YAL069W	1	335	649	OFF	1	YAL069W	(335..649)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL068W-A	1	538	792	OFF	1	YAL068W-A	(538..792)	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAL068C	0	1807	2169	ON	1	YAL068C	complement(1807..2169)	Hypothetical protein
YAL067W-A	1	2480	2707	OFF	1	YAL067W-A	(2480..2707)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAL067C	0	7236	9017	ON	1	SEO1	complement(7236..9017)	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YAL066W	1	10092	10400	OFF	1	YAL066W	(10092..10400)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL065C	0	11566	11952	ON	1	YAL065C	complement(11566..11952)	Putative protein of unknown function; has homology to FLO1; possible pseudogene
YAL064W-B	1	12047	12427	ON	1	YAL064W-B	(12047..12427)	Fungal-specific protein of unknown function
YAL064C-A	0	13364	13744	ON	1	YAL064C-A	complement(13364..13744)	Putative protein of unknown function; YAL064C-A is not an essential gene
YAL064W	1	21526	21852	ON	1	YAL064W	(21526..21852)	Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YAL063C-A	0	22397	22687	OFF	1	YAL063C-A	complement(22397..22687)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YAL063C	0	24001	27969	ON	1	FLO9	complement(24001..27969)	Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YAL062W	1	31568	32941	ON	1	GDH3	(31568..32941)	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL061W	1	33449	34702	ON	1	BDH2	(33449..34702)	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YAL060W	1	35156	36304	ON	1	BDH1	(35156..36304)	NAD-dependent (2R,3R)-2,3-butanediol dehydrogenase, a zinc-containing medium-chain alcohol dehydrogenase, produces 2,3-butanediol from acetoin during fermentation and allows using 2,3-butanediol as a carbon source during aerobic growth
YAL059C-A	0	36497	36919	OFF	1	YAL059C-A	complement(36497..36919)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W
YAL059W	1	36510	37148	ON	1	ECM1	(36510..37148)	Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YAL058W	1	37465	38973	ON	1	CNE1	(37465..38973)	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YAL056C-A	0	38697	39047	OFF	1	YAL056C-A	complement(38697..39047)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL056W	1	39260	41902	ON	1	GPB2	(39260..41902)	Proposed beta subunit of the heterotrimeric G protein; interacts with the receptor Grp1p, affects signaling by altering the level of phosphorylation of PKS substrates; regulates pseudohyphal growth through cAMP levels; homolog of Gpb1p
YAL055W	1	42178	42720	ON	1	PEX22	(42178..42720)	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
YAL054C	0	42882	45023	ON	1	ACS1	complement(42882..45023)	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YAL053W	1	45900	48251	ON	1	FLC2	(45900..48251)	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YAL051W	1	48565	51708	ON	1	OAF1	(48565..51708)	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
YAL049C	0	51856	52596	ON	1	YAL049C	complement(51856..52596)	Cytoplasmic protein of unknown function, potential Hsp82p interactor
YAL048C	0	52802	54790	ON	1	GEM1	complement(52802..54790)	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
YAL047W-A	1	54585	54914	OFF	1	YAL047W-A	(54585..54914)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL047C	0	54990	56858	ON	1	SPC72	complement(54990..56858)	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
YAL046C	0	57030	57386	ON	1	YAL046C	complement(57030..57386)	Putative protein of unknown function; YAL046C is not an essential gene
YAL045C	0	57489	57797	OFF	1	YAL045C	complement(57489..57797)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
YAL044W-A	1	57519	57851	ON	1	YAL044W-A	(57519..57851)	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
YAL044C	0	57951	58463	ON	1	GCV3	complement(57951..58463)	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YAL043C	0	58696	61053	ON	1	PTA1	complement(58696..61053)	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
YAL042C-A	0	61232	61609	OFF	1	YAL042C-A	complement(61232..61609)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene
YAL042W	1	61317	62564	ON	1	ERV46	(61317..62564)	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YAL041W	1	62841	65405	ON	1	CDC24	(62841..65405)	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
YAL040C	0	65779	67521	ON	1	CLN3	complement(65779..67521)	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YAL039C	0	68717	69526	ON	1	CYC3	complement(68717..69526)	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YAL038W	1	71787	73289	ON	1	CDC19	(71787..73289)	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YAL037C-B	0	72327	73301	OFF	1	YAL037C-B	complement(72327..73301)	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAL037C-A	0	73427	73519	OFF	1	YAL037C-A	complement(73427..73519)	Putative protein of unknown function
YAL037W	1	74021	74824	ON	1	YAL037W	(74021..74824)	Putative protein of unknown function
YAL036C	0	75044	76153	ON	1	RBG1	complement(75044..76153)	Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YAL035W	1	76428	79436	ON	1	FUN12	(76428..79436)	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YAL034C-B	0	79490	79843	OFF	1	YAL034C-B	complement(79490..79843)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL034W-A	1	79719	80588	ON	1	MTW1	(79719..80588)	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
YAL034C	0	80711	81952	ON	1	FUN19	complement(80711..81952)	Non-essential protein of unknown function
YAL033W	1	82707	83228	ON	1	POP5	(82707..83228)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YAL032C	0	83336	84475	ON	1	PRP45	complement(83336..84475)	Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
YAL031W-A	1	84670	84978	OFF	1	YAL031W-A	(84670..84978)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL031C	0	84750	87032	ON	1	GIP4	complement(84750..87032)	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
YAL030W	1	87287	87753	ON	1	SNC1	(87287..87388,87502..87753)	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YAL029C	0	87856	92271	ON	1	MYO4	complement(87856..92271)	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YAL028W	1	92901	94487	ON	1	FRT2	(92901..94487)	Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YAL027W	1	94688	95473	ON	1	YAL027W	(94688..95473)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YAL027W is a non-essential gene
YAL026C-A	0	95387	95824	OFF	1	YAL026C-A	complement(95387..95824)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2
YAL026C	0	95631	99698	ON	1	DRS2	complement(95631..99698)	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YAL025C	0	100226	101146	ON	1	MAK16	complement(100226..101146)	Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YAL024C	0	101566	105873	ON	1	LTE1	complement(101566..105873)	Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
YAL023C	0	106273	108552	ON	1	PMT2	complement(106273..108552)	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YAL022C	0	108878	110431	ON	1	FUN26	complement(108878..110431)	Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YAL021C	0	110847	113360	ON	1	CCR4	complement(110847..113360)	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YAL020C	0	113615	114616	ON	1	ATS1	complement(113615..114616)	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YAL019W-A	1	114251	114820	OFF	1	YAL019W-A	(114251..114820)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL019W	1	114920	118315	ON	1	FUN30	(114920..118315)	Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL018C	0	118565	119542	ON	1	YAL018C	complement(118565..119542)	Putative protein of unknown function
YAL017W	1	120226	124296	ON	1	PSK1	(120226..124296)	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
YAL016C-B	0	124308	124493	OFF	1	YAL016C-B	complement(124308..124493)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL016C-A	0	124756	125070	OFF	1	YAL016C-A	complement(124756..125070)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL016W	1	124880	126787	ON	1	TPD3	(124880..126787)	Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III
YAL015C	0	126904	128103	ON	1	NTG1	complement(126904..128103)	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
YAL014C	0	128253	129020	ON	1	SYN8	complement(128253..129020)	Endosomal SNARE related to mammalian syntaxin 8
YAL013W	1	129271	130533	ON	1	DEP1	(129271..130533)	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
YAL012W	1	130802	131986	ON	1	CYS3	(130802..131986)	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
YAL011W	1	132202	134079	ON	1	SWC3	(132202..134079)	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
YAL010C	0	134186	135667	ON	1	MDM10	complement(134186..135667)	Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins
YAL009W	1	135856	136635	ON	1	SPO7	(135856..136635)	Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YAL008W	1	136916	137512	ON	1	FUN14	(136916..137512)	Mitochondrial protein of unknown function
YAL007C	0	137700	138347	ON	1	ERP2	complement(137700..138347)	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YAL005C	0	139505	141433	ON	1	SSA1	complement(139505..141433)	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YAL004W	1	140762	141409	OFF	1	YAL004W	(140762..141409)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
YAL003W	1	142176	143162	ON	1	EFB1	(142176..142255,142622..143162)	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YAL002W	1	143709	147533	ON	1	VPS8	(143709..147533)	Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
YAL001C	0	147596	151168	ON	1	TFC3	complement(147596..151008,151099..151168)	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YAR002W	1	152259	153878	ON	1	NUP60	(152259..153878)	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YAR002C-A	0	154067	154726	ON	1	ERP1	complement(154067..154726)	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YAR003W	1	155007	156287	ON	1	SWD1	(155007..156287)	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YAR007C	0	156756	158621	ON	1	RFA1	complement(156756..158621)	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YAR008W	1	158967	159794	ON	1	SEN34	(158967..159794)	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YAR014C	0	166743	168866	ON	1	BUD14	complement(166743..168866)	Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YAR015W	1	169370	170290	ON	1	ADE1	(169370..170290)	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YAR018C	0	170391	171698	ON	1	KIN3	complement(170391..171698)	Nonessential protein kinase with unknown cellular role
YAR019C	0	172209	175133	ON	1	CDC15	complement(172209..175133)	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YAR019W-A	1	174996	175340	OFF	1	YAR019W-A	(174996..175340)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR020C	0	176854	177021	ON	1	PAU7	complement(176854..177021)	Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YAR023C	0	179279	179818	ON	1	YAR023C	complement(179279..179818)	Putative integral membrane protein, member of DUP240 gene family
YAR027W	1	183764	184471	ON	1	UIP3	(183764..184471)	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YAR028W	1	184886	185590	ON	1	YAR028W	(184886..185590)	Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YAR029W	1	186315	186539	ON	1	YAR029W	(186315..186539)	Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YAR030C	0	186506	186847	OFF	1	YAR030C	complement(186506..186847)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
YAR031W	1	186830	187726	ON	1	PRM9	(186830..187726)	Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
YAR033W	1	188101	188805	ON	1	MST28	(188101..188805)	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles
YAR035W	1	190187	192250	ON	1	YAT1	(190187..192250)	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix
YAR035C-A	0	192331	192411	OFF	1	YAR035C-A	complement(192331..192411)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YAR042W	1	192613	196179	ON	1	SWH1	(192613..196179)	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
YAR047C	0	201460	201780	OFF	1	YAR047C	complement(201460..201780)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR050W	1	203394	208007	ON	1	FLO1	(203394..208007)	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YAR053W	1	208358	208654	OFF	1	YAR053W	(208358..208654)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR060C	0	217148	217483	OFF	1	YAR060C	complement(217148..217483)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR061W	1	218131	218334	ON	1	YAR061W	(218131..218334)	Hypothetical protein
YAR062W	1	218540	219136	OFF	1	YAR062W	(218540..219136)	Hypothetical protein
YAR064W	1	220189	220488	ON	1	YAR064W	(220189..220488)	Putative protein of unknown function
YAR066W	1	221040	221651	ON	1	YAR066W	(221040..221651)	Putative GPI protein
YAR068W	1	222397	222882	ON	1	YAR068W	(222397..222882)	Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YAR069C	0	224002	224295	OFF	1	YAR069C	complement(224002..224295)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR070C	0	224554	224853	OFF	1	YAR070C	complement(224554..224853)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR071W	1	225451	226854	ON	1	PHO11	(225451..226854)	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YAR073W	1	227733	228944	ON	1	IMD1	(227733..228944)	Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae
YAR075W	1	228835	229308	ON	1	YAR075W	(228835..229308)	Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae.
YBL113C	0	280	2658	ON	2	YBL113C	complement(280..2658)	Helicase-like protein encoded within the telomeric Y' element
YBL113W-A	1	646	1128	OFF	2	YBL113W-A	(646..1128)	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBL112C	0	2582	2899	ON	2	YBL112C	complement(2582..2899)	Putative protein of unknown function; YBL112C is contained within TEL02L
YBL111C	0	2907	5009	ON	2	YBL111C	complement(2907..4116,4216..5009)	Helicase-like protein encoded within the telomeric Y' element
YBL109W	1	5790	6125	OFF	2	YBL109W	(5790..6125)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBL108C-A	0	7605	7733	ON	2	YBL108C-A	complement(7605..7733)	Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YBL108W	1	8177	8482	OFF	2	YBL108W	(8177..8482)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL107W-A	1	9268	9372	OFF	2	YBL107W-A	(9268..9372)	Similar to TyA and TyB proteins
YBL107C	0	9961	10551	ON	2	YBL107C	complement(9961..10551)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene
YBL106C	0	10847	13879	ON	2	SRO77	complement(10847..13879)	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p
YBL105C	0	14241	17696	ON	2	PKC1	complement(14241..17696)	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YBL104C	0	18177	21293	ON	2	YBL104C	complement(18177..21293)	Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YBL103C	0	22075	23535	ON	2	RTG3	complement(22075..23535)	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YBL102W	1	24098	24745	ON	2	SFT2	(24098..24745)	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YBL101C	0	24946	28299	ON	2	ECM21	complement(24946..28299)	Non-essential protein of unknown function; promoter contains several Gcn4p binding elements
YBL100W-C	1	28427	28546	OFF	2	YBL100W-C	(28427..28546)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBL100C	0	36986	37300	OFF	2	YBL100C	complement(36986..37300)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YBL099W	1	37050	38687	ON	2	ATP1	(37050..38687)	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBL098W	1	39142	40524	ON	2	BNA4	(39142..40524)	Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YBL097W	1	40828	43092	ON	2	BRN1	(40828..43092)	Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics
YBL096C	0	43171	43479	OFF	2	YBL096C	complement(43171..43479)	Non-essential protein of unknown function
YBL095W	1	43274	44086	ON	2	YBL095W	(43274..44086)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL094C	0	43762	44094	OFF	2	YBL094C	complement(43762..44094)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
YBL093C	0	44253	44915	ON	2	ROX3	complement(44253..44915)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
YBL092W	1	45975	46367	ON	2	RPL32	(45975..46367)	Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YBL091C-A	0	46562	47177	ON	2	SCS22	complement(46562..47055,47144..47177)	Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein
YBL091C	0	47360	48625	ON	2	MAP2	complement(47360..48625)	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
YBL090W	1	48822	49355	ON	2	MRP21	(48822..49355)	Mitochondrial ribosomal protein of the large subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YBL089W	1	49571	50950	ON	2	AVT5	(49571..50950)	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YBL088C	0	51016	59379	ON	2	TEL1	complement(51016..59379)	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
YBL087C	0	59818	60735	ON	2	RPL23A	complement(59818..60189,60694..60735)	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins
YBL086C	0	61199	62599	ON	2	YBL086C	complement(61199..62599)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YBL085W	1	63873	66815	ON	2	BOI1	(63873..66815)	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YBL084C	0	67166	69442	ON	2	CDC27	complement(67166..69442)	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YBL083C	0	69710	70135	OFF	2	YBL083C	complement(69710..70135)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
YBL082C	0	69748	71124	ON	2	ALG3	complement(69748..71124)	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YBL081W	1	71863	72969	ON	2	YBL081W	(71863..72969)	Non-essential protein of unknown function
YBL080C	0	73067	74692	ON	2	PET112	complement(73067..74692)	Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog
YBL079W	1	75256	79764	ON	2	NUP170	(75256..79764)	Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p
YBL078C	0	80375	80728	ON	2	ATG8	complement(80375..80728)	Protein required for autophagy; modified by the serial action of Atg4p, Atg7p, and Atg3p, and conjugated at the C terminus with phosphatidylethanolamine, to become the form essential for generation of autophagosomes
YBL077W	1	80895	81326	OFF	2	YBL077W	(80895..81326)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YBL076C	0	81041	84259	ON	2	ILS1	complement(81041..84259)	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YBL075C	0	84497	86446	ON	2	SSA3	complement(84497..86446)	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YBL074C	0	86720	87787	ON	2	AAR2	complement(86720..87787)	Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
YBL073W	1	87644	87955	OFF	2	YBL073W	(87644..87955)	Hypothetical protein; open reading frame overlaps 5' end of essential AAR2 gene encoding a component of the U5 snRNP required for splicing of U3 precursors
YBL072C	0	88521	89123	ON	2	RPS8A	complement(88521..89123)	Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YBL071C-B	0	89456	89554	OFF	2	YBL071C-B	complement(89456..89554)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBL071W-A	1	89976	90224	ON	2	KTI11	(89976..90224)	Protein required for synthesis of diphthamide, a modified histidine residue of translation elongation factor 2; functions with Dph1p, Dph2p, Jjj3p, and Dph5p; required, with Elongator complex, for modification of wobble nucleosides in tRNA
YBL071C	0	90221	90529	OFF	2	YBL071C	complement(90221..90529)	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
YBL070C	0	90603	90923	OFF	2	YBL070C	complement(90603..90923)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL069W	1	90739	92028	ON	2	AST1	(90739..92028)	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YBL068W-A	1	91792	92028	OFF	2	YBL068W-A	(91792..92028)	Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR
YBL068W	1	92412	93395	ON	2	PRS4	(92412..93395)	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YBL067C	0	93641	95884	ON	2	UBP13	complement(93641..95884)	Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YBL066C	0	96671	100117	ON	2	SEF1	complement(96671..100117)	Putative transcription factor, has homolog in Kluyveromyces lactis
YBL065W	1	99965	100309	OFF	2	YBL065W	(99965..100309)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
YBL064C	0	100373	101158	ON	2	PRX1	complement(100373..101158)	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress
YBL063W	1	101888	105223	ON	2	KIP1	(101888..105223)	Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YBL062W	1	105310	105690	OFF	2	YBL062W	(105310..105690)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL061C	0	105318	107408	ON	2	SKT5	complement(105318..107408)	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation
YBL060W	1	107934	109997	ON	2	YBL060W	(107934..109997)	Non-essential protein proposed to be a nucleotide exchange factor for Arf3
YBL059C-A	0	110127	110541	ON	2	YBL059C-A	complement(110127..110422,110508..110541)	Putative protein of unknown function; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBL059W	1	110596	111246	ON	2	YBL059W	(110596..110881,110951..111246)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL058W	1	111439	112710	ON	2	SHP1	(111439..112710)	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
YBL057C	0	112803	113447	ON	2	PTH2	complement(112803..113447)	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
YBL056W	1	113765	115171	ON	2	PTC3	(113765..115171)	Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA checkpoint inactivation
YBL055C	0	115576	116832	ON	2	YBL055C	complement(115576..116832)	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YBL054W	1	117592	119169	ON	2	YBL054W	(117592..119169)	Protein of unknown function involved in rRNA and ribosome biosynthesis
YBL053W	1	119338	119712	OFF	2	YBL053W	(119338..119712)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL052C	0	119382	121877	ON	2	SAS3	complement(119382..121877)	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YBL051C	0	122756	124762	ON	2	PIN4	complement(122756..124762)	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
YBL050W	1	125128	126122	ON	2	SEC17	(125128..125157,125274..126122)	Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP
YBL049W	1	126831	127247	ON	2	MOH1	(126831..127247)	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YBL048W	1	127302	127613	OFF	2	YBL048W	(127302..127613)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBL047C	0	127898	132043	ON	2	EDE1	complement(127898..132043)	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
YBL046W	1	132427	133752	ON	2	PSY4	(132427..133752)	Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YBL045C	0	134146	135519	ON	2	COR1	complement(134146..135519)	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YBL044W	1	136001	136369	OFF	2	YBL044W	(136001..136369)	Putative protein of unknown function; YBL044W is not an essential protein
YBL043W	1	136691	137464	ON	2	ECM13	(136691..137464)	Non-essential protein of unknown function
YBL042C	0	138344	140263	ON	2	FUI1	complement(138344..140263)	High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport
YBL041W	1	141250	141975	ON	2	PRE7	(141250..141975)	20S proteasome beta-type subunit
YBL040C	0	142115	142871	ON	2	ERD2	complement(142115..142752,142850..142871)	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YBL039W-B	1	143396	143575	ON	2	YBL039W-B	(143396..143575)	Putative protein of unknown function
YBL039C	0	143992	145731	ON	2	URA7	complement(143992..145731)	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YBL039C-A	0	144951	145034	OFF	2	YBL039C-A	complement(144951..145034)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry
YBL038W	1	146190	146888	ON	2	MRPL16	(146190..146888)	Mitochondrial ribosomal protein of the large subunit
YBL037W	1	147212	150289	ON	2	APL3	(147212..150289)	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
YBL036C	0	150450	151223	ON	2	YBL036C	complement(150450..151223)	Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YBL035C	0	151496	153613	ON	2	POL12	complement(151496..153613)	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
YBL034C	0	153851	158392	ON	2	STU1	complement(153851..158392)	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
YBL033C	0	158659	159696	ON	2	RIB1	complement(158659..159696)	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YBL032W	1	160187	161332	ON	2	HEK2	(160187..161332)	RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YBL031W	1	161702	162718	ON	2	SHE1	(161702..162718)	Cytoskeletal protein of unknown function; overexpression causes growth arrest
YBL030C	0	163044	164000	ON	2	PET9	complement(163044..164000)	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YBL029C-A	0	164491	164775	ON	2	YBL029C-A	complement(164491..164775)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YBL029W	1	166137	167267	ON	2	YBL029W	(166137..167267)	Non-essential protein of unknown function
YBL028C	0	167521	167841	ON	2	YBL028C	complement(167521..167841)	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YBL027W	1	168426	169379	ON	2	RPL19B	(168426..168427,168812..169379)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YBL026W	1	170626	171041	ON	2	LSM2	(170626..170679,170808..171041)	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YBL025W	1	171484	171921	ON	2	RRN10	(171484..171921)	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YBL024W	1	172537	174591	ON	2	NCL1	(172537..174591)	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YBL023C	0	174923	177529	ON	2	MCM2	complement(174923..177529)	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBL022C	0	177877	181278	ON	2	PIM1	complement(177877..181278)	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
YBL021C	0	181663	182097	ON	2	HAP3	complement(181663..182097)	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
YBL020W	1	182404	184128	ON	2	RFT1	(182404..184128)	Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein
YBL019W	1	184356	185918	ON	2	APN2	(184356..185918)	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
YBL018C	0	186001	186477	ON	2	POP8	complement(186001..186355,186431..186477)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YBL017C	0	186847	191586	ON	2	PEP1	complement(186847..191586)	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YBL016W	1	192454	193515	ON	2	FUS3	(192454..193515)	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivatd by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YBL015W	1	194125	195705	ON	2	ACH1	(194125..195705)	Acetyl-coA hydrolase, primarily localized to mitochondria; required for acetate utilization and for diploid pseudohyphal growth
YBL014C	0	199067	201751	ON	2	RRN6	complement(199067..201751)	Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein
YBL013W	1	202059	203264	ON	2	FMT1	(202059..203264)	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
YBL012C	0	203409	203810	OFF	2	YBL012C	complement(203409..203810)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL011W	1	203541	205820	ON	2	SCT1	(203541..205820)	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YBL010C	0	206110	206952	ON	2	YBL010C	complement(206110..206952)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
YBL009W	1	207197	209227	ON	2	ALK2	(207197..209227)	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YBL008W-A	1	209412	209651	OFF	2	YBL008W-A	(209412..209651)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YBL008W	1	209656	212178	ON	2	HIR1	(209656..212178)	Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
YBL007C	0	212635	216369	ON	2	SLA1	complement(212635..216369)	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis
YBL006C	0	216590	217132	ON	2	LDB7	complement(216590..217132)	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YBL006W-A	1	216714	216863	OFF	2	YBL006W-A	(216714..216863)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C
YBL005W	1	217473	220403	ON	2	PDR3	(217473..220403)	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
YBL004W	1	227639	235120	ON	2	UTP20	(227639..235120)	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YBL003C	0	235397	235795	ON	2	HTA2	complement(235397..235795)	One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YBL002W	1	236495	236890	ON	2	HTB2	(236495..236890)	One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YBL001C	0	237155	237469	ON	2	ECM15	complement(237155..237469)	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YBR001C	0	238943	241285	ON	2	NTH2	complement(238943..241285)	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YBR002C	0	241710	242570	ON	2	RER2	complement(241710..242570)	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
YBR003W	1	242811	244232	ON	2	COQ1	(242811..244232)	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
YBR004C	0	244368	245669	ON	2	GPI18	complement(244368..245669)	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YBR005W	1	245908	246549	ON	2	RCR1	(245908..246549)	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane
YBR006W	1	247012	248505	ON	2	UGA2	(247012..248505)	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YBR007C	0	248807	251017	ON	2	DSF2	complement(248807..251017)	Deletion suppressor of mpt5 mutation
YBR008C	0	252564	254210	ON	2	FLR1	complement(252564..254210)	Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YBR009C	0	255371	255682	ON	2	HHF1	complement(255371..255682)	One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YBR010W	1	256329	256739	ON	2	HHT1	(256329..256739)	One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YBR011C	0	257110	257973	ON	2	IPP1	complement(257110..257973)	Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
Scer_YGOB_YBR013C-YBR012C	0	259145	265879	ON	2	YBR013C-YBR012C	complement(259145..259575,265498..265879)	ANNOTATED BY YGOB - Gene is interrupted by a Ty element in S288c but not YJM789.
YBR012C	0	259145	259564	OFF	2	YBR012C	complement(259145..259564)	Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YBR013C	0	265490	265879	OFF	2	YBR013C	complement(265490..265879)	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YBR014C	0	266725	267336	ON	2	YBR014C	complement(266725..267336)	Putative membrane-localized protein of unknown function, contains glutaredoxin domain
YBR015C	0	267710	269503	ON	2	MNN2	complement(267710..269503)	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YBR016W	1	270247	270633	ON	2	YBR016W	(270247..270633)	Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions
YBR017C	0	270947	273703	ON	2	KAP104	complement(270947..273703)	Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YBR018C	0	274427	275527	ON	2	GAL7	complement(274427..275527)	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YBR019C	0	276253	278352	ON	2	GAL10	complement(276253..278352)	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YBR020W	1	279021	280607	ON	2	GAL1	(279021..280607)	Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YBR021W	1	281443	283344	ON	2	FUR4	(281443..283344)	Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YBR022W	1	283738	284271	ON	2	POA1	(283738..284271)	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YBR023C	0	284428	287925	ON	2	CHS3	complement(284428..287925)	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YBR024W	1	289445	290350	ON	2	SCO2	(289445..290350)	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YBR025C	0	290681	291865	ON	2	OLA1	complement(290681..291865)	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide
YBR026C	0	292877	294019	ON	2	ETR1	complement(292877..294019)	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
YBR027C	0	294024	294356	OFF	2	YBR027C	complement(294024..294356)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR028C	0	294425	296002	ON	2	YBR028C	complement(294425..296002)	Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YBR029C	0	296369	297742	ON	2	CDS1	complement(296369..297742)	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YBR030W	1	298292	299950	ON	2	YBR030W	(298292..299950)	Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YBR031W	1	300166	301254	ON	2	RPL4A	(300166..301254)	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins
YBR032W	1	301519	301821	OFF	2	YBR032W	(301519..301821)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YBR033W	1	301944	304703	ON	2	EDS1	(301944..304703)	Putative zinc cluster protein; YBR033W is not an essential gene
YBR034C	0	304930	305976	ON	2	HMT1	complement(304930..305976)	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
YBR035C	0	306269	306955	ON	2	PDX3	complement(306269..306955)	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YBR036C	0	309081	310313	ON	2	CSG2	complement(309081..310313)	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
YBR037C	0	310564	311451	ON	2	SCO1	complement(310564..311451)	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
YBR038W	1	311897	314788	ON	2	CHS2	(311897..314788)	Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis
YBR039W	1	315575	316510	ON	2	ATP3	(315575..316510)	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YBR040W	1	316968	317864	ON	2	FIG1	(316968..317864)	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YBR041W	1	318266	320275	ON	2	FAT1	(318266..320275)	Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
YBR042C	0	320416	321609	ON	2	CST26	complement(320416..321609)	Protein of unknown function, affects chromosome stability when overexpressed
YBR043C	0	321876	323945	ON	2	QDR3	complement(321876..323945)	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin
YBR044C	0	324337	326058	ON	2	TCM62	complement(324337..326058)	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YBR045C	0	328369	330090	ON	2	GIP1	complement(328369..330090)	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YBR046C	0	330505	331509	ON	2	ZTA1	complement(330505..331509)	Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
YBR047W	1	331831	332358	ON	2	YBR047W	(331831..332358)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR048W	1	332829	333810	ON	2	RPS11B	(332829..332873,333385..333810)	Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YBR049C	0	334384	336816	ON	2	REB1	complement(334384..336816)	RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YBR050C	0	337181	338197	ON	2	REG2	complement(337181..338197)	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YBR051W	1	337986	338336	OFF	2	YBR051W	(337986..338336)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YBR052C	0	338718	339350	ON	2	RFS1	complement(338718..339350)	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR053C	0	339673	340749	ON	2	YBR053C	complement(339673..340749)	Putative protein of unknown function; induced by cell wall perturbation
YBR054W	1	343099	344133	ON	2	YRO2	(343099..344133)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YBR055C	0	344600	347299	ON	2	PRP6	complement(344600..347299)	Splicing factor, component of the U4/U6-U5 snRNP complex
YBR056W	1	347877	349382	ON	2	YBR056W	(347877..349382)	Putative cytoplasmic protein of unknown function
YBR056W-A	1	351253	351453	ON	2	YBR056W-A	(351253..351453)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YBR056C-B	0	351291	351449	OFF	2	YBR056C-B	complement(351291..351449)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A
YBR057C	0	352191	353291	ON	2	MUM2	complement(352191..353291)	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
YBR058C	0	353670	356015	ON	2	UBP14	complement(353670..356015)	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
YBR058C-A	0	356322	356564	ON	2	TSC3	complement(356322..356564)	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YBR059C	0	356859	360185	ON	2	AKL1	complement(356859..360185)	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
YBR060C	0	360650	362512	ON	2	ORC2	complement(360650..362512)	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p
YBR061C	0	364785	365717	ON	2	TRM7	complement(364785..365717)	2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YBR062C	0	365974	366598	ON	2	YBR062C	complement(365974..366500,366583..366598)	Hypothetical protein
YBR063C	0	366968	368182	ON	2	YBR063C	complement(366968..368182)	Putative protein of unknown function; YBR063C is not an essential gene
YBR064W	1	367761	368189	OFF	2	YBR064W	(367761..368189)	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C
YBR065C	0	368582	369676	ON	2	ECM2	complement(368582..369676)	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
YBR066C	0	370035	370697	ON	2	NRG2	complement(370035..370697)	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YBR067C	0	372100	372732	ON	2	TIP1	complement(372100..372732)	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YBR068C	0	373858	375687	ON	2	BAP2	complement(373858..375687)	High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YBR069C	0	376571	378430	ON	2	TAT1	complement(376571..378430)	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 resistance
YBR070C	0	379218	379931	ON	2	ALG14	complement(379218..379931)	Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
YBR071W	1	380408	381043	ON	2	YBR071W	(380408..381043)	Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress
YBR072W	1	382027	382671	ON	2	HSP26	(382027..382671)	Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YBR072C-A	0	382855	383016	OFF	2	YBR072C-A	complement(382855..383016)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YBR073W	1	383209	385983	ON	2	RDH54	(383209..385983)	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during mitosis and meiosis; proposed to be involved in crossover interference
YBR074W	1	386281	389211	ON	2	YBR074W	(386281..389211)	Putative metalloprotease
YBR076W	1	390369	391388	ON	2	ECM8	(390369..391388)	Non-essential protein of unknown function
YBR076C-A	0	391345	391611	OFF	2	YBR076C-A	complement(391345..391611)	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YBR077C	0	391799	392287	ON	2	SLM4	complement(391799..392287)	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YBR078W	1	393118	394854	ON	2	ECM33	(393118..393175,393506..394854)	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; similar to Sps2p and Pst1p
YBR079C	0	395377	398271	ON	2	RPG1	complement(395377..398271)	Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YBR080C	0	398608	400884	ON	2	SEC18	complement(398608..400884)	ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
YBR081C	0	401247	405245	ON	2	SPT7	complement(401247..405245)	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YBR082C	0	406622	407163	ON	2	UBC4	complement(406622..407021,407117..407163)	Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YBR083W	1	409163	410623	ON	2	TEC1	(409163..410623)	Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YBR084W	1	411048	413975	ON	2	MIS1	(411048..413975)	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
YBR084C-A	0	414180	415255	ON	2	RPL19A	complement(414180..414747,415254..415255)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YBR085W	1	415977	416900	ON	2	AAC3	(415977..416900)	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YBR085C-A	0	418901	419158	ON	2	YBR085C-A	complement(418901..419158)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YBR086C	0	420195	423035	ON	2	IST2	complement(420195..423035)	Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
YBR087W	1	423759	424823	ON	2	RFC5	(423759..424823)	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YBR088C	0	424984	425760	ON	2	POL30	complement(424984..425760)	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YBR089W	1	425177	425776	OFF	2	YBR089W	(425177..425776)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
YBR089C-A	0	426184	426483	ON	2	NHP6B	complement(426184..426483)	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YBR090C	0	426327	427052	OFF	2	YBR090C	complement(426327..426510,426868..427052)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBR091C	0	427149	427478	ON	2	MRS5	complement(427149..427478)	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
YBR092C	0	427692	429095	ON	2	PHO3	complement(427692..429095)	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YBR093C	0	429542	430945	ON	2	PHO5	complement(429542..430945)	Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YBR094W	1	432030	434291	ON	2	PBY1	(432030..434291)	Putative tubulin tyrosine ligase associated with P-bodies
YBR095C	0	434400	435692	ON	2	RXT2	complement(434400..435692)	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
YBR096W	1	436015	436707	ON	2	YBR096W	(436015..436707)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YBR097W	1	436945	441309	ON	2	VPS15	(436945..441309)	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p
YBR098W	1	441509	443584	ON	2	MMS4	(441509..443584)	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair
YBR099C	0	442918	443301	OFF	2	YBR099C	complement(442918..443301)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
YBR101C	0	443815	444687	ON	2	FES1	complement(443815..444687)	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YBR102C	0	445056	447317	ON	2	EXO84	complement(445056..447317)	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
YBR103W	1	447703	449310	ON	2	SIF2	(447703..449310)	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
YBR103C-A	0	449314	449457	OFF	2	YBR103C-A	complement(449314..449457)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; identified by homology to related yeast
YBR104W	1	449661	450650	ON	2	YMC2	(449661..450650)	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YBR105C	0	450875	451963	ON	2	VID24	complement(450875..451963)	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YBR106W	1	452652	453218	ON	2	PHO88	(452652..453218)	Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YBR107C	0	453787	454524	ON	2	IML3	complement(453787..454524)	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
YBR108W	1	454816	457659	ON	2	YBR108W	(454816..457659)	Protein interacting with Rsv167p
YBR109C	0	457913	458356	ON	2	CMD1	complement(457913..458356)	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
YBR109W-A	1	458602	458826	OFF	2	YBR109W-A	(458602..458826)	Putative protein of unknown function; questionable ORF from MIPS
YBR110W	1	458866	460215	ON	2	ALG1	(458866..460215)	Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
YBR111C	0	461172	461867	ON	2	YSA1	complement(461172..461867)	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity
YBR111W-A	1	462133	462573	ON	2	SUS1	(462133..462203,462284..462423,462494..462573)	Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
YBR112C	0	462864	465764	ON	2	CYC8	complement(462864..465764)	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YBR113W	1	465560	466042	OFF	2	YBR113W	(465560..466042)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YBR114W	1	467242	469614	ON	2	RAD16	(467242..469614)	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YBR115C	0	469742	473920	ON	2	LYS2	complement(469742..473920)	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
YBR116C	0	474193	474720	OFF	2	YBR116C	complement(474193..474720)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YBR117C	0	474386	476431	ON	2	TKL2	complement(474386..476431)	Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YBR118W	1	477665	479041	ON	2	TEF2	(477665..479041)	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YBR119W	1	479332	480317	ON	2	MUD1	(479332..479339,479429..480317)	U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
YBR120C	0	480429	480917	ON	2	CBP6	complement(480429..480917)	Mitochondrial translational activator of the COB mRNA
YBR121C	0	481358	483361	ON	2	GRS1	complement(481358..483361)	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YBR121C-A	0	482320	482478	OFF	2	YBR121C-A	complement(482320..482478)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely contianed within the verified gene GRS1; identified by expression profiling and mass spectrometry
YBR122C	0	483964	484497	ON	2	MRPL36	complement(483964..484497)	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region
YBR123C	0	484736	486685	ON	2	TFC1	complement(484736..486685)	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63
YBR124W	1	486501	486860	OFF	2	YBR124W	(486501..486860)	Putative protein of unknown function
YBR125C	0	487193	488374	ON	2	PTC4	complement(487193..488374)	Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YBR126C	0	488899	490386	ON	2	TPS1	complement(488899..490386)	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YBR126W-A	1	490844	491050	OFF	2	YBR126W-A	(490844..491050)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YBR126W-B	1	490921	491064	OFF	2	YBR126W-B	(490921..491064)	Identified by SAGE
YBR127C	0	491263	492816	ON	2	VMA2	complement(491263..492816)	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
YBR128C	0	493075	494109	ON	2	ATG14	complement(493075..494109)	Subunit of an autophagy-specific phosphatidylinositol 3-kinase complex (with Vps34p, Vps15p, and Vps30p) required for organization of a pre-autophagosomal structure; ATG14 transcription is activated by Gln3p during nitrogen starvation
YBR129C	0	494347	495333	ON	2	OPY1	complement(494347..495333)	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR130C	0	495586	496863	ON	2	SHE3	complement(495586..496863)	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YBR131W	1	497157	499271	ON	2	CCZ1	(497157..499271)	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
YBR131C-A	0	497644	497733	OFF	2	YBR131C-A	complement(497644..497733)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W. Identified by gene-trapping, microarray analysis, and genome-wide homology searches
YBR132C	0	499646	501436	ON	2	AGP2	complement(499646..501436)	High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YBR133C	0	501798	504281	ON	2	HSL7	complement(501798..504281)	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YBR134W	1	504237	504638	OFF	2	YBR134W	(504237..504638)	Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR135W	1	504848	505300	ON	2	CKS1	(504848..505300)	Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
YBR136W	1	505662	512768	ON	2	MEC1	(505662..512768)	Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
YBR137W	1	513038	513577	ON	2	YBR137W	(513038..513577)	Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YBR138C	0	513756	515330	ON	2	YBR138C	complement(513756..515330)	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
YBR139W	1	515658	517184	ON	2	YBR139W	(515658..517184)	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
YBR140C	0	517344	526622	ON	2	IRA1	complement(517344..526622)	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
YBR141C	0	527019	528032	ON	2	YBR141C	complement(527019..528032)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene
YBR141W-A	1	527161	527256	OFF	2	YBR141W-A	(527161..527256)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching
YBR142W	1	528311	530632	ON	2	MAK5	(528311..530632)	Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YBR143C	0	530863	532176	ON	2	SUP45	complement(530863..532176)	Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YBR144C	0	533229	533543	OFF	2	YBR144C	complement(533229..533543)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
YBR145W	1	533756	534811	ON	2	ADH5	(533756..534811)	Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YBR146W	1	535254	536090	ON	2	MRPS9	(535254..536090)	Mitochondrial ribosomal protein of the small subunit
YBR147W	1	536569	537459	ON	2	YBR147W	(536569..537459)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance
YBR148W	1	537870	539699	ON	2	YSW1	(537870..539699)	Protein expressed specifically in spores
YBR149W	1	539981	541015	ON	2	ARA1	(539981..541015)	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YBR150C	0	541203	544487	ON	2	TBS1	complement(541203..544487)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR151W	1	545022	545972	ON	2	APD1	(545022..545972)	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
YBR152W	1	546370	547245	ON	2	SPP381	(546370..547245)	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
YBR153W	1	547454	548188	ON	2	RIB7	(547454..548188)	Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YBR154C	0	548356	549003	ON	2	RPB5	complement(548356..549003)	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YBR155W	1	549765	550922	ON	2	CNS1	(549765..550922)	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
YBR156C	0	551098	553194	ON	2	SLI15	complement(551098..553194)	Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase
YBR157C	0	553537	554304	ON	2	ICS2	complement(553537..554304)	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YBR158W	1	556543	558192	ON	2	AMN1	(556543..558192)	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YBR159W	1	558679	559722	ON	2	YBR159W	(558679..559722)	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
YBR160W	1	560072	560968	ON	2	CDC28	(560072..560968)	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
YBR161W	1	561629	562759	ON	2	CSH1	(561629..562759)	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p
YBR162C	0	563198	564565	ON	2	TOS1	complement(563198..564565)	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YBR162W-A	1	565226	565423	ON	2	YSY6	(565226..565423)	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
YBR163W	1	565718	567475	ON	2	DEM1	(565718..567475)	Protein of unknown function, shows similarity to RNA-processing protein Pta1p
YBR164C	0	567870	568421	ON	2	ARL1	complement(567870..568421)	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YBR165W	1	568847	569680	ON	2	UBS1	(568847..569680)	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
YBR166C	0	569837	571195	ON	2	TYR1	complement(569837..571195)	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
YBR167C	0	571463	571885	ON	2	POP7	complement(571463..571885)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YBR168W	1	572366	573607	ON	2	PEX32	(572366..573607)	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YBR169C	0	573910	575991	ON	2	SSE2	complement(573910..575991)	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YBR170C	0	576339	578081	ON	2	NPL4	complement(576339..578081)	Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation
YBR171W	1	578359	578979	ON	2	SEC66	(578359..578979)	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YBR172C	0	579145	581367	ON	2	SMY2	complement(579145..581367)	Protein of unknown function that interacts with Myo2p; has similarity to S. pombe Mpd2
YBR173C	0	581721	582167	ON	2	UMP1	complement(581721..582167)	Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
YBR174C	0	582333	582647	OFF	2	YBR174C	complement(582333..582647)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective
YBR175W	1	582403	583350	ON	2	SWD3	(582403..583350)	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
YBR176W	1	583715	584653	ON	2	ECM31	(583715..584653)	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
YBR177C	0	584802	586157	ON	2	EHT1	complement(584802..586157)	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; contains esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YBR178W	1	586066	586440	OFF	2	YBR178W	(586066..586440)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YBR179C	0	586542	589109	ON	2	FZO1	complement(586542..589109)	Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YBR180W	1	589736	591454	ON	2	DTR1	(589736..591454)	Multidrug resistance dityrosine transporter of the major facilitator superfamily, essential for spore wall synthesis, facilitates the translocation of bisformyl dityrosine through the prospore membrane
YBR181C	0	591707	592769	ON	2	RPS6B	complement(591707..592411,592764..592769)	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YBR182C	0	593501	594859	ON	2	SMP1	complement(593501..594859)	Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YBR182C-A	0	595356	595550	OFF	2	YBR182C-A	complement(595356..595550)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR183W	1	596110	597060	ON	2	YPC1	(596110..597060)	Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YBR184W	1	597358	598929	ON	2	YBR184W	(597358..598929)	Putative protein of unknown function; YBR184W is not an essential gene
YBR185C	0	599118	599954	ON	2	MBA1	complement(599118..599954)	Protein involved in assembly of mitochondrial respiratory complexes; may act as a receptor for proteins destined for export from the mitochondrial matrix to the inner membrane
YBR186W	1	600548	602355	ON	2	PCH2	(600548..602098,602212..602355)	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA
YBR187W	1	602629	603471	ON	2	GDT1	(602629..603471)	Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
YBR188C	0	603680	604102	ON	2	NTC20	complement(603680..604102)	Member of a complex, including Prp19p, that binds to the spliceosome; required for pre-mRNA splicing
YBR189W	1	604503	605503	ON	2	RPS9B	(604503..604509,604923..605503)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YBR190W	1	605961	606272	OFF	2	YBR190W	(605961..606272)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
YBR191W	1	606265	607135	ON	2	RPL21A	(606265..606275,606664..607135)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
YBR191W-A	1	607144	607218	OFF	2	YBR191W-A	(607144..607218)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR192W	1	607647	608780	ON	2	RIM2	(607647..608780)	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YBR193C	0	609077	609748	ON	2	MED8	complement(609077..609748)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YBR194W	1	610033	610404	ON	2	YBR194W	(610033..610404)	Protein proposed to be associated with the nuclear pore complex
YBR195C	0	610609	611877	ON	2	MSI1	complement(610609..611877)	Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
YBR196C	0	612231	613895	ON	2	PGI1	complement(612231..613895)	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
YBR196C-A	0	614019	614168	OFF	2	YBR196C-A	complement(614019..614168)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YBR196C-B	0	614521	614625	OFF	2	YBR196C-B	complement(614521..614625)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YBR197C	0	615198	615851	ON	2	YBR197C	complement(615198..615851)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene
YBR198C	0	616122	618518	ON	2	TAF5	complement(616122..618518)	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YBR199W	1	618904	620298	ON	2	KTR4	(618904..620298)	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YBR200W	1	620867	622522	ON	2	BEM1	(620867..622522)	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
YBR200W-A	1	622978	623142	OFF	2	YBR200W-A	(622978..623142)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YBR201W	1	623572	624207	ON	2	DER1	(623572..624207)	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YBR201C-A	0	624489	624692	ON	2	YBR201C-A	complement(624489..624692)	Putative protein of unknown function
YBR202W	1	625767	628304	ON	2	CDC47	(625767..628304)	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YBR203W	1	629163	631937	ON	2	COS111	(629163..631937)	Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR204C	0	632249	633376	ON	2	YBR204C	complement(632249..633376)	Serine hydrolase; YBR204C is not an essential gene
YBR205W	1	633617	634831	ON	2	KTR3	(633617..634831)	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YBR206W	1	634596	634919	OFF	2	YBR206W	(634596..634919)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
YBR207W	1	635141	636538	ON	2	FTH1	(635141..636538)	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
YBR208C	0	636698	642205	ON	2	DUR1,2	complement(636698..642205)	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YBR209W	1	642578	642895	OFF	2	YBR209W	(642578..642895)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YBR210W	1	645545	645973	ON	2	ERV15	(645545..645973)	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YBR211C	0	646153	647127	ON	2	AME1	complement(646153..647127)	Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
YBR212W	1	647881	649899	ON	2	NGR1	(647881..649899)	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
YBR213W	1	650363	651187	ON	2	MET8	(650363..651187)	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YBR214W	1	651410	652993	ON	2	SDS24	(651410..652993)	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YBR215W	1	653351	655312	ON	2	HPC2	(653351..653363,653448..655312)	Highly charged, basic protein required for normal cell-cycle regulation of histone gene transcription; mutants display strong synthetic defects with subunits of FACT, a complex that allows RNA Pol II to elongate through nucleosomes
YBR216C	0	655571	657595	ON	2	YBP1	complement(655571..657595)	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
YBR217W	1	657827	658387	ON	2	ATG12	(657827..658387)	Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy
YBR218C	0	658702	662244	ON	2	PYC2	complement(658702..662244)	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YBR219C	0	662494	663298	OFF	2	YBR219C	complement(662494..662576,662998..663298)	Putative protein of unknown function; YBR219C is not an essential gene
YBR220C	0	662990	664672	ON	2	YBR220C	complement(662990..664672)	Putative protein of unknown function; YBR220C is not an essential gene
YBR221C	0	665148	666248	ON	2	PDB1	complement(665148..666248)	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
YBR221W-A	1	666533	666637	OFF	2	YBR221W-A	(666533..666637)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YBR222C	0	666715	668346	ON	2	PCS60	complement(666715..668346)	Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase
YBR223C	0	668658	670292	ON	2	TDP1	complement(668658..670292)	Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3'-phosphotyrosyl bonds to generate 3'-phosphate DNA and tyrosine, involved in the repair of DNA lesions created by topoisomerase I
YBR223W-A	1	668716	668835	OFF	2	YBR223W-A	(668716..668835)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR224W	1	670120	670635	OFF	2	YBR224W	(670120..670635)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
YBR225W	1	670622	673324	ON	2	YBR225W	(670622..673324)	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
YBR226C	0	673150	673560	OFF	2	YBR226C	complement(673150..673560)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W
YBR227C	0	673567	675129	ON	2	MCX1	complement(673567..675129)	Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YBR228W	1	675308	676222	ON	2	SLX1	(675308..676222)	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YBR229C	0	676352	679216	ON	2	ROT2	complement(676352..679216)	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
YBR230C	0	679544	680045	ON	2	OM14	complement(679544..679937,680035..680045)	Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YBR230W-A	1	680357	680557	OFF	2	YBR230W-A	(680357..680557)	Putative protein of unknown function
YBR231C	0	682174	683085	ON	2	SWC5	complement(682174..683085)	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YBR232C	0	683368	683727	OFF	2	YBR232C	complement(683368..683727)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR233W	1	683423	684664	ON	2	PBP2	(683423..684664)	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YBR233W-A	1	684972	685256	ON	2	DAD3	(684972..685256)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YBR234C	0	685433	686587	ON	2	ARC40	complement(685433..686587)	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YBR235W	1	686896	690258	ON	2	YBR235W	(686896..690258)	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YBR236C	0	690378	691688	ON	2	ABD1	complement(690378..691688)	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YBR237W	1	691964	694513	ON	2	PRP5	(691964..694513)	RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
YBR238C	0	695102	697297	ON	2	YBR238C	complement(695102..697297)	Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YBR239C	0	698349	699938	ON	2	YBR239C	complement(698349..699938)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene
YBR240C	0	700485	701837	ON	2	THI2	complement(700485..701837)	Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YBR241C	0	702584	704050	ON	2	YBR241C	complement(702584..704050)	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YBR242W	1	704665	705381	ON	2	YBR242W	(704665..705381)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YBR243C	0	705442	706788	ON	2	ALG7	complement(705442..706788)	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YBR244W	1	707523	708011	ON	2	GPX2	(707523..708011)	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YBR245C	0	708145	711534	ON	2	ISW1	complement(708145..711534)	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
YBR246W	1	711586	712749	ON	2	YBR246W	(711586..712749)	Putative protein of unknown function; deletion results in a weak carboxypeptidase Y missorting/secretion phenotype; YBR246W is not an essential gene
YBR247C	0	712999	714450	ON	2	ENP1	complement(712999..714450)	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YBR248C	0	714802	716460	ON	2	HIS7	complement(714802..716460)	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
YBR249C	0	716877	717989	ON	2	ARO4	complement(716877..717989)	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YBR250W	1	719028	720599	ON	2	SPO23	(719028..720599)	Protein of unknown function; associates with meiosis-specific protein Spo1p
YBR251W	1	721385	722308	ON	2	MRPS5	(721385..722308)	Mitochondrial ribosomal protein of the small subunit
YBR252W	1	722606	723049	ON	2	DUT1	(722606..723049)	dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YBR253W	1	723265	723630	ON	2	SRB6	(723265..723630)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YBR254C	0	723731	724258	ON	2	TRS20	complement(723731..724258)	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YBR255W	1	724451	726535	ON	2	YBR255W	(724451..726535)	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR255C-A	0	726613	727069	ON	2	YBR255C-A	complement(726613..726912,727007..727069)	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YBR256C	0	727381	728097	ON	2	RIB5	complement(727381..728097)	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YBR257W	1	728880	729719	ON	2	POP4	(728880..729719)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YBR258C	0	729729	730157	ON	2	SHG1	complement(729729..730157)	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
YBR259W	1	730382	732448	ON	2	YBR259W	(730382..732448)	Putative protein of unknown function; YBR259W is not an essential gene
YBR260C	0	732634	734634	ON	2	RGD1	complement(732634..734634)	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
YBR261C	0	734827	735525	ON	2	YBR261C	complement(734827..735525)	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential gene
YBR262C	0	735715	736035	ON	2	YBR262C	complement(735715..736035)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR263W	1	736259	737731	ON	2	SHM1	(736259..737731)	Mitochondrial serine hydroxymethyltransferase, involved in one-carbon metabolism
YBR264C	0	737765	738364	ON	2	YPT10	complement(737765..738364)	GTP binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
YBR265W	1	738577	739539	ON	2	TSC10	(738577..739539)	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
YBR267W	1	739836	741017	ON	2	REI1	(739836..741017)	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YBR266C	0	739931	740383	OFF	2	SLM6	complement(739931..740383)	Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase
YBR268W	1	741294	741611	ON	2	MRPL37	(741294..741611)	Mitochondrial ribosomal protein of the large subunit
YBR269C	0	742155	742571	ON	2	YBR269C	complement(742155..742571)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR270C	0	742756	744393	ON	2	YBR270C	complement(742756..744393)	Hypothetical protein
YBR271W	1	744847	746106	ON	2	YBR271W	(744847..746106)	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YBR272C	0	746356	747798	ON	2	HSM3	complement(746356..747798)	Protein of unknown function, involved in DNA mismatch repair during slow growth; has weak similarity to Msh1p
YBR273C	0	748056	749366	ON	2	UBX7	complement(748056..749366)	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YBR274W	1	749589	751172	ON	2	CHK1	(749589..751172)	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
YBR275C	0	751351	757101	ON	2	RIF1	complement(751351..757101)	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YBR276C	0	757616	760039	ON	2	PPS1	complement(757616..760039)	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
YBR277C	0	760211	760612	OFF	2	YBR277C	complement(760211..760612)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W
YBR278W	1	760290	760895	ON	2	DPB3	(760290..760895)	Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
YBR279W	1	761253	762590	ON	2	PAF1	(761253..762590)	RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1
YBR280C	0	762780	764693	ON	2	SAF1	complement(762780..764693)	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YBR281C	0	764966	767602	ON	2	DUG2	complement(764966..767602)	Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YBR282W	1	768236	768676	ON	2	MRPL27	(768236..768676)	Mitochondrial ribosomal protein of the large subunit
YBR283C	0	768939	770411	ON	2	SSH1	complement(768939..770411)	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YBR284W	1	771235	773628	ON	2	YBR284W	(771235..773628)	Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YBR285W	1	773918	774352	ON	2	YBR285W	(773918..774352)	Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C
YBR286W	1	774696	776309	ON	2	APE3	(774696..776309)	Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YBR287W	1	776567	777850	ON	2	YBR287W	(776567..777850)	Protein of unknown function; mutation results in a zinc sensitive phenotype
YBR288C	0	778008	779459	ON	2	APM3	complement(778008..779459)	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
YBR289W	1	779663	782380	ON	2	SNF5	(779663..782380)	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
YBR290W	1	782587	783552	ON	2	BSD2	(782587..783552)	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
YBR291C	0	783669	784568	ON	2	CTP1	complement(783669..784568)	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YBR292C	0	784698	785069	OFF	2	YBR292C	complement(784698..785069)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YBR293W	1	787001	788425	ON	2	VBA2	(787001..788425)	Permease of basic amino acids in the vacuolar membrane
YBR294W	1	789230	791809	ON	2	SUL1	(789230..791809)	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YBR295W	1	792843	796493	ON	2	PCA1	(792843..796493)	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YBR296C	0	796792	798516	ON	2	PHO89	complement(796792..798516)	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YBR296C-A	0	800117	800236	OFF	2	YBR296C-A	complement(800117..800236)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR297W	1	800517	801923	ON	2	MAL33	(800517..801923)	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YBR298C	0	802625	804469	ON	2	MAL31	complement(802625..804469)	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
YBR298C-A	0	805029	805250	OFF	2	YBR298C-A	complement(805029..805250)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR299W	1	805345	807099	ON	2	MAL32	(805345..807099)	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C
YBR300C	0	808594	809091	OFF	2	YBR300C	complement(808594..809091)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YBR301W	1	809051	809413	ON	2	DAN3	(809051..809413)	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YBR302C	0	810334	811473	ON	2	COS2	complement(810334..811473)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YCL076W	1	1392	2135	OFF	3	YCL076W	(1392..2135)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL075W	1	2126	2566	OFF	3	YCL075W	(2126..2566)	Pseudogene: encodes fragment of Ty Pol protein
YCL074W	1	2824	3750	OFF	3	YCL074W	(2824..3750)	Pseudogene: encodes fragment of Ty Pol protein
YCL073C	0	6479	8326	ON	3	YCL073C	complement(6479..8326)	Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W
YCL069W	1	9706	11082	ON	3	VBA3	(9706..11082)	Permease of basic amino acids in the vacuolar membrane
YCL068C	0	11503	12285	ON	3	YCL068C	complement(11503..12285)	Putative protein of unknown function
YCL067C	0	12386	13018	ON	3	HMLALPHA2	complement(12386..13018)	Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression
YCL066W	1	13282	13809	ON	3	HMLALPHA1	(13282..13809)	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
YCL065W	1	13751	14119	OFF	3	YCL065W	(13751..14119)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1
YCL064C	0	15798	16880	ON	3	CHA1	complement(15798..16880)	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YCL063W	1	17290	18561	ON	3	VAC17	(17290..18561)	Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YCL061C	0	18816	22106	ON	3	MRC1	complement(18816..22106)	S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p; protein involved in replication checkpoint
YCL059C	0	22429	23379	ON	3	KRR1	complement(22429..23379)	Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YCL058C	0	23523	23981	OFF	3	FYV5	complement(23523..23981)	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YCL058W-A	1	23584	23925	ON	3	YCL058W-A	(23584..23925)	Protein of unknown function; identified by homology to Ashbya gossypii
YCL057C-A	0	24032	24325	ON	3	YCL057C-A	complement(24032..24325)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL057W	1	24768	26906	ON	3	PRD1	(24768..26906)	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
YCL056C	0	26925	27359	ON	3	YCL056C	complement(26925..27359)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCL055W	1	27929	28936	ON	3	KAR4	(27929..28936)	Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
YCL054W	1	31449	33974	ON	3	SPB1	(31449..33974)	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YCL052C	0	34143	35393	ON	3	PBN1	complement(34143..35393)	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
YCL051W	1	35865	37616	ON	3	LRE1	(35865..37616)	Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes
YCL050C	0	37836	38801	ON	3	APA1	complement(37836..38801)	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YCL049C	0	39786	40724	ON	3	YCL049C	complement(39786..40724)	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YCL048W-A	1	41488	41727	ON	3	YCL048W-A	(41488..41727)	Putative protein of unknown function
YCL048W	1	42165	43556	ON	3	SPS22	(42165..43556)	Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YCL047C	0	43661	44437	ON	3	YCL047C	complement(43661..44437)	Putative protein of unknown function
YCL045C	0	44623	46905	ON	3	YCL045C	complement(44623..46905)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential gene
YCL046W	1	46640	46963	OFF	3	YCL046W	(46640..46963)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
YCL044C	0	47111	48364	ON	3	MGR1	complement(47111..48364)	Subunit, with Yme1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; required for growth of cells lacking the mitochondrial genome
YCL043C	0	48653	50221	ON	3	PDI1	complement(48653..50221)	Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YCL041C	0	50133	50627	OFF	3	YCL041C	complement(50133..50627)	Hypothetical protein; open reading frame overlaps 5' end of essential PDI1 gene encoding protein disulfide isomerase
