be regulated by protein kinase A phosphorylation KLLA0F01507g 1 144356 145774 ON 6 F01507 (144356..145774) some similarities with uniprot|P47042 Saccharomyces cerevisiae YJL057C probable serine/threonine kinase KLLA0F01529g 1 145940 146662 ON 6 F01529 (145940..146662) some similarities with uniprot|P38346 Saccharomyces cerevisiae YBR270C BIT2 Hypothetical ORF KLLA0F01551g 0 146711 147874 ON 6 F01551 complement(146711..147874) similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Homolog of human CLN3 vacuolar/lysosomal membrane protein KLLA0F01573g 1 148328 149113 ON 6 F01573 (148328..149113) no similarity KLLA0F01595g 1 151557 153518 ON 6 F01595 (151557..153518) weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)- anchored cell wall endoglucanase required for proper cell separation after cytokinesis expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner KLLA0F01617g 0 154025 155359 ON 6 F01617 complement(154025..155359) highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Arylformamidase KLLA0F01639g 1 156067 156462 ON 6 F01639 (156067..156462) similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 The authentic non-tagged protein was localized to the mitochondria KLLA0F01661g 0 156609 158672 ON 6 F01661 complement(156609..158672) weakly similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Subunit of the nuclear pore complex (NPC) forms a subcomplex with Nup159p and Nsp1p interacts with Nup116p and is required for proper localization of Nup116p in the NPC KLLA0F01683g 0 158967 159263 ON 6 F01683 complement(158967..159263) similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit KLLA0F01705g 0 159469 161832 ON 6 F01705 complement(159469..161832) similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure mutations affect cell wall integrity KLLA0F01727g 0 162226 163440 ON 6 F01727 complement(162226..163440) similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Protein of unknown function involved in bud growth in the mitotic signaling network proposed negative regulator of Swe1p and Gin4p contains dispersed C2H2 zinc finger domains KLLA0F01749g 0 163821 164762 ON 6 F01749 complement(163821..164762) similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 catalyzes the second step in the synthesis of phytosphingosine 3-ketosphinganine reductase KLLA0F01771g 0 165000 165266 ON 6 F01771 complement(165000..165266) highly similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A Hypothetical ORF KLLA0F01793g 1 165790 166530 ON 6 F01793 (165790..166530) similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit KLLA0F01815g 1 166880 167947 ON 6 F01815 (166880..167947) similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Hypothetical ORF KLLA0F01837g 0 168045 170255 ON 6 F01837 complement(168045..170255) similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine threonine and tyrosine residues has a role in the DNA synthesis phase of the cell cycle KLLA0F01859g 1 170883 171383 ON 6 F01859 (170883..171383) some similarities with uniprot|P27344 Saccharomyces cerevisiae YBR278W DPB3 Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing mRNA abundance peaks at the G1/S boundary of the cell cycle KLLA0F01881g 1 171694 172395 ON 6 F01881 (171694..172395) similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function contains no hydrophobic stretches KLLA0F01903g 1 172931 174667 ON 6 F01903 (172931..174667) similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS expression is induced under low-nitrogen conditions KLLA0F01925g 1 175031 176317 ON 6 F01925 (175031..176317) similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 RNA polymerase II-associated protein defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes KLLA0F01947g 1 176686 177573 ON 6 F01947 (176686..177573) highly similar to gnl|GLV|CAGL0J05324g Candida glabrata CAGL0J05324g and similar to YJL068C uniprot|P40363 Saccharomyces cerevisiae YJL068C Hypothetical ORF KLLA0F01969g 0 177739 179541 ON 6 F01969 complement(177739..179541) similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C Hypothetical ORF KLLA0F01991g 0 179904 182510 ON 6 F01991 complement(179904..182510) similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C Hypothetical ORF KLLA0F02013g 1 183770 185470 ON 6 F02013 (183770..185470) similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA based on computational analysis of large-scale protein-protein interaction data KLLA0F02035g 1 185846 186283 ON 6 F02035 (185846..186283) similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit KLLA0F02057g 0 186620 188266 ON 6 F02057 complement(186620..188064,188257..188266) highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex Sec61p homolog involved in co-translational pathway of protein translocation not essential KLLA0F02079g 1 188816 189100 ON 6 F02079 (188816..189100) conserved hypothetical protein KLLA0F02101g 1 189413 190096 ON 6 F02101 (189413..190096) similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0F02123g 1 191154 193190 ON 6 F02123 (191154..193190) similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p possibly involved in control of actin cytoskeleton organization KLLA0F02145g 0 193239 195395 ON 6 F02145 complement(193239..195395) some similarities with uniprot|P47050 Saccharomyces cerevisiae YJL047C RTT101 Cullin family member subunit of a complex containing ubiquitin ligase activity binds HRT1 and is modified by the ubiquitin like protein RUB1 Regulator of Ty1 Transposition Regulator of Ty1 Transposition KLLA0F02167g 0 195562 197445 ON 6 F02167 complement(195562..197445) no similarity KLLA0F02189g 1 197699 198085 ON 6 F02189 (197699..198085) some similarities with uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres KLLA0F02211g 0 198132 198956 ON 6 F02211 complement(198132..198956) similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends binds to the RPR1 RNA subunit in Rnase P KLLA0F02233g 1 199224 200429 ON 6 F02233 (199224..200429) similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W Hypothetical ORF KLLA0F02255g 0 200492 202426 ON 6 F02255 complement(200492..202426) similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes KLLA0F02277g 1 203211 204107 ON 6 F02277 (203211..204107) no similarity KLLA0F02299g 1 205549 208167 ON 6 F02299 (205549..208167) conserved hypothetical protein KLLA0F02321g 1 208858 209721 ON 6 F02321 (208858..209721) similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43 KLLA0F02343g 1 209983 210849 ON 6 F02343 (209983..210849) similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules critical to kinetochore assembly KLLA0F02365g 0 211473 212747 ON 6 F02365 complement(211473..212747) similar to uniprot|Q06855 Saccharomyces cerevisiae YOR338W Hypothetical ORF KLLA0F02387g 0 213669 215852 ON 6 F02387 complement(213669..215852) similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer- mediated Activation Ty1 enhancer activator and to YLR098C uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc- finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; DNA-binding transcriptional activator or CHA1 KLLA0F02409g 0 216348 220091 ON 6 F02409 complement(216348..220091) weakly similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1 6 glucan biosynthesis mutations result in aberrant morphology and severe growth defects KLLA0F02431g 1 220848 223718 ON 6 F02431 (220848..223718) highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic alanyl-tRNA synthetase required for protein synthesis point mutation (cdc64-1 allele) causes cell cycle arrest at G1 lethality of null mutation is functionally complemented by human homolog KLLA0F02453g 1 224029 224673 ON 6 F02453 (224029..224673) similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP which cleaves pre- rRNA and nuclear RNase P which cleaves tRNA precursors to generate mature 5' ends KLLA0F02475g 0 224749 226041 ON 6 F02475 complement(224749..226041) similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Ortholog of human transcriptional coactivator SKIP can activate transcription of a reporter gene interacts with splicing factors Prp22p and Prp46p KLLA0F02497g 0 226225 228498 ON 6 F02497 complement(226225..228498) some similarities with uniprot|P39732 Saccharomyces cerevisiae YAL031C FUN21 Cytoplasmic protein of unknown function potential Cdc28p substrate KLLA0F02519g 0 228859 230187 ON 6 F02519 complement(228859..230187) similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2 ) channel required for maintenance of intramitochondrial Mg(2 ) concentrations at the correct level to support splicing of group II introns KLLA0F02541g 0 230613 231302 ON 6 F02541 complement(230613..231302) similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 vacuolar ATPase V1 domain subunit E (27 kDa) Klac_YGOB_Anc_7.64 1 231920 235492 ON 6 Anc_7.64 (231920..235492) ANNOTATED BY YGOB - KLLA0F02596g 1 235864 237840 ON 6 F02596 (235864..237840) some similarities with uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Multicopy suppressor of clathrin deficiency and of ts ipl1 mutants KLLA0F02610g 0 238258 238551 ON 6 F02610 complement(238258..238551) no similarity KLLA0F02640g 1 240871 241524 ON 6 F02640 (240871..241524) weakly similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Hypothetical ORF KLLA0F02662g 1 241804 242565 ON 6 F02662 (241804..242565) conserved hypothetical protein KLLA0F02684g 1 242962 245301 ON 6 F02684 (242962..245301) some similarities with uniprot|Q99248 Saccharomyces cerevisiae YOR019W Hypothetical ORF KLLA0F02706g 1 245783 248653 ON 6 F02706 (245783..248653) uniprot|Q96W95 Kluyveromyces lactis MSH2 Mismatch repair protein Msh2p KLLA0F02728g 1 249240 250232 ON 6 F02728 (249240..250232) similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 Large subunit of NADP dependent arabinose dehydrogenase involved in carbohydrate metabolism small subunit is unidentified KLLA0F02750g 0 250368 253814 ON 6 F02750 complement(250368..253814) some similarities with uniprot|Q12180 Saccharomyces cerevisiae YOL089C HAL9 Putative transcription factor containing a zinc finger overexpression increases salt tolerance through increased expression of the ENA1 (Na /Li extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression KLLA0F02772g 1 255901 256842 ON 6 F02772 (255901..256842) similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide localizes to both cytoplasm and nucleus KLLA0F02794g 0 257091 257873 ON 6 F02794 complement(257091..257873) similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Protein disulfide isomerase KLLA0F02816g 0 258214 261069 ON 6 F02816 complement(258214..261069) some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein predicted to have 5 transmembrane segments KLLA0F02838g 1 264329 266596 ON 6 F02838 (264329..266596) similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis associates with Ime1p and mediates its stability activates Ndt80p IME2 expression is positively regulated by Ime1p KLLA0F02860g 1 267100 268401 ON 6 F02860 (267100..268401) conserved hypothetical protein KLLA0F02882g 1 269162 271552 ON 6 F02882 (269162..271552) similar to uniprot|P36124 Saccharomyces cerevisiae YKR029C SET3 KLLA0F02904g 0 271837 272994 ON 6 F02904 complement(271837..272994) similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Peripheral GTPase of the mitochondrial inner membrane KLLA0F02926g 1 273193 274212 ON 6 F02926 (273193..274212) similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein associated with the RNA polymerase II Elongator complex involved in sensitivity to G1 arrest induced by Kluyveromyces lactis toxin zymocin KLLA0F02948g 0 274341 276029 ON 6 F02948 complement(274341..276029) weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C Hypothetical ORF KLLA0F02970g 0 276288 277772 ON 6 F02970 complement(276288..277772) uniprot|P26375 Kluyveromyces lactis KLLA0F02970g BAF1 Transcription factor BAF1 KLLA0F02992g 1 278441 279586 ON 6 F02992 (278441..279586) similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease 5' flap endonuclease required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family KLLA0F03014g 0 280155 282614 ON 6 F03014 complement(280155..282614) similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 Subunit of the eukaryotic translation initiation factor 3 (eIF3) involved in the assembly of preinitiation complex and start codon selection KLLA0F03036g 0 283504 284439 ON 6 F03036 complement(283504..284439) highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1 3-glucanase major protein of the cell wall involved in cell wall maintenance KLLA0F03058g 0 284859 286088 ON 6 F03058 complement(284859..286088) similar to uniprot|Q04867 Saccharomyces cerevisiae YMR310C Hypothetical ORF KLLA0F03080g 0 286585 287169 ON 6 F03080 complement(286585..287169) similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p) involved in glycogen metabolism and chromosome segregation proposed to regulate Glc7p activity via conformational alteration ortholog of the mammalian protein phosphatase inhibitor 2 KLLA0F03102g 0 287943 288860 ON 6 F03102 complement(287943..288860) similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles involved in vesicle formation and incorporation of specific secretory cargo KLLA0F03124g 0 289514 290815 ON 6 F03124 complement(289514..290815) highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Cytosolic ribosome-associated chaperone contains a DnaJ domain together with Ssz1p acts as a chaperone for nascent polypeptide chains KLLA0F03146g 0 291215 292882 ON 6 F03146 complement(291215..292882) conserved hypothetical protein KLLA0F03168g 1 294261 295817 ON 6 F03168 (294261..295817) similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 or uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5 KLLA0F03179g 0 296121 296402 ON 6 F03179 complement(296121..296402) conserved hypothetical protein KLLA0F03190g 0 296883 300236 ON 6 F03190 complement(296883..300236) similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor KLLA0F03212g 1 302915 303832 ON 6 F03212 (302915..303832) similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization KLLA0F03234g 0 304531 305034 ON 6 F03234 complement(304531..305034) no similarity KLLA0F03256g 1 306731 307588 ON 6 F03256 (306731..307588) highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Klac_YGOB_Anc_2.241 1 309169 310979 ON 6 Anc_2.241 (309169..310257,310260..310979) ANNOTATED BY YGOB - KLLA0F03311g 1 311639 313267 ON 6 F03311 (311639..313267) similar to uniprot|P53943 Saccharomyces cerevisiae YNL065W AQR1 Plasma membrane transporter of the major facilitator superfamily that confers resistance to short- chain monocarboxylic acids and quinidine KLLA0F03333g 0 313991 315220 ON 6 F03333 complement(313991..315220) highly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 yeast dnaJ homolog (nuclear envelope protein) heat shock protein KLLA0F03355g 1 316145 317032 ON 6 F03355 (316145..317032) similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1 KLLA0F03377g 0 317185 318615 ON 6 F03377 complement(317185..318615) similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p required for the modification of the adenine at position 58 in tRNAs especially tRNAi-Met first identified as a negative regulator of GCN4 expression KLLA0F03399g 1 319007 320866 ON 6 F03399 (319007..320866) similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis localized to the nucleolus KLLA0F03421g 0 321000 323243 ON 6 F03421 complement(321000..323243) similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes KLLA0F03443g 1 324020 324691 ON 6 F03443 (324020..324691) highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p KLLA0F03465g 0 325270 326349 ON 6 F03465 complement(325270..326349) conserved hypothetical protein KLLA0F03487g 1 326689 327231 ON 6 F03487 (326689..327231) similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0F03509g 1 327598 328761 ON 6 F03509 (327598..328761) similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase catalyzes the seventh step in histidine biosynthesis responsive to general control of amino acid biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts KLLA0F03531g 0 328830 333227 ON 6 F03531 complement(328830..333227) some similarities with uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side forms a subcomplex with Nup82p and Nsp1p KLLA0F03553g 0 333841 334689 ON 6 F03553 complement(333841..334689) similar to uniprot|P04840 Saccharomyces cerevisiae YNL055C POR1 Mitochondrial porin (voltage-dependent anion channel) outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability KLLA0F03575g 1 337386 340505 ON 6 F03575 (337386..340505) weakly similar to uniprot|P53950 Saccharomyces cerevisiae YNL054W VAC7 Integral vacuolar membrane protein may function to regulate Fab1p kinase activity KLLA0F03597g 1 341326 342408 ON 6 F03597 (341326..342408) similar to uniprot|P38590 Saccharomyces cerevisiae YNL053W MSG5 Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway regulates and is regulated by Slt2p also required for adaptive response to pheromone KLLA0F03619g 1 342770 345652 ON 6 F03619 (342770..345652) similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity potential Cdc28p substrate KLLA0F03641g 1 346255 347211 ON 6 F03641 (346255..346255,346760..347211) similar to uniprot|P00425 Saccharomyces cerevisiae YIL111w COX5B or uniprot|P00424 Saccharomyces cerevisiae YNL052w COX5A, subunit Va or Vb of cytochrome c oxidase KLLA0F03663g 1 348137 349243 ON 6 F03663 (348137..349243) similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family KLLA0F03685g 1 349421 350593 ON 6 F03685 (349421..350593) similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments KLLA0F03707g 0 350639 351460 ON 6 F03707 complement(350639..351460) weakly similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C Hypothetical ORF KLLA0F03729g 0 351716 354490 ON 6 F03729 complement(351716..354490) similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C SEC24 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport vesicle coat component KLLA0F03751g 1 355439 357490 ON 6 F03751 (355439..357490) similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Hypothetical ORF KLLA0F03773g 0 357597 359915 ON 6 F03773 complement(357597..359915) similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate has negligible fructose-2 6-bisphosphatase activity transcriptional regulation involves protein kinase A KLLA0F03795g 1 360687 361737 ON 6 F03795 (360687..360706,360840..361737) similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Mps One Binder;(putative) transcriptional regulator involved in mitosis KLLA0F03817g 1 362093 363805 ON 6 F03817 (362093..363805) similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1 2-mannosyltransferase catalyzes addition of the terminal alpha 1 2-Man to the Man5GlcNAc2- PP-dolichol intermediate during asparagine-linked glycosylation in the ER KLLA0F03839g 0 363977 365923 ON 6 F03839 complement(363977..365923) similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C SLM1 Phosphoinositide PI4 5P(2) binding protein forms a complex with Slm2p acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress phosphorylated by the Tor2p-containing complex TORC2 KLLA0F03861g 1 367117 367527 ON 6 F03861 (367117..367527) no similarity KLLA0F03883g 1 368275 370263 ON 6 F03883 (368275..370263) similar to uniprot|Q10740 Saccharomyces cerevisiae YNL045W Similar to human LTA4 hydrolase but in vivo substrates not yet defined. KLLA0F03905g 1 370581 371282 ON 6 F03905 (370581..370604,370776..371282) similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Interacts with YPT proteins KLLA0F03927g 1 371730 372767 ON 6 F03927 (371730..372767) weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function potential Cdc28p substrate overproduction suppresses a pam1 slv3 double null mutation KLLA0F03949g 0 372819 374246 ON 6 F03949 complement(372819..374246) similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Essential nuclear protein required for accumulation of box H/ACA snoRNAs and for rRNA processing interacts with Naf1p KLLA0F03971g 1 374590 375858 ON 6 F03971 (374590..375858) highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required along with Dph2p Kti11p Jjj3p and Dph5p for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph2p and Kti11p KLLA0F03993g 0 375915 378254 ON 6 F03993 complement(375915..378254) similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p) a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments KLLA0F04015g 0 378710 380215 ON 6 F04015 complement(378710..380215) weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes CYS3 and SMF2 expression is induced by stress or starvation during mitosis and late in meiosis member of the Swi4p/Mbp1p family potential Cdc28p substrate KLLA0F04037g 0 383428 384081 ON 6 F04037 complement(383428..384081) similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions involved in non-classical protein export pathway KLLA0F04059g 1 385832 387541 ON 6 F04059 (385832..387541) similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation induced during starvation of a/a diploids late in sporulation but dispensable for sporulation KLLA0F04081g 0 387824 388303 ON 6 F04081 complement(387824..388303) similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase KLLA0F04103g 1 389159 390244 ON 6 F04103 (389159..390244) uniprot|O94229 Kluyveromyces lactis KLLA0F04103g IDH1 Isocitrate dehydrogenase subunit 1 KLLA0F04125g 1 392229 393728 ON 6 F04125 (392229..393728) conserved hypothetical protein Klac_6.trna1D 0 393907 393978 ON 6 tD-GUC complement(393907..393978) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 KLLA0F04169g 1 395518 397269 ON 6 F04169 (395518..397269) similar to uniprot|P38361 uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter active in early growth phase KLLA0F04191g 1 397611 400268 ON 6 F04191 (397611..400268) similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor component of the U4/U6-U5 snRNP complex KLLA0F04213g 1 400673 402979 ON 6 F04213 (400673..402979) similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway requires 2-aminoadipate semialdehyde as co-inducer KLLA0F04235g 0 403194 404537 ON 6 F04235 complement(403194..404537) conserved hypothetical protein KLLA0F04257g 0 404952 406457 ON 6 F04257 complement(404952..406457) conserved hypothetical protein KLLA0F04279g 1 407511 408962 ON 6 F04279 (407511..408962) some similarities with uniprot|Q05497 Saccharomyces cerevisiae YDR338C Hypothetical ORF KLLA0F04301g 1 409431 410447 ON 6 F04301 (409431..410447) similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Hypothetical ORF KLLA0F04323g 1 411143 411739 ON 6 F04323 (411143..411739) highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C PST2 Protein of unknown function with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; GFP-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0F04345g 1 413160 415718 ON 6 F04345 (413160..415718) weakly similar to uniprot|Q00816 Saccharomyces cerevisiae YDR028C REG1 Regulatory subunit of type 1 protein phosphatase Glc7p involved in negative regulation of glucose-repressible genes involved in RNA processing KLLA0F04367g 1 416114 418654 ON 6 F04367 (416114..418654) similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex KLLA0F04389g 1 419265 421052 ON 6 F04389 (419265..421052) uniprot|Q05950 Kluyveromyces lactis KLLA0F04389g REB1 DNA-binding protein REB1 KLLA0F04411g 0 421860 422927 ON 6 F04411 complement(421860..422927) no similarity KLLA0F04433g 0 424427 425668 ON 6 F04433 complement(424427..425668) some similarities with uniprot|P40472 Saccharomyces cerevisiae YIL123W SIM1 (putative) involved in control of DNA replication KLLA0F04455g 0 428010 428927 ON 6 F04455 complement(428010..428927) similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles and ER involved in phosphatidic acid biosynthesis and required for spore germination capable of metabolizing mammalian steroid hormones KLLA0F04477g 0 429732 432785 ON 6 F04477 complement(429732..432785) highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex which catalyzes a key step in the tricarboxylic acid (TCA) cycle the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA KLLA0F04499g 0 434569 435144 ON 6 F04499 complement(434569..435144) highly similar to uniprot|P05738 Saccharomyces cerevisiae uniprot|P05738 Saccharomyces cerevisiae YGL147C RPL9A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins and to YNL067W uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins KLLA0F04521g 0 435649 439683 ON 6 F04521 complement(435649..439683) similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 helicase related protein snf2 homolog KLLA0F04543g 1 440338 440943 ON 6 F04543 (440338..440943) similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C Hypothetical ORF KLLA0F04565g 0 441106 444195 ON 6 F04565 complement(441106..444195) similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription possible role in assembly of a multiprotein complex(es) required for NER and RNAP II transcription KLLA0F04587g 1 444673 451449 ON 6 F04587 (444673..451449) similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Identified in a hunt for mutants that activate OCH1 transcription Transcriptional Activator of OCH1 KLLA0F04609g 0 451579 454329 ON 6 F04609 complement(451579..454329) similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Proposed transcriptional activator member of the Gal4p family of zinc cluster proteins KLLA0F04631g 1 455651 457990 ON 6 F04631 (455651..457990) similar to uniprot|P40466 Saccharomyces cerevisiae YIL131C FKH1 Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth also involved in chromatin silencing at HML and HMR KLLA0F04653g 1 458393 459034 ON 6 F04653 (458393..459034) weakly similar to uniprot|Q45U15 Saccharomyces cerevisiae YIL132C CSM2 KLLA0F04675g 1 459700 460844 ON 6 F04675 (459700..459733,460279..460844) highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p and to YNL069C uniprot|P26785 Saccharomyces cerevisiae YNL069C RPL16B N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5. 