YCL042W	1	50584	50943	OFF	3	YCL042W	(50584..50943)	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YCL040W	1	50838	52340	ON	3	GLK1	(50838..52340)	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources
YCL039W	1	52645	54882	ON	3	GID7	(52645..54882)	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
YCL038C	0	54941	56527	ON	3	ATG22	complement(54941..56527)	Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole
YCL037C	0	57374	58678	ON	3	SRO9	complement(57374..58678)	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YCL036W	1	59026	60726	ON	3	GFD2	(59026..60726)	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YCL035C	0	60841	61173	ON	3	GRX1	complement(60841..61173)	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YCL034W	1	61658	62722	ON	3	LSB5	(61658..62722)	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YCL033C	0	62776	63282	ON	3	YCL033C	complement(62776..63282)	Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene
YCL032W	1	63441	64481	ON	3	STE50	(63441..64481)	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
YCL031C	0	64675	65568	ON	3	RRP7	complement(64675..65568)	Essential protein involved in rRNA processing and ribosome biogenesis
YCL030C	0	65934	68333	ON	3	HIS4	complement(65934..68333)	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
YCL029C	0	68599	69921	ON	3	BIK1	complement(68599..69921)	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
YCL028W	1	70150	71367	ON	3	RNQ1	(70150..71367)	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
YCL027W	1	71803	73341	ON	3	FUS1	(71803..73341)	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YCL026C-B	0	73405	73986	ON	3	HBN1	complement(73405..73986)	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YCL026C-A	0	74704	75285	ON	3	FRM2	complement(74704..75285)	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases
YCL025C	0	76018	77919	ON	3	AGP1	complement(76018..77919)	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YCL023C	0	78949	79296	OFF	3	YCL023C	complement(78949..79296)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YCL024W	1	79162	82275	ON	3	KCC4	(79162..82275)	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YCL022C	0	81570	82085	OFF	3	YCL022C	complement(81570..82085)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YCL021W-A	1	83620	83997	ON	3	YCL021W-A	(83620..83997)	Putative protein of unknown function
YCL018W	1	91324	92418	ON	3	LEU2	(91324..92418)	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YCL017C	0	92777	94270	ON	3	NFS1	complement(92777..94270)	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
YCL016C	0	94621	95763	ON	3	DCC1	complement(94621..95763)	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YCL014W	1	96281	101191	ON	3	BUD3	(96281..101191)	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
YCL012C	0	101317	101788	ON	3	YCL012C	complement(101317..101633,101701..101788)	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YCL011C	0	102075	103358	ON	3	GBP2	complement(102075..103358)	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro
YCL010C	0	103571	104350	ON	3	SGF29	complement(103571..104350)	SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
YCL009C	0	104619	105548	ON	3	ILV6	complement(104619..105548)	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
YCL008C	0	105696	106853	ON	3	STP22	complement(105696..106853)	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
YCL007C	0	106974	107366	OFF	3	YCL007C	complement(106974..107366)	Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YCL005W-A	1	107023	107417	ON	3	VMA9	(107023..107033,107111..107191,107288..107417)	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
YCL005W	1	108021	108791	ON	3	LDB16	(108021..108791)	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
YCL004W	1	109105	110670	ON	3	PGS1	(109105..110670)	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
YCL002C	0	110843	111674	ON	3	YCL002C	complement(110843..111556,111633..111674)	Putative protein of unknown function; YCL002C is not an essential gene
YCL001W	1	111914	112480	ON	3	RER1	(111914..112480)	Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YCL001W-A	1	113078	113539	OFF	3	YCL001W-A	(113078..113539)	Putative protein of unknown function; YCL001W-A is not an essential gene
YCL001W-B	1	113768	114022	ON	3	YCL001W-B	(113768..114022)	Putative protein of unknown function; identified by homology
YCR001W	1	115683	115997	OFF	3	YCR001W	(115683..115997)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YCR002C	0	117378	118346	ON	3	CDC10	complement(117378..118346)	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YCR003W	1	118618	119169	ON	3	MRPL32	(118618..119169)	Mitochondrial ribosomal protein of the large subunit
YCR004C	0	119573	120316	ON	3	YCP4	complement(119573..120316)	Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR005C	0	120944	122326	ON	3	CIT2	complement(120944..122326)	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YCR006C	0	122528	123001	OFF	3	YCR006C	complement(122528..123001)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C	0	126009	126728	ON	3	YCR007C	complement(126009..126728)	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YCR008W	1	128468	130279	ON	3	SAT4	(128468..130279)	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YCR009C	0	130743	131540	ON	3	RVS161	complement(130743..131540)	Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YCR010C	0	132271	133122	ON	3	ADY2	complement(132271..133122)	Acetate transporter required for normal sporulation
YCR011C	0	133722	136871	ON	3	ADP1	complement(133722..136871)	Putative ATP-dependent permease of the ABC transporter family of proteins
YCR012W	1	137744	138994	ON	3	PGK1	(137744..138994)	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YCR013C	0	138400	139047	OFF	3	YCR013C	complement(138400..139047)	ubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in the gcr1 null mutant
YCR014C	0	139183	140931	ON	3	POL4	complement(139183..140931)	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
YCR015C	0	141215	142168	ON	3	YCR015C	complement(141215..142168)	Putative protein of unknown function; YCR015C is not an essential gene
YCR016W	1	143632	144504	ON	3	YCR016W	(143632..144504)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YCR017C	0	144771	147632	ON	3	CWH43	complement(144771..147632)	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
YCR018C	0	148236	148901	ON	3	SRD1	complement(148236..148901)	Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YCR018C-A	0	151606	151860	OFF	3	YCR018C-A	complement(151606..151860)	Putative protein of unknown function; encoded opposite a Ty1 LTR
YCR019W	1	152835	153926	ON	3	MAK32	(152835..153926)	Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YCR020C	0	154010	154657	ON	3	PET18	complement(154010..154657)	Protein required for respiratory growth and stability of the mitochondrial genome
YCR020C-A	0	154828	155094	ON	3	MAK31	complement(154828..155094)	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
YCR020W-B	1	155318	155554	ON	3	HTL1	(155318..155554)	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YCR021C	0	156105	157103	ON	3	HSP30	complement(156105..157103)	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YCR022C	0	157417	157761	OFF	3	YCR022C	complement(157417..157761)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YCR023C	0	158534	160369	ON	3	YCR023C	complement(158534..160369)	Putative protein of unknown function; YCR023C is not an essential gene
YCR024C	0	160740	162218	ON	3	SLM5	complement(160740..162218)	Mitochondrial asparaginyl-tRNA synthetase
YCR024C-B	0	162595	162861	OFF	3	YCR024C-B	complement(162595..162861)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YCR024C-A	0	162941	163063	ON	3	PMP1	complement(162941..163063)	Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines
YCR025C	0	163442	163852	OFF	3	YCR025C	complement(163442..163852)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YCR026C	0	164107	166335	ON	3	NPP1	complement(164107..166335)	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YCR027C	0	167366	167995	ON	3	RHB1	complement(167366..167995)	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
YCR028C	0	170882	172420	ON	3	FEN2	complement(170882..172420)	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
YCR028C-A	0	172946	173436	ON	3	RIM1	complement(172946..173111,173195..173436)	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
YCR030C	0	173822	176434	ON	3	SYP1	complement(173822..176434)	Protein with a potential role in actin cytoskeletal organization; overexpression suppresses a pfy1 (profilin) null mutation
YCR031C	0	177496	178216	ON	3	RPS14A	complement(177496..177902,178210..178216)	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YCR032W	1	179516	186019	ON	3	BPH1	(179516..186019)	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YCR033W	1	186485	190165	ON	3	SNT1	(186485..190165)	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
YCR034W	1	190588	191631	ON	3	FEN1	(190588..191631)	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YCR035C	0	191830	193014	ON	3	RRP43	complement(191830..193014)	Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
YCR036W	1	193293	194294	ON	3	RBK1	(193293..194294)	Putative ribokinase
YCR037C	0	194410	197181	ON	3	PHO87	complement(194410..197181)	Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments
YCR038C	0	197617	199545	ON	3	BUD5	complement(197617..199545)	GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
YCR038W-A	1	199289	199414	OFF	3	YCR038W-A	(199289..199414)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species
YCR039C	0	199542	200174	ON	3	MATALPHA2	complement(199542..200174)	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette
YCR040W	1	200438	200965	ON	3	MATALPHA1	(200438..200965)	Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette
YCR041W	1	200907	201239	OFF	3	YCR041W	(200907..201239)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR042C	0	201170	205393	ON	3	TAF2	complement(201170..205393)	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
YCR043C	0	206257	206640	ON	3	YCR043C	complement(206257..206640)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
YCR044C	0	206873	207946	ON	3	PER1	complement(206873..207946)	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
YCR045C	0	208131	209606	ON	3	YCR045C	complement(208131..209606)	Putative protein of unknown function
YCR045W-A	1	208747	209097	OFF	3	YCR045W-A	(208747..209097)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YCR046C	0	209910	210419	ON	3	IMG1	complement(209910..210419)	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YCR047C	0	210714	211541	ON	3	BUD23	complement(210714..211541)	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YCR047W-A	1	211297	211503	OFF	3	YCR047W-A	(211297..211503)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YCR049C	0	211867	212313	OFF	3	YCR049C	complement(211867..212313)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR048W	1	211925	213757	ON	3	ARE1	(211925..213757)	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen
YCR050C	0	213460	213768	OFF	3	YCR050C	complement(213460..213768)	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YCR051W	1	214067	214735	ON	3	YCR051W	(214067..214735)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YCR052W	1	214990	216441	ON	3	RSC6	(214990..216441)	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YCR053W	1	216693	218237	ON	3	THR4	(216693..218237)	Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
YCR054C	0	218372	220063	ON	3	CTR86	complement(218372..220063)	Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis
YCR057C	0	220453	223224	ON	3	PWP2	complement(220453..223224)	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YCR059C	0	223450	224226	ON	3	YIH1	complement(223450..224226)	Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene
YCR060W	1	224395	224730	ON	3	TAH1	(224395..224730)	HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs
YCR061W	1	225559	227454	ON	3	YCR061W	(225559..227454)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YCR064C	0	228091	228501	OFF	3	YCR064C	complement(228091..228501)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
YCR063W	1	228314	228787	ON	3	BUD31	(228314..228787)	Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YCR065W	1	229306	231000	ON	3	HCM1	(229306..231000)	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YCR066W	1	231496	232959	ON	3	RAD18	(231496..232959)	Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
YCR067C	0	233121	236318	ON	3	SED4	complement(233121..236318)	Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p
YCR068W	1	237210	238772	ON	3	ATG15	(237210..238772)	Lipase, required for intravacuolar lysis of autophagic bodies; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YCR069W	1	239051	240007	ON	3	CPR4	(239051..240007)	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
YCR071C	0	240099	240539	ON	3	IMG2	complement(240099..240539)	Mitochondrial ribosomal protein of the small subunit
YCR072C	0	240801	242348	ON	3	RSA4	complement(240801..242348)	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YCR073C	0	242585	246580	ON	3	SSK22	complement(242585..246580)	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
YCR073W-A	1	246960	247907	ON	3	SOL2	(246960..247907)	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YCR075C	0	248030	248812	ON	3	ERS1	complement(248030..248812)	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YCR075W-A	1	248972	249199	ON	3	YCR075W-A	(248972..249199)	Putative protein of unknown function; identified by homology to Ashbya gossypii
YCR076C	0	249290	250042	ON	3	YCR076C	complement(249290..250042)	Putative protein of unknown function; YCR076C is not an essential gene
YCR077C	0	250235	252625	ON	3	PAT1	complement(250235..252625)	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
YCR079W	1	252842	254170	ON	3	PTC6	(252842..254170)	Phosphoprotein phosphatase type 2C similar to mammalian PP1Ks; involved in mitophagy; localized to mitochondrial inner membrane space; null mutant is sensitive to rapamycin
YCR081W	1	254368	258651	ON	3	SRB8	(254368..258651)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
YCR081C-A	0	258412	258648	OFF	3	YCR081C-A	complement(258412..258648)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YCR082W	1	258880	259266	ON	3	AHC2	(258880..259266)	Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus
YCR083W	1	259575	259958	ON	3	TRX3	(259575..259958)	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
YCR084C	0	260308	262449	ON	3	TUP1	complement(260308..262449)	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YCR085W	1	262913	263266	OFF	3	YCR085W	(262913..263266)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR086W	1	263389	263961	ON	3	CSM1	(263389..263961)	Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
YCR087W	1	263973	264488	OFF	3	YCR087W	(263973..264488)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
YCR087C-A	0	264003	264464	ON	3	YCR087C-A	complement(264003..264464)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YCR088W	1	265065	266843	ON	3	ABP1	(265065..266843)	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
YCR089W	1	267431	272260	ON	3	FIG2	(267431..272260)	Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
YCR090C	0	272312	272860	ON	3	YCR090C	complement(272312..272860)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YCR091W	1	274401	276563	ON	3	KIN82	(274401..276563)	Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YCR092C	0	276761	279904	ON	3	MSH3	complement(276761..279904)	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
YCR093W	1	280114	286440	ON	3	CDC39	(280114..286440)	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YCR094W	1	286759	287934	ON	3	CDC50	(286759..287934)	Endosomal protein that regulates cell polarity; similar to Ynr048wp and Lem3p
YCR095C	0	288167	289255	ON	3	YCR095C	complement(288167..289255)	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YCR095W-A	1	289636	289794	OFF	3	YCR095W-A	(289636..289794)	Putative protein of unknown function
YCR096C	0	293176	293535	OFF	3	HMRA2	complement(293176..293535)	Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system
YCR097W	1	293832	294318	ON	3	HMRA1	(293832..293936,293991..294236,294289..294318)	Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells
YCR097W-A	1	294436	294702	OFF	3	YCR097W-A	(294436..294702)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YCR098C	0	297046	298602	ON	3	GIT1	complement(297046..298602)	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YCR099C	0	300829	301296	ON	3	YCR099C	complement(300829..301296)	Putative protein of unknown function
YCR100C	0	301268	302218	ON	3	YCR100C	complement(301268..302218)	Putative protein of unknown function
YCR101C	0	302479	303027	ON	3	YCR101C	complement(302479..303027)	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YCR102C	0	304358	305464	ON	3	YCR102C	complement(304358..305464)	Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YCR102W-A	1	306732	306929	OFF	3	YCR102W-A	(306732..306929)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR104W	1	307798	308172	ON	3	PAU3	(307798..308172)	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YCR105W	1	309067	310152	ON	3	ADH7	(309067..310152)	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YCR106W	1	310955	313453	ON	3	RDS1	(310955..313453)	Zinc cluster transcription factor involved in conferring resistance to cycloheximide
YCR107W	1	313887	314978	ON	3	AAD3	(313887..314978)	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YCR108C	0	315994	316185	OFF	3	YCR108C	complement(315994..316185)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL248W	1	1802	2953	ON	4	COS7	(1802..2953)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL247W-A	1	3762	3836	OFF	4	YDL247W-A	(3762..3836)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species
YDL247W	1	5985	7814	ON	4	MPH2	(5985..7814)	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication
YDL246C	0	8683	9756	ON	4	SOR2	complement(8683..9756)	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YDL245C	0	11657	13360	ON	4	HXT15	complement(11657..13360)	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YDL244W	1	16204	17226	ON	4	THI13	(16204..17226)	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDL243C	0	17577	18566	ON	4	AAD4	complement(17577..18566)	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YDL242W	1	18959	19312	OFF	4	YDL242W	(18959..19312)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL241W	1	20635	21006	ON	4	YDL241W	(20635..21006)	Putative protein of unknown function; YDL241W is not an essential gene
YDL240C-A	0	22471	22608	OFF	4	YDL240C-A	complement(22471..22608)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species
YDL240W	1	22823	25876	ON	4	LRG1	(22823..25876)	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YDL239C	0	26403	28775	ON	4	ADY3	complement(26403..28775)	Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p
YDL238C	0	28985	30454	ON	4	GUD1	complement(28985..30454)	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YDL237W	1	30657	31829	ON	4	YDL237W	(30657..31829)	Putative protein of unknown function; YDL237W is not an essential gene
YDL236W	1	32296	33234	ON	4	PHO13	(32296..33234)	Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YDL235C	0	33415	33918	ON	4	YPD1	complement(33415..33918)	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
YDL234C	0	34238	36478	ON	4	GYP7	complement(34238..36478)	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YDL233W	1	36798	38174	ON	4	YDL233W	(36798..38174)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene
YDL232W	1	38488	38598	ON	4	OST4	(38488..38598)	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex
YDL231C	0	38868	42245	ON	4	BRE4	complement(38868..42245)	Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
YDL230W	1	42701	43708	ON	4	PTP1	(42701..43708)	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria
YDL229W	1	44066	45907	ON	4	SSB1	(44066..45907)	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YDL228C	0	45278	45919	OFF	4	YDL228C	complement(45278..45919)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YDL227C	0	46272	48032	ON	4	HO	complement(46272..48032)	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YDL226C	0	51116	52174	ON	4	GCS1	complement(51116..52174)	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YDL225W	1	52446	54101	ON	4	SHS1	(52446..54101)	One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
YDL224C	0	54398	56347	ON	4	WHI4	complement(54398..56347)	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YDL223C	0	57266	60406	ON	4	HBT1	complement(57266..60406)	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YDL222C	0	60873	61802	ON	4	FMP45	complement(60873..61802)	Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YDL221W	1	62012	62563	OFF	4	YDL221W	(62012..62563)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YDL220C	0	62245	65019	ON	4	CDC13	complement(62245..65019)	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
YDL219W	1	65243	65766	ON	4	DTD1	(65243..65307,65379..65766)	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YDL218W	1	66494	67447	ON	4	YDL218W	(66494..67447)	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YDL217C	0	67984	68607	ON	4	TIM22	complement(67984..68607)	Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane
YDL216C	0	68998	70320	ON	4	RRI1	complement(68998..70320)	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
YDL215C	0	70641	73919	ON	4	GDH2	complement(70641..73919)	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDL214C	0	74447	76546	ON	4	PRR2	complement(74447..76546)	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YDL213C	0	77290	77967	ON	4	NOP6	complement(77290..77967)	Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YDL212W	1	78427	79059	ON	4	SHR3	(78427..79059)	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YDL211C	0	79295	80413	ON	4	YDL211C	complement(79295..80413)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL210W	1	84271	85986	ON	4	UGA4	(84271..85986)	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YDL209C	0	86208	87227	ON	4	CWC2	complement(86208..87227)	Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p
YDL208W	1	87513	87983	ON	4	NHP2	(87513..87983)	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YDL207W	1	88249	89865	ON	4	GLE1	(88249..89865)	Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal
YDL206W	1	90177	92465	ON	4	YDL206W	(90177..92465)	Putative protein of unknown function; YDL206W is not an essential protein
YDL205C	0	92763	93746	ON	4	HEM3	complement(92763..93746)	Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YDL204W	1	94606	95787	ON	4	RTN2	(94606..95787)	Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YDL203C	0	96083	97954	ON	4	YDL203C	complement(96083..97954)	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YDL202W	1	98476	99225	ON	4	MRPL11	(98476..99225)	Mitochondrial ribosomal protein of the large subunit
YDL201W	1	99562	100422	ON	4	TRM8	(99562..100422)	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YDL200C	0	100502	101068	ON	4	MGT1	complement(100502..101068)	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
YDL199C	0	101291	103354	ON	4	YDL199C	complement(101291..103354)	Putative transporter, member of the sugar porter family
YDL198C	0	103650	104552	ON	4	GGC1	complement(103650..104552)	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
YDL197C	0	104918	106495	ON	4	ASF2	complement(104918..106495)	Anti-silencing protein that causes derepression of silent loci when overexpressed
YDL196W	1	106742	107071	OFF	4	YDL196W	(106742..107071)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YDL195W	1	107209	111030	ON	4	SEC31	(107209..111030)	Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation
YDL194W	1	111581	114235	ON	4	SNF3	(111581..114235)	Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YDL193W	1	114673	115800	ON	4	NUS1	(114673..115800)	Prenyltransferase, required for cell viability; involved in protein trafficking
YDL192W	1	116322	116867	ON	4	ARF1	(116322..116867)	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YDL191W	1	117665	118518	ON	4	RPL35A	(117665..117667,118159..118518)	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YDL190C	0	118708	121593	ON	4	UFD2	complement(118708..121593)	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
YDL189W	1	122217	123590	ON	4	RBS1	(122217..123590)	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YDL188C	0	123866	124999	ON	4	PPH22	complement(123866..124999)	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YDL187C	0	125510	125839	OFF	4	YDL187C	complement(125510..125839)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL186W	1	125617	126450	ON	4	YDL186W	(125617..126450)	Putative protein of unknown function; YDL186W is not an essential gene
YDL185C-A	0	126609	126836	OFF	4	YDL185C-A	complement(126609..126836)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species
YDL185W	1	126788	130003	ON	4	TFP1	(126788..130003)	Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YDL184C	0	130408	130485	ON	4	RPL41A	complement(130408..130485)	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable
YDL183C	0	130872	131834	ON	4	YDL183C	complement(130872..131834)	Putative protein of unknown function; YBR063C is not an essential gene
YDL182W	1	133438	134724	ON	4	LYS20	(133438..134724)	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YDL181W	1	135180	135437	ON	4	INH1	(135180..135437)	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase, inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p and both Inh1p and Stf1p exhibit the potential to form coiled-coil structures
YDL180W	1	135897	137540	ON	4	YDL180W	(135897..137540)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDL179W	1	138292	139206	ON	4	PCL9	(138292..139206)	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YDL178W	1	139523	141115	ON	4	DLD2	(139523..141115)	D-lactate dehydrogenase, located in the mitochondrial matrix
YDL177C	0	141210	141722	ON	4	YDL177C	complement(141210..141722)	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
YDL176W	1	142098	144224	ON	4	YDL176W	(142098..144224)	Putative protein of unknown function; YDL176W is not an essential gene
YDL175C	0	144485	145519	ON	4	AIR2	complement(144485..145519)	RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p
YDL174C	0	145827	147590	ON	4	DLD1	complement(145827..147590)	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YDL173W	1	148192	149079	ON	4	YDL173W	(148192..149079)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YDL172C	0	148608	149087	OFF	4	YDL172C	complement(148608..149087)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDL171C	0	149204	155641	ON	4	GLT1	complement(149204..155641)	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YDL170W	1	156319	157905	ON	4	UGA3	(156319..157905)	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YDL169C	0	158065	158736	ON	4	UGX2	complement(158065..158736)	Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YDL168W	1	159605	160765	ON	4	SFA1	(159605..160765)	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
YDL167C	0	160996	163155	ON	4	NRP1	complement(160996..163155)	Protein of unknown function, rich in asparagine residues
YDL166C	0	163450	164043	ON	4	FAP7	complement(163450..164043)	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YDL165W	1	164291	164866	ON	4	CDC36	(164291..164866)	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YDL164C	0	164988	167255	ON	4	CDC9	complement(164988..167255)	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YDL163W	1	166957	167259	OFF	4	YDL163W	(166957..167259)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YDL162C	0	167360	167716	OFF	4	YDL162C	complement(167360..167716)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
YDL161W	1	167715	169079	ON	4	ENT1	(167715..169079)	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YDL160C-A	0	169367	169609	ON	4	YDL160C-A	complement(169367..169609)	Putative protein of unknown function
YDL160C	0	170411	171931	ON	4	DHH1	complement(170411..171931)	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
YDL159W-A	1	172183	172314	OFF	4	YDL159W-A	(172183..172314)	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YDL159W	1	172482	174029	ON	4	STE7	(172482..174029)	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway
YDL159C-B	0	173057	173233	OFF	4	YDL159C-B	complement(173057..173233)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDL158C	0	173867	174175	OFF	4	YDL158C	complement(173867..174175)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDL157C	0	174233	174589	ON	4	YDL157C	complement(174233..174589)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL156W	1	174919	176487	ON	4	YDL156W	(174919..176487)	Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL155W	1	176774	178057	ON	4	CLB3	(176774..178057)	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YDL154W	1	178335	181040	ON	4	MSH5	(178335..181040)	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
YDL153C	0	181187	183019	ON	4	SAS10	complement(181187..183019)	Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
YDL152W	1	182823	183188	OFF	4	YDL152W	(182823..183188)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YDL151C	0	183319	183900	OFF	4	BUD30	complement(183319..183900)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDL150W	1	183344	184612	ON	4	RPC53	(183344..184612)	RNA polymerase III subunit C53
YDL149W	1	184926	187919	ON	4	ATG9	(184926..187919)	Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes
YDL148C	0	188155	190587	ON	4	NOP14	complement(188155..190587)	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YDL147W	1	190925	192262	ON	4	RPN5	(190925..192262)	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
YDL146W	1	192751	194226	ON	4	LDB17	(192751..194226)	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YDL145C	0	194572	198177	ON	4	COP1	complement(194572..198177)	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YDL144C	0	198663	199733	ON	4	YDL144C	complement(198663..199733)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.
YDL143W	1	199997	201583	ON	4	CCT4	(199997..201583)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDL142C	0	201720	202571	ON	4	CRD1	complement(201720..202571)	Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and function
YDL141W	1	203040	205112	ON	4	BPL1	(203040..205112)	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YDL140C	0	205361	210562	ON	4	RPO21	complement(205361..210562)	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
YDL139C	0	211376	212047	ON	4	SCM3	complement(211376..212047)	Protein of unknown function; contains nuclear export signal (NES); associates with CEN DNA; required for G2/M progression and localization of Cse4p; isolated as a high-copy suppressor of mutations in the histone fold domain (HFD) of CSE4
YDL138W	1	213352	215643	ON	4	RGT2	(213352..215643)	Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YDL137W	1	216529	217074	ON	4	ARF2	(216529..217074)	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YDL136W	1	217600	218367	ON	4	RPL35B	(217600..217602,218008..218367)	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YDL135C	0	218680	219288	ON	4	RDI1	complement(218680..219288)	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YDL134C	0	219662	220771	ON	4	PPH21	complement(219662..220771)	Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YDL133C-A	0	221724	221801	ON	4	RPL41B	complement(221724..221801)	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable
YDL133W	1	222427	223740	ON	4	YDL133W	(222427..223740)	Putative protein of unknown function
YDL132W	1	224304	226751	ON	4	CDC53	(224304..226751)	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YDL131W	1	227393	228715	ON	4	LYS21	(227393..228715)	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
YDL130W-A	1	229171	229431	ON	4	STF1	(229171..229431)	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YDL130W	1	229906	230527	ON	4	RPP1B	(229906..230019,230321..230527)	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
YDL129W	1	231024	231899	ON	4	YDL129W	(231024..231899)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
YDL128W	1	232652	233887	ON	4	VCX1	(232652..233887)	Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YDL127W	1	234927	235853	ON	4	PCL2	(234927..235853)	G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth
YDL126C	0	236157	238664	ON	4	CDC48	complement(236157..238664)	ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YDL125C	0	239019	239606	ON	4	HNT1	complement(239019..239398,239510..239606)	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YDL124W	1	240259	241197	ON	4	YDL124W	(240259..241197)	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family
YDL123W	1	241418	241840	ON	4	SNA4	(241418..241840)	Protein of unknown function, localized to the vacuolar outer membrane
YDL122W	1	242552	244981	ON	4	UBP1	(242552..244981)	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
YDL121C	0	245133	245582	ON	4	YDL121C	complement(245133..245582)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YDL120W	1	245923	246447	ON	4	YFH1	(245923..246447)	Frataxin, regulates mitochondrial iron accumulation; interacts with Isu1p which promotes Fe-S cluster assembly; interacts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia
YDL119C	0	246689	247612	ON	4	YDL119C	complement(246689..247612)	Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
YDL118W	1	247302	247682	OFF	4	YDL118W	(247302..247682)	Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein
YDL117W	1	248581	251238	ON	4	CYK3	(248581..251238)	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YDL116W	1	251566	253746	ON	4	NUP84	(251566..253746)	Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
YDL115C	0	253995	255126	ON	4	IWR1	complement(253995..254974,255045..255126)	Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
YDL114W-A	1	254935	255048	OFF	4	YDL114W-A	(254935..255048)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts
YDL114W	1	255604	256530	ON	4	YDL114W	(255604..256530)	Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YDL113C	0	256633	258555	ON	4	ATG20	complement(256633..258555)	Protein required for transport of aminopeptidase I (Lap4p) through the cytoplasm-to-vacuole targeting pathway; binds phosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate
YDL112W	1	258915	263225	ON	4	TRM3	(258915..263225)	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YDL111C	0	263313	264110	ON	4	RRP42	complement(263313..264110)	Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p
YDL110C	0	264512	264964	ON	4	TMA17	complement(264512..264964)	Protein of unknown function that associates with ribosomes
YDL109C	0	265258	267201	ON	4	YDL109C	complement(265258..267201)	Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YDL108W	1	267698	268699	ON	4	KIN28	(267698..267725,267807..268699)	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YDL107W	1	268921	269976	ON	4	MSS2	(268921..269976)	Peripherally bound inner membrane protein of the mitochondrial matrix, binds to the Cox2p C-terminal tail to facilitate its translocation through the inner membrane
YDL106C	0	270222	271901	ON	4	PHO2	complement(270222..271901)	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
YDL105W	1	272389	273597	ON	4	NSE4	(272389..273597)	Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex
YDL104C	0	273653	274876	ON	4	QRI7	complement(273653..274876)	Putative metalloprotease, similar to O-sialoglycoprotein metallopeptidase from P. haemolytica; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL103C	0	275148	276581	ON	4	QRI1	complement(275148..276581)	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
YDL102W	1	276872	280165	ON	4	POL3	(276872..280165)	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YDL101C	0	280307	281848	ON	4	DUN1	complement(280307..281848)	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
YDL100C	0	282112	283176	ON	4	GET3	complement(282112..283176)	ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress
YDL099W	1	283419	284444	ON	4	BUG1	(283419..284444)	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YDL098C	0	284581	285165	ON	4	SNU23	complement(284581..285165)	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
YDL097C	0	285391	286695	ON	4	RPN6	complement(285391..286695)	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
YDL096C	0	286998	287324	OFF	4	OPI6	complement(286998..287324)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
YDL095W	1	287059	289512	ON	4	PMT1	(287059..289512)	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
YDL094C	0	289572	290081	OFF	4	YDL094C	complement(289572..290081)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential
YDL093W	1	289909	292140	ON	4	PMT5	(289909..292140)	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
YDL092W	1	292781	293221	ON	4	SRP14	(292781..293221)	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YDL091C	0	293392	294759	ON	4	UBX3	complement(293392..294759)	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDL090C	0	295034	296329	ON	4	RAM1	complement(295034..296329)	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YDL089W	1	296820	298274	ON	4	YDL089W	(296820..298274)	Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate
YDL088C	0	298417	300003	ON	4	ASM4	complement(298417..300003)	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
YDL087C	0	300214	300999	ON	4	LUC7	complement(300214..300999)	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site
YDL086W	1	301413	302234	ON	4	YDL086W	(301413..302234)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
YDL086C-A	0	301655	302089	OFF	4	YDL086C-A	complement(301655..302089)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YDL085C-A	0	302464	302670	ON	4	YDL085C-A	complement(302464..302670)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL085W	1	303211	304848	ON	4	NDE2	(303211..304848)	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YDL084W	1	305237	306577	ON	4	SUB2	(305237..306577)	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YDL083C	0	306926	307789	ON	4	RPS16B	complement(306926..307333,307766..307789)	Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YDL082W	1	308424	309388	ON	4	RPL13A	(308424..308427,308793..309388)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YDL081C	0	309802	310122	ON	4	RPP1A	complement(309802..310122)	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
YDL080C	0	310642	312471	ON	4	THI3	complement(310642..312471)	Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
YDL079C	0	312951	314748	ON	4	MRK1	complement(312951..314044,314337..314748)	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YDL078C	0	315357	316388	ON	4	MDH3	complement(315357..316388)	Cytoplasmic malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YDL077C	0	316971	320120	ON	4	VAM6	complement(316971..320120)	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
YDL076C	0	320668	321552	ON	4	RXT3	complement(320668..321552)	Subunit of the RPD3L complex; involved in histone deacetylation
YDL075W	1	322226	322988	ON	4	RPL31A	(322226..322282,322704..322988)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDL074C	0	324047	326149	ON	4	BRE1	complement(324047..326149)	E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
YDL073W	1	326613	329567	ON	4	YDL073W	(326613..329567)	Putative protein of unknown function; YDL073W is not an essential gene
YDL072C	0	329836	330447	ON	4	YET3	complement(329836..330447)	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YDL071C	0	330667	331041	OFF	4	YDL071C	complement(330667..331041)	Hypothetical protein
YDL070W	1	331025	332941	ON	4	BDF2	(331025..332941)	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p
YDL069C	0	333121	333810	ON	4	CBS1	complement(333121..333810)	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YDL068W	1	333500	333829	OFF	4	YDL068W	(333500..333829)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDL067C	0	334217	334396	ON	4	COX9	complement(334217..334396)	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YDL066W	1	334835	336121	ON	4	IDP1	(334835..336121)	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YDL065C	0	336249	337277	ON	4	PEX19	complement(336249..337277)	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
YDL064W	1	337487	338070	ON	4	UBC9	(337487..337524,337635..338070)	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
YDL063C	0	338272	340134	ON	4	YDL063C	complement(338272..340134)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene
YDL062W	1	339857	340282	OFF	4	YDL062W	(339857..340282)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
YDL061C	0	340628	340798	ON	4	RPS29B	complement(340628..340798)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
YDL060W	1	341619	343985	ON	4	TSR1	(341619..343985)	Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles
YDL059C	0	344237	344953	ON	4	RAD59	complement(344237..344953)	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YDL058W	1	345665	351037	ON	4	USO1	(345665..351037)	Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YDL057W	1	351434	352420	ON	4	YDL057W	(351434..352420)	Putative protein of unknown function; YDL057W is not an essential gene
YDL056W	1	352877	355378	ON	4	MBP1	(352877..355378)	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
YDL055C	0	355674	356759	ON	4	PSA1	complement(355674..356759)	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YDL054C	0	359825	361285	ON	4	MCH1	complement(359825..361285)	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YDL053C	0	361699	362256	ON	4	PBP4	complement(361699..362256)	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay
YDL052C	0	362672	363583	ON	4	SLC1	complement(362672..363583)	1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; located in lipid particles and endoplasmic reticulum
YDL051W	1	363952	364779	ON	4	LHP1	(363952..364779)	RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YDL050C	0	364446	364817	OFF	4	YDL050C	complement(364446..364817)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDL049C	0	365068	365874	ON	4	KNH1	complement(365068..365874)	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant
YDL048C	0	366739	368211	ON	4	STP4	complement(366739..368211)	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YDL047W	1	369769	370704	ON	4	SIT4	(369769..370704)	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDL046W	1	371237	371758	ON	4	NPC2	(371237..371758)	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
YDL045W-A	1	372245	372532	ON	4	MRP10	(372245..372532)	Mitochondrial ribosomal protein of the small subunit
YDL045C	0	372685	373605	ON	4	FAD1	complement(372685..373605)	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
YDL044C	0	373964	375286	ON	4	MTF2	complement(373964..375286)	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
YDL043C	0	375677	376477	ON	4	PRP11	complement(375677..376477)	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YDL042C	0	376754	378442	ON	4	SIR2	complement(376754..378442)	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan;  plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
YDL041W	1	378099	378452	OFF	4	YDL041W	(378099..378452)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
YDL040C	0	378871	381435	ON	4	NAT1	complement(378871..381435)	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YDL039C	0	381983	382330	OFF	4	PRM7	complement(381983..382330)	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
YDL038C	0	382327	384078	OFF	4	YDL038C	complement(382327..384078)	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL037C	0	384598	385584	ON	4	BSC1	complement(384598..385584)	Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YDL036C	0	387510	388898	ON	4	PUS9	complement(387510..388898)	Mitochondrial tRNA pseudouridine synthase involved in pseudouridylation of mitochondrial tRNAs at position 32
YDL035C	0	389169	392054	ON	4	GPR1	complement(389169..392054)	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
YDL034W	1	391780	392124	OFF	4	YDL034W	(391780..392124)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
YDL033C	0	392656	393909	ON	4	SLM3	complement(392656..393909)	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
YDL032W	1	393687	393998	OFF	4	YDL032W	(393687..393998)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
YDL031W	1	394214	397201	ON	4	DBP10	(394214..397201)	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YDL030W	1	397534	399126	ON	4	PRP9	(397534..399126)	Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YDL029W	1	399337	400635	ON	4	ARP2	(399337..399358,399482..400635)	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YDL028C	0	400994	403288	ON	4	MPS1	complement(400994..403288)	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
YDL027C	0	403692	404954	ON	4	YDL027C	complement(403692..404954)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YDL026W	1	404746	405057	OFF	4	YDL026W	(404746..405057)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDL025C	0	405341	407203	ON	4	YDL025C	complement(405341..407203)	Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YDL025W-A	1	405407	405511	OFF	4	YDL025W-A	(405407..405511)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YDL024C	0	408448	409854	ON	4	DIA3	complement(408448..409854)	Protein of unknown function, involved in invasive and pseudohyphal growth
YDL022C-A	0	409805	410053	OFF	4	YDL022C-A	complement(409805..410053)	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDL023C	0	411758	412078	OFF	4	YDL023C	complement(411758..412078)	Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YDL022W	1	411822	412997	ON	4	GPD1	(411822..412997)	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YDL021W	1	413950	414885	ON	4	GPM2	(413950..414885)	Homolog of Gpm1p phosphoglycerate mutase which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YDL020C	0	415110	416705	ON	4	RPN4	complement(415110..416705)	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
YDL019C	0	417660	421511	ON	4	OSH2	complement(417660..421511)	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YDL018C	0	422830	423507	ON	4	ERP3	complement(422830..423507)	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YDL017W	1	424206	425729	ON	4	CDC7	(424206..425729)	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
YDL016C	0	425567	425869	OFF	4	YDL016C	complement(425567..425869)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
YDL015C	0	425999	426931	ON	4	TSC13	complement(425999..426931)	Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
YDL014W	1	427361	428344	ON	4	NOP1	(427361..428344)	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YDL013W	1	429064	430923	ON	4	SLX5	(429064..430923)	Protein containing a RING finger domain that interacts with Slx8p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
YDL012C	0	431105	431514	ON	4	YDL012C	complement(431105..431383,431470..431514)	Plasma membrane protein of unknown function; YDL012C is not an essential gene
YDL011C	0	432305	432628	OFF	4	YDL011C	complement(432305..432628)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YDL010W	1	432327	433022	ON	4	YDL010W	(432327..433022)	Putative thiol-disulfide oxidoreductase; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL010W is not an essential gene
YDL009C	0	432922	433245	OFF	4	YDL009C	complement(432922..433245)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YDL010W; YDL009C is not an essential gene
YDL008W	1	433494	433991	ON	4	APC11	(433494..433991)	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDL007C-A	0	436564	436821	ON	4	YDL007C-A	complement(436564..436821)	Putative protein of unknown function
YDL007W	1	438044	439357	ON	4	RPT2	(438044..439357)	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YDL006W	1	439906	440751	ON	4	PTC1	(439906..440751)	Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YDL005C	0	441011	442306	ON	4	MED2	complement(441011..442306)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YDL004W	1	443026	443508	ON	4	ATP16	(443026..443508)	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDL003W	1	444680	446380	ON	4	MCD1	(444680..446380)	Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YDL002C	0	446964	447575	ON	4	NHP10	complement(446964..447575)	Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex
YDL001W	1	447981	449273	ON	4	RMD1	(447981..449273)	Cytoplasmic protein required for sporulation
YDR001C	0	450217	452472	ON	4	NTH1	complement(450217..452472)	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
YDR002W	1	453042	453647	ON	4	YRB1	(453042..453647)	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YDR003W	1	454119	454751	ON	4	RCR2	(454119..454751)	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p
YDR003W-A	1	454779	454901	OFF	4	YDR003W-A	(454779..454901)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDR004W	1	455198	456580	ON	4	RAD57	(455198..456580)	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
YDR005C	0	456833	458100	ON	4	MAF1	complement(456833..458014,458095..458100)	Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
YDR006C	0	458539	461244	ON	4	SOK1	complement(458539..461244)	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
YDR007W	1	461839	462513	ON	4	TRP1	(461839..462513)	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YDR008C	0	462249	462599	OFF	4	YDR008C	complement(462249..462599)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR009W	1	463431	464993	ON	4	GAL3	(463431..464993)	Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
YDR010C	0	465048	465380	OFF	4	YDR010C	complement(465048..465380)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR011W	1	465916	470421	ON	4	SNQ2	(465916..470421)	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
YDR012W	1	471850	472938	ON	4	RPL4B	(471850..472938)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YDR013W	1	473154	473780	ON	4	PSF1	(473154..473780)	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YDR014W	1	474043	475986	ON	4	RAD61	(474043..475986)	Protein of unknown function; mutation confers radiation sensitivity
YDR014W-A	1	477794	478282	ON	4	HED1	(477794..478282)	Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase
YDR015C	0	477957	478196	OFF	4	YDR015C	complement(477957..478196)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A
YDR016C	0	478471	478755	ON	4	DAD1	complement(478471..478755)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR017C	0	479112	482264	ON	4	KCS1	complement(479112..482264)	Inositol hexakisphosphate (IP6) kinase, also has inositol heptakisphosphate (IP7) kinase activity, required for proper vacuole morphology and involved in salt stress response; contains two leucine heptad repeats
YDR018C	0	482667	483857	ON	4	YDR018C	complement(482667..483857)	Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YDR019C	0	484160	485362	ON	4	GCV1	complement(484160..485362)	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YDR020C	0	485743	486441	ON	4	YDR020C	complement(485743..486441)	Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null exhibits no apparent phenotype
YDR021W	1	486801	488000	ON	4	FAL1	(486801..488000)	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YDR022C	0	488069	488659	ON	4	CIS1	complement(488069..488659)	Protein required for autophagosome formation in concert with Atg17p; may be involved in microtubule organization; high-copy suppressor of CIK1 deletion
YDR023W	1	489505	490893	ON	4	SES1	(489505..490893)	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YDR024W	1	491014	491499	OFF	4	FYV1	(491014..491499)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
YDR025W	1	491512	492321	ON	4	RPS11A	(491512..491556,491896..492321)	Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YDR026C	0	492553	494265	ON	4	YDR026C	complement(492553..494265)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p
YDR027C	0	494646	497315	ON	4	VPS54	complement(494646..497315)	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
YDR028C	0	497832	500876	ON	4	REG1	complement(497832..500876)	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YDR029W	1	501097	501411	OFF	4	YDR029W	(501097..501411)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YDR030C	0	501750	503270	ON	4	RAD28	complement(501750..503270)	Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSA protein
YDR031W	1	503495	503860	ON	4	MIC14	(503495..503860)	Mitochondrial intermembrane space cysteine motif protein of 14 kDa
YDR032C	0	504096	504692	ON	4	PST2	complement(504096..504692)	Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR033W	1	508144	509106	ON	4	MRH1	(508144..509106)	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; has similarity to Hsp30p and Yro2p, which are induced during heat shock
YDR034C	0	509734	512106	ON	4	LYS14	complement(509734..512106)	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YDR034C-A	0	520513	520689	OFF	4	YDR034C-A	complement(520513..520689)	Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7
YDR034W-B	1	521311	521466	ON	4	YDR034W-B	(521311..521466)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR035W	1	521813	522925	ON	4	ARO3	(521813..522925)	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
YDR036C	0	523208	524710	ON	4	EHD3	complement(523208..524710)	Protein of unconfirmed function, plays an indirect role in endocytic membrane trafficking, member of a family of enoyl-CoA hydratase/isomerases; the non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR037W	1	525437	527212	ON	4	KRS1	(525437..527212)	Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YDR038C	0	527419	530694	ON	4	ENA5	complement(527419..530694)	Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family
YDR039C	0	531304	534579	ON	4	ENA2	complement(531304..534579)	P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
YDR040C	0	535189	538464	ON	4	ENA1	complement(535189..538464)	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR041W	1	539800	540411	ON	4	RSM10	(539800..540411)	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YDR042C	0	540598	541200	ON	4	YDR042C	complement(540598..541200)	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YDR043C	0	542672	543367	ON	4	NRG1	complement(542672..543367)	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDR044W	1	546640	547626	ON	4	HEM13	(546640..547626)	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDR045C	0	547976	548308	ON	4	RPC11	complement(547976..548308)	RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YDR046C	0	548760	550574	ON	4	BAP3	complement(548760..550574)	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YDR047W	1	551858	552946	ON	4	HEM12	(551858..552946)	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YDR048C	0	553082	553396	OFF	4	YDR048C	complement(553082..553396)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR049W	1	553252	555150	ON	4	YDR049W	(553252..555150)	Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines
YDR050C	0	555724	556470	ON	4	TPI1	complement(555724..556470)	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YDR051C	0	557054	558058	ON	4	YDR051C	complement(557054..558058)	Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel
YDR052C	0	558509	560623	ON	4	DBF4	complement(558509..560623)	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
YDR053W	1	560247	560642	OFF	4	YDR053W	(560247..560642)	Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
YDR054C	0	561438	562325	ON	4	CDC34	complement(561438..562325)	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
YDR055W	1	563525	564859	ON	4	PST1	(563525..564859)	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YDR056C	0	565021	565638	ON	4	YDR056C	complement(565021..565638)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein
YDR057W	1	565925	567553	ON	4	YOS9	(565925..567553)	ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family
YDR058C	0	567721	568701	ON	4	TGL2	complement(567721..568701)	Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YDR059C	0	569232	569768	ON	4	UBC5	complement(569232..569631,569722..569768)	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YDR060W	1	570646	573723	ON	4	MAK21	(570646..573723)	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YDR061W	1	574161	575780	ON	4	YDR061W	(574161..575780)	Mitochondrial ATP-binding cassette (ABC) transporter; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
YDR062W	1	576471	578156	ON	4	LCB2	(576471..578156)	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YDR063W	1	578661	579110	ON	4	YDR063W	(578661..579110)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDR063W is not an essential gene
YDR064W	1	579456	580450	ON	4	RPS13	(579456..579476,580016..580450)	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YDR065W	1	580685	581782	ON	4	YDR065W	(580685..581782)	Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR066C	0	581906	582496	ON	4	YDR066C	complement(581906..582496)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene
YDR067C	0	582789	583463	ON	4	YDR067C	complement(582789..583463)	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR068W	1	583711	584643	ON	4	DOS2	(583711..584643)	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR069C	0	584937	587717	ON	4	DOA4	complement(584937..587717)	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
YDR070C	0	588096	588377	ON	4	YDR070C	complement(588096..588377)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR071C	0	588825	589400	ON	4	PAA1	complement(588825..589400)	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
YDR072C	0	589759	591342	ON	4	IPT1	complement(589759..591342)	Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YDR073W	1	592436	592945	ON	4	SNF11	(592436..592945)	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YDR074W	1	593890	596580	ON	4	TPS2	(593890..596580)	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YDR075W	1	597153	598079	ON	4	PPH3	(597153..598079)	Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
YDR076W	1	598465	599685	ON	4	RAD55	(598465..599685)	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YDR077W	1	600790	601806	ON	4	SED1	(600790..601806)	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YDR078C	0	602195	602866	ON	4	SHU2	complement(602195..602866)	Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p
YDR079W	1	603061	603396	ON	4	PET100	(603061..603396)	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
YDR079C-A	0	603590	603808	ON	4	TFB5	complement(603590..603808)	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation; homolog of the Chlamydomonas reinhardtii REX1-S protein which is involved in DNA repair
YDR080W	1	604005	606983	ON	4	VPS41	(604005..606983)	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YDR081C	0	607301	610078	ON	4	PDC2	complement(607301..610078)	Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
YDR082W	1	610438	611922	ON	4	STN1	(610438..611922)	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
YDR083W	1	612070	613248	ON	4	RRP8	(612070..613248)	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YDR084C	0	613402	614001	ON	4	TVP23	complement(613402..614001)	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR085C	0	614285	616147	ON	4	AFR1	complement(614285..616147)	Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
YDR086C	0	616925	617167	ON	4	SSS1	complement(616925..617167)	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YDR087C	0	617467	618303	ON	4	RRP1	complement(617467..618303)	Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YDR088C	0	618494	619642	ON	4	SLU7	complement(618494..619642)	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YDR089W	1	622109	624718	ON	4	YDR089W	(622109..624718)	Protein of unknown function; deletion confers resistance to Nickel
YDR090C	0	625063	625995	ON	4	YDR090C	complement(625063..625995)	Putative protein of unknown function
YDR091C	0	626705	628531	ON	4	RLI1	complement(626705..628531)	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YDR092W	1	629873	630602	ON	4	UBC13	(629873..629902,630171..630602)	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YDR093W	1	631279	636117	ON	4	DNF2	(631279..636117)	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YDR094W	1	635837	636172	OFF	4	YDR094W	(635837..636172)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YDR095C	0	636114	636524	OFF	4	YDR095C	complement(636114..636524)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR096W	1	637136	639820	ON	4	GIS1	(637136..639820)	JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDR097C	0	640106	643834	ON	4	MSH6	complement(640106..643834)	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
YDR098C	0	644175	645032	ON	4	GRX3	complement(644175..645032)	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YDR099W	1	653604	654425	ON	4	BMH2	(653604..654425)	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YDR100W	1	655010	655441	ON	4	TVP15	(655010..655441)	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YDR101C	0	655683	657464	ON	4	ARX1	complement(655683..657464)	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YDR102C	0	657645	657977	OFF	4	YDR102C	complement(657645..657977)	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YDR103W	1	658347	661100	ON	4	STE5	(658347..661100)	Pheromone-responsive scaffold protein; shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p, Ste7p, and Fus3p into a specific signaling complex; active oligomeric form interacts with Ste4p-Ste18p complex
YDR104C	0	661170	664907	ON	4	SPO71	complement(661170..664907)	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YDR105C	0	665346	666767	ON	4	TMS1	complement(665346..666767)	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
YDR106W	1	667001	667855	ON	4	ARP10	(667001..667855)	Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex
YDR107C	0	669013	671031	ON	4	YDR107C	complement(669013..671031)	Multispanning membrane protein of unknown function
YDR108W	1	671266	673362	ON	4	GSG1	(671266..673362)	Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication
YDR109C	0	673517	675664	ON	4	YDR109C	complement(673517..675664)	Putative kinase
YDR110W	1	676099	677799	ON	4	FOB1	(676099..677799)	Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YDR111C	0	678238	679761	ON	4	YDR111C	complement(678238..679761)	Putative alanine transaminase (glutamic pyruvic transaminase)
YDR112W	1	679541	679849	OFF	4	YDR112W	(679541..679849)	Hypothetical protein, null mutant displays increased levels of spontaneous Rad52 foci
YDR113C	0	680493	681614	ON	4	PDS1	complement(680493..681614)	Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
YDR114C	0	681921	682223	OFF	4	YDR114C	complement(681921..682223)	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YDR115W	1	682172	682489	ON	4	YDR115W	(682172..682489)	Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YDR116C	0	682721	683578	ON	4	MRPL1	complement(682721..683578)	Mitochondrial ribosomal protein of the large subunit
YDR117C	0	683943	685640	ON	4	TMA64	complement(683943..685640)	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain
YDR118W	1	685879	687837	ON	4	APC4	(685879..687837)	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDR118W-A	1	687765	687881	OFF	4	YDR118W-A	(687765..687881)	Dubious open reading frame; identified using a combination of expression profiling and mass spectrometry
YDR119W	1	688224	690530	ON	4	YDR119W	(688224..690530)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuolar membrane; YDR119W is not an essential gene
YDR119W-A	1	691011	691211	ON	4	YDR119W-A	(691011..691211)	Putative protein of unknown function
YDR120C	0	691546	693258	ON	4	TRM1	complement(691546..693258)	tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YDR121W	1	693582	694172	ON	4	DPB4	(693582..694172)	Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YDR122W	1	694697	697891	ON	4	KIN1	(694697..697891)	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YDR123C	0	698551	699465	ON	4	INO2	complement(698551..699465)	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YDR124W	1	700312	701286	ON	4	YDR124W	(700312..701286)	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
YDR125C	0	701394	702755	ON	4	ECM18	complement(701394..702755)	Protein of unknown function, similar to Rlp24p
YDR126W	1	703231	704241	ON	4	SWF1	(703231..704241)	Palmitoyltransferase that acts on the SNAREs Snc1p, Syn8p, Tlg1p and likely on all SNAREs; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
YDR127W	1	704481	709247	ON	4	ARO1	(704481..709247)	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
YDR128W	1	709546	712992	ON	4	YDR128W	(709546..712992)	Putative protein of unknown function
YDR129C	0	713337	715376	ON	4	SAC6	complement(713337..715244,715356..715376)	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YDR130C	0	715744	716619	ON	4	FIN1	complement(715744..716619)	Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent
YDR131C	0	716787	718457	ON	4	YDR131C	complement(716787..718457)	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
YDR132C	0	718813	720300	ON	4	YDR132C	complement(718813..720300)	Putative protein of unknown function
YDR133C	0	720959	721294	OFF	4	YDR133C	complement(720959..721294)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR134C	0	721068	721478	ON	4	YDR134C	complement(721068..721478)	Hypothetical protein
YDR135C	0	723001	727548	ON	4	YCF1	complement(723001..727548)	Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YDR136C	0	727708	728280	OFF	4	VPS61	complement(727708..728280)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YDR137W	1	728256	730247	ON	4	RGP1	(728256..730247)	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
YDR138W	1	730575	732833	ON	4	HPR1	(730575..732833)	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
YDR139C	0	733615	733921	ON	4	RUB1	complement(733615..733699,733773..733921)	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
YDR140W	1	734135	734800	ON	4	MTQ2	(734135..734800)	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC
YDR141C	0	734898	739994	ON	4	DOP1	complement(734898..739994)	Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR142C	0	740470	741597	ON	4	PEX7	complement(740470..741597)	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
YDR143C	0	742039	743871	ON	4	SAN1	complement(742039..743871)	Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins; san1 mutations suppress sir4, spt16, and cdc68 mutations, suggesting a role in chromatin silencing
YDR144C	0	744308	746098	ON	4	MKC7	complement(744308..746098)	GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YDR145W	1	746735	748354	ON	4	TAF12	(746735..748354)	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YDR146C	0	748610	750739	ON	4	SWI5	complement(748610..750739)	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YDR147W	1	751628	753232	ON	4	EKI1	(751628..753232)	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; also exhibits choline kinase activity
YDR148C	0	753672	755063	ON	4	KGD2	complement(753672..755063)	Dihydrolipoyl transsuccinylase, a component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA
YDR149C	0	755552	756259	OFF	4	YDR149C	complement(755552..756259)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR150W	1	755625	763871	ON	4	NUM1	(755625..763871)	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YDR151C	0	764175	765152	ON	4	CTH1	complement(764175..765152)	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
YDR152W	1	765703	766500	ON	4	GIR2	(765703..766500)	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YDR153C	0	766733	767968	ON	4	ENT5	complement(766733..767968)	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YDR154C	0	768400	768750	OFF	4	YDR154C	complement(768400..768750)	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YDR155C	0	768509	768997	ON	4	CPR1	complement(768509..768997)	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YDR156W	1	769522	769935	ON	4	RPA14	(769522..769935)	RNA polymerase I subunit A14
YDR157W	1	769928	770329	OFF	4	YDR157W	(769928..770329)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR158W	1	770354	771451	ON	4	HOM2	(770354..771451)	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YDR159W	1	771874	775779	ON	4	SAC3	(771874..775779)	Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
YDR160W	1	776160	778718	ON	4	SSY1	(776160..778718)	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YDR161W	1	779040	780203	ON	4	YDR161W	(779040..780203)	Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation
YDR162C	0	780387	781097	ON	4	NBP2	complement(780387..781097)	Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
YDR163W	1	781420	781947	ON	4	CWC15	(781420..781947)	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
YDR164C	0	782038	784212	ON	4	SEC1	complement(782038..784212)	Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
YDR165W	1	784868	786202	ON	4	TRM82	(784868..786202)	Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YDR166C	0	786303	789218	ON	4	SEC5	complement(786303..789218)	Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YDR167W	1	789446	790066	ON	4	TAF10	(789446..790066)	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YDR168W	1	790325	791845	ON	4	CDC37	(790325..791845)	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
YDR169C	0	792345	793886	ON	4	STB3	complement(792345..793886)	Protein that binds Sin3p in a two-hybrid assay
YDR169C-A	0	794571	794720	OFF	4	YDR169C-A	complement(794571..794720)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR170C	0	796190	802219	ON	4	SEC7	complement(796190..802219)	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YDR171W	1	806618	807745	ON	4	HSP42	(806618..807745)	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YDR172W	1	808321	810378	ON	4	SUP35	(808321..810378)	Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
YDR173C	0	810562	811629	ON	4	ARG82	complement(810562..811629)	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; putative nuclear lipid inositol PI3-kinase; regulates arginine-, phosphate-, and nitrogen-responsive genes
YDR174W	1	812107	812847	ON	4	HMO1	(812107..812847)	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YDR175C	0	813190	814149	ON	4	RSM24	complement(813190..814149)	Mitochondrial ribosomal protein of the small subunit
YDR176W	1	814449	816557	ON	4	NGG1	(814449..816557)	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YDR177W	1	816875	817522	ON	4	UBC1	(816875..817522)	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response
YDR178W	1	817947	818492	ON	4	SDH4	(817947..818492)	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDR179C	0	818705	819193	ON	4	CSN9	complement(818705..819193)	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YDR179W-A	1	819430	820821	ON	4	YDR179W-A	(819430..820821)	Putative protein of unknown function
YDR180W	1	821292	825773	ON	4	SCC2	(821292..825773)	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX
YDR181C	0	825907	827352	ON	4	SAS4	complement(825907..827352)	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
YDR182W	1	827579	829054	ON	4	CDC1	(827579..829054)	Putative membrane protein of unknown function involved in Mn2+ homeostasis; mutants display actin and general growth defects, heterogeneous cell cycle arrests, and pleiotropic defects in cell cycle progression and organelle distribution
YDR182W-A	1	829148	829351	OFF	4	YDR182W-A	(829148..829351)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR183W	1	829582	830274	ON	4	PLP1	(829582..830274)	Protein with a possible role in folding of beta-tubulin; has weak similarity to phosducins, which are G-protein regulators
YDR183C-A	0	830394	830651	OFF	4	YDR183C-A	complement(830394..830651)	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YDR184C	0	830626	831510	ON	4	ATC1	complement(830626..831510)	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
YDR185C	0	831931	832470	ON	4	YDR185C	complement(831931..832470)	Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YDR186C	0	832856	835489	ON	4	YDR186C	complement(832856..835489)	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR187C	0	836225	836743	OFF	4	YDR187C	complement(836225..836743)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YDR188W	1	836418	838058	ON	4	CCT6	(836418..838058)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YDR189W	1	838389	840389	ON	4	SLY1	(838389..840389)	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YDR190C	0	840601	841992	ON	4	RVB1	complement(840601..841992)	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YDR191W	1	842334	843446	ON	4	HST4	(842334..843446)	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YDR192C	0	843566	844858	ON	4	NUP42	complement(843566..844858)	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p
YDR193W	1	844551	844949	OFF	4	YDR193W	(844551..844949)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR194C	0	845949	847943	ON	4	MSS116	complement(845949..847943)	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
YDR194W-A	1	848068	848220	OFF	4	YDR194W-A	(848068..848220)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR195W	1	848596	850197	ON	4	REF2	(848596..850197)	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
YDR196C	0	850271	850996	ON	4	YDR196C	complement(850271..850996)	Putative dephospho-CoA kinase (DPCK) that catalyzes the final step in Coenzyme A biosynthesis; essential for viability; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR197W	1	851225	852394	ON	4	CBS2	(851225..852394)	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YDR198C	0	852530	853969	ON	4	RKM2	complement(852530..853969)	Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp
YDR199W	1	854172	854537	OFF	4	YDR199W	(854172..854537)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
YDR200C	0	854276	856090	ON	4	VPS64	complement(854276..856090)	Cytoplasmic protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p, Far7p, Far10p, and Far11p that is involved in pheromone-induced cell cycle arrest; also localized to the endoplasmic reticulum membrane
YDR201W	1	856314	856811	ON	4	SPC19	(856314..856811)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YDR202C	0	856895	857950	ON	4	RAV2	complement(856895..857950)	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
YDR203W	1	857679	857996	OFF	4	YDR203W	(857679..857996)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR204W	1	858134	859141	ON	4	COQ4	(858134..859141)	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
YDR205W	1	859343	861517	ON	4	MSC2	(859343..861517)	Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
YDR206W	1	862051	864705	ON	4	EBS1	(862051..864705)	Cytoplasmic protein of unknown function, involved in inhibition of translation; interacts with cap binding protein Cdc33; contains an RNA recognition motif and similarity to Est1p; mRNA abundance regulated by mRNA decay factors
YDR207C	0	865009	867519	ON	4	UME6	complement(865009..867519)	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YDR208W	1	868221	870560	ON	4	MSS4	(868221..870560)	Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YDR209C	0	871033	871446	OFF	4	YDR209C	complement(871033..871446)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
YDR210W	1	871071	871298	ON	4	YDR210W	(871071..871298)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR211W	1	884724	886862	ON	4	GCD6	(884724..886862)	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YDR212W	1	887229	888908	ON	4	TCP1	(887229..888908)	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
YDR213W	1	889748	892489	ON	4	UPC2	(889748..892489)	Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog
YDR214W	1	892872	893924	ON	4	AHA1	(892872..893924)	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
YDR215C	0	894115	894498	OFF	4	YDR215C	complement(894115..894498)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YDR216W	1	895031	899002	ON	4	ADR1	(895031..899002)	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YDR217C	0	899547	903476	ON	4	RAD9	complement(899547..903476)	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
YDR218C	0	903777	905048	ON	4	SPR28	complement(903777..905048)	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YDR219C	0	905451	906848	ON	4	MFB1	complement(905451..906848)	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
YDR220C	0	906996	907289	OFF	4	YDR220C	complement(906996..907289)	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YDR221W	1	907326	909434	ON	4	GTB1	(907326..909434)	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
YDR222W	1	910050	911297	ON	4	YDR222W	(910050..911297)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR223W	1	912095	913498	ON	4	CRF1	(912095..913498)	Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YDR224C	0	914313	914708	ON	4	HTB1	complement(914313..914708)	One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YDR225W	1	915526	915924	ON	4	HTA1	(915526..915924)	One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR226W	1	916482	917150	ON	4	ADK1	(916482..917150)	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
YDR227W	1	917567	921643	ON	4	SIR4	(917567..921643)	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
YDR228C	0	921922	923802	ON	4	PCF11	complement(921922..923802)	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YDR229W	1	924781	926142	ON	4	IVY1	(924781..926142)	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YDR230W	1	926219	926566	OFF	4	YDR230W	(926219..926566)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
YDR231C	0	926289	926906	ON	4	COX20	complement(926289..926906)	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YDR232W	1	927448	929094	ON	4	HEM1	(927448..929094)	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YDR233C	0	929466	930353	ON	4	RTN1	complement(929466..930353)	ER membrane protein that interacts with exocyst subunit Sec6p and with Yip3p; null mutant has an altered (mostly cisternal) ER morphology; has similarity to mammalian reticulon proteins and member of the RTNLA (reticulon-like A) subfamily
YDR234W	1	931125	933206	ON	4	LYS4	(931125..933206)	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
YDR235W	1	933500	935134	ON	4	PRP42	(933500..935134)	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
YDR236C	0	935232	935888	ON	4	FMN1	complement(935232..935888)	Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane
YDR237W	1	936611	937489	ON	4	MRPL7	(936611..937489)	Mitochondrial ribosomal protein of the large subunit
YDR238C	0	937891	940812	ON	4	SEC26	complement(937891..940812)	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YDR239C	0	941053	943416	ON	4	YDR239C	complement(941053..943416)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
YDR240C	0	943670	945148	ON	4	SNU56	complement(943670..945148)	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YDR241W	1	945147	945434	OFF	4	BUD26	(945147..945434)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDR242W	1	946803	948452	ON	4	AMD2	(946803..948452)	Putative amidase
YDR243C	0	948514	950280	ON	4	PRP28	complement(948514..950280)	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YDR244W	1	950559	952397	ON	4	PEX5	(950559..952397)	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
YDR245W	1	952796	953977	ON	4	MNN10	(952796..953977)	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
YDR246W	1	954284	954943	ON	4	TRS23	(954284..954943)	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
YDR246W-A	1	955129	955329	OFF	4	YDR246W-A	(955129..955329)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YDR247W	1	956009	957394	ON	4	VHS1	(956009..957394)	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YDR248C	0	957754	958335	ON	4	YDR248C	complement(957754..958335)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR249C	0	958677	959798	ON	4	YDR249C	complement(958677..959798)	Putative protein of unknown function
YDR250C	0	960082	960357	OFF	4	YDR250C	complement(960082..960357)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR251W	1	960610	963102	ON	4	PAM1	(960610..963102)	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
YDR252W	1	963408	963857	ON	4	BTT1	(963408..963857)	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex (alpha, beta1, beta3) which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides
YDR253C	0	963986	964561	ON	4	MET32	complement(963986..964561)	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p
YDR254W	1	965109	966485	ON	4	CHL4	(965109..966485)	Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
YDR255C	0	966553	967818	ON	4	RMD5	complement(966553..967818)	Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis
YDR256C	0	968129	969676	ON	4	CTA1	complement(968129..969676)	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
YDR257C	0	969986	971470	ON	4	SET7	complement(969986..971470)	Nuclear protein that contains a SET-domain, which have been shown to mediate methyltransferase activity in other proteins
YDR258C	0	971804	974239	ON	4	HSP78	complement(971804..974239)	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YDR259C	0	974627	975778	ON	4	YAP6	complement(974627..975778)	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YDR260C	0	976713	977225	ON	4	SWM1	complement(976713..977225)	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
YDR261C	0	977517	979205	ON	4	EXG2	complement(977517..979205)	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YDR262W	1	993130	993948	ON	4	YDR262W	(993130..993948)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YDR263C	0	994238	995530	ON	4	DIN7	complement(994238..995530)	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
YDR264C	0	996025	998319	ON	4	AKR1	complement(996025..998319)	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
YDR265W	1	998860	999873	ON	4	PEX10	(998860..999873)	C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to import machinery; mutations in human homolog cause various peroxisomal disorders
YDR266C	0	1000100	1002019	ON	4	YDR266C	complement(1000100..1002019)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
YDR267C	0	1002506	1003498	ON	4	CIA1	complement(1002506..1003498)	Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins
YDR268W	1	1004000	1005139	ON	4	MSW1	(1004000..1005139)	Mitochondrial tryptophanyl-tRNA synthetase
YDR269C	0	1005661	1005984	OFF	4	YDR269C	complement(1005661..1005984)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR270W	1	1005671	1008685	ON	4	CCC2	(1005671..1008685)	Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
YDR271C	0	1008391	1008762	OFF	4	YDR271C	complement(1008391..1008762)	Hypothetical protein
YDR272W	1	1009006	1009830	ON	4	GLO2	(1009006..1009830)	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
YDR273W	1	1010172	1011269	ON	4	DON1	(1010172..1011269)	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YDR274C	0	1011585	1011956	OFF	4	YDR274C	complement(1011585..1011956)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR275W	1	1012248	1012955	ON	4	BSC2	(1012248..1012955)	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YDR276C	0	1013472	1013639	ON	4	PMP3	complement(1013472..1013639)	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YDR277C	0	1014397	1015698	ON	4	MTH1	complement(1014397..1015698)	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YDR278C	0	1016997	1017314	OFF	4	YDR278C	complement(1016997..1017314)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR279W	1	1019364	1020416	ON	4	RNH202	(1019364..1020416)	Ribonuclease H2 subunit, required for RNase H2 activity
YDR280W	1	1020743	1021660	ON	4	RRP45	(1020743..1021660)	Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YDR281C	0	1022003	1022317	ON	4	PHM6	complement(1022003..1022317)	Protein of unknown function, expression is regulated by phosphate levels
YDR282C	0	1023507	1024751	ON	4	YDR282C	complement(1023507..1024751)	Putative protein of unknown function
YDR283C	0	1025066	1030045	ON	4	GCN2	complement(1025066..1030045)	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
YDR284C	0	1030546	1031415	ON	4	DPP1	complement(1030546..1031415)	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YDR285W	1	1032432	1035059	ON	4	ZIP1	(1032432..1035059)	Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
YDR286C	0	1035227	1035571	ON	4	YDR286C	complement(1035227..1035571)	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
YDR287W	1	1035991	1036869	ON	4	YDR287W	(1035991..1036869)	Inositol monophosphatase
YDR288W	1	1037191	1038102	ON	4	NSE3	(1037191..1038102)	Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth
YDR289C	0	1038276	1039505	ON	4	RTT103	complement(1038276..1039505)	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
YDR290W	1	1039366	1039695	OFF	4	YDR290W	(1039366..1039695)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
YDR291W	1	1039724	1042957	ON	4	YDR291W	(1039724..1042957)	Putative DNA helicase
YDR292C	0	1043142	1045007	ON	4	SRP101	complement(1043142..1045007)	Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YDR293C	0	1045636	1049388	ON	4	SSD1	complement(1045636..1049388)	Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
YDR294C	0	1050455	1052224	ON	4	DPL1	complement(1050455..1052224)	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
YDR295C	0	1052619	1054643	ON	4	HDA2	complement(1052619..1054643)	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
YDR296W	1	1055208	1055888	ON	4	MHR1	(1055208..1055888)	Protein involved in homologous recombination in mitochondria and in transcription regulation in nucleus; binds to activation domains of acidic activators; required for recombination-dependent mtDNA partitioning
YDR297W	1	1056547	1057596	ON	4	SUR2	(1056547..1057596)	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YDR298C	0	1058172	1058810	ON	4	ATP5	complement(1058172..1058810)	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein)
YDR299W	1	1059623	1061227	ON	4	BFR2	(1059623..1061227)	Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YDR300C	0	1061501	1062787	ON	4	PRO1	complement(1061501..1062787)	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
YDR301W	1	1063348	1067421	ON	4	CFT1	(1063348..1067421)	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YDR302W	1	1067727	1068386	ON	4	GPI11	(1067727..1068386)	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YDR303C	0	1068725	1071382	ON	4	RSC3	complement(1068725..1071382)	Component of the RSC chromatin remodeling complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YDR304C	0	1071876	1072553	ON	4	CPR5	complement(1071876..1072553)	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YDR305C	0	1072742	1073484	ON	4	HNT2	complement(1072742..1073308,1073398..1073484)	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
YDR306C	0	1073731	1075167	ON	4	YDR306C	complement(1073731..1075167)	F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YDR307W	1	1075861	1077849	ON	4	YDR307W	(1075861..1077849)	Putative protein of unknown function
YDR308C	0	1078023	1078445	ON	4	SRB7	complement(1078023..1078445)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YDR309C	0	1079044	1080195	ON	4	GIC2	complement(1079044..1080195)	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
YDR310C	0	1081124	1084312	ON	4	SUM1	complement(1081124..1084312)	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YDR311W	1	1085062	1086990	ON	4	TFB1	(1085062..1086990)	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YDR312W	1	1087578	1088939	ON	4	SSF2	(1087578..1088939)	Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family
YDR313C	0	1089216	1090076	ON	4	PIB1	complement(1089216..1090076)	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YDR314C	0	1090430	1092508	ON	4	RAD34	complement(1090430..1092508)	Protein involved in nucleotide excision repair (NER); homologous to RAD4
YDR315C	0	1092738	1093583	ON	4	IPK1	complement(1092738..1093583)	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
YDR316W	1	1093760	1095175	ON	4	OMS1	(1093760..1095175)	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
YDR317W	1	1102181	1103425	ON	4	HIM1	(1102181..1103425)	Protein of unknown function involved in DNA repair
YDR318W	1	1103755	1104944	ON	4	MCM21	(1103755..1103806,1103890..1104944)	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
YDR319C	0	1105000	1105824	ON	4	YDR319C	complement(1105000..1105824)	Putative protein of unknown function; identified as interacting with Sst2p and Hsp82p in high-throughput two-hybrid screens
YDR320C	0	1106092	1108098	ON	4	SWA2	complement(1106092..1108098)	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
YDR320C-A	0	1108277	1108495	ON	4	DAD4	complement(1108277..1108495)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR320W-B	1	1108481	1108618	OFF	4	YDR320W-B	(1108481..1108618)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A
YDR321W	1	1108699	1109844	ON	4	ASP1	(1108699..1109844)	Cytosolic L-asparaginase, involved in asparagine catabolism
YDR322W	1	1110586	1111689	ON	4	MRPL35	(1110586..1111689)	Mitochondrial ribosomal protein of the large subunit
YDR322C-A	0	1112000	1112290	ON	4	TIM11	complement(1112000..1112290)	Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric state of ATP synthase
YDR323C	0	1112477	1114024	ON	4	PEP7	complement(1112477..1114024)	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
YDR324C	0	1114430	1116760	ON	4	UTP4	complement(1114430..1116760)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR325W	1	1117121	1120228	ON	4	YCG1	(1117121..1120228)	Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex
YDR326C	0	1120604	1124920	ON	4	YSP2	complement(1120604..1124920)	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YDR327W	1	1125297	1125623	OFF	4	YDR327W	(1125297..1125623)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
YDR328C	0	1125429	1126013	ON	4	SKP1	complement(1125429..1126013)	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
YDR329C	0	1126265	1127590	ON	4	PEX3	complement(1126265..1127590)	Peroxisomal membrane protein (PMP) required required for the proper localization and stability of PMPs; interacts with Pex19p
YDR330W	1	1127867	1129369	ON	4	UBX5	(1127867..1129369)	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YDR331W	1	1129583	1130818	ON	4	GPI8	(1129583..1130818)	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YDR332W	1	1130996	1133065	ON	4	YDR332W	(1130996..1133065)	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YDR333C	0	1133255	1135426	ON	4	YDR333C	complement(1133255..1135426)	Putative protein of unknown function
YDR334W	1	1135927	1140471	ON	4	SWR1	(1135927..1140471)	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YDR335W	1	1141162	1144836	ON	4	MSN5	(1141162..1144836)	Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
YDR336W	1	1145086	1146030	ON	4	YDR336W	(1145086..1146030)	Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
YDR337W	1	1146313	1147173	ON	4	MRPS28	(1146313..1147173)	Mitochondrial ribosomal protein of the small subunit
YDR338C	0	1147373	1149460	ON	4	YDR338C	complement(1147373..1149460)	Hypothetical protein
YDR339C	0	1149945	1150514	ON	4	FCF1	complement(1149945..1150514)	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p
YDR340W	1	1150875	1151177	OFF	4	YDR340W	(1150875..1151177)	Putative protein of unknown function
YDR341C	0	1151797	1153620	ON	4	YDR341C	complement(1151797..1153620)	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR342C	0	1154210	1155922	ON	4	HXT7	complement(1154210..1155922)	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YDR343C	0	1159602	1161314	ON	4	HXT6	complement(1159602..1161314)	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YDR344C	0	1162000	1162443	OFF	4	YDR344C	complement(1162000..1162443)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR345C	0	1162951	1164654	ON	4	HXT3	complement(1162951..1164654)	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR346C	0	1167208	1168653	ON	4	SVF1	complement(1167208..1168653)	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YDR347W	1	1169172	1170137	ON	4	MRP1	(1169172..1170137)	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
YDR348C	0	1170320	1171819	ON	4	YDR348C	complement(1170320..1171819)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YDR349C	0	1172380	1174170	ON	4	YPS7	complement(1172380..1174170)	Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YDR350C	0	1176332	1178167	ON	4	ATP22	complement(1176332..1178167)	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR351W	1	1178659	1181253	ON	4	SBE2	(1178659..1181253)	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
YDR352W	1	1181794	1182747	ON	4	YDR352W	(1181794..1182747)	Putative protein of unknown function
YDR353W	1	1183292	1184251	ON	4	TRR1	(1183292..1184251)	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YDR354W	1	1184740	1185882	ON	4	TRP4	(1184740..1185882)	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YDR354C-A	0	1185132	1185275	OFF	4	YDR354C-A	complement(1185132..1185275)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR355C	0	1186060	1186362	OFF	4	YDR355C	complement(1186060..1186362)	Hypothetical protein; open reading frame overlaps 5' end of essential SPC110 gene encoding an inner plaque spindle pole body component
YDR356W	1	1186100	1188934	ON	4	SPC110	(1186100..1188934)	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
YDR357C	0	1189192	1189560	ON	4	YDR357C	complement(1189192..1189560)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR358W	1	1190052	1191725	ON	4	GGA1	(1190052..1191725)	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YDR359C	0	1191929	1194877	ON	4	EAF1	complement(1191929..1194877)	Component of the NuA4 histone acetyltransferase complex
YDR360W	1	1194591	1194977	OFF	4	OPI7	(1194591..1194977)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
YDR361C	0	1195404	1196255	ON	4	BCP1	complement(1195404..1196255)	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YDR362C	0	1196671	1198689	ON	4	TFC6	complement(1196671..1198689)	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
YDR363W	1	1199175	1200545	ON	4	ESC2	(1199175..1200545)	Protein involved in mating-type locus silencing, interacts with Sir2p; probably functions to recruit or stabilize Sir proteins
YDR363W-A	1	1202120	1202389	ON	4	SEM1	(1202120..1202389)	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YDR364C	0	1202835	1204202	ON	4	CDC40	complement(1202835..1204202)	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats
YDR365C	0	1204489	1206375	ON	4	ESF1	complement(1204489..1206375)	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YDR366C	0	1212430	1212828	OFF	4	YDR366C	complement(1212430..1212828)	Hypothetical protein
YDR367W	1	1212840	1213606	ON	4	YDR367W	(1212840..1212869,1212971..1213606)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR368W	1	1213896	1214834	ON	4	YPR1	(1213896..1214834)	2-methylbutyraldehyde reductase, may be involved in isoleucine catabolism
YDR369C	0	1215008	1217572	ON	4	XRS2	complement(1215008..1217572)	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
YDR370C	0	1217774	1219102	ON	4	YDR370C	complement(1217774..1219102)	Putative protein of unknown function
YDR371W	1	1219405	1220940	ON	4	CTS2	(1219405..1220940)	Sporulation-specific chitinase
YDR371C-A	0	1219501	1219605	OFF	4	YDR371C-A	complement(1219501..1219605)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completeley overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry
YDR372C	0	1221104	1222141	ON	4	VPS74	complement(1221104..1222141)	Non-essential protein of unknown function involved in vacuolar protein sorting; belongs to a family of cytosolic Golgi-associated proteins suggesting that it may play a role in secretion; also detected in the nucleus
YDR373W	1	1222751	1223323	ON	4	FRQ1	(1222751..1223323)	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
YDR374C	0	1223466	1224386	ON	4	YDR374C	complement(1223466..1224386)	Putative protein of unknown function
YDR374W-A	1	1224749	1225018	ON	4	YDR374W-A	(1224749..1225018)	Putative protein of unknown function
YDR375C	0	1225158	1226528	ON	4	BCS1	complement(1225158..1226528)	Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family
YDR376W	1	1226814	1228295	ON	4	ARH1	(1226814..1228295)	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
YDR377W	1	1228603	1228908	ON	4	ATP17	(1228603..1228908)	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR378C	0	1229341	1229601	ON	4	LSM6	complement(1229341..1229601)	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDR379W	1	1230159	1233188	ON	4	RGA2	(1230159..1233188)	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
YDR379C-A	0	1233270	1233509	ON	4	YDR379C-A	complement(1233270..1233509)	Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YDR380W	1	1234210	1236117	ON	4	ARO10	(1234210..1236117)	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YDR381W	1	1236550	1237996	ON	4	YRA1	(1236550..1236834,1237601..1237996)	Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YDR381C-A	0	1238304	1238842	ON	4	YDR381C-A	complement(1238304..1238622,1238817..1238842)	Protein of unknown function, localized to the mitochondrial outer membrane
YDR382W	1	1239484	1239816	ON	4	RPP2B	(1239484..1239816)	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDR383C	0	1239952	1240668	ON	4	NKP1	complement(1239952..1240668)	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YDR384C	0	1241196	1242023	ON	4	ATO3	complement(1241196..1242023)	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; member of the TC 9.B.33 YaaH family of putative transporters
YDR385W	1	1243222	1245750	ON	4	EFT2	(1243222..1245750)	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YDR386W	1	1246076	1247974	ON	4	MUS81	(1246076..1247974)	Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p
YDR387C	0	1248146	1249813	ON	4	YDR387C	complement(1248146..1249813)	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
YDR388W	1	1250178	1251626	ON	4	RVS167	(1250178..1251626)	Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
YDR389W	1	1252529	1254493	ON	4	SAC7	(1252529..1254493)	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YDR390C	0	1254929	1256839	ON	4	UBA2	complement(1254929..1256839)	Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YDR391C	0	1257350	1258048	ON	4	YDR391C	complement(1257350..1258048)	Hypothetical protein
YDR392W	1	1258688	1259701	ON	4	SPT3	(1258688..1259701)	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
YDR393W	1	1259893	1261263	ON	4	SHE9	(1259893..1261263)	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
YDR394W	1	1261673	1262959	ON	4	RPT3	(1261673..1262959)	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
YDR395W	1	1263316	1266150	ON	4	SXM1	(1263316..1266150)	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
YDR396W	1	1266287	1266787	OFF	4	YDR396W	(1266287..1266787)	Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YDR397C	0	1266358	1266890	ON	4	NCB2	complement(1266358..1266761,1266854..1266890)	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YDR398W	1	1267463	1269394	ON	4	UTP5	(1267463..1269394)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR399W	1	1270060	1270725	ON	4	HPT1	(1270060..1270725)	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YDR400W	1	1271055	1272077	ON	4	URH1	(1271055..1272077)	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in recycling pyrimidine deoxy- and ribonucleosides via the pyrimidine salvage pathway
YDR401W	1	1272215	1272778	OFF	4	YDR401W	(1272215..1272778)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR402C	0	1272226	1273695	ON	4	DIT2	complement(1272226..1273695)	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
YDR403W	1	1274594	1276204	ON	4	DIT1	(1274594..1276204)	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
YDR404C	0	1276646	1277161	ON	4	RPB7	complement(1276646..1277161)	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p
YDR405W	1	1277638	1278429	ON	4	MRP20	(1277638..1278429)	Mitochondrial ribosomal protein of the large subunit
YDR406W	1	1279202	1283791	ON	4	PDR15	(1279202..1283791)	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YDR406W-A	1	1283791	1284036	OFF	4	YDR406W-A	(1283791..1284036)	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YDR407C	0	1284061	1287930	ON	4	TRS120	complement(1284061..1287930)	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YDR408C	0	1288207	1288851	ON	4	ADE8	complement(1288207..1288851)	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YDR409W	1	1289398	1292112	ON	4	SIZ1	(1289398..1292112)	SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
YDR410C	0	1292364	1293083	ON	4	STE14	complement(1292364..1293083)	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
YDR411C	0	1293361	1294386	ON	4	DFM1	complement(1293361..1294386)	ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes
YDR412W	1	1294685	1295392	ON	4	YDR412W	(1294685..1295392)	Protein required for cell viability
YDR413C	0	1294828	1295403	OFF	4	YDR413C	complement(1294828..1295403)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
YDR414C	0	1295590	1296678	ON	4	ERD1	complement(1295590..1296678)	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YDR415C	0	1297029	1298153	ON	4	YDR415C	complement(1297029..1298153)	Putative protein of unknown function
YDR416W	1	1298424	1301003	ON	4	SYF1	(1298424..1301003)	Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein
YDR417C	0	1301547	1301918	OFF	4	YDR417C	complement(1301547..1301918)	Hypothetical protein
YDR418W	1	1301608	1302105	ON	4	RPL12B	(1301608..1302105)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YDR419W	1	1303166	1305064	ON	4	RAD30	(1303166..1305064)	DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins
YDR420W	1	1306259	1311667	ON	4	HKR1	(1306259..1311667)	Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1
YDR421W	1	1312032	1314884	ON	4	ARO80	(1312032..1314884)	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YDR422C	0	1315318	1317765	ON	4	SIP1	complement(1315318..1317765)	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
YDR423C	0	1318038	1319267	ON	4	CAD1	complement(1318038..1319267)	AP-1-like bZIP transcriptional activator involved in multiple stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins, binds consensus sequence TTACTAA; 5' UTR contains uORFs
YDR424C	0	1319379	1319833	ON	4	DYN2	complement(1319379..1319609,1319690..1319712,1319809..1319833)	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
YDR425W	1	1320056	1321933	ON	4	SNX41	(1320056..1321933)	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; forms a complex with Snx4p and Atg20p
YDR426C	0	1321621	1321998	OFF	4	YDR426C	complement(1321621..1321998)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
YDR427W	1	1322197	1323378	ON	4	RPN9	(1322197..1323378)	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
YDR428C	0	1323446	1324231	ON	4	YDR428C	complement(1323446..1324231)	Putative alpha/beta-serine hydrolase belonging to the subfamily of hormone-sensitive lipase-like hydrolases
YDR429C	0	1324469	1325293	ON	4	TIF35	complement(1324469..1325293)	Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YDR430C	0	1325493	1328462	ON	4	CYM1	complement(1325493..1328462)	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
YDR431W	1	1328382	1328693	OFF	4	YDR431W	(1328382..1328693)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR432W	1	1328775	1330019	ON	4	NPL3	(1328775..1330019)	RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
YDR433W	1	1329592	1330032	OFF	4	YDR433W	(1329592..1330032)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR434W	1	1331229	1332833	ON	4	GPI17	(1331229..1332833)	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YDR435C	0	1332975	1333961	ON	4	PPM1	complement(1332975..1333961)	Carboxyl methyl transferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
YDR436W	1	1334813	1336945	ON	4	PPZ2	(1334813..1336945)	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YDR437W	1	1337344	1337766	ON	4	GPI19	(1337344..1337766)	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P
YDR438W	1	1338266	1339378	ON	4	THI74	(1338266..1339378)	Mitochondrial transporter repressible by thiamine
YDR439W	1	1339668	1340711	ON	4	LRS4	(1339668..1340711)	Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
YDR440W	1	1342485	1344233	ON	4	DOT1	(1342485..1344233)	Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
YDR441C	0	1344509	1345054	ON	4	APT2	complement(1344509..1345054)	Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YDR442W	1	1345639	1346031	OFF	4	YDR442W	(1345639..1346031)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR443C	0	1345668	1349930	ON	4	SSN2	complement(1345668..1349930)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
YDR444W	1	1350282	1352345	ON	4	YDR444W	(1350282..1352345)	Putative protein of unknown function
YDR445C	0	1352174	1352581	OFF	4	YDR445C	complement(1352174..1352581)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR446W	1	1353717	1354625	ON	4	ECM11	(1353717..1354625)	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YDR447C	0	1354821	1355545	ON	4	RPS17B	complement(1354821..1355228,1355543..1355545)	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YDR448W	1	1356057	1357361	ON	4	ADA2	(1356057..1357361)	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YDR449C	0	1357572	1358894	ON	4	UTP6	complement(1357572..1358894)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR450W	1	1359915	1360790	ON	4	RPS18A	(1359915..1359961,1360397..1360790)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YDR451C	0	1361112	1362173	ON	4	YHP1	complement(1361112..1362173)	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YDR452W	1	1362870	1364894	ON	4	PPN1	(1362870..1364894)	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YDR453C	0	1365064	1365654	ON	4	TSA2	complement(1365064..1365654)	Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YDR454C	0	1366256	1366819	ON	4	GUK1	complement(1366256..1366819)	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YDR455C	0	1367365	1367673	OFF	4	YDR455C	complement(1367365..1367673)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
YDR456W	1	1367477	1369378	ON	4	NHX1	(1367477..1369378)	Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock
YDR457W	1	1369782	1379588	ON	4	TOM1	(1369782..1379588)	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators
YDR458C	0	1380047	1382038	ON	4	YDR458C	complement(1380047..1382038)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery
YDR459C	0	1382311	1383435	ON	4	PFA5	complement(1382311..1383435)	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
YDR460W	1	1383803	1384768	ON	4	TFB3	(1383803..1384768)	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
YDR461W	1	1385168	1385278	ON	4	MFA1	(1385168..1385278)	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
YDR461C-A	0	1385516	1385758	ON	4	YDR461C-A	complement(1385516..1385758)	Putative protein of unknown function
YDR462W	1	1386065	1386508	ON	4	MRPL28	(1386065..1386508)	Mitochondrial ribosomal protein of the large subunit
YDR463W	1	1386808	1388367	ON	4	STP1	(1386808..1388367)	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing
YDR464W	1	1388864	1393171	ON	4	SPP41	(1388864..1393171)	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
YDR464C-A	0	1392484	1392672	OFF	4	YDR464C-A	complement(1392484..1392672)	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR465C	0	1393328	1394566	ON	4	RMT2	complement(1393328..1394566)	Arginine methyltransferase; ribosomal protein L12 is a substrate
YDR466W	1	1395113	1397809	ON	4	PKH3	(1395113..1397809)	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YDR467C	0	1397575	1397901	OFF	4	YDR467C	complement(1397575..1397901)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR468C	0	1398018	1398692	ON	4	TLG1	complement(1398018..1398692)	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
YDR469W	1	1399007	1399534	ON	4	SDC1	(1399007..1399534)	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30
YDR470C	0	1399698	1401206	ON	4	UGO1	complement(1399698..1401206)	Protein of unknown function; outer membrane component of the mitochondrial fusion machinery; Ugo1p bind directly to Fzo1p and Mgm1p and thereby link these two GTPases during mitochondrial fusion
YDR471W	1	1401762	1402556	ON	4	RPL27B	(1401762..1401792,1402177..1402556)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YDR472W	1	1403314	1404165	ON	4	TRS31	(1403314..1404165)	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YDR473C	0	1404437	1405846	ON	4	PRP3	complement(1404437..1405846)	Splicing factor, component of the U4/U6-U5 snRNP complex
YDR475C	0	1407456	1410086	ON	4	JIP4	complement(1407456..1410086)	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
YDR476C	0	1410445	1411119	ON	4	YDR476C	complement(1410445..1411119)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YDR477W	1	1412365	1414266	ON	4	SNF1	(1412365..1414266)	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YDR478W	1	1414567	1415163	ON	4	SNM1	(1414567..1415163)	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YDR479C	0	1415202	1416866	ON	4	PEX29	complement(1415202..1416866)	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YDR480W	1	1417391	1418362	ON	4	DIG2	(1417391..1418362)	Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YDR481C	0	1418542	1420242	ON	4	PHO8	complement(1418542..1420242)	Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides
YDR482C	0	1420423	1420830	ON	4	CWC21	complement(1420423..1420830)	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p
YDR483W	1	1421149	1422477	ON	4	KRE2	(1421149..1422477)	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation
YDR484W	1	1422755	1424680	ON	4	VPS52	(1422755..1424680)	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
YDR485C	0	1424812	1427199	ON	4	VPS72	complement(1424812..1427199)	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YDR486C	0	1427423	1428112	ON	4	VPS60	complement(1427423..1428112)	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation
YDR487C	0	1428346	1428972	ON	4	RIB3	complement(1428346..1428972)	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
YDR488C	0	1429180	1430781	ON	4	PAC11	complement(1429180..1430781)	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
YDR489W	1	1431004	1431888	ON	4	SLD5	(1431004..1431888)	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YDR490C	0	1431960	1434260	ON	4	PKH1	complement(1431960..1434260)	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YDR491C	0	1434492	1434983	OFF	4	YDR491C	complement(1434492..1434983)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR492W	1	1434916	1435866	ON	4	IZH1	(1434916..1435866)	Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDR493W	1	1436209	1436580	ON	4	YDR493W	(1436209..1436580)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR494W	1	1436922	1438007	ON	4	RSM28	(1436922..1438007)	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
YDR495C	0	1438107	1441142	ON	4	VPS3	complement(1438107..1441142)	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
YDR496C	0	1441425	1443395	ON	4	PUF6	complement(1441425..1443395)	Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YDR497C	0	1443705	1445459	ON	4	ITR1	complement(1443705..1445459)	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YDR498C	0	1445835	1446986	ON	4	SEC20	complement(1445835..1446986)	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p
YDR499W	1	1447822	1450065	ON	4	LCD1	(1447822..1450065)	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
YDR500C	0	1450190	1450845	ON	4	RPL37B	complement(1450190..1450449,1450839..1450845)	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YDR501W	1	1451345	1452910	ON	4	PLM2	(1451345..1452910)	Protein required for partitioning of the 2-micron plasmid
YDR502C	0	1453302	1454456	ON	4	SAM2	complement(1453302..1454456)	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDR503C	0	1455034	1455858	ON	4	LPP1	complement(1455034..1455858)	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
YDR504C	0	1456303	1456686	OFF	4	SPG3	complement(1456303..1456686)	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YDR505C	0	1456687	1459212	ON	4	PSP1	complement(1456687..1459212)	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YDR506C	0	1459720	1461546	ON	4	YDR506C	complement(1459720..1461546)	Possible membrane-localized protein
YDR507C	0	1462350	1465778	ON	4	GIN4	complement(1462350..1465778)	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YDR508C	0	1466445	1468436	ON	4	GNP1	complement(1466445..1468436)	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YDR509W	1	1468218	1468565	OFF	4	YDR509W	(1468218..1468565)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR510W	1	1469392	1469697	ON	4	SMT3	(1469392..1469697)	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YDR510C-A	0	1469687	1469803	OFF	4	YDR510C-A	complement(1469687..1469803)	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR511W	1	1470009	1470410	ON	4	ACN9	(1470009..1470410)	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YDR512C	0	1470492	1471055	ON	4	EMI1	complement(1470492..1471055)	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation
YDR513W	1	1471009	1471440	ON	4	GRX2	(1471009..1471440)	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress
YDR514C	0	1471540	1472991	ON	4	YDR514C	complement(1471540..1472991)	Putative protein of unknown function
YDR515W	1	1473421	1474764	ON	4	SLF1	(1473421..1474764)	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
YDR516C	0	1474966	1476468	ON	4	EMI2	complement(1474966..1476468)	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YDR517W	1	1477231	1478349	ON	4	GRH1	(1477231..1478349)	Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YDR518W	1	1478600	1480153	ON	4	EUG1	(1478600..1480153)	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
YDR519W	1	1480417	1480824	ON	4	FPR2	(1480417..1480824)	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking
YDR520C	0	1481077	1483395	ON	4	YDR520C	complement(1481077..1483395)	Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine
YDR521W	1	1483133	1483468	OFF	4	YDR521W	(1483133..1483468)	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
YDR522C	0	1483787	1485295	ON	4	SPS2	complement(1483787..1485295)	Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component
YDR523C	0	1485558	1487030	ON	4	SPS1	complement(1485558..1487030)	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
YDR524C	0	1487534	1488982	ON	4	AGE1	complement(1487534..1488982)	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
YDR524W-C	1	1489395	1489484	OFF	4	YDR524W-C	(1489395..1489484)	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
YDR524C-B	0	1489590	1489790	ON	4	YDR524C-B	complement(1489590..1489790)	Putative protein of unknown function
YDR524C-A	0	1489863	1489982	OFF	4	YDR524C-A	complement(1489863..1489982)	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR525W	1	1489897	1490226	OFF	4	API2	(1489897..1490226)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
YDR525W-A	1	1490588	1490827	ON	4	SNA2	(1490588..1490827)	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR526C	0	1491067	1491537	OFF	4	YDR526C	complement(1491067..1491537)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR527W	1	1491086	1492405	ON	4	RBA50	(1491086..1492405)	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YDR528W	1	1494578	1495849	ON	4	HLR1	(1494578..1495849)	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YDR529C	0	1496157	1496540	ON	4	QCR7	complement(1496157..1496540)	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
YDR530C	0	1496783	1497760	ON	4	APA2	complement(1496783..1497760)	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YDR531W	1	1498224	1499327	ON	4	YDR531W	(1498224..1499327)	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YDR532C	0	1499388	1500545	ON	4	YDR532C	complement(1499388..1500545)	Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p
YDR533C	0	1501439	1502152	ON	4	HSP31	complement(1501439..1502152)	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp32p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer
YDR534C	0	1503305	1504891	ON	4	FIT1	complement(1503305..1504891)	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR535C	0	1506597	1507353	OFF	4	YDR535C	complement(1506597..1507049,1507306..1507353)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YDR536W	1	1507996	1509705	ON	4	STL1	(1507996..1509705)	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDR537C	0	1510846	1511451	OFF	4	YDR537C	complement(1510846..1511451)	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
YDR538W	1	1510892	1511620	ON	4	PAD1	(1510892..1511620)	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives
YDR539W	1	1512084	1513595	ON	4	YDR539W	(1512084..1513595)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene
YDR540C	0	1517120	1517659	ON	4	YDR540C	complement(1517120..1517659)	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YDR541C	0	1519648	1520682	ON	4	YDR541C	complement(1519648..1520682)	Putative dihydrokaempferol 4-reductase
YDR542W	1	1523234	1523596	ON	4	YDR542W	(1523234..1523596)	Hypothetical protein
YDR543C	0	1524619	1524918	OFF	4	YDR543C	complement(1524619..1524918)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR544C	0	1525080	1525508	OFF	4	YDR544C	complement(1525080..1525508)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR545W	1	1526306	1531696	ON	4	YRF1-1	(1526306..1531696)	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YDR545C-A	0	1530848	1531327	OFF	4	YDR545C-A	complement(1530848..1531327)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL077C	0	264	4097	ON	5	YEL077C	complement(264..4097)	Helicase-like protein encoded within the telomeric Y' element
YEL077W-A	1	630	1112	OFF	5	YEL077W-A	(630..1112)	Dubious open reading frame, unlike to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL076C-A	0	4185	5114	ON	5	YEL076C-A	complement(4185..4322,4602..5114)	Putative protein of unknown function
YEL076C	0	4464	5114	ON	5	YEL076C	complement(4464..5114)	Putative protein of unknown function
YEL075W-A	1	4870	5481	OFF	5	YEL075W-A	(4870..5481)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL075C	0	5345	5713	ON	5	YEL075C	complement(5345..5713)	Putative protein of unknown function
YEL074W	1	6126	6464	OFF	5	YEL074W	(6126..6464)	Hypothetical protein
YEL073C	0	7230	7553	ON	5	YEL073C	complement(7230..7553)	Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
YEL072W	1	13720	14415	ON	5	RMD6	(13720..14415)	Protein required for sporulation
YEL071W	1	16355	17845	ON	5	DLD3	(16355..17845)	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
YEL070W	1	19589	21097	ON	5	DSF1	(19589..21097)	Deletion suppressor of mpt5 mutation
YEL069C	0	21537	23231	ON	5	HXT13	complement(21537..23231)	Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
YEL068C	0	25646	25978	OFF	5	YEL068C	complement(25646..25978)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL067C	0	26189	26776	OFF	5	YEL067C	complement(26189..26776)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL066W	1	26667	27206	ON	5	HPA3	(26667..27206)	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YEL065W	1	27657	29543	ON	5	SIT1	(27657..29543)	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
YEL064C	0	29797	31239	ON	5	AVT2	complement(29797..31239)	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YEL063C	0	31694	33466	ON	5	CAN1	complement(31694..33466)	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YEL062W	1	34407	36254	ON	5	NPR2	(34407..36254)	Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin
YEL061C	0	36535	39537	ON	5	CIN8	complement(36535..39537)	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
YEL060C	0	40046	41953	ON	5	PRB1	complement(40046..41953)	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YEL059C-A	0	42400	42624	ON	5	SOM1	complement(42400..42624)	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YEL059W	1	42652	42960	OFF	5	YEL059W	(42652..42960)	Dubious open reading frame unlikely to encode a functional protein
YEL058W	1	43252	44925	ON	5	PCM1	(43252..44925)	Essential N-acetylglucosamine-phosphate mutase, a hexosephosphate mutase involved in the biosynthesis of chitin
YEL057C	0	45020	45721	ON	5	YEL057C	complement(45020..45721)	Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YEL056W	1	47168	48373	ON	5	HAT2	(47168..48373)	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YEL055C	0	48471	51539	ON	5	POL5	complement(48471..51539)	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YEL054C	0	52721	53218	ON	5	RPL12A	complement(52721..53218)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YEL053W-A	1	52908	53255	OFF	5	YEL053W-A	(52908..53255)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YEL053C	0	53901	56102	ON	5	MAK10	complement(53901..56102)	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YEL052W	1	56571	58100	ON	5	AFG1	(56571..58100)	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
YEL051W	1	58378	59148	ON	5	VMA8	(58378..59148)	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YEL050W-A	1	59549	59740	OFF	5	YEL050W-A	(59549..59740)	Dubious open reading frame unlikely to encode a functional protein, identified by fungal homology and RT-PCR
YEL050C	0	59670	60851	ON	5	RML2	complement(59670..60851)	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YEL049W	1	63728	64090	ON	5	PAU2	(63728..64090)	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YEL048C	0	64709	65167	ON	5	YEL048C	complement(64709..65167)	Putative protein of unknown function; synthetic lethal with gcs1delta
YEL047C	0	65385	66797	ON	5	YEL047C	complement(65385..66797)	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YEL046C	0	67629	68792	ON	5	GLY1	complement(67629..68792)	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YEL045C	0	68840	69265	OFF	5	YEL045C	complement(68840..69265)	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YEL044W	1	69757	70257	ON	5	IES6	(69757..70257)	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YEL043W	1	70478	73348	ON	5	YEL043W	(70478..73348)	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
YEL042W	1	73771	75327	ON	5	GDA1	(73771..75327)	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YEL041W	1	75944	77431	ON	5	YEF1	(75944..77431)	ATP-NADH kinase; phosophorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes
YEL040W	1	78053	79456	ON	5	UTR2	(78053..79456)	Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YEL039C	0	79636	79977	ON	5	CYC7	complement(79636..79977)	Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YEL038W	1	80462	81145	ON	5	UTR4	(80462..81145)	Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YEL037C	0	81407	82603	ON	5	RAD23	complement(81407..82603)	Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
YEL036C	0	83050	84552	ON	5	ANP1	complement(83050..84552)	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YEL035C	0	85045	85545	OFF	5	UTR5	complement(85045..85545)	Protein of unknown function; transcription may be regulated by Gcr1p
YEL034C-A	0	85613	86215	OFF	5	YEL034C-A	complement(85613..86215)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YEL034W	1	85676	86149	ON	5	HYP2	(85676..86149)	Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Anb1p; possible role in translation elongation; undergoes an essential hypusination modification
YEL033W	1	86179	86598	OFF	5	YEL033W	(86179..86598)	Predicted to have metabolic role based on analysis of gene networks derived from chromatin immunoprecipitation experiments, experiments on gene deletion mutants, and localization of transcription factor binding sites
YEL032W	1	86937	89852	ON	5	MCM3	(86937..89852)	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YEL032C-A	0	87040	87201	OFF	5	YEL032C-A	complement(87040..87201)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL031W	1	90258	93905	ON	5	SPF1	(90258..93905)	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YEL030C-A	0	94583	94897	OFF	5	YEL030C-A	complement(94583..94897)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL030W	1	94644	96578	ON	5	ECM10	(94644..96578)	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YEL029C	0	96858	97796	ON	5	BUD16	complement(96858..97796)	Protein involved in bud-site selection and telomere maintenance; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; has similarity to pyridoxal kinases
YEL028W	1	98668	99129	OFF	5	YEL028W	(98668..99129)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL027W	1	100769	101251	ON	5	CUP5	(100769..101251)	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YEL026W	1	101943	102323	ON	5	SNU13	(101943..102323)	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YEL025C	0	102581	106147	ON	5	YEL025C	complement(102581..106147)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YEL024W	1	107260	107907	ON	5	RIP1	(107260..107907)	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YEL023C	0	108504	110552	ON	5	YEL023C	complement(108504..110552)	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
YEL022W	1	111421	115800	ON	5	GEA2	(111421..115800)	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
YEL021W	1	116167	116970	ON	5	URA3	(116167..116970)	Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
YEL020C-B	0	117183	117380	OFF	5	YEL020C-B	complement(117183..117380)	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YEL020W-A	1	117211	117474	ON	5	TIM9	(117211..117474)	Mitochondrial intermembrane space protein, forms a complex with Mrs11p/Tim10p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YEL020C	0	118617	120299	ON	5	YEL020C	complement(118617..120299)	Hypothetical protein with low sequence identity to Pdc1p
YEL019C	0	120498	121301	ON	5	MMS21	complement(120498..121301)	SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
YEL018C-A	0	121455	121988	OFF	5	YEL018C-A	complement(121455..121988)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL018W	1	121471	122310	ON	5	EAF5	(121471..122310)	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
YEL017C-A	0	122798	122929	ON	5	PMP2	complement(122798..122929)	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1
YEL017W	1	123657	124670	ON	5	GTT3	(123657..124670)	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YEL016C	0	124737	126218	ON	5	NPP2	complement(124737..126218)	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YEL015W	1	126629	128284	ON	5	EDC3	(126629..128284)	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
YEL014C	0	128303	128608	OFF	5	YEL014C	complement(128303..128608)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL013W	1	128825	130561	ON	5	VAC8	(128825..130561)	Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YEL012W	1	131772	132551	ON	5	UBC8	(131772..131776,131900..132551)	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YEL011W	1	133120	135234	ON	5	GLC3	(133120..135234)	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YEL010W	1	136279	136629	OFF	5	YEL010W	(136279..136629)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL009C-A	0	136371	136778	OFF	5	YEL009C-A	complement(136371..136778)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL009C	0	138918	139763	ON	5	GCN4	complement(138918..139763)	Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YEL008W	1	140512	140892	OFF	5	YEL008W	(140512..140892)	Hypothetical protein predicted to be involved in metabolism
YEL008C-A	0	140726	140818	OFF	5	YEL008C-A	complement(140726..140818)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YEL007W	1	141891	143891	ON	5	YEL007W	(141891..143891)	Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YEL006W	1	144326	145333	ON	5	YEA6	(144326..145333)	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
YEL005C	0	145906	146754	ON	5	VAB2	complement(145906..146754)	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YEL004W	1	146950	147978	ON	5	YEA4	(146950..147978)	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
YEL003W	1	148175	148598	ON	5	GIM4	(148175..148193,148282..148598)	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YEL002C	0	148721	150013	ON	5	WBP1	complement(148721..150013)	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
YEL001C	0	150300	150977	ON	5	YEL001C	complement(150300..150977)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52 foci
YER001W	1	153519	155807	ON	5	MNN1	(153519..155807)	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YER002W	1	156802	157497	ON	5	NOP16	(156802..157497)	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YER003C	0	157735	159117	ON	5	PMI40	complement(157735..158993,159087..159117)	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YER004W	1	159579	160274	ON	5	YER004W	(159579..160274)	Protein of unknown function, localized to the mitochondrial outer membrane
YER005W	1	160549	162441	ON	5	YND1	(160549..162441)	Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p
YER006W	1	162722	164284	ON	5	NUG1	(162722..164284)	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YER006C-A	0	164343	164660	OFF	5	YER006C-A	complement(164343..164660)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2
YER007W	1	164526	166082	ON	5	PAC2	(164526..166082)	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YER007C-A	0	166236	166884	ON	5	TMA20	complement(166236..166770,166874..166884)	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YER008C	0	167807	171817	ON	5	SEC3	complement(167807..171817)	Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
YER009W	1	172114	172491	ON	5	NTF2	(172114..172491)	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YER010C	0	172633	173337	ON	5	YER010C	complement(172633..173337)	Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YER011W	1	175247	176011	ON	5	TIR1	(175247..176011)	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YER012W	1	177834	178430	ON	5	PRE1	(177834..178430)	20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle
YER013W	1	178840	182277	ON	5	PRP22	(178840..182277)	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
YER014W	1	182599	184218	ON	5	HEM14	(182599..184218)	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX
YER014C-A	0	183730	184699	OFF	5	BUD25	complement(183730..184168,184677..184699)	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YER015W	1	184540	186774	ON	5	FAA2	(184540..186774)	Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids
YER016W	1	188276	189310	ON	5	BIM1	(188276..189310)	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YER017C	0	189502	191787	ON	5	AFG3	complement(189502..191787)	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YER018C	0	191958	192623	ON	5	SPC25	complement(191958..192623)	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YER019W	1	192796	194229	ON	5	ISC1	(192796..194229)	Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain
YER019C-A	0	194272	194538	ON	5	SBH2	complement(194272..194538)	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YER020W	1	195167	196516	ON	5	GPA2	(195167..196516)	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YER021W	1	196947	198518	ON	5	RPN3	(196947..198518)	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YER022W	1	198811	200874	ON	5	SRB4	(198811..200874)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YER023W	1	201075	201935	ON	5	PRO3	(201075..201935)	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
YER023C-A	0	201521	201733	OFF	5	YER023C-A	complement(201521..201733)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YER024W	1	202191	204962	ON	5	YAT2	(202191..204962)	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YER025W	1	205250	206833	ON	5	GCD11	(205250..206833)	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YER026C	0	207643	208473	ON	5	CHO1	complement(207643..208473)	Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YER027C	0	208978	210231	ON	5	GAL83	complement(208978..210231)	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
YER028C	0	210691	211875	ON	5	MIG3	complement(210691..211875)	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YER029C	0	212586	213176	ON	5	SMB1	complement(212586..213176)	Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'
YER030W	1	213436	213897	ON	5	CHZ1	(213436..213897)	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif
YER031C	0	214075	214746	ON	5	YPT31	complement(214075..214746)	GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YER032W	1	215062	217692	ON	5	FIR1	(215062..217692)	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YER033C	0	218056	221286	ON	5	ZRG8	complement(218056..221286)	Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YER034W	1	221845	222402	ON	5	YER034W	(221845..222402)	Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YER035W	1	222638	223075	ON	5	EDC2	(222638..223075)	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YER036C	0	223366	225198	ON	5	ARB1	complement(223366..225198)	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YER037W	1	225888	226853	ON	5	PHM8	(225888..226853)	Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YER038C	0	226857	228251	ON	5	KRE29	complement(226857..228251)	Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YER038W-A	1	228450	228830	OFF	5	YER038W-A	(228450..228830)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YER039C	0	228455	229204	ON	5	HVG1	complement(228455..229204)	Protein of unknown function, has homology to Vrg4p
YER039C-A	0	229262	229480	OFF	5	YER039C-A	complement(229262..229480)	Putative protein of unknown function; YER039C-A is not an essential gene
YER040W	1	229794	231986	ON	5	GLN3	(229794..231986)	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
YER041W	1	232460	234739	ON	5	YEN1	(232460..234739)	Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p
YER042W	1	234936	235490	ON	5	MXR1	(234936..235490)	Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan
YER043C	0	235769	237118	ON	5	SAH1	complement(235769..237118)	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YER044C	0	237569	238015	ON	5	ERG28	complement(237569..238015)	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
YER044C-A	0	238459	239773	ON	5	MEI4	complement(238459..239622,239711..239773)	Meiosis-specific protein involved in recombination; required for chromosome synapsis; required for production of viable spores
YER045C	0	240031	241500	ON	5	ACA1	complement(240031..241500)	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YER046W	1	243179	243610	ON	5	SPO73	(243179..243610)	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YER046W-A	1	243699	244028	OFF	5	YER046W-A	(243699..244028)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER047C	0	243809	246502	ON	5	SAP1	complement(243809..246502)	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
YER048C	0	246981	248156	ON	5	CAJ1	complement(246981..248156)	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YER048W-A	1	250717	251001	ON	5	ISD11	(250717..251001)	Protein required for mitochondrial iron-sulfur cluster biosynthesis
YER049W	1	251727	253661	ON	5	TPA1	(251727..253661)	Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YER050C	0	253970	254386	ON	5	RSM18	complement(253970..254386)	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
YER051W	1	254655	256133	ON	5	JHD1	(254655..256133)	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
YER052C	0	256374	257957	ON	5	HOM3	complement(256374..257957)	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YER053C	0	258736	259638	ON	5	PIC2	complement(258736..259638)	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YER053C-A	0	260932	261045	ON	5	YER053C-A	complement(260932..261045)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YER054C	0	262051	263697	ON	5	GIP2	complement(262051..263697)	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YER055C	0	264891	265784	ON	5	HIS1	complement(264891..265784)	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YER056C	0	266511	268112	ON	5	FCY2	complement(266511..268112)	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
YER056C-A	0	269421	270183	ON	5	RPL34A	complement(269421..269749,270147..270183)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YER057C	0	270735	271124	ON	5	HMF1	complement(270735..271124)	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YER058W	1	271766	272089	ON	5	PET117	(271766..272089)	Protein required for assembly of cytochrome c oxidase
YER059W	1	272622	273884	ON	5	PCL6	(272622..273884)	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding
YER060W	1	274565	276151	ON	5	FCY21	(274565..276151)	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YER060W-A	1	276570	278162	ON	5	FCY22	(276570..278162)	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YER061C	0	278296	279624	ON	5	CEM1	complement(278296..279624)	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YER062C	0	279928	280680	ON	5	HOR2	complement(279928..280680)	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YER063W	1	281708	282364	ON	5	THO1	(281708..282364)	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YER064C	0	282703	284220	ON	5	YER064C	complement(282703..284220)	Non-essential nuclear protein; null mutation has global effects on transcription
YER065C	0	285239	286912	ON	5	ICL1	complement(285239..286912)	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YER066W	1	290240	290797	ON	5	YER066W	(290240..290797)	Putative protein of unknown function; YER066W is not an essential gene
YER066C-A	0	291701	292201	OFF	5	YER066C-A	complement(291701..292201)	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
YER067W	1	292064	292549	ON	5	YER067W	(292064..292549)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YER067C-A	0	292238	292561	OFF	5	YER067C-A	complement(292238..292561)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
YER068W	1	293048	294811	ON	5	MOT2	(293048..294811)	Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YER068C-A	0	295299	295730	OFF	5	YER068C-A	complement(295299..295730)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER069W	1	295408	297999	ON	5	ARG5,6	(295408..297999)	Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YER070W	1	298948	301614	ON	5	RNR1	(298948..301614)	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YER071C	0	301945	302325	ON	5	YER071C	complement(301945..302325)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER072W	1	302804	303193	ON	5	VTC1	(302804..303193)	Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase
YER073W	1	304027	305589	ON	5	ALD5	(304027..305589)	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YER074W	1	306319	307192	ON	5	RPS24A	(306319..306321,306788..307192)	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YER074W-A	1	307649	308119	ON	5	YOS1	(307649..307742,307845..307952,308064..308119)	Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p
YER075C	0	308409	311195	ON	5	PTP3	complement(308409..311195)	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YER076C	0	312586	313494	ON	5	YER076C	complement(312586..313494)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YER076W-A	1	313386	313733	OFF	5	YER076W-A	(313386..313733)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YER077C	0	314530	316596	ON	5	YER077C	complement(314530..316596)	Hypothetical protein
YER078C	0	316803	318338	ON	5	YER078C	complement(316803..318338)	Metallopeptidase, localized to the mitochondrial matrix
YER078W-A	1	318642	318806	OFF	5	YER078W-A	(318642..318806)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YER079W	1	318916	319548	ON	5	YER079W	(318916..319548)	Putative protein of unknown function
YER079C-A	0	319898	320236	OFF	5	YER079C-A	complement(319898..320236)	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER080W
YER080W	1	319959	321842	ON	5	YER080W	(319959..321842)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER081W	1	322682	324091	ON	5	SER3	(322682..324091)	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YER082C	0	324268	325932	ON	5	UTP7	complement(324268..325932)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YER083C	0	326170	327027	ON	5	GET2	complement(326170..327027)	Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YER084W	1	327061	327447	OFF	5	YER084W	(327061..327447)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER084W-A	1	327594	328106	OFF	5	YER084W-A	(327594..328106)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER085C	0	327615	328136	ON	5	YER085C	complement(327615..328136)	Putative protein of unknown function
YER086W	1	328473	330203	ON	5	ILV1	(328473..330203)	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YER087W	1	330572	332302	ON	5	YER087W	(330572..332302)	Protein with similarity to tRNA synthetases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER087C-A	0	331813	332364	OFF	5	YER087C-A	complement(331813..332364)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
YER087C-B	0	332578	332826	ON	5	SBH1	complement(332578..332826)	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex; homologous to Sbh2p
YER088C	0	333172	335184	ON	5	DOT6	complement(333172..335184)	Protein of unknown function, involved in telomeric gene silencing and filamentation
YER088C-A	0	335692	336015	OFF	5	YER088C-A	complement(335692..336015)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER088W-B	1	335923	336069	OFF	5	YER088W-B	(335923..336069)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER089C	0	335942	337336	ON	5	PTC2	complement(335942..337336)	Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