8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p KLLA0F04697g 0 461126 462049 ON 6 F04697 complement(461126..462049) similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD) from mitochondria where it is synthesized from riboflavin to the cytosol Klac_YGOB_Anc_2.226 0 462343 462525 ON 6 Anc_2.226 complement(462343..462525) ANNOTATED BY YGOB - KLLA0F04741g 0 463107 464528 ON 6 F04741 complement(463107..464528) similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA KLLA0F04774g 0 465362 466276 ON 6 F04774 complement(465362..466276) similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit removes RNA primers during Okazaki fragment synthesis cooperates with Rad27p nuclease KLLA0F04796g 0 466476 468029 ON 6 F04796 complement(466476..468029) similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria KLLA0F04818g 1 469283 470764 ON 6 F04818 (469283..470764) similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase which is required for DNA synthesis and double-strand break repair KLLA0F04840g 1 474544 476454 ON 6 F04840 (474544..476454) some similarities with uniprot|P53438 Saccharomyces cerevisiae YMR016C SOK2 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase displays homologies to several transcription factors KLLA0F04862g 1 476880 477830 ON 6 F04862 (476880..477830) weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W Spindle pole body component SPC42 KLLA0F04884g 0 478044 481682 ON 6 F04884 complement(478044..481682) highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex which surrounds transport vesicles in the early secretory pathway KLLA0F04906g 0 482183 483673 ON 6 F04906 complement(482183..483673) similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C KLLA0F04928g 0 484158 485249 ON 6 F04928 complement(484158..485249) similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Hypothetical ORF KLLA0F04950g 1 486258 488345 ON 6 F04950 (486258..488345) similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase reduces siderophore-bound iron and oxidized copper prior to uptake by transporters expression induced by low copper and iron levels KLLA0F04972g 0 488863 489963 ON 6 F04972 complement(488863..489963) similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123 KLLA0F05005g 1 490536 492128 ON 6 F05005 (490536..492128) highly similar to uniprot|P39078 Saccharomyces cerevisiaeYDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p KLLA0F05027g 0 492389 493285 ON 6 F05027 complement(492389..493285) similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase produces cardiolipin which is an important constituent of mitochondrial membranes required for normal mitochondrial membrane potential and function KLLA0F05049g 1 494045 496126 ON 6 F05049 (494045..496126) similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase KLLA0F05071g 0 496371 501533 ON 6 F05071 complement(496371..501533) highly similar to uniprot|P04050 Saccharomyces cerevisiae YDL140C KLLA0F05093g 0 502635 503753 ON 6 F05093 complement(502635..503753) similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin) catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity KLLA0F05115g 0 504092 504694 ON 6 F05115 complement(504092..504694) similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Suppressor of chromosome missegregation KLLA0F05137g 0 504967 505221 ON 6 F05137 complement(504967..505221) similar to uniprot|Q05809 Saccharomyces cerevisiae YLR218C Hypothetical ORF KLLA0F05159g 1 506007 509702 ON 6 F05159 (506007..509702) similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 involved in protein transport from endoplasmic reticulum to Golgi Component (p150) of COPII coat of secretory pathway vesicles KLLA0F05181g 1 510384 512747 ON 6 F05181 (510384..512747) uniprot|O13477 Kluyveromyces lactis RAG4 Putative glucose sensor KLLA0F05203g 1 513318 514319 ON 6 F05203 (513318..514319) similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1 KLLA0F05225g 1 515391 515936 ON 6 F05225 (515391..515936) highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W ARF1 ADP-ribosylation factor GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi functionally interchangeable with Arf2p KLLA0F05247g 1 517241 518135 ON 6 F05247 (517241..517243,517776..518135) highly similar to uniprot|P39741 Saccharomyces cerevisiae YDL191W RPL35A and YDL136W RPL35B, proteins component of the large (60S) ribosomal subunit KLLA0F05269g 0 518381 521254 ON 6 F05269 complement(518381..521254) similar to uniprot|P54860 Saccharomyces cerevisiae YDL190C UFD2 Ubiquitin chain assembly factor (E4) KLLA0F05291g 1 522324 523601 ON 6 F05291 (522324..523601) weakly similar to uniprot|Q870H2 Saccharomyces cerevisiae YDL189W RBS1 Protein of unknown function identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain KLLA0F05313g 0 523845 524444 ON 6 F05313 complement(523845..524444) highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor KLLA0F05335g 1 524979 525563 ON 6 F05335 (524979..525563) conserved hypothetical protein KLLA0F05357g 0 525923 527005 ON 6 F05357 complement(525923..527005) highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C PPH21 Catalytic subunit of protein phosphatase 2A functionally redundant with Pph22p methylated at C terminus forms alternate complexes with several regulatory subunits involved in signal transduction and regulation of mitosis KLLA0F05379g 1 527893 528615 ON 6 F05379 (527893..528615) some similarities with uniprot|P48568 Saccharomyces cerevisiae YDL186W Hypothetical ORF KLLA0F05401g 1 529272 532355 ON 6 F05401 (529272..532355) highly similar to uniprot|P17255 Saccharomyces cerevisiae YDL185W TFP1 Vacuolar ATPase V1 domain subunit A protein precursor is spliced to yield the extein Tfp1p and the intein Vde (PI-SceI) which is a site-specific endonuclease Klac_YGOB_Anc_7.299 0 533118 533195 ON 6 Anc_7.299 complement(533118..533195) ANNOTATED BY YGOB - KLLA0F05423g 0 533977 534867 ON 6 F05423 complement(533977..534867) similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Hypothetical ORF KLLA0F05445g 1 535675 537105 ON 6 F05445 (535675..537105) weakly similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W KLLA0F05467g 1 537921 540359 ON 6 F05467 (537921..540359) similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin structural protein of SCF complexes (which also contain Skp1p Cdc34p and an F-box protein) involved in ubiquitination SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation KLLA0F05489g 1 541146 542471 ON 6 F05489 (541146..542471) highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W LYS21 and to uniprot|P48570 Saccharomyces cerevisiae YDL182W LYS20 homocitrate synthase KLLA0F05511g 1 543219 543488 ON 6 F05511 (543219..543488) weakly similar to uniprot|P01097 Saccharomyces cerevisiae YDL181W INH1 Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures Klac_6.trna2E 1 544290 544361 ON 6 tE-CUC (544290..544361) tRNA Type: Glu (E) | Anti-Codon: CUC | Cove Score: 69.05 KLLA0F05555g 1 544997 545311 ON 6 F05555 (544997..545311) highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component KLLA0F05588g 1 546398 547198 ON 6 F05588 (546398..547198) weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Hypothetical ORF KLLA0F05610g 1 548033 549529 ON 6 F05610 (548033..549529) similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Hypothetical ORF KLLA0F05632g 1 550145 551365 ON 6 F05632 (550145..551365) similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W KLLA0F05654g 1 552056 552991 ON 6 F05654 (552056..552991) weakly similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W PCL2 G1 cyclin associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle essential for cell morphogenesis localizes to sites of polarized cell growth KLLA0F05676g 0 553406 555898 ON 6 F05676 complement(553406..555898) highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase in ER nuclear membrane and cytosol with homology to mammalian p97 in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome KLLA0F05731g 0 556540 557134 ON 6 F05731 complement(556540..556934,557083..557134) highly similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C KLLA0F05753g 1 558009 559640 ON 6 F05753 (558009..559640) highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase located in the mitochondrial matrix KLLA0F05775g 1 560270 561199 ON 6 F05775 (560270..561199) highly similar to uniprot|Q07551 Saccharomyces cerevisiae YDL124W NADPH-dependent alpha-keto amide reductase reduces aromatic alpha-keto amides aliphatic alpha-keto esters and aromatic alpha-keto esters KLLA0F05797g 0 561393 561914 ON 6 F05797 complement(561393..561914) similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Hypothetical ORF KLLA0F05819g 1 562259 564289 ON 6 F05819 (562259..564289) similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Hypothetical ORF KLLA0F05841g 0 564453 564866 ON 6 F05841 complement(564453..564866) similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function localized to the vacuolar outer membrane Klac_6.trna3I 1 565690 565763 ON 6 tI-AAU (565690..565763) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 KLLA0F05896g 0 566005 567054 ON 6 F05896 complement(566005..567054) similar to uniprot|P40507 Saccharomyces cerevisiae and similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C AIR2 RING finger proteins KLLA0F05918g 1 567803 570037 ON 6 F05918 (567803..570037) highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase cytoplasmic KLLA0F05940g 0 570437 571330 ON 6 F05940 complement(570437..571330) weakly similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Hypothetical ORF KLLA0F05962g 1 571896 572699 ON 6 F05962 (571896..572699) highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Protein involved in bud-site selection diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0F05984g 1 573009 573524 ON 6 F05984 (573009..573524) similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the small subunit required for respiration and for maintenance of the mitochondrial genome KLLA0F06006g 0 574421 575086 ON 6 F06006 complement(574421..575086) similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W Hypothetical ORF KLLA0F06028g 1 576687 578213 ON 6 F06028 (576687..578213) some similarities with uniprot|P25036 Saccharomyces cerevisiae YOR003W YSP3 subtilisin-like protease III KLLA0F06050g 0 578912 579571 ON 6 F06050 complement(578912..579571) similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W MAS6 Essential protein of the mitochondrial inner membrane component of the mitochondrial import system KLLA0F06061g 1 580713 580970 ON 6 F06061 (580713..580970) no similarity KLLA0F06072g 1 583276 589971 ON 6 F06072 (583276..589971) highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C ACC1 Acetyl-CoA carboxylase biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA required for de novo biosynthesis of long-chain fatty acids KLLA0F06094g 0 590298 591377 ON 6 F06094 complement(590298..591377) similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 tRNA dihydrouridine synthase KLLA0F06116g 1 592103 595960 ON 6 F06116 (592103..595960) conserved hypothetical protein KLLA0F06138g 0 596318 597241 ON 6 F06138 complement(596318..597241) some similarities with uniprot|Q03695 Saccharomyces cerevisiae YMR206W Hypothetical ORF KLLA0F06160g 1 598549 601128 ON 6 F06160 (598549..601128) similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter deletion of pho84 pho87 pho89 pho90 and pho91 causes synthetic lethality transcription independent of Pi and Pho4p activity overexpression results in vigorous growth KLLA0F06182g 0 601351 602730 ON 6 F06182 complement(601351..602730) similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 converts ATP and uridine to ADP and UMP Uridine kinase KLLA0F06204g 1 602989 605622 ON 6 F06204 (602989..605622) similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family required for activation of the spliceosome before the first transesterification step in RNA splicing KLLA0F06226g 1 606977 607993 ON 6 F06226 (606977..607993) similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S- D-lactoylglutathione expression regulated by methylglyoxal levels and osmotic stress KLLA0F06248g 1 608680 611496 ON 6 F06248 (608680..611496) uniprot|Q03216 Kluyveromyces lactis KLLA0F06248g PFK2 6- phosphofructokinase subunit beta KLLA0F06270g 1 611896 612927 ON 6 F06270 (611896..612927) some similarities with uniprot|Q03694 Saccharomyces cerevisiae YMR204C Hypothetical ORF KLLA0F06292g 0 613470 614633 ON 6 F06292 complement(613470..614633) highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Essential component of the preprotein translocase of the mitochondrial outer membrane (TOM complex) in which it constitutes the core element of the protein conducting pore KLLA0F06314g 0 615122 615493 ON 6 F06314 complement(615122..615493) similar to uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Component of the Med9/10 module which is a subcomplex within the RNA polymerase II Mediator complex required for regulation of RNA polymerase II activity KLLA0F06336g 0 615776 616447 ON 6 F06336 complement(615776..616447) highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis KLLA0F06358g 0 616922 617587 ON 6 F06358 complement(616922..617587) weakly similar to YNR009w KLLA0F06380g 0 618296 620266 ON 6 F06380 complement(618296..620266) similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification one of several acyltransferases that contribute to triglyceride synthesis putative homolog of human lecithin cholesterol acyltransferase KLLA0F06402g 1 621021 621929 ON 6 F06402 (621021..621929) similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 Protein involved in autophagy E2-like enzyme that plays a role in formation of Atg8p- phosphatidylethanolamine conjugates which are involved in membrane dynamics during autophagy KLLA0F06424g 1 622190 623333 ON 6 F06424 (622190..622225,622299..623333) similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair subunit of Nucleotide Excision Repair Factor 1 (NEF1) contains zinc finger motif homolog of human XPA protein KLLA0F06446g 0 623443 625254 ON 6 F06446 complement(623443..625254) similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 hydrophilic protein has cysteine rich putative zinc finger esential for function KLLA0F06468g 0 625692 626417 ON 6 F06468 complement(625692..626417) similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Protein that may be involved in cell wall function mutations in rot1 cause cell wall defects suppress tor2 mutations and are synthetically lethal with rot2 mutations KLLA0F06490g 0 626983 628569 ON 6 F06490 complement(626983..628569) similar to uniprot|P20437 Saccharomyces cerevisiae YMR199W CLN1 role in cell cycle START G(sub)1 cyclin KLLA0F06512g 0 629870 630685 ON 6 F06512 complement(629870..630685) conserved hypothetical protein KLLA0F06534g 1 631051 632247 ON 6 F06534 (631051..632247) weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication localized at the central plaque periphery forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p required for mitotic functions of Cdc5p KLLA0F06556g 1 633167 634261 ON 6 F06556 (633167..634261) highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7- phosphate (DAHP) synthase KLLA0F06578g 1 634720 636378 ON 6 F06578 (634720..636378) highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase) catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR) a purine precursor KLLA0F06600g 0 636501 637943 ON 6 F06600 complement(636501..637943) similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p localizes to the nucleus required for nucleocytoplasmic trafficking of macromolecules potentially phosphorylated by Cdc28p KLLA0F06622g 1 638611 640047 ON 6 F06622 (638611..640047) similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs required for pre-rRNA processing and 40S ribosomal subunit synthesis localized in the nucleus and concentrated in the nucleolus KLLA0F06644g 0 640261 641043 ON 6 F06644 complement(640261..641043) similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Use1p is a SNARE and forms a complex with the SNAREs Sec22p Sec20p and Ufe1p. The protein is localized to the ER and use1 mutants show defects in retrograde traffic from the Golgi to the ER Protein required for cell viability KLLA0F06666g 0 641931 643877 ON 6 F06666 complement(641931..643877) highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis localized to the cytoplasm KLLA0F06688g 1 644040 645299 ON 6 F06688 (644040..645299) similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W Hypothetical ORF KLLA0F06710g 1 645650 648940 ON 6 F06710 (645650..648940) similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation and a complex with Ioc3p to repress transcription initiation KLLA0F06732g 0 649269 649754 ON 6 F06732 complement(649269..649754) highly similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor KLLA0F06754g 0 650475 651509 ON 6 F06754 complement(650475..651509) similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein homologous to Sec13p KLLA0F06776g 1 651801 653144 ON 6 F06776 (651801..653144) similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation inhibited by tunicamycin KLLA0F06798g 0 653398 654159 ON 6 F06798 complement(653398..654159) similar to uniprot|P38331 Saccharomyces cerevisiae YBR242W Hypothetical ORF or YGL101W uniprot|P53144 Saccharomyces cerevisiae YGL101W Hypothetical ORF KLLA0F06831g 0 654656 655849 ON 6 F06831 complement(654656..655056,655801..655849) uniprot|Q8J287 Kluyveromyces lactis RPL28 protein KLLA0F06853g 1 656373 657959 ON 6 F06853 (656373..657959) similar to uniprot|P38142 Saccharomyces cerevisiae YBR241C Hypothetical ORF KLLA0F06875g 0 658475 658900 ON 6 F06875 complement(658475..658900) conserved hypothetical protein KLLA0F06897g 1 659764 661596 ON 6 F06897 (659764..661596) similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function transcription is induced under conditions of zinc deficiency mutant phenotype suggests a role in uptake of zinc KLLA0F06919g 0 661670 665638 ON 6 F06919 complement(661670..665638) similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 RNA polymerase II mediator complex subunit KLLA0F06941g 0 665970 667862 ON 6 F06941 complement(665970..667862) similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis, putative ATP-dependent RNA helicase of the DEAD-box protein family KLLA0F06963g 1 668130 668405 ON 6 F06963 (668130..668405) highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C KLLA0F06985g 0 668701 670158 ON 6 F06985 complement(668701..670158) similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W Hypothetical ORF KLLA0F07007g 1 671210 671713 ON 6 F07007 (671210..671713) highly similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C KLLA0F07029g 1 672114 673094 ON 6 F07029 (672114..673094) similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches required for cortical localization of calmodulin KLLA0F07073g 1 675221 676897 ON 6 F07073 (675221..676897) some similarities with uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C STP4 Protein involved in pre-tRNA splicing and in uptake of branched-chain amino acids KLLA0F07095g 0 677773 679005 ON 6 F07095 complement(677773..679005) highly similar to uniprot|Q765N3 Saccharomyces kluyveri Sk Delta 12-fatty acid desaturase KLLA0F07117g 1 680589 681044 ON 6 F07117 (680589..681044) weakly similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle subunit KLLA0F07139g 0 681163 682401 ON 6 F07139 complement(681163..682401) similar to uniprot|Q12229 YDL091c Saccharomyces cerevisiae UBX3 UBX domain-containing protein that interacts with Cdc48p KLLA0F07161g 0 682786 684075 ON 6 F07161 complement(682786..684075) similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 essential for processing of ras proteins beta subunit of farnesyltransferase KLLA0F07183g 1 684265 686322 ON 6 F07183 (684265..686322) weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C KLLA0F07205g 1 686532 688172 ON 6 F07205 (686532..688172) weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W Protein of unknown function interacts with meiotic division protein Csm1p green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery potential Cdc28p substrate KLLA0F07227g 0 688282 689526 ON 6 F07227 complement(688282..689526) some similarities with uniprot|Q05166 Saccharomyces cerevisiae YDL088C ASM4 Nuclear pore complex subunit part of a subcomplex also containing Nup53p Nup170p and Pse1p KLLA0F07249g 0 689786 690556 ON 6 F07249 complement(689786..690556) similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex splicing factor involved in recognition of 5' splice site KLLA0F07271g 1 690795 691490 ON 6 F07271 (690795..691490) no similarity KLLA0F07293g 1 691582 692085 ON 6 F07293 (691582..692085) similar to uniprot|P28627 Saccharomyces cerevisiae YMR150c IMP1 protease, mitochondrial KLLA0F07315g 0 692238 693035 ON 6 F07315 complement(692238..693035) similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 oligosaccharyl transferase glycoprotein complex delta subunit KLLA0F07337g 0 693418 693804 ON 6 F07337 complement(693418..693804) no similarity KLLA0F07348g 0 694278 694541 ON 6 F07348 complement(694278..694541) no similarity KLLA0F07359g 0 695133 696101 ON 6 F07359 complement(695133..696101) some similarities with uniprot|Q03083 Saccharomyces cerevisiae YPL034W Hypothetical ORF KLLA0F07381g 1 696302 697114 ON 6 F07381 (696302..697114) similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W Hypothetical ORF KLLA0F07403g 1 697593 698636 ON 6 F07403 (697593..698636) similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 Subunit of the core complex of translation initiation factor 3(eIF3) which is essential for translation KLLA0F07425g 0 699177 699380 ON 6 F07425 complement(699177..699380) similar to uniprot|Q3E7B7 Saccharomyces cerevisiae YDL085C-A KLLA0F07447g 1 700685 703612 ON 6 F07447 (700685..703612) similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes; Cu(2+)- transporting ATPase KLLA0F07469g 1 703955 706933 ON 6 F07469 (703955..706933) similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease involved in RNA metabolism including rRNA and snRNA processing as well as mRNA transcription termination Klac_6.trna4E 1 707161 707232 ON 6 tE-UUC (707161..707232) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0F07513g 1 707516 710662 ON 6 F07513 (707516..710662) similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Protein whose overexpression affects chromosome stability potential Cdc28p substrate homolog of Snf2p KLLA0F07557g 0 711607 713070 ON 6 F07557 complement(711607..713070) similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase catalyzes the ATP- dependent synthesis of glutathione (GSH) from gamma- glutamylcysteine and glycine induced by oxidative stress and heat shock KLLA0F07579g 0 713403 716507 ON 6 F07579 complement(713403..716507) uniprot|P32257 Kluyveromyces lactis KLLA0F07579g GAL11 Transcription regulatory protein GAL11 KLLA0F07601g 0 717689 718606 ON 6 F07601 complement(717689..718606) similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C Hypothetical ORF KLLA0F07623g 1 720246 723935 ON 6 F07623 (720246..723935) similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status KLLA0F07645g 0 724204 725763 ON 6 F07645 complement(724204..725763) similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease KLLA0F07667g 1 726241 727314 ON 6 F07667 (726241..727314) some similarities with uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein KLLA0F07689g 1 727832 729664 ON 6 F07689 (727832..729664) highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 protein phosphatase 2A regulatory subunit A KLLA0F07711g 0 729829 731004 ON 6 F07711 complement(729829..731004) similar to uniprot|Q08214 Saccharomyces cerevisiae YOL043C NTG2 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase KLLA0F07733g 1 731317 732432 ON 6 F07733 (731317..732432) similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W KLLA0F07755g 1 732874 733497 ON 6 F07755 (732874..733497) conserved hypothetical protein KLLA0F07777g 0 733753 734535 ON 6 F07777 complement(733753..734535) similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8 KLLA0F07799g 0 734889 736277 ON 6 F07799 complement(734889..736277) similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C KLLA0F07821g 1 737054 738874 ON 6 F07821 (737054..738874) similar to uniprot|Q758U6 Ashbya gossypii AEL344W and some similarities with YAL013W uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in the regulation of structural genes involved in phospholipid biosynthesis also participates in regulation of metabolically unrelated genes as well as maintenance of mating efficiency and sporulation KLLA0F07843g 0 739661 740089 ON 6 F07843 complement(739661..740089) highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C KLLA0F07865g 1 741097 741417 ON 6 F07865 (741097..741417) highly similar to uniprot|P05319 Saccharomyces cerevisiae YOL039W RPP2A Ribosomal protein P2 alpha a component of the ribosomal stalk which is involved in the interaction between translational elongation factors and the ribosome regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm KLLA0F07887g 1 741965 742273 ON 6 F07887 (741965..742273) no similarity KLLA0F07909g 1 742468 743643 ON 6 F07909 (742468..743643) highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine KLLA0F07931g 1 744157 745629 ON 6 F07931 (744157..745629) similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 ER-localized protein required for protein translocation into the ER interacts with the ATPase domain of the Kar2p chaperone suggesting some role in modulating its activity homolog of Yarrowia lipolytica SLS1 GrpE-like protein in the ER KLLA0F07953g 0 745723 746451 ON 6 F07953 complement(745723..746451) similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W Hypothetical ORF KLLA0F07975g 0 746708 748336 ON 6 F07975 complement(746708..748336) similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase encoded by a nuclear gene KLLA0F07997g 0 748561 751920 ON 6 F07997 complement(748561..751920) similar to uniprot|Q08204 YOL034W Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein, interacts with Rhc18p and Nse1p to form a large complex KLLA0F08019g 1 752184 754460 ON 6 F08019 (752184..754460) some similarities with uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function component of the Swr1p complex that incorporates Htz1p into chromatin KLLA0F08041g 0 754518 755876 ON 6 F08041 complement(754518..755876) similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of the mitochondrial sorting and assembly machinery (SAM complex) has a role in assembly of the TOM complex which mediates protein import through the outer membrane required for normal mitochondrial morphology and inheritance KLLA0F08063g 1 756362 757231 ON 6 F08063 (756362..757231) similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Integral nuclear/ER membrane protein of unknown function required for normal nuclear envelope morphology and sporulation KLLA0F08085g 1 758631 760640 ON 6 F08085 (758631..760640) similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A) KLLA0F08107g 1 761242 761748 ON 6 F08107 (761242..761748) some similarities with uniprot|P18411 Saccharomyces cerevisiae YAL008W FUN14 Mitochondrial protein of unknown function KLLA0F08129g 1 761965 762597 ON 6 F08129 (761965..762597) highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor KLLA0F08162g 1 763454 764377 ON 6 F08162 (763454..764377) highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Long chain base-responsive inhibitor of protein kinases Phk1p and Phk2p acts along with Lsp1p to down-regulate heat stress resistance via regulation of the Pkc1p and Ypk1p pathways phosphorylated by Phk1p and Phk2p KLLA0F08184g 1 765209 767512 ON 6 F08184 (765209..767512) similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 component of oligomeric Golgi complex KLLA0F08206g 1 767745 770261 ON 6 F08206 (767745..770261) similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C KLLA0F08228g 0 770578 771435 ON 6 F08228 complement(770578..771435) highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 20S proteasome beta-type subunit KLLA0F08261g 1 772179 772703 ON 6 F08261 (772179..772703) highly similar to uniprot|P06380 Saccharomyces cerevisiae RPL11A and to uniprot|P06380 Saccharomyces cerevisiae YGR085C RPL11B component of the large (60S) ribosomal subunit KLLA0F08283g 0 772816 773331 ON 6 F08283 complement(772816..773331) conserved hypothetical protein KLLA0F08305g 1 773720 774685 ON 6 F08305 (773720..774685) similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit KLLA0F08327g 1 775125 776933 ON 6 F08327 (775125..776933) similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 activity subsequently regulated by phosphorylated eIF2 first identified as a negative regulator of GCN4 expression KLLA0F08349g 0 777144 777572 ON 6 F08349 complement(777144..777572) highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit KLLA0F08371g 1 779264 781009 ON 6 F08371 (779264..781009) no similarity KLLA0F08393g 0 781508 783019 ON 