YER090W	1	337945	339468	ON	5	TRP2	(337945..339468)	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YER090C-A	0	338318	338407	OFF	5	YER090C-A	complement(338318..338407)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER091C	0	339860	342163	ON	5	MET6	complement(339860..342163)	Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YER091C-A	0	342386	342607	OFF	5	YER091C-A	complement(342386..342607)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER092W	1	342851	343228	ON	5	IES5	(342851..343228)	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YER093C	0	343316	347608	ON	5	TSC11	complement(343316..347608)	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
YER093C-A	0	347908	348396	ON	5	YER093C-A	complement(347908..348197,348273..348396)	Putative protein of unknown function; YER093C-A contains an intron
YER094C	0	348725	349342	ON	5	PUP3	complement(348725..349342)	Beta subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YER095W	1	349976	351178	ON	5	RAD51	(349976..351178)	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
YER096W	1	351694	353232	ON	5	SHC1	(351694..353232)	Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YER097W	1	355136	355465	OFF	5	YER097W	(355136..355465)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER098W	1	355462	357726	ON	5	UBP9	(355462..357726)	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YER099C	0	358101	359057	ON	5	PRS2	complement(358101..359057)	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YER100W	1	359558	360310	ON	5	UBC6	(359558..360310)	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway
YER101C	0	360498	361790	ON	5	AST2	complement(360498..361790)	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YER102W	1	363096	363698	ON	5	RPS8B	(363096..363698)	Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YER103W	1	364585	366513	ON	5	SSA4	(364585..366513)	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YER104W	1	366798	367424	ON	5	RTT105	(366798..367424)	Protein with a role in regulation of Ty1 transposition
YER105C	0	367834	372009	ON	5	NUP157	complement(367834..372009)	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p
YER106W	1	372322	373230	ON	5	MAM1	(372322..373230)	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YER107C	0	373444	374541	ON	5	GLE2	complement(373444..374541)	Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YER107W-A	1	374390	374710	OFF	5	YER107W-A	(374390..374710)	Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YER109C	0	375211	377610	ON	5	FLO8	complement(375211..377610)	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YER110C	0	378758	382099	ON	5	KAP123	complement(378758..382099)	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YER111C	0	382591	385872	ON	5	SWI4	complement(382591..385872)	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YER112W	1	387228	387791	ON	5	LSM4	(387228..387791)	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YER113C	0	387928	390048	ON	5	YER113C	complement(387928..390048)	Non-essential golgi localized protein of unknown function; contains niine potential transmembrane domains and has similarity to the endosomal protein, Emp70p
YER114C	0	390586	393708	ON	5	BOI2	complement(390586..393708)	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YER115C	0	394288	394863	ON	5	SPR6	complement(394288..394863)	Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
YER116C	0	395344	396168	ON	5	SLX8	complement(395344..396168)	Protein containing a RING finger domain that interacts with Hex3p; mutant phenotypes and genetic interactions suggest a role in sumoylation and in genome stability
YER117W	1	396765	397649	ON	5	RPL23B	(396765..396806,397278..397649)	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YER118C	0	397948	399051	ON	5	SHO1	complement(397948..399051)	Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YER119C	0	399492	400838	ON	5	AVT6	complement(399492..400838)	Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YER119C-A	0	400863	401234	OFF	5	YER119C-A	complement(400863..401234)	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YER120W	1	401131	401865	ON	5	SCS2	(401131..401865)	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YER121W	1	402371	402715	OFF	5	YER121W	(402371..402715)	Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YER122C	0	402867	404348	ON	5	GLO3	complement(402867..404348)	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
YER123W	1	404809	406383	ON	5	YCK3	(404809..406383)	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of the HOPS complex subunit, Vps41p; shares overlapping essential functions with Hrr25p
YER124C	0	407338	409059	ON	5	DSE1	complement(407338..409059)	Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YER125W	1	410185	412614	ON	5	RSP5	(410185..412614)	Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
YER126C	0	413390	414175	ON	5	NSA2	complement(413390..414175)	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YER127W	1	414477	415550	ON	5	LCP5	(414477..415550)	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YER128W	1	415855	416466	ON	5	YER128W	(415855..416466)	Putative protein of unknown function
YER129W	1	417277	420705	ON	5	SAK1	(417277..420705)	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YER130C	0	421111	422442	ON	5	YER130C	complement(421111..422442)	Hypothetical protein
YER131W	1	423948	424307	ON	5	RPS26B	(423948..424307)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YER132C	0	425184	430445	ON	5	PMD1	complement(425184..430445)	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
YER133W	1	432491	433954	ON	5	GLC7	(432491..432667,433193..433954)	Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YER133W-A	1	437187	437528	OFF	5	YER133W-A	(437187..437528)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YER134C	0	437263	437799	ON	5	YER134C	complement(437263..437799)	Putative protein of unknown function; non-essential gene
YER135C	0	437948	438340	OFF	5	YER135C	complement(437948..438340)	Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YER136W	1	439612	440967	ON	5	GDI1	(439612..440967)	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YER137C	0	441369	441815	ON	5	YER137C	complement(441369..441815)	Putative protein of unknown function
YER137W-A	1	441571	441876	OFF	5	YER137W-A	(441571..441876)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER138W-A	1	449470	449574	OFF	5	YER138W-A	(449470..449574)	Putative protein of unknown function
YER139C	0	450558	451238	ON	5	YER139C	complement(450558..451238)	Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YER140W	1	451560	453230	ON	5	YER140W	(451560..453230)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER141W	1	453454	454914	ON	5	COX15	(453454..454914)	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
YER142C	0	455141	456031	ON	5	MAG1	complement(455141..456031)	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
YER143W	1	456314	457600	ON	5	DDI1	(456314..457600)	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control
YER144C	0	457801	460218	ON	5	UBP5	complement(457801..460218)	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
YER145C	0	460521	461735	ON	5	FTR1	complement(460521..461735)	High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YER145C-A	0	462381	462818	OFF	5	YER145C-A	complement(462381..462818)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W
YER146W	1	462580	462861	ON	5	LSM5	(462580..462861)	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YER147C	0	462963	464837	ON	5	SCC4	complement(462963..464837)	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YER147C-A	0	465198	465608	OFF	5	YER147C-A	complement(465198..465608)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER148W	1	465298	466020	ON	5	SPT15	(465298..466020)	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YER148W-A	1	466180	466758	OFF	5	YER148W-A	(466180..466758)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER149C	0	466203	467465	ON	5	PEA2	complement(466203..467465)	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YER150W	1	468365	468811	ON	5	SPI1	(468365..468811)	GPI-anchored, serine/threonine rich cell wall protein of unknown function; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YER151C	0	469681	472419	ON	5	UBP3	complement(469681..472419)	Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
YER152C	0	472652	473983	ON	5	YER152C	complement(472652..473983)	Putative protein of unknown function; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
YER152W-A	1	473480	474046	OFF	5	YER152W-A	(473480..474046)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER153C	0	474036	474800	ON	5	PET122	complement(474036..474800)	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane
YER154W	1	475015	476223	ON	5	OXA1	(475015..476223)	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
YER155C	0	476340	482843	ON	5	BEM2	complement(476340..482843)	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
YER156C	0	483320	484336	ON	5	YER156C	complement(483320..484336)	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YER157W	1	484783	487188	ON	5	COG3	(484783..487188)	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YER158C	0	488852	490573	ON	5	YER158C	complement(488852..490573)	Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YER158W-A	1	491482	491697	OFF	5	YER158W-A	(491482..491697)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER159C	0	491525	491953	ON	5	BUR6	complement(491525..491953)	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YER161C	0	499342	500343	ON	5	SPT2	complement(499342..500343)	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
YER162C	0	500625	502889	ON	5	RAD4	complement(500625..502889)	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YER163C	0	503079	503777	ON	5	YER163C	complement(503079..503777)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YER164W	1	505387	509793	ON	5	CHD1	(505387..509793)	Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes
YER165W	1	510368	512101	ON	5	PAB1	(510368..512101)	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
YER165C-A	0	512622	512978	OFF	5	YER165C-A	complement(512622..512978)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W
YER166W	1	512739	517454	ON	5	DNF1	(512739..517454)	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YER167W	1	518211	520766	ON	5	BCK2	(518211..520766)	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YER168C	0	521024	522664	ON	5	CCA1	complement(521024..522664)	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YER169W	1	523364	525754	ON	5	RPH1	(523364..525754)	JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YER170W	1	525969	526646	ON	5	ADK2	(525969..526646)	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
YER171W	1	527077	529413	ON	5	RAD3	(527077..529413)	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein
YER172C	0	529525	536016	ON	5	BRR2	complement(529525..536016)	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
YER172C-A	0	536270	536650	OFF	5	YER172C-A	complement(536270..536650)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER173W	1	536295	538274	ON	5	RAD24	(536295..538274)	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
YER174C	0	538429	539163	ON	5	GRX4	complement(538429..539163)	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
YER175C	0	539459	540358	ON	5	TMT1	complement(539459..540358)	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
YER175W-A	1	540645	540809	OFF	5	YER175W-A	(540645..540809)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER176W	1	541685	545050	ON	5	ECM32	(541685..545050)	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
YER177W	1	545606	546409	ON	5	BMH1	(545606..546409)	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YER178W	1	546812	548074	ON	5	PDA1	(546812..548074)	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose
YER179W	1	548416	549512	ON	5	DMC1	(548416..548547,548640..549512)	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
YER180C	0	549719	550522	ON	5	ISC10	complement(549719..550522)	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
YER180C-A	0	550860	551117	ON	5	SLO1	complement(550860..551117)	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
YER181C	0	551468	551791	OFF	5	YER181C	complement(551468..551791)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
YER182W	1	552520	553254	ON	5	YER182W	(552520..553254)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER183C	0	553329	553964	ON	5	FAU1	complement(553329..553964)	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YER184C	0	556291	558675	ON	5	YER184C	complement(556291..558675)	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YER185W	1	559449	560360	ON	5	YER185W	(559449..560360)	Putative protein of unknown function; topology models predict that YER185W may encode an integral membrane protein; similar in sequence to RSB1, which is involved in sphingoid long-chain base release
YER186C	0	561700	562620	ON	5	YER186C	complement(561700..562620)	Putative protein of unknown function
YER187W	1	566225	566650	ON	5	YER187W	(566225..566650)	Putative protein of unknown function; induced in respiratory-deficient cells
YER188W	1	568035	568754	OFF	5	YER188W	(568035..568754)	Hypothetical protein
YER188C-A	0	569603	569902	OFF	5	YER188C-A	complement(569603..569902)	Putative protein of unknown function
YER189W	1	571150	571518	ON	5	YER189W	(571150..571518)	Putative protein of unknown function
YER190W	1	571475	576520	ON	5	YRF1-2	(571475..576520)	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YER190C-A	0	574799	575374	OFF	5	YER190C-A	complement(574799..575374)	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER190C-B	0	575675	576157	OFF	5	YER190C-B	complement(575675..576157)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YFL068W	1	53	535	ON	6	YFL068W	(53..535)	Putative protein of unknown function
YFL067W	1	836	1363	OFF	6	YFL067W	(836..1363)	Protein of unknown function, down-regulated at low calcium levels
YFL066C	0	1437	2615	ON	6	YFL066C	complement(1437..2615)	Helicase-like protein encoded within the telomeric Y' element
YFL065C	0	3030	3338	ON	6	YFL065C	complement(3030..3338)	Putative protein of unknown function
YFL064C	0	3322	3846	ON	6	YFL064C	complement(3322..3846)	Putative protein of unknown function
YFL063W	1	5066	5521	OFF	6	YFL063W	(5066..5521)	Dubious open reading frame, based on available experimental and comparative sequence data
YFL062W	1	6426	7565	ON	6	COS4	(6426..7565)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YFL061W	1	9545	10222	ON	6	YFL061W	(9545..10222)	Protein whose expression is induced by DNA damage
YFL060C	0	10301	10969	ON	6	SNO3	complement(10301..10969)	Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YFL059W	1	11363	12259	ON	6	SNZ3	(11363..12259)	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YFL058W	1	12929	13951	ON	6	THI5	(12929..13951)	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YFL057C	0	14305	14763	ON	6	AAD16	complement(14305..14763)	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YFL056C	0	14793	15431	ON	6	AAD6	complement(14793..15431)	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YFL055W	1	17004	18680	ON	6	AGP3	(17004..18680)	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation
YFL054C	0	20847	22787	ON	6	YFL054C	complement(20847..22787)	Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YFL053W	1	23423	25198	ON	6	DAK2	(23423..25198)	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YFL052W	1	28232	29629	ON	6	YFL052W	(28232..29629)	Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YFL051C	0	30058	30540	ON	6	YFL051C	complement(30058..30540)	Putative protein of unknown function; YFL051C is not an essential gene
YFL050C	0	33272	35848	ON	6	ALR2	complement(33272..35848)	Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YFL049W	1	36803	38674	ON	6	SWP82	(36803..38674)	Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p
YFL048C	0	38843	40180	ON	6	EMP47	complement(38843..40180)	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YFL047W	1	40421	42565	ON	6	RGD2	(40421..42565)	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p
YFL046W	1	42815	43438	ON	6	YFL046W	(42815..43438)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL045C	0	43628	44392	ON	6	SEC53	complement(43628..44392)	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YFL044C	0	44655	45560	ON	6	OTU1	complement(44655..45560)	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family
YFL042C	0	45720	47744	ON	6	YFL042C	complement(45720..47744)	Putative protein of unknown function; YFL042C is not an essential gene
YFL041W-A	1	48734	48925	OFF	6	YFL041W-A	(48734..48925)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YFL041W	1	49139	51007	ON	6	FET5	(49139..51007)	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
YFL040W	1	51350	52972	ON	6	YFL040W	(51350..52972)	Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
YFL039C	0	53260	54695	ON	6	ACT1	complement(53260..54377,54686..54695)	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YFL038C	0	55365	55985	ON	6	YPT1	complement(55365..55985)	Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YFL037W	1	56335	57708	ON	6	TUB2	(56335..57708)	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YFL036W	1	58781	62836	ON	6	RPO41	(58781..62836)	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YFL034C-B	0	63015	63992	ON	6	MOB2	complement(63015..63858,63973..63992)	Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein
YFL034C-A	0	64242	64931	ON	6	RPL22B	complement(64242..64598,64920..64931)	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
YFL034W	1	65475	68696	ON	6	YFL034W	(65475..68696)	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
YFL033C	0	69113	74425	ON	6	RIM15	complement(69113..74425)	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YFL032W	1	74870	75190	OFF	6	YFL032W	(74870..75190)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
YFL031W	1	75177	76145	ON	6	HAC1	(75177..75837,76090..76145)	bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
YFL031C-A	0	76012	76113	OFF	6	YFL031C-A	complement(76012..76113)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YFL030W	1	76829	77986	ON	6	AGX1	(76829..77986)	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YFL029C	0	78053	79159	ON	6	CAK1	complement(78053..79159)	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
YFL028C	0	79342	80211	ON	6	CAF16	complement(79342..80211)	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; putative ABC ATPase; interacts with Ssn2p, Ssn3p, and Ssn8p
YFL027C	0	80417	81910	ON	6	GYP8	complement(80417..81910)	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YFL026W	1	82578	83873	ON	6	STE2	(82578..83873)	Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YFL025C	0	84143	87232	ON	6	BST1	complement(84143..87232)	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YFL024C	0	87845	90343	ON	6	EPL1	complement(87845..90343)	Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YFL023W	1	90984	93374	ON	6	BUD27	(90984..93374)	Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by the TOR kinase; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YFL022C	0	93497	95008	ON	6	FRS2	complement(93497..95008)	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YFL021C-A	0	95759	96613	OFF	6	YFL021C-A	complement(95759..96613)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL021W	1	95964	97496	ON	6	GAT1	(95964..97496)	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YFL020C	0	99225	99593	ON	6	PAU5	complement(99225..99593)	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YFL019C	0	100246	100599	OFF	6	YFL019C	complement(100246..100599)	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YFL018C	0	101622	103121	ON	6	LPD1	complement(101622..103121)	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
YFL017W-A	1	103693	103926	ON	6	SMX2	(103693..103926)	Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YFL017C	0	103977	104456	ON	6	GNA1	complement(103977..104456)	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YFL016C	0	104695	106230	ON	6	MDJ1	complement(104695..106230)	Protein involved in folding of mitochondrially synthesized proteins in the mitochondrial matrix; localizes to the mitochondrial inner membrane; member of the DnaJ family of molecular chaperones
YFL015W-A	1	106409	106726	OFF	6	YFL015W-A	(106409..106726)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL015C	0	106463	106957	OFF	6	YFL015C	complement(106463..106957)	Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFL014W	1	107250	107579	ON	6	HSP12	(107250..107579)	Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YFL013W-A	1	107793	108596	OFF	6	YFL013W-A	(107793..108596)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YFL013C	0	107846	109924	ON	6	IES1	complement(107846..109924)	Subunit of the INO80 chromatin remodeling complex
YFL012W-A	1	109804	110178	OFF	6	YFL012W-A	(109804..110178)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C
YFL012W	1	110641	111087	ON	6	YFL012W	(110641..111087)	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YFL011W	1	112339	113979	ON	6	HXT10	(112339..113979)	Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YFL010W-A	1	114984	115268	OFF	6	AUA1	(114984..115268)	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
YFL010C	0	115102	115737	ON	6	WWM1	complement(115102..115737)	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YFL009W	1	116139	118478	ON	6	CDC4	(116139..118478)	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
YFL008W	1	119424	123101	ON	6	SMC1	(119424..123101)	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YFL007W	1	123474	129905	ON	6	BLM10	(123474..129905)	Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YFL005W	1	130329	130976	ON	6	SEC4	(130329..130976)	Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YFL004W	1	131805	134291	ON	6	VTC2	(131805..134291)	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion
YFL003C	0	134516	137152	ON	6	MSH4	complement(134516..137152)	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
YFL002C	0	145109	146929	ON	6	SPB4	complement(145109..146929)	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YFL001W	1	147126	148454	ON	6	DEG1	(147126..148454)	Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
YFR001W	1	149105	149719	ON	6	LOC1	(149105..149719)	Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YFR002W	1	150011	152530	ON	6	NIC96	(150011..152530)	Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
YFR003C	0	152652	153119	ON	6	YPI1	complement(152652..153119)	Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
YFR004W	1	153388	154308	ON	6	RPN11	(153388..154308)	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates
YFR005C	0	154522	155868	ON	6	SAD1	complement(154522..155868)	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
YFR006W	1	156139	157746	ON	6	YFR006W	(156139..157746)	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
YFR007W	1	159293	160354	ON	6	YFR007W	(159293..160354)	Putative protein of unknown function with similarity to pantothenate kinases from other organisms; YFR007W is not an essential gene
YFR008W	1	160529	161194	ON	6	FAR7	(160529..161194)	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
YFR009W	1	162482	164740	ON	6	GCN20	(162482..164740)	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YFR009W-A	1	163869	164126	OFF	6	YFR009W-A	(163869..164126)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry
YFR010W	1	165060	166559	ON	6	UBP6	(165060..166559)	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
YFR010W-A	1	166721	166909	OFF	6	YFR010W-A	(166721..166909)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry
YFR011C	0	166739	167251	ON	6	YFR011C	complement(166739..167251)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YFR011C is not an essential gene
YFR012W	1	167881	168489	ON	6	YFR012W	(167881..168489)	Putative protein of unknown function
YFR012W-A	1	169216	169302	OFF	6	YFR012W-A	(169216..169302)	Putative protein of unknown function; identified by homology
YFR013W	1	169914	172277	ON	6	IOC3	(169914..172277)	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YFR014C	0	172529	173869	ON	6	CMK1	complement(172529..173869)	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
YFR015C	0	174257	176383	ON	6	GSY1	complement(174257..176383)	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YFR016C	0	177034	180735	ON	6	YFR016C	complement(177034..180735)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YFR017C	0	182262	182849	ON	6	YFR017C	complement(182262..182849)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YFR018C	0	183119	184210	ON	6	YFR018C	complement(183119..184210)	Putative protein of unknown function
YFR019W	1	184490	191326	ON	6	FAB1	(184490..191326)	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
YFR020W	1	192726	193424	OFF	6	YFR020W	(192726..193424)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR021W	1	194800	196302	ON	6	ATG18	(194800..196302)	Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure
YFR022W	1	196821	199022	ON	6	ROG3	(196821..199022)	Protein that binds to Rsp5p, which is a hect-type ubiquitin ligase, via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant
YFR023W	1	199862	201697	ON	6	PES4	(199862..201697)	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YFR024C-A	0	201948	203421	ON	6	LSB3	complement(201948..203256,203375..203421)	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YFR025C	0	203731	204738	ON	6	HIS2	complement(203731..204738)	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YFR026C	0	205736	206245	ON	6	YFR026C	complement(205736..206245)	Putative protein of unknown function
YFR027W	1	207440	208285	ON	6	ECO1	(207440..208285)	Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1p
YFR028C	0	208401	210056	ON	6	CDC14	complement(208401..210056)	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YFR029W	1	210925	212961	ON	6	PTR3	(210925..212961)	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YFR030W	1	213300	216407	ON	6	MET10	(213300..216407)	Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YFR031C	0	216582	220094	ON	6	SMC2	complement(216582..220094)	Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer
YFR031C-A	0	220495	221406	ON	6	RPL2A	complement(220495..221255,221403..221406)	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YFR032C	0	222078	222947	ON	6	YFR032C	complement(222078..222947)	Putative protein of unknown function; transcribed during sporulation; YFR032C is not an essential gene
YFR032C-A	0	223246	223425	ON	6	RPL29	complement(223246..223425)	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
YFR032C-B	0	223698	223961	OFF	6	YFR032C-B	complement(223698..223961)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YFR033C	0	224314	224757	ON	6	QCR6	complement(224314..224757)	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YFR034C	0	225008	225946	ON	6	PHO4	complement(225008..225946)	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YFR034W-A	1	226010	226297	OFF	6	YFR034W-A	(226010..226297)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YFR035C	0	226109	226453	OFF	6	YFR035C	complement(226109..226453)	Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
Scer_YGOB_ADL119W	1	226248	226538	ON	6	ADL119W	(226248..226538)	ANNOTATED BY YGOB - 
YFR036W	1	226950	227324	ON	6	CDC26	(226950..227324)	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YFR036W-A	1	227438	228088	OFF	6	YFR036W-A	(227438..228088)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RSC8
YFR037C	0	227500	229173	ON	6	RSC8	complement(227500..229173)	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YFR038W	1	229367	231928	ON	6	YFR038W	(229367..231928)	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 foci
YFR039C	0	231999	233531	ON	6	YFR039C	complement(231999..233531)	Putative protein of unknown function; YFR039C is not an essential gene
YFR040W	1	234229	237237	ON	6	SAP155	(234229..237237)	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p
YFR041C	0	237355	238242	ON	6	ERJ5	complement(237355..238242)	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YFR042W	1	238445	239047	ON	6	YFR042W	(238445..239047)	Protein of unknown function required for cell viability; localizes to the endoplasmic reticulum membrane
YFR043C	0	239101	239814	ON	6	YFR043C	complement(239101..239814)	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YFR044C	0	239979	241424	ON	6	DUG1	complement(239979..241424)	Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YFR045W	1	241985	242986	ON	6	YFR045W	(241985..241996,242069..242986)	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YFR046C	0	243061	244146	ON	6	CNN1	complement(243061..244146)	Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.
YFR047C	0	244266	245153	ON	6	BNA6	complement(244266..245153)	Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YFR048W	1	246133	248121	ON	6	RMD8	(246133..248121)	Cytosolic protein required for sporulation
YFR049W	1	248510	248881	ON	6	YMR31	(248510..248881)	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YFR050C	0	249053	249853	ON	6	PRE4	complement(249053..249853)	20S proteasome beta-type subunit
YFR051C	0	250150	251790	ON	6	RET2	complement(250150..251790)	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YFR052W	1	252492	253316	ON	6	RPN12	(252492..253316)	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YFR052C-A	0	253416	253721	OFF	6	YFR052C-A	complement(253416..253721)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR053C	0	253579	255036	ON	6	HXK1	complement(253579..255036)	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YFR054C	0	258842	259420	OFF	6	YFR054C	complement(258842..259420)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR056C	0	263944	264312	OFF	6	YFR056C	complement(263944..264312)	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YFR055W	1	264191	265213	ON	6	YFR055W	(264191..265213)	Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52 foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR057W	1	269048	269503	OFF	6	YFR057W	(269048..269503)	Putative protein of unknown function
YGL263W	1	2790	3932	ON	7	COS12	(2790..3932)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL262W	1	5312	5839	ON	7	YGL262W	(5312..5839)	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YGL261C	0	6290	6652	ON	7	YGL261C	complement(6290..6652)	Putative protein of unknown function; mRNA expression appears to be regulated by SUT1 and UPC2
YGL260W	1	6860	7090	OFF	7	YGL260W	(6860..7090)	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
YGL259W	1	8470	8967	ON	7	YPS5	(8470..8967)	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
YGL258W-A	1	9162	9395	ON	7	YGL258W-A	(9162..9395)	Putative protein of unknown function
YGL258W	1	11110	11730	ON	7	VEL1	(11110..11730)	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YGL257C	0	12481	14157	ON	7	MNT2	complement(12481..14157)	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YGL256W	1	14910	16307	ON	7	ADH4	(14910..16307)	Alcohol dehydrogenase type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency; alcohol dehydrogenase isoenzyme IV
YGL255W	1	20978	22108	ON	7	ZRT1	(20978..22108)	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YGL254W	1	22304	23203	ON	7	FZF1	(22304..23203)	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
YGL253W	1	23935	25395	ON	7	HXK2	(23935..25395)	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YGL252C	0	25718	27484	ON	7	RTG2	complement(25718..27484)	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YGL251C	0	27921	31636	ON	7	HFM1	complement(27921..31426,31579..31636)	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity
YGL250W	1	31910	32635	ON	7	YGL250W	(31910..32635)	Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus
YGL249W	1	33098	35212	ON	7	ZIP2	(33098..35212)	Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis
YGL248W	1	35653	36762	ON	7	PDE1	(35653..36762)	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
YGL247W	1	36933	37526	ON	7	BRR6	(36933..37526)	Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores
YGL246C	0	37617	38780	ON	7	RAI1	complement(37617..38780)	Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YGL245W	1	39023	41149	ON	7	GUS1	(39023..41149)	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
YGL244W	1	41498	43174	ON	7	RTF1	(41498..43174)	Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
YGL243W	1	43307	44509	ON	7	TAD1	(43307..44509)	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
YGL242C	0	44652	45197	ON	7	YGL242C	complement(44652..45197)	Putative protein of unknown function; deletion mutant is viable
YGL241W	1	45445	48459	ON	7	KAP114	(45445..48459)	Karyopherin, responsible for nuclear import of Spt15p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
YGL240W	1	48613	49365	ON	7	DOC1	(48613..49365)	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis
YGL239C	0	49431	49745	OFF	7	YGL239C	complement(49431..49745)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1
YGL238W	1	49552	52434	ON	7	CSE1	(49552..52434)	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YGL237C	0	52731	53528	ON	7	HAP2	complement(52731..53528)	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
YGL236C	0	53787	55796	ON	7	MTO1	complement(53787..55796)	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YGL235W	1	55279	55815	OFF	7	YGL235W	(55279..55815)	Putative protein of unknown function; potential Cdc28p substrate
YGL234W	1	56482	58890	ON	7	ADE5,7	(56482..58890)	Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YGL233W	1	59122	61854	ON	7	SEC15	(59122..61854)	Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
YGL232W	1	62075	63002	ON	7	TAN1	(62075..62131,62190..63002)	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
YGL231C	0	63048	63620	ON	7	YGL231C	complement(63048..63620)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YGL230C	0	63772	64215	ON	7	YGL230C	complement(63772..64215)	Putative protein of unknown function; non-essential gene
YGL229C	0	64503	66959	ON	7	SAP4	complement(64503..66959)	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
YGL228W	1	67598	69331	ON	7	SHE10	(67598..69331)	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YGL227W	1	69671	72547	ON	7	VID30	(69671..72547)	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YGL226C-A	0	72748	73157	ON	7	OST5	complement(72748..72987,73137..73157)	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YGL226W	1	73339	73710	ON	7	YGL226W	(73339..73710)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YGL225W	1	76893	77906	ON	7	VRG4	(76893..77906)	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YGL224C	0	78014	78856	ON	7	SDT1	complement(78014..78856)	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YGL223C	0	79111	80364	ON	7	COG1	complement(79111..80364)	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGL222C	0	80658	81185	ON	7	EDC1	complement(80658..81185)	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YGL221C	0	81425	82291	ON	7	NIF3	complement(81425..82291)	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL220W	1	82373	82735	ON	7	YGL220W	(82373..82735)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YGL219C	0	82877	84256	ON	7	MDM34	complement(82877..84256)	Mitochondrial outer membrane protein, required for normal mitochondrial morphology and inheritance; localizes to dots on the mitochondrial surface near mtDNA nucleoids; interacts genetically with MDM31 and MDM32
YGL218W	1	83649	84299	OFF	7	YGL218W	(83649..84299)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
YGL217C	0	84838	85179	OFF	7	YGL217C	complement(84838..85179)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
YGL216W	1	84884	87301	ON	7	KIP3	(84884..87301)	Kinesin-related motor protein involved in mitotic spindle positioning
YGL215W	1	87980	89338	ON	7	CLG1	(87980..89338)	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
YGL214W	1	90011	90499	OFF	7	YGL214W	(90011..90499)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
YGL213C	0	90058	91251	ON	7	SKI8	complement(90058..91251)	Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses
YGL212W	1	91436	92386	ON	7	VAM7	(91436..92386)	Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
YGL211W	1	92516	93595	ON	7	NCS6	(92516..93595)	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
YGL210W	1	93797	94465	ON	7	YPT32	(93797..94465)	GTPase of the Ypt/Rab family, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YGL209W	1	95862	97010	ON	7	MIG2	(95862..97010)	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YGL208W	1	97342	98589	ON	7	SIP2	(97342..98589)	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
YGL207W	1	98973	102080	ON	7	SPT16	(98973..102080)	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
YGL206C	0	102547	107508	ON	7	CHC1	complement(102547..107508)	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YGL205W	1	108162	110408	ON	7	POX1	(108162..110408)	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YGL204C	0	111704	112009	OFF	7	YGL204C	complement(111704..112009)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL203C	0	112479	114668	ON	7	KEX1	complement(112479..114668)	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
YGL202W	1	116063	117565	ON	7	ARO8	(116063..117565)	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YGL201C	0	117858	120911	ON	7	MCM6	complement(117858..120911)	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGL200C	0	122699	123310	ON	7	EMP24	complement(122699..123310)	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YGL199C	0	123577	124047	OFF	7	YGL199C	complement(123577..124047)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
YGL198W	1	123596	124303	ON	7	YIP4	(123596..124303)	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YGL197W	1	124703	129166	ON	7	MDS3	(124703..129166)	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YGL196W	1	129888	131174	ON	7	YGL196W	(129888..131174)	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
YGL195W	1	131531	139549	ON	7	GCN1	(131531..139549)	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YGL194C-A	0	139725	139967	ON	7	YGL194C-A	complement(139725..139967)	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YGL194C	0	140374	141732	ON	7	HOS2	complement(140374..141732)	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
YGL193C	0	141922	142233	OFF	7	YGL193C	complement(141922..142233)	Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YGL192W	1	142252	144054	ON	7	IME4	(142252..144054)	Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YGL191W	1	144814	145203	ON	7	COX13	(144814..145203)	Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YGL190C	0	145815	147395	ON	7	CDC55	complement(145815..147395)	Non-essential regulatory subunit B of protein phosphatase 2A; has multiple roles in mitosis and protein biosynthesis; found in the nucleus of most cells but also at the bud neck (large-budded cells) and at the bud tip (small-budded cells)
YGL189C	0	148235	148594	ON	7	RPS26A	complement(148235..148594)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
YGL188C-A	0	148830	148970	OFF	7	YGL188C-A	complement(148830..148970)	Putative protein of unknown function
YGL188C	0	149349	149522	OFF	7	YGL188C	complement(149349..149522)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL187C	0	149710	150177	ON	7	COX4	complement(149710..150177)	Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import
YGL186C	0	151043	152782	ON	7	TPN1	complement(151043..152782)	Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YGL185C	0	153173	154312	ON	7	YGL185C	complement(153173..154312)	Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGL184C	0	154621	156018	ON	7	STR3	complement(154621..156018)	Cystathionine beta-lyase, converts cystathionine into homocysteine
YGL183C	0	156549	157291	ON	7	MND1	complement(156549..157205,157289..157291)	Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YGL182C	0	157279	157602	OFF	7	YGL182C	complement(157279..157602)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C
YGL181W	1	157912	159102	ON	7	GTS1	(157912..159102)	Protein containing a zinc-finger in the N-terminus and a long Gln-rich region in the C-terminus; regulates ultradian rhythm, cell size, cell cycle, lifespan, sporulation, heat tolerance, and multidrug transport
YGL180W	1	160071	162764	ON	7	ATG1	(160071..162764)	Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
YGL179C	0	163415	165097	ON	7	TOS3	complement(163415..165097)	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGL178W	1	167358	170577	ON	7	MPT5	(167358..167360,168001..170577)	Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YGL177W	1	167565	167912	OFF	7	YGL177W	(167565..167912)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL176C	0	171421	173085	ON	7	YGL176C	complement(171421..173085)	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
YGL175C	0	173291	174328	ON	7	SAE2	complement(173291..174328)	Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
YGL174W	1	174551	175351	ON	7	BUD13	(174551..175351)	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
YGL173C	0	175533	180119	ON	7	KEM1	complement(175533..180119)	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
YGL172W	1	180706	182124	ON	7	NUP49	(180706..182124)	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
YGL171W	1	182396	184090	ON	7	ROK1	(182396..184090)	ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
YGL170C	0	184159	185400	ON	7	SPO74	complement(184159..185400)	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YGL169W	1	186065	187345	ON	7	SUA5	(186065..187345)	Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start
YGL168W	1	187470	187802	OFF	7	HUR1	(187470..187802)	Protein required for hydroxyurea resistance; has possible roles in DNA replication and maintenance of proper telomere length
YGL167C	0	187622	190474	ON	7	PMR1	complement(187622..190474)	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YGL166W	1	191135	191812	ON	7	CUP2	(191135..191812)	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YGL165C	0	191404	191982	OFF	7	YGL165C	complement(191404..191982)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
YGL164C	0	191984	193306	ON	7	YRB30	complement(191984..193306)	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
YGL163C	0	193713	196409	ON	7	RAD54	complement(193713..196409)	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YGL162W	1	198144	199043	ON	7	SUT1	(198144..199043)	Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YGL161C	0	199216	200148	ON	7	YIP5	complement(199216..200148)	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YGL160W	1	200567	202279	ON	7	YGL160W	(200567..202279)	Putative protein of uknown function with sequence similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes, based on co-purification experiments
YGL159W	1	202727	203839	ON	7	YGL159W	(202727..203839)	Putative protein of unknown function; deletion mutant has no detectable phenotype
YGL158W	1	207038	208576	ON	7	RCK1	(207038..208576)	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YGL157W	1	209011	210054	ON	7	YGL157W	(209011..210054)	Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YGL156W	1	210421	213672	ON	7	AMS1	(210421..213672)	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YGL155W	1	214086	215216	ON	7	CDC43	(214086..215216)	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
YGL154C	0	215283	216101	ON	7	LYS5	complement(215283..216101)	Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
YGL153W	1	216278	217303	ON	7	PEX14	(216278..217303)	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
YGL152C	0	216697	217374	OFF	7	YGL152C	complement(216697..217374)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
YGL151W	1	217529	220927	ON	7	NUT1	(217529..220927)	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
YGL150C	0	221109	225578	ON	7	INO80	complement(221109..225578)	ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases
YGL149W	1	225577	225882	OFF	7	YGL149W	(225577..225882)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YGL148W	1	226404	227534	ON	7	ARO2	(226404..227534)	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YGL147C	0	227759	228334	ON	7	RPL9A	complement(227759..228334)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YGL146C	0	228756	229691	ON	7	YGL146C	complement(228756..229691)	Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YGL145W	1	230248	232353	ON	7	TIP20	(230248..232353)	Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p
YGL144C	0	232455	234512	ON	7	ROG1	complement(232455..234512)	Protein with putative serine active lipase domain
YGL143C	0	234722	235963	ON	7	MRF1	complement(234722..235963)	Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YGL142C	0	236274	238124	ON	7	GPI10	complement(236274..238124)	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
YGL141W	1	238358	241090	ON	7	HUL5	(238358..241090)	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YGL140C	0	241358	245017	ON	7	YGL140C	complement(241358..245017)	Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YGL139W	1	245721	248129	ON	7	FLC3	(245721..248129)	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YGL138C	0	248499	249536	ON	7	YGL138C	complement(248499..249536)	Putative protein of unknown function; has no significant sequence similarity to any known protein
YGL137W	1	249874	252743	ON	7	SEC27	(249874..249891,250092..252743)	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YGL136C	0	252902	253864	ON	7	MRM2	complement(252902..253864)	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
YGL135W	1	254646	255299	ON	7	RPL1B	(254646..255299)	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YGL134W	1	255668	256969	ON	7	PCL10	(255668..256969)	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YGL133W	1	257712	261506	ON	7	ITC1	(257712..261506)	Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
YGL132W	1	261585	261920	OFF	7	YGL132W	(261585..261920)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
YGL131C	0	261653	265864	ON	7	SNT2	complement(261653..265864)	DNA binding protein with similarity to the S. pombe Snt2 protein
YGL130W	1	266150	267529	ON	7	CEG1	(266150..267529)	Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YGL129C	0	267728	269194	ON	7	RSM23	complement(267728..269194)	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
YGL128C	0	269299	270150	ON	7	CWC23	complement(269299..270150)	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
YGL127C	0	270398	270781	ON	7	SOH1	complement(270398..270781)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
YGL126W	1	271003	272145	ON	7	SCS3	(271003..272145)	Protein required for inositol prototrophy, appears to be involved in the synthesis of inositol phospholipids from inositol but not in the control of inositol synthesis
YGL125W	1	272526	274328	ON	7	MET13	(272526..274328)	Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YGL124C	0	274786	276720	ON	7	MON1	complement(274786..276720)	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
YGL123W	1	277623	278387	ON	7	RPS2	(277623..278387)	Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YGL123C-A	0	277640	277870	OFF	7	YGL123C-A	complement(277640..277870)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL122C	0	278952	280529	ON	7	NAB2	complement(278952..280529)	Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
YGL121C	0	280783	281163	ON	7	GPG1	complement(280783..281163)	Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YGL120C	0	281640	283943	ON	7	PRP43	complement(281640..283943)	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YGL119W	1	284448	285953	ON	7	ABC1	(284448..285953)	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
YGL118C	0	288020	288457	OFF	7	YGL118C	complement(288020..288457)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL117W	1	288518	289315	ON	7	YGL117W	(288518..289315)	Putative protein of unknown function
YGL116W	1	289812	291644	ON	7	CDC20	(289812..291644)	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
YGL115W	1	292036	293004	ON	7	SNF4	(292036..293004)	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YGL114W	1	293463	295640	ON	7	YGL114W	(293463..295640)	Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGL113W	1	295935	297941	ON	7	SLD3	(295935..297941)	Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
YGL112C	0	298181	299731	ON	7	TAF6	complement(298181..299731)	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YGL111W	1	299981	301372	ON	7	NSA1	(299981..301372)	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YGL110C	0	301540	303414	ON	7	CUE3	complement(301540..303414)	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
YGL109W	1	303516	303839	OFF	7	YGL109W	(303516..303839)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
YGL108C	0	303652	304074	ON	7	YGL108C	complement(303652..304074)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL107C	0	304336	306276	ON	7	RMD9	complement(304336..306276)	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
YGL106W	1	306563	307012	ON	7	MLC1	(306563..307012)	Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
YGL105W	1	307440	308570	ON	7	ARC1	(307440..308570)	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YGL104C	0	308716	310176	ON	7	VPS73	complement(308716..310176)	Mitochondrial protein involved in vacuolar protein sorting; putative transporter; member of the sugar porter family
YGL103W	1	310970	311930	ON	7	RPL28	(310970..311018,311530..311930)	Ribosomal protein L29 of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YGL102C	0	311508	311936	OFF	7	YGL102C	complement(311508..311936)	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YGL101W	1	312196	312843	ON	7	YGL101W	(312196..312843)	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YGL100W	1	313237	314286	ON	7	SEH1	(313237..314286)	Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
YGL099W	1	314634	316556	ON	7	LSG1	(314634..316556)	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YGL098W	1	317345	318082	ON	7	USE1	(317345..318082)	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YGL097W	1	321785	323233	ON	7	SRM1	(321785..323233)	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YGL096W	1	325334	326164	ON	7	TOS8	(325334..326164)	Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YGL095C	0	328877	330610	ON	7	VPS45	complement(328877..330610)	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
YGL094C	0	331121	334468	ON	7	PAN2	complement(331121..334468)	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YGL093W	1	334889	337642	ON	7	SPC105	(334889..337642)	Protein required for accurate chromosome segregation, localizes to the nuclear side of the spindle pole body; forms a complex with Ydr532cp
YGL092W	1	337909	341862	ON	7	NUP145	(337909..341862)	Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p
YGL091C	0	342059	343045	ON	7	NBP35	complement(342059..343045)	Essential P-loop NTPase that functions in nuclear and cytosolic iron-sulfur (FeS) protein assembly; has a highly conserved N-terminus
YGL090W	1	343322	344587	ON	7	LIF1	(343322..344587)	Protein involved in DNA double-strand break repair; physically interacts with DNA ligase 4 (Lig4p); homologous to mammalian XRCC4 protein
YGL089C	0	344794	345156	ON	7	MF(ALPHA)2	complement(344794..345156)	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YGL088W	1	345839	346204	OFF	7	YGL088W	(345839..346204)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YGL087C	0	346409	346907	ON	7	MMS2	complement(346409..346811,346897..346907)	Protein involved in error-free postreplication DNA repair; forms a heteromeric complex with Ubc13p that has a ubiquitin-conjugating activity; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
YGL086W	1	347122	349371	ON	7	MAD1	(347122..349371)	Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
YGL085W	1	349619	350443	ON	7	YGL085W	(349619..350443)	Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YGL084C	0	350619	352301	ON	7	GUP1	complement(350619..352301)	Plasma membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases
YGL083W	1	353061	355475	ON	7	SCY1	(353061..355475)	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
YGL082W	1	355830	356975	ON	7	YGL082W	(355830..356975)	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
YGL081W	1	357380	358342	ON	7	YGL081W	(357380..358342)	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
YGL080W	1	358639	359031	ON	7	YGL080W	(358639..359031)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL079W	1	359447	360103	ON	7	YGL079W	(359447..360103)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay
YGL078C	0	360291	361862	ON	7	DBP3	complement(360291..361862)	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YGL077C	0	362228	363919	ON	7	HNM1	complement(362228..363919)	Choline transporter (permease) that also controls the uptake of nitrogen mustard; expression is co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YGL076C	0	364338	365999	ON	7	RPL7A	complement(364338..364967,365436..365529,365989..365999)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YGL075C	0	366928	368091	ON	7	MPS2	complement(366928..368091)	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
YGL074C	0	368599	368925	OFF	7	YGL074C	complement(368599..368925)	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YGL073W	1	368756	371257	ON	7	HSF1	(368756..371257)	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
YGL072C	0	371006	371365	OFF	7	YGL072C	complement(371006..371365)	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1
YGL071W	1	372015	374087	ON	7	AFT1	(372015..374087)	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YGL070C	0	374462	374830	ON	7	RPB9	complement(374462..374830)	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
YGL069C	0	375053	375517	OFF	7	YGL069C	complement(375053..375517)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YGL068W	1	375090	375674	ON	7	MNP1	(375090..375674)	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YGL067W	1	376104	377258	ON	7	NPY1	(376104..377258)	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YGL066W	1	377612	379585	ON	7	SGF73	(377612..379585)	73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
YGL065C	0	379763	381274	ON	7	ALG2	complement(379763..381274)	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YGL064C	0	381526	383211	ON	7	MRH4	complement(381526..383211)	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YGL063W	1	383657	384769	ON	7	PUS2	(383657..384769)	Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
YGL063C-A	0	384505	384654	OFF	7	YGL063C-A	complement(384505..384654)	Dubious open reading frame, unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGL062W	1	385199	388735	ON	7	PYC1	(385199..388735)	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YGL061C	0	388971	389714	ON	7	DUO1	complement(388971..389714)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YGL060W	1	390070	391995	ON	7	YBP2	(390070..391995)	Protein with a role in resistance to oxidative stress; has similarity to Ybp1p, which is involved in regulation of the transcription factor Yap1p via oxidation of specific cysteine residues
YGL059W	1	392228	393703	ON	7	YGL059W	(392228..393703)	Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL058W	1	393992	394510	ON	7	RAD6	(393992..394510)	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
YGL057C	0	394972	395835	ON	7	YGL057C	complement(394972..395835)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant exhibits a growth defect on a non-fermentable (respiratory) carbon source
YGL056C	0	396041	397624	ON	7	SDS23	complement(396041..397624)	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YGL055W	1	398631	400163	ON	7	OLE1	(398631..400163)	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YGL054C	0	400874	401290	ON	7	ERV14	complement(400874..401290)	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YGL053W	1	402592	403305	ON	7	PRM8	(402592..403305)	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
YGL052W	1	403440	403745	OFF	7	YGL052W	(403440..403745)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27
YGL051W	1	403690	404394	ON	7	MST27	(403690..404394)	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
YGL050W	1	405779	406600	ON	7	TYW3	(405779..406600)	Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YGL049C	0	406863	409607	ON	7	TIF4632	complement(406863..409607)	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p
YGL048C	0	410072	411289	ON	7	RPT6	complement(410072..411289)	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
YGL047W	1	411555	412163	ON	7	ALG13	(411555..412163)	Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases
YGL045W	1	414106	415734	ON	7	RIM8	(414106..415734)	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YGL044C	0	416150	417040	ON	7	RNA15	complement(416150..417040)	Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p
YGL043W	1	417487	418416	ON	7	DST1	(417487..418416)	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
YGL042C	0	418292	418597	OFF	7	YGL042C	complement(418292..418597)	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
YGL041C-B	0	418709	418891	OFF	7	YGL041C-B	complement(418709..418891)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YGL041C	0	418917	419231	OFF	7	YGL041C	complement(418917..419231)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL041W-A	1	419047	419295	OFF	7	YGL041W-A	(419047..419295)	Dubious open reading frame unlikely to encode a protein; partially overlaps the dubious ORF YGL041C; identified by expression profiling and mass spectrometry
YGL040C	0	419533	420561	ON	7	HEM2	complement(419533..420561)	Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YGL039W	1	423967	425013	ON	7	YGL039W	(423967..425013)	Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YGL038C	0	425368	426810	ON	7	OCH1	complement(425368..426810)	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YGL037C	0	427303	427953	ON	7	PNC1	complement(427303..427953)	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
YGL036W	1	428606	431335	ON	7	YGL036W	(428606..431335)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YGL035C	0	431553	433067	ON	7	MIG1	complement(431553..433067)	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YGL034C	0	433219	433584	OFF	7	YGL034C	complement(433219..433584)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL033W	1	435630	436356	ON	7	HOP2	(435630..435684,435755..436356)	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YGL032C	0	436575	436838	ON	7	AGA2	complement(436575..436838)	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YGL031C	0	437472	437939	ON	7	RPL24A	complement(437472..437939)	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGL030W	1	439096	439643	ON	7	RPL30	(439096..439098,439329..439643)	Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YGL029W	1	440068	440430	ON	7	CGR1	(440068..440430)	Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YGL028C	0	441286	442914	ON	7	SCW11	complement(441286..442914)	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YGL027C	0	443647	446148	ON	7	CWH41	complement(443647..446148)	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
YGL026C	0	446417	448540	ON	7	TRP5	complement(446417..448540)	Tryptophan synthase involved in tryptophan biosynthesis, regulated by the general control system of amino acid biosynthesis
YGL025C	0	448769	449962	ON	7	PGD1	complement(448769..449962)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YGL024W	1	449793	450128	OFF	7	YGL024W	(449793..450128)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C
YGL023C	0	450202	452109	ON	7	PIB2	complement(450202..452109)	Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27
YGL022W	1	452409	454565	ON	7	STT3	(452409..454565)	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
YGL021W	1	454790	457072	ON	7	ALK1	(454790..457072)	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
YGL020C	0	457168	457875	ON	7	GET1	complement(457168..457875)	Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YGL019W	1	458161	458997	ON	7	CKB1	(458161..458997)	Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
YGL018C	0	459115	459669	ON	7	JAC1	complement(459115..459669)	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YGL017W	1	459859	461370	ON	7	ATE1	(459859..461370)	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
YGL016W	1	461671	464916	ON	7	KAP122	(461671..464916)	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
YGL015C	0	465048	465440	ON	7	YGL015C	complement(465048..465440)	Hypothetical protein
YGL014W	1	466146	468812	ON	7	PUF4	(466146..468812)	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
YGL014C-A	0	466242	466403	OFF	7	YGL014C-A	complement(466242..466403)	Dubious open reading frame, unlikely to encode a functional protein; identified by expression profiling and mass spectrometry
YGL013C	0	469097	472303	ON	7	PDR1	complement(469097..472303)	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
YGL012W	1	472860	474281	ON	7	ERG4	(472860..474281)	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YGL011C	0	474494	475252	ON	7	SCL1	complement(474494..475252)	Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria
YGL010W	1	475550	476074	ON	7	YGL010W	(475550..476074)	Putative protein of unknown function; YGL010W is not an essential gene
YGL009C	0	476318	478657	ON	7	LEU1	complement(476318..478657)	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YGL008C	0	479915	482671	ON	7	PMA1	complement(479915..482671)	Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
YGL007C-A	0	482946	483032	OFF	7	YGL007C-A	complement(482946..483032)	Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; haploid deletion strain exhibits a slow-growth phenotype
YGL007W	1	483265	483642	OFF	7	BRP1	(483265..483642)	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
YGL006W-A	1	485428	485538	OFF	7	YGL006W-A	(485428..485538)	Putative protein of unknown function; identified by SAGE
YGL006W	1	485925	489446	ON	7	PMC1	(485925..489446)	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
YGL005C	0	489712	490551	ON	7	COG7	complement(489712..490551)	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGL004C	0	490707	491960	ON	7	RPN14	complement(490707..491960)	Putative non-ATPase subunit of the 19S regulatory particle of the 26S proteasome; localized to the cytoplasm
YGL003C	0	492478	494178	ON	7	CDH1	complement(492478..494178)	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
YGL002W	1	494521	495171	ON	7	ERP6	(494521..495171)	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGL001C	0	495457	496506	ON	7	ERG26	complement(495457..496506)	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YGR001C	0	497137	498038	ON	7	YGR001C	complement(497137..497369,497463..497941,498004..498038)	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YGR002C	0	498480	499910	ON	7	SWC4	complement(498480..499910)	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
YGR003W	1	500136	502370	ON	7	CUL3	(500136..502370)	Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21
YGR004W	1	502942	504330	ON	7	PEX31	(502942..504330)	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YGR005C	0	504661	505863	ON	7	TFG2	complement(504661..505863)	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
YGR006W	1	506074	506829	ON	7	PRP18	(506074..506829)	Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
YGR007W	1	506973	507944	ON	7	MUQ1	(506973..507944)	Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
YGR008C	0	508114	508368	ON	7	STF2	complement(508114..508368)	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YGR009C	0	509051	511006	ON	7	SEC9	complement(509051..511006)	t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
YGR010W	1	511549	512736	ON	7	NMA2	(511549..512736)	Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway
YGR011W	1	512501	512827	OFF	7	YGR011W	(512501..512827)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR012W	1	513163	514344	ON	7	YGR012W	(513163..514344)	Putative cysteine synthase, localized to the mitochondrial outer membrane
YGR013W	1	514558	516420	ON	7	SNU71	(514558..516420)	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
YGR014W	1	516947	520867	ON	7	MSB2	(516947..520867)	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YGR015C	0	521094	522080	ON	7	YGR015C	complement(521094..522080)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YGR016W	1	522265	522837	ON	7	YGR016W	(522265..522837)	Putative protein of unknown function
YGR017W	1	523791	524684	ON	7	YGR017W	(523791..524684)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YGR018C	0	524369	524698	OFF	7	YGR018C	complement(524369..524698)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YGR019W	1	525233	526648	ON	7	UGA1	(525233..526648)	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YGR020C	0	526977	527333	ON	7	VMA7	complement(526977..527333)	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YGR021W	1	527636	528508	ON	7	YGR021W	(527636..528508)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR022C	0	529261	529590	OFF	7	YGR022C	complement(529261..529590)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YGR023W	1	529268	530923	ON	7	MTL1	(529268..530923)	Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YGR024C	0	531887	532600	ON	7	THG1	complement(531887..532600)	tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
YGR025W	1	532643	532945	OFF	7	YGR025W	(532643..532945)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR026W	1	532989	533825	ON	7	YGR026W	(532989..533825)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR027C	0	534136	534462	ON	7	RPS25A	complement(534136..534462)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YGR028W	1	542207	543295	ON	7	MSP1	(542207..543295)	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YGR029W	1	543557	544209	ON	7	ERV1	(543557..543642,543726..544209)	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
YGR030C	0	545685	546161	ON	7	POP6	complement(545685..546161)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YGR031W	1	546445	547473	ON	7	YGR031W	(546445..547473)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR031C-A	0	546813	547304	OFF	7	YGR031C-A	complement(546813..547304)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YGR031W
YGR032W	1	548268	553955	ON	7	GSC2	(548268..553955)	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YGR033C	0	554252	554971	ON	7	TIM21	complement(554252..554971)	Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexes
YGR034W	1	555816	556676	ON	7	RPL26B	(555816..555834,556312..556676)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YGR035C	0	557076	557426	ON	7	YGR035C	complement(557076..557426)	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YGR035W-A	1	557569	557790	OFF	7	YGR035W-A	(557569..557790)	Putative protein of unknown function
YGR036C	0	558153	558872	ON	7	CAX4	complement(558153..558872)	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YGR037C	0	559735	559998	ON	7	ACB1	complement(559735..559998)	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YGR038W	1	560686	561354	ON	7	ORM1	(560686..561354)	Evolutionarily conserved protein with similarity to Orm2p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YGR039W	1	574892	575203	OFF	7	YGR039W	(574892..575203)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YGR040W	1	575402	576508	ON	7	KSS1	(575402..576508)	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YGR041W	1	577491	579134	ON	7	BUD9	(577491..579134)	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
YGR042W	1	579480	580295	ON	7	YGR042W	(579480..580295)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR043C	0	580439	581440	ON	7	YGR043C	complement(580439..581440)	Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YGR044C	0	582994	583896	ON	7	RME1	complement(582994..583896)	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
YGR045C	0	583938	584300	OFF	7	YGR045C	complement(583938..584300)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR046W	1	584899	586056	ON	7	TAM41	(584899..586056)	Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YGR047C	0	586396	589473	ON	7	TFC4	complement(586396..589473)	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
YGR048W	1	589830	590915	ON	7	UFD1	(589830..590915)	Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
YGR049W	1	591318	591881	ON	7	SCM4	(591318..591881)	Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YGR050C	0	592090	592446	OFF	7	YGR050C	complement(592090..592446)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR051C	0	592910	593233	OFF	7	YGR051C	complement(592910..593233)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YGR052W	1	593600	594709	ON	7	YGR052W	(593600..594709)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR053C	0	594990	595841	ON	7	YGR053C	complement(594990..595841)	Putative protein of unknown function
YGR054W	1	596697	598625	ON	7	YGR054W	(596697..598625)	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
YGR055W	1	599421	601145	ON	7	MUP1	(599421..601145)	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YGR056W	1	601665	604451	ON	7	RSC1	(601665..604451)	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YGR057C	0	604777	605505	ON	7	LST7	complement(604777..605505)	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YGR058W	1	606140	607147	ON	7	PEF1	(606140..607147)	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2
YGR059W	1	607567	609105	ON	7	SPR3	(607567..609105)	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YGR060W	1	610568	611497	ON	7	ERG25	(610568..611497)	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YGR061C	0	611893	615969	ON	7	ADE6	complement(611893..615969)	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YGR062C	0	616332	617282	ON	7	COX18	complement(616332..617282)	Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa
YGR063C	0	617520	617828	ON	7	SPT4	complement(617520..617828)	Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
YGR064W	1	617625	617993	OFF	7	YGR064W	(617625..617993)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
YGR065C	0	618081	619862	ON	7	VHT1	complement(618081..619862)	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YGR066C	0	620925	621803	ON	7	YGR066C	complement(620925..621803)	Putative protein of unknown function
YGR067C	0	622406	624790	ON	7	YGR067C	complement(622406..624790)	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YGR068C	0	625328	627088	ON	7	YGR068C	complement(625328..627088)	Putative protein of unknown function; YGR068C is not an essential gene.