6 F08393 complement(781508..783019) uniprot|P09608 Kluyveromyces lactis KLLA0F08393g GAL1 Galactokinase KLLA0F08415g 1 783785 785851 ON 6 F08415 (783785..785851) uniprot|P09609 Kluyveromyces lactis KLLA0F08415g GAL10 GAL10 bifunctional protein KLLA0F08437g 1 786742 787854 ON 6 F08437 (786742..787854) uniprot|P09580 Kluyveromyces lactis KLLA0F08437g GAL7 Galactose-1-phosphate uridylyltransferase KLLA0F08459g 0 787966 790479 ON 6 F08459 complement(787966..790479) similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p Ard1p Nat5p) N-terminally acetylates many proteins which influences multiple processes such as the cell cycle heat-shock resistance mating sporulation and telomeric silencing KLLA0F08481g 0 790859 792310 ON 6 F08481 complement(790859..792310) similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome forms a complex with Hsh49p and Hsh155p KLLA0F08492g 0 792545 792775 ON 6 F08492 complement(792545..792775) conserved hypothetical protein KLLA0F08503g 1 792967 793668 ON 6 F08503 (792967..793668) similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W Hypothetical ORF KLLA0F08525g 0 793929 795410 ON 6 F08525 complement(793929..795410) similar to uniprot|Q08777 Saccharomyces cerevisiae YOR306C MCH5 Protein with similarity to mammalian monocarboxylate permeases which are involved in transport of monocarboxylic acids across the plasma membrane mutant is not deficient in monocarboxylate transport KLLA0F08547g 1 796328 797254 ON 6 F08547 (796328..797254) highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Yeast suppressor gene of HM mutant (abf2) DNA-binding protein mtDNA stabilizing protein mitochondrial inner membrane protein with low homology to RIM2 KLLA0F08569g 0 797808 799151 ON 6 F08569 complement(797808..799151) similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 multicopy suppressor of ypt1 deletion homolog of chloroplast phosphate transporter KLLA0F08591g 0 799590 801263 ON 6 F08591 complement(799590..801263) weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 66kD U4/U6.U5 snRNP associated protein KLLA0F08613g 0 801623 803158 ON 6 F08613 complement(801623..803158) similar to uniprot|Q12499 Saccharomyces cerevisiae YOR310C NOP58 Protein involved in pre-rRNA processing 18S rRNA synthesis and snoRNA synthesis component of the small subunit processome complex which is required for processing of pre-18S rRNA KLLA0F08635g 0 803832 804683 ON 6 F08635 complement(803832..804683) similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C HSD1 Endoplasmic reticulum (ER)-resident membrane protein overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation KLLA0F08657g 0 805298 805738 OFF 6 F08657 complement(805298..805738) highly similar to uniprot|P47913 Saccharomyces cerevisiae YOR312C RPL20B and highly similar to uniprot|P47913 Saccharomyces cerevisiae YMR242C RPL20A Protein component of the large (60S) ribosomal subunit Klac_YGOB_F08657 0 805298 806164 ON 6 F08657 complement(805298..805812,806164..806164) ANNOTATED BY YGOB - KLLA0F08679g 0 807369 808451 ON 6 F08679 complement(807369..808451) weakly similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation not required for sporulation heterologous expression in E. coli induces the SOS response that senses DNA damage KLLA0F08701g 1 811112 812152 ON 6 F08701 (811112..812152) weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W Protein of unknown function found in the cytoplasm and the nucleus potential Cdc28p substrate KLLA0F08723g 0 813012 814322 ON 6 F08723 complement(813012..814322) similar to uniprot|P20107 Saccharomyces cerevisiae YMR243C ZRC1 and to uniprot|P32798 Saccharomyces cerevisiae YOR316C COT1 KLLA0F08745g 1 815922 816983 ON 6 F08745 (815922..816983) similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Hypothetical ORF KLLA0F08767g 0 817541 817837 ON 6 F08767 complement(817541..817837) similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Hypothetical ORF KLLA0F08789g 1 818541 819731 ON 6 F08789 (818541..819731) some similarities with uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members Ypt1p is the preferred in vitro substrate but also acts on Sec4p Ypt31p and Ypt32p involved in the regulation of ER to Golgi vesicle transport KLLA0F08811g 0 819834 821744 ON 6 F08811 complement(819834..821744) similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA required for SAGA-mediated inhibition at some promoters KLLA0F08833g 1 822039 822860 ON 6 F08833 (822039..822860) similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of the evolutionarily-conserved CCR4- NOT transcriptional regulatory complex involved in controlling mRNA initiation elongation and degradation putative ABC ATPase interacts with Ssn2p Ssn3p and Ssn8p KLLA0F08855g 1 823595 824656 ON 6 F08855 (823595..824656) similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase catalyzes the introduction of a C-5(6) double bond into episterol a precursor in ergosterol biosynthesis mutants are viable but cannot grow on non-fermentable carbon sources KLLA0F08877g 1 825217 826182 ON 6 F08877 (825217..826182) uniprot|Q8J0L1 Kluyveromyces lactis cak1 Cyclin- dependent kinase activating kinase 1 Klac_YGOB_18260 0 826175 826375 ON 6 18260 complement(826175..826375) ANNOTATED BY YGOB - 8bp overlap with KLLA0F08877g but conserved across species KLLA0F08899g 1 826574 828685 ON 6 F08899 (826574..828685) weakly similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Hypothetical ORF KLLA0F08921g 0 829001 830410 ON 6 F08921 complement(829001..830410) highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 serine hydroxymethyltransferase KLLA0F08954g 0 831232 832335 ON 6 F08954 complement(831232..832335) similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W KLLA0F08976g 0 833390 834211 ON 6 F08976 complement(833390..834211) some similarities with uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response KLLA0F08998g 0 834717 835637 ON 6 F08998 complement(834717..835637) similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 RNA exonuclease required for U4 snRNA maturation functions redundantly with Rnh70p in 5.8S rRNA maturation and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA member of RNase D family of exonucleases Klac_YGOB_Anc_8.34 1 836287 841004 ON 6 Anc_8.34 (836287..839007,839010..841004) ANNOTATED BY YGOB - KLLA0F09053g 1 842591 843949 ON 6 F09053 (842591..843949) similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A has multiple roles in mitosis and protein biosynthesis found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells) KLLA0F09075g 0 844701 845084 ON 6 F09075 complement(844701..845084) highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain not essential for cytochrome c oxidase activity but may modulate activity in response to ATP KLLA0F09097g 0 846171 847745 ON 6 F09097 complement(846171..847745) similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation expression is induced in starved MATa/MAT alpha diploid cells KLLA0F09119g 1 848467 849825 ON 6 F09119 (848467..849825) highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails subunit of the Set3 complex a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity KLLA0F09141g 0 850288 851358 ON 6 F09141 complement(850288..851358) uniprot|Q8J0C9 Kluyveromyces lactis KLLA0F09141g gdp1 NADP glyceraldehyde 3-phosphate dehydrogenase KLLA0F09163g 0 852529 853803 ON 6 F09163 complement(852529..853803) similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative hydroxyacid dehydrogenase KLLA0F09185g 1 854314 855651 ON 6 F09185 (854314..855651) highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins KLLA0F09207g 1 856056 856343 ON 6 F09207 (856056..856343) highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Component of small nuclear ribonucleoprotein complexes involved in RNA processing splicing and decay KLLA0F09229g 0 856467 856856 ON 6 F09229 complement(856467..856856) similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Hypothetical ORF KLLA0F09251g 0 857154 857921 ON 6 F09251 complement(857154..857921) conserved hypothetical protein KLLA0F09273g 1 858627 859655 ON 6 F09273 (858627..859655) highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Delta-aminolevulinate dehydratase a homo-octameric enzyme catalyzes the conversion of delta- aminolevulinic acid to porphobilinogen the second step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus KLLA0F09295g 0 860011 860676 ON 6 F09295 complement(860011..860676) similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 vaculolar protein sorting (putative) KLLA0F09317g 1 861757 863238 ON 6 F09317 (861757..863238) similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase catalyzes the synthesis of cystathionine from serine and homocysteine the first committed step in cysteine biosynthesis KLLA0F09339g 0 863495 863920 ON 6 F09339 complement(863495..863920) similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Identified by expression profiling and mass spectrometry KLLA0F09361g 0 864425 865303 ON 6 F09361 complement(864425..865303) similar to uniprot|P07273 YGL043W Saccharomyces cerevisiae DST1 General transcription elongation factor TFIIS KLLA0F09383g 1 865710 866486 ON 6 F09383 (865710..866486) similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p KLLA0F09405g 1 867882 869513 ON 6 F09405 (867882..869513) similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Hypothetical ORF, member of the Dal5p subfamily of the major facilitator family KLLA0F09427g 0 869664 871307 ON 6 F09427 complement(869664..871307) weakly similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C KLLA0F09449g 1 872881 874605 ON 6 F09449 (872881..874605) highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL Klac_6.trna5P 0 874920 875041 ON 6 tP-UGG complement(874920..874955,875006..875041) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 59.72 KLLA0F09526g 1 875250 876263 ON 6 F09526 (875250..876263) similar to uniprot|Q75EB2 Ashbya gossypii AAR165W AAR165Wp and weakly similar to YGL126W uniprot|P53012 Saccharomyces cerevisiae SCS3 Protein required for inositol prototrophy KLLA0F09559g 0 876719 878695 ON 6 F09559 complement(876719..878695) some similarities with uniprot|P35995 Saccharomyces cerevisiae YKL222c KLLA0F09581g 0 879983 881536 ON 6 F09581 complement(879983..881536) similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Hypothetical ORF KLLA0F09603g 0 882778 883842 ON 6 F09603 complement(882778..883842) highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex which is an evolutionarily- conserved multi-protein complex found in mitochondria KLLA0F09625g 0 884902 886395 ON 6 F09625 complement(884902..886395) weakly similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosine-DNA Phosphodiesterase KLLA0F09647g 1 887288 889102 ON 6 F09647 (887288..889102) similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Isozyme of methylenetetrahydrofolate reductase catalyzes the reduction of 5 10- methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway KLLA0F09669g 1 890193 892073 ON 6 F09669 (890193..892073) similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Hypothetical ORF KLLA0F09691g 0 892208 893725 ON 6 F09691 complement(892208..893725) similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1 KLLA0F09713g 1 894192 895058 ON 6 F09713 (894192..895058) similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex with Slx4p that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks function overlaps with that of Sgs1p-Top3p KLLA0F09735g 0 895086 897818 ON 6 F09735 complement(895086..897818) similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis mutations in rot2 suppress tor2 mutations and are synthetically lethal with rot1 mutations KLLA0F09757g 1 898398 899156 ON 6 F09757 (898398..899156) some similarities with uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p KLLA0F09768g 0 899099 900685 ON 6 F09768 complement(899099..900685) weakly similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt- vesicles and autophagosomes with the vacuole associates as a complex with Ccz1p with a perivacuolar compartment potential Cdc28p substrate KLLA0F09790g 0 901211 901738 ON 6 F09790 complement(901211..901738) conserved hypothetical protein KLLA0F09812g 1 903154 903933 ON 6 F09812 (903154..903933) similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2 KLLA0F09845g 0 904512 906080 ON 6 F09845 complement(904512..906080) similar to uniprot|Q75E99 Ashbya gossypii AAR178C AAR178Cp and some similarites with YGL122C uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein related to human hnRNPs has a nuclear localization signal sequence that binds to Kap104p required for both poly(A) tail length control and nuclear export of mRNA KLLA0F09867g 0 906641 907750 ON 6 F09867 complement(906641..907750) no similarity KLLA0F09889g 1 907978 911079 ON 6 F09889 (907978..911079) uniprot|Q00976 Kluyveromyces lactis KLLA0F09889g SPT16 FACT complex subunit SPT16 KLLA0F09911g 0 911305 916269 ON 6 F09911 complement(911305..916269) highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 vesicle coat protein presumed vesicle coat protein KLLA0F09933g 1 918014 920224 ON 6 F09933 (918014..920224) similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase involved in the fatty acid beta-oxidation pathway localized to the peroxisomal matrix KLLA0F09955g 1 920896 921720 ON 6 F09955 (920896..921720) similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 phosphatidylserine synthase KLLA0F09977g 1 922726 923340 ON 6 F09977 (922726..923340) no similarity KLLA0F09999g 0 923413 925341 ON 6 F09999 complement(923413..925341) similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor cleaves Lys and Arg residues from the C-terminus of peptides and proteins KLLA0F10021g 1 926569 928062 ON 6 F10021 (926569..928062) similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase expression is regulated by general control of amino acid biosynthesis KLLA0F10043g 0 928691 930277 ON 6 F10043 complement(928691..930277) uniprot|Q701Q9 Kluyveromyces lactis KLLA0F10043g jen2 Carboxylic acid permease KLLA0F10065g 0 931989 934694 ON 6 F10065 complement(931989..934694) highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen activity is regulated by cyclic AMP-mediated phosphorylation expression is regulated by stress-response elements and by the HOG MAP kinase pathway KLLA0F10087g 0 935618 938629 ON 6 F10087 complement(935618..938629) similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex KLLA0F10109g 0 939195 941066 ON 6 F10109 complement(939195..941066) weakly similar to uniprot|Q00947 Saccharomyces cerevisiae YDR463W STP1 Transcription factor activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids activates transcription of amino acid permease genes and may have a role in tRNA processing KLLA0F10131g 0 942082 943392 ON 6 F10131 complement(942082..943392) similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8 KLLA0F10153g 1 943788 944348 ON 6 F10153 (943788..944348) similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Hypothetical ORF KLLA0F10175g 0 944501 946231 ON 6 F10175 complement(944501..946231) similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization KLLA0F10198g 1 946952 947194 ON 6 F10198 (946952..947194) no similarity KLLA0F10219g 1 948000 948467 ON 6 F10219 (948000..948467) similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Hypothetical ORF KLLA0F10241g 0 948591 949121 ON 6 F10241 complement(948591..949121) similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Protein that forms a complex with Lrs4p located in the nucleolus Lrs4p-Csm1p heterodimer binds to Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation may be involved in premeiotic DNA replication KLLA0F10263g 1 949926 951974 ON 6 F10263 (949926..951974) uniprot|P56094 Kluyveromyces lactis KLLA0F10263g TUP1 Transcriptional repressor TUP1 KLLA0F10285g 0 952632 953825 ON 6 F10285 complement(952632..953825) similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase essential enzyme involved in the biosynthesis of isoprenoids and sterols including ergosterol acts as a homodimer KLLA0F10307g 1 954558 955673 ON 6 F10307 (954558..955673) similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis KLLA0F10329g 0 955834 956634 ON 6 F10329 complement(955834..956634) similar to uniprot|Q751D6 Ashbya gossypii AGL230C AGL230Cp and weakly similar to YNR040W uniprot|P53736 Saccharomyces cerevisiae YNR040W Hypothetical ORF KLLA0F10351g 0 956981 957400 ON 6 F10351 complement(956981..957400) similar to uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 mitochondrial thioredoxin KLLA0F10373g 1 957948 958994 ON 6 F10373 (957948..958994) some similarities with uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type probable transcriptional activator of thiamine biosynthetic genes KLLA0F10395g 0 959120 960238 ON 6 F10395 complement(959120..960238) similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p) delivering tRNA to them stimulating catalysis and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids KLLA0F10417g 1 961004 962527 ON 6 F10417 (961004..962527) similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C Hypothetical ORF KLLA0F10439g 0 962683 963111 ON 6 F10439 complement(962683..963111) highly similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for myosin Myo2p may stabilize Myo2p by binding to the neck region may interact with Myo1p Iqg1p and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition KLLA0F10461g 1 964030 966024 ON 6 F10461 (964030..966024) similar to uniprot|P38330 Saccharomyces cerevisiae YBR238C Hypothetical ORF KLLA0F10483g 1 966417 966701 ON 6 F10483 (966417..966701) similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function KLLA0F10505g 0 966736 969174 ON 6 F10505 complement(966736..969174) similar to uniprot|Q754U8 Ashbya gossypii AFL027C PRP5 Pre-mRNA-processing ATP-dependent RNA helicase PRP5 and weakly similar to YBR237W uniprot|P21372 Saccharomyces cerevisiae PRP5 RNA helicase in the DEAD-box family KLLA0F10527g 1 969804 971084 ON 6 F10527 (969804..971084) similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA KLLA0F10549g 0 971178 974453 ON 6 F10549 complement(971178..974453) similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Hypothetical ORF KLLA0F10571g 1 974719 976602 ON 6 F10571 (974719..976602) similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function has a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination KLLA0F10593g 0 976698 978008 ON 6 F10593 complement(976698..978008) similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis KLLA0F10615g 1 978492 979604 ON 6 F10615 (978492..979604) highly similar to uniprot|Q754U3 Ashbya gossypii AFL022W AFL022Wp and similar to YBR234C uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Essential subunit of the ARP2/3 complex which is required for the motility and integrity of cortical actin patches KLLA0F10637g 0 979795 980052 ON 6 F10637 complement(979795..980052) similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential protein component of the DASH complex involved in spindle integrity and kinetochore function interacts with Duo1p and Dam1p localizes to intranuclear spindles and kinetochore KLLA0F10659g 1 980423 981973 ON 6 F10659 (980423..981973) similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes KLLA0F10681g 0 982014 983909 ON 6 F10681 complement(982014..983909) weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein that interacts with Cdc45p in initiation of DNA replication gene exhibits synthetic lethality with dpb11-1 KLLA0F10703g 0 984298 985551 ON 6 F10703 complement(984298..985551) similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W KLLA0F10725g 1 985843 986790 ON 6 F10725 (985843..986790) similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin KLLA0F10747g 0 986879 989077 ON 6 F10747 complement(986879..989077) similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative member of the oligopeptide transporter (OPT) family of membrane transporters KLLA0F10769g 0 989640 990626 ON 6 F10769 complement(989640..990626) uniprot|Q9P869 Kluyveromyces lactis Nuclear protein SNF4 KLLA0F10791g 0 991642 993279 ON 6 F10791 complement(991642..993279) similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase- promoting complex/cyclosome (APC/C) which is required for metaphase/anaphase transition directs ubiquitination of mitotic cyclins Pds1p and other anaphase inhibitors potential Cdc28p substrate KLLA0F10813g 0 993942 995270 ON 6 F10813 complement(993942..995270) similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W Hypothetical ORF KLLA0F10835g 1 997512 999782 ON 6 F10835 (997512..999782) conserved hypothetical protein KLLA0F10857g 1 1000899 1001525 ON 6 F10857 (1000899..1001525) weakly similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Hypothetical ORF KLLA0F10879g 0 1001626 1002840 ON 6 F10879 complement(1001626..1002840) similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids KLLA0F10912g 1 1003827 1007678 ON 6 F10912 (1003827..1007678) some similarities with uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin nucleates the formation of linear actin filaments involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables functionally redundant with BNI1 KLLA0F10934g 1 1008727 1009773 ON 6 F10934 (1008727..1009773) weakly similar to uniprot|P36169 Saccharomyces cerevisiae YKR100C SKG1 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud KLLA0F10956g 0 1010089 1010631 ON 6 F10956 complement(1010089..1010631) similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C FMP35 The authentic non-tagged protein was localized to the mitochondria KLLA0F10967g 1 1010911 1011286 ON 6 F10967 (1010911..1010919,1011074..1011286) highly similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B KLLA0F10978g 0 1011479 1013788 ON 6 F10978 complement(1011479..1013788) similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways KLLA0F11000g 1 1014492 1016159 ON 6 F11000 (1014492..1016159) similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates specifically required for cell cycle progression associates with nucleoporins and may interact with septin rings during telophase KLLA0F11022g 0 1016214 1018880 ON 6 F11022 complement(1016214..1018880) similar to uniprot|P40965 Saccharomyces cerevisiae YFL003C MSH4 Protein involved in meiotic recombination required for normal levels of crossing over colocalizes with Zip2p to discrete foci on meiotic chromosomes has homology to bacterial MutS protein KLLA0F11033g 0 1018877 1019887 ON 6 F11033 complement(1018877..1019887) similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD( )-dependent protein deacetylases modulates nucleolar (rDNA) and telomeric silencing possesses NAD( )-dependent histone deacetylase activity in vitro Klac_6.trna6N 0 1020157 1020230 ON 6 tN-GUU complement(1020157..1020230) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 KLLA0F11077g 1 1021058 1022797 ON 6 F11077 (1021058..1022797) weakly similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane KLLA0F11099g 0 1022939 1024666 ON 6 F11099 complement(1022939..1024666) weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain acts in the cytoplasmic dynein pathway forms cortical cytoplasmic microtubule capture site with Num1p null mutant is defective in nuclear migration essential in the absence of CIN8 KLLA0F11121g 1 1024978 1025856 ON 6 F11121 (1024978..1025856) similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p Psf1p Psf2p Psf3p) which binds to DNA replication origins and facilitates assembly of the DNA replication machinery KLLA0F11143g 0 1026129 1028570 ON 6 F11143 complement(1026129..1028570) similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase required for cell-cycle arrest in response to DNA damage activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p KLLA0F11165g 1 1030159 1031397 ON 6 F11165 (1030159..1031397) similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase catalyzes the terminal step of triacylglycerol (TAG) formation acylates diacylglycerol using acyl-CoA as an acyl donor localized to lipid particles KLLA0F11187g 1 1031839 1032921 ON 6 F11187 (1031839..1032921) similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Resistant to Rapamycin Deletion 2; similar to hosphotyrosyl phosphatase activator (PTPA) from several organisms KLLA0F11209g 0 1033024 1034343 ON 6 F11209 complement(1033024..1034343) highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail required for cell cycle progression KLLA0F11231g 0 1034708 1036012 ON 6 F11231 complement(1034708..1036012) similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Splicing factor that is found in the Cef1p subcomplex of the spliceosome KLLA0F11253g 1 1036274 1038304 ON 6 F11253 (1036274..1038304) similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 pseudouridylates U2 snRNA at position 35 KLLA0F11275g 1 1038770 1039927 ON 6 F11275 (1038770..1039927) weakly similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation SPecific involved in sporulation KLLA0F11297g 0 1040048 1041529 ON 6 F11297 complement(1040048..1041529) similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase catalyzes extension of the glutamate chains of the folate coenzymes required for methionine synthesis and for maintenance of mitochondrial DNA present in both the cytoplasm and mitochondria KLLA0F11319g 1 1042436 1044967 ON 6 F11319 (1042436..1044967) similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Hypothetical ORF KLLA0F11341g 0 1045057 1046616 ON 6 F11341 complement(1045057..1046616) conserved hypothetical protein KLLA0F11363g 1 1046847 1047662 ON 6 F11363 (1046847..1047662) similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation KLLA0F11385g 0 1047731 1048795 OFF 6 F11385 complement(1047731..1048795) similar to uniprot|Q08641 Saccharomyces cerevisiae YOR239W/YOR240W Klac_YGOB_F11386g 0 1047731 1049333 ON 6 F11386g complement(1047731..1048744,1048746..1049333) ANNOTATED BY YGOB - KLLA0F11396g 0 1048734 1049333 OFF 6 F11396 complement(1048734..1049333) no similarity KLLA0F11418g 0 1049704 1050210 ON 6 F11418 complement(1049704..1050210) weakly similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase) activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation KLLA0F11440g 0 1050417 1051088 ON 6 F11440 complement(1050417..1051088) conserved hypothetical protein KLLA0F11462g 0 1051409 1052272 ON 6 F11462 complement(1051409..1052272) conserved hypothetical protein KLLA0F11484g 1 1052991 1055528 ON 6 F11484 (1052991..1055528) similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes ABC family long-chain fatty acid transporter KLLA0F11506g 0 1055769 1057103 ON 6 F11506 complement(1055769..1057103) similar to uniprot|Q75BZ3 Ashbya gossypii ACR126W ACR126Wp and some similarites with YPL146C uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein involved in biogenesis of the 60S subunit of the ribosome interacts with rRNA processing factors Cbf5p and Nop2p null mutant is viable but growth is severely impaired KLLA0F11528g 0 1057527 1059788 ON 6 F11528 complement(1057527..1059788) weakly similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W KLLA0F11550g 1 1060194 1061885 ON 6 F11550 (1060194..1061885) some similarites with uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 PHO85 Requiring KLLA0F11572g 0 1061995 1063788 ON 6 F11572 complement(1061995..1063788) weakly similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p Klac_6.trna7R 0 1064233 1064322 ON 6 tR-ACG complement(1064233..1064268,1064286..1064322) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 65.75 