YGR068W-A	1	626298	626393	OFF	7	YGR068W-A	(626298..626393)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C
YGR069W	1	627087	627422	OFF	7	YGR069W	(627087..627422)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR070W	1	627810	631277	ON	7	ROM1	(627810..631277)	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YGR071C	0	631485	634067	ON	7	YGR071C	complement(631485..634067)	Putative protein of unknown function; deletion mutant has increased glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGR072W	1	634308	635471	ON	7	UPF3	(634308..635471)	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
YGR073C	0	635619	635990	OFF	7	YGR073C	complement(635619..635990)	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
YGR074W	1	635716	636156	ON	7	SMD1	(635716..636156)	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1
YGR075C	0	636151	636879	ON	7	PRP38	complement(636151..636879)	Unique component of the U4/U6.U5 tri-snRNP particle, dispensable for spliceosome assembly, but required for conformational changes which lead to catalytic activation of the spliceosome
YGR076C	0	637108	637581	ON	7	MRPL25	complement(637108..637581)	Mitochondrial ribosomal protein of the large subunit
YGR077C	0	637748	639517	ON	7	PEX8	complement(637748..639517)	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
YGR078C	0	639776	640375	ON	7	PAC10	complement(639776..640375)	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
YGR079W	1	640724	641836	ON	7	YGR079W	(640724..641836)	Putative protein of unknown function; YGR079W is not an essential gene
YGR080W	1	642014	643012	ON	7	TWF1	(642014..643012)	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
YGR081C	0	643152	643784	ON	7	SLX9	complement(643152..643784)	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YGR082W	1	644048	644599	ON	7	TOM20	(644048..644599)	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
YGR083C	0	644864	646819	ON	7	GCD2	complement(644864..646819)	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YGR084C	0	647127	648146	ON	7	MRP13	complement(647127..648146)	Mitochondrial ribosomal protein of the small subunit
YGR085C	0	648387	648911	ON	7	RPL11B	complement(648387..648911)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YGR086C	0	649602	650621	ON	7	PIL1	complement(649602..650621)	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Lsp1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YGR087C	0	651294	652985	ON	7	PDC6	complement(651294..652985)	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, involved in amino acid catabolism
YGR088W	1	654638	656326	ON	7	CTT1	(654638..656326)	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YGR089W	1	656964	659774	ON	7	NNF2	(656964..659774)	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
YGR090W	1	662362	666075	ON	7	UTP22	(662362..666075)	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YGR091W	1	666345	667829	ON	7	PRP31	(666345..667829)	Splicing factor, component of the U4/U6-U5 snRNP complex
YGR092W	1	668193	669911	ON	7	DBF2	(668193..669911)	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
YGR093W	1	670392	671915	ON	7	YGR093W	(670392..671915)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGR094W	1	672190	675504	ON	7	VAS1	(672190..675504)	Mitochondrial and cytoplasmic valyl-tRNA synthetase
YGR095C	0	675675	676346	ON	7	RRP46	complement(675675..676346)	Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YGR096W	1	676625	677569	ON	7	TPC1	(676625..677569)	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
YGR097W	1	678699	682139	ON	7	ASK10	(678699..682139)	Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YGR098C	0	682570	687462	ON	7	ESP1	complement(682570..687462)	Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1p
YGR099W	1	687903	689969	ON	7	TEL2	(687903..689969)	Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
YGR100W	1	690249	693101	ON	7	MDR1	(690249..693101)	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
YGR101W	1	693367	694407	ON	7	PCP1	(693367..694407)	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YGR102C	0	694588	695139	ON	7	YGR102C	complement(694588..695139)	Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR103W	1	695421	697238	ON	7	NOP7	(695421..697238)	Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G<sub>0</sub> and the initiation of cell proliferation
YGR104C	0	697449	698372	ON	7	SRB5	complement(697449..698372)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
YGR105W	1	698603	698836	ON	7	VMA21	(698603..698836)	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YGR106C	0	698993	699790	ON	7	YGR106C	complement(698993..699790)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YGR107W	1	702671	703120	OFF	7	YGR107W	(702671..703120)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR108W	1	703640	705055	ON	7	CLB1	(703640..705055)	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR109C	0	705363	706505	ON	7	CLB6	complement(705363..706505)	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
YGR110W	1	713713	715050	ON	7	YGR110W	(713713..715050)	Putative protein of unknown function; transcription is increased in response to genotoxic stress
YGR111W	1	715832	717034	ON	7	YGR111W	(715832..717034)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR112W	1	717362	718531	ON	7	SHY1	(717362..718531)	Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster
YGR113W	1	718897	719928	ON	7	DAM1	(718897..719928)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YGR114C	0	720269	720658	OFF	7	YGR114C	complement(720269..720658)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YGR115C	0	720376	721155	OFF	7	YGR115C	complement(720376..721155)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C
YGR116W	1	720413	724768	ON	7	SPT6	(720413..724768)	Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
YGR117C	0	725053	726483	ON	7	YGR117C	complement(725053..726483)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR118W	1	726978	727735	ON	7	RPS23A	(726978..727042,727363..727735)	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YGR119C	0	728051	729676	ON	7	NUP57	complement(728051..729676)	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
YGR120C	0	730038	730826	ON	7	COG2	complement(730038..730826)	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YGR121C	0	731454	732932	ON	7	MEP1	complement(731454..732932)	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YGR121W-A	1	733417	733632	OFF	7	YGR121W-A	(733417..733632)	Putative protein of unknown function
YGR122W	1	733940	735148	ON	7	YGR122W	(733940..735148)	Putative protein of unknown function; deletion mutants do not properly process Rim101p and have decreased resistance to rapamycin; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR122C-A	0	735635	735763	OFF	7	YGR122C-A	complement(735635..735763)	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
YGR123C	0	736667	738208	ON	7	PPT1	complement(736667..738208)	Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth
YGR124W	1	739949	741667	ON	7	ASN2	(739949..741667)	Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YGR125W	1	742330	745440	ON	7	YGR125W	(742330..745440)	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR126W	1	745840	746532	ON	7	YGR126W	(745840..746532)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YGR127W	1	746803	747741	ON	7	YGR127W	(746803..747741)	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
YGR128C	0	747955	750096	ON	7	UTP8	complement(747955..750096)	Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR129W	1	750405	751052	ON	7	SYF2	(750405..751052)	Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YGR130C	0	751399	753849	ON	7	YGR130C	complement(751399..753849)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YGR131W	1	754731	755255	ON	7	YGR131W	(754731..755255)	Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YGR132C	0	755594	756457	ON	7	PHB1	complement(755594..756457)	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YGR133W	1	756901	757452	ON	7	PEX4	(756901..757452)	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
YGR134W	1	757775	761143	ON	7	CAF130	(757775..761143)	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YGR135W	1	761397	762173	ON	7	PRE9	(761397..762173)	20S proteasome beta-type subunit; the only nonessential 20S subunit
YGR136W	1	762433	763158	ON	7	LSB1	(762433..763158)	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YGR137W	1	762893	763267	OFF	7	YGR137W	(762893..763267)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR138C	0	763767	765611	ON	7	TPO2	complement(763767..765611)	Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YGR139W	1	765731	766069	OFF	7	YGR139W	(765731..766069)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR140W	1	767434	770304	ON	7	CBF2	(767434..770304)	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YGR141W	1	770574	771977	ON	7	VPS62	(770574..771977)	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
YGR142W	1	772459	773691	ON	7	BTN2	(772459..773691)	v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YGR143W	1	775198	777513	ON	7	SKN1	(775198..777513)	Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
YGR144W	1	780404	781384	ON	7	THI4	(780404..781384)	Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YGR145W	1	781772	783895	ON	7	ENP2	(781772..783895)	Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YGR146C	0	784228	784863	ON	7	YGR146C	complement(784228..784863)	Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive <i>hsf1</i> mutant
YGR146C-A	0	785281	785442	OFF	7	YGR146C-A	complement(785281..785442)	Putative protein of unknown function
YGR147C	0	786059	786925	ON	7	NAT2	complement(786059..786925)	N alpha-acetyl-transferase, transfers acetyl group from acetyl coenzyme A to the N-terminal methionine residues of proteins
YGR148C	0	787317	787784	ON	7	RPL24B	complement(787317..787784)	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGR149W	1	789036	790334	ON	7	YGR149W	(789036..790334)	Putative protein of unknown function; predicted to be an integal membrane protein
YGR150C	0	790464	793058	ON	7	YGR150C	complement(790464..793058)	Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR151C	0	794660	794995	OFF	7	YGR151C	complement(794660..794995)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YGR152C	0	794679	795497	ON	7	RSR1	complement(794679..795497)	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YGR153W	1	796097	796750	ON	7	YGR153W	(796097..796750)	Putative protein of unknown function
YGR154C	0	796803	797873	ON	7	GTO1	complement(796803..797873)	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YGR155W	1	798548	800071	ON	7	CYS4	(798548..800071)	Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YGR156W	1	800551	801828	ON	7	PTI1	(800551..801828)	Pta1p Interacting protein
YGR157W	1	802445	805054	ON	7	CHO2	(802445..805054)	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YGR158C	0	805274	806026	ON	7	MTR3	complement(805274..806026)	3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH
YGR159C	0	806417	807661	ON	7	NSR1	complement(806417..807661)	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YGR160W	1	807078	807689	OFF	7	YGR160W	(807078..807689)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR161C	0	808634	809425	ON	7	RTS3	complement(808634..809425)	Putative component of the protein phosphatase type 2A complex
YGR161W-C	1	810232	810510	OFF	7	YGR161W-C	(810232..810510)	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YGR162W	1	824064	826922	ON	7	TIF4631	(824064..826922)	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
YGR163W	1	827557	828582	ON	7	GTR2	(827557..828582)	Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD
YGR164W	1	828630	828965	OFF	7	YGR164W	(828630..828965)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR165W	1	829121	830158	ON	7	MRPS35	(829121..830158)	Mitochondrial ribosomal protein of the small subunit
YGR166W	1	830520	832202	ON	7	KRE11	(830520..832202)	Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport
YGR167W	1	832461	833162	ON	7	CLC1	(832461..833162)	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
YGR168C	0	833357	834487	ON	7	YGR168C	complement(833357..834487)	Putative protein of unknown function; YGR168C is not an essential gene
YGR169C	0	834694	835908	ON	7	PUS6	complement(834694..835908)	Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
YGR169C-A	0	836392	836670	ON	7	YGR169C-A	complement(836392..836670)	Putative protein of unknown function
YGR170W	1	837147	840563	ON	7	PSD2	(837147..840563)	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
YGR171C	0	840829	842556	ON	7	MSM1	complement(840829..842556)	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
YGR172C	0	842850	843596	ON	7	YIP1	complement(842850..843596)	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles
YGR173W	1	843859	844965	ON	7	RBG2	(843859..844965)	Protein with similarity to mammalian developmentally regulated GTP-binding protein
YGR174C	0	845898	846410	ON	7	CBP4	complement(845898..846410)	Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
YGR174W-A	1	846660	846746	OFF	7	YGR174W-A	(846660..846746)	Putative protein of unknown function
YGR175C	0	846938	848428	ON	7	ERG1	complement(846938..848428)	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YGR176W	1	848725	849072	OFF	7	YGR176W	(848725..849072)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR177C	0	848834	850441	ON	7	ATF2	complement(848834..850441)	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YGR178C	0	851052	853220	ON	7	PBP1	complement(851052..853220)	Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YGR179C	0	853680	854900	ON	7	OKP1	complement(853680..854900)	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YGR180C	0	855269	856306	ON	7	RNR4	complement(855269..856306)	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YGR181W	1	858292	858609	ON	7	TIM13	(858292..858609)	Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YGR182C	0	858556	858909	OFF	7	YGR182C	complement(858556..858909)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
YGR183C	0	859068	859481	ON	7	QCR9	complement(859068..859265,859479..859481)	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YGR184C	0	859906	865758	ON	7	UBR1	complement(859906..865758)	Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
YGR185C	0	866341	867525	ON	7	TYS1	complement(866341..867525)	Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr
YGR186W	1	867779	869986	ON	7	TFG1	(867779..869986)	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
YGR187C	0	870237	871421	ON	7	HGH1	complement(870237..871421)	Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm
YGR188C	0	872049	875114	ON	7	BUB1	complement(872049..875114)	Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
YGR189C	0	876674	878197	ON	7	CRH1	complement(876674..878197)	Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan, putative chitin transglycosidase
YGR190C	0	880301	880666	OFF	7	YGR190C	complement(880301..880666)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YGR191W	1	880425	882236	ON	7	HIP1	(880425..882236)	High-affinity histidine permease, also involved in the transport of manganese ions
YGR192C	0	882817	883815	ON	7	TDH3	complement(882817..883815)	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YGR193C	0	884514	885746	ON	7	PDX1	complement(884514..885746)	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
YGR194C	0	886078	887880	ON	7	XKS1	complement(886078..887880)	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YGR195W	1	888887	889627	ON	7	SKI6	(888887..889627)	3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YGR196C	0	889738	892191	ON	7	FYV8	complement(889738..892191)	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YGR197C	0	892502	894145	ON	7	SNG1	complement(892502..894145)	Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YGR198W	1	894698	897151	ON	7	YPP1	(894698..897151)	Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YGR199W	1	897507	899786	ON	7	PMT6	(897507..899786)	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
YGR200C	0	899909	902275	ON	7	ELP2	complement(899909..902275)	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YGR201C	0	902525	903202	ON	7	YGR201C	complement(902525..903202)	Putative protein of unknown function
YGR202C	0	903479	904753	ON	7	PCT1	complement(903479..904753)	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
YGR203W	1	905242	905688	ON	7	YGR203W	(905242..905688)	Putative protein with sequence similarity to protein tyrosine phosphatases of the CDC25-like phosphatase family; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YGR204W	1	905939	908779	ON	7	ADE3	(905939..908779)	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
YGR204C-A	0	909066	909179	OFF	7	YGR204C-A	complement(909066..909179)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR205W	1	909218	910090	ON	7	YGR205W	(909218..910090)	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases
YGR206W	1	910437	910742	ON	7	MVB12	(910437..910742)	ESCRT-I subunit necessary for the efficient transport of cargo proteins to the vacuolar lumen; deletion mutant sensitive to rapamycin and nystatin; green fluorescent protein (GFP)-fusion protein localizes to endosome
YGR207C	0	910848	911633	ON	7	YGR207C	complement(910848..911633)	Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR208W	1	911888	912817	ON	7	SER2	(911888..912817)	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YGR209C	0	912918	913232	ON	7	TRX2	complement(912918..913232)	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YGR210C	0	913508	914743	ON	7	YGR210C	complement(913508..914743)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR211W	1	915246	916706	ON	7	ZPR1	(915246..916706)	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)
YGR212W	1	917045	918451	ON	7	SLI1	(917045..918451)	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
YGR213C	0	918517	919470	ON	7	RTA1	complement(918517..919470)	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions
YGR214W	1	920580	921793	ON	7	RPS0A	(920580..920669,921125..921793)	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGR215W	1	922180	922512	ON	7	RSM27	(922180..922512)	Mitochondrial ribosomal protein of the small subunit
YGR216C	0	922638	924467	ON	7	GPI1	complement(922638..924467)	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
YGR217W	1	924699	930818	ON	7	CCH1	(924699..930818)	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
YGR218W	1	932544	935798	ON	7	CRM1	(932544..935798)	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YGR219W	1	936038	936379	OFF	7	YGR219W	(936038..936379)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
YGR220C	0	936077	936886	ON	7	MRPL9	complement(936077..936886)	Mitochondrial ribosomal protein of the large subunit
YGR221C	0	937127	938995	ON	7	TOS2	complement(937127..938995)	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p
YGR222W	1	939926	940807	ON	7	PET54	(939926..940807)	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet122p and Pet494p; also required for splicing of the COX1 intron AI5 beta; located in the mitochondrial inner membrane
YGR223C	0	940872	942218	ON	7	HSV2	complement(940872..942218)	Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
YGR224W	1	942809	944650	ON	7	AZR1	(942809..944650)	Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
YGR225W	1	945148	947022	ON	7	AMA1	(945148..946330,946424..947022)	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YGR226C	0	946795	947004	OFF	7	YGR226C	complement(946795..947004)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
YGR227W	1	947423	949000	ON	7	DIE2	(947423..949000)	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
YGR228W	1	949368	949712	OFF	7	YGR228W	(949368..949712)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
YGR229C	0	949385	950902	ON	7	SMI1	complement(949385..950902)	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YGR230W	1	951897	952310	ON	7	BNS1	(951897..952310)	Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YGR231C	0	952551	953483	ON	7	PHB2	complement(952551..953483)	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YGR232W	1	953963	954649	ON	7	NAS6	(953963..954649)	Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6
YGR233C	0	954677	958213	ON	7	PHO81	complement(954677..958213)	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YGR234W	1	959908	961107	ON	7	YHB1	(959908..961107)	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YGR235C	0	961364	962065	ON	7	YGR235C	complement(961364..962065)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR236C	0	962534	962821	ON	7	SPG1	complement(962534..962821)	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR237C	0	963303	965660	ON	7	YGR237C	complement(963303..965660)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR238C	0	966044	968692	ON	7	KEL2	complement(966044..968692)	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YGR239C	0	969192	970058	ON	7	PEX21	complement(969192..970058)	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YGR240C	0	970776	973739	ON	7	PFK1	complement(970776..973739)	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YGR240C-A	0	974582	974782	OFF	7	YGR240C-A	complement(974582..974782)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YGR241C	0	974880	976586	ON	7	YAP1802	complement(974880..976586)	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YGR242W	1	976420	976728	OFF	7	YGR242W	(976420..976728)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YGR243W	1	977341	977781	ON	7	YGR243W	(977341..977781)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR244C	0	978041	979324	ON	7	LSC2	complement(978041..979324)	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YGR245C	0	979770	982073	ON	7	SDA1	complement(979770..982073)	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YGR246C	0	982487	984277	ON	7	BRF1	complement(982487..984277)	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
YGR247W	1	984971	985690	ON	7	CPD1	(984971..985690)	Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; no detectable phenotype is conferred by null mutation or by overexpression
YGR248W	1	985977	986744	ON	7	SOL4	(985977..986744)	6-phosphogluconolactonase with similarity to Sol3p
YGR249W	1	988054	989424	ON	7	MGA1	(988054..989424)	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YGR250C	0	991181	993526	ON	7	YGR250C	complement(991181..993526)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR251W	1	995644	996234	ON	7	YGR251W	(995644..996234)	Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGR252W	1	996874	998193	ON	7	GCN5	(996874..998193)	Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
YGR253C	0	998363	999145	ON	7	PUP2	complement(998363..999145)	Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YGR254W	1	1000932	1002245	ON	7	ENO1	(1000932..1002245)	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YGR255C	0	1002528	1003967	ON	7	COQ6	complement(1002528..1003967)	Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YGR256W	1	1004630	1006108	ON	7	GND2	(1004630..1006108)	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YGR257C	0	1006211	1007311	ON	7	MTM1	complement(1006211..1007311)	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YGR258C	0	1007677	1010772	ON	7	RAD2	complement(1007677..1010772)	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YGR259C	0	1012487	1012927	OFF	7	YGR259C	complement(1012487..1012927)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YGR260W	1	1012491	1014095	ON	7	TNA1	(1012491..1014095)	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YGR261C	0	1014327	1016756	ON	7	APL6	complement(1014327..1016756)	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
YGR262C	0	1016980	1017765	ON	7	BUD32	complement(1016980..1017765)	Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
YGR263C	0	1017973	1019247	ON	7	YGR263C	complement(1017973..1019247)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YGR264C	0	1019604	1021859	ON	7	MES1	complement(1019604..1021859)	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YGR265W	1	1021654	1022064	OFF	7	YGR265W	(1021654..1022064)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGR266W	1	1022662	1024767	ON	7	YGR266W	(1022662..1024767)	Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YGR267C	0	1025010	1025741	ON	7	FOL2	complement(1025010..1025741)	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YGR268C	0	1026063	1026659	ON	7	HUA1	complement(1026063..1026659)	Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YGR269W	1	1026642	1026968	OFF	7	YGR269W	(1026642..1026968)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
YGR270W	1	1027376	1031515	ON	7	YTA7	(1027376..1031515)	Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
YGR270C-A	0	1027388	1027606	OFF	7	YGR270C-A	complement(1027388..1027606)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W
YGR271W	1	1031797	1037700	ON	7	SLH1	(1031797..1037700)	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
YGR271C-A	0	1037806	1037997	OFF	7	YGR271C-A	complement(1037806..1037997)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YGR272C	0	1038048	1038506	ON	7	YGR272C	complement(1038048..1038506)	Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR273C	0	1038720	1039244	ON	7	YGR273C	complement(1038720..1039244)	Putative protein of unknown function; deletion mutant has no readily detectable phenotype
YGR274C	0	1039901	1043101	ON	7	TAF1	complement(1039901..1043101)	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
YGR275W	1	1043282	1043755	ON	7	RTT102	(1043282..1043755)	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
YGR276C	0	1043825	1045486	ON	7	RNH70	complement(1043825..1045486)	3' exoribonuclease, required for 5S rRNA and tRNA-Arg3 maturation
YGR277C	0	1045650	1046567	ON	7	YGR277C	complement(1045650..1046567)	Putative pantetheine-phosphate adenylyltransferase (PPAT) that catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability
YGR278W	1	1046737	1048470	ON	7	CWC22	(1046737..1048470)	Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data
YGR279C	0	1048804	1049964	ON	7	SCW4	complement(1048804..1049964)	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YGR280C	0	1050916	1051731	ON	7	PXR1	complement(1050916..1051731)	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGR281W	1	1052830	1057263	ON	7	YOR1	(1052830..1057263)	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
YGR282C	0	1057789	1058730	ON	7	BGL2	complement(1057789..1058730)	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
YGR283C	0	1059021	1060046	ON	7	YGR283C	complement(1059021..1060046)	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YGR284C	0	1060664	1061596	ON	7	ERV29	complement(1060664..1061596)	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
YGR285C	0	1061858	1063159	ON	7	ZUO1	complement(1061858..1063159)	Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YGR286C	0	1063819	1064946	ON	7	BIO2	complement(1063819..1064946)	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YGR287C	0	1067228	1068997	ON	7	YGR287C	complement(1067228..1068997)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YGR288W	1	1070299	1071720	ON	7	MAL13	(1070299..1071720)	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YGR289C	0	1073969	1075819	ON	7	MAL11	complement(1073969..1075819)	Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters
YGR290W	1	1075488	1075931	OFF	7	YGR290W	(1075488..1075931)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YGR291C	0	1076289	1076510	OFF	7	YGR291C	complement(1076289..1076510)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR292W	1	1076605	1078359	ON	7	MAL12	(1076605..1078359)	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YGR293C	0	1079891	1080352	OFF	7	YGR293C	complement(1079891..1080352)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YGR294W	1	1080312	1080674	ON	7	YGR294W	(1080312..1080674)	Hypothetical protein
YGR295C	0	1081590	1082735	ON	7	COS6	complement(1081590..1082735)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR296W	1	1084870	1090597	ON	7	YRF1-3	(1084870..1084888,1085037..1090597)	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YGR296C-A	0	1088876	1089451	OFF	7	YGR296C-A	complement(1088876..1089451)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL07R
YGR296C-B	0	1089752	1090234	OFF	7	YGR296C-B	complement(1089752..1090234)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; contained completely within TEL07R
YHL050C	0	445	3310	ON	8	YHL050C	complement(445..1897,2670..3310)	Putative protein of unknown function, potential Cdc28p substrate
YHL050W-A	1	811	1293	OFF	8	YHL050W-A	(811..1293)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHL049C	0	3725	4540	ON	8	YHL049C	complement(3725..4540)	Putative protein of unknown function
YHL048C-A	0	5662	5796	OFF	8	YHL048C-A	complement(5662..5796)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHL048W	1	6400	7545	ON	8	COS8	(6400..7545)	Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response
YHL047C	0	8298	10211	ON	8	ARN2	complement(8298..10211)	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YHL046W-A	1	9979	10305	OFF	8	YHL046W-A	(9979..10305)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL046C	0	11921	12283	ON	8	YHL046C	complement(11921..12283)	Putative protein of unknown function; not an essential gene
YHL045W	1	12500	12847	OFF	8	YHL045W	(12500..12847)	Putative protein of unknown function; not an essential gene
YHL044W	1	13563	14270	ON	8	YHL044W	(13563..14270)	Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
YHL043W	1	14899	15411	ON	8	ECM34	(14899..15411)	Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YHL042W	1	15665	16117	ON	8	YHL042W	(15665..16117)	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YHL041W	1	17390	17839	OFF	8	YHL041W	(17390..17839)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YHL040C	0	19085	20968	ON	8	ARN1	complement(19085..20968)	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YHL039W	1	21780	23537	ON	8	YHL039W	(21780..23537)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHL038C	0	23614	25506	ON	8	CBP2	complement(23614..25506)	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YHL037C	0	25698	26177	OFF	8	YHL037C	complement(25698..26177)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL036W	1	26239	27879	ON	8	MUP3	(26239..27879)	Low affinity methionine permease, similar to Mup1p
YHL035C	0	27976	32754	ON	8	VMR1	complement(27976..32754)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies
YHL034W-A	1	33174	33635	OFF	8	YHL034W-A	(33174..33635)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL034C	0	33191	34075	ON	8	SBP1	complement(33191..34075)	Nucleolar single-strand nucleic acid binding protein; associates with small nuclear RNAs
YHL033C	0	35253	36023	ON	8	RPL8A	complement(35253..36023)	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YHL032C	0	36377	38506	ON	8	GUT1	complement(36377..38506)	Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YHL031C	0	38813	39484	ON	8	GOS1	complement(38813..39484)	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YHL030W-A	1	39072	39533	OFF	8	YHL030W-A	(39072..39533)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C
YHL030W	1	40082	45688	ON	8	ECM29	(40082..45688)	Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YHL029C	0	45927	47966	ON	8	YHL029C	complement(45927..47966)	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YHL028W	1	48761	50578	ON	8	WSC4	(48761..50578)	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YHL027W	1	51109	52986	ON	8	RIM101	(51109..52986)	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
YHL026C	0	53217	54164	ON	8	YHL026C	complement(53217..54164)	Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YHL025W	1	54849	55847	ON	8	SNF6	(54849..55847)	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YHL024W	1	56647	58788	ON	8	RIM4	(56647..58788)	Putative RNA-binding protein required for the expression of early and middle sporulation genes
YHL023C	0	59121	62561	ON	8	RMD11	complement(59121..62561)	Protein required for sporulation
YHL022C	0	62959	64155	ON	8	SPO11	complement(62959..64155)	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
YHL021C	0	64459	65856	ON	8	YHL021C	complement(64459..65856)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL020C	0	66239	67453	ON	8	OPI1	complement(66239..67453)	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YHL019W-A	1	67708	68301	OFF	8	YHL019W-A	(67708..68301)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C
YHL019C	0	67728	69545	ON	8	APM2	complement(67728..69545)	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
YHL018W	1	69705	70067	ON	8	YHL018W	(69705..70067)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YHL017W	1	70273	71871	ON	8	YHL017W	(70273..71871)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
YHL016C	0	72034	74241	ON	8	DUR3	complement(72034..74241)	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YHL015W-A	1	74696	74779	OFF	8	YHL015W-A	(74696..74779)	Putative protein of unknown function
YHL015W	1	75409	75774	ON	8	RPS20	(75409..75774)	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YHL014C	0	76094	77311	ON	8	YLF2	complement(76094..77311)	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL013C	0	77427	78350	ON	8	OTU2	complement(77427..78350)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YHL012W	1	78932	80413	ON	8	YHL012W	(78932..80413)	Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
YHL011C	0	80650	81612	ON	8	PRS3	complement(80650..81612)	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YHL010C	0	81960	83717	ON	8	YHL010C	complement(81960..83717)	Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
YHL009C	0	84064	85056	ON	8	YAP3	complement(84064..85056)	Basic leucine zipper (bZIP) transcription factor
YHL008C	0	92623	94506	ON	8	YHL008C	complement(92623..94506)	Putative protein of unknown function, does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YHL007C	0	95114	97933	ON	8	STE20	complement(95114..97933)	Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
YHL006W-A	1	97728	98081	OFF	8	YHL006W-A	(97728..98081)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL006C	0	98339	98791	ON	8	SHU1	complement(98339..98791)	Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YHL005C	0	98824	99216	OFF	8	YHL005C	complement(98824..99216)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W
YHL004W	1	99215	100399	ON	8	MRP4	(99215..100399)	Mitochondrial ribosomal protein of the small subunit
YHL003C	0	100644	101879	ON	8	LAG1	complement(100644..101879)	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YHL002C-A	0	102582	103070	OFF	8	YHL002C-A	complement(102582..103070)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHL002W	1	102607	103965	ON	8	HSE1	(102607..103965)	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YHL001W	1	104272	105086	ON	8	RPL14B	(104272..104400,104799..105086)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YHR001W	1	106050	107363	ON	8	OSH7	(106050..107363)	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YHR001W-A	1	107821	108117	ON	8	QCR10	(107821..107826,107890..108117)	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
YHR002W	1	108807	109880	ON	8	LEU5	(108807..109880)	Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
YHR003C	0	110023	111312	ON	8	YHR003C	complement(110023..111312)	Protein of unknown function, localized to the mitochondrial outer membrane
YHR004C	0	111749	113089	ON	8	NEM1	complement(111749..113089)	Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YHR005C	0	113494	114912	ON	8	GPA1	complement(113494..114912)	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YHR005C-A	0	115615	115896	ON	8	MRS11	complement(115615..115896)	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YHR006W	1	117809	119434	ON	8	STP2	(117809..119434)	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YHR007C	0	120086	121678	ON	8	ERG11	complement(120086..121678)	Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YHR007C-A	0	122545	122760	OFF	8	YHR007C-A	complement(122545..122760)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHR008C	0	122884	123585	ON	8	SOD2	complement(122884..123585)	Mitochondrial superoxide dismutase; protects cells against oxygen toxicity
YHR009C	0	124104	125675	ON	8	YHR009C	complement(124104..125675)	Putative protein of unknown function; not an essential gene
YHR010W	1	126515	127486	ON	8	RPL27A	(126515..126545,127107..127486)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YHR011W	1	127774	129114	ON	8	DIA4	(127774..129114)	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
YHR012W	1	129475	130442	ON	8	VPS29	(129475..129522,129642..130442)	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
YHR013C	0	130724	131440	ON	8	ARD1	complement(130724..131440)	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YHR014W	1	132040	132915	ON	8	SPO13	(132040..132915)	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YHR015W	1	134547	136526	ON	8	MIP6	(134547..136526)	Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YHR016C	0	136874	138448	ON	8	YSC84	complement(136874..138233,138402..138448)	Protein involved in the organization of the actin cytoskeleton; contains SH3 domain similar to Rvs167p
YHR017W	1	138687	139844	ON	8	YSC83	(138687..139844)	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YHR018C	0	140004	141395	ON	8	ARG4	complement(140004..141395)	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YHR019C	0	141887	143551	ON	8	DED81	complement(141887..143551)	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YHR020W	1	143989	146055	ON	8	YHR020W	(143989..146055)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YHR021C	0	147864	148662	ON	8	RPS27B	complement(147864..148109,148660..148662)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YHR021W-A	1	149218	149673	OFF	8	ECM12	(149218..149673)	Non-essential protein of unknown function
YHR022C	0	149568	150338	ON	8	YHR022C	complement(149568..150338)	Putative protein of unknown function; YHR022C is not an essential gene.