KLLA0F11638g 1 1064635 1065051 ON 6 F11638 (1064635..1065051) similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Protein with a potential role in actin cytoskeleton organization possible component of the TOR nutrient signaling pathway gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4- phosphate kinase KLLA0F11660g 1 1065656 1067533 ON 6 F11660 (1065656..1067533) some similarities with uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex KLLA0F11682g 0 1068992 1070116 ON 6 F11682 complement(1068992..1070116) weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF KLLA0F11704g 1 1074845 1077886 ON 6 F11704 (1074845..1077886) similar to uniprot|Q750Z5 Ashbya gossypii AGL208C AGL208Cp and some similarites with YNR067C uniprot|P53753 Saccharomyces cerevisiae KLLA0F11726g 1 1080554 1082773 ON 6 F11726 (1080554..1082773) conserved hypothetical protein KLLA0F11748g 0 1082975 1085716 ON 6 F11748 complement(1082975..1085716) similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Hypothetical ORF KLLA0F11770g 1 1086389 1087498 ON 6 F11770 (1086389..1087498) highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase catalyzes the fifth step in the heme biosynthetic pathway localizes to both the cytoplasm and nucleus activity inhibited by Cu2 Zn2 Fe2 Fe3 and sulfhydryl-specific reagents KLLA0F11792g 1 1087802 1089667 ON 6 F11792 (1087802..1089667) similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W Hypothetical ORF KLLA0F11814g 0 1089699 1092494 ON 6 F11814 complement(1089699..1092494) similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase stimulates strand exchange by modifying the topology of double-stranded DNA involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis proposed to be involved in crossover interference Klac_6.trna8I 1 1092866 1092939 ON 6 tI-AAU (1092866..1092939) tRNA Type: Ile (I) | Anti-Codon: AAU | Cove Score: 72.37 Klac_YGOB_Anc_8.253 1 1093248 1093472 ON 6 Anc_8.253 (1093248..1093472) ANNOTATED BY YGOB - KLLA0F11891g 1 1093680 1094537 ON 6 F11891 (1093680..1094537) conserved hypothetical protein KLLA0F11913g 0 1094612 1095373 ON 6 F11913 complement(1094612..1095373) weakly similar to uniprot|Q04549 Saccharomyces cerevisiae YDR106W ARP10 Actin-related protein KLLA0F11935g 1 1095626 1097038 ON 6 F11935 (1095626..1097038) similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Putative membrane protein conserved in mammals KLLA0F11957g 0 1097165 1098154 ON 6 F11957 complement(1097165..1098154) highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes homolog of Rad51p and the bacterial RecA protein KLLA0F11979g 0 1098706 1100421 ON 6 F11979 complement(1098706..1100421) uniprot|Q6CKB6 Kluyveromyces lactis KLLA0F11979g ARX1 Probable metalloprotease ARX1 KLLA0F12001g 1 1101429 1102667 ON 6 F12001 (1101429..1102667) uniprot|O13366 Kluyveromyces lactis KLLA0F12001g PDA1 Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial precursor KLLA0F12023g 1 1103908 1106148 ON 6 F12023 (1103908..1106148) some similarities with uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Scaffold protein that in response to pheromone shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p Ste7p and Fus3p into a specific signaling complex active oligomeric form interacts with Ste4p-Ste18p complex KLLA0F12034g 0 1106143 1109412 ON 6 F12034 complement(1106143..1109412) similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis KLLA0F12056g 0 1109801 1110886 ON 6 F12056 complement(1109801..1110886) similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W KLLA0F12078g 0 1111445 1111867 ON 6 F12078 complement(1111445..1111867) weakly similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Tlg2-Vesicle Protein of 15 kDa; integral membrane vesicle protein KLLA0F12100g 0 1113803 1114555 ON 6 F12100 complement(1113803..1114555) highly similar to uniprot|P29311 Saccharomyces cerevisiae YER177W BMH1 14-3-3 protein major isoform binds proteins and DNA involved in regulation of many processes including exocytosis and vesicle transport Ras/MAPK signaling during pseudohyphal development rapamycin- sensitive signaling and others Klac_6.trna9L 1 1116489 1116604 ON 6 tL-CAA (1116489..1116526,1116561..1116604) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 55.30 KLLA0F12166g 0 1116715 1121301 ON 6 F12166 complement(1116715..1121301) similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C Hypothetical ORF KLLA0F12188g 1 1122745 1124385 ON 6 F12188 (1122745..1124385) some similarities with uniprot|P38623 Saccharomyces cerevisiae YLR248W RCK2 Protein kinase involved in the response to oxidative stress identified as suppressor of S. pombe cell cycle checkpoint mutations KLLA0F12210g 1 1125630 1128764 ON 6 F12210 (1125630..1128764) highly similar to uniprot|P16521 Saccharomyces cerevisiae YLR249W YEF3 stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex contains two ABC cassettes and binds and hydrolyses ATP EF-3 (translational elongation factor 3) KLLA0F12232g 1 1129199 1131337 ON 6 F12232 (1129199..1129312,1129532..1131337) similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W KLLA0F12254g 1 1131646 1132320 ON 6 F12254 (1131646..1132320) similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0F12276g 0 1132386 1133648 ON 6 F12276 complement(1132386..1133648) similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Hypothetical ORF KLLA0F12298g 1 1133900 1134574 ON 6 F12298 (1133900..1134574) similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Hypothetical ORF KLLA0F12342g 1 1137608 1138855 ON 6 F12342 (1137608..1138855) highly similar to uniprot|P41939 Saccharomyces cerevisiae YLR174W IDP2 Cytosolic NADP-specific isocitrate dehydrogenase catalyzes oxidation of isocitrate to alpha- ketoglutarate levels are elevated during growth on non- fermentable carbon sources and reduced during growth on glucose KLLA0F12364g 1 1139357 1140241 ON 6 F12364 (1139357..1140241) highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase which catalyzes the first step of branched-chain amino acid biosynthesis enhances activity of the Ilv2p catalytic subunit localizes to mitochondria KLLA0F12386g 0 1140511 1141605 ON 6 F12386 complement(1140511..1141605) uniprot|P48535 Kluyveromyces lactis RM02 60S RIBOSOMAL PROTEIN L2, MITOCHONDRIAL PRECURSOR KLLA0F12408g 1 1142235 1142975 ON 6 F12408 (1142235..1142975) similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 SaGa associated Factor 29kDa Probable 29kKDa Subunit of SAGA histone acetyltransferase complex Klac_YGOB_YGL194C-A 1 1143195 1143452 ON 6 YGL194C-A (1143195..1143452) ANNOTATED BY YGOB - KLLA0F12430g 0 1143594 1151609 ON 6 F12430 complement(1143594..1151609) similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity forms a complex with Gcn20p proposed to stimulate Gcn2p activation by an uncharged tRNA KLLA0F12452g 0 1152209 1156510 ON 6 F12452 complement(1152209..1156510) some similarities with uniprot|P53094 Saccharomyces cerevisiae YGL197W MDS3 Protein with an N-terminal kelch- like domain putative negative regulator of early meiotic gene expression required with Pmd1p for growth under alkaline conditions KLLA0F12474g 0 1157066 1157704 ON 6 F12474 complement(1157066..1157704) similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle- mediated transport KLLA0F12496g 1 1159546 1160481 ON 6 F12496 (1159546..1160481) highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Catalytic subunit of type 1 serine/threonine protein phosphatase involved in many processes including glycogen metabolism sporulation and mitosis interacts with multiple regulatory subunits predominantly isolated with Sds22p KLLA0F12518g 1 1161207 1161806 ON 6 F12518 (1161207..1161806) highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles which function in ER to Golgi transport KLLA0F12540g 1 1162739 1163116 ON 6 F12540 (1162739..1163116) similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 subunit of UAF (upstream activation factor) involved in promoting high level transcription of rDNA Upstream activation factor subunit KLLA0F12562g 1 1163366 1165480 ON 6 F12562 (1163366..1165480) highly similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W KLLA0F12584g 0 1165710 1168343 ON 6 F12584 complement(1165710..1168343) highly similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex KLLA0F12606g 1 1169080 1170159 ON 6 F12606 (1169080..1170159) conserved hypothetical protein KLLA0F12628g 0 1170396 1171910 ON 6 F12628 complement(1170396..1171910) similar to uniprot|P38067 Saccharomyces cerevisiae YBR006w UGA2 succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source KLLA0F12650g 0 1172232 1173806 ON 6 F12650 complement(1172232..1173806) similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Hypothetical ORF KLLA0F12672g 1 1174064 1174699 ON 6 F12672 (1174064..1174699) similar to uniprot|P40084 Saccharomyces cerevisiae YER139C Hypothetical ORF KLLA0F12694g 0 1174812 1175954 ON 6 F12694 complement(1174812..1175954) weakly similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W Hypothetical ORF Klac_6.trna10V 1 1176163 1176236 ON 6 tV-AAC (1176163..1176236) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 Klac_6.trna11P 1 1176653 1176724 ON 6 tP-AGG (1176653..1176724) tRNA Type: Pro (P) | Anti-Codon: AGG | Cove Score: 71.39 KLLA0F12760g 1 1177776 1179224 ON 6 F12760 (1177776..1179224) highly similar to uniprot|P00890 Saccharomyces cerevisiae YNR001C CIT1 Citrate synthase catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate the rate-limiting enzyme of the TCA cycle nuclear encoded mitochondrial protein KLLA0F12782g 1 1180049 1180777 ON 6 F12782 (1180049..1180777) similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0F12804g 0 1180909 1182651 ON 6 F12804 complement(1180909..1182651) conserved hypothetical protein KLLA0F12826g 0 1183130 1183687 ON 6 F12826 complement(1183130..1183687) similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit KLLA0F12848g 1 1184231 1185244 ON 6 F12848 (1184231..1185244) highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM Klac_CEN6 1 1187015 1187211 ON 6 CEN6 (1187015..1187211) Chromosome VI centromere KLLA0F12892g 0 1187526 1189853 ON 6 F12892 complement(1187526..1189853) highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur also participates in endocytosis KLLA0F12914g 0 1190220 1191512 ON 6 F12914 complement(1190220..1191512) similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Regulator of Ty1 Transposition Regulation of mitochondrial network Killed in Mutagen sensitive to diepoxybutane and/or mitomycin C diepoxybutane and mitomycin C resistance KLLA0F12936g 0 1191839 1192590 ON 6 F12936 complement(1191839..1192421,1192526..1192590) highly similar to uniprot|P38624 YJL001W Saccharomyces cerevisiae PRE3 20S proteasome beta-type subunit KLLA0F12958g 0 1192881 1195799 ON 6 F12958 complement(1192881..1195799) weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1 KLLA0F12980g 1 1196141 1197526 ON 6 F12980 (1196141..1197526) similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen which catalyzes asparagine-linked glycosylation of newly synthesized proteins KLLA0F13002g 0 1197689 1199593 ON 6 F13002 complement(1197689..1199593) similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing KLLA0F13024g 0 1199854 1200210 ON 6 F13024 complement(1199854..1200210) highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase KLLA0F13046g 1 1201353 1205492 ON 6 F13046 (1201353..1205492) weakly similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Positive transcriptional regulator controls the expression of ADH2 peroxisomal protein genes and genes required for ethanol glycerol and fatty acid utilization KLLA0F13068g 0 1205686 1208568 ON 6 F13068 complement(1205686..1208568) weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein required for cell-cycle arrest in G1/S intra-S and G2/M transmits checkpoint signal by activating Rad53p and Chk1p hyperphosphorylated by Mec1p and Tel1p potential Cdc28p substrate KLLA0F13090g 1 1209397 1210491 ON 6 F13090 (1209397..1210491) some similarities with uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Component of the meiotic outer plaque KLLA0F13112g 0 1210588 1211760 ON 6 F13112 complement(1210588..1211760) similar to uniprot|Q04921 Saccharomyces cerevisiae YDR218C SPR28 Septin-related protein expressed during sporulation KLLA0F13134g 0 1212025 1213209 ON 6 F13134 complement(1212025..1213209) similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II KLLA0F13156g 0 1213540 1215087 ON 6 F13156 complement(1213540..1215087) some similarities with uniprot|Q04922 Saccharomyces cerevisiae YDR219C Hypothetical ORF KLLA0F13178g 1 1215760 1217748 ON 6 F13178 (1215760..1217748) weakly similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W Hypothetical ORF KLLA0F13200g 1 1218634 1219926 ON 6 F13200 (1218634..1219926) similar to uniprot|Q04925 YDR222W Saccharomyces cerevisiae Protein of unknown function KLLA0F13222g 1 1220679 1223633 ON 6 F13222 (1220679..1223633) weakly similar to uniprot|P39520 Saccharomyces cerevisiae YLR223C IFH1 Essential protein with a highly acidic N-terminal domain IFH1 exhibits genetic interactions with FHL1 overexpression interferes with silencing at telomeres and HM loci potential Cdc28p substrate KLLA0F13244g 1 1224178 1226622 ON 6 F13244 (1224178..1226622) highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA KLLA0F13266g 1 1226962 1227573 ON 6 F13266 (1226962..1227573) weakly similar to uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation required for accumulation of wild- type levels of large (60S) ribosomal subunits binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus KLLA0F13288g 0 1227828 1228739 ON 6 F13288 complement(1227828..1228739) similar to uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Functions in the homeostasis of both calcium and manganese ions Possible transmembrane Ca2 transporter KLLA0F13310g 0 1229619 1230017 ON 6 F13310 complement(1229619..1230017) similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation meiotic DSB formation and H3 methylation and similar to YBL002W uniprot|P02294 Saccharomyces cerevisiae YBL002W HTB2 One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation KLLA0F13332g 1 1230744 1231136 ON 6 F13332 (1230744..1231136) similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 One of two nearly identical (see also HTA2) histone H2A subtypes core histone required for chromatin assembly and chromosome function DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair acetylated by Nat4p and similar to YBL003C uniprot|P04912 Saccharomyces cerevisiae YBL003C HTA2 One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage- dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p KLLA0F13354g 0 1231619 1233577 ON 6 F13354 complement(1231619..1233577) weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids potential Cdc28p substrate KLLA0F13376g 1 1234589 1235272 ON 6 F13376 (1234589..1235272) highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 adenylate kinase KLLA0F13398g 1 1236895 1239399 ON 6 F13398 (1236895..1239399) no similarity KLLA0F13420g 1 1240135 1244145 ON 6 F13420 (1240135..1244145) uniprot|O59904 Kluyveromyces lactis SIR4 Silent information regulator 4 KLLA0F13442g 0 1244416 1246179 ON 6 F13442 complement(1244416..1246179) similar to uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor essential component of cleavage and polyadenylation factor IA (CF IA) involved in pre-mRNA 3' end processing and in transcription termination binds C-terminal domain of largest subunit of RNA pol II (Rpo21p) KLLA0F13464g 1 1246646 1247548 ON 6 F13464 (1246646..1247548) highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family (putative) mitochondrial carrier protein KLLA0F13486g 0 1247633 1248457 ON 6 F13486 complement(1247633..1248457) some similarities with uniprot|P34246 Saccharomyces cerevisiae YKL098W Hypothetical ORF KLLA0F13508g 1 1248753 1249502 ON 6 F13508 (1248753..1249502) similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0F13530g 1 1251162 1252289 ON 6 F13530 (1251162..1252289) uniprot|P49385 Kluyveromyces lactis ADH4 Alcohol dehydrogenase IV, mitochondrial precursor KLLA0F13552g 0 1252906 1256709 ON 6 F13552 complement(1252906..1256709) weakly similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints associates with the assembled septin filament required along with Hsl7p for bud neck recruitment phosphorylation and degradation of Swe1p KLLA0F13574g 1 1257682 1259241 ON 6 F13574 (1257682..1259241) similar to uniprot|P14904 YKL103C Saccharomyces cerevisiae LAP4 Vacuolar aminopeptidase KLLA0F13596g 1 1259744 1261858 ON 6 F13596 (1259744..1261858) highly similar to uniprot|P14742 Saccharomyces cerevisiae YKL104C GFA1 Glutamine-fructose-6-phosphate amidotransferase catalyzes the formation of glucosamine-6- P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis KLLA0F13618g 1 1262308 1264575 ON 6 F13618 (1262308..1264575) some similarities with uniprot|Q04279 Saccharomyces cerevisiae YMR086W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and uniprot|P34250 Saccharomyces cerevisiae YKL105C KLLA0F13640g 0 1264781 1266037 ON 6 F13640 complement(1264781..1266037) similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis KLLA0F13662g 1 1266539 1267276 ON 6 F13662 (1266539..1267276) similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose may have a role in tRNA splicing contains an A1pp domain KLLA0F13684g 0 1267367 1269082 ON 6 F13684 complement(1267367..1269082) similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane KLLA0F13706g 0 1269550 1272078 ON 6 F13706 complement(1269550..1272078) similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component with Afg3p of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes KLLA0F13728g 0 1272497 1273759 ON 6 F13728 complement(1272497..1273759) similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Nuclear protein that may have a role in nuclear protein import KLLA0F13750g 0 1274110 1275972 ON 6 F13750 complement(1274110..1275972) similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component probable binding site on actin lies on front surface of subdomains 3 and 4 KLLA0F13772g 1 1276532 1278094 ON 6 F13772 (1276532..1278094) highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0F13794g 0 1278244 1279446 ON 6 F13794 complement(1278244..1279446) similar to uniprot|Q75DR2 Ashbya gossypii ABL045W and weakly similar to YKL108W uniprot|P34252 Saccharomyces cerevisiae SLD2 Protein required for DNA replication KLLA0F13816g 1 1279517 1280686 ON 6 F13816 (1279517..1280686) weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex which binds to the CDE III element of centromeres bending the DNA upon binding and may be involved in sister chromatid cohesion during mitosis KLLA0F13838g 0 1281316 1283247 ON 6 F13838 complement(1281316..1283247) uniprot|O94233 Kluyveromyces lactis HAP4 KLLA0F13860g 1 1284278 1284697 ON 6 F13860 (1284278..1284697) similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W KLLA0F13882g 1 1286151 1287647 ON 6 F13882 (1286151..1287647) similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Hypothetical ORF KLLA0F13904g 0 1287758 1289497 ON 6 F13904 complement(1287758..1289497) similar to uniprot|P42950 Saccharomyces cerevisiae YJL103C Hypothetical ORF KLLA0F13926g 0 1290006 1292228 ON 6 F13926 complement(1290006..1292228) similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis KLLA0F13948g 1 1292876 1293634 ON 6 F13948 (1292876..1293634) similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37 KLLA0F13970g 0 1293695 1294615 ON 6 F13970 complement(1293695..1294615) highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B the guanine-nucleotide exchange factor for eIF2 KLLA0F13981g 0 1294716 1294949 ON 6 F13981 complement(1294716..1294949) no similarity KLLA0F13992g 1 1295129 1297531 ON 6 F13992 (1295129..1297531) similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 mitochondrial elongation factor G-like protein Klac_6.trna12R 1 1297753 1297842 ON 6 tR-ACG (1297753..1297789,1297807..1297842) tRNA Type: Arg (R) | Anti-Codon: ACG | Cove Score: 65.75 KLLA0F14058g 0 1298078 1300075 ON 6 F14058 complement(1298078..1300075) similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis expression induced by oxidants cadmium and mercury KLLA0F14080g 1 1300876 1302420 ON 6 F14080 (1300876..1302420) similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Phosphatidylinositol 4-kinase that binds Las17p which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization KLLA0F14102g 1 1302743 1304893 ON 6 F14102 (1302743..1304893) similar to uniprot|P36122 Saccharomyces cerevisiae YKR027W FMP50 The authentic non-tagged protein was localized to the mitochondria and uniprot|P40955 Saccharomyces cerevisiae YJL099w CHS6 chitin biosynthesis protein KLLA0F14124g 1 1305690 1308992 ON 6 F14124 (1305690..1308992) similar to uniprot|P36123 Saccharomyces cerevisiae or to YJL098W uniprot|P40856 Saccharomyces cerevisiae YJL098W KLLA0F14146g 1 1309358 1310002 ON 6 F14146 (1309358..1310002) similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W Protein required for cell viability KLLA0F14168g 1 1310321 1310803 ON 6 F14168 (1310321..1310803) some similarities with uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit KLLA0F14190g 1 1311121 1315137 ON 6 F14190 (1311121..1315137) uniprot|O60030 Kluyveromyces lactis BCK1 MAP kinase kinase kinase KLLA0F14212g 0 1315326 1317212 ON 6 F14212 complement(1315326..1317212) weakly similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Target Of K1 Killer Toxin outward- rectifier potassium channel KLLA0F14234g 1 1317691 1320885 ON 6 F14234 (1317691..1320885) similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate KLLA0F14256g 1 1321231 1324131 ON 6 F14256 (1321231..1324131) similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W HPR5 DNA helicase and DNA-dependent ATPase involved in DNA repair required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II potential Cdc28p substrate KLLA0F14278g 0 1324216 1325556 ON 6 F14278 complement(1324216..1325556) similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI) an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors KLLA0F14300g 0 1325862 1327871 ON 6 F14300 complement(1325862..1327871) similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Essential BRCT repeat protein required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis also required for S/M checkpoint control KLLA0F14322g 1 1328925 1331078 ON 6 F14322 (1328925..1331078) uniprot|Q7Z8R2 Kluyveromyces lactis Sip4 protein KLLA0F14344g 1 1331407 1332261 ON 6 F14344 (1331407..1332261) weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C Protein required for cell viability KLLA0F14366g 1 1332595 1333599 ON 6 F14366 (1332595..1333599) similar to uniprot|P05150 YJL088W Saccharomyces cerevisiae ARG3 Ornithine carbamoyltransferase KLLA0F14399g 0 1333743 1336184 ON 6 F14399 complement(1333743..1336184) similar to uniprot|P09880 YJL087C Saccharomyces cerevisiae TRL1 tRNA ligase KLLA0F14421g 1 1336663 1338522 ON 6 F14421 (1336663..1338522) similar to uniprot|P19658 YJL085W Saccharomyces cerevisiae EXO70 Essential 70kDa subunit of the exocyst complex (Sec3p Sec5p Sec6p Sec8p Sec10p Sec15p Exo70p and Exo84p) KLLA0F14443g 0 1338526 1341213 ON 6 F14443 complement(1338526..1341213) some similarities with uniprot|P47029 Saccharomyces cerevisiae YJL084C Cytoplasmic protein of unknown function that interacts with Pcl7p phosphorylated in vitro potential Cdc28p substrate KLLA0F14465g 1 1341764 1344067 ON 6 F14465 (1341764..1344067) similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair subunit of Nuclear Excision Repair Factor 2 (NEF2) homolog of human XPC protein KLLA0F14487g 1 1344298 1345206 ON 6 F14487 (1344298..1345206) weakly similar to uniprot|P06843 Saccharomyces cerevisiae YER161c SPT2 multifunctional HMG-like chromatin protein KLLA0F14509g 0 1345334 1347889 ON 6 F14509 complement(1345334..1347889) similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Hypothetical ORF KLLA0F14531g 1 1349155 1350180 ON 6 F14531 (1349155..1350180) weakly similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 Protein involved in 3' splice site choices acts in concert with Prp18p during the 2nd step of splicing KLLA0F14553g 1 1350504 1351637 ON 6 F14553 (1350504..1351637) similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 RNA:Psi-synthase and weakly similar to YOL066C uniprot|Q12362 Saccharomyces cerevisiae YOL066C RIB2 DRAP deaminase, catalyzes the third step of the riboflavin biosynthesis pathway; N-terminus has sequence similarity to RNA:pseudouridine synthases KLLA0F14575g 0 1351796 1354351 ON 6 F14575 complement(1351796..1354351) some similarities with uniprot|P47068 Saccharomyces cerevisiae YJL020C/YJL021C BBC1 Protein possibly involved in assembly of actin patches KLLA0F14597g 1 1354637 1355674 ON 6 F14597 (1354637..1355674) weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Hypothetical ORF KLLA0F14619g 0 1355858 1356547 ON 6 F14619 complement(1355858..1356547) similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain KLLA0F14641g 0 1356788 1358071 ON 6 F14641 complement(1356788..1358071) weakly similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W KRE11 Protein involved in biosynthesis of cell wall beta-glucans subunit of the TRAPP (transport protein particle) complex which is involved in the late steps of endoplasmic reticulum to Golgi transport KLLA0F14663g 0 1358439 1360451 ON 6 F14663 complement(1358439..1360451) uniprot|P33294 Kluyveromyces lactis KLLA0F14663g SIR2 NAD-dependent histone deacetylase SIR2 KLLA0F14685g 0 1361016 1361636 ON 6 F14685 complement(1361016..1361636) similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria peroxisomes and nucleus KLLA0F14707g 1 1361964 1363268 ON 6 F14707 (1361964..1363268) highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates required for normal peptide hydrolysis by the core 20S particle KLLA0F14729g 1 1363888 1364736 ON 6 F14729 (1363888..1364736) highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C) inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p mutation delays mitochondrial inheritance deletion reveals defects in precursor tRNA splicing sporulation and cell separation KLLA0F14751g 0 1364995 1365837 ON 6 F14751 complement(1364995..1365837) weakly similar to uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex KLLA0F14773g 1 1366502 1366981 ON 6 F14773 (1366502..1366981) uniprot|P78700 Kluyveromyces lactis KLLA0F14773g ATP16 ATP synthase delta chain, mitochondrial precursor KLLA0F14795g 1 1368194 1369996 ON 6 F14795 (1368194..1369996) similar to uniprot|Q12158 Saccharomyces cerevisiae YDL003W MCD1 Essential protein required for sister chromatid cohesion in mitosis and meiosis KLLA0F14817g 0 1370109 1372292 ON 6 F14817 complement(1370109..1372292) similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Hypothetical ORF KLLA0F14839g 1 1372634 1373779 ON 6 F14839 (1372634..1373779) similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Protein of unknown function essential for viability may be involved in rRNA processing KLLA0F14861g 1 1375042 1376811 ON 6 F14861 (1375042..1376811) some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein component of the U1 snRNP protein KLLA0F14905g 1 1378784 1379626 ON 6 F14905 (1378784..1379626) conserved hypothetical protein KLLA0F14916g 0 1380006 1380278 ON 6 F14916 complement(1380006..1380278) similar to uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A KLLA0F14927g 1 1381250 1384360 ON 6 F14927 (1381250..1384360) weakly similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes converts phosphatidylserine to phosphatidylethanolamine KLLA0F14949g 1 1384656 1386121 ON 6 F14949 (1384656..1384681,1384759..1386121) similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W HYS2 DNA polymerase III (delta) 55 kDa subunit essential for cell viability involved in DNA replication and DNA repair KLLA0F14971g 0 1386169 1387875 ON 6 F14971 complement(1386169..1387875) similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p KLLA0F14993g 0 1388151 1389260 ON 6 F14993 complement(1388151..1389260) highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W KLLA0F15015g 1 1389925 1390728 ON 6 F15015 (1389925..1390728) similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Golgi integral membrane protein binds to the transport GTPases Ypt1p and Ypt31p KLLA0F15037g 1 1391311 1392204 ON 6 F15037 (1391311..1392204) weakly similar to uniprot|P29509 Saccharomyces cerevisiae YDR353W TRR1 Thioredoxin reductase Klac_6.trna13L 1 1392272 1392387 ON 6 tL-CAA (1392272..1392309,1392344..1392387) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.52 KLLA0F15103g 1 1393721 1394926 ON 6 F15103 (1393721..1394926) highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W RNR2 Ribonucleotide-diphosphate reductase (RNR) small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits KLLA0F15136g 1 1395315 1396466 ON 6 F15136 (1395315..1396466) some similarities with uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein required for accurate mitotic chromosome segregation forms a complex with Mcm21p and Okp1p that binds to centromeres via the CBF3 complex KLLA0F15158g 1 1397024 1399141 ON 6 F15158 (1397024..1399141) similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Protein interacting with poly(A)-binding protein Pab1p likely involved in control of the extent of mRNA polyadenylation KLLA0F15180g 1 1399547 1401121 ON 6 F15180 (1399547..1401121) similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 involved in the transcription of 35S rRNA genes by RNA polymerase I member of yeast Pol I core factor (CF) also composed of Rrn11p Rrn6p and TATA-binding protein KLLA0F15202g 1 1401627 1403180 ON 6 F15202 (1401627..1403180) similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase may play a role in steroid detoxification forms volatile esters during fermentation which is important in brewing KLLA0F15224g 1 1403958 1405460 ON 6 F15224 (1403958..1405460) highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase catalyzes the epoxidation of squalene to 2 3-oxidosqualene plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine KLLA0F15246g 1 1406040 1406471 ON 6 F15246 (1406040..1406471) similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Essential for the expression and activity of ubiquinol-cytochrome c reductase ubiquinol--cytochrome-c reductase assembly factor KLLA0F15268g 0 1406798 1407436 ON 6 F15268 complement(1406798..1407339,1407415..1407436) similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3 which is involved in vacuolar protein sorting related to the sigma subunit of the mammalian clathrin AP-3 complex suppressor of loss of casein kinase 1 function Klac_6.trna14G 0 1407817 1407887 ON 6 tG-GCC complement(1407817..1407887) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0F15312g 1 1408290 1408595 ON 6 F15312 (1408290..1408595) similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Translocase of the inner membrane mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins Subunit of mitochondrial protein import machinery KLLA0F15325g 0 1409287 1410061 ON 6 F15325 complement(1409287..1409493,1409993..1410061) similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex KLLA0F15334g 0 1410456 1416293 ON 6 F15334 complement(1410456..1416293) uniprot|O60014 Kluyveromyces lactis UBR1 N-END- RECOGNIZING PROTEIN (UBIQUITIN-PROTEIN LIGASE E3 COMPONENT) (N-RECOGNIN) KLLA0F15367g 1 1417215 1422344 ON 6 F15367 (1417215..1422344) similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3) KLLA0F15389g 0 1422689 1423882 ON 6 F15389 complement(1422689..1423882) highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 tyrosyl-tRNA synthetase cytoplasmic KLLA0F15411g 1 1424591 1426651 ON 6 F15411 (1424591..1426651) similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 Largest subunit of the RNA Polymerase general transcription factor IIF (TFIIF) interacts with Fcp1p phosphatase and with TFIIB potentially phosphorylated by Cdc28p KLLA0F15433g 0 1426837 1427997 ON 6 F15433 complement(1426837..1427997) similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C KLLA0F15455g 1 1428408 1428725 ON 6 F15455 (1428408..1428725) similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W Hypothetical ORF KLLA0F15477g 0 1429123 1431915 ON 6 F15477 complement(1429123..1431915) some similarities with uniprot|Q02601 Saccharomyces cerevisiae YLL013C PUF3 member of the PUF protein family which is named for the founding members PUmilio and Fbf KLLA0F15510g 1 1433494 1435362 ON 6 F15510 (1433494..1435362) some similarities with uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc metabolism member of the four-protein IZH family expression induced by zinc deficiency deletion reduces sensitivity to elevated zinc and shortens lag phase overexpression reduces Zap1p activity KLLA0F15532g 1 1436045 1436788 ON 6 F15532 (1436045..1436788) highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Protein required for cell viability KLLA0F15554g 0 1436864 1437343 ON 6 F15554 complement(1436864..1437343) similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W Hypothetical ORF KLLA0F15576g 1 1437595 1439133 ON 6 F15576 (1437595..1439133) similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C YEH2 Steryl ester hydrolase catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism KLLA0F15598g 1 1439610 1441046 ON 6 F15598 (1439610..1441046) highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W KLLA0F15620g 0 1441560 1442804 ON 6 F15620 complement(1441560..1442804) similar to uniprot|Q07800 Saccharomyces cerevisiae YLL010C KLLA0F15642g 1 1443555 1444742 ON 6 F15642 (1443555..1444742) weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 nuclear pore integral membrane protein KLLA0F15664g 0 1444888 1445904 ON 6 F15664 complement(1444888..1445904) highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP) catalyzes the initial step in the methionine salvage pathway affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity regulates ADH2 gene expression KLLA0F15686g 0 1446371 1447323 ON 6 F15686 complement(1446371..1446532,1447294..1447323) some similarities with uniprot|Q12287 Saccharomyces cerevisiae YLL009C COX17 Copper metallochaperone that shuttles copper from the cytosol to the mitochondrial intermembrane space for delivery to cytochrome c oxidase KLLA0F15708g 1 1447749 1453451 ON 6 F15708 (1447749..1453451) similar to uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase required for cAMP production and cAMP-dependent protein kinase signaling involved in cell cycle control and glucose and nitrogen repression of sporulation KLLA0F15730g 0 1453582 1454175 ON 6 F15730 complement(1453582..1454175) similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Multicopy suppressor of ypt6 null mutation KLLA0F15752g 1 1454735 1456981 ON 6 F15752 (1454735..1456981) similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function KLLA0F15774g 0 1457087 1459060 ON 6 F15774 complement(1457087..1459060) weakly similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Hypothetical ORF KLLA0F15796g 1 1459596 1460900 ON 6 F15796 (1459596..1460900) similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 Mitochondrial outer membrane protein required for normal mitochondrial morphology and mtDNA stability involved in tethering mitochondria to the actin cytoskeleton and in anchoring mtDNA nucleoids KLLA0F15807g 0 1460897 1463680 ON 6 F15807 complement(1460897..1463680) weakly similar to uniprot|Q07798 Saccharomyces cerevisiae YLL005C SPO75 Meiosis-specific protein of unknown function required for spore wall formation during sporulation dispensable for both nuclear divisions during meiosis KLLA0F15829g 0 1464112 1466337 ON 6 F15829 complement(1464112..1466337) similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C PMT2 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins acts in complex with Pmt1p dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase KLLA0F15862g 0 1466697 1467986 ON 6 F15862 complement(1466697..1467986) similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Nucleoside transporter with broad nucleoside selectivity localized to intracellular membranes KLLA0F15884g 0 1468612 1470984 ON 6 F15884 complement(1468612..1470984) similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex which is involved in regulation of gene expression component of the major cytoplasmic deadenylase which is involved in mRNA poly(A) tail shortening KLLA0F15906g 0 1472413 1473462 ON 6 F15906 complement(1472413..1473462) similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein with a potential role in regulatory interactions between microtubules and the cell cycle as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1 KLLA0F15928g 1 1475341 1476714 ON 6 F15928 (1475341..1476714) similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C MTH1 Negative regulator of the glucose-sensing signal transduction pathway required for repression of transcription by Rgt1p interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors phosphorylated by Yck1p triggering Mth1p degradation KLLA0F15950g 1 1477113 1478522 ON 6 F15950 (1477113..1478522) similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus Klac_YGOB_Anc_5.642 1 1478891 1479301 ON 6 Anc_5.642 (1478891..1478924,1479168..1479301) ANNOTATED BY YGOB - KLLA0F15961g 0 1479993 1480163 ON 6 F15961 complement(1479993..1480163) similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components Klac_YGOB_Anc_5.640 0 1480701 1480952 ON 6 Anc_5.640 complement(1480701..1480952) ANNOTATED BY YGOB - Search-DOGS addition KLLA0F15972g 0 1481761 1483137 ON 6 F15972 complement(1481761..1483137) similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required with binding partner Psr1p for full activation of the general stress response possibly through Msn2p dephosphorylation regulates growth during the diauxic shift negative regulator of G1 cyclin expression KLLA0F15994g 0 1484383 1485666 ON 6 F15994 complement(1484383..1485666) similar to uniprot|Q08412 Saccharomyces cerevisiae YOR042W CUE5 Protein containing a CUE domain that binds ubiquitin which may facilitate intramolecular monoubiquitination green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern KLLA0F16016g 0 1486406 1487257 ON 6 F16016 complement(1486406..1487257) similar to uniprot|Q12320 Saccharomyces cerevisiae YOR040W GLO4 Mitochondrial glyoxalase II catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate KLLA0F16038g 0 1487475 1490063 ON 6 F16038 complement(1487475..1490063) conserved hypothetical protein KLLA0F16060g 1 1490815 1491960 ON 6 F16060 (1490815..1491960) similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Hypothetical ORF KLLA0F16082g 0 1492435 1493547 ON 6 F16082 complement(1492435..1493547) similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane KLLA0F16104g 1 1495067 1497241 ON 6 F16104 (1495067..1497241) similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate acyltransferase located in both lipid particles and the ER involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone which are intermediate steps in lipid biosynthesis KLLA0F16126g 0 1497393 1498019 ON 6 F16126 complement(1497393..1498019) highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles component of the TRAPP (transport protein particle) complex KLLA0F16148g 0 1498362 1499645 ON 6 F16148 complement(1498362..1499645) similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0F16170g 1 1500288 1502078 ON 6 F16170 (1500288..1502078) similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase KLLA0F16192g 1 1502331 1503398 ON 6 F16192 (1502331..1503398) similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Hypothetical ORF KLLA0F16214g 0 1503855 1504211 ON 6 F16214 complement(1503855..1504211) some similarities with uniprot|O00017 Saccharomyces cerevisiae YOR052C KLLA0F16236g 0 1504621 1505652 ON 6 F16236 complement(1504621..1505652) similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2 KLLA0F16258g 0 1506192 1508141 ON 6 F16258 complement(1506192..1508141) weakly similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C VHS3 Regulatory subunit of Ppz1p which is an isoform of serine/threonine protein phosphatase Z involved in regulation of potassium transport overexpression suppresses the synthetic lethality of the hal3 sit4 double mutation KLLA0F16280g 0 1508963 1510381 ON 6 F16280 complement(1508963..1510381) similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Nin1 (One) Binding protein essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosome subunits required for cleavage of the 20S pre- rRNA to generate the mature 18S rRNA. KLLA0F16302g 1 1510954 1512093 ON 6 F16302 (1510954..1512093) similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Probable cochaperone regulates activity of Cyr1p (adenylyl cyclase) involved in assembly of the kinetochore complex associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex KLLA0F16324g 0 1512218 1514623 ON 6 F16324 complement(1512218..1514623) weakly similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Member of a family of microtubule- associated proteins (MAPs) that function at the mitotic spindle midzone required for spindle elongation undergoes cell cycle-regulated degradation by anaphase promoting complex potential Cdc28p substrate Klac_6.trna15K 1 1515694 1515783 ON 6 tK-UUU (1515694..1515730,1515748..1515783) tRNA Type: Lys (K) | Anti-Codon: UUU | Cove Score: 68.45 KLLA0F16401g 1 1516101 1516544 ON 6 F16401 (1516101..1516544) highly similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W Hypothetical ORF KLLA0F16423g 0 1516717 1518096 ON 6 F16423 complement(1516717..1518096) similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF KLLA0F16445g 0 1518557 1519339 ON 6 F16445 complement(1518557..1519339) similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C Protein required for cell viability KLLA0F16467g 1 1519800 1520822 ON 6 F16467 (1519800..1520822) highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 alpha' subunit of casein kinase II KLLA0F16489g 0 1521430 1522218 ON 6 F16489 complement(1521430..1522218) some similarities with uniprot|P36155 Saccharomyces cerevisiae or YOR062c uniprot|P36025 Saccharomyces cerevisiae KLLA0F16511g 1 1523895 1525058 ON 6 F16511 (1523895..1525058) highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W KLLA0F16533g 0 1525315 1525986 ON 6 F16533 complement(1525315..1525986) weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Yeast homolog of mammalian Ing1 histone acetyltransferase complex component KLLA0F16555g 1 1526892 1527770 ON 6 F16555 (1526892..1527770) uniprot|Q00988 Kluyveromyces lactis KLLA0F16555g CYT1 Cytochrome c1, heme protein, mitochondrial precursor KLLA0F16577g 0 1529359 1529706 ON 6 F16577 complement(1529359..1529706) no similarity KLLA0F16599g 1 1529975 1531561 ON 6 F16599 (1529975..1531561) weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W Protein of unknown function potential Cdc28p substrate KLLA0F16621g 0 1531745 1533430 ON 6 F16621 complement(1531745..1533430) highly similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 adds glucose to the dolichol- linked oligosaccharide precursor prior to transfer to protein glycosyl transferase KLLA0F16643g 1 1533628 1535625 ON 6 F16643 (1533628..1535625) similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W VPS5 Component of the retromer coat that retrieves proteins from late endosomes sorting nexin I homolog KLLA0F16665g 0 1535656 1538124 ON 6 F16665 complement(1535656..1538124) similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 Protein required for cell viability Klac_6.trna16G 1 1538923 1538993 ON 6 tG-CCC (1538923..1538993) tRNA Type: Gly (G) | Anti-Codon: CCC | Cove Score: 64.77 KLLA0F16709g 1 1539612 1541207 ON 6 F16709 (1539612..1541207) some similarities with uniprot|O00022 Saccharomyces cerevisiae YOR059C Hypothetical ORF KLLA0F16731g 0 1541253 1541663 ON 6 F16731 complement(1541253..1541663) weakly similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C Hypothetical ORF KLLA0F16753g 0 1541959 1543422 ON 6 F16753 complement(1541959..1543422) similar to uniprot|P21375 Saccharomyces cerevisiae YJR051W OSM1 Fumarate reductase catalyzes the reduction of fumarate to succinate required for the reoxidation of intracellular NADH under anaerobic conditions mutations cause osmotic sensitivity KLLA0F16775g 0 1544839 1546026 ON 6 F16775 complement(1544839..1546026) highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase catalyzes the cleavage of L-allo-threonine and L-threonine to glycine involved in glycine biosynthesis KLLA0F16797g 1 1547190 1547609 ON 6 F16797 (1547190..1547609) similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions KLLA0F16819g 1 1548402 1550327 ON 6 F16819 (1548402..1550327) uniprot|Q96WJ2 Kluyveromyces lactis PRM1 Paromomycin- resistance protein Prm1 KLLA0F16841g 0 1550523 1551236 ON 6 F16841 complement(1550523..1551236) similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Component of the spliceosome complex involved in pre-mRNA splicing auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing isy1 syf2 double mutation activates the spindle checkpoint causing cell cycle arrest KLLA0F16863g 1 1551578 1553146 ON 6 F16863 (1551578..1553146) uniprot|Q9HEM6 Kluyveromyces lactis KLLA0F16863g GDA1 Guanosine-diphosphatase KLLA0F16885g 1 1553518 1555107 ON 6 F16885 (1553518..1555107) highly similar to uniprot|P21373 Saccharomyces cerevisiae YJR049C UTR1 NAD kinase active as a hexamer enhances the activity of ferric reductase (Fre1p) KLLA0F16907g 1 1555857 1557215 ON 6 F16907 (1555857..1557215) similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Putative glycosidase glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck has a role in cell wall maintenance KLLA0F16929g 0 1558278 1558610 ON 6 F16929 complement(1558278..1558610) uniprot|P32556 Kluyveromyces lactis KLLA0F16929g CYCK Cytochrome c KLLA0F16962g 0 1559454 1561190 ON 6 F16962 complement(1559454..1561190) uniprot|O74722 Kluyveromyces lactis PDC Pyruvate decarboxylase KLLA0F17006g 0 1561859 1563106 ON 6 F17006 complement(1561859..1563106) uniprot|O60042 Kluyveromyces lactis GSK-3 Protein kinase KLLA0F17028g 0 1563907 1564425 ON 6 F17028 complement(1563907..1564425) no similarity KLLA0F17050g 0 1564921 1565937 ON 6 F17050 complement(1564921..1565937) similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Cytoplasmic malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the glyoxylate cycle KLLA0F17072g 0 1566668 1567240 ON 6 F17072 complement(1566668..1567240) similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding KLLA0F17094g 1 1567507 1569048 ON 6 F17094 (1567507..1569048) similar to uniprot|Q759M6 Ashbya gossypii ADR250C ADR250Cp and weakly similar to YMR137C uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Required for a post- incision step in the repair of DNA single and double- strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives induced by UV-irradiation KLLA0F17116g 0 1569192 1570367 ON 6 F17116 complement(1569192..1570367) weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 KLLA0F17138g 1 1571290 1572351 ON 6 F17138 (1571290..1572351) similar to uniprot|Q759M8 Ashbya gossypii ADR248C ADR248Cp and weakly similar to YMR135C uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function involved in proteasome-dependent catabolite inactivation of fructose-1 6-bisphosphatase contains LisH and CTLH domains like Vid30p KLLA0F17160g 0 1572441 1573163 ON 6 F17160 complement(1572441..1573163) similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein required for cell viability KLLA0F17182g 1 1574167 1574808 ON 6 F17182 (1574167..1574808) some similarities with uniprot|Q07988 Saccharomyces cerevisiae YLR040C Hypothetical ORF KLLA0F17198g 0 1574538 1575825 ON 6 F17198 complement(1574538..1574726,1574995..1575825) weakly similar to uniprot|P32841 Saccharomyces cerevisiae YMR133W REC114 Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division KLLA0F17215g 1 1576281 1576910 ON 6 F17215 (1576281..1576910) similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Hypothetical ORF KLLA0F17237g 1 1577197 1578768 ON 6 F17237 (1577197..1578768) highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 essential nuclear protein involved in early steps of ribosome biogenesis KLLA0F17259g 1 1579097 1582111 ON 6 F17259 (1579097..1582111) similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p involved in transcription of ribosomal protein genes and ribosomal RNA KLLA0F17281g 1 1582850 1583098 ON 6 F17281 (1582850..1583098) highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain required for assembly of fully active cytochrome c oxidase but not required for activity after assembly Klac_6.trna17A 1 1583941 1584013 ON 6 tA-UGC (1583941..1584013) tRNA Type: Ala (A) | Anti-Codon: UGC | Cove Score: 76.57 KLLA0F17325g 0 1584146 1585069 ON 6 F17325 complement(1584146..1585069) similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Hypothetical ORF KLLA0F17347g 1 1585317 1587149 ON 6 F17347 (1585317..1587149) some similarities with uniprot|Q07980 Saccharomyces cerevisiae YLR035C MLH2 Protein required for DNA mismatch repair in mitosis and meiosis KLLA0F17369g 0 1587214 1591122 ON 6 F17369 complement(1587214..1591122) similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase KLLA0F17391g 1 1592278 1593708 ON 6 F17391 (1592278..1593708) highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative metal transporter Nramp homolog homolog of SMF1 and SMF2 KLLA0F17413g 0 1594037 1595764 ON 6 F17413 complement(1594037..1595489,1595709..1595764) similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Remodels the structure of chromatin complex 58KDa subunit; Chromatin Remodeling Complex subunit KLLA0F17435g 0 1596081 1599896 ON 6 F17435 complement(1596081..1599896) similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP predominantly nucleolar in distribution required for 18S rRNA synthesis KLLA0F17457g 1 1600261 1601220 ON 6 F17457 (1600261..1601220) similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p) which acetylates free histones and nucleosomes and regulates transcriptional silencing member of the MYSTacetyltransferase family KLLA0F17479g 0 1601287 1604631 ON 6 F17479 complement(1601287..1604631) similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 Single-stranded DNA-dependent ATPase involved in postreplication repair KLLA0F17501g 1 1605244 1606224 ON 6 F17501 (1605244..1606224) similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function deletion causes sensitivity to thermal stress KLLA0F17523g 0 1606456 1609023 ON 6 F17523 complement(1606456..1609023) similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex interacts with Npl3p to carry poly(A) mRNA from the nucleus to the cytoplasm also involved in mRNA degradation in the nucleus orthologous to mammalian CBP80 KLLA0F17545g 0 1609839 1612619 ON 6 F17545 complement(1609839..1612619) weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery cytoplasm bud and bud neck KLLA0F17567g 0 1613341 1613721 ON 6 F17567 complement(1613341..1613721) similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 Protein of unknown function overproduction confers resistance to Pichia farinosa killer toxin KLLA0F17589g 0 1614223 1614759 ON 6 F17589 complement(1614223..1614759) some similarities with uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A KLLA0F17611g 0 1616198 1616629 ON 6 F17611 complement(1616198..1616629) no similarity KLLA0F17633g 1 1618128 1618742 ON 6 F17633 (1618128..1618742) highly similar to uniprot|P54780 Saccharomyces cerevisiae RPL15B and to uniprot|P05748 Saccharomyces cerevisiae YLR029C RPL15A KLLA0F17655g 1 1619715 1621487 ON 6 F17655 (1619715..1621487) highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4- carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities isozyme of Ade16p ade16 ade17 mutants require adenine and histidine Klac_YGOB_snR30 0 1621811 1622323 ON 6 snR30 complement(1621811..1622323) ANNOTATED BY YGOB - KLLA0F17677g 0 1622629 1624656 ON 6 F17677 complement(1622629..1624656) similar to uniprot|P54074 Saccharomyces cerevisiae YMR119W ASI1 Putative integral membrane E3 ubiquitin ligase genetic interactions suggest a role in negative regulation of amino acid uptake Klac_6.trna18L 0 1625164 1625279 ON 6 tL-CAA complement(1625164..1625207,1625242..1625279) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.66 KLLA0F17754g 1 1625775 1627040 ON 6 F17754 (1625775..1627040) highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase involved in nitrogen metabolism localizes to peroxisomes in oleate-grown cells KLLA0F17776g 0 1627198 1628859 ON 6 F17776 complement(1627198..1628859) weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane KLLA0F17798g 1 1629735 1630688 ON 6 F17798 (1629735..1630688) similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport KLLA0F17820g 0 1630888 1631586 ON 6 F17820 complement(1630888..1631586) weakly similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 Involved in derepression of SUC2 in response to glucose limitation involved in glucose derepression KLLA0F17842g 1 1633022 1633354 ON 6 F17842 (1633022..1633354) conserved hypothetical protein KLLA0F17864g 0 1634241 1635164 ON 6 F17864 complement(1634241..1635164) similar to uniprot|P32331 Saccharomyces cerevisiae YPR058W YMC1 Putative mitochondrial inner membrane transporter member of the mitochondrial carrier (MCF) family KLLA0F17886g 0 1636432 1637484 ON 6 F17886 complement(1636432..1637484) similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C KLLA0F17908g 1 1637803 1638489 ON 6 F17908 (1637803..1638489) similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C KLLA0F17930g 1 1638931 1643925 ON 6 F17930 (1638931..1643925) similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1 KLLA0F17952g 0 1643977 1644645 ON 6 F17952 complement(1643977..1644645) similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family methylates release factor eRF1 (Sup45p) in vitro KLLA0F17974g 1 1644903 1645237 ON 6 F17974 (1644903..1645051,1645153..1645237) similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8 KLLA0F17996g 1 1645592 1647646 ON 6 F17996 (1645592..1647646) similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 essential splicesome assembly factor KLLA0F18018g 0 1647748 1649127 ON 6 F18018 complement(1647748..1649127) some similarities with uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex which defines the first step in the splicing pathway essential protein that interacts with Mud2p and Prp40p forming a bridge between the intron ends also involved in nuclear retention of pre-mRNA KLLA0F18040g 0 1649483 1650629 ON 6 F18040 complement(1649483..1649917,1650609..1650629) highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins KLLA0F18062g 0 1651147 1651590 ON 6 F18062 complement(1651147..1651590) similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W Hypothetical ORF KLLA0F18084g 0 1652031 1654613 ON 6 F18084 complement(1652031..1654613) conserved hypothetical protein KLLA0F18106g 1 1657556 1659325 ON 6 F18106 (1657556..1659325) similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Proton-motive-force-dependent multidrug transporter of the major facilitator superfamily able to transport eight different compounds including polyamines quinidine cycloheximide and nystatin involved in excess spermidine detoxification KLLA0F18128g 1 1661367 1663535 ON 6 F18128 (1661367..1663535) similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W Hypothetical ORF KLLA0F18150g 1 1664428 1665123 ON 6 F18150 (1664428..1665123) some similarities with uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency depletion reduces growth on nonfermentable carbon sources KLLA0F18194g 1 1668282 1670981 ON 6 F18194 (1668282..1670981) highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured aggregated proteins responsive to stresses including: heat ethanol and sodium arsenite involved in [PSI ] propagation KLLA0F18216g 1 1677731 1679857 ON 6 F18216 (1677731..1679857) some similarities with uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes KLLA0F18238g 0 1680299 1682833 ON 6 F18238 complement(1680299..1682833) some similarities with uniprot|P38742 Saccharomyces cerevisiae YHL023C RMD11 Protein required for sporulation KLLA0F18260g 0 1683417 1684463 ON 6 F18260 complement(1683417..1684463) uniprot|P49383 Kluyveromyces lactis KLLA0F18260g ADH2 Alcohol dehydrogenase 2 KLLA0F18282g 1 1686456 1689005 ON 6 F18282 (1686456..1689005) similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 First step in the methylation pathway for phosphatidylcholine biosynthesis Phosphatidyl-ethanolamine N-methyltransferase KLLA0F18304g 0 1689187 1689897 ON 6 F18304 complement(1689187..1689897) similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 3'5' exoribonuclease exosome subunit nucleolar protein involved in export of mRNA and ribosomal subunits homologous to the E. coli exonuclease RNase PH Klac_6.trna19T 0 1691317 1691389 ON 6 tT-AGU complement(1691317..1691389) tRNA Type: Thr (T) | Anti-Codon: AGU | Cove Score: 71.56 KLLA0F18370g 1 1692172 1692711 ON 6 F18370 (1692172..1692711) conserved hypothetical protein KLLA0F18392g 1 1693928 1695694 ON 6 F18392 (1693928..1695694) highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase also identified as a negative regulator of general control of amino acid biosynthesis KLLA0F18414g 0 1695869 1696774 ON 6 F18414 complement(1695869..1696774) similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop KLLA0F18436g 1 1697109 1697732 ON 6 F18436 (1697109..1697732) similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins KLLA0F18458g 0 1697871 1698293 ON 6 F18458 complement(1697871..1698293) similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Hypothetical ORF KLLA0F18480g 0 1698689 1699180 ON 6 F18480 complement(1698689..1699180) no similarity KLLA0F18502g 0 1699447 1700355 ON 6 F18502 complement(1699447..1700355) weakly similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome function may be regulated by Slu7p KLLA0F18524g 0 1701498 1702571 ON 6 F18524 complement(1701498..1702571) some similarities with uniprot|Q03125 Saccharomyces cerevisiae YDR043C NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters KLLA0F18546g 1 1706744 1707871 ON 6 F18546 (1706744..1707871) uniprot|Q70W35 Kluyveromyces lactis putative coproporphyrinogen oxidase KLLA0F18568g 0 1708319 1708657 ON 6 F18568 complement(1708319..1708657) highly similar to uniprot|Q04307 YDR045C Saccharomyces cerevisiae RPC11 RNA polymerase III subunit C11 KLLA0F18590g 1 1709034 1710824 ON 6 F18590 (1709034..1710824) similar to uniprot|P32833 YBR060C Saccharomyces cerevisiae ORC2 Subunit of the origin recognition complex KLLA0F18612g 1 1711131 1713575 ON 6 F18612 (1711131..1713575) some similarities with uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Serine-threonine protein kinase member (with Ark1p and Prk1p) of the Ark kinase family KLLA0F18634g 1 1713947 1714201 ON 6 F18634 (1713947..1714201) similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p,Lcb2p) several-fold; involved in sphingolipid biosynthesis KLLA0F18656g 0 1714588 1715742 ON 6 F18656 complement(1714588..1715742) conserved hypothetical protein KLLA0F18678g 1 1716890 1718404 ON 6 F18678 (1716890..1718404) similar to uniprot|P28817 YDR036C Saccharomyces cerevisiae EHD3 Protein of unconfirmed function plays an indirect role in endocytic membrane trafficking member of a family of enoyl-CoA hydratase/isomerases KLLA0F18700g 1 1718738 1721050 ON 6 F18700 (1718738..1721050) similar to uniprot|P38237 YBR058C Saccharomyces cerevisiae UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains KLLA0F18722g 1 1721734 1722546 ON 6 F18722 (1721734..1722546) some similarities with uniprot|P38236 YBR057C Saccharomyces cerevisiae MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation KLLA0F18744g 0 1723008 1724126 ON 6 F18744 complement(1723008..1724126) highly similar to uniprot|P14843 YDR035W Saccharomyces cerevisiae ARO3 3-deoxy-D-arabino- heptulosonate-7- phosphate (DAHP) synthase KLLA0F18766g 0 1725142 1725348 ON 6 F18766 complement(1725142..1725348) similar to uniprot|Q6Q5X2 Saccharomyces cerevisiae YDR034W-B Protein of unknown function; green fluorescent protein (GFP)-fusion protein KLLA0F18788g 0 1726046 1727515 ON 6 F18788 complement(1726046..1727515) similar to uniprot|P38081 YBR056W Saccharomyces cerevisiae Hypothetical ORF KLLA0F18810g 1 1728000 1728941 ON 6 F18810 (1728000..1728941) similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C Hypothetical ORF KLLA0F18832g 1 1729736 1730482 ON 6 F18832 (1729736..1730482) highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 induced under stress conditions triosephosphate isomerase KLLA0F18865g 0 1730609 1731319 ON 6 F18865 complement(1730609..1731319) similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Essential protein required for the second step of dolichyl-linked oligosaccharide synthesis; involved in N-linked glycosylation; similar to bacterial glycosyltransferases KLLA0F18887g 1 1732170 1732529 ON 6 F18887 (1732170..1732529) conserved hypothetical protein KLLA0F18909g 1 1733468 1734058 ON 6 F18909 (1733468..1734058) similar to uniprot|P15992 Saccharomyces cerevisiae YBR072W HSP26 Small heat shock protein with chaperone activity that is regulated by a heat induced transition from an inactive oligomeric (24-mer) complex to an active dimer induced by heat upon entry into stationary phase and during sporulation KLLA0F18931g 0 1734636 1736633 ON 6 F18931 complement(1734636..1736633) similar to uniprot|P32802 Saccharomyces cerevisiae YLR083C EMP70 Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions predicted to be a transmembrane protein KLLA0F18953g 1 1737522 1739465 ON 6 F18953 (1737522..1739465) similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W GSG1 Subunit of TRAPP (transport protein particle) a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment protein has late meiotic role following DNA replication KLLA0F18975g 0 1739543 1743145 ON 6 F18975 complement(1739543..1743145) similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding localization requires Rax1p KLLA0F18997g 0 1747295 1748497 ON 6 F18997 complement(1747295..1748497) some similarities with uniprot|Q74ZV5 Ashbya gossypii AGR094W AGR094Wp KLLA0F19041g 0 1753543 1755834 ON 6 F19041 complement(1753543..1755834) similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Hypothetical ORF KLLA0F19063g 0 1756529 1757776 ON 6 F19063 complement(1756529..1757776) similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Nuclear actin-related protein involved in chromatin remodeling component of chromatin-remodeling enzyme complexes KLLA0F19085g 1 1758111 1762229 ON 6 F19085 (1758111..1762229) similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 subunit of the condensin complex which reorganizes chromosomes during cell division KLLA0F19096g 0 1762215 1770986 ON 6 F19096 complement(1762215..1770986) similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature KLLA0F19118g 1 1771250 1772986 ON 6 F19118 (1771250..1772986) similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI:protein transamidase complex removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER KLLA0F19140g 1 1773327 1774910 ON 6 F19140 (1773327..1774910) some similarities with uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities binds to the replication fork barrier site in the rDNA region related to retroviral integrases KLLA0F19162g 0 1775240 1776826 ON 6 F19162 complement(1775240..1776826) similar to uniprot|P52893 Saccharomyces cerevisiae YLR089C ALT1 putative alanine transaminase (glutamyc pyruvic transaminase) KLLA0F19184g 1 1778227 1779765 ON 6 F19184 (1778227..1779765) similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative homolog of E. coli DnaJ closely related to Ydj1p KLLA0F19206g 0 1780093 1780884 ON 6 F19206 complement(1780093..1780884) weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin that inhibits anaphase by binding separin Esp1p also blocks cyclin destruction and mitotic exit essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles also present in meiotic nuclei KLLA0F19228g 1 1781494 1782411 ON 6 F19228 (1781494..1782411) conserved hypothetical protein KLLA0F19250g 1 1782824 1783174 ON 6 F19250 (1782824..1783174) similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W KLLA0F19272g 0 1783497 1784297 ON 6 F19272 complement(1783497..1784297) similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit KLLA0F19294g 0 1784664 1786376 ON 6 F19294 complement(1784664..1786376) similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C RBF64 Hypothetical ORF KLLA0F19316g 1 1786659 1788674 ON 6 F19316 (1786659..1788674) conserved hypothetical protein KLLA0F19338g 1 1789536 1792211 ON 6 F19338 (1789536..1792211) similar to uniprot|P38359 Saccharomyces cerevisiae YBR294W SUL1 High affinity sulfate permease sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p which control the concentration of endogenous activated sulfate intermediates and uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 KLLA0F19360g 1 1792778 1793812 ON 6 F19360 (1792778..1793812) highly similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance KLLA0F19371g 1 1794714 1794956 ON 6 F19371 (1794714..1794956) some similarities with uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Pi KLLA0F19382g 1 1795951 1796178 ON 6 F19382 (1795951..1796178) some similarities with uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Pi KLLA0F19404g 0 1796569 1798242 ON 6 F19404 complement(1796569..1798242) similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase localizes to both the nucleus and mitochondrion to produce the modified base N2 N2-dimethylguanosine in tRNAs in both compartments KLLA0F19426g 1 1798814 1799464 ON 6 F19426 (1798814..1799464) similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex involved in both chromosomal DNA replication and in inheritance of telomeric silencing KLLA0F19448g 0 1799571 1800266 ON 6 F19448 complement(1799571..1800266) similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion inhibits ATP-dependent Ca(2 ) transport activity of Pmc1p in the vacuolar membrane KLLA0F19470g 0 1800700 1802205 ON 6 F19470 complement(1800700..1802205) similar to uniprot|Q750A2 Ashbya gossypii AGR055C AGR055Cp and some similarities with YHR176W uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase localized to the cytoplasmic face of the ER membrane catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins KLLA0F19492g 0 1803008 1804366 ON 6 F19492 complement(1803008..1804366) some similarities with uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function KLLA0F19514g 0 1804838 1807057 ON 6 F19514 complement(1804838..1807057) similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p KLLA0F19536g 1 1808263 1811577 ON 6 F19536 (1808263..1811577) similar to uniprot|P13186 Saccharomyces cerevisiae YLR096W KIN2 Serine/threonine protein kinase involved in regulation of exocytosis localizes to the cytoplasmic face of the plasma membrane closely related to Kin1p and to YDR122W uniprot|P13185 Saccharomyces cerevisiae YDR122W KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p KLLA0F19558g 0 1811729 1812886 ON 6 F19558 complement(1811729..1812886) weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs) required for derepression of phospholipid biosynthetic genes in response to inositol depletion KLLA0F19580g 0 1813462 1814511 ON 6 F19580 complement(1813462..1814511) similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative nuclear ubiquitin ligase based on computational analysis of large-scale protein-protein interaction data KLLA0F19602g 0 1814949 1816760 ON 6 F19602 complement(1814949..1816760) similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 Zinc-finger protein with Zn[2]-Cys[6] fungal- type binuclear cluster domain DNA-binding transcriptional activator or CHA1 and some similarities to YOR337W uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Mutants are defective in Ty1 Enhancer-mediated Activation Ty1 enhancer activator KLLA0F19624g 0 1817206 1818435 ON 6 F19624 complement(1817206..1818435) similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C ECM18 Protein of unknown function, similar to Rlp24p KLLA0F19646g 1 1818898 1819257 ON 6 F19646 (1818898..1819257) some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Hypothetical ORF KLLA0F19668g 0 1819417 1819905 ON 6 F19668 complement(1819417..1819905) conserved hypothetical protein KLLA0F19690g 1 1820355 1821329 ON 6 F19690 (1820355..1821329) similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Spore Wall Formation KLLA0F19712g 1 1821832 1826568 ON 6 F19712 (1821832..1826568) highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein catalyzes steps 2 through 6 in the biosynthesis of chorismate which is a precursor to aromatic amino acids KLLA0F19734g 1 1826828 1830229 ON 6 F19734 (1826828..1830229) similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W Hypothetical ORF KLLA0F19756g 1 1830489 1831529 ON 6 F19756 (1830489..1831529) highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis mutants are sterol auxotrophs KLLA0F19778g 0 1831727 1833700 ON 6 F19778 complement(1831727..1833700) highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton KLLA0F19800g 0 1834144 1834698 ON 6 F19800 complement(1834144..1834698) no similarity KLLA0F19822g 0 1835015 1837009 ON 6 F19822 complement(1835015..1837009) similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor KLLA0F19844g 1 1837295 1837699 ON 6 F19844 (1837295..1837699) similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W Hypothetical ORF KLLA0F19866g 0 1837874 1838983 ON 6 F19866 complement(1837874..1838983) similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C KLLA0F19888g 0 1839682 1854429 ON 6 F19888 complement(1839682..1854429) similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin) forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p) may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm KLLA0F19910g 1 1854593 1856029 ON 6 F19910 (1854593..1856029) similar to uniprot|Q12090 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease required for maturation of the RNA component of RNase MRP KLLA0F19921g 0 1856021 1856719 ON 6 F19921 complement(1856021..1856719) some similarities with uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Basic protein with putative coiled- coil regions that comprises a filament between spindle pole bodies KLLA0F19943g 0 1856924 1858504 ON 6 F19943 complement(1856924..1858504) weakly similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C Hypothetical ORF KLLA0F19965g 0 1859394 1860752 ON 6 F19965 complement(1859394..1860752) similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C Hypothetical ORF KLLA0F20009g 1 1862310 1862825 ON 6 F20009 (1862310..1862825) similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin reduces hydroperoxides to protect against oxidative damage function in vivo requires covalent conjugation to Urm1p KLLA0F20031g 0 1863884 1864258 ON 6 F20031 complement(1863884..1864258) some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C CCW12 Cell wall protein KLLA0F20053g 1 1867209 1868543 ON 6 F20053 (1867209..1868543) highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation KLLA0F20075g 0 1868786 1873336 ON 6 F20075 complement(1868786..1873336) similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C Klac_6.trna20V 1 1873730 1873803 ON 6 tV-AAC (1873730..1873803) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 KLLA0F20119g 1 1874062 1877319 ON 6 F20119 (1874062..1877319) similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Protein required for accurate sister chromatid segregation KLLA0F20141g 0 1877664 1878839 ON 6 F20141 complement(1877664..1878839) highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase a mitochondrial inner membrane protein catalyzes the insertion of ferrous iron into protoporphyrin IX the eighth and final step in the heme biosynthetic pathway Yfh1p mediates the use of iron by Hem15p KLLA0F20163g 1 1880075 1881922 ON 6 F20163 (1880075..1881922) similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C Hypothetical ORF KLLA0F20185g 0 1882094 1882951 ON 6 F20185 complement(1882094..1882951) similar to uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Member of RNA Polymerase II transcriptional regulation mediator Stoichiometric member of mediator complex KLLA0F20207g 0 1883230 1884093 ON 6 F20207 complement(1883230..1884093) weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Hypothetical ORF KLLA0F20229g 0 1884343 1885395 ON 6 F20229 complement(1884343..1885395) highly similar to uniprot|Q6Q5L1 Saccharomyces cerevisiae YLR270W DCS1 Non-essential hydrolase involved in mRNA decapping may function in a feedback mechanism to regulate deadenylation contains pyrophosphatase activity and a HIT (histidine triad) motif interacts with neutral trehalase Nth1p KLLA0F20251g 0 1885728 1886372 ON 6 F20251 complement(1885728..1886372) similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein assembles into SNARE complex with Bet1p Bos1p and Sed5p cycles between the ER and Golgi complex involved in anterograde and retrograde transport between the ER and Golgi synaptobrevin homolog KLLA0F20273g 1 1886914 1887453 ON 6 F20273 (1886914..1887453) similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Diadenosine polyphosphate hydrolase member of the MutT family of nucleotide hydrolases with high specificity for diadenosine hexa- and pentaphosphates required for efficient hydrolysis of diphosphorylated inositol polyphosphates KLLA0F20295g 0 1887496 1888404 ON 6 F20295 complement(1887496..1888404) similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C Hypothetical ORF KLLA0F20317g 1 1888803 1891163 ON 6 F20317 (1888803..1891163) similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 Synthetic Enhancement with YOP1 KLLA0F20339g 1 1891435 1892337 ON 6 F20339 (1891435..1892337) no similarity KLLA0F20361g 0 1892426 1893769 ON 6 F20361 complement(1892426..1893769) some similarities with uniprot|Q12104 Saccharomyces cerevisiae YOR166C Hypothetical ORF KLLA0F20383g 0 1894577 1894780 ON 6 F20383 complement(1894577..1894780) highly similar to uniprot|P02380 Saccharomyces cerevisiae YOR167C RPS28A and highly similar to uniprot|P02380 Saccharomyces cerevisiae YLR264W RPS28B Protein component of the small (40S) ribosomal subunit KLLA0F20405g 0 1895179 1897830 ON 6 F20405 complement(1895179..1897473,1897564..1897830) uniprot|Q9MEM7 Kluyveromyces lactis RED1 protein KLLA0F20449g 1 1898253 1900667 ON 6 F20449 (1898253..1900667) highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu) N-terminal domain proposed to be involved in enzyme-tRNA interactions KLLA0F20460g 1 1900998 1901189 ON 6 F20460 (1900998..1901189) highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A RBF7 Similar to C. elegans protein KLLA0F20471g 1 1901749 1902387 ON 6 F20471 (1901749..1902387) highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi; has similarity to the human GTPase, Rab6 KLLA0F20504g 0 1902726 1904429 ON 6 F20504 complement(1902726..1904429) similar to uniprot|Q12246 Saccharomyces cerevisiae YLR260W LCB5 Minor sphingoid long-chain base kinase paralog of Lcb4p responsible for few percent of the total activity possibly involved in synthesis of long-chain base phosphates which function as signaling molecules and similar to YOR171c KLLA0F20526g 1 1905477 1906721 ON 6 F20526 (1905477..1906721) weakly similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Pta1p Interacting protein KLLA0F20548g 1 1907637 1909055 ON 6 F20548 (1907637..1909055) highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways required for normal oxidative stress tolerance and nitrogen utilization KLLA0F20570g 1 1909451 1909990 ON 6 F20570 (1909451..1909990) similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Hypothetical ORF Klac_6.trna21H 0 1910096 1910167 ON 6 tH-GUG complement(1910096..1910167) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 68.23 KLLA0F20603g 1 1910783 1910962 ON 6 F20603 (1910783..1910962) no similarity KLLA0F20614g 1 1913174 1913569 ON 6 F20614 (1913174..1913569) no similarity KLLA0F20636g 0 1914452 1915309 ON 6 F20636 complement(1914452..1915309) some similarities with uniprot|Q12531 Saccharomyces cerevisiae YPR015c KLLA0F20658g 1 1919851 1923099 ON 6 F20658 (1919851..1923099) similar to uniprot|Q12691 Saccharomyces cerevisiae YDR038C ENA5 Protein with similarity to P-type ATPase sodium pumps KLLA0F20680g 1 1924148 1926511 ON 6 F20680 (1924148..1926511) weakly similar to uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription Ume6p is a C6 zinc finger URS1-binding protein. KLLA0F20702g 0 1927059 1929767 ON 6 F20702 complement(1927059..1929767) uniprot|Q9C403 Kluyveromyces lactis Putative EBS1- like protein KLLA0F20724g 1 1931937 1933916 ON 6 F20724 (1931937..1933916) similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III KLLA0F20746g 0 1934089 1936200 ON 6 F20746 complement(1934089..1936200) weakly similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family localizes to the endoplasmic reticulum and nucleus mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids KLLA0F20768g 0 1936804 1937520 ON 6 F20768 complement(1936804..1937520) similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C KLLA0F20790g 0 1937781 1938836 ON 6 F20790 complement(1937781..1938836) uniprot|Q7Z8J4 Kluyveromyces lactis KLLA0F20790g gcr2 protein KLLA0F20812g 1 1939689 1941344 ON 6 F20812 (1939689..1941344) similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 Component of the septin ring of the mother- bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane and they comprise the 10nm filaments seen with EM KLLA0F20834g 0 1942016 1943866 ON 6 F20834 complement(1942016..1943866) some similarities with Saccharomyces cerevisiae YDL224C WHI4 and to uniprot|P34761 Saccharomyces cerevisiae YNL197C WHI3 KLLA0F20856g 0 1946043 1946801 ON 6 F20856 complement(1946043..1946801) conserved hypothetical protein KLLA0F20878g 0 1947379 1948821 ON 6 F20878 complement(1947379..1948821) no similarity KLLA0F20900g 0 1949668 1950480 ON 6 F20900 complement(1949668..1950480) some similarities with uniprot|Q07651 Saccharomyces cerevisiae YDL222C FMP45 The authentic non-tagged protein was localized to the mitochondria cell cortex protein not required for growth on nonfermentable carbon sources required for viability in stationary phase KLLA0F20922g 0 1951787 1954510 ON 6 F20922 complement(1951787..1954510) weakly similar to uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails regulates telomere replication through recruitment of specific sub-complexes but the essential function is telomere capping KLLA0F20944g 1 1954947 1956371 ON 6 F20944 (1954947..1956371) similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Hypothetical ORF KLLA0F20966g 1 1956869 1959895 ON 6 F20966 (1956869..1959895) similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I requires activation from zymogenic form in order to catalyze the transfer of N- acetylglucosamine (GlcNAc) to chitin required for repairing the chitin septum during cytokinesis transcription activated by mating factor KLLA0F20988g 0 1960417 1961406 ON 6 F20988 complement(1960417..1961406) uniprot|P17819 Kluyveromyces lactis KLLA0F20988g GAP1 Glyceraldehyde-3-phosphate dehydrogenase 1 KLLA0F21010g 1 1962951 1964003 ON 6 F21010 (1962951..1964003) uniprot|P20369 Kluyveromyces lactis KLLA0F21010g ADH1 Alcohol dehydrogenase 1 KLLA0F21032g 1 1964630 1965523 ON 6 F21032 (1964630..1965523) similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit KLLA0F21054g 0 1965623 1965940 ON 6 F21054 complement(1965623..1965940) similar to uniprot|Q3E835 Saccharomyces cerevisiae YOL086W-A Hypothetical ORF identified by homology. See FEBS Letters [2000] 487:31-36. KLLA0F21076g 1 1966373 1969036 ON 6 F21076 (1966373..1969036) weakly similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Hypothetical ORF KLLA0F21098g 1 1969578 1970225 ON 6 F21098 (1969578..1970225) highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27 common to RNA polymerases I II and III contacts DNA and affects transactivation KLLA0F21120g 0 1970487 1971245 ON 6 F21120 complement(1970487..1971245) similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase catalyzes the second step of the riboflavin biosynthesis pathway KLLA0F21142g 0 1971838 1972626 ON 6 F21142 complement(1971838..1972626) weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W SPP381 Suppressor of Pre-mRNA Processing mutant; U4/U6.U5-associated snRNP protein; contains a PEST proteolysis motif KLLA0F21164g 0 1973018 1974280 ON 6 F21164 complement(1973018..1974280) conserved hypothetical protein KLLA0F21208g 1 1975203 1980527 ON 6 F21208 (1975203..1980527) similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA KLLA0F21230g 1 1980954 1981691 ON 6 F21230 (1980954..1981691) similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function interacts with Gea1p and Gea2p required for localization of Gea2p computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting KLLA0F21252g 0 1981872 1983266 ON 6 F21252 complement(1981872..1983266) conserved hypothetical protein KLLA0F21274g 0 1984163 1988971 ON 6 F21274 complement(1984163..1988971) similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D catalyzes the hydrolysis of phosphatidylcholine producing choline and phosphatidic acid involved in Sec14p-independent secretion required for meiosis and spore formation differently regulated in secretion and meiosis KLLA0F21296g 1 1990998 1992512 ON 6 F21296 (1990998..1992512) some similarities with uniprot|P42944 Saccharomyces cerevisiae YJL110C GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p KLLA0F21318g 1 1992956 1993570 ON 6 F21318 (1992956..1993570) similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein- sorting (Vps) pathway associates reversibly with the late endosome has human ortholog that may be altered in breast tumors KLLA0F21340g 0 1993659 1995314 ON 6 F21340 complement(1993659..1995314) highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex Klac_6.trna22L 1 1995860 1995975 ON 6 tL-CAA (1995860..1995897,1995932..1995975) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.52 KLLA0F21406g 0 1996260 1998377 ON 6 F21406 complement(1996260..1998377) similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W MDV1 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission KLLA0F21428g 0 1998804 1999631 ON 6 F21428 complement(1998804..1999631) similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Component