YHR022C-A	0	151210	151299	OFF	8	YHR022C-A	complement(151210..151299)	Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR023W	1	151659	157445	ON	8	MYO1	(151659..157445)	Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YHR024C	0	157737	159185	ON	8	MAS2	complement(157737..159185)	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YHR025W	1	159431	160504	ON	8	THR1	(159431..160504)	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YHR026W	1	160837	161478	ON	8	PPA1	(160837..161478)	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YHR027C	0	161723	164704	ON	8	RPN1	complement(161723..164704)	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
YHR028C	0	164971	167427	ON	8	DAP2	complement(164971..167427)	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
YHR028W-A	1	167345	167665	OFF	8	YHR028W-A	(167345..167665)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR029C	0	167670	168554	ON	8	YHI9	complement(167670..168554)	Protein of unknown function that is a member of the PhzF superfamily, although unlike its bacterial homolog, is most likely not involved in phenazine production; possibly involved in a membrane regulation metabolic pathway
YHR030C	0	168883	170337	ON	8	SLT2	complement(168883..170337)	Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YHR031C	0	170792	172963	ON	8	RRM3	complement(170792..172963)	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YHR032W	1	173337	175082	ON	8	YHR032W	(173337..175082)	Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA)
YHR032W-A	1	175188	175367	OFF	8	YHR032W-A	(175188..175367)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YHR032C-A	0	175268	175387	OFF	8	YHR032C-A	complement(175268..175387)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A
YHR033W	1	175541	176812	ON	8	YHR033W	(175541..176812)	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YHR034C	0	176958	177992	ON	8	PIH1	complement(176958..177992)	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
YHR035W	1	178212	180104	ON	8	YHR035W	(178212..180104)	Putative protein of unknown function; not an essential gene
YHR036W	1	180338	181753	ON	8	BRL1	(180338..181753)	Essential nuclear envelope integral membrane protein identified as a suppressor of a cold-sensitive mutant of CRM1, a karyopherin; homologous to and interacts with Brr6p, which is a nuclear envelope protein involved in nuclear export
YHR037W	1	181970	183697	ON	8	PUT2	(181970..183697)	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YHR038W	1	184059	184751	ON	8	RRF1	(184059..184751)	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YHR039C	0	184868	186802	ON	8	MSC7	complement(184868..186802)	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YHR039C-A	0	187166	187672	ON	8	VMA10	complement(187166..187507,187670..187672)	Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification
YHR040W	1	187917	189017	ON	8	BCD1	(187917..189017)	Essential protein required for the accumulation of box C/D snoRNA
YHR041C	0	189124	189857	ON	8	SRB2	complement(189124..189742,189844..189857)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YHR042W	1	190536	192611	ON	8	NCP1	(190536..192611)	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YHR043C	0	192798	193538	ON	8	DOG2	complement(192798..193538)	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YHR044C	0	194061	194801	ON	8	DOG1	complement(194061..194801)	2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
YHR045W	1	195544	197226	ON	8	YHR045W	(195544..197226)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YHR046C	0	197391	198278	ON	8	INM1	complement(197391..198278)	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YHR047C	0	198733	201303	ON	8	AAP1	complement(198733..201303)	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YHR048W	1	204600	206144	ON	8	YHR048W	(204600..206144)	Putative protein of unknown function, has similarity to multidrug resistance proteins; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YHR049W	1	206455	207186	ON	8	FSH1	(206455..207186)	Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YHR049C-A	0	207213	207524	OFF	8	YHR049C-A	complement(207213..207524)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR050W	1	207648	209297	ON	8	SMF2	(207648..209297)	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YHR050W-A	1	209469	209639	OFF	8	YHR050W-A	(209469..209639)	Protein of unknown function; identified by expression profiling and mass spectrometry
YHR051W	1	209699	210145	ON	8	COX6	(209699..210145)	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
YHR052W	1	210842	211972	ON	8	CIC1	(210842..211972)	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YHR052W-A	1	212512	212706	OFF	8	YHR052W-A	(212512..212706)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1
YHR053C	0	212537	212722	ON	8	CUP1-1	complement(212537..212722)	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YHR054C	0	213187	214251	OFF	8	YHR054C	complement(213187..214251)	Putative protein of unknown function
YHR054W-A	1	214510	214704	OFF	8	YHR054W-A	(214510..214704)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YHR055C	0	214535	214720	ON	8	CUP1-2	complement(214535..214720)	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YHR056C	0	215185	217836	ON	8	RSC30	complement(215185..217836)	Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive
YHR056W-A	1	217408	217842	OFF	8	YHR056W-A	(217408..217842)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR057C	0	218228	218845	ON	8	CPR2	complement(218228..218845)	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
YHR058C	0	218999	219886	ON	8	MED6	complement(218999..219886)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YHR059W	1	220110	220502	ON	8	FYV4	(220110..220502)	Protein of unknown function, required for survival upon exposure to K1 killer toxin
YHR060W	1	220727	221272	ON	8	VMA22	(220727..221272)	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YHR061C	0	221536	222480	ON	8	GIC1	complement(221536..222480)	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
YHR062C	0	222879	223760	ON	8	RPP1	complement(222879..223760)	Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YHR063C	0	224032	225171	ON	8	PAN5	complement(224032..225171)	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YHR063W-A	1	225444	225779	OFF	8	YHR063W-A	(225444..225779)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR064C	0	225527	227143	ON	8	SSZ1	complement(225527..227143)	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YHR065C	0	227534	229039	ON	8	RRP3	complement(227534..229039)	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YHR066W	1	229337	230698	ON	8	SSF1	(229337..230698)	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YHR067W	1	230972	231814	ON	8	HTD2	(230972..231814)	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YHR068W	1	232135	233298	ON	8	DYS1	(232135..233298)	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YHR069C	0	233581	234660	ON	8	RRP4	complement(233581..234660)	3'-5' exoribonuclease involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p
YHR069C-A	0	234876	235238	OFF	8	YHR069C-A	complement(234876..235238)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR070W	1	234883	236382	ON	8	TRM5	(234883..236382)	tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
YHR070C-A	0	236104	236514	OFF	8	YHR070C-A	complement(236104..236514)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YHR071W	1	237006	237695	ON	8	PCL5	(237006..237695)	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YHR071C-A	0	238912	239232	OFF	8	YHR071C-A	complement(238912..239232)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YHR072W	1	239100	241295	ON	8	ERG7	(239100..241295)	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YHR072W-A	1	241666	241842	ON	8	NOP10	(241666..241842)	Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
YHR073W	1	242584	245574	ON	8	OSH3	(242584..245574)	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YHR073W-A	1	242870	243046	OFF	8	YHR073W-A	(242870..243046)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry
YHR073C-B	0	245424	245504	OFF	8	YHR073C-B	complement(245424..245504)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry
YHR074W	1	246195	248339	ON	8	QNS1	(246195..248339)	Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YHR075C	0	248441	249643	ON	8	PPE1	complement(248441..249643)	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YHR076W	1	251103	252227	ON	8	PTC7	(251103..251157,251251..252227)	Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YHR077C	0	252376	255758	ON	8	NMD2	complement(252376..255639,255753..255758)	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
YHR078W	1	256362	258020	ON	8	YHR078W	(256362..258020)	High osmolarity-regulated gene of unknown function
YHR079C	0	258246	261593	ON	8	IRE1	complement(258246..261593)	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
YHR079C-A	0	262194	262555	ON	8	SAE3	complement(262194..262356,262443..262555)	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
YHR080C	0	262803	266840	ON	8	YHR080C	complement(262803..266840)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR081W	1	267540	268094	ON	8	LRP1	(267540..268094)	Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YHR082C	0	268461	271550	ON	8	KSP1	complement(268461..271550)	Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YHR083W	1	272629	273618	ON	8	SAM35	(272629..273618)	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YHR084W	1	274176	276242	ON	8	STE12	(274176..276242)	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
YHR085W	1	276766	277770	ON	8	IPI1	(276766..277770)	Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YHR086W	1	278155	279726	ON	8	NAM8	(278155..279726)	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YHR086W-A	1	280233	280394	OFF	8	YHR086W-A	(280233..280394)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YHR087W	1	280822	281157	ON	8	YHR087W	(280822..281157)	Protein of unknown function involved in RNA metabolism; this single domain protein has structural similarity to the N-terminal domain of SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1/YLR022C)
YHR088W	1	281497	282384	ON	8	RPF1	(281497..282384)	Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YHR089C	0	282683	283300	ON	8	GAR1	complement(282683..283300)	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YHR090C	0	283779	284627	ON	8	YNG2	complement(283779..284627)	Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
YHR091C	0	284841	286772	ON	8	MSR1	complement(284841..286772)	Mitochondrial arginyl-tRNA synthetase
YHR092C	0	287132	288814	ON	8	HXT4	complement(287132..288814)	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YHR093W	1	289145	289693	OFF	8	AHT1	(289145..289693)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YHR094C	0	290916	292628	ON	8	HXT1	complement(290916..292628)	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YHR095W	1	292946	293380	OFF	8	YHR095W	(292946..293380)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR096C	0	294672	296450	ON	8	HXT5	complement(294672..296450)	Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YHR097C	0	297388	298612	ON	8	YHR097C	complement(297388..298363,298488..298612)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YHR098C	0	299148	301937	ON	8	SFB3	complement(299148..301937)	Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate
YHR099W	1	302764	313998	ON	8	TRA1	(302764..313998)	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
YHR100C	0	314119	314676	ON	8	YHR100C	complement(314119..314676)	Putative protein of unknown function, required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR101C	0	314877	315971	ON	8	BIG1	complement(314877..315774,315862..315971)	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
YHR102W	1	316575	319817	ON	8	KIC1	(316575..319817)	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
YHR103W	1	320417	322975	ON	8	SBE22	(320417..322975)	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YHR104W	1	323412	324395	ON	8	GRE3	(323412..324395)	Aldose reductase involved in methylglyoxal, d-xylose and arabinose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
YHR105W	1	324769	325413	ON	8	YPT35	(324769..325413)	Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
YHR106W	1	325601	326629	ON	8	TRR2	(325601..326629)	Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p, contains active-site motif (CAVC) present in prokaryotic thioredoxin reductases, binds NADPH and FAD
YHR107C	0	326816	328039	ON	8	CDC12	complement(326816..328039)	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YHR108W	1	328306	330063	ON	8	GGA2	(328306..330063)	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YHR109W	1	330313	332070	ON	8	CTM1	(330313..332070)	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
YHR110W	1	332285	332923	ON	8	ERP5	(332285..332923)	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YHR111W	1	333075	334397	ON	8	UBA4	(333075..334397)	Protein that activates Urm1p before its conjugation to proteins (urmylation); one target is the thioredoxin peroxidase Ahp1p, suggesting a role of urmylation in the oxidative stress response
YHR112C	0	334530	335666	ON	8	YHR112C	complement(334530..335666)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR113W	1	336340	337812	ON	8	YHR113W	(336340..337812)	Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes
YHR114W	1	338086	339987	ON	8	BZZ1	(338086..339987)	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
YHR115C	0	340112	341362	ON	8	DMA1	complement(340112..341362)	Protein involved in regulating spindle position and orientation, functionally redundant with Dma2p; homolog of S. pombe Dma1 and H. sapiens Chfr
YHR116W	1	341668	342123	ON	8	COX23	(341668..342123)	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p
YHR117W	1	342352	344271	ON	8	TOM71	(342352..344271)	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
YHR118C	0	344324	345631	ON	8	ORC6	complement(344324..345631)	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p
YHR119W	1	346046	349288	ON	8	SET1	(346046..349288)	Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain
YHR120W	1	349577	352456	ON	8	MSH1	(349577..352456)	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YHR121W	1	352759	353322	ON	8	LSM12	(352759..353322)	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
YHR122W	1	353628	354323	ON	8	YHR122W	(353628..354323)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene
YHR123W	1	354818	356084	ON	8	EPT1	(354818..354867,354959..356084)	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YHR124W	1	356564	358447	ON	8	NDT80	(356564..358447)	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YHR125W	1	358861	359166	OFF	8	YHR125W	(358861..359166)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR126C	0	359705	360184	ON	8	YHR126C	complement(359705..360184)	Putative protein of unknown function; transcription dependent upon Azf1p
YHR127W	1	360916	361647	ON	8	YHR127W	(360916..361647)	Protein of unknown function; localizes to the nucleus
YHR128W	1	362118	362768	ON	8	FUR1	(362118..362768)	Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YHR129C	0	363002	364156	ON	8	ARP1	complement(363002..364156)	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
YHR130C	0	364968	365303	OFF	8	YHR130C	complement(364968..365303)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR131C	0	365343	367895	ON	8	YHR131C	complement(365343..367895)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YHR131W-A	1	367750	367995	OFF	8	YHR131W-A	(367750..367995)	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YHR131C
YHR132C	0	368505	369797	ON	8	ECM14	complement(368505..369797)	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
YHR132W-A	1	370057	370452	ON	8	YHR132W-A	(370057..370452)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR133C	0	370725	371600	ON	8	NSG1	complement(370725..371600)	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YHR134W	1	371752	372561	ON	8	WSS1	(371752..372561)	Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks
YHR135C	0	372697	374313	ON	8	YCK1	complement(372697..374313)	Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
YHR136C	0	374657	375103	ON	8	SPL2	complement(374657..375103)	Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YHR137W	1	375712	377253	ON	8	ARO9	(375712..377253)	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YHR137C-A	0	375741	376391	OFF	8	YHR137C-A	complement(375741..376391)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching
YHR138C	0	377358	377702	ON	8	YHR138C	complement(377358..377702)	Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YHR139C	0	378222	379202	ON	8	SPS100	complement(378222..379202)	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YHR139C-A	0	380111	380422	OFF	8	YHR139C-A	complement(380111..380422)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR140W	1	380575	381294	ON	8	YHR140W	(380575..381294)	Putative integral membrane protein of unknown function
YHR141C	0	381993	382754	ON	8	RPL42B	complement(381993..382309,382751..382754)	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YHR142W	1	383541	384491	ON	8	CHS7	(383541..384491)	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YHR143W	1	385513	386490	ON	8	DSE2	(385513..386490)	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YHR143W-A	1	387236	387448	ON	8	RPC10	(387236..387448)	RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YHR144C	0	387791	388729	ON	8	DCD1	complement(387791..388729)	Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YHR145C	0	388984	389340	OFF	8	YHR145C	complement(388984..389340)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR146W	1	390303	391700	ON	8	CRP1	(390303..391700)	Protein that binds to cruciform DNA structures
YHR147C	0	392642	393286	ON	8	MRPL6	complement(392642..393286)	Mitochondrial ribosomal protein of the large subunit
YHR148W	1	393537	394088	ON	8	IMP3	(393537..394088)	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YHR149C	0	394458	396662	ON	8	SKG6	complement(394458..396662)	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YHR150W	1	397254	398993	ON	8	PEX28	(397254..398993)	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YHR151C	0	399271	400851	ON	8	YHR151C	complement(399271..400851)	Putative protein of unknown function
YHR152W	1	401437	401958	ON	8	SPO12	(401437..401958)	Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis
YHR153C	0	402089	402685	ON	8	SPO16	complement(402089..402685)	Protein of unknown function, required for spore formation
YHR154W	1	402969	406181	ON	8	RTT107	(402969..406181)	Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YHR155W	1	407106	410792	ON	8	YSP1	(407106..410792)	Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
YHR156C	0	411387	412409	ON	8	LIN1	complement(411387..412409)	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
YHR157W	1	412910	413458	ON	8	REC104	(412910..413458)	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
YHR158C	0	413688	417182	ON	8	KEL1	complement(413688..417182)	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YHR159W	1	417552	419066	ON	8	YHR159W	(417552..419066)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate
YHR160C	0	419224	420075	ON	8	PEX18	complement(419224..420075)	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
YHR161C	0	420376	422289	ON	8	YAP1801	complement(420376..422289)	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
YHR162W	1	423075	423464	ON	8	YHR162W	(423075..423464)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YHR163W	1	423726	424475	ON	8	SOL3	(423726..424475)	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YHR164C	0	424612	429180	ON	8	DNA2	complement(424612..429180)	Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
YHR165C	0	429709	436950	ON	8	PRP8	complement(429709..436950)	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing
YHR165W-A	1	436649	436960	OFF	8	YHR165W-A	(436649..436960)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR166C	0	437172	439052	ON	8	CDC23	complement(437172..439052)	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YHR167W	1	439344	440129	ON	8	THP2	(439344..440129)	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
YHR168W	1	440379	441878	ON	8	MTG2	(440379..441878)	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
YHR169W	1	442182	443477	ON	8	DBP8	(442182..443477)	Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
YHR170W	1	443829	445385	ON	8	NMD3	(443829..445385)	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YHR171W	1	445713	447605	ON	8	ATG7	(445713..447605)	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
YHR172W	1	448335	450806	ON	8	SPC97	(448335..450806)	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YHR173C	0	450815	451153	OFF	8	YHR173C	complement(450815..451153)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR174W	1	451327	452640	ON	8	ENO2	(451327..452640)	Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YHR175W	1	452872	453441	ON	8	CTR2	(452872..453441)	Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation
YHR175W-A	1	453558	453707	OFF	8	YHR175W-A	(453558..453707)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YHR176W	1	454229	455527	ON	8	FMO1	(454229..455527)	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YHR177W	1	456591	457952	ON	8	YHR177W	(456591..457952)	Putative protein of unknown function
YHR178W	1	459299	461530	ON	8	STB5	(459299..461530)	Activator of multidrug resistance genes, forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a PDRE (pleotropic drug resistance element) in vitro; binds Sin3p in a two-hybrid assay
YHR179W	1	462502	463704	ON	8	OYE2	(462502..463704)	Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YHR180W	1	465178	465669	OFF	8	YHR180W	(465178..465669)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR180W-A	1	466932	467114	OFF	8	YHR180W-A	(466932..467114)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YHR180C-B	0	466958	467062	OFF	8	YHR180C-B	complement(466958..467062)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A
YHR181W	1	467228	467914	ON	8	SVP26	(467228..467914)	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR182W	1	468219	470576	ON	8	YHR182W	(468219..470576)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm
YHR182C-A	0	470939	471412	OFF	8	YHR182C-A	complement(470939..471412)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR183W	1	470960	472429	ON	8	GND1	(470960..472429)	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YHR184W	1	472744	474459	ON	8	SSP1	(472744..474459)	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
YHR185C	0	474627	475340	ON	8	PFS1	complement(474627..475340)	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies of a cell during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
YHR186C	0	475999	480672	ON	8	KOG1	complement(475999..480672)	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
YHR187W	1	480990	481919	ON	8	IKI1	(480990..481919)	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
YHR188C	0	482005	483837	ON	8	GPI16	complement(482005..483837)	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
YHR189W	1	484028	484600	ON	8	PTH1	(484028..484600)	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YHR190W	1	484845	486179	ON	8	ERG9	(484845..486179)	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
YHR191C	0	486230	486631	ON	8	CTF8	complement(486230..486631)	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
YHR192W	1	486826	487662	ON	8	YHR192W	(486826..487662)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
YHR193C	0	487712	488236	ON	8	EGD2	complement(487712..488236)	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
YHR193C-A	0	488653	489027	OFF	8	YHR193C-A	complement(488653..489027)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31
YHR194W	1	488657	490396	ON	8	MDM31	(488657..490396)	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YHR195W	1	490747	491712	ON	8	NVJ1	(490747..491712)	Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YHR196W	1	491931	493658	ON	8	UTP9	(491931..493658)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YHR197W	1	493896	496187	ON	8	RIX1	(493896..496187)	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YHR198C	0	496315	497280	ON	8	YHR198C	complement(496315..497280)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR199C	0	497490	498422	ON	8	YHR199C	complement(497490..498422)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR199C-A	0	498571	498859	ON	8	YHR199C-A	complement(498571..498719,498787..498859)	Putative protein of unknown function; transcribed sequence appears to contain an intron
YHR200W	1	499079	499885	ON	8	RPN10	(499079..499885)	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
YHR201C	0	499950	501143	ON	8	PPX1	complement(499950..501143)	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YHR202W	1	502388	504196	ON	8	YHR202W	(502388..504196)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YHR203C	0	504476	505530	ON	8	RPS4B	complement(504476..505247,505517..505530)	Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YHR204W	1	506319	508709	ON	8	MNL1	(506319..508709)	Alpha mannosidase-like protein of the endoplasmic reticulum required for degradation of glycoproteins but not for processing of N-linked oligosaccharides
YHR205W	1	509363	511837	ON	8	SCH9	(509363..511837)	Protein kinase that regulates signal transduction activity and G1 progression, controls cAPK activity, required for nitrogen activation of the FGM pathway, involved in life span regulation, homologous to mammalian Akt/PKB
YHR206W	1	512732	514600	ON	8	SKN7	(512732..514600)	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YHR207C	0	514905	516485	ON	8	SET5	complement(514905..516485)	Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
YHR208W	1	517532	518713	ON	8	BAT1	(517532..518713)	Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YHR209W	1	519437	520312	ON	8	YHR209W	(519437..520312)	Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance
YHR210C	0	520712	521737	ON	8	YHR210C	complement(520712..521737)	Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YHR211W	1	525392	528619	ON	8	FLO5	(525392..528619)	Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YHR212C	0	537759	538094	OFF	8	YHR212C	complement(537759..538094)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR212W-A	1	538742	538945	OFF	8	YHR212W-A	(538742..538945)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR213W	1	539151	539747	ON	8	YHR213W	(539151..539747)	Putative protein of unknown function
YHR213W-A	1	540549	540782	OFF	8	YHR213W-A	(540549..540782)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR213W-B	1	540800	541099	OFF	8	YHR213W-B	(540800..541099)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR214W	1	541651	542262	ON	8	YHR214W	(541651..542262)	Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein
YHR214W-A	1	543008	543493	OFF	8	YHR214W-A	(543008..543493)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; similar to the fungal specific protein encoded by YAR068W; induced by zinc deficiency
YHR214C-D	0	550648	550941	OFF	8	YHR214C-D	complement(550648..550941)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR214C-E	0	551200	551499	OFF	8	YHR214C-E	complement(551200..551499)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR215W	1	552099	553502	ON	8	PHO12	(552099..553502)	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation
YHR216W	1	554396	555967	ON	8	IMD2	(554396..555967)	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YHR217C	0	556581	557042	OFF	8	YHR217C	complement(556581..557042)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YHR218W	1	558014	559924	ON	8	YHR218W	(558014..558615,558715..559924)	Helicase-like protein encoded within the telomeric Y' element
YHR218W-A	1	559932	560249	OFF	8	YHR218W-A	(559932..560249)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR219W	1	560173	562047	ON	8	YHR219W	(560173..562047)	Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII
YHR219C-A	0	561199	561681	OFF	8	YHR219C-A	complement(561199..561681)	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YIL177C	0	483	6147	ON	9	YIL177C	complement(483..4598,4987..6147)	Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors
YIL177W-A	1	846	1328	OFF	9	YIL177W-A	(846..1328)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C
YIL176C	0	8793	9155	ON	9	YIL176C	complement(8793..9155)	Hypothetical protein
YIL175W	1	9183	9500	OFF	9	YIL175W	(9183..9500)	Hypothetical protein
YIL174W	1	9469	9696	OFF	9	YIL174W	(9469..9696)	Hypothetical protein
YIL173W	1	11492	16141	ON	9	VTH1	(11492..16141)	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YIL172C	0	16784	18553	ON	9	YIL172C	complement(16784..18553)	Putative protein of unknown function with similarity to glucosidases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YIL171W-A	1	18260	18712	OFF	9	YIL171W-A	(18260..18712)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL171W	1	19515	19844	ON	9	YIL171W	(19515..19844)	Possible pseudogene in strain S288C; YIL171W and the adjacent ORF, YIL170W/HXT12, together encode a non-functional member of the hexose transporter family
YIL170W	1	19847	21220	ON	9	HXT12	(19847..21220)	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
YIL169C	0	23119	26106	ON	9	YIL169C	complement(23119..26106)	Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YIL168W	1	29032	29415	ON	9	YIL168W	(29032..29415)	Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase
YIL167W	1	29416	30048	ON	9	SDL1	(29416..30048)	Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase
YIL166C	0	30938	32566	ON	9	YIL166C	complement(30938..32566)	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YIL165C	0	33718	34077	ON	9	YIL165C	complement(33718..34077)	Putative protein of unknown function; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene
YIL164C	0	34087	34686	ON	9	NIT1	complement(34087..34686)	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YIL163C	0	36899	37252	OFF	9	YIL163C	complement(36899..37252)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL162W	1	37385	38983	ON	9	SUC2	(37385..38983)	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YIL161W	1	39433	40140	ON	9	YIL161W	(39433..40140)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
YIL160C	0	40191	41444	ON	9	POT1	complement(40191..41444)	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YIL159W	1	41825	45952	ON	9	BNR1	(41825..45952)	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YIL158W	1	46201	46815	ON	9	YIL158W	(46201..46815)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YIL157C	0	46949	47542	ON	9	YIL157C	complement(46949..47542)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant is defective in cytochrome oxidase and is respiratory deficient
YIL156W-A	1	47292	47693	OFF	9	YIL156W-A	(47292..47693)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL156W-B	1	47690	47973	ON	9	YIL156W-B	(47690..47698,47761..47973)	Putative protein of unknown function, originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts
YIL156W	1	48091	51306	ON	9	UBP7	(48091..51306)	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YIL155C	0	51759	53708	ON	9	GUT2	complement(51759..53708)	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YIL154C	0	53981	55021	ON	9	IMP2'	complement(53981..55021)	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
YIL153W	1	55198	56379	ON	9	RRD1	(55198..56379)	Activator of the phosphotyrosyl phosphatase activity of PP2A, peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; subunit of the Tap42p-Sit4p-Rrd1p complex
YIL152W	1	56545	57252	ON	9	YIL152W	(56545..57252)	Putative protein of unknown function
YIL151C	0	57338	60694	ON	9	YIL151C	complement(57338..60694)	Putative protein of unknown function, predicted to contain a PINc (PilT N terminus) domain
YIL150C	0	61013	62728	ON	9	MCM10	complement(61013..62728)	Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
YIL149C	0	63028	68067	ON	9	MLP2	complement(63028..68067)	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YIL148W	1	68708	69528	ON	9	RPL40A	(68708..68715,69150..69528)	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YIL147C	0	69791	73453	ON	9	SLN1	complement(69791..73453)	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
YIL146C	0	74184	75773	ON	9	ECM37	complement(74184..75773)	Non-essential protein of unknown function
YIL145C	0	76354	77283	ON	9	PAN6	complement(76354..77283)	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YIL144W	1	78074	80149	ON	9	TID3	(78074..80149)	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
YIL143C	0	80510	83041	ON	9	SSL2	complement(80510..83041)	Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3
YIL142C-A	0	83208	83540	OFF	9	YIL142C-A	complement(83208..83540)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL142W	1	83302	84885	ON	9	CCT2	(83302..84885)	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YIL141W	1	85053	85442	OFF	9	YIL141W	(85053..85442)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL140W	1	85366	87837	ON	9	AXL2	(85366..87837)	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
YIL139C	0	87979	88716	ON	9	REV7	complement(87979..88716)	Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
YIL138C	0	89230	89715	ON	9	TPM2	complement(89230..89715)	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
YIL137C	0	89948	92788	ON	9	TMA108	complement(89948..92788)	Protein that associates with ribosomes; putative metalloprotease
YIL136W	1	93619	94800	ON	9	OM45	(93619..94800)	Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YIL135C	0	95065	96375	ON	9	VHS2	complement(95065..96375)	Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
YIL134C-A	0	96522	96725	OFF	9	YIL134C-A	complement(96522..96725)	Putative protein of unknown function, identified by fungal homology and RT-PCR
YIL134W	1	97395	98330	ON	9	FLX1	(97395..98330)	Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane
YIL133C	0	98527	99416	ON	9	RPL16A	complement(98527..99095,99386..99416)	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YIL132C	0	99860	100501	ON	9	CSM2	complement(99860..100501)	Protein required for accurate chromosome segregation during meiosis
YIL131C	0	100781	102235	ON	9	FKH1	complement(100781..102235)	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YIL130W	1	102782	105676	ON	9	ASG1	(102782..105676)	Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins
YIL129C	0	106107	113237	ON	9	TAO3	complement(106107..113237)	Protein involved in cell morphogenesis and proliferation, associated with protein kinase Cbk1p; mutants activate OCH1 transcription
YIL128W	1	113806	116904	ON	9	MET18	(113806..116904)	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
YIL127C	0	117024	117644	ON	9	YIL127C	complement(117024..117644)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YIL126W	1	117992	122071	ON	9	STH1	(117992..122071)	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YIL125W	1	122689	125733	ON	9	KGD1	(122689..125733)	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YIL124W	1	126204	127097	ON	9	AYR1	(126204..127097)	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
YIL123W	1	128151	129578	ON	9	SIM1	(128151..129578)	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YIL122W	1	130607	131662	ON	9	POG1	(130607..131662)	Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YIL121W	1	132241	133869	ON	9	QDR2	(132241..133869)	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YIL120W	1	134414	136105	ON	9	QDR1	(134414..136105)	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barba
YIL119C	0	136651	137874	ON	9	RPI1	complement(136651..137874)	Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YIL118W	1	139749	140444	ON	9	RHO3	(139749..140444)	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YIL117C	0	140610	141566	ON	9	PRM5	complement(140610..141566)	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YIL116W	1	142925	144082	ON	9	HIS5	(142925..144082)	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YIL115W-A	1	144265	144636	OFF	9	YIL115W-A	(144265..144636)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C
YIL115C	0	144324	148706	ON	9	NUP159	complement(144324..148706)	Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export
YIL114C	0	149140	149985	ON	9	POR2	complement(149140..149985)	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
YIL113W	1	150556	151185	ON	9	SDP1	(150556..151185)	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YIL112W	1	151592	154843	ON	9	HOS4	(151592..154843)	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
YIL111W	1	155219	155762	ON	9	COX5B	(155219..155219,155308..155762)	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YIL110W	1	156042	157175	ON	9	YIL110W	(156042..157175)	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants
YIL109C	0	157382	160162	ON	9	SEC24	complement(157382..160162)	Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p
YIL108W	1	160884	162974	ON	9	YIL108W	(160884..162974)	Putative metalloprotease
YIL107C	0	163275	165758	ON	9	PFK26	complement(163275..165758)	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YIL106W	1	166412	167441	ON	9	MOB1	(166412..166431,166517..167441)	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
YIL105C	0	167578	169638	ON	9	SLM1	complement(167578..169638)	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; subunit of and phosphorylated by the TORC2 complex
YIL105W-A	1	167661	167801	OFF	9	YIL105W-A	(167661..167801)	Dubious open reading frame; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YIL104C	0	169979	171502	ON	9	SHQ1	complement(169979..171502)	Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p
YIL103W	1	171748	173025	ON	9	DPH1	(171748..173025)	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
YIL102C-A	0	173362	173589	ON	9	YIL102C-A	complement(173362..173589)	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YIL102C	0	174579	174884	ON	9	YIL102C	complement(174579..174884)	Putative protein of unknown function
YIL101C	0	175304	177247	ON	9	XBP1	complement(175304..177247)	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YIL100C-A	0	177340	177678	OFF	9	YIL100C-A	complement(177340..177678)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL100W	1	177370	177723	OFF	9	YIL100W	(177370..177723)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YIL099W	1	178001	179650	ON	9	SGA1	(178001..179650)	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YIL098C	0	179769	180236	ON	9	FMC1	complement(179769..180236)	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
YIL097W	1	180424	181974	ON	9	FYV10	(180424..181974)	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain
YIL096C	0	182114	183124	ON	9	YIL096C	complement(182114..183124)	Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YIL095W	1	183934	186366	ON	9	PRK1	(183934..186366)	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YIL094C	0	186514	187629	ON	9	LYS12	complement(186514..187629)	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YIL093C	0	187987	188781	ON	9	RSM25	complement(187987..188781)	Mitochondrial ribosomal protein of the small subunit
YIL092W	1	189063	190964	ON	9	YIL092W	(189063..190964)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YIL091C	0	191027	193192	ON	9	YIL091C	complement(191027..193192)	Protein required for cell viability
YIL090W	1	193592	195067	ON	9	ICE2	(193592..195067)	Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
YIL089W	1	195596	196213	ON	9	YIL089W	(195596..196213)	Putative protein of unknown function
YIL088C	0	197928	199400	ON	9	AVT7	complement(197928..199400)	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YIL087C	0	199643	200116	ON	9	YIL087C	complement(199643..200116)	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL086C	0	200150	200458	OFF	9	YIL086C	complement(200150..200458)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL085C	0	200487	202040	ON	9	KTR7	complement(200487..202040)	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YIL084C	0	202273	203256	ON	9	SDS3	complement(202273..203256)	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
YIL083C	0	203553	204650	ON	9	YIL083C	complement(203553..204650)	Putative phosphopantothenoylcysteine synthetase (PPCS) that catalyzes the second step in the biosynthesis of coenzyme A from pantothenate; conserved in bacteria, humans, and plants; essential for viability
YIL080W	1	205632	210354	OFF	9	YIL080W	(205632..206481,206483..210354)	TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition
YIL082W	1	205632	206504	OFF	9	YIL082W	(205632..206504)	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag
YIL079C	0	210920	212002	ON	9	AIR1	complement(210920..212002)	RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p
YIL078W	1	212496	214700	ON	9	THS1	(212496..214700)	Threonyl-tRNA synthetase, essential cytoplasmic protein
YIL077C	0	214988	215950	ON	9	YIL077C	complement(214988..215950)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YIL076W	1	216655	217545	ON	9	SEC28	(216655..217545)	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YIL075C	0	217860	220697	ON	9	RPN2	complement(217860..220697)	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
YIL074C	0	221078	222487	ON	9	SER33	complement(221078..222487)	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YIL073C	0	222934	225951	ON	9	SPO22	complement(222934..225806,225897..225951)	Meiosis-specific protein essential for chromosome synapsis, similar to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosis
YIL072W	1	226599	228416	ON	9	HOP1	(226599..228416)	Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
YIL071W-A	1	228547	229023	OFF	9	YIL071W-A	(228547..229023)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL071C	0	228657	229991	ON	9	PCI8	complement(228657..229991)	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YIL070C	0	230269	231069	ON	9	MAM33	complement(230269..231069)	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
YIL069C	0	231550	232366	ON	9	RPS24B	complement(231550..231954,232364..232366)	Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YIL068W-A	1	233010	233393	OFF	9	YIL068W-A	(233010..233393)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL068C	0	233054	235471	ON	9	SEC6	complement(233054..235471)	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly
YIL067C	0	235721	237757	ON	9	YIL067C	complement(235721..237757)	Uncharacterized protein of unknown function
YIL066W-A	1	237363	237806	OFF	9	YIL066W-A	(237363..237806)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL066C	0	238096	240705	ON	9	RNR3	complement(238096..240705)	Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YIL065C	0	241305	241772	ON	9	FIS1	complement(241305..241772)	Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
YIL064W	1	241940	242713	ON	9	YIL064W	(241940..242713)	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
YIL063C	0	242758	243741	ON	9	YRB2	complement(242758..243741)	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
YIL062C	0	243995	244459	ON	9	ARC15	complement(243995..244459)	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YIL061C	0	244654	245556	ON	9	SNP1	complement(244654..245556)	Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
YIL060W	1	246389	246823	OFF	9	YIL060W	(246389..246823)	Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YIL059C	0	246547	246912	OFF	9	YIL059C	complement(246547..246912)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YIL058W	1	246911	247195	OFF	9	YIL058W	(246911..247195)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL057C	0	247899	248393	ON	9	YIL057C	complement(247899..248393)	Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YIL056W	1	249989	251911	ON	9	VHR1	(249989..251911)	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YIL055C	0	252040	253923	ON	9	YIL055C	complement(252040..253923)	Putative protein of unknown function
YIL054W	1	254541	254858	OFF	9	YIL054W	(254541..254858)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL053W	1	255113	255865	ON	9	RHR2	(255113..255865)	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YIL052C	0	256224	257061	ON	9	RPL34B	complement(256224..256552,257025..257061)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YIL051C	0	257842	258279	ON	9	MMF1	complement(257842..258279)	Mitochondrial protein involved in maintenance of the mitochondrial genome
YIL050W	1	258912	259769	ON	9	PCL7	(258912..259769)	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YIL049W	1	260157	260918	ON	9	DFG10	(260157..260918)	Protein of unknown function, involved in filamentous growth
YIL048W	1	261436	264891	ON	9	NEO1	(261436..264891)	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YIL047C-A	0	265098	265466	OFF	9	YIL047C-A	complement(265098..265466)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL047C	0	265114	267822	ON	9	SYG1	complement(265114..267822)	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YIL046W-A	1	268308	268472	OFF	9	YIL046W-A	(268308..268472)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIL046W	1	268650	270572	ON	9	MET30	(268650..270572)	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
YIL045W	1	271160	272776	ON	9	PIG2	(271160..272776)	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YIL044C	0	272949	273845	ON	9	AGE2	complement(272949..273845)	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
YIL043C	0	274071	274925	ON	9	CBR1	complement(274071..274925)	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YIL042C	0	275107	276291	ON	9	PKP1	complement(275107..276291)	Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1p
YIL041W	1	276524	277504	ON	9	GVP36	(276524..277504)	Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments
YIL040W	1	277722	278138	ON	9	APQ12	(277722..278138)	Protein involved in nucleocytoplasmic transport of mRNA
YIL039W	1	278425	279846	ON	9	YIL039W	(278425..279846)	Putative protein of unknown function; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YIL038C	0	280141	282651	ON	9	NOT3	complement(280141..282651)	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YIL037C	0	283028	284998	ON	9	PRM2	complement(283028..284998)	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YIL036W	1	285665	287428	ON	9	CST6	(285665..287428)	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
YIL035C	0	287789	288907	ON	9	CKA1	complement(287789..288907)	Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YIL034C	0	289225	290088	ON	9	CAP2	complement(289225..290088)	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YIL033C	0	290418	291668	ON	9	BCY1	complement(290418..291668)	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YIL032C	0	291960	292316	OFF	9	YIL032C	complement(291960..292316)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL031W	1	292632	295736	ON	9	ULP2	(292632..295736)	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
YIL030W-A	1	295564	295902	OFF	9	YIL030W-A	(295564..295902)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIL031W.
YIL030C	0	296049	300008	ON	9	SSM4	complement(296049..300008)	Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YIL029W-A	1	299734	300105	OFF	9	YIL029W-A	(299734..300105)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL029C	0	300827	301255	ON	9	YIL029C	complement(300827..301255)	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YIL028W	1	302098	302496	OFF	9	YIL028W	(302098..302496)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL027C	0	303677	304102	ON	9	KRE27	complement(303677..304102)	Protein of unknown function; null mutant shows K1 killer toxin resistance
YIL026C	0	304475	307927	ON	9	IRR1	complement(304475..307927)	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YIL025C	0	308199	308573	OFF	9	YIL025C	complement(308199..308573)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL024C	0	308600	309169	ON	9	YIL024C	complement(308600..309169)	Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YIL023C	0	309384	310424	ON	9	YKE4	complement(309384..310424)	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YIL022W	1	311163	312458	ON	9	TIM44	(311163..312458)	Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane
YIL021W	1	312903	313859	ON	9	RPB3	(312903..313859)	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YIL021C-A	0	313197	313466	OFF	9	YIL021C-A	complement(313197..313466)	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching
YIL020C-A	0	313711	314049	OFF	9	YIL020C-A	complement(313711..314049)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL020C	0	314033	314818	ON	9	HIS6	complement(314033..314818)	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YIL019W	1	315091	316131	ON	9	FAF1	(315091..316131)	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YIL018W	1	316766	317930	ON	9	RPL2B	(316766..316769,317170..317930)	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YIL017C	0	318198	320963	ON	9	VID28	complement(318198..320963)	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
YIL016W	1	321452	321931	ON	9	SNL1	(321452..321931)	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YIL015W	1	322340	324103	ON	9	BAR1	(322340..324103)	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YIL014C-A	0	325210	325524	ON	9	YIL014C-A	complement(325210..325524)	Putative protein of unknown function
YIL014W	1	326101	327993	ON	9	MNT3	(326101..327993)	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
YIL013C	0	328205	332440	ON	9	PDR11	complement(328205..332440)	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
YIL012W	1	333009	333401	OFF	9	YIL012W	(333009..333401)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL011W	1	333724	334533	ON	9	TIR3	(333724..334533)	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YIL010W	1	334879	335526	ON	9	DOT5	(334879..335526)	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
YIL009C-A	0	335663	336209	ON	9	EST3	complement(335663..335932,335934..336209)	Component of the telomerase holoenzyme, involved in telomere replication
YIL009W	1	339341	341425	ON	9	FAA3	(339341..341425)	Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YIL008W	1	342533	342832	ON	9	URM1	(342533..342832)	Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YIL007C	0	342991	343653	ON	9	NAS2	complement(342991..343653)	Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p
YIL006W	1	344059	345180	ON	9	YIA6	(344059..345180)	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
YIL005W	1	345689	347794	ON	9	EPS1	(345689..347794)	Pdi1p (protein disulfide isomerase)-related protein involved in endoplasmic reticulum retention of resident ER proteins
YIL004C	0	347943	348502	ON	9	BET1	complement(347943..348360,348492..348502)	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YIL003W	1	349119	350000	ON	9	CFD1	(349119..350000)	Highly conserved, putative P-loop ATPase localized in the cytoplasm; has a potential role in assembly of iron-sulfur clusters in proteins
YIL002W-A	1	350298	350507	ON	9	YIL002W-A	(350298..350507)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIL002C	0	350588	353428	ON	9	INP51	complement(350588..353428)	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
YIL001W	1	353937	355478	ON	9	YIL001W	(353937..355478)	Hypothetical protein
YIR001C	0	356140	356892	ON	9	SGN1	complement(356140..356892)	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
YIR002C	0	357412	360393	ON	9	MPH1	complement(357412..360393)	Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype
YIR003W	1	360882	362921	ON	9	YIR003W	(360882..362921)	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with with the SH3 domain of Abp1p
YIR004W	1	363218	364516	ON	9	DJP1	(363218..364516)	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
YIR005W	1	364886	365332	ON	9	IST3	(364886..365332)	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
YIR006C	0	365463	369905	ON	9	PAN1	complement(365463..369905)	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YIR007W	1	370701	372995	ON	9	YIR007W	(370701..372995)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YIR008C	0	373074	374303	ON	9	PRI1	complement(373074..374303)	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YIR009W	1	374522	374857	ON	9	MSL1	(374522..374857)	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members
YIR010W	1	375428	377158	ON	9	DSN1	(375428..377158)	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YIR011C	0	377284	378243	ON	9	STS1	complement(377284..378243)	Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation
YIR012W	1	378483	379778	ON	9	SQT1	(378483..379778)	Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YIR013C	0	380016	380381	ON	9	GAT4	complement(380016..380381)	Protein containing GATA family zinc finger motifs
YIR014W	1	381083	381811	ON	9	YIR014W	(381083..381811)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YIR015W	1	381945	382379	ON	9	RPR2	(381945..382379)	Subunit of nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits
YIR016W	1	382625	383422	ON	9	YIR016W	(382625..383422)	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR016W is a non-essential gene
YIR017C	0	383553	384116	ON	9	MET28	complement(383553..384116)	Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YIR017W-A	1	383563	384162	OFF	9	YIR017W-A	(383563..384162)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR018W	1	384606	385343	ON	9	YAP5	(384606..385343)	Basic leucine zipper (bZIP) transcription factor
YIR018C-A	0	385561	385698	OFF	9	YIR018C-A	complement(385561..385698)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIR019C	0	389569	393672	ON	9	MUC1	complement(389569..393672)	GPI-anchored cell surface glycoprotein (flocculin) required for diploid pseudohyphal formation and haploid invasive growth, transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YIR020C	0	394252	394554	OFF	9	YIR020C	complement(394252..394554)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR020W-A	1	394914	395156	OFF	9	YIR020W-A	(394914..395156)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YIR020C-B	0	397212	397946	OFF	9	YIR020C-B	complement(397212..397946)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1
YIR021W	1	397291	398382	ON	9	MRS1	(397291..398382)	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YIR021W-A	1	398511	398723	OFF	9	YIR021W-A	(398511..398723)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YIR022W	1	398730	399233	ON	9	SEC11	(398730..399233)	18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
YIR023W	1	399774	402686	ON	9	DAL81	(399774..402686)	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YIR023C-A	0	402380	402703	OFF	9	YIR023C-A	complement(402380..402703)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR024C	0	402838	403488	ON	9	YIR024C	complement(402838..403488)	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
YIR025W	1	403656	404762	ON	9	MND2	(403656..404762)	Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division
YIR026C	0	404870	405964	ON	9	YVH1	complement(404870..405964)	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YIR027C	0	406257	407639	ON	9	DAL1	complement(406257..407639)	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YIR028W	1	408465	410372	ON	9	DAL4	(408465..410372)	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YIR029W	1	410804	411835	ON	9	DAL2	(410804..411835)	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YIR030C	0	412033	412767	ON	9	DCG1	complement(412033..412767)	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YIR030W-A	1	412896	413279	OFF	9	YIR030W-A	(412896..413279)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR031C	0	413012	414676	ON	9	DAL7	complement(413012..414676)	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YIR032C	0	415027	415614	ON	9	DAL3	complement(415027..415614)	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YIR033W	1	416121	419462	ON	9	MGA2	(416121..419462)	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YIR034C	0	419612	420733	ON	9	LYS1	complement(419612..420733)	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YIR035C	0	421023	421787	ON	9	YIR035C	complement(421023..421787)	Putative cytoplasmic protein of unknown function
YIR036C	0	422071	422862	ON	9	YIR036C	complement(422071..422862)	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52 foci
YIR036W-A	1	422632	423033	OFF	9	YIR036W-A	(422632..423033)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR037W	1	423125	423616	ON	9	HYR1	(423125..423616)	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
YIR038C	0	423806	424510	ON	9	GTT1	complement(423806..424510)	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YIR039C	0	430494	432107	ON	9	YPS6	complement(430494..432107)	Putative GPI-anchored aspartic protease
YIR040C	0	433385	433717	OFF	9	YIR040C	complement(433385..433717)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YIR041W	1	433925	434299	ON	9	PAU15	(433925..434299)	Hypothetical protein
YIR042C	0	435270	435980	ON	9	YIR042C	complement(435270..435980)	Putative protein of unknown function; YIR042C is a non-essential gene
YIR043C	0	437040	437732	OFF	9	YIR043C	complement(437040..437732)	Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
YIR044C	0	437991	438176	ON	9	YIR044C	complement(437991..438176)	Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family
YJL225C	0	466	6130	ON	10	YJL225C	complement(466..4581,4970..6130)	Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors
YJL225W-A	1	829	1311	OFF	10	YJL225W-A	(829..1311)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C
YJL223C	0	8776	9138	ON	10	PAU1	complement(8776..9138)	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YJL222W-B	1	9346	9483	OFF	10	YJL222W-B	(9346..9483)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL222W-A	1	9452	9679	OFF	10	YJL222W-A	(9452..9679)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL222W	1	11475	16124	ON	10	VTH2	(11475..16124)	Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YJL221C	0	16767	18536	ON	10	FSP2	complement(16767..18536)	Protein of unknown function, expression is induced during nitrogen limitation
YJL220W	1	18243	18695	OFF	10	YJL220W	(18243..18695)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YJL219W	1	19497	21200	ON	10	HXT9	(19497..21200)	Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YJL218W	1	21973	22563	ON	10	YJL218W	(21973..22563)	Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YJL217W	1	23133	23729	ON	10	YJL217W	(23133..23729)	Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YJL216C	0	24341	26086	ON	10	YJL216C	complement(24341..26086)	Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YJL215C	0	26412	26771	OFF	10	YJL215C	complement(26412..26771)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL214W	1	26887	28596	ON	10	HXT8	(26887..28596)	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YJL213W	1	32163	33158	ON	10	YJL213W	(32163..33158)	Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YJL212C	0	33850	36249	ON	10	OPT1	complement(33850..36249)	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YJL211C	0	36757	37200	OFF	10	YJL211C	complement(36757..37200)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
YJL210W	1	36919	37734	ON	10	PEX2	(36919..37734)	RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YJL209W	1	38005	39969	ON	10	CBP1	(38005..39969)	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p
YJL208C	0	40194	41183	ON	10	NUC1	complement(40194..41183)	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YJL207C	0	41389	47433	ON	10	LAA1	complement(41389..47433)	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
YJL206C	0	47659	49935	ON	10	YJL206C	complement(47659..49935)	Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
YJL205C	0	50139	50443	ON	10	NCE101	complement(50139..50268,50412..50443)	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
YJL204C	0	50629	53151	ON	10	RCY1	complement(50629..53151)	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
YJL203W	1	53341	54183	ON	10	PRP21	(53341..54183)	Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YJL202C	0	53943	54290	OFF	10	YJL202C	complement(53943..54290)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
YJL201W	1	54379	56178	ON	10	ECM25	(54379..56178)	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YJL200C	0	56444	58813	ON	10	ACO2	complement(56444..58813)	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YJL199C	0	59855	60181	OFF	10	MBB1	complement(59855..60181)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YJL198W	1	60843	63488	ON	10	PHO90	(60843..63488)	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YJL197W	1	63804	67568	ON	10	UBP12	(63804..67568)	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
YJL197C-A	0	65804	66085	OFF	10	YJL197C-A	complement(65804..66085)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12
YJL196C	0	67849	68781	ON	10	ELO1	complement(67849..68781)	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YJL195C	0	69240	69941	OFF	10	YJL195C	complement(69240..69941)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
YJL194W	1	69337	70878	ON	10	CDC6	(69337..70878)	Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
YJL193W	1	71365	72573	ON	10	YJL193W	(71365..72573)	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YJL192C	0	72709	73413	ON	10	SOP4	complement(72709..73413)	ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
YJL191W	1	73786	74610	ON	10	RPS14B	(73786..73795,74204..74610)	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins
YJL190C	0	74909	75301	ON	10	RPS22A	complement(74909..75301)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YJL189W	1	75932	76473	ON	10	RPL39	(75932..75937,76324..76473)	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; exhibits genetic interactions with SIS1 and PAB1
YJL188C	0	76201	76509	OFF	10	BUD19	complement(76201..76509)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YJL187C	0	76802	79261	ON	10	SWE1	complement(76802..79261)	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YJL186W	1	80153	81913	ON	10	MNN5	(80153..81913)	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YJL185C	0	82093	82974	ON	10	YJL185C	complement(82093..82974)	Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
YJL184W	1	83446	83817	ON	10	GON7	(83446..83817)	Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p
YJL183W	1	84066	85334	ON	10	MNN11	(84066..85334)	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
YJL182C	0	85433	85750	OFF	10	YJL182C	complement(85433..85750)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W
YJL181W	1	85658	87493	ON	10	YJL181W	(85658..87493)	Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis
YJL180C	0	87581	88558	ON	10	ATP12	complement(87581..88558)	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YJL179W	1	88785	89114	ON	10	PFD1	(88785..89114)	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YJL178C	0	89280	90095	ON	10	ATG27	complement(89280..90095)	Type II membrane protein involved in autophagy; binds phosphatidylinositol 3-phosphate, required for the cytoplasm-to-vacuole targeting (Cvt) pathway
YJL177W	1	90784	91655	ON	10	RPL17B	(90784..91092,91410..91655)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YJL176C	0	92051	94528	ON	10	SWI3	complement(92051..94528)	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YJL175W	1	94047	94559	OFF	10	YJL175W	(94047..94559)	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
YJL174W	1	95090	95920	ON	10	KRE9	(95090..95920)	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
YJL173C	0	96159	96527	ON	10	RFA3	complement(96159..96527)	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YJL172W	1	97731	99461	ON	10	CPS1	(97731..99461)	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YJL171C	0	99698	100888	ON	10	YJL171C	complement(99698..100888)	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
YJL170C	0	101144	101773	ON	10	ASG7	complement(101144..101773)	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
YJL169W	1	102093	102461	OFF	10	YJL169W	(102093..102461)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YJL168C	0	102221	104422	ON	10	SET2	complement(102221..104422)	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YJL167W	1	105008	106066	ON	10	ERG20	(105008..106066)	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YJL166W	1	106428	106712	ON	10	QCR8	(106428..106712)	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YJL165C	0	106888	109455	ON	10	HAL5	complement(106888..109455)	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
YJL164C	0	109960	111153	ON	10	TPK1	complement(109960..111153)	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
YJL163C	0	111662	113329	ON	10	YJL163C	complement(111662..113329)	Putative protein of unknown function
YJL162C	0	113874	115625	ON	10	JJJ2	complement(113874..115625)	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJL161W	1	117241	117783	ON	10	YJL161W	(117241..117783)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL160C	0	117958	118821	ON	10	YJL160C	complement(117958..118821)	Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis
YJL159W	1	120445	121686	ON	10	HSP150	(120445..121686)	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YJL158C	0	122261	122944	ON	10	CIS3	complement(122261..122944)	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YJL157C	0	123832	126324	ON	10	FAR1	complement(123832..126324)	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YJL156W-A	1	126600	126821	OFF	10	YJL156W-A	(126600..126821)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL156C	0	126886	128949	ON	10	SSY5	complement(126886..128949)	Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes
YJL155C	0	129282	130640	ON	10	FBP26	complement(129282..130640)	Fructose-2,6-bisphosphatase, required for glucose metabolism
YJL154C	0	131098	133932	ON	10	VPS35	complement(131098..133932)	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
YJL153C	0	134329	135930	ON	10	INO1	complement(134329..135930)	Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YJL152W	1	136171	136530	OFF	10	YJL152W	(136171..136530)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL151C	0	136369	136770	ON	10	SNA3	complement(136369..136770)	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YJL150W	1	137120	137422	OFF	10	YJL150W	(137120..137422)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL149W	1	137376	139367	ON	10	YJL149W	(137376..139367)	Putative SCF ubiquitin ligase F-box protein of unknown function; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; YJL149W is a non-essential gene
YJL148W	1	140434	141135	ON	10	RPA34	(140434..141135)	RNA polymerase I subunit A34.5
YJL147C	0	141416	142564	ON	10	YJL147C	complement(141416..142564)	Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
YJL146W	1	143289	144698	ON	10	IDS2	(143289..144698)	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
YJL145W	1	145157	146041	ON	10	SFH5	(145157..146041)	Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, mainly localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YJL144W	1	146356	146670	ON	10	YJL144W	(146356..146670)	Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YJL143W	1	147098	147574	ON	10	TIM17	(147098..147574)	Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import
YJL142C	0	147816	148208	OFF	10	YJL142C	complement(147816..148208)	Hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
YJL141C	0	147964	150387	ON	10	YAK1	complement(147964..150387)	Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
YJL140W	1	150958	151623	ON	10	RPB4	(150958..151623)	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
YJL139C	0	151710	152996	ON	10	YUR1	complement(151710..152996)	Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus
YJL138C	0	153501	154688	ON	10	TIF2	complement(153501..154688)	Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YJL137C	0	154982	156124	ON	10	GLG2	complement(154982..156124)	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YJL136W-A	1	156166	156249	OFF	10	YJL136W-A	(156166..156249)	Identified by SAGE
YJL136C	0	156547	157270	ON	10	RPS21B	complement(156547..156786,157247..157270)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YJL135W	1	157874	158191	OFF	10	YJL135W	(157874..158191)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YJL134W	1	158185	159414	ON	10	LCB3	(158185..159414)	Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
YJL133C-A	0	159620	159844	ON	10	YJL133C-A	complement(159620..159844)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL133W	1	160616	161560	ON	10	MRS3	(160616..161560)	Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs4p; functions under low-iron conditions; may transport other cations in addition to iron
YJL132W	1	161911	164163	ON	10	YJL132W	(161911..164163)	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
YJL131C	0	164275	165345	ON	10	YJL131C	complement(164275..165345)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL131C is not an essential gene
YJL130C	0	165720	172364	ON	10	URA2	complement(165720..172364)	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YJL129C	0	173596	177303	ON	10	TRK1	complement(173596..177303)	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
YJL128C	0	178094	180100	ON	10	PBS2	complement(178094..180100)	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress
YJL127W-A	1	180191	180307	OFF	10	YJL127W-A	(180191..180307)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL127C-B	0	181549	181707	ON	10	YJL127C-B	complement(181549..181707)	Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>
YJL127C	0	182296	184218	ON	10	SPT10	complement(182296..184218)	Putative histone acetylase, sequence-specific activator of histone genes, binds specifically and highly cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
YJL126W	1	184499	185422	ON	10	NIT2	(184499..185422)	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YJL125C	0	185526	186677	ON	10	GCD14	complement(185526..186677)	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YJL124C	0	187125	187643	ON	10	LSM1	complement(187125..187643)	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
YJL123C	0	188003	189439	ON	10	YJL123C	complement(188003..189439)	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); YJL123C is a non-essential gene
YJL122W	1	189715	190242	ON	10	ALB1	(189715..190242)	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YJL121C	0	190373	191089	ON	10	RPE1	complement(190373..191089)	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YJL120W	1	191021	191344	OFF	10	YJL120W	(191021..191344)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
YJL119C	0	191571	191894	OFF	10	YJL119C	complement(191571..191894)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL118W	1	191638	192297	ON	10	YJL118W	(191638..192297)	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
YJL117W	1	192530	193465	ON	10	PHO86	(192530..193465)	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
YJL116C	0	193859	194872	ON	10	NCA3	complement(193859..194872)	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YJL115W	1	196285	197124	ON	10	ASF1	(196285..197124)	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
YJL112W	1	205301	207445	ON	10	MDV1	(205301..207445)	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YJL111W	1	207873	209525	ON	10	CCT7	(207873..209525)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL110C	0	209918	211573	ON	10	GZF3	complement(209918..211573)	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
YJL109C	0	211996	217305	ON	10	UTP10	complement(211996..217305)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJL108C	0	217701	218852	ON	10	PRM10	complement(217701..218852)	Pheromone-regulated protein, predicted to have 5 transmembrane segments
YJL107C	0	218849	220012	OFF	10	YJL107C	complement(218849..220012)	Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YJL106W	1	221386	223323	ON	10	IME2	(221386..223323)	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YJL105W	1	225051	226733	ON	10	SET4	(225051..226733)	Protein of unknown function, contains a SET domain
YJL104W	1	227323	227772	ON	10	PAM16	(227323..227772)	Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain
YJL103C	0	229021	230877	ON	10	YJL103C	complement(229021..230877)	Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YJL102W	1	231297	233756	ON	10	MEF2	(231297..233756)	Mitochondrial elongation factor involved in translational elongation
YJL101C	0	234316	236352	ON	10	GSH1	complement(234316..236352)	Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YJL100W	1	237259	239082	ON	10	LSB6	(237259..239082)	Phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YJL099W	1	239410	241650	ON	10	CHS6	(239410..241650)	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane
YJL098W	1	242078	245254	ON	10	SAP185	(242078..245254)	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YJL097W	1	245587	246240	ON	10	PHS1	(245587..246240)	Protein of unknown function; homolog of mammalian PTPLA; involved in sphingolipid biosynthesis, protein trafficking; required for cell viability
YJL096W	1	246486	246971	ON	10	MRPL49	(246486..246971)	Mitochondrial ribosomal protein of the large subunit
YJL095W	1	247250	251686	ON	10	BCK1	(247250..251686)	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
YJL094C	0	251816	254437	ON	10	KHA1	complement(251816..254437)	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
YJL093C	0	254732	256807	ON	10	TOK1	complement(254732..256807)	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YJL092W	1	257418	260942	ON	10	SRS2	(257418..260942)	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
YJL091C	0	261075	262547	ON	10	GWT1	complement(261075..262547)	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YJL090C	0	262752	265046	ON	10	DPB11	complement(262752..265046)	Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YJL089W	1	265921	268410	ON	10	SIP4	(265921..268410)	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YJL088W	1	268794	269810	ON	10	ARG3	(268794..269810)	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
YJL087C	0	269997	272480	ON	10	TRL1	complement(269997..272480)	tRNA ligase, required for tRNA splicing; composed of three essential domains containing the phosphodiesterase, polynucleotide kinase, and ligase activities required for ligation; localized at the inner membrane of the nuclear envelope
YJL086C	0	272473	272841	OFF	10	YJL086C	complement(272473..272841)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
YJL085W	1	272822	274693	ON	10	EXO70	(272822..274693)	Essential 70kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YJL084C	0	274857	277997	ON	10	YJL084C	complement(274857..277997)	Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YJL083W	1	278836	280650	ON	10	TAX4	(278836..280650)	Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p
YJL082W	1	281180	283375	ON	10	IML2	(281180..283375)	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL081C	0	283797	285266	ON	10	ARP4	complement(283797..285266)	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YJL080C	0	285553	289221	ON	10	SCP160	complement(285553..289221)	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YJL079C	0	289870	290769	ON	10	PRY1	complement(289870..290769)	Protein of unknown function, has similarity to Pry2p and Pry3p and to the plant PR-1 class of pathogen related proteins
YJL078C	0	291331	293976	ON	10	PRY3	complement(291331..293976)	Protein of unknown function, has similarity to Pry1p and Pry2p and to the plant PR-1 class of pathogen related proteins
YJL077W-B	1	294042	294140	OFF	10	YJL077W-B	(294042..294140)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJL077C	0	294661	295056	OFF	10	ICS3	complement(294661..295056)	Protein of unknown function
YJL077W-A	1	294794	294880	OFF	10	YJL077W-A	(294794..294880)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL077C/ICS3
YJL076W	1	295240	298809	ON	10	NET1	(295240..298809)	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
YJL075C	0	298455	298871	OFF	10	APQ13	complement(298455..298871)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
YJL074C	0	299152	302844	ON	10	SMC3	complement(299152..302844)	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YJL073W	1	303176	305113	ON	10	JEM1	(303176..305113)	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
YJL072C	0	305216	305857	ON	10	PSF2	complement(305216..305857)	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YJL071W	1	306127	307851	ON	10	ARG2	(306127..307851)	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p
YJL070C	0	307966	310632	ON	10	YJL070C	complement(307966..310632)	Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene
YJL069C	0	310917	312701	ON	10	UTP18	complement(310917..312701)	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YJL068C	0	313011	313910	ON	10	YJL068C	complement(313011..313910)	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YJL067W	1	314079	314429	OFF	10	YJL067W	(314079..314429)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL066C	0	314109	314867	ON	10	MPM1	complement(314109..314867)	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
YJL065C	0	315049	315552	ON	10	DLS1	complement(315049..315552)	Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing
YJL064W	1	315170	315565	OFF	10	YJL064W	(315170..315565)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
YJL063C	0	315754	316470	ON	10	MRPL8	complement(315754..316470)	Mitochondrial ribosomal protein of the large subunit
YJL062W-A	1	316718	316975	ON	10	YJL062W-A	(316718..316975)	Putative protein of unknown function, identified based on comparison to related yeast species; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL062W	1	317279	319771	ON	10	LAS21	(317279..319771)	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
YJL061W	1	320011	322152	ON	10	NUP82	(320011..322152)	Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC
YJL060W	1	323381	324715	ON	10	BNA3	(323381..324715)	Arylformamidase, involved in biosynthesis of nicotinic acid from tryptophan via kynurenine pathway; potential Cdc28p substrate
YJL059W	1	324959	326185	ON	10	YHC3	(324959..326185)	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
YJL058C	0	326237	327868	ON	10	BIT61	complement(326237..327868)	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
YJL057C	0	328113	330116	ON	10	IKS1	complement(328113..330116)	Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
YJL056C	0	330426	333068	ON	10	ZAP1	complement(330426..333068)	Zinc-regulated transcription factor, binds to zinc-responsive promoter elements to induce transcription of certain genes in the presence of zinc; regulates its own transcription; contains seven zinc-finger domains
YJL055W	1	333352	334089	ON	10	YJL055W	(333352..334089)	Putative protein of unknown function; deletion mutants are sensitive to purine base analogs, 6-hydroxylaminopurine (HAP) and 2-amino-6-hydroxylaminopurine (AHA) and are AHA-hypermutable
YJL054W	1	334260	335696	ON	10	TIM54	(334260..335696)	Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane
YJL053W	1	335893	337032	ON	10	PEP8	(335893..337032)	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport
YJL052C-A	0	337879	337998	OFF	10	YJL052C-A	complement(337879..337998)	Putative protein of unknown function, identified based on comparison to related yeast species
YJL052W	1	338266	339264	ON	10	TDH1	(338266..339264)	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YJL051W	1	339782	342250	ON	10	YJL051W	(339782..342250)	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52 foci
YJL050W	1	342517	345738	ON	10	MTR4	(342517..345738)	Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
YJL049W	1	345968	347320	ON	10	YJL049W	(345968..347320)	Putative protein of unknown function; YJL049W is a non-essential gene
YJL048C	0	347442	348632	ON	10	UBX6	complement(347442..348632)	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YJL047C-A	0	349039	349173	OFF	10	YJL047C-A	complement(349039..349173)	Putative protein of unknown function
YJL047C	0	349575	352103	ON	10	RTT101	complement(349575..352103)	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p
YJL046W	1	352381	353610	ON	10	YJL046W	(352381..353610)	Putative protein of unknown function, predicted to encode a lipoate-protein ligase A family member; deletion mutant has a respiratory growth defect
YJL045W	1	356019	357923	ON	10	YJL045W	(356019..357923)	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YJL044C	0	358295	359671	ON	10	GYP6	complement(358295..359671)	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
YJL043W	1	360125	360898	ON	10	YJL043W	(360125..360898)	Putative protein of unknown function; YJL043W is a non-essential gene
YJL042W	1	361244	365440	ON	10	MHP1	(361244..365440)	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YJL041W	1	365779	368368	ON	10	NSP1	(365779..365779,365898..368368)	Essential component of the nuclear pore complex, which mediates nuclear import and export
YJL039C	0	368743	373794	ON	10	NUP192	complement(368743..373794)	Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YJL038C	0	375110	375769	ON	10	YJL038C	complement(375110..375769)	Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YJL037W	1	376657	377331	ON	10	YJL037W	(376657..377331)	Putative protein of unknown function; expression induced in respiratory-deficient petite cells, in carbon-limited chemostat cultures, during meiosis, sporulation and after alpha factor treatment; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52 foci
YJL036W	1	378820	380091	ON	10	SNX4	(378820..380091)	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p
YJL035C	0	380244	380996	ON	10	TAD2	complement(380244..380996)	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YJL034W	1	381322	383370	ON	10	KAR2	(381322..383370)	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
YJL033W	1	383832	386144	ON	10	HCA4	(383832..386144)	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YJL032W	1	386343	386657	OFF	10	YJL032W	(386343..386657)	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
YJL031C	0	386363	387433	ON	10	BET4	complement(386363..387343,387431..387433)	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YJL030W	1	387652	388242	ON	10	MAD2	(387652..388242)	Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
YJL029C	0	388380	390848	ON	10	VPS53	complement(388380..390848)	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YJL028W	1	391306	391641	OFF	10	YJL028W	(391306..391641)	Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YJL027C	0	391828	392244	OFF	10	YJL027C	complement(391828..392244)	Putative protein of unknown function
YJL026W	1	392399	393598	ON	10	RNR2	(392399..393598)	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YJL026C-A	0	393061	393282	OFF	10	YJL026C-A	complement(393061..393282)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YJL025W	1	393962	395506	ON	10	RRN7	(393962..395506)	Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YJL024C	0	395926	396587	ON	10	APS3	complement(395926..396488,396566..396587)	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
YJL023C	0	397350	398393	ON	10	PET130	complement(397350..398393)	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL022W	1	398104	398412	OFF	10	YJL022W	(398104..398412)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
YJL020C	0	398932	402405	ON	10	BBC1	complement(398932..402405)	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YJL020W-A	1	400976	401233	OFF	10	YJL020W-A	(400976..401233)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1
YJL019W	1	402892	404940	ON	10	MPS3	(402892..404940)	Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p
YJL016W	1	405583	407268	ON	10	YJL016W	(405583..407268)	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
YJL015C	0	407137	407511	OFF	10	YJL015C	complement(407137..407511)	Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
YJL014W	1	407552	409156	ON	10	CCT3	(407552..409156)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL013C	0	409487	411034	ON	10	MAD3	complement(409487..411034)	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
YJL012C	0	411228	413393	ON	10	VTC4	complement(411228..413393)	Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YJL011C	0	414279	414764	ON	10	RPC17	complement(414279..414764)	RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YJL010C	0	417556	419556	ON	10	YJL010C	complement(417556..419556)	Essential nucleolar protein required for 18S rRNA synthesis
YJL009W	1	419849	420175	OFF	10	YJL009W	(419849..420175)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YJL008C	0	419951	421657	ON	10	CCT8	complement(419951..421657)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJL007C	0	422692	423006	OFF	10	YJL007C	complement(422692..423006)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL006C	0	423132	424103	ON	10	CTK2	complement(423132..424103)	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YJL005W	1	425151	431231	ON	10	CYR1	(425151..431231)	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YJL004C	0	431583	432194	ON	10	SYS1	complement(431583..432194)	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YJL003W	1	432638	432994	ON	10	COX16	(432638..432994)	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
YJL002C	0	433215	434645	ON	10	OST1	complement(433215..434645)	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YJL001W	1	435157	435920	ON	10	PRE3	(435157..435221,435338..435920)	20S proteasome beta-type subunit, responsible for cleavage after acidic residues in peptides
YJR001W	1	436796	438604	ON	10	AVT1	(436796..438604)	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YJR002W	1	438858	440639	ON	10	MPP10	(438858..440639)	Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YJR003C	0	440987	442546	ON	10	YJR003C	complement(440987..442546)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR004C	0	442902	444854	ON	10	SAG1	complement(442902..444854)	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YJR005W	1	445916	448018	ON	10	APL1	(445916..448018)	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
YJR005C-A	0	448470	448751	ON	10	YJR005C-A	complement(448470..448751)	Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene
YJR006W	1	449195	450658	ON	10	POL31	(449195..450658)	DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
YJR007W	1	451013	451927	ON	10	SUI2	(451013..451927)	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YJR008W	1	452423	453439	ON	10	YJR008W	(452423..453439)	Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YJR009C	0	453676	454674	ON	10	TDH2	complement(453676..454674)	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YJR010W	1	456232	457767	ON	10	MET3	(456232..457767)	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YJR010C-A	0	458070	458354	ON	10	SPC1	complement(458070..458354)	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
YJR011C	0	458634	459419	ON	10	YJR011C	complement(458634..459419)	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YJR012C	0	459788	460411	ON	10	YJR012C	complement(459788..460411)	Putative protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
YJR013W	1	460375	461586	ON	10	GPI14	(460375..461586)	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
YJR014W	1	461822	462418	ON	10	TMA22	(461822..462418)	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; has homology to human protein DRP1, which interacts with human Tma20p homolog MCT-1
YJR015W	1	462714	464246	ON	10	YJR015W	(462714..464246)	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
YJR016C	0	464444	466201	ON	10	ILV3	complement(464444..466201)	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YJR017C	0	466514	467026	ON	10	ESS1	complement(466514..467026)	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
YJR018W	1	466779	467141	OFF	10	YJR018W	(466779..467141)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR019C	0	467225	468274	ON	10	TES1	complement(467225..468274)	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YJR020W	1	467994	468326	OFF	10	YJR020W	(467994..468326)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR021C	0	468548	469572	ON	10	REC107	complement(468548..469176,469257..469572)	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
YJR022W	1	469777	470106	ON	10	LSM8	(469777..470106)	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YJR023C	0	469797	470198	OFF	10	YJR023C	complement(469797..470198)	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
YJR024C	0	470223	470957	ON	10	YJR024C	complement(470223..470957)	Putative methylthio-ribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
YJR025C	0	471131	471664	ON	10	BNA1	complement(471131..471664)	3-hydroxyanthranilic acid dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YJR030C	0	483952	486189	ON	10	YJR030C	complement(483952..486189)	Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene
YJR031C	0	486579	490805	ON	10	GEA1	complement(486579..490805)	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p
YJR032W	1	491074	492255	ON	10	CPR7	(491074..492255)	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YJR033C	0	492371	496444	ON	10	RAV1	complement(492371..496444)	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
YJR034W	1	496676	497002	ON	10	PET191	(496676..497002)	Protein required for assembly of cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR035W	1	497348	500605	ON	10	RAD26	(497348..500605)	Protein involved in transcription-coupled repair nucleotide excision repair of UV-induced DNA lesions; homolog of human CSB protein
YJR036C	0	500706	503384	ON	10	HUL4	complement(500706..503384)	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YJR037W	1	503095	503478	OFF	10	YJR037W	(503095..503478)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene.