of Dam1p complex important for spindle and kinetochore integrity localized to nuclear side of spindle pole body and along mitotic spindle KLLA0F21450g 0 1999977 2001134 ON 6 F21450 complement(1999977..2001134) highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Putative glycoprotease that interacts with Bud32p which is a member of the novel protein kinase piD261 family Klac_6.trna23D 0 2001472 2001543 ON 6 tD-GUC complement(2001472..2001543) tRNA Type: Asp (D) | Anti-Codon: GUC | Cove Score: 65.00 Klac_6.trna24R 0 2001557 2001628 ON 6 tR-UCU complement(2001557..2001628) tRNA Type: Arg (R) | Anti-Codon: UCU | Cove Score: 69.00 Klac_6.trna25P 1 2002117 2002238 ON 6 tP-UGG (2002117..2002152,2002203..2002238) tRNA Type: Pro (P) | Anti-Codon: UGG | Cove Score: 59.72 KLLA0F21560g 1 2002551 2004077 ON 6 F21560 (2002551..2004077) some similarities with uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway KLLA0F21582g 0 2004309 2005157 ON 6 F21582 complement(2004309..2005157) similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit KLLA0F21604g 1 2005981 2006640 ON 6 F21604 (2005981..2006640) some similarities with uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex involved in the modification and cleavage of the 18S pre-rRNA KLLA0F21626g 0 2006961 2008040 ON 6 F21626 complement(2006961..2008040) similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Hypothetical ORF KLLA0F21648g 0 2008351 2012016 ON 6 F21648 complement(2008351..2012016) highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p Far1p and Pho4p cargo dissociation involves binding to RanGTP KLLA0F21670g 0 2012737 2013615 ON 6 F21670 complement(2012737..2013615) highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly of the large ribosomal subunit contains a sigma(70)-like motif which is thought to bind RNA KLLA0F21692g 0 2014152 2018729 ON 6 F21692 complement(2014152..2018729) uniprot|Q96WM8 Kluyveromyces lactis KLLA0F21692g Pdr5 Multidrug pump KlPDR5 KLLA0F21714g 1 2020262 2022271 ON 6 F21714 (2020262..2022271) conserved hypothetical protein KLLA0F21736g 0 2022575 2022922 ON 6 F21736 complement(2022575..2022922) similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W Hypothetical ORF KLLA0F21758g 0 2023805 2028523 ON 6 F21758 complement(2023805..2028523) similar to uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase KLLA0F21802g 1 2029687 2031519 ON 6 F21802 (2029687..2031519) similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W Hypothetical ORF KLLA0F21824g 0 2031719 2032549 ON 6 F21824 complement(2031719..2032549) conserved hypothetical protein KLLA0F21846g 0 2033135 2034265 ON 6 F21846 complement(2033135..2034265) similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Core interacting component 1 ribosome biogenesis protein KLLA0F21868g 1 2035168 2035683 ON 6 F21868 (2035168..2035683) similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Protein of unknown function deletion inhibits Brome mosaic virus expression KLLA0F21890g 0 2036621 2037064 ON 6 F21890 complement(2036621..2037064) similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase which is the terminal member of the mitochondrial inner membrane electron transport chain expression is regulated by oxygen levels Klac_YGOB_Anc_5.281 0 2038203 2038838 ON 6 Anc_5.281 complement(2038203..2038838) ANNOTATED BY YGOB - KLLA0F21934g 1 2039116 2039718 ON 6 F21934 (2039116..2039718) similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W RBF22 Hypothetical ORF KLLA0F21956g 1 2040151 2042310 ON 6 F21956 (2040151..2042310) similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W Essential protein of unknown function KLLA0F21978g 1 2042656 2044929 ON 6 F21978 (2042656..2044929) similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway dolichyl phosphate-D- mannose:protein O-D-mannosyltransferase KLLA0F22000g 0 2044973 2047354 ON 6 F22000 complement(2044973..2047354) similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Elongator protein part of the six-subunit RNA polymerase II Elongator histone acetyltransferase complex target of Kluyveromyces lactis zymocin KLLA0F22022g 0 2047835 2049586 ON 6 F22022 complement(2047835..2049586) highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids KLLA0F22066g 0 2051033 2062327 ON 6 F22066 complement(2051033..2062327) similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Histone acetyltransferase component putative ortholog of human TRRAP which is an essential cofactor of c-Myc KLLA0F22088g 1 2064310 2065986 ON 6 F22088 (2064310..2065986) weakly similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease located in the cytoplasm and endoplasmic reticulum KLLA0F22110g 1 2066619 2069372 ON 6 F22110 (2066619..2069372) similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Member of the Sec24p family forms a complex with Sec23p that is involved in sorting of Pma1p into COPII vesicles peripheral ER membrane protein potential Cdc28p substrate KLLA0F22154g 1 2069922 2072507 ON 6 F22154 (2069922..2070232,2071226..2072507) similar to uniprot|Q66RD5 Saccharomyces cerevisiae YDR348C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate KLLA0F22176g 0 2073042 2073926 ON 6 F22176 complement(2073042..2073926) similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit MRP1 exhibits genetic interactions with PET122 encoding a COX3-specific translational activator and with PET123 encoding a small subunit mitochondrial ribosomal protein KLLA0F22198g 1 2075028 2077334 ON 6 F22198 (2075028..2077334) similar to gnl|GLV|DEHA0F25982g Debaryomyces hansenii DEHA0F25982g KLLA0F22220g 0 2077500 2078861 ON 6 F22220 complement(2077500..2078861) similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins KLLA0F22242g 0 2079462 2080118 ON 6 F22242 complement(2079462..2080118) similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 NAD( ) salvage pathway gene pyrazinamidase and nicotinamidase KLLA0F22275g 1 2080657 2082984 ON 6 F22275 (2080657..2082984) weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Mtf1 Two Hybrid Clone 2 KLLA0F22297g 0 2083448 2085547 ON 6 F22297 complement(2083448..2085547) similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role member of the LAMMER family of protein kinases which are serine/threonine kinases also capable of phosphorylating tyrosine residues KLLA0F22319g 0 2086613 2087224 ON 6 F22319 complement(2086613..2087224) some similarities with uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Hypothetical ORF KLLA0F22341g 0 2088007 2088966 ON 6 F22341 complement(2088007..2088966) no similarity KLLA0F22363g 0 2089476 2090693 ON 6 F22363 complement(2089476..2090693) some similarities with uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p- Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC) required for nuclear export of ribosomes KLLA0F22385g 1 2091235 2095596 ON 6 F22385 (2091235..2095596) similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 5'-3' exonuclease involved in mRNA decay evolutionarily conserved component of cytoplasmic processing (P) bodies plays a role in microtubule-mediated processes filamentous growth and ribosomal RNA maturation KLLA0F22407g 0 2095693 2096499 ON 6 F22407 complement(2095693..2096499) weakly similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Protein involved in bud-site selection diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern KLLA0F22429g 1 2096803 2097852 ON 6 F22429 (2096803..2097852) weakly similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Protein with a role in accurate meiotic and mitotic double-strand break repair phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents KLLA0F22451g 1 2098204 2099559 ON 6 F22451 (2098204..2099559) similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p- Spc25p) involved in chromosome segregation spindle checkpoint activity and kinetochore clustering KLLA0F22473g 0 2099623 2100384 ON 6 F22473 complement(2099623..2100384) similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex required for spliceosome assembly KLLA0F22495g 0 2100746 2102089 ON 6 F22495 complement(2100746..2101186,2101529..2102089) similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit KLLA0F22539g 1 2102745 2104670 ON 6 F22539 (2102745..2104670) some similarities with uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion localizes to the spindle pole body half bridge interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p KLLA0F22561g 1 2105219 2106844 ON 6 F22561 (2105219..2106844) weakly similar to uniprot|P47071 Saccharomyces cerevisiae YJL016W KLLA0F22583g 1 2107305 2108909 ON 6 F22583 (2107305..2108909) highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex related to Tcp1p required for the assembly of actin and tubulins in vivo KLLA0F22605g 0 2109034 2111913 ON 6 F22605 complement(2109034..2111913) similar to uniprot|P41695 Saccharomyces cerevisiae YGR188C BUB1 Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage associates with centromere DNA via Skp1p KLLA0F22627g 0 2112336 2114525 ON 6 F22627 complement(2112336..2114525) highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Phosphate metabolism transcription is regulated by PHO system polyphosphate synthetase (putative) KLLA0F22649g 0 2114753 2115220 ON 6 F22649 complement(2114753..2115220) similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17 physically interacts with C31 C11 and TFIIIB70 may be involved in the recruitment of pol III by the preinitiation complex KLLA0F22671g 0 2115530 2116930 ON 6 F22671 complement(2115530..2116930) similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Putative glycosidase of the cell wall may have a role in cell wall architecture Klac_6.trna26L 0 2117717 2117832 ON 6 tL-CAA complement(2117717..2117760,2117795..2117832) tRNA Type: Leu (L) | Anti-Codon: CAA | Cove Score: 54.52 Klac_6.trna27V 0 2118056 2118129 ON 6 tV-AAC complement(2118056..2118129) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 Klac_6.trna28H 0 2118168 2118239 ON 6 tH-GUG complement(2118168..2118239) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 68.23 KLLA0F22792g 1 2118783 2119145 ON 6 F22792 (2118783..2119145) some similarities with uniprot|Q04814 Saccharomyces cerevisiae YMR252C Hypothetical ORF KLLA0F22814g 0 2119266 2119736 ON 6 F22814 complement(2119266..2119736) highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin- associated adaptor complex AP-1 which is involved in protein sorting at the trans-Golgi network homolog of the sigma subunit of the mammalian clathrin AP-1 complex KLLA0F22836g 0 2120129 2121025 ON 6 F22836 complement(2120129..2121025) highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) not essential for viability GFP-Dph5p fusion protein localizes to the cytoplasm KLLA0F22858g 1 2121352 2123118 ON 6 F22858 (2121352..2123118) weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Hypothetical ORF KLLA0F22880g 1 2123577 2127071 ON 6 F22880 (2123577..2127071) some similarities with uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 KLLA0F22902g 0 2127147 2128682 ON 6 F22902 complement(2127147..2128682) conserved hypothetical protein KLLA0F22924g 1 2129434 2130021 ON 6 F22924 (2129434..2130021) similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein homologous to mammalian peroxisomal membrane protein Mpv17 required for ethanol metabolismand induced by heat shock localized to the inner mitochondrial membrane KLLA0F22946g 1 2130327 2132018 ON 6 F22946 (2130327..2132018) similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Hypothetical ORF KLLA0F22968g 0 2132132 2133136 ON 6 F22968 complement(2132132..2133136) similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Hypothetical ORF KLLA0F22990g 1 2134385 2138146 ON 6 F22990 (2134385..2138146) uniprot|Q6DR96 Kluyveromyces lactis HAP1 KLLA0F23012g 1 2138821 2140566 ON 6 F23012 (2138821..2140566) conserved hypothetical protein KLLA0F23034g 0 2140638 2142164 ON 6 F23034 complement(2140638..2142164) weakly similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W Hypothetical ORF Klac_6.trna29G 1 2142776 2142846 ON 6 tG-GCC (2142776..2142846) tRNA Type: Gly (G) | Anti-Codon: GCC | Cove Score: 66.84 KLLA0F23078g 1 2143618 2144517 ON 6 F23078 (2143618..2144517) similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Hypothetical ORF KLLA0F23089g 1 2145083 2146084 ON 6 F23089 (2145083..2146084) some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Hypothetical ORF KLLA0F23111g 1 2151398 2153464 ON 6 F23111 (2151398..2153464) conserved hypothetical protein KLLA0F23133g 1 2154515 2156623 ON 6 F23133 (2154515..2156623) highly similar to uniprot|P23337 Saccharomyces cerevisiae or YLR258W uniprot|P27472 Saccharomyces cerevisiae KLLA0F23155g 1 2157146 2158429 ON 6 F23155 (2157146..2158429) similar to uniprot|P22517 Saccharomyces cerevisiae YOL016C CMK2 Calmodulin-dependent protein kinase and uniprot|P27466 Saccharomyces cerevisiae YFR014C CMK1 Klac_6.trna30M 1 2159002 2159074 ON 6 tM-CAU (2159002..2159074) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 73.94 KLLA0F23199g 0 2159245 2162067 ON 6 F23199 complement(2159245..2162067) some similarities with uniprot|P43596 Saccharomyces cerevisiae YFR013W IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome has homology to Esc8p which is involved in silencing KLLA0F23221g 1 2163234 2164850 ON 6 F23221 (2163234..2164850) some similarities with uniprot|O13581 Saccharomyces cerevisiae YDL128W VCX1 Vacuolar H+/Ca2+ exchanger, has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter KLLA0F23243g 1 2165407 2170368 ON 6 F23243 (2165407..2170368) highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I subunit largest subunit of RNA polymerase I KLLA0F23265g 0 2170525 2173428 ON 6 F23265 complement(2170525..2173428) similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining homolog of bacterial IF2 KLLA0F23287g 1 2174090 2175199 ON 6 F23287 (2174090..2175199) highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 GTPase that interacts with ribosomes member of the DRG family of GTP-binding proteins KLLA0F23309g 0 2175773 2176759 ON 6 F23309 complement(2175773..2176759) similar to uniprot|Q12182 Saccharomyces cerevisiae YOR342C Hypothetical ORF KLLA0F23331g 1 2177477 2178658 ON 6 F23331 (2177477..2178658) no similarity KLLA0F23353g 0 2178959 2179804 ON 6 F23353 complement(2178959..2179804) uniprot|Q92242 Kluyveromyces lactis SCK1 Multicopy supressor of caseine kinase 1 mutation and weakly similar to uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 may be involved in glycolytic gene expression TYE7 a 33 kDa serine-rich protein is a potential member of the basic region/helix-loop-helix/leucine-zipper protein family KLLA0F23375g 1 2181986 2184475 ON 6 F23375 (2181986..2184475) similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase forms a complex with the subunits of DNA polymerase zeta Rev3p and Rev7p involved in repair of abasic sites in damaged DNA KLLA0F23397g 0 2184751 2186256 ON 6 F23397 complement(2184751..2186256) uniprot|Q875M9 Kluyveromyces lactis KLLA0F23397g PYK1 Pyruvate kinase KLLA0F23419g 0 2187386 2189107 ON 6 F23419 complement(2187386..2189107) similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 proline-specific permease (also capable of transporting alanine and glycine) putative proline- specific permease KLLA0F23441g 1 2191499 2192845 ON 6 F23441 (2191499..2192845) conserved hypothetical protein KLLA0F23463g 1 2193239 2196280 ON 6 F23463 (2193239..2196280) weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding isolated as mutant with increased chromosome loss and sensitivity to benomyl KLLA0F23485g 0 2196285 2198192 ON 6 F23485 complement(2196285..2198192) conserved hypothetical protein KLLA0F23507g 0 2198603 2200066 ON 6 F23507 complement(2198603..2200066) similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase functions in meiotic checkpoint KLLA0F23529g 1 2200946 2202775 ON 6 F23529 (2200946..2202775) highly similar to uniprot|P06208 Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2- isopropylmalate synthase) the main isozyme responsible for the first step in the leucine biosynthesis pathway KLLA0F23551g 1 2203276 2206557 ON 6 F23551 (2203276..2206557) similar to uniprot|Q12271 YOR109w Saccharomyces cerevisiae INP53 Phosphatidylinositol 4,5-bisphosphate 5- phosphatase KLLA0F23573g 1 2206864 2207460 ON 6 F23573 (2206864..2207460) conserved hypothetical protein KLLA0F23584g 0 2207441 2208103 ON 6 F23584 complement(2207441..2208103) similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex may function to antagonize silencing near telomeres interacts directly with Swc4p has homology to human leukemogenic protein AF9 contains a YEATS domain KLLA0F23606g 1 2208465 2209637 ON 6 F23606 (2208465..2209637) similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W KLLA0F23628g 1 2209790 2210431 ON 6 F23628 (2209790..2210431) similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Hypothetical ORF KLLA0F23650g 1 2210563 2211501 ON 6 F23650 (2210563..2211501) similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles involved in 60S ribosomal subunit biogenesis localizes to both nucleolus and cytoplasm KLLA0F23672g 1 2212223 2212594 ON 6 F23672 (2212223..2212594) similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 involved in the sterol and lipid biosynthesis pathways required for sterol C5-6 and fatty acid desaturation KLLA0F23694g 1 2213137 2215302 ON 6 F23694 (2213137..2215302) similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W Hypothetical ORF KLLA0F23716g 0 2215454 2218129 ON 6 F23716 complement(2215454..2215845,2216857..2218129) similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family involved in nonsense-mediated mRNA decay and rRNA processing KLLA0F23760g 0 2218555 2218938 ON 6 F23760 complement(2218555..2218938) similar to uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit common to RNA polymerases I and III KLLA0F23782g 1 2219920 2222268 ON 6 F23782 (2219920..2222268) weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor involved in induction of CLN3 transcription in response to glucose genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance KLLA0F23804g 1 2222945 2223757 ON 6 F23804 (2222945..2223757) similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Hypothetical ORF KLLA0F23826g 0 2223868 2224680 ON 6 F23826 complement(2223868..2224680) similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 Component of the targeting complex (TRAPP) involved in ER to Golgi membrane traffic KLLA0F23848g 1 2224951 2226900 ON 6 F23848 (2224951..2226900) similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization able to recruit actin polymerization machinery through its SH3 domains colocalizes with cortical actin patches and Las17p interacts with type I myosins KLLA0F23870g 1 2227310 2229253 ON 6 F23870 (2227310..2229253) similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Hypothetical ORF KLLA0F23892g 0 2229493 2231049 ON 6 F23892 complement(2229493..2231049) some similarities with uniprot|P53924 Saccharomyces cerevisiae YNL116W DMA2 Protein involved in regulating spindle position and orientation functionally redundant with Dma1p homolog of S. pombe Dma1 and H. sapiens Chfr KLLA0F23914g 0 2232014 2233681 ON 6 F23914 complement(2232014..2233681) highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase enzyme of the glyoxylate cycle involved in utilization of non- fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium KLLA0F23980g 1 2235183 2237615 ON 6 F23980 (2235183..2237615) similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Protein required for the decapping of mRNAs functions to allow the production of active Dcp1p contains a pyrophosphatase MutT motif and several alpha-helical leucine-rich motifs KLLA0F24002g 0 2237722 2239113 ON 6 F24002 complement(2237722..2239113) similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein with a role in urmylation and in invasive and pseudohyphal growth inhibits replication of Brome mosaic virus in S. cerevisiae which is a model system for studying replication of positive-strand RNA viruses in their natural hosts KLLA0F24024g 1 2239420 2239788 ON 6 F24024 (2239420..2239788) similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis essential for functional cytochrome oxidase expression homologous to Cox17p KLLA0F24046g 1 2240454 2242268 ON 6 F24046 (2240454..2242268) similar to uniprot|P07213 Saccharomyces cerevisiae YNL121C TOM70 Translocase of Outer Mitochondrial membrane 70 kDa mitochondrial specialized import receptor of the outer membrane KLLA0F24068g 1 2242939 2243226 ON 6 F24068 (2242939..2243226) similar to uniprot|P53921 Saccharomyces cerevisiae YNL122C Hypothetical ORF KLLA0F24090g 0 2243449 2246406 ON 6 F24090 complement(2243449..2246406) similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W shows protein sequence similarity to the mammalian Omi/HtrA2 family of serine proteases KLLA0F24112g 0 2246666 2247916 ON 6 F24112 complement(2246666..2247916) similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing may be phosphorylated by Cdc28p KLLA0F24134g 1 2248261 2251263 ON 6 F24134 (2248261..2251263) similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase subunit of the COMPASS complex which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres contains a SET domain KLLA0F24156g 1 2251454 2254276 ON 6 F24156 (2251454..2254276) similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis KLLA0F24178g 0 2254372 2255829 ON 6 F24178 complement(2254372..2255829) some similarities with uniprot|P53919 Saccharomyces cerevisiae YNL124W NAF1 Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p KLLA0F24200g 1 2257007 2258965 ON 6 F24200 (2257007..2258965) similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases appears not to be involved in transport of monocarboxylates such as lactate pyruvate or acetate across the plasma membrane KLLA0F24222g 0 2259017 2261497 ON 6 F24222 complement(2259017..2261497) similar to uniprot|P53540 YNL126W Saccharomyces cerevisiae SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex KLLA0F24244g 0 2261810 2264593 ON 6 F24244 complement(2261810..2264593) similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far3p Far7p Far8p Far9p and Far10p KLLA0F24266g 1 2265002 2265559 ON 6 F24266 (2265002..2265559) similar to uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein containing an Lsm domain and an AD domain may bind RNA and have a role in RNA processing KLLA0F24288g 0 2265719 2267020 ON 6 F24288 complement(2265719..2267020) similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W KLLA0F24310g 0 2267285 2268013 ON 6 F24310 complement(2267285..2268013) similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase catalyzes the synthesis of nicotinamide nucleotide (NMN) from nicotinamide riboside involved in a salvage pathway for NAD biosynthesis KLLA0F24332g 1 2268391 2269074 ON 6 F24332 (2268391..2269074) similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein required for cell viability KLLA0F24354g 1 2269337 2270621 ON 6 F24354 (2269337..2269386,2269514..2270621) similar to uniprot|P17898 Saccharomyces cerevisiae YNL130C CPT1 and similar to uniprot|P22140 Saccharomyces cerevisiae YHR123w EPT1 Cholinephosphotransferase KLLA0F24376g 0 2270907 2271371 ON 6 F24376 complement(2270907..2271371) similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Translocase of Outer Mitochondrial membrane Mitochondrial import receptor complex protein KLLA0F24398g 0 2271709 2274876 ON 6 F24398 complement(2271709..2274876) highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein of unknown function heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance KLLA0F24420g 1 2275736 2277472 ON 6 F24420 (2275736..2277472) some similarities with uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination activates middle sporulation genes competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) KLLA0F24442g 1 2277836 2278330 ON 6 F24442 (2277836..2278330) weakly similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function required for survival upon exposure to K1 killer toxin proposed to regulate double-strand break repair via non- homologous end-joining KLLA0F24464g 1 2278745 2279857 ON 6 F24464 (2278745..2279857) similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C similarity to dehydrogenases KLLA0F24486g 0 2280372 2281223 ON 6 F24486 complement(2280372..2281223) some similarities with uniprot|P47179 Saccharomyces cerevisiae YJR151C DAN4 Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p KLLA0F24509g 1 2282652 2283091 ON 6 F24509 (2282652..2282871,2282961..2283091) some similarities with uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain Klac_6.trna31N 0 2283263 2283336 ON 6 tN-GUU complement(2283263..2283336) tRNA Type: Asn (N) | Anti-Codon: GUU | Cove Score: 77.01 KLLA0F24552g 0 2283569 2284717 ON 6 F24552 complement(2283569..2284717) similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase member of the medium chain dehydrogenase/reductase family localized to in mitochondria where it has a probable role in fatty acid synthesis KLLA0F24574g 0 2285387 2287522 ON 6 F24574 complement(2285387..2287522) similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1 2-mannosyltransferase responsible for addition of the first alpha-1 2-linked mannose to form the branches on the mannan backbone of oligosaccharides localizes to an early Golgi compartment KLLA0F24596g 1 2288293 2288802 ON 6 F24596 (2288293..2288802) conserved hypothetical protein KLLA0F24618g 0 2288943 2290613 ON 6 F24618 complement(2288943..2290613) similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C Hypothetical ORF KLLA0F24640g 0 2291186 2292508 ON 6 F24640 complement(2291186..2292508) similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP- diglyceride synthetase) an enzyme that catalyzes that conversion of CTP phosphate into diphosphate CDP- diaclglyerol a critical step in the synthesis of all major yeast phospholipids KLLA0F24662g 0 2292807 2294399 ON 6 F24662 complement(2292807..2294399) similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex required for spliceosome assembly KLLA0F24684g 0 2294708 2297629 ON 6 F24684 complement(2294708..2297629) similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Essential protein involved in ribosome biogenesis KLLA0F24706g 1 2298224 2299471 ON 6 F24706 (2298224..2299471) similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 Mitochondrial protein with a potential role in protein synthesis the bacterial homolog is responsible for the 2-thiolation of mnm5s2U34 in tRNALys tRNAGlu and tRNAGln KLLA0F24728g 1 2299815 2300906 ON 6 F24728 (2299815..2300906) similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine- 5'-phosphosulfate intermediates of the sulfate assimilation pathway KLLA0F24750g 1 2301851 2304451 ON 6 F24750 (2301851..2304451) similar to uniprot|Q757V1 Ashbya gossypii AEL089C AEL089Cp and some similarites with YDL035C uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G- protein coupled receptor that interacts with the heterotrimeric G protein alpha subunit Gpa2p and with Plc1p sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis KLLA0F24772g 1 2304733 2305863 ON 6 F24772 (2304733..2305863) similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4 5-bisphosphate 5- phosphatase with a role in secretion localizes to the endoplasmic reticulum via the C-terminal tail lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins KLLA0F24794g 1 2306055 2307848 ON 6 F24794 (2306055..2307848) similar to uniprot|Q12362 Saccharomyces cerevisiae