YJR038C	0	503703	504065	OFF	10	YJR038C	complement(503703..504065)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR039W	1	503929	507294	ON	10	YJR039W	(503929..507294)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR040W	1	507739	510078	ON	10	GEF1	(507739..510078)	Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
YJR041C	0	510232	513756	ON	10	URB2	complement(510232..513756)	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
YJR042W	1	514048	516282	ON	10	NUP85	(514048..516282)	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
YJR043C	0	516454	517506	ON	10	POL32	complement(516454..517506)	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YJR044C	0	518756	519178	ON	10	VPS55	complement(518756..519178)	Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
YJR045C	0	519631	521595	ON	10	SSC1	complement(519631..521595)	Mitochondrial matrix ATPase; subunit of the presequence translocase-associated protein import motor (PAM) and of the SceI endonuclease; involved in protein translocation into the matrix and protein folding; member of HSP70 family
YJR046W	1	522041	523855	ON	10	TAH11	(522041..523855)	DNA replication licensing factor, required for pre-replication complex assembly
YJR047C	0	524901	525374	ON	10	ANB1	complement(524901..525374)	Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YJR048W	1	526328	526657	ON	10	CYC1	(526328..526657)	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YJR049C	0	526877	528469	ON	10	UTR1	complement(526877..528469)	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)
YJR050W	1	528690	529397	ON	10	ISY1	(528690..529397)	Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest
YJR051W	1	529854	531359	ON	10	OSM1	(529854..531359)	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity
YJR052W	1	532055	533752	ON	10	RAD7	(532055..533752)	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YJR053W	1	534020	535744	ON	10	BFA1	(534020..535744)	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
YJR054W	1	536049	537542	ON	10	YJR054W	(536049..537542)	Vacuolar protein of unknown function; potential Cdc28p substrate
YJR055W	1	538765	539259	ON	10	HIT1	(538765..539259)	Protein of unknown function, required for growth at high temperature
YJR056C	0	541785	542495	ON	10	YJR056C	complement(541785..542495)	Hypothetical protein
YJR057W	1	544055	544705	ON	10	CDC8	(544055..544705)	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YJR058C	0	544725	545168	ON	10	APS2	complement(544725..545168)	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YJR059W	1	545780	548236	ON	10	PTK2	(545780..548236)	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
YJR060W	1	548752	549807	ON	10	CBF1	(548752..549807)	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA
YJR061W	1	550504	553311	ON	10	YJR061W	(550504..553311)	Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YJR062C	0	553469	554842	ON	10	NTA1	complement(553469..554842)	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
YJR063W	1	555188	555565	ON	10	RPA12	(555188..555565)	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YJR064W	1	555907	557595	ON	10	CCT5	(555907..557595)	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YJR065C	0	557802	559151	ON	10	ARP3	complement(557802..559151)	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YJR066W	1	559409	566821	ON	10	TOR1	(559409..566821)	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
YJR067C	0	567012	567437	ON	10	YAE1	complement(567012..567437)	Essential protein of unknown function
YJR068W	1	567636	568697	ON	10	RFC2	(567636..568697)	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YJR069C	0	568799	569392	ON	10	HAM1	complement(568799..569392)	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
YJR070C	0	569614	570591	ON	10	LIA1	complement(569614..570591)	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YJR071W	1	570398	570766	OFF	10	YJR071W	(570398..570766)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR072C	0	570960	572117	ON	10	NPA3	complement(570960..572117)	Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
YJR073C	0	572308	572928	ON	10	OPI3	complement(572308..572928)	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
YJR074W	1	573088	573744	ON	10	MOG1	(573088..573744)	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
YJR075W	1	573974	575164	ON	10	HOC1	(573974..575164)	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
YJR076C	0	575347	576594	ON	10	CDC11	complement(575347..576594)	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YJR077C	0	577248	578183	ON	10	MIR1	complement(577248..578183)	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2 under normal conditions
YJR078W	1	578853	580214	ON	10	BNA2	(578853..580214)	Tryptophan 2,3-dioxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YJR079W	1	580198	581232	OFF	10	YJR079W	(580198..580340,581046..581232)	Putative protein of unknown function; mutation results in impaired mitochondrial respiration
YJR080C	0	580425	581609	ON	10	YJR080C	complement(580425..581609)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR082C	0	581907	582248	ON	10	EAF6	complement(581907..582248)	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
YJR083C	0	582601	583530	ON	10	ACF4	complement(582601..583530)	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
YJR084W	1	583726	584997	ON	10	CSN12	(583726..584997)	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YJR085C	0	585113	585430	ON	10	YJR085C	complement(585113..585430)	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR086W	1	586061	586393	ON	10	STE18	(586061..586393)	G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YJR087W	1	586393	586743	OFF	10	YJR087W	(586393..586743)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene STE18 and uncharacterized ORF YJR088C
YJR088C	0	586488	587366	ON	10	YJR088C	complement(586488..587366)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YJR089W	1	587711	590575	ON	10	BIR1	(587711..590575)	Essential chromosomal passenger protein involved in coordinating cell cycle events for proper chromosome segregation; C-terminal region binds Sli15p, and the middle region, upon phosphorylation, localizes Cbf2p to the spindle at anaphase
YJR090C	0	590865	594320	ON	10	GRR1	complement(590865..594320)	F-box protein component of the SCF ubiquitin-ligase complex, required for Cln1p and Cln2p degradation; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, and morphogenesis
YJR091C	0	595054	598329	ON	10	JSN1	complement(595054..598329)	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
YJR092W	1	598728	603074	ON	10	BUD4	(598728..603074)	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
YJR093C	0	603216	604199	ON	10	FIP1	complement(603216..604199)	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity
YJR094C	0	604565	605647	ON	10	IME1	complement(604565..605647)	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YJR094W-A	1	608301	608854	ON	10	RPL43B	(608301..608302,608578..608854)	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YJR095W	1	609769	610737	ON	10	SFC1	(609769..610737)	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YJR096W	1	611191	612039	ON	10	YJR096W	(611191..612039)	Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YJR097W	1	612409	612927	ON	10	JJJ3	(612409..612927)	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJR098C	0	613182	615149	ON	10	YJR098C	complement(613182..615149)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR099W	1	615569	616279	ON	10	YUH1	(615569..616279)	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YJR100C	0	616344	617327	ON	10	YJR100C	complement(616344..617327)	Putative protein of unknown function; appears related to murine NOR1, which is highly expressed in leukemogenic cell lines; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR101W	1	618227	619027	ON	10	RSM26	(618227..619027)	Mitochondrial ribosomal protein of the small subunit
YJR102C	0	619150	619758	ON	10	VPS25	complement(619150..619758)	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YJR103W	1	620747	622441	ON	10	URA8	(620747..622441)	Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YJR104C	0	622542	623006	ON	10	SOD1	complement(622542..623006)	Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YJR105W	1	623573	624595	ON	10	ADO1	(623573..624595)	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YJR106W	1	624830	627007	ON	10	ECM27	(624830..627007)	Non-essential protein of unknown function
YJR107W	1	627333	628319	ON	10	YJR107W	(627333..628319)	Putative protein of unknown function; has sequence or structural similarity to lipases
YJR108W	1	628706	629077	ON	10	ABM1	(628706..629077)	Protein of unknown function, required for normal microtubule organization
YJR109C	0	629579	632935	ON	10	CPA2	complement(629579..632935)	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
YJR110W	1	633609	635675	ON	10	YMR1	(633609..635675)	Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family
YJR111C	0	635849	636700	ON	10	YJR111C	complement(635849..636700)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YJR112W	1	637024	637629	ON	10	NNF1	(637024..637629)	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YJR112W-A	1	637784	638162	ON	10	YJR112W-A	(637784..637803,637853..638162)	Putative protein of unknown function; identified based on homology to <i>Ashbya gossypii</i>
YJR113C	0	638226	638969	ON	10	RSM7	complement(638226..638969)	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YJR114W	1	638653	639045	OFF	10	YJR114W	(638653..639045)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YJR115W	1	639936	640445	ON	10	YJR115W	(639936..640445)	Putative protein of unknown function
YJR116W	1	640819	641658	ON	10	YJR116W	(640819..641658)	Putative protein of unknown function
YJR117W	1	642001	643362	ON	10	STE24	(642001..643362)	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
YJR118C	0	643484	644095	ON	10	ILM1	complement(643484..644095)	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YJR119C	0	644298	646484	ON	10	JHD2	complement(644298..646484)	JmjC domain family histone demethylase specific for H3-K4 (lysine at position 4 of the histone H3 protein); removes methyl groups specifically added by Set1p methyltransferase
YJR120W	1	647120	647470	OFF	10	YJR120W	(647120..647470)	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YJR121W	1	647601	649136	ON	10	ATP2	(647601..649136)	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YJR122W	1	649770	651263	ON	10	CAF17	(649770..651263)	Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins
YJR123W	1	651895	652572	ON	10	RPS5	(651895..652572)	Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YJR124C	0	652886	654232	ON	10	YJR124C	complement(652886..654232)	Putative protein of unknown function; expression induced under calcium shortage
YJR125C	0	654731	655957	ON	10	ENT3	complement(654731..655957)	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
YJR126C	0	656248	658683	ON	10	VPS70	complement(656248..658683)	Protein of unknown function involved in vacuolar protein sorting
YJR127C	0	658911	663053	ON	10	RSF2	complement(658911..663053)	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
YJR128W	1	662915	663274	OFF	10	YJR128W	(662915..663274)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YJR129C	0	663994	665013	ON	10	YJR129C	complement(663994..665013)	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJR130C	0	665212	667131	ON	10	STR2	complement(665212..667131)	Cystathionine gamma-synthase, converts cysteine into cystathionine
YJR131W	1	667638	669287	ON	10	MNS1	(667638..669287)	Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane
YJR132W	1	669516	672662	ON	10	NMD5	(669516..672662)	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
YJR133W	1	672985	673614	ON	10	XPT1	(672985..673614)	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YJR134C	0	673723	675846	ON	10	SGM1	complement(673723..675846)	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
YJR135C	0	676053	676772	ON	10	MCM22	complement(676053..676772)	Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner
YJR135W-A	1	676965	677228	ON	10	TIM8	(676965..677228)	Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome
YJR136C	0	677435	678700	ON	10	YJR136C	complement(677435..678700)	Putative protein of unknown function; may interact with mitochondrial ribosomal protein Rsm23p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJR137C	0	678951	683279	ON	10	ECM17	complement(678951..683279)	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YJR138W	1	684561	689315	ON	10	IML1	(684561..689315)	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YJR139C	0	689439	690518	ON	10	HOM6	complement(689439..690518)	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YJR140C	0	690744	695690	ON	10	HIR3	complement(690744..695690)	Transcriptional corepressor involved in the cell cycle-regulated transcription of histone genes HTA1, HTB1, HHT1, and HHT2; involved in position-dependent gene silencing and nucleosome reassembly
YJR140W-A	1	690955	691104	OFF	10	YJR140W-A	(690955..691104)	Dubious open reading frame; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR141W	1	695900	696943	ON	10	YJR141W	(695900..696943)	Putative protein of unknown function; may be involved in mRNA processing; YJR141W is an essential gene
YJR142W	1	697135	698163	ON	10	YJR142W	(697135..698163)	Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion
YJR143C	0	698320	700608	ON	10	PMT4	complement(698320..700608)	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
YJR144W	1	700876	701685	ON	10	MGM101	(700876..701685)	Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YJR145C	0	702021	703062	ON	10	RPS4A	complement(702021..702792,703049..703062)	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YJR146W	1	703879	704232	OFF	10	YJR146W	(703879..704232)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YJR147W	1	704190	705266	ON	10	HMS2	(704190..705266)	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YJR148W	1	705738	706868	ON	10	BAT2	(705738..706868)	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
YJR149W	1	707154	708368	ON	10	YJR149W	(707154..708368)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJR150C	0	708805	709701	ON	10	DAN1	complement(708805..709701)	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJR151C	0	712249	715734	ON	10	DAN4	complement(712249..715734)	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJR151W-A	1	717574	717624	OFF	10	YJR151W-A	(717574..717624)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YJR152W	1	719660	721291	ON	10	DAL5	(719660..721291)	Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YJR153W	1	722809	723894	ON	10	PGU1	(722809..723894)	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YJR154W	1	725778	726818	ON	10	YJR154W	(725778..726818)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJR155W	1	727399	728265	ON	10	AAD10	(727399..728265)	Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YJR156C	0	728568	729590	ON	10	THI11	complement(728568..729590)	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YJR157W	1	730509	730871	OFF	10	YJR157W	(730509..730871)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR158W	1	732434	734137	ON	10	HXT16	(732434..734137)	Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose
YJR159W	1	736038	737111	ON	10	SOR1	(736038..737111)	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YJR160C	0	738002	739810	ON	10	MPH3	complement(738002..739810)	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YJR161C	0	742842	743993	ON	10	COS5	complement(742842..743993)	Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YJR162C	0	744905	745255	OFF	10	YJR162C	complement(744905..745255)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL225W	1	452	799	OFF	11	YKL225W	(452..799)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL224C	0	1811	2182	ON	11	YKL224C	complement(1811..2182)	Putative protein of unknown function
YKL223W	1	2390	2722	OFF	11	YKL223W	(2390..2722)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL222C	0	3504	5621	ON	11	YKL222C	complement(3504..5621)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
YKL221W	1	6108	7529	ON	11	MCH2	(6108..7529)	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YKL220C	0	9092	11227	ON	11	FRE2	complement(9092..11227)	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YKL219W	1	14485	15708	ON	11	COS9	(14485..15708)	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YKL218C	0	17359	18339	ON	11	SRY1	complement(17359..18339)	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YKL217W	1	22234	24084	ON	11	JEN1	(22234..24084)	Lactate transporter, required for uptake of lactate and pyruvate; expression is derepressed by transcriptional activator Cat8p under nonfermentative growth conditions, and repressed in the presence of glucose, fructose, and mannose
YKL216W	1	25216	26160	ON	11	URA1	(25216..26160)	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YKL215C	0	26828	30688	ON	11	YKL215C	complement(26828..30688)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL214C	0	31083	31694	ON	11	YRA2	complement(31083..31694)	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
YKL213C	0	31961	34108	ON	11	DOA1	complement(31961..34108)	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YKL212W	1	34544	36415	ON	11	SAC1	(34544..36415)	Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion
YKL211C	0	36700	38154	ON	11	TRP3	complement(36700..38154)	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YKL210W	1	39164	42238	ON	11	UBA1	(39164..42238)	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
YKL209C	0	42424	46296	ON	11	STE6	complement(42424..46296)	Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YKL208W	1	47158	47973	ON	11	CBT1	(47158..47973)	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YKL207W	1	48195	48956	ON	11	YKL207W	(48195..48956)	Putative protein of unknown function; non-essential gene
YKL206C	0	49007	49810	ON	11	ADD66	complement(49007..49810)	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YKL205W	1	50052	53354	ON	11	LOS1	(50052..53354)	Nuclear pore protein involved in nuclear export of pre-tRNA
YKL204W	1	53705	55603	ON	11	EAP1	(53705..55603)	eIF4E-associated protein, binds eIF4E and inhibits cap-dependent translation, also functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade
YKL203C	0	55936	63360	ON	11	TOR2	complement(55936..63360)	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
YKL202W	1	63822	64403	OFF	11	YKL202W	(63822..64403)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL201C	0	63931	67467	ON	11	MNN4	complement(63931..67467)	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YKL198C	0	68274	70223	ON	11	PTK1	complement(68274..70223)	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YKL197C	0	70739	73870	ON	11	PEX1	complement(70739..73870)	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
YKL196C	0	74937	75539	ON	11	YKT6	complement(74937..75539)	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
YKL195W	1	75826	77037	ON	11	MIA40	(75826..77037)	Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins
YKL194C	0	77263	78651	ON	11	MST1	complement(77263..78651)	Mitochondrial threonyl-tRNA synthetase
YKL193C	0	78871	79887	ON	11	SDS22	complement(78871..79887)	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
YKL192C	0	80165	80542	ON	11	ACP1	complement(80165..80542)	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YKL191W	1	81040	82644	ON	11	DPH2	(81040..82644)	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YKL190W	1	82952	83555	ON	11	CNB1	(82952..83003,83080..83555)	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YKL189W	1	84709	85908	ON	11	HYM1	(84709..85908)	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YKL188C	0	86230	88791	ON	11	PXA2	complement(86230..88791)	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YKL187C	0	89289	91541	ON	11	YKL187C	complement(89289..91541)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL186C	0	92749	93303	ON	11	MTR2	complement(92749..93303)	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YKL185W	1	94504	96270	ON	11	ASH1	(94504..96270)	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YKL184W	1	96762	98162	ON	11	SPE1	(96762..98162)	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines
YKL183C-A	0	98400	98612	OFF	11	YKL183C-A	complement(98400..98612)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YKL183W	1	98726	99646	ON	11	LOT5	(98726..99646)	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature
YKL182W	1	100676	106831	ON	11	FAS1	(100676..106831)	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YKL181W	1	107321	108604	ON	11	PRS1	(107321..108604)	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, involved in nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YKL180W	1	109274	110134	ON	11	RPL17A	(109274..109582,109889..110134)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YKL179C	0	110469	112508	ON	11	COY1	complement(110469..112508)	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YKL178C	0	113220	114632	ON	11	STE3	complement(113220..114632)	Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YKL177W	1	114361	114699	OFF	11	YKL177W	(114361..114699)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YKL176C	0	115505	117991	ON	11	LST4	complement(115505..117991)	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YKL175W	1	118798	120309	ON	11	ZRT3	(118798..120309)	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
YKL174C	0	120385	122241	ON	11	TPO5	complement(120385..122241)	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
YKL173W	1	122522	125548	ON	11	SNU114	(122522..125548)	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
YKL172W	1	125764	127047	ON	11	EBP2	(125764..127047)	Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
YKL171W	1	127480	130266	ON	11	YKL171W	(127480..130266)	Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YKL170W	1	130639	131055	ON	11	MRPL38	(130639..131055)	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
YKL169C	0	130690	131073	OFF	11	YKL169C	complement(130690..131073)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
YKL168C	0	131293	133467	ON	11	KKQ8	complement(131293..133467)	Putative serine/threonine protein kinase with unknown cellular role
YKL167C	0	133726	134139	ON	11	MRP49	complement(133726..134139)	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YKL166C	0	134514	135710	ON	11	TPK3	complement(134514..135710)	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YKL165C-A	0	135795	136028	OFF	11	YKL165C-A	complement(135795..136028)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL165C	0	137937	140696	ON	11	MCD4	complement(137937..140696)	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YKL164C	0	141799	142824	ON	11	PIR1	complement(141799..142824)	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YKL163W	1	144406	145383	ON	11	PIR3	(144406..145383)	O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL162C-A	0	145927	146079	OFF	11	YKL162C-A	complement(145927..146079)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL162C	0	147635	148843	ON	11	YKL162C	complement(147635..148843)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YKL161C	0	149391	150692	ON	11	YKL161C	complement(149391..150692)	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YKL160W	1	153274	153711	ON	11	ELF1	(153274..153711)	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YKL159C	0	153821	154456	ON	11	RCN1	complement(153821..154456)	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
YKL157W	1	154996	158186	ON	11	APE2	(154996..155276,155660..158186)	Zinc-dependent metallopeptidase yscII, may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W
YKL156W	1	158619	159217	ON	11	RPS27A	(158619..158621,158972..159217)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein
YKL156C-A	0	158980	159096	OFF	11	YKL156C-A	complement(158980..159096)	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL155C	0	159461	161347	ON	11	RSM22	complement(159461..161347)	Mitochondrial ribosomal protein of the small subunit
YKL154W	1	161606	162340	ON	11	SRP102	(161606..162340)	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors Srp101p to the ER membrane
YKL153W	1	163605	164114	OFF	11	YKL153W	(163605..164114)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YKL152C	0	163647	164390	ON	11	GPM1	complement(163647..164390)	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YKL151C	0	164922	165935	ON	11	YKL151C	complement(164922..165935)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL150W	1	166549	167457	ON	11	MCR1	(166549..167457)	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
YKL149C	0	167617	168834	ON	11	DBR1	complement(167617..168834)	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YKL148C	0	169212	171134	ON	11	SDH1	complement(169212..171134)	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL147C	0	171556	172173	OFF	11	YKL147C	complement(171556..172173)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YKL146W	1	171788	173866	ON	11	AVT3	(171788..173866)	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YKL145W	1	174218	175621	ON	11	RPT1	(174218..175621)	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
YKL145W-A	1	174963	175055	OFF	11	YKL145W-A	(174963..175055)	Dubious open reading frame, unlikely to encode a protein; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry
YKL144C	0	175848	176486	ON	11	RPC25	complement(175848..176486)	RNA polymerase III subunit C25
YKL143W	1	176786	178177	ON	11	LTV1	(176786..178177)	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YKL142W	1	178520	179179	ON	11	MRP8	(178520..179179)	Putative mitochondrial ribosomal protein, has similarity to E. coli ribosomal protein S2
YKL141W	1	179672	180268	ON	11	SDH3	(179672..180268)	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YKL140W	1	180784	182430	ON	11	TGL1	(180784..182430)	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YKL139W	1	182963	184549	ON	11	CTK1	(182963..184549)	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YKL138C-A	0	184808	185017	ON	11	HSK3	complement(184808..185017)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YKL138C	0	185291	185686	ON	11	MRPL31	complement(185291..185686)	Mitochondrial ribosomal protein of the large subunit
YKL137W	1	185962	186297	ON	11	YKL137W	(185962..186297)	Putative protein of unknown function; mutation results in growth defect on a non-fermentable (respiratory) carbon source
YKL136W	1	186421	186819	OFF	11	YKL136W	(186421..186819)	Hypothetical protein
YKL135C	0	186465	188645	ON	11	APL2	complement(186465..188645)	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
YKL134C	0	189129	191441	ON	11	OCT1	complement(189129..191441)	Mitochondrial intermediate peptidase, cleaves N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
YKL133C	0	191678	193069	ON	11	YKL133C	complement(191678..193069)	Putative protein of unknown function
YKL132C	0	193573	194865	ON	11	RMA1	complement(193573..194865)	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL131W	1	194477	194998	OFF	11	YKL131W	(194477..194998)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL130C	0	195287	196027	ON	11	SHE2	complement(195287..196027)	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
YKL129C	0	196348	200163	ON	11	MYO3	complement(196348..200163)	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
YKL128C	0	200528	201415	ON	11	PMU1	complement(200528..201415)	Putative phosphomutase, contains a region homologous to the active site of phsophomutases; overexpression of the gene suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YKL127W	1	203185	204897	ON	11	PGM1	(203185..204897)	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YKL126W	1	205351	207393	ON	11	YPK1	(205351..207393)	Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK
YKL125W	1	207891	209774	ON	11	RRN3	(207891..209774)	Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
YKL124W	1	210237	211976	ON	11	SSH4	(210237..211976)	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane
YKL123W	1	211687	212067	OFF	11	YKL123W	(211687..212067)	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
YKL122C	0	212139	212642	ON	11	SRP21	complement(212139..212642)	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YKL121W	1	213786	216344	ON	11	YKL121W	(213786..216344)	Putative protein of unknown function
YKL120W	1	216988	217962	ON	11	OAC1	(216988..217962)	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YKL119C	0	218214	218861	ON	11	VPH2	complement(218214..218861)	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YKL118W	1	218770	219081	OFF	11	YKL118W	(218770..219081)	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YKL117W	1	219968	220618	ON	11	SBA1	(219968..220618)	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YKL116C	0	220988	222544	ON	11	PRR1	complement(220988..222544)	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YKL115C	0	222537	222929	OFF	11	YKL115C	complement(222537..222929)	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
YKL114C	0	222996	224099	ON	11	APN1	complement(222996..224099)	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YKL113C	0	224371	225519	ON	11	RAD27	complement(224371..225519)	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YKL112W	1	226214	228409	ON	11	ABF1	(226214..228409)	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YKL111C	0	228108	228443	OFF	11	YKL111C	complement(228108..228443)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1
YKL110C	0	228583	229524	ON	11	KTI12	complement(228583..229524)	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKL109W	1	231871	233535	ON	11	HAP4	(231871..233535)	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YKL108W	1	234070	235431	ON	11	SLD2	(234070..235431)	Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate
YKL107W	1	235785	236714	ON	11	YKL107W	(235785..236714)	Putative protein of unknown function
YKL106C-A	0	236791	236910	OFF	11	YKL106C-A	complement(236791..236910)	Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
YKL106W	1	237180	238535	ON	11	AAT1	(237180..238535)	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YKL105C	0	238829	242227	ON	11	YKL105C	complement(238829..242227)	Putative protein of unknown function
YKL104C	0	242864	245017	ON	11	GFA1	complement(242864..245017)	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
YKL103C	0	245782	247326	ON	11	LAP4	complement(245782..247326)	Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YKL102C	0	247706	248011	OFF	11	YKL102C	complement(247706..248011)	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YKL101W	1	248564	253120	ON	11	HSL1	(248564..253120)	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YKL100C	0	253341	255104	ON	11	YKL100C	complement(253341..255104)	Putative protein of unknown function with similarity to a human minor histocompatibility antigen; YKL100C is not an essential gene
YKL100W-A	1	253803	253892	OFF	11	YKL100W-A	(253803..253892)	Putative protein of unknown function; identified by expression profiling and mass spectrometry
YKL099C	0	255364	256116	ON	11	UTP11	complement(255364..256116)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YKL098W	1	256414	257487	ON	11	YKL098W	(256414..257487)	Putative protein of unknown function
YKL097C	0	258147	258557	OFF	11	YKL097C	complement(258147..258557)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species
YKL096C-B	0	258717	258866	OFF	11	YKL096C-B	complement(258717..258866)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL096W-A	1	258897	259175	ON	11	CWP2	(258897..259175)	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YKL096W	1	260776	261495	ON	11	CWP1	(260776..261495)	Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YKL095W	1	261921	262757	ON	11	YJU2	(261921..262757)	Essential nuclear protein; putative spliceosomal component involved in mRNA splicing, based on computational analysis of large-scale protein-protein interaction data
YKL094W	1	262993	263934	ON	11	YJU3	(262993..263934)	Serine hydrolase with sequence similarity to monoglyceride lipase (MGL), localizes to lipid particles
YKL093W	1	264433	265452	ON	11	MBR1	(264433..265452)	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YKL092C	0	265789	269103	ON	11	BUD2	complement(265789..269103)	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
YKL091C	0	269362	270294	ON	11	YKL091C	complement(269362..270294)	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YKL090W	1	271522	272853	ON	11	CUE2	(271522..272853)	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YKL089W	1	273038	274687	ON	11	MIF2	(273038..274687)	Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p
YKL088W	1	274927	276642	ON	11	YKL088W	(274927..276642)	Predicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p
YKL087C	0	276833	277507	ON	11	CYT2	complement(276833..277507)	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YKL086W	1	277925	278308	ON	11	SRX1	(277925..278308)	Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YKL085W	1	278767	279771	ON	11	MDH1	(278767..279771)	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle
YKL084W	1	280153	280503	ON	11	HOT13	(280153..280503)	Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex
YKL083W	1	280565	281179	OFF	11	YKL083W	(280565..281179)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene RRP14
YKL082C	0	280669	281973	ON	11	RRP14	complement(280669..281973)	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
YKL081W	1	282535	284099	ON	11	TEF4	(282535..282739,283066..284099)	Translation elongation factor EF-1 gamma
YKL080W	1	284674	285852	ON	11	VMA5	(284674..285852)	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YKL079W	1	286247	288217	ON	11	SMY1	(286247..288217)	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
YKL078W	1	288489	290696	ON	11	DHR2	(288489..290696)	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YKL077W	1	291097	292275	ON	11	YKL077W	(291097..292275)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YKL076C	0	292482	292865	OFF	11	PSY1	complement(292482..292865)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
YKL075C	0	292600	293952	ON	11	YKL075C	complement(292600..293952)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
YKL074C	0	294254	295837	ON	11	MUD2	complement(294254..295837)	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
YKL073W	1	296074	298719	ON	11	LHS1	(296074..298719)	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; member of the Hsp70 family; localizes to the lumen of the ER; regulated by the unfolded protein response pathway
YKL072W	1	299226	301526	ON	11	STB6	(299226..301526)	Protein that binds Sin3p in a two-hybrid assay
YKL071W	1	304758	305528	ON	11	YKL071W	(304758..305528)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL070W	1	305855	306364	ON	11	YKL070W	(305855..306364)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL069W	1	306929	307471	ON	11	YKL069W	(306929..307471)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKL068W-A	1	308850	309086	ON	11	YKL068W-A	(308850..309086)	Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>
YKL068W	1	309843	312722	ON	11	NUP100	(309843..312722)	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YKL067W	1	314456	314917	ON	11	YNK1	(314456..314917)	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
YKL066W	1	314925	315368	OFF	11	YKL066W	(314925..315368)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1
YKL065W-A	1	315598	315819	ON	11	YKL065W-A	(315598..315819)	Putative protein of unknown function
YKL065C	0	316081	316701	ON	11	YET1	complement(316081..316701)	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YKL064W	1	317408	320317	ON	11	MNR2	(317408..320317)	Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
YKL063C	0	320659	321162	ON	11	YKL063C	complement(320659..321162)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YKL062W	1	322872	324764	ON	11	MSN4	(322872..324764)	Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YKL061W	1	325415	325756	ON	11	YKL061W	(325415..325756)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome
YKL060C	0	326052	327131	ON	11	FBA1	complement(326052..327131)	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YKL059C	0	327762	329087	ON	11	MPE1	complement(327762..329087)	Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YKL058W	1	329810	330178	ON	11	TOA2	(329810..330178)	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA
YKL057C	0	330500	333613	ON	11	NUP120	complement(330500..333613)	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YKL056C	0	334056	334559	ON	11	TMA19	complement(334056..334559)	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YKL055C	0	334965	335801	ON	11	OAR1	complement(334965..335801)	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
YKL054C	0	336181	338397	ON	11	DEF1	complement(336181..338397)	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex
YKL053C-A	0	338826	339086	ON	11	MDM35	complement(338826..339086)	Mitochondrial intermembrane space cysteine motif protein; mutation affects mitochondrial distribution and morphology
YKL053W	1	339216	339590	OFF	11	YKL053W	(339216..339590)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
YKL052C	0	339312	340190	ON	11	ASK1	complement(339312..340190)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YKL051W	1	340956	342017	ON	11	SFK1	(340956..342017)	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YKL050C	0	342496	345264	ON	11	YKL050C	complement(342496..345264)	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YKL049C	0	345719	346408	ON	11	CSE4	complement(345719..346408)	Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A
YKL048C	0	346858	348780	ON	11	ELM1	complement(346858..348780)	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
YKL047W	1	349107	350657	ON	11	YKL047W	(349107..350657)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL046C	0	350919	352268	ON	11	DCW1	complement(350919..352268)	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YKL045W	1	353137	354723	ON	11	PRI2	(353137..354723)	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YKL044W	1	355966	356286	OFF	11	YKL044W	(355966..356286)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL043W	1	356392	357492	ON	11	PHD1	(356392..357492)	Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YKL042W	1	358119	359210	ON	11	SPC42	(358119..359210)	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YKL041W	1	359786	360460	ON	11	VPS24	(359786..360460)	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
YKL040C	0	360701	361471	ON	11	NFU1	complement(360701..361471)	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YKL039W	1	362265	363836	ON	11	PTM1	(362265..363836)	Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
YKL038W	1	365248	368760	ON	11	RGT1	(365248..368760)	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YKL037W	1	369008	369364	OFF	11	YKL037W	(369008..369364)	Putative protein of unknown function
YKL036C	0	369171	369563	OFF	11	YKL036C	complement(369171..369563)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
YKL035W	1	369534	371033	ON	11	UGP1	(369534..371033)	UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p
YKL034W	1	371472	373748	ON	11	TUL1	(371472..373748)	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
YKL033W-A	1	374148	374858	ON	11	YKL033W-A	(374148..374858)	Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YKL033W	1	375099	378215	ON	11	YKL033W	(375099..378215)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YKL033W is an essential gene
YKL032C	0	379708	381501	ON	11	IXR1	complement(379708..381501)	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YKL031W	1	381715	382128	OFF	11	YKL031W	(381715..382128)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YKL030W	1	382141	382746	OFF	11	YKL030W	(382141..382746)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1
YKL029C	0	382359	384368	ON	11	MAE1	complement(382359..384368)	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YKL028W	1	385401	386849	ON	11	TFA1	(385401..386849)	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YKL027W	1	387205	388548	ON	11	YKL027W	(387205..388548)	Protein of unknown function, localized to the mitochondrial outer membrane
YKL026C	0	389023	389526	ON	11	GPX1	complement(389023..389526)	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YKL025C	0	389883	391922	ON	11	PAN3	complement(389883..391922)	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
YKL024C	0	392169	392783	ON	11	URA6	complement(392169..392783)	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
YKL023C-A	0	392789	393016	OFF	11	YKL023C-A	complement(392789..393016)	Putative protein of unknown function
YKL023W	1	393364	394197	ON	11	YKL023W	(393364..394197)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL022C	0	394369	396891	ON	11	CDC16	complement(394369..396891)	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
YKL021C	0	396987	398393	ON	11	MAK11	complement(396987..398393)	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YKL020C	0	398475	401723	ON	11	SPT23	complement(398475..401723)	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YKL019W	1	402211	403161	ON	11	RAM2	(402211..403161)	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
YKL018C-A	0	403223	403522	ON	11	YKL018C-A	complement(403223..403522)	Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL018W	1	403745	404734	ON	11	SWD2	(403745..404734)	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
YKL017C	0	404833	406884	ON	11	HCS1	complement(404833..406884)	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
YKL016C	0	407108	407632	ON	11	ATP7	complement(407108..407632)	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YKL015W	1	408187	411126	ON	11	PUT3	(408187..411126)	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YKL014C	0	411262	416556	ON	11	URB1	complement(411262..416556)	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YKL013C	0	417151	417666	ON	11	ARC19	complement(417151..417666)	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YKL012W	1	417953	419704	ON	11	PRP40	(417953..419704)	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YKL011C	0	419798	420859	ON	11	CCE1	complement(419798..420859)	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA
YKL010C	0	421067	425518	ON	11	UFD4	complement(421067..425518)	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
YKL009W	1	425885	426595	ON	11	MRT4	(425885..426595)	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YKL008C	0	426938	428194	ON	11	LAC1	complement(426938..428194)	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YKL007W	1	428945	429751	ON	11	CAP1	(428945..429751)	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YKL006C-A	0	429841	430275	ON	11	SFT1	complement(429841..430098,430240..430275)	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
YKL006W	1	431549	432363	ON	11	RPL14A	(431549..431677,432076..432363)	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth
YKL005C	0	432736	434520	ON	11	BYE1	complement(432736..434520)	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
YKL004W	1	435223	436428	ON	11	AUR1	(435223..436428)	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YKL003C	0	436740	437135	ON	11	MRP17	complement(436740..437135)	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
YKL002W	1	437421	438187	ON	11	DID4	(437421..437480,437549..438187)	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YKL001C	0	438420	439028	ON	11	MET14	complement(438420..439028)	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YKR001C	0	440251	442365	ON	11	VPS1	complement(440251..442365)	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YKR002W	1	442875	444581	ON	11	PAP1	(442875..444581)	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs
YKR003W	1	445024	446370	ON	11	OSH6	(445024..446370)	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YKR004C	0	446442	447679	ON	11	ECM9	complement(446442..447349,447454..447679)	Non-essential protein of unknown function
YKR005C	0	448164	449507	ON	11	YKR005C	complement(448164..449507)	Putative protein of unknown function
YKR006C	0	450066	450860	ON	11	MRPL13	complement(450066..450860)	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
YKR007W	1	451077	451631	ON	11	MEH1	(451077..451631)	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
YKR008W	1	451844	453721	ON	11	RSC4	(451844..453721)	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling
YKR009C	0	453995	456697	ON	11	FOX2	complement(453995..456697)	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YKR010C	0	458567	460882	ON	11	TOF2	complement(458567..460882)	Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
YKR011C	0	461278	462339	ON	11	YKR011C	complement(461278..462339)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YKR012C	0	463382	463759	OFF	11	YKR012C	complement(463382..463759)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YKR013W	1	463602	464591	ON	11	PRY2	(463602..464591)	Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YKR014C	0	465010	465714	ON	11	YPT52	complement(465010..465714)	GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YKR015C	0	466604	468310	ON	11	YKR015C	complement(466604..468310)	Putative protein of unknown function
YKR016W	1	469360	470982	ON	11	YKR016W	(469360..470982)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR017C	0	471337	472992	ON	11	YKR017C	complement(471337..472992)	Putative protein of unknown function; contains a RING finger motif
YKR018C	0	473366	475543	ON	11	YKR018C	complement(473366..475543)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR019C	0	475859	477706	ON	11	IRS4	complement(475859..477706)	Protein involved in regulation of phosphatidylinositol 4,5-bisphosphate concentrations; Irs4p and Tax4p bind and activate the phosphatase Inp51p; mutation confers an increase in rDNA silencing
YKR020W	1	477981	478475	ON	11	VPS51	(477981..478475)	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP)  complex to the SNARE Tlg1p
YKR021W	1	478877	481624	ON	11	YKR021W	(478877..481624)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKR022C	0	481814	482782	ON	11	NTR2	complement(481814..482782)	Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YKR023W	1	483062	484654	ON	11	YKR023W	(483062..484654)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR024C	0	484787	487015	ON	11	DBP7	complement(484787..487015)	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YKR025W	1	487413	488261	ON	11	RPC37	(487413..488261)	RNA polymerase III subunit C37
YKR026C	0	488381	489298	ON	11	GCN3	complement(488381..489298)	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YKR027W	1	491007	493304	ON	11	BCH2	(491007..493304)	Member of the Chs5p-Arf1p-binding proteins (ChAPs), a group of 4 related, interacting proteins (Bch1p, Fmp50p, Bud7p, Chs6p) that mediate export of specific cargo proteins, including chitin synthase Chs3p, from the Golgi to plasma membrane
YKR028W	1	493900	497196	ON	11	SAP190	(493900..497196)	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
YKR029C	0	497220	499475	ON	11	SET3	complement(497220..499475)	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains
YKR030W	1	499924	500745	ON	11	GMH1	(499924..500745)	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YKR031C	0	500986	506037	ON	11	SPO14	complement(500986..506037)	Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YKR032W	1	506159	506473	OFF	11	YKR032W	(506159..506473)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR033C	0	506521	506946	OFF	11	YKR033C	complement(506521..506946)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YKR034W	1	506540	507349	ON	11	DAL80	(506540..507349)	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YKR035C	0	507562	508203	OFF	11	OPI8	complement(507562..508203)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
YKR035W-A	1	507581	508195	ON	11	DID2	(507581..508195)	Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors
YKR036C	0	508344	510275	ON	11	CAF4	complement(508344..510275)	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YKR037C	0	510552	511439	ON	11	SPC34	complement(510552..511439)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YKR038C	0	511641	512801	ON	11	KAE1	complement(511641..512801)	Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YKR039W	1	514705	516513	ON	11	GAP1	(514705..516513)	General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YKR040C	0	517705	518208	OFF	11	YKR040C	complement(517705..518208)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YKR041W	1	517840	518592	ON	11	YKR041W	(517840..518592)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR042W	1	519169	520266	ON	11	UTH1	(519169..520266)	Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YKR043C	0	520539	521354	ON	11	YKR043C	complement(520539..521354)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YKR044W	1	521657	522988	ON	11	UIP5	(521657..522988)	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
YKR045C	0	523060	523611	ON	11	YKR045C	complement(523060..523611)	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YKR046C	0	523865	524716	ON	11	PET10	complement(523865..524716)	Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YKR047W	1	524899	525204	OFF	11	YKR047W	(524899..525204)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1
YKR048C	0	525029	526282	ON	11	NAP1	complement(525029..526282)	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus
YKR049C	0	526472	526873	ON	11	FMP46	complement(526472..526873)	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR050W	1	527457	530126	ON	11	TRK2	(527457..530126)	Component of the Trk1p-Trk2p potassium transport system
YKR051W	1	530588	531844	ON	11	YKR051W	(530588..531844)	Putative protein of unknown function
YKR052C	0	532192	533106	ON	11	MRS4	complement(532192..533106)	Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YKR053C	0	533709	534923	ON	11	YSR3	complement(533709..534923)	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p
YKR054C	0	535289	547567	ON	11	DYN1	complement(535289..547567)	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
YKR055W	1	547858	548733	ON	11	RHO4	(547858..548733)	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YKR056W	1	549090	551009	ON	11	TRM2	(549090..551009)	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YKR057W	1	551299	551884	ON	11	RPS21A	(551299..551322,551645..551884)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
YKR058W	1	552412	554262	ON	11	GLG1	(552412..554262)	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
YKR059W	1	554629	555816	ON	11	TIF1	(554629..555816)	Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YKR060W	1	556160	556984	ON	11	UTP30	(556160..556984)	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YKR061W	1	557319	558596	ON	11	KTR2	(557319..558596)	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YKR062W	1	559308	560294	ON	11	TFA2	(559308..560294)	TFIIE small subunit, involved in RNA polymerase II transcription initiation
YKR063C	0	560431	561939	ON	11	LAS1	complement(560431..561939)	Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability
YKR064W	1	562189	564780	ON	11	YKR064W	(562189..564780)	Zinc cluster protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR065C	0	564941	565534	ON	11	PAM17	complement(564941..565534)	Presequence translocase-associated motor subunit, required for stable complex formation between cochaperones Pam16p and Pam18p, promotes association of Pam16p-Pam18p with the presequence translocase
YKR066C	0	565755	566840	ON	11	CCP1	complement(565755..566840)	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YKR067W	1	567560	569791	ON	11	GPT2	(567560..569791)	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YKR068C	0	569970	570551	ON	11	BET3	complement(569970..570551)	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
YKR069W	1	571254	573035	ON	11	MET1	(571254..573035)	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YKR070W	1	573216	574274	ON	11	YKR070W	(573216..574274)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR071C	0	574576	575622	ON	11	DRE2	complement(574576..575622)	Protein of unknown function; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2
YKR072C	0	576077	577765	ON	11	SIS2	complement(576077..577765)	Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YKR073C	0	577829	578149	OFF	11	YKR073C	complement(577829..578149)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR074W	1	578851	579318	ON	11	YKR074W	(578851..579318)	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YKR075C	0	579469	580392	ON	11	YKR075C	complement(579469..580392)	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YKR075W-A	1	579854	580123	OFF	11	YKR075W-A	(579854..580123)	Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKR076W	1	581925	583037	ON	11	ECM4	(581925..583037)	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKR077W	1	583295	584386	ON	11	YKR077W	(583295..584386)	Putative transcriptional activator, identified by high-throughput two-hybrid experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YKR077W is not an essential gene
YKR078W	1	584594	586351	ON	11	YKR078W	(584594..586351)	Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
YKR079C	0	586431	588947	ON	11	TRZ1	complement(586431..588947)	tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YKR080W	1	590037	590999	ON	11	MTD1	(590037..590999)	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YKR081C	0	591148	592182	ON	11	RPF2	complement(591148..592182)	Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YKR082W	1	592467	595940	ON	11	NUP133	(592467..595940)	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
YKR083C	0	596063	596464	ON	11	DAD2	complement(596063..596464)	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YKR084C	0	596697	598532	ON	11	HBS1	complement(596697..598532)	GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components
YKR085C	0	598736	599323	ON	11	MRPL20	complement(598736..599323)	Mitochondrial ribosomal protein of the large subunit
YKR086W	1	599499	602714	ON	11	PRP16	(599499..602714)	RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity
YKR087C	0	602837	603874	ON	11	OMA1	complement(602837..603874)	Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
YKR088C	0	604047	605060	ON	11	TVP38	complement(604047..605060)	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKR089C	0	605275	608007	ON	11	TGL4	complement(605275..608007)	Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate
YKR090W	1	608588	610708	ON	11	PXL1	(608588..610708)	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YKR091W	1	611167	611907	ON	11	SRL3	(611167..611907)	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
YKR092C	0	612307	613527	ON	11	SRP40	complement(612307..613527)	Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YKR093W	1	615372	617177	ON	11	PTR2	(615372..617177)	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YKR094C	0	617638	618392	ON	11	RPL40B	complement(617638..618016,618385..618392)	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YKR095W	1	619447	625074	ON	11	MLP1	(619447..625074)	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YKR095W-A	1	625506	625847	ON	11	PCC1	(625506..625543,625619..625847)	Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens
YKR096W	1	626435	630022	ON	11	YKR096W	(626435..630022)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YKR097W	1	630790	632439	ON	11	PCK1	(630790..632439)	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YKR098C	0	632664	634817	ON	11	UBP11	complement(632664..634817)	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
YKR099W	1	635489	637924	ON	11	BAS1	(635489..637924)	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YKR100C	0	638539	639606	ON	11	SKG1	complement(638539..639606)	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YKR101W	1	640106	642142	ON	11	SIR1	(640106..642142)	Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YKR102W	1	645994	649503	ON	11	FLO10	(645994..649503)	Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YKR103W	1	652718	656374	ON	11	NFT1	(652718..656374)	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YKR104W	1	656474	657394	ON	11	YKR104W	(656474..657394)	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YKR105C	0	658354	660102	ON	11	YKR105C	complement(658354..660102)	Putative transporter of the Major Facilitator Superfamily (MFS)
YKR106W	1	661080	662927	ON	11	YKR106W	(661080..662927)	Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YCL073C
YLL067C	0	585	4301	ON	12	YLL067C	complement(585..3915,4015..4301)	Putative protein of unknown function with similarity to helicases
YLL067W-A	1	843	1325	OFF	12	YLL067W-A	(843..1325)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YLL067C
YLL066W-B	1	5605	5775	OFF	12	YLL066W-B	(5605..5775)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL066C	0	6120	9836	ON	12	YLL066C	complement(6120..9450,9550..9836)	Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene
YLL066W-A	1	6486	6968	OFF	12	YLL066W-A	(6486..6968)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C
YLL065W	1	11726	12076	OFF	12	YLL065W	(11726..12076)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences
YLL064C	0	13083	13445	ON	12	YLL064C	complement(13083..13445)	Hypothetical protein
YLL063C	0	14648	16072	ON	12	AYT1	complement(14648..16072)	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YLL062C	0	16639	17613	ON	12	MHT1	complement(16639..17613)	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YLL061W	1	17956	19707	ON	12	MMP1	(17956..19707)	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YLL060C	0	21138	21839	ON	12	GTT2	complement(21138..21839)	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YLL059C	0	22474	22980	OFF	12	YLL059C	complement(22474..22980)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL058W	1	23569	25296	ON	12	YLL058W	(23569..25296)	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
YLL057C	0	25756	26994	ON	12	JLP1	complement(25756..26994)	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YLL056C	0	27409	28305	ON	12	YLL056C	complement(27409..28305)	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLL055W	1	30109	31704	ON	12	YCT1	(30109..31704)	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YLL054C	0	32894	35203	ON	12	YLL054C	complement(32894..35203)	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
YLL053C	0	35502	35960	OFF	12	YLL053C	complement(35502..35960)	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLL052C	0	35911	36360	ON	12	AQY2	complement(35911..36360)	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YLL051C	0	37332	39470	ON	12	FRE6	complement(37332..39470)	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
YLL050C	0	39803	40413	ON	12	COF1	complement(39803..40220,40400..40413)	Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes
YLL049W	1	40665	41204	ON	12	LDB18	(40665..41204)	Protein of unknown function; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YLL048C	0	41279	46264	ON	12	YBT1	complement(41279..46264)	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters
YLL047W	1	46671	47054	OFF	12	YLL047W	(46671..47054)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
YLL046C	0	46713	47462	ON	12	RNP1	complement(46713..47462)	Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YLL045C	0	47858	48628	ON	12	RPL8B	complement(47858..48628)	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YLL044W	1	48215	48661	OFF	12	YLL044W	(48215..48661)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YLL043W	1	49937	51946	ON	12	FPS1	(49937..51946)	Plasma membrane glycerol channel, member of the major intrinsic protein (MIP) family of channel proteins; involved in efflux of glycerol and in uptake of the trivalent metalloids arsenite and antimonite
YLL042C	0	52086	52589	ON	12	ATG10	complement(52086..52589)	E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
YLL041C	0	53130	53930	ON	12	SDH2	complement(53130..53930)	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLL040C	0	54210	63644	ON	12	VPS13	complement(54210..63644)	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
YLL039C	0	64061	65206	ON	12	UBI4	complement(64061..65206)	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YLL038C	0	65774	66517	ON	12	ENT4	complement(65774..66517)	Protein of unknown function, contains an N-terminal epsin-like domain
YLL037W	1	66561	66941	OFF	12	YLL037W	(66561..66941)	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
YLL036C	0	66744	68255	ON	12	PRP19	complement(66744..68255)	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