and weakly similar to YDL036C uniprot|Q12069 Saccharomyces cerevisiae YDL036C Hypothetical ORF KLLA0F24816g 1 2308342 2309778 ON 6 F24816 (2308342..2309778) similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end KLLA0F24838g 0 2309842 2313030 ON 6 F24838 complement(2309842..2313030) similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase component that with Itc1p forms a complex required for repression of a-specific genes INO1 and early meiotic genes during mitotic growth KLLA0F24860g 0 2313713 2317357 ON 6 F24860 complement(2313713..2317357) conserved hypothetical protein KLLA0F24882g 0 2317798 2319027 ON 6 F24882 complement(2317798..2319027) similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader, member of GLC.2530 Klac_YGOB_Anc_8.775 0 2319020 2319097 ON 6 Anc_8.775 complement(2319020..2319097) ANNOTATED BY YGOB - KLLA0F24904g 0 2319858 2321132 ON 6 F24904 complement(2319858..2321132) similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding localization requires Rax2p KLLA0F24926g 0 2321928 2323283 ON 6 F24926 complement(2321928..2323283) similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Mannosidase essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis involved in filamentous growth homologous to Dcw1p KLLA0F24948g 0 2323980 2324480 ON 6 F24948 complement(2323980..2324480) similar to uniprot|Q88DE0 Pseudomonas putida PP4887 PP_4887 Hypothetical protein KLLA0F24981g 0 2325340 2327283 ON 6 F24981 complement(2325340..2327283) similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W BUD7 Protein involved in bud-site selection diploid mutants display an axial-like budding pattern KLLA0F25003g 0 2327810 2328208 ON 6 F25003 complement(2327810..2328208) highly similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9 KLLA0F25014g 1 2328545 2328997 ON 6 F25014 (2328545..2328997) some similarities with uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations KLLA0F25036g 1 2329465 2330634 ON 6 F25036 (2329465..2330634) similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p involved in nuclear transport KLLA0F25058g 0 2330789 2331805 ON 6 F25058 complement(2330789..2331805) weakly similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acetyltransferases KLLA0F25080g 1 2332264 2332845 ON 6 F25080 (2332264..2332845) some similarities with uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 mitochondrial inner membrane translocase KLLA0F25102g 1 2333488 2334798 ON 6 F25102 (2333488..2334798) similar to uniprot|P06842 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone seven transmembrane-domain protein that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells KLLA0F25124g 0 2334954 2337881 ON 6 F25124 complement(2334954..2337881) similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation prevents production of vesicles with defective subunits required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules KLLA0F25146g 0 2338211 2340631 ON 6 F25146 complement(2338211..2340631) similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4 which is an essential histone H4/H2A acetyltransferase complex homologous to Drosophila Enhancer of Polycomb KLLA0F25168g 1 2341386 2343614 ON 6 F25168 (2341386..2343614) similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Protein involved in bud-site selection nutrient signaling and gene expression controlled by the TOR kinase diploid mutants display a random budding pattern instead of the wild-type bipolar pattern KLLA0F25190g 1 2345059 2346723 ON 6 F25190 (2345059..2346723) conserved hypothetical protein KLLA0F25212g 1 2347143 2349122 ON 6 F25212 (2347143..2349122) some similarities with uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall KLLA0F25234g 0 2349192 2350691 ON 6 F25234 complement(2349192..2350691) highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C KLLA0F25256g 0 2351009 2351602 ON 6 F25256 complement(2351009..2351602) weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex KLLA0F25278g 1 2352045 2352719 ON 6 F25278 (2352045..2352719) similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C Protein required for cell viability KLLA0F25300g 1 2354118 2356196 ON 6 F25300 (2354118..2356196) some similarities with uniprot|P43574 Saccharomyces cerevisiae YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression member of the GATA family of DNA binding proteins activity and localization regulated by nitrogen limitation and Ure2p KLLA0F25322g 0 2356566 2360375 ON 6 F25322 complement(2356566..2360375) similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W Klac_6.trna32E 0 2360816 2360887 ON 6 tE-UUC complement(2360816..2360887) tRNA Type: Glu (E) | Anti-Codon: UUC | Cove Score: 62.99 KLLA0F25366g 1 2361279 2361953 ON 6 F25366 (2361279..2361953) similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 involved in secretion KLLA0F25388g 0 2362150 2363367 ON 6 F25388 complement(2362150..2363367) some similarities with uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes KLLA0F25410g 1 2363911 2365374 ON 6 F25410 (2363911..2365374) conserved hypothetical protein KLLA0F25432g 0 2365434 2366957 ON 6 F25432 complement(2365434..2366957) some similarities with uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 homologous to the medium chain of mammalian clathrin-associated protein complex Similar to clathrin coat proteins KLLA0F25454g 1 2367059 2367586 ON 6 F25454 (2367059..2367586) similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Hypothetical ORF KLLA0F25476g 0 2367737 2368507 ON 6 F25476 complement(2367737..2368507) similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C KLLA0F25498g 1 2368996 2370501 ON 6 F25498 (2368996..2370501) similar to uniprot|P32857 Saccharomyces cerevisiae YKL039W PTM1 Putative membrane protein KLLA0F25520g 0 2370884 2372155 ON 6 F25520 complement(2370884..2372155) conserved hypothetical protein KLLA0F25542g 1 2372720 2373073 ON 6 F25542 (2372720..2373073) similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20 KLLA0F25564g 0 2374193 2375422 ON 6 F25564 complement(2374193..2375422) similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1 KLLA0F25586g 0 2375616 2376569 ON 6 F25586 complement(2375616..2376569) similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C Hypothetical ORF Klac_6.trna33M 0 2376761 2376832 ON 6 tM-CAU complement(2376761..2376832) tRNA Type: Met (M) | Anti-Codon: CAU | Cove Score: 74.96 KLLA0F25630g 1 2378464 2381487 ON 6 F25630 (2378464..2381487) some similarities with uniprot|P32862 Saccharomyces cerevisiae YKL038W RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor KLLA0F25652g 1 2382288 2383790 ON 6 F25652 (2382288..2383790) highly similar to uniprot|P32861 Saccharomyces cerevisiae YKL035W UGP1 UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase EC:2.7.7.9 KLLA0F25674g 1 2384293 2386566 ON 6 F25674 (2384293..2386566) similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Transmembrane Ubiquitin Ligase KLLA0F25696g 1 2386886 2387554 ON 6 F25696 (2386886..2387554) conserved hypothetical protein KLLA0F25718g 0 2387821 2388783 ON 6 F25718 complement(2387821..2388783) highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)- pyrophosphate synthetase involved in nucleotide histidine and tryptophan biosynthesis one of a five related enzymes which are active as heteromultimeric complexes KLLA0F25740g 0 2389226 2390779 ON 6 F25740 complement(2389226..2390779) similar to uniprot|P38748 YHL010C Saccharomyces cerevisiae Hypothetical ORF KLLA0F25762g 1 2391115 2394126 ON 6 F25762 (2391115..2394126) weakly similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W Protein of unknown function localized to the cytoplasm. KLLA0F25784g 1 2395004 2397058 ON 6 F25784 (2395004..2397058) similar to uniprot|P38750 Saccharomyces cerevisiae YHL008C Hypothetical ORF KLLA0F25806g 1 2397560 2401294 ON 6 F25806 (2397560..2401294) similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion colocalizes with cohesin on chromosomes in an interdependent manner may function as a protein-protein interaction scaffold KLLA0F25828g 0 2401463 2403334 ON 6 F25828 complement(2401463..2403334) similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Nuclear protein of unknown function KLLA0F25850g 1 2403616 2404017 ON 6 F25850 (2403616..2404017) weakly similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Hypothetical ORF KLLA0F25872g 1 2404449 2404718 ON 6 F25872 (2404449..2404718) similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A MRS11 Essential protein of the mitochondrial intermembrane space forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane has homology to Mrs5p which is also involved in this process KLLA0F25894g 0 2405016 2405831 ON 6 F25894 complement(2405016..2405831) similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase involved in maturation of cytochrome c1 which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase links heme covalently to apocytochrome c1 KLLA0F25916g 1 2406597 2407940 ON 6 F25916 (2406597..2407940) uniprot|Q9Y7B7 Kluyveromyces lactis KLLA0F25916g GPA1 Guanine nucleotide-binding protein alpha-1 subunit KLLA0F25938g 1 2408281 2408679 ON 6 F25938 (2408281..2408679) similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants conserved in higher eukaryotes KLLA0F25960g 1 2409591 2410607 ON 6 F25960 (2409591..2410607) highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase catalyzes interconversion of malate and oxaloacetate involved in the tricarboxylic acid (TCA) cycle KLLA0F25982g 1 2410900 2411244 ON 6 F25982 (2410900..2411244) similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Mitochondrial intermembrane space protein first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex KLLA0F26004g 0 2411261 2412271 ON 6 F26004 complement(2411261..2412271) some similarities with uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins KLLA0F26026g 1 2412582 2413241 ON 6 F26026 (2412582..2413241) some similarities with uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p KLLA0F26048g 0 2413296 2415875 ON 6 F26048 complement(2413296..2415875) weakly similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Synthesis Of Var (putative) involved in respiration KLLA0F26070g 0 2416265 2417608 ON 6 F26070 complement(2416265..2417608) similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Required for normal pre-rRNA Processing Protein required for cell viability KLLA0F26092g 1 2418244 2420028 ON 6 F26092 (2418244..2418622,2418992..2420028) similar to uniprot|P36008 Saccharomyces cerevisiae YKL081W TEF4 Translation elongation factor EF-1gamma KLLA0F26114g 1 2420635 2421810 ON 6 F26114 (2420635..2421810) highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Vacuolar H ATPase subunit C of the catalytic (V1) sector KLLA0F26158g 1 2422976 2424154 ON 6 F26158 (2422976..2424154) similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 to Fe(II)-dependent sulfonate/alpha- ketoglutarate dioxygenase KLLA0F26180g 0 2424326 2425789 ON 6 F26180 complement(2424326..2425789) similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen may form a complex with Jem1p and Kar2p expression of the gene is regulated by pheromone KLLA0F26202g 0 2426058 2427530 ON 6 F26202 complement(2426058..2427530) weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase KLLA0F26224g 1 2428360 2430558 ON 6 F26224 (2428360..2430558) similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box RNA helicase required for 18S rRNA synthesis KLLA0F26246g 1 2432209 2433960 ON 6 F26246 (2432209..2433960) highly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane subject to glucose-induced inactivation strongly but transiently induced when cells are subjected to osmotic shock KLLA0F26268g 1 2434995 2436320 ON 6 F26268 (2434995..2436320) highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ECM40 Mitochondrial ornithine acetyltransferase catalyzes the fifth step in arginine biosynthesis also possesses acetylglutamate synthase activity regenerates acetylglutamate while forming ornithine KLLA0F26290g 0 2436415 2438400 ON 6 F26290 complement(2436415..2438400) similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends bridges interaction between Rna15p and Hrp1p in the CF I complex KLLA0F26312g 1 2438840 2439745 ON 6 F26312 (2438840..2439745) similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex required for the sorting of some proteins to the outer membrane after import by the TOM complex KLLA0F26334g 0 2439808 2440191 ON 6 F26334 complement(2439808..2440191) weakly similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease which is composed of Sen2p Sen15p Sen34p and Sen54p KLLA0F26356g 1 2440510 2441676 ON 6 F26356 (2440510..2441676) similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W KLLA0F26378g 0 2441942 2443060 ON 6 F26378 complement(2441942..2443060) similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Hypothetical ORF KLLA0F26400g 0 2443630 2445525 ON 6 F26400 complement(2443630..2445525) similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high- affinity iron uptake and involved in mediating resistance to copper ion toxicity belongs to class of integral membrane multicopper oxidases KLLA0F26422g 1 2447842 2448753 ON 6 F26422 (2447842..2448753) similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator forms GTPase- activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies blocks cell cycle progression before anaphase in response to spindle and kinetochore damage KLLA0F26433g 0 2448748 2450517 ON 6 F26433 complement(2448748..2450517) weakly similar to uniprot|P36084 Saccharomyces cerevisiae YKL074C KLLA0F26455g 1 2450871 2453462 ON 6 F26455 (2450871..2453462) similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen involved in polypeptide translocation and folding member of the Hsp70 family localizes to the lumen of the ER regulated by the unfolded protein response pathway KLLA0F26477g 0 2453526 2456141 ON 6 F26477 complement(2453526..2456141) similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit of vacuolar-ATPase V0 domain one of two isoforms (Stv1p and Vph1p) Stv1p is located in V- ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole KLLA0F26499g 1 2456560 2458689 ON 6 F26499 (2456560..2458689) similar to uniprot|P36085 Saccharomyces cerevisiae YKL072W STB6 and similar to uniprot|P46679 Saccharomyces cerevisiae YMR053c STB2 KLLA0F26521g 0 2458708 2459337 ON 6 F26521 complement(2458708..2459337) similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in G1 cell cycle arrest in response to pheromone in a pathway different from the Far1p-dependent pathway interacts with Far7p Far8p Far9p Far10p and Far11p Klac_6.trna34W 1 2459676 2459784 ON 6 tW-CCA (2459676..2459711,2459749..2459784) tRNA Type: Trp (W) | Anti-Codon: CCA | Cove Score: 66.54 KLLA0F26587g 1 2460142 2460672 ON 6 F26587 (2460142..2460672) highly similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Hypothetical ORF Klac_6.trna35V 0 2460826 2460899 ON 6 tV-AAC complement(2460826..2460899) tRNA Type: Val (V) | Anti-Codon: AAC | Cove Score: 68.42 KLLA0F26653g 1 2461876 2464251 ON 6 F26653 (2461876..2464251) similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Protein required for maturation of the 25S and 5.8S ribosomal RNAs homologous to mammalian Bop1 KLLA0F26675g 0 2464378 2465277 ON 6 F26675 complement(2464378..2465277) some similarities with uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Protein required for accurate chromosome segregation during meiosis KLLA0F26686g 1 2466251 2466490 ON 6 F26686 (2466251..2466490) some similarities with uniprot|Q3E826 Saccharomyces cerevisiae YKL068W-A Identified by homology to Ashbya gossypii KLLA0F26697g 1 2467247 2470639 ON 6 F26697 (2467247..2470639) weakly similar to uniprot|Q02629 Saccharomyces cerevisiae YKL068W NUP100 Subunit of the nuclear pore complex (NPC) Klac_6.trna36H 0 2470881 2470952 ON 6 tH-GUG complement(2470881..2470952) tRNA Type: His (H) | Anti-Codon: GUG | Cove Score: 68.23 KLLA0F26763g 0 2472250 2473575 ON 6 F26763 complement(2472250..2473575) weakly similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing contains a PWWP motif KLLA0F26807g 0 2474742 2475452 ON 6 F26807 complement(2474742..2475452) some similarities with uniprot|P11746 Saccharomyces cerevisiae YMR043W MCM1 Transcription factor involved in cell-type-specific transcription and pheromone response plays a central role in the formation of both repressor and activator complexes KLLA0F26818g 1 2477131 2477355 ON 6 F26818 (2477131..2477355) no similarity KLLA0F26829g 1 2477782 2478405 ON 6 F26829 (2477782..2478405) similar to uniprot|P35723 Saccharomyces cerevisiae YKL065C YET1 Endoplasmic reticulum transmembrane protein homolog of human BAP31 protein KLLA0F26851g 0 2478465 2479451 ON 6 F26851 complement(2478465..2479451) similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C Hypothetical ORF KLLA0F26873g 1 2480009 2480743 ON 6 F26873 (2480009..2480743) some similarities with uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Suppressor of TFIIB mutations transcriptional coactivator KLLA0F26895g 1 2481281 2484169 ON 6 F26895 (2481281..2484169) similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W KLLA0F26917g 1 2484542 2485279 ON 6 F26917 (2484542..2485279) similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p involved in oxidative stress protection Met-X-Cys-X2- Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation KLLA0F26939g 0 2485499 2486092 ON 6 F26939 complement(2485499..2486092) similar to uniprot|P35725 Saccharomyces cerevisiae YKL063C Hypothetical ORF KLLA0F26961g 1 2486804 2488888 ON 6 F26961 (2486804..2488888) weakly similar to uniprot|P33748 Saccharomyces cerevisiae YMR037C MSN2 Transcriptional activator related to Msn4p activated in stress conditions which results in translocation from the cytoplasm to the nucleus binds DNA at stress response elements of responsive genes inducing gene expression KLLA0F26983g 1 2489326 2490729 ON 6 F26983 (2489326..2490729) some similarities with uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis septin behavior and cytokinesis required for the regulation of other kinases forms part of the bud neck ring KLLA0F27005g 1 2491505 2493124 ON 6 F27005 (2491505..2493124) some similarities with uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control regulates the phosphorylation state of Cdc28p homolog of S. pombe cdc25 KLLA0F27027g 0 2493258 2493794 ON 6 F27027 complement(2493258..2493794) similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 mitochondrial peptidase KLLA0F27049g 1 2495105 2496457 ON 6 F27049 (2495105..2496457) similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Hypothetical ORF KLLA0F27071g 0 2496781 2499894 ON 6 F27071 complement(2496781..2499894) similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Hypothetical ORF KLLA0F27093g 1 2501049 2502740 ON 6 F27093 (2501049..2502740) similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions transcription is induced under conditions of sulfur limitation KLLA0F27115g 0 2502893 2504674 ON 6 F27115 complement(2502893..2504674) weakly similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Peripheral mitochondrial inner membrane protein located on the matrix face of the membrane stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex KLLA0F27137g 0 2505026 2508559 ON 6 F27137 complement(2505026..2508559) similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway involved in sphingolipid metabolism glycoprotein homologous to human Niemann Pick C1 (NPC) protein KLLA0F27159g 1 2508838 2510568 ON 6 F27159 (2508838..2510568) similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC) part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes linker between TauB and TauA domains human homolog is TFIIIC-90 KLLA0F27181g 0 2510636 2513059 ON 6 F27181 complement(2510636..2513059) similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W KLLA0F27203g 1 2514694 2515656 ON 6 F27203 (2514694..2515656) conserved hypothetical protein KLLA0F27225g 1 2517770 2519170 ON 6 F27225 (2517770..2519170) some similarities with uniprot|Q02606 Saccharomyces cerevisiae YPL014W Hypothetical ORF KLLA0F27247g 0 2519696 2520058 ON 6 F27247 complement(2519696..2520058) highly similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit KLLA0F27269g 1 2520782 2524432 ON 6 F27269 (2520782..2524432) similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for normal pre-rRNA Processing member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift KLLA0F27291g 0 2524625 2525674 ON 6 F27291 complement(2524625..2525674) similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa) involved in promoter binding and RNA polymerase II transcription initiation KLLA0F27313g 1 2526333 2526902 ON 6 F27313 (2526333..2526902) similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI) which coats Golgi-derived transport vesicles involved in retrograde transport between Golgi and ER KLLA0F27335g 0 2527145 2530228 ON 6 F27335 complement(2527145..2530228) similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C Hypothetical ORF KLLA0F27357g 1 2530948 2533560 ON 6 F27357 (2530948..2533560) similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation- dependent mRNA-decapping factor also required for faithful chromosome transmission maintenance of rDNA locus stability and protection of mRNA 3'-UTRs from trimming functionally linked to Pab1p KLLA0F27379g 1 2534020 2534913 ON 6 F27379 (2534020..2534913) weakly similar to uniprot|P25659 Saccharomyces cerevisiae YCR076C KLLA0F27390g 0 2535052 2535300 ON 6 F27390 complement(2535052..2535300) similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A Identified by homology to Ashbya gossypii KLLA0F27401g 1 2535549 2537219 ON 6 F27401 (2535549..2537219) conserved hypothetical protein KLLA0F27423g 0 2537353 2538891 ON 6 F27423 complement(2537353..2538891) some similarities with uniprot|P40530 Saccharomyces cerevisiae YIL042C Hypothetical ORF KLLA0F27445g 1 2539961 2540713 ON 6 F27445 (2539961..2540713) similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C KLLA0F27467g 0 2541110 2543644 ON 6 F27467 complement(2541110..2543644) similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency plasma membrane protein KLLA0F27489g 1 2544518 2545411 ON 6 F27489 (2544518..2545411) highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase a hexameric enzyme catalyzes the first step in histidine biosynthesis mutations cause histidine auxotrophy and sensitivity to Cu Co and Ni salts transcription is regulated by general amino acid control KLLA0F27511g 1 2546533 2548404 ON 6 F27511 (2546533..2548404) similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif controls cell cycle function sulfur metabolism and methionine biosynthesis as part of the ubiquitin ligase complex interacts with and regulates Met4p localizes within the nucleus KLLA0F27533g 1 2549457 2550953 ON 6 F27533 (2549457..2550953) weakly similar to uniprot|P40036 Saccharomyces cerevisiae YER054C GIP2 Putative regulatory subunit of the protein phosphatase Glc7p proposed to be involved in glycogen metabolism contains a conserved motif (GVNK motif) that is also found in Gac1p Pig1p and Pig2p Klac_YGOB_YER053C-A 1 2553291 2553404 ON 6 YER053C-A (2553291..2553404) ANNOTATED BY YGOB - KLLA0F27555g 0 2554571 2555410 ON 6 F27555 complement(2554571..2555410) similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector ARF GAP with effector function(s) KLLA0F27577g 1 2556662 2557180 ON 6 F27577 (2556662..2557180) some similarities with uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5 KLLA0F27599g 1 2558178 2559746 ON 6 F27599 (2558178..2559746) highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P- transferase) cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis expression regulated by Gcn4p and the general control of amino acid synthesis KLLA0F27621g 0 2560055 2560900 ON 6 F27621 complement(2560055..2560900) similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 cytochrome b reductase KLLA0F27643g 0 2561213 2562649 ON 6 F27643 complement(2561213..2562649) similar to uniprot|P40034 Saccharomyces cerevisiae YER051W Hypothetical ORF KLLA0F27665g 1 2563022 2566156 ON 6 F27665 (2563022..2566156) some similarities with uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins KLLA0F27687g 0 2566290 2569061 ON 6 F27687 complement(2566290..2569061) some similarities with uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein KLLA0F27709g 0 2569570 2570445 OFF 6 F27709 complement(2569570..2570445) weakly similar to with YIL030C uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Protein involved in mRNA turnover integral nuclear membrane protein Klac_6.trna37K 0 2570760 2570832 ON 6 tK-CUU complement(2570760..2570832) tRNA Type: Lys (K) | Anti-Codon: CUU | Cove Score: 79.43 KLLA0F27753g 1 2571155 2571496 ON 6 F27753 (2571155..2571496) weakly similar to uniprot|P14724 Saccharomyces cerevisiae YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) KLLA0F27775g 0 2571644 2572054 ON 6 F27775 complement(2571644..2572054) similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Protein of unknown function null mutant shows K1 killer toxin resistance KLLA0F27797g 0 2572415 2575720 ON 6 F27797 complement(2572415..2575720) similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms essential for viability KLLA0F27819g 0 2576382 2577056 ON 6 F27819 complement(2576382..2577056) similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Hypothetical ORF KLLA0F27841g 1 2578531 2579112 ON 6 F27841 (2578531..2579112) no similarity KLLA0F27863g 0 2579510 2580241 ON 6 F27863 complement(2579510..2580241) some similarities with uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 weak suppressor of smt3 KLLA0F27885g 1 2580668 2581438 ON 6 F27885 (2580668..2581438) similar to uniprot|P53898 Saccharomyces cerevisiae YNL156C NSG2 Protein of unknown function potential homolog of mammalian Insig 1 KLLA0F27907g 0 2581760 2582212 ON 6 F27907 complement(2581760..2582212) highly similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A Hypothetical ORF KLLA0F27929g 1 2583179 2584507 ON 6 F27929 (2583179..2584507) similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C KLLA0F27951g 0 2584589 2585161 ON 6 F27951 complement(2584589..2585161) weakly similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W Essential protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery KLLA0F27973g 1 2585445 2586146 ON 6 F27973 (2585445..2586146) some similarities with uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Predicted membrane protein KLLA0F27995g 1 2586722 2587954 ON 6 F27995 (2586722..2587954) conserved hypothetical protein KLLA0F28017g 1 2588273 2589466 ON 6 F28017 (2588273..2589466) similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W LPE10 Mitochondrial inner membrane magnesium transporter involved in maintenance of magnesium concentrations inside mitochondria indirectly affects splicing of group II introns functionally and structurally related to Mrs2p KLLA0F28039g 1 2590003 2591325 ON 6 F28039 (2590003..2591325) similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron forms complex with Fet5p expression is regulated by iron proposed to play indirect role in endocytosis KLLA0F28083g 0 2594274 2596370 ON 6 F28083 complement(2594274..2596370) similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane urea transporter expression is highly sensitive to nitrogen catabolite repression and induced by allophanate the last intermediate of the allantoin degradative pathway KLLA0F28105g 0 2599341 2599682 ON 6 F28105 complement(2599341..2599682) no similarity