YLL035W	1	68579	70477	ON	12	GRC3	(68579..70477)	Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated
YLL034C	0	70632	73145	ON	12	RIX7	complement(70632..73145)	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YLL033W	1	73408	74100	ON	12	YLL033W	(73408..74100)	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52 foci
YLL032C	0	74269	76746	ON	12	YLL032C	complement(74269..76746)	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
YLL031C	0	77151	80204	ON	12	GPI13	complement(77151..80204)	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YLL030C	0	80355	80696	OFF	12	YLL030C	complement(80355..80696)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL029W	1	81460	83709	ON	12	YLL029W	(81460..83709)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL029W is not an essential gene but mutant is defective in spore formation
YLL028W	1	84803	86563	ON	12	TPO1	(84803..86563)	Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YLL027W	1	87402	88154	ON	12	ISA1	(87402..88154)	Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YLL026W	1	88622	91348	ON	12	HSP104	(88622..91348)	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
YLL025W	1	94746	95120	ON	12	YLL025W	(94746..95120)	Putative protein of unknown function; YLL025W is not an essential gene
YLL024C	0	95565	97484	ON	12	SSA2	complement(95565..97484)	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YLL023C	0	97996	98835	ON	12	YLL023C	complement(97996..98835)	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YLL022C	0	99043	100200	ON	12	HIF1	complement(99043..100200)	Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YLL021W	1	100946	105346	ON	12	SPA2	(100946..105346)	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YLL020C	0	105555	105860	OFF	12	YLL020C	complement(105555..105860)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1
YLL019C	0	105685	107898	ON	12	KNS1	complement(105685..107898)	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YLL019W-A	1	106907	106999	OFF	12	YLL019W-A	(106907..106999)	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene KNS1
YLL018C-A	0	108675	108971	ON	12	COX19	complement(108675..108971)	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YLL018C	0	109901	111574	ON	12	DPS1	complement(109901..111574)	Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YLL017W	1	112233	112544	OFF	12	YLL017W	(112233..112544)	Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL016W
YLL016W	1	112846	115992	ON	12	SDC25	(112846..115992)	Non-essential Ras guanine nucleotide exchange factor (GEF) localized to the membrane; expressed in poor nutrients and on non-fermentable carbon sources; homologous to CDC25; contains a stop codon in S288C; full-length gene includes YLL017W
YLL015W	1	116431	121110	ON	12	BPT1	(116431..121110)	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
YLL014W	1	121321	121647	ON	12	YLL014W	(121321..121647)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLL014W is not an essential gene
YLL013C	0	122074	124713	ON	12	PUF3	complement(122074..124713)	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YLL012W	1	125533	127254	ON	12	YEH1	(125533..127254)	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YLL011W	1	127522	128991	ON	12	SOF1	(127522..128991)	Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YLL010C	0	129329	130612	ON	12	PSR1	complement(129329..130612)	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YLL009C	0	131204	131413	ON	12	COX17	complement(131204..131413)	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase
YLL008W	1	131728	133986	ON	12	DRS1	(131728..133986)	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YLL007C	0	134301	136298	ON	12	YLL007C	complement(134301..136298)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene
YLL006W-A	1	136344	136520	OFF	12	YLL006W-A	(136344..136520)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YLL006W	1	136585	137865	ON	12	MMM1	(136585..137865)	Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins
YLL005C	0	137939	140545	ON	12	SPO75	complement(137939..140545)	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YLL004W	1	141072	142922	ON	12	ORC3	(141072..142922)	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YLL003W	1	143200	146040	ON	12	SFI1	(143200..146040)	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
YLL002W	1	146290	147600	ON	12	RTT109	(146290..147600)	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
YLL001W	1	147889	150162	ON	12	DNM1	(147889..150162)	Dynamin-related GTPase required for mitochondrial fission and the maintenance of mitochondrial morphology, assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis
YLR001C	0	151388	153976	ON	12	YLR001C	complement(151388..153976)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR001C is not an essential gene
YLR002C	0	154342	156333	ON	12	NOC3	complement(154342..156333)	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YLR003C	0	156854	157729	ON	12	YLR003C	complement(156854..157729)	Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene
YLR004C	0	157933	159504	ON	12	THI73	complement(157933..159504)	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YLR005W	1	160048	161433	ON	12	SSL1	(160048..161433)	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
YLR006C	0	161754	163892	ON	12	SSK1	complement(161754..163892)	Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YLR007W	1	164391	165401	ON	12	NSE1	(164391..165401)	Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth
YLR008C	0	165576	166082	ON	12	PAM18	complement(165576..166082)	J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p
YLR009W	1	166536	167135	ON	12	RLP24	(166536..167135)	Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YLR010C	0	167319	167801	ON	12	TEN1	complement(167319..167801)	Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YLR011W	1	169102	169677	ON	12	LOT6	(169102..169677)	FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YLR012C	0	169981	170280	ON	12	YLR012C	complement(169981..170280)	Putative protein of unknown function; YLR012C is not an essential gene
YLR013W	1	171338	171763	ON	12	GAT3	(171338..171763)	Protein containing GATA family zinc finger motifs
YLR014C	0	172267	174981	ON	12	PPR1	complement(172267..174981)	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p
YLR015W	1	175226	176743	ON	12	BRE2	(175226..176743)	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
YLR016C	0	176801	177415	ON	12	PML1	complement(176801..177415)	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
YLR017W	1	177607	178620	ON	12	MEU1	(177607..178620)	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YLR018C	0	178706	179605	ON	12	POM34	complement(178706..179605)	Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
YLR019W	1	180287	181480	ON	12	PSR2	(180287..181480)	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YLR020C	0	181788	183404	ON	12	YEH2	complement(181788..183404)	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
YLR021W	1	183622	184161	ON	12	YLR021W	(183622..184161)	Putative protein of unknown function; mutant accumulates unusually high amounts of dityrosine in the soluble fraction though spores appear wild-type; YLR021W is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci
YLR022C	0	184173	184925	ON	12	SDO1	complement(184173..184925)	Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
YLR023C	0	185497	187128	ON	12	IZH3	complement(185497..187128)	Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YLR024C	0	187664	193282	ON	12	UBR2	complement(187664..193282)	Cytoplasmic ubiquitin-protein ligase (E3)
YLR025W	1	194453	195175	ON	12	SNF7	(194453..195175)	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YLR026C	0	195451	196473	ON	12	SED5	complement(195451..196473)	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YLR027C	0	196830	198086	ON	12	AAT2	complement(196830..198086)	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YLR028C	0	199541	201316	ON	12	ADE16	complement(199541..201316)	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YLR029C	0	201977	202591	ON	12	RPL15A	complement(201977..202591)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YLR030W	1	203291	204082	OFF	12	YLR030W	(203291..204082)	Putative protein of unknown function
YLR031W	1	204226	204786	ON	12	YLR031W	(204226..204786)	Putative protein of unknown function
YLR032W	1	204992	208501	ON	12	RAD5	(204992..208501)	Single-stranded DNA-dependent ATPase, involved in postreplication repair; contains RING finger domain
YLR033W	1	208762	210270	ON	12	RSC58	(208762..210270)	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance58KDa subunit
YLR034C	0	210513	211934	ON	12	SMF3	complement(210513..211934)	Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins
YLR035C	0	212370	214457	ON	12	MLH2	complement(212370..214457)	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
YLR036C	0	221522	222133	ON	12	YLR036C	complement(221522..222133)	Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
YLR037C	0	222686	223060	ON	12	DAN2	complement(222686..223060)	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR038C	0	224922	225173	ON	12	COX12	complement(224922..225173)	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly
YLR039C	0	225427	228597	ON	12	RIC1	complement(225427..228597)	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YLR040C	0	228909	229583	ON	12	YLR040C	complement(228909..229583)	Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential
YLR041W	1	229378	229698	OFF	12	YLR041W	(229378..229698)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
YLR042C	0	229967	230452	ON	12	YLR042C	complement(229967..230452)	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YLR043C	0	231703	232014	ON	12	TRX1	complement(231703..232014)	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
YLR044C	0	232391	234082	ON	12	PDC1	complement(232391..234082)	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YLR045C	0	235038	237704	ON	12	STU2	complement(235038..237704)	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
YLR046C	0	238002	238814	ON	12	YLR046C	complement(238002..238814)	Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YLR047C	0	239348	241408	ON	12	FRE8	complement(239348..241408)	Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YLR048W	1	242233	243350	ON	12	RPS0B	(242233..242322,242682..243350)	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR049C	0	243887	245173	ON	12	YLR049C	complement(243887..245173)	Putative protein of unknown function
YLR050C	0	245588	246073	ON	12	YLR050C	complement(245588..246073)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
YLR051C	0	246325	246978	ON	12	FCF2	complement(246325..246978)	Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YLR052W	1	247202	247954	ON	12	IES3	(247202..247954)	Subunit of the INO80 chromatin remodeling complex
YLR053C	0	248101	248427	ON	12	YLR053C	complement(248101..248427)	Putative protein of unknown function
YLR054C	0	248718	250979	ON	12	OSW2	complement(248718..250861,250949..250979)	Protein of unknown function proposed to be involved in the assembly of the spore wall
YLR055C	0	251273	253081	ON	12	SPT8	complement(251273..253081)	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YLR056W	1	253862	254959	ON	12	ERG3	(253862..254959)	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YLR057W	1	255307	257856	ON	12	YLR057W	(255307..257856)	Putative protein of unknown function; YLR050C is not an essential gene
YLR058C	0	257993	259402	ON	12	SHM2	complement(257993..259402)	Cytosolic serine hydroxymethyltransferase, involved in one-carbon metabolism
YLR059C	0	259739	260548	ON	12	REX2	complement(259739..260548)	RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YLR060W	1	260980	262767	ON	12	FRS1	(260980..262767)	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar
YLR061W	1	263195	263949	ON	12	RPL22A	(263195..263206,263596..263949)	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YLR062C	0	263578	263955	OFF	12	BUD28	complement(263578..263955)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YLR063W	1	264158	265255	ON	12	YLR063W	(264158..265255)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YLR064W	1	265457	266278	ON	12	YLR064W	(265457..266278)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene
YLR065C	0	266374	266919	ON	12	YLR065C	complement(266374..266919)	Putative protein of unknown function; YLR065C is not an essential gene
YLR066W	1	267170	267724	ON	12	SPC3	(267170..267724)	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YLR067C	0	267814	270711	ON	12	PET309	complement(267814..270711)	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane
YLR068W	1	271009	271464	ON	12	FYV7	(271009..271464)	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YLR069C	0	271631	273916	ON	12	MEF1	complement(271631..273916)	Mitochondrial elongation factor involved in translational elongation
YLR070C	0	274142	275212	ON	12	XYL2	complement(274142..275212)	Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway
YLR071C	0	275379	278627	ON	12	RGR1	complement(275379..278627)	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
YLR072W	1	278863	280944	ON	12	YLR072W	(278863..280944)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene
YLR073C	0	281020	281622	ON	12	YLR073C	complement(281020..281622)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes; YLR073C is not an esssential gene
YLR074C	0	281957	282457	ON	12	BUD20	complement(281957..282457)	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YLR075W	1	282928	283593	ON	12	RPL10	(282928..283593)	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YLR076C	0	283186	283608	OFF	12	YLR076C	complement(283186..283608)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
YLR077W	1	283873	285624	ON	12	YLR077W	(283873..285624)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR078C	0	285737	286560	ON	12	BOS1	complement(285737..286468,286558..286560)	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YLR079W	1	286821	287675	ON	12	SIC1	(286821..287675)	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
YLR080W	1	287917	289251	ON	12	EMP46	(287917..289251)	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YLR081W	1	290213	291937	ON	12	GAL2	(290213..291937)	Galactose permease, required for utilization of galactose; also able to transport glucose
YLR082C	0	292395	293573	ON	12	SRL2	complement(292395..293573)	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YLR083C	0	294092	296095	ON	12	EMP70	complement(294092..296095)	Protein whose 24kDa cleavage product is found in endosome-enriched membrane fractions, predicted to be a transmembrane protein
YLR084C	0	296590	300252	ON	12	RAX2	complement(296590..300252)	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YLR085C	0	300674	301990	ON	12	ARP6	complement(300674..301990)	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YLR086W	1	302244	306500	ON	12	SMC4	(302244..306500)	Subunit of the condensin complex, which reorganizes chromosomes during cell division, forms a stable complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity and promotes knotting of circular DNA; potential Cdc28p substrate
YLR087C	0	306856	315732	ON	12	CSF1	complement(306856..315732)	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR088W	1	316108	317952	ON	12	GAA1	(316108..317952)	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
YLR089C	0	318238	320016	ON	12	YLR089C	complement(318238..320016)	Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR090W	1	320702	322081	ON	12	XDJ1	(320702..322081)	Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR091W	1	322298	323179	ON	12	YLR091W	(322298..323179)	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR091W is not an esssential gene
YLR092W	1	323545	326226	ON	12	SUL2	(323545..326226)	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YLR093C	0	326514	327416	ON	12	NYV1	complement(326514..327259,327401..327416)	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
YLR094C	0	327731	329239	ON	12	GIS3	complement(327731..329239)	Protein of unknown function
YLR095C	0	329678	332116	ON	12	IOC2	complement(329678..332116)	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
YLR096W	1	332591	336034	ON	12	KIN2	(332591..336034)	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
YLR097C	0	336232	337266	ON	12	HRT3	complement(336232..337266)	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
YLR098C	0	337528	339474	ON	12	CHA4	complement(337528..339474)	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
YLR099C	0	339745	340929	ON	12	ICT1	complement(339745..340929)	Protein of unknown function, null mutation leads to an increase in sensitivity to Calcofluor white; expression of the gene is induced in the presence of isooctane
YLR099W-A	1	341326	341589	ON	12	YLR099W-A	(341326..341589)	Putative protein of unknown function
YLR100W	1	341811	342854	ON	12	ERG27	(341811..342854)	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
YLR101C	0	342567	342962	OFF	12	YLR101C	complement(342567..342962)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
YLR102C	0	342971	343768	ON	12	APC9	complement(342971..343768)	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YLR103C	0	343990	345942	ON	12	CDC45	complement(343990..345942)	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
YLR104W	1	346586	346981	ON	12	YLR104W	(346586..346981)	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate
YLR105C	0	347048	348181	ON	12	SEN2	complement(347048..348181)	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YLR106C	0	349007	363739	ON	12	MDN1	complement(349007..363739)	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm
YLR107W	1	364117	365331	ON	12	REX3	(364117..365331)	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
YLR108C	0	366668	368125	ON	12	YLR108C	complement(366668..368125)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YLR109W	1	368782	369312	ON	12	AHP1	(368782..369312)	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YLR110C	0	369698	370099	ON	12	CCW12	complement(369698..370099)	Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YLR111W	1	370392	370724	OFF	12	YLR111W	(370392..370724)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR112W	1	370792	371211	OFF	12	YLR112W	(370792..371211)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR113W	1	371621	372928	ON	12	HOG1	(371621..372928)	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YLR114C	0	374945	377239	ON	12	AVL9	complement(374945..377239)	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms
YLR115W	1	377986	380565	ON	12	CFT2	(377986..380565)	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
YLR116W	1	380823	382253	ON	12	MSL5	(380823..382253)	Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
YLR117C	0	382472	384535	ON	12	CLF1	complement(382472..384535)	Essential splicesome assembly factor; contains multiple tetratricopeptide repeat (TPR) protein-binding motifs and interacts specifically with many spliceosome components, may serve as a scaffold during splicesome assembly
YLR118C	0	384726	385409	ON	12	YLR118C	complement(384726..385409)	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
YLR119W	1	385535	386176	ON	12	SRN2	(385535..386176)	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
YLR120C	0	386512	388221	ON	12	YPS1	complement(386512..388221)	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR120W-A	1	388673	388774	OFF	12	YLR120W-A	(388673..388774)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ORF YLR121C
YLR121C	0	388745	390271	ON	12	YPS3	complement(388745..390271)	Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR122C	0	390955	391332	OFF	12	YLR122C	complement(390955..391332)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YLR123C	0	391079	391408	OFF	12	YLR123C	complement(391079..391408)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR124W	1	391601	391945	OFF	12	YLR124W	(391601..391945)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR125W	1	393485	393895	ON	12	YLR125W	(393485..393895)	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YLR126C	0	394766	395521	ON	12	YLR126C	complement(394766..395521)	Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein
YLR127C	0	395759	398320	ON	12	APC2	complement(395759..398320)	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p
YLR128W	1	398531	399434	ON	12	DCN1	(398531..398533,398628..399434)	Putative Nedd8 ligase; binds Nedd8; involved in cullin neddylation; not essential; similar to C.elegans DCN-1; contains UBA-like ubiquitin-binding domain and a DUF298 domain
YLR129W	1	399658	402489	ON	12	DIP2	(399658..402489)	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YLR130C	0	402795	404063	ON	12	ZRT2	complement(402795..404063)	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YLR131C	0	404511	406823	ON	12	ACE2	complement(404511..406823)	Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
YLR132C	0	407284	408156	ON	12	YLR132C	complement(407284..408156)	Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YLR133W	1	408446	410194	ON	12	CKI1	(408446..410194)	Choline kinase, catalyzes the first step in the CDP-choline pathway phosphatidylcholine synthesis (Kennedy pathway); mRNA expression is regulated by inositol and choline, enzyme activity is stimulated by phosphorylation by protein kinase
YLR134W	1	410724	412415	ON	12	PDC5	(410724..412415)	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
YLR135W	1	413282	415528	ON	12	SLX4	(413282..415528)	Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YLR136C	0	415802	416659	ON	12	TIS11	complement(415802..416659)	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YLR137W	1	417007	418110	ON	12	YLR137W	(417007..418110)	Putative protein of unknown function
YLR138W	1	418438	421395	ON	12	NHA1	(418438..421395)	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
YLR139C	0	421543	423474	ON	12	SLS1	complement(421543..423474)	Mitochondrial membrane protein required for assembly of respiratory-chain enzyme complexes III and IV; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
YLR140W	1	423475	423801	OFF	12	YLR140W	(423475..423801)	Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YLR141W	1	423684	424775	ON	12	RRN5	(423684..424775)	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
YLR142W	1	425187	426617	ON	12	PUT1	(425187..426617)	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YLR143W	1	427330	429387	ON	12	YLR143W	(427330..429387)	Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
YLR144C	0	429678	432017	ON	12	ACF2	complement(429678..432017)	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
YLR145W	1	432169	432774	ON	12	RMP1	(432169..432774)	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YLR146C	0	432824	433726	ON	12	SPE4	complement(432824..433726)	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YLR146W-A	1	433871	434059	ON	12	YLR146W-A	(433871..434059)	Putative protein of unknown function
YLR147C	0	434159	434464	ON	12	SMD3	complement(434159..434464)	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
YLR148W	1	434642	437398	ON	12	PEP3	(434642..437398)	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
YLR149C	0	437632	439824	ON	12	YLR149C	complement(437632..439824)	Putative protein of unknown function; YLR149C is not an essential gene
YLR149C-A	0	440371	440457	OFF	12	YLR149C-A	complement(440371..440457)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR150W	1	440468	441289	ON	12	STM1	(440468..441289)	Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YLR151C	0	441716	442738	ON	12	PCD1	complement(441716..442738)	Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids
YLR152C	0	442959	444689	ON	12	YLR152C	complement(442959..444689)	Putative protein of unknown function; YLR152C is not an essential gene
YLR153C	0	445525	447576	ON	12	ACS2	complement(445525..447576)	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YLR154C	0	447983	448315	ON	12	RNH203	complement(447983..448315)	Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-A	1	452439	452624	OFF	12	YLR154W-A	(452439..452624)	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B	1	454393	454557	OFF	12	YLR154W-B	(454393..454557)	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-C	1	454697	455071	OFF	12	TAR1	(454697..455071)	Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YLR154W-E	1	455434	455637	OFF	12	YLR154W-E	(455434..455637)	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand
YLR154W-F	1	455884	456024	OFF	12	YLR154W-F	(455884..456024)	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand
YLR154C-G	0	462523	462672	OFF	12	YLR154C-G	complement(462523..462672)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2
YLR154C-H	0	468828	468959	OFF	12	YLR154C-H	complement(468828..468959)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2
YLR155C	0	469318	470406	ON	12	ASP3-1	complement(469318..470406)	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C
YLR156W	1	472114	472458	OFF	12	YLR156W	(472114..472458)	Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis
YLR156C-A	0	472480	472611	OFF	12	YLR156C-A	complement(472480..472611)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3
YLR157C	0	472970	474058	ON	12	ASP3-2	complement(472970..474058)	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C
YLR157W-D	1	475765	475977	OFF	12	YLR157W-D	(475765..475977)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR157W-E	1	481874	482038	OFF	12	YLR157W-E	(481874..482038)	Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element
YLR157C-C	0	482060	482191	OFF	12	YLR157C-C	complement(482060..482191)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4
YLR158C	0	482550	483638	ON	12	ASP3-3	complement(482550..483638)	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C
YLR159W	1	485346	485690	OFF	12	YLR159W	(485346..485690)	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12
YLR159C-A	0	485712	485843	OFF	12	YLR159C-A	complement(485712..485843)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5
YLR160C	0	486202	487290	ON	12	ASP3-4	complement(486202..487290)	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C
YLR161W	1	488998	489342	OFF	12	YLR161W	(488998..489342)	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12
YLR162W	1	489574	489930	OFF	12	YLR162W	(489574..489930)	Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1
YLR162W-A	1	490407	490595	OFF	12	YLR162W-A	(490407..490595)	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YLR163C	0	491868	493256	ON	12	MAS1	complement(491868..493256)	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YLR163W-A	1	492814	492927	OFF	12	YLR163W-A	(492814..492927)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLR164W	1	493885	494391	ON	12	YLR164W	(493885..494391)	Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR165C	0	494496	495260	ON	12	PUS5	complement(494496..495260)	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
YLR166C	0	495431	498046	ON	12	SEC10	complement(495431..498046)	Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
YLR167W	1	498949	499407	ON	12	RPS31	(498949..499407)	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YLR168C	0	499580	500272	ON	12	YLR168C	complement(499580..500272)	Putative protein of unknown function that may be involved in intramitochondrial sorting; has similarity to Ups1p and to human PRELI; the green fluorescent protein (GFP)-tagged protein localizes to mitochondria
YLR169W	1	500337	500690	OFF	12	YLR169W	(500337..500690)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR170C	0	500581	501051	ON	12	APS1	complement(500581..501051)	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
YLR171W	1	500735	501124	OFF	12	YLR171W	(500735..501124)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR172C	0	501262	502164	ON	12	DPH5	complement(501262..502164)	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
YLR173W	1	502423	504249	ON	12	YLR173W	(502423..504249)	Putative protein of unknown function
YLR174W	1	504593	505831	ON	12	IDP2	(504593..505831)	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YLR175W	1	506136	507587	ON	12	CBF5	(506136..507587)	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
YLR176C	0	507799	510234	ON	12	RFX1	complement(507799..510234)	Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins
YLR177W	1	511056	512942	ON	12	YLR177W	(511056..512942)	Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YLR178C	0	513164	513823	ON	12	TFS1	complement(513164..513823)	Carboxypeptidase Y inhibitor, function requires acetylation by the NatB N-terminal acetyltransferase; phosphatidylethanolamine-binding protein involved in protein kinase A signaling pathway
YLR179C	0	514110	514715	ON	12	YLR179C	complement(514110..514715)	Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YLR180W	1	515264	516412	ON	12	SAM1	(515264..516412)	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YLR181C	0	516680	517672	ON	12	VTA1	complement(516680..517672)	Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects
YLR182W	1	517942	520353	ON	12	SWI6	(517942..520353)	Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
YLR183C	0	520545	522014	ON	12	TOS4	complement(520545..522014)	Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YLR184W	1	522108	522455	OFF	12	YLR184W	(522108..522455)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR185W	1	522665	523290	ON	12	RPL37A	(522665..522671,523031..523290)	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YLR186W	1	523634	524392	ON	12	EMG1	(523634..524392)	Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAs
YLR187W	1	524867	527947	ON	12	SKG3	(524867..527947)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
YLR188W	1	528302	530389	ON	12	MDL1	(528302..530389)	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
YLR189C	0	530799	534395	ON	12	ATG26	complement(530799..534395)	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids, involved in autophagy
YLR190W	1	535216	536691	ON	12	MMR1	(535216..536691)	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YLR191W	1	537274	538434	ON	12	PEX13	(537274..538434)	Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YLR192C	0	538794	539591	ON	12	HCR1	complement(538794..539591)	Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YLR193C	0	540011	540538	ON	12	UPS1	complement(540011..540538)	Mitochondrial intermembrane space protein that regulates alternative processing and sorting of Mgm1p and other proteins; required for normal mitochondrial morphology; ortholog of human PRELI
YLR194C	0	540811	541575	ON	12	YLR194C	complement(540811..541575)	Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
YLR195C	0	541939	543306	ON	12	NMT1	complement(541939..543306)	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YLR196W	1	543970	545700	ON	12	PWP1	(543970..545700)	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YLR197W	1	546099	547613	ON	12	SIK1	(546099..547613)	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YLR198C	0	547288	547647	OFF	12	YLR198C	complement(547288..547647)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YLR199C	0	547855	548771	ON	12	PBA1	complement(547855..548679,548766..548771)	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
YLR200W	1	549014	549358	ON	12	YKE2	(549014..549358)	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
YLR201C	0	549513	550295	ON	12	COQ9	complement(549513..550295)	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
YLR202C	0	550196	550638	OFF	12	YLR202C	complement(550196..550460,550577..550638)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
YLR203C	0	550652	551962	ON	12	MSS51	complement(550652..551962)	Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YLR204W	1	552272	552607	ON	12	QRI5	(552272..552607)	Mitochondrial protein of unknown function
YLR205C	0	552726	553679	ON	12	HMX1	complement(552726..553679)	ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YLR206W	1	554580	556421	ON	12	ENT2	(554580..556421)	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YLR207W	1	556790	559291	ON	12	HRD3	(556790..559291)	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
YLR208W	1	559553	560446	ON	12	SEC13	(559553..560446)	Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles
YLR209C	0	560799	561734	ON	12	PNP1	complement(560799..561734)	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides
YLR210W	1	562010	563392	ON	12	CLB4	(562010..563392)	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YLR211C	0	563794	564533	ON	12	YLR211C	complement(563794..564456,564516..564533)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
YLR212C	0	564862	566283	ON	12	TUB4	complement(564862..566283)	Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YLR213C	0	566656	567924	ON	12	CRR1	complement(566656..567924)	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YLR214W	1	568569	570629	ON	12	FRE1	(568569..570629)	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YLR215C	0	570778	571860	ON	12	CDC123	complement(570778..571860)	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YLR216C	0	572098	573213	ON	12	CPR6	complement(572098..573213)	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YLR217W	1	572911	573234	OFF	12	YLR217W	(572911..573234)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YLR218C	0	573468	573920	ON	12	YLR218C	complement(573468..573920)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR218C is not essential; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source
YLR219W	1	574153	576339	ON	12	MSC3	(574153..576339)	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate
YLR220W	1	576827	577795	ON	12	CCC1	(576827..577795)	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
YLR221C	0	578364	579026	ON	12	RSA3	complement(578364..579026)	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YLR222C	0	579320	581773	ON	12	UTP13	complement(579320..581773)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLR222C-A	0	582008	582238	OFF	12	YLR222C-A	complement(582008..582238)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1
YLR223C	0	582235	585492	ON	12	IFH1	complement(582235..585492)	Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
YLR224W	1	586466	587575	ON	12	YLR224W	(586466..587575)	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YLR225C	0	587697	588920	ON	12	YLR225C	complement(587697..588920)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
YLR226W	1	589356	590543	ON	12	BUR2	(589356..590543)	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
YLR227C	0	590564	592045	ON	12	ADY4	complement(590564..592045)	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YLR228C	0	600021	602465	ON	12	ECM22	complement(600021..602465)	Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YLR229C	0	604214	604789	ON	12	CDC42	complement(604214..604789)	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YLR230W	1	604576	604881	OFF	12	YLR230W	(604576..604881)	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YLR231C	0	605760	607121	ON	12	BNA5	complement(605760..607121)	Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathway
YLR232W	1	606832	607179	OFF	12	YLR232W	(606832..607179)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
YLR233C	0	607427	609526	ON	12	EST1	complement(607427..609526)	TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere
YLR234W	1	609785	611755	ON	12	TOP3	(609785..611755)	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
YLR235C	0	611534	611932	OFF	12	YLR235C	complement(611534..611932)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YLR236C	0	611796	612119	OFF	12	YLR236C	complement(611796..612119)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR237W	1	612369	614165	ON	12	THI7	(612369..614165)	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YLR238W	1	614757	616193	ON	12	FAR10	(614757..616193)	Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
YLR239C	0	616334	617320	ON	12	LIP2	complement(616334..617320)	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
YLR240W	1	617535	620162	ON	12	VPS34	(617535..620162)	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p
YLR241W	1	620475	622823	ON	12	YLR241W	(620475..622823)	Putative protein of unknown function, may be involved in detoxification
YLR242C	0	622920	623885	ON	12	ARV1	complement(622920..623885)	Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein
YLR243W	1	624205	625023	ON	12	YLR243W	(624205..625023)	Putative protein of unknown function; YLR243W is an essential gene
YLR244C	0	625170	626333	ON	12	MAP1	complement(625170..626333)	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
YLR245C	0	626504	626932	ON	12	CDD1	complement(626504..626932)	Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm
YLR246W	1	627120	628199	ON	12	ERF2	(627120..628199)	Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole
YLR247C	0	628686	633356	ON	12	YLR247C	complement(628686..633356)	Putative helicase; localized to mitochondria and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52 foci
YLR248W	1	634254	636086	ON	12	RCK2	(634254..636086)	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YLR249W	1	636782	639916	ON	12	YEF3	(636782..639916)	Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YLR250W	1	640319	641023	ON	12	SSP120	(640319..641023)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR251W	1	641466	642059	ON	12	SYM1	(641466..642059)	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
YLR252W	1	641959	642264	OFF	12	YLR252W	(641959..642264)	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YLR253W	1	642629	644338	ON	12	YLR253W	(642629..644338)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
YLR254C	0	644406	644975	ON	12	NDL1	complement(644406..644975)	Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YLR255C	0	645602	645955	OFF	12	YLR255C	complement(645602..645955)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR256W	1	646417	650925	ON	12	HAP1	(646417..650925)	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YLR257W	1	658828	659793	ON	12	YLR257W	(658828..659793)	Putative protein of unknown function
YLR258W	1	660718	662835	ON	12	GSY2	(660718..662835)	Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YLR259C	0	663286	665004	ON	12	HSP60	complement(663286..665004)	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; similarity to groEL
YLR260W	1	665846	667909	ON	12	LCB5	(665846..667909)	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YLR261C	0	668239	668565	OFF	12	VPS63	complement(668239..668565)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YLR262C	0	668246	668893	ON	12	YPT6	complement(668246..668893)	GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YLR262C-A	0	669470	669664	ON	12	TMA7	complement(669470..669664)	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
YLR263W	1	670342	672825	ON	12	RED1	(670342..672825)	Protein component of the axial elements of the synaptonemal complex, involved in chromosome segregation during the first meiotic division; interacts with Hop1p; required for wild-type levels of Mek1p kinase activity
YLR264W	1	673133	673336	ON	12	RPS28B	(673133..673336)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein
YLR264C-A	0	673830	673946	OFF	12	YLR264C-A	complement(673830..673946)	Putative protein of unknown function
YLR265C	0	674429	675457	ON	12	NEJ1	complement(674429..675457)	Protein involved in regulation of nonhomologous end joining; repressed by MAT heterozygosity; associates with Lif1p and regulates its cellular distribution
YLR266C	0	675621	677726	ON	12	PDR8	complement(675621..677726)	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YLR267W	1	678214	679926	ON	12	YLR267W	(678214..679926)	Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YLR268W	1	680202	680846	ON	12	SEC22	(680202..680846)	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YLR269C	0	680868	681218	OFF	12	YLR269C	complement(680868..681218)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR270W	1	681188	682240	ON	12	DCS1	(681188..682240)	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p
YLR271W	1	682739	683563	ON	12	YLR271W	(682739..683563)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YLR272C	0	683674	687204	ON	12	YCS4	complement(683674..687204)	Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus
YLR273C	0	689085	691031	ON	12	PIG1	complement(689085..691031)	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YLR274W	1	691557	693884	ON	12	CDC46	(691557..693884)	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YLR275W	1	694380	694802	ON	12	SMD2	(694380..694384,694475..694802)	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YLR276C	0	695048	696832	ON	12	DBP9	complement(695048..696832)	ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
YLR277C	0	697158	699497	ON	12	YSH1	complement(697158..699497)	Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs
YLR278C	0	700001	704026	ON	12	YLR278C	complement(700001..704026)	Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YLR279W	1	704311	704700	OFF	12	YLR279W	(704311..704700)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR280C	0	704485	704835	OFF	12	YLR280C	complement(704485..704835)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR281C	0	704495	704962	ON	12	YLR281C	complement(704495..704962)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YLR282C	0	705073	705414	OFF	12	YLR282C	complement(705073..705414)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR283W	1	705188	706132	ON	12	YLR283W	(705188..706132)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
YLR284C	0	706200	707042	ON	12	ECI1	complement(706200..707042)	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
YLR285W	1	707362	708147	ON	12	NNT1	(707362..708147)	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YLR285C-A	0	708170	708340	OFF	12	YLR285C-A	complement(708170..708340)	Putative protein of unknown function; identified by fungal homology and RT-PCR
YLR286C	0	708450	710138	ON	12	CTS1	complement(708450..710138)	Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YLR286W-A	1	708564	708698	OFF	12	YLR286W-A	(708564..708698)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1
YLR287C	0	710993	712060	ON	12	YLR287C	complement(710993..712060)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
YLR287C-A	0	712539	713160	ON	12	RPS30A	complement(712539..712727,713158..713160)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YLR288C	0	713482	714906	ON	12	MEC3	complement(713482..714906)	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
YLR289W	1	715091	717028	ON	12	GUF1	(715091..717028)	Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans
YLR290C	0	717147	717980	ON	12	YLR290C	complement(717147..717980)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
YLR291C	0	718319	719464	ON	12	GCD7	complement(718319..719464)	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YLR292C	0	719791	720372	ON	12	SEC72	complement(719791..720372)	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YLR293C	0	720773	721432	ON	12	GSP1	complement(720773..721432)	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
YLR294C	0	721703	722032	OFF	12	YLR294C	complement(721703..722032)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YLR295C	0	722001	722375	ON	12	ATP14	complement(722001..722375)	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YLR296W	1	722980	723306	OFF	12	YLR296W	(722980..723306)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR297W	1	724046	724435	ON	12	YLR297W	(724046..724435)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene
YLR298C	0	724723	725418	ON	12	YHC1	complement(724723..725418)	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YLR299W	1	726071	728053	ON	12	ECM38	(726071..728053)	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; expression induced mainly by nitrogen starvation
YLR299C-A	0	727913	728005	OFF	12	YLR299C-A	complement(727913..728005)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38
YLR300W	1	728957	730303	ON	12	EXG1	(728957..730303)	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YLR301W	1	730827	731561	ON	12	YLR301W	(730827..731561)	Protein of unknown function that interacts with Sec72p
YLR302C	0	732193	732555	OFF	12	YLR302C	complement(732193..732555)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR303W	1	732544	733878	ON	12	MET17	(732544..733878)	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
YLR304C	0	735214	737550	ON	12	ACO1	complement(735214..737550)	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
YLR305C	0	738163	743865	ON	12	STT4	complement(738163..743865)	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
YLR306W	1	744153	744853	ON	12	UBC12	(744153..744155,744290..744853)	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
YLR307W	1	745622	746527	ON	12	CDA1	(745622..746527)	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YLR307C-A	0	746850	747113	ON	12	YLR307C-A	complement(746850..747113)	Putative protein of unknown function
YLR308W	1	747939	748877	ON	12	CDA2	(747939..748877)	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YLR309C	0	749036	751771	ON	12	IMH1	complement(749036..751771)	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
YLR310C	0	752226	756995	ON	12	CDC25	complement(752226..756995)	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
YLR311C	0	757267	757614	OFF	12	YLR311C	complement(757267..757614)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR312C	0	757639	758835	ON	12	YLR312C	complement(757639..758835)	Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YLR312W-A	1	759482	760243	ON	12	MRPL15	(759482..760243)	Mitochondrial ribosomal protein of the large subunit
YLR313C	0	760357	762342	ON	12	SPH1	complement(760357..762342)	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YLR314C	0	762575	764137	ON	12	CDC3	complement(762575..764137)	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YLR315W	1	764808	765269	ON	12	NKP2	(764808..765269)	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)
YLR316C	0	765266	766358	ON	12	TAD3	complement(765266..766073,766130..766181,766250..766358)	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
YLR317W	1	765655	766089	OFF	12	YLR317W	(765655..766089)	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
YLR318W	1	766542	769196	ON	12	EST2	(766542..769196)	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
YLR319C	0	769318	771684	ON	12	BUD6	complement(769318..771684)	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
YLR320W	1	771940	776304	ON	12	MMS22	(771940..776304)	Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks
YLR321C	0	776584	777864	ON	12	SFH1	complement(776584..777864)	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YLR322W	1	777628	777942	OFF	12	VPS65	(777628..777942)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect
YLR323C	0	778173	778952	ON	12	CWC24	complement(778173..778952)	Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p
YLR324W	1	779215	780786	ON	12	PEX30	(779215..780786)	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YLR325C	0	781143	781379	ON	12	RPL38	complement(781143..781379)	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YLR326W	1	782174	782896	ON	12	YLR326W	(782174..782896)	Hypothetical protein
YLR327C	0	783127	783387	ON	12	TMA10	complement(783127..783387)	Protein of unknown function that associates with ribosomes
YLR328W	1	784913	786118	ON	12	NMA1	(784913..786118)	Nicotinic acid mononucleotide adenylyltransferase, involved in NAD(+) salvage pathway
YLR329W	1	786442	787333	ON	12	REC102	(786442..786615,786713..787333)	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YLR330W	1	787664	789679	ON	12	CHS5	(787664..789679)	Protein involved in export from the Golgi to plasma membrane; involved in chitin biosynthesis through its role in Chs3p localization; interacts with Arf1p, Bch1p, Fmp50p, Bud7p, and Chs6p
YLR331C	0	790669	791046	OFF	12	JIP3	complement(790669..791046)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YLR332W	1	790676	791806	ON	12	MID2	(790676..791806)	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YLR333C	0	795573	795899	ON	12	RPS25B	complement(795573..795899)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YLR334C	0	796698	797078	OFF	12	YLR334C	complement(796698..797078)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here
YLR335W	1	797430	799592	ON	12	NUP2	(797430..799592)	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YLR336C	0	799697	802396	ON	12	SGD1	complement(799697..802396)	Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YLR337C	0	802653	805106	ON	12	VRP1	complement(802653..805106)	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YLR338W	1	804346	805203	OFF	12	OPI9	(804346..805203)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
YLR339C	0	805784	806335	OFF	12	YLR339C	complement(805784..806335)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YLR340W	1	805887	806825	ON	12	RPP0	(805887..806825)	Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YLR341W	1	807385	808818	ON	12	SPO77	(807385..808818)	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YLR342W	1	809997	815627	ON	12	FKS1	(809997..815627)	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YLR342W-A	1	815810	815983	OFF	12	YLR342W-A	(815810..815983)	Putative protein of unknown function
YLR343W	1	816094	817761	ON	12	GAS2	(816094..817761)	1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
YLR344W	1	819312	820142	ON	12	RPL26A	(819312..819330,819778..820142)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YLR345W	1	820511	822040	ON	12	YLR345W	(820511..822040)	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
YLR346C	0	822287	822592	ON	12	YLR346C	complement(822287..822592)	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YLR347C	0	823827	826412	ON	12	KAP95	complement(823827..826412)	Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex
YLR347W-A	1	824788	824928	OFF	12	YLR347W-A	(824788..824928)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C
YLR348C	0	826976	827872	ON	12	DIC1	complement(826976..827872)	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YLR349W	1	827520	828026	OFF	12	YLR349W	(827520..828026)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YLR350W	1	828729	829379	ON	12	ORM2	(828729..829379)	Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YLR351C	0	829488	830363	ON	12	NIT3	complement(829488..830363)	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YLR352W	1	831115	833538	ON	12	YLR352W	(831115..833538)	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YLR353W	1	834351	836162	ON	12	BUD8	(834351..836162)	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YLR354C	0	836349	837356	ON	12	TAL1	complement(836349..837356)	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
YLR355C	0	838065	839252	ON	12	ILV5	complement(838065..839252)	Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA
YLR356W	1	840320	840913	ON	12	YLR356W	(840320..840913)	Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YLR357W	1	841330	843999	ON	12	RSC2	(841330..843999)	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YLR358C	0	843486	844049	OFF	12	YLR358C	complement(843486..844049)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W
YLR359W	1	844281	845729	ON	12	ADE13	(844281..845729)	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
YLR360W	1	846102	847421	ON	12	VPS38	(846102..847421)	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity
YLR361C	0	847387	849123	ON	12	DCR2	complement(847387..849123)	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
YLR361C-A	0	849382	849678	ON	12	YLR361C-A	complement(849382..849678)	Putative protein of unknown function
YLR362W	1	849865	852018	ON	12	STE11	(849865..852018)	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p
YLR363C	0	852494	853150	ON	12	NMD4	complement(852494..853150)	Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway
YLR363W-A	1	853460	853717	ON	12	YLR363W-A	(853460..853717)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YLR364W	1	854061	854390	ON	12	YLR364W	(854061..854390)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR364W is not an essential gene
YLR365W	1	855198	855530	OFF	12	YLR365W	(855198..855530)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YLR364C-A	0	855522	855644	OFF	12	YLR364C-A	complement(855522..855644)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W
YLR366W	1	855537	855842	OFF	12	YLR366W	(855537..855842)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YLR367W	1	856441	857316	ON	12	RPS22B	(856441..856573,857057..857316)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YLR368W	1	857539	859335	ON	12	MDM30	(857539..859335)	F-box protein; physically associates with mitochondria and is required for normal mitochondrial fusion in rich medium, during sporulation, and in mating cells; promotes ubiquitin-mediated degradation of Gal4p in some strains
YLR369W	1	859551	861524	ON	12	SSQ1	(859551..861524)	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
YLR370C	0	861717	862253	ON	12	ARC18	complement(861717..862253)	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YLR371W	1	862713	866783	ON	12	ROM2	(862713..866783)	GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP
YLR372W	1	867353	868390	ON	12	SUR4	(867353..868390)	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YLR373C	0	868661	871366	ON	12	VID22	complement(868661..871366)	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
YLR374C	0	871452	871841	OFF	12	YLR374C	complement(871452..871841)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YLR375W	1	871696	872727	ON	12	STP3	(871696..872727)	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YLR376C	0	872825	873553	ON	12	PSY3	complement(872825..873553)	Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
YLR377C	0	873745	874791	ON	12	FBP1	complement(873745..874791)	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YLR378C	0	875735	877177	ON	12	SEC61	complement(875735..877177)	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YLR379W	1	876921	877295	OFF	12	YLR379W	(876921..877295)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
YLR380W	1	878282	879508	ON	12	CSR1	(878282..879508)	Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance
YLR381W	1	879723	881924	ON	12	CTF3	(879723..881924)	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
YLR382C	0	882067	884751	ON	12	NAM2	complement(882067..884751)	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
YLR383W	1	885288	888632	ON	12	SMC6	(885288..888632)	Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
YLR384C	0	888851	892900	ON	12	IKI3	complement(888851..892900)	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YLR385C	0	892992	893390	ON	12	SWC7	complement(892992..893390)	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
YLR386W	1	893628	896270	ON	12	VAC14	(893628..896270)	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YLR387C	0	896374	897672	ON	12	REH1	complement(896374..897672)	Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains
YLR388W	1	898651	898821	ON	12	RPS29A	(898651..898821)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YLR389C	0	899577	902660	ON	12	STE23	complement(899577..902660)	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family
YLR390W	1	903066	903404	ON	12	ECM19	(903066..903404)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR390W-A	1	903724	904440	ON	12	CCW14	(903724..904440)	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YLR392C	0	904749	906305	ON	12	YLR392C	complement(904749..906305)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene
YLR393W	1	907079	907918	ON	12	ATP10	(907079..907918)	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YLR394W	1	907950	909398	ON	12	CST9	(907950..909398)	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
YLR395C	0	909729	909965	ON	12	COX8	complement(909729..909965)	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YLR396C	0	910235	912310	ON	12	VPS33	complement(910235..912310)	ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
YLR397C	0	912550	914892	ON	12	AFG2	complement(912550..914892)	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs
YLR398C	0	915156	919019	ON	12	SKI2	complement(915156..919019)	Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses
YLR399C	0	919536	921596	ON	12	BDF1	complement(919536..921596)	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YLR399W-A	1	920869	920973	OFF	12	YLR399W-A	(920869..920973)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C
YLR400W	1	922063	922536	OFF	12	YLR400W	(922063..922536)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR401C	0	922442	924448	ON	12	DUS3	complement(922442..924448)	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YLR402W	1	924564	925079	OFF	12	YLR402W	(924564..925079)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR403W	1	925567	927618	ON	12	SFP1	(925567..927618)	Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLR404W	1	928742	929599	ON	12	YLR404W	(928742..929599)	Putative protein of unknown function; may be an integral membrane protein; YLR404W is not an essential gene
YLR405W	1	929788	930891	ON	12	DUS4	(929788..930891)	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
YLR406C	0	931064	931754	ON	12	RPL31B	complement(931064..931348,931698..931754)	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YLR406C-A	0	932205	932354	OFF	12	YLR406C-A	complement(932205..932354)	Putative protein of unknown function
YLR407W	1	932966	933655	ON	12	YLR407W	(932966..933655)	Putative protein of unknown function; YLR407W is not an essential gene
YLR408C	0	933883	934251	ON	12	YLR408C	complement(933883..934251)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
YLR409C	0	934412	937231	ON	12	UTP21	complement(934412..937231)	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR410W	1	937539	940979	ON	12	VIP1	(937539..940979)	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of IP7 by Vip1p is important for phosphate signaling; likely involved in cortical actin cytoskeleton function, by analogy with S. pombe ortholog asp1
YLR411W	1	947251	947976	ON	12	CTR3	(947251..947976)	High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YLR412W	1	948366	949190	ON	12	YLR412W	(948366..949190)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene
YLR412C-A	0	950264	950470	OFF	12	YLR412C-A	complement(950264..950470)	Putative protein of unknown function
YLR413W	1	951153	953180	ON	12	YLR413W	(951153..953180)	Putative protein of unknown function; YLR413W is not an essential gene
YLR414C	0	953350	954141	ON	12	YLR414C	complement(953350..954141)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene
YLR415C	0	954256	954594	OFF	12	YLR415C	complement(954256..954594)	Putative protein of unknown function; YLR415C is not an essential gene
YLR416C	0	954488	954886	OFF	12	YLR416C	complement(954488..954886)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR417W	1	955007	956707	ON	12	VPS36	(955007..956707)	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
YLR418C	0	956911	958092	ON	12	CDC73	complement(956911..958092)	Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
YLR419W	1	958425	962732	ON	12	YLR419W	(958425..962732)	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
YLR420W	1	963782	964876	ON	12	URA4	(963782..964876)	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YLR421C	0	965087	965557	ON	12	RPN13	complement(965087..965557)	Subunit of the 19S regulatory particle of the 26S proteasome lid
YLR422W	1	965894	971692	ON	12	YLR422W	(965894..971692)	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
YLR423C	0	971914	973167	ON	12	ATG17	complement(971914..973167)	Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
YLR424W	1	973392	975518	ON	12	SPP382	(973392..975518)	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
YLR425W	1	982891	986814	ON	12	TUS1	(982891..986814)	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YLR426W	1	987059	988110	ON	12	YLR426W	(987059..987138,987210..988110)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin
YLR427W	1	988425	990437	ON	12	MAG2	(988425..990437)	Cytoplasmic protein of unknown function predicted to encode a DNA-3-methyladenine glycosidase II that catalyzes the hydrolysis of alkylated DNA
YLR428C	0	990614	990958	OFF	12	YLR428C	complement(990614..990958)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
YLR429W	1	990774	992729	ON	12	CRN1	(990774..992729)	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity
YLR430W	1	993431	1000126	ON	12	SEN1	(993431..1000126)	Putative helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis
YLR431C	0	1000339	1001700	ON	12	ATG23	complement(1000339..1001700)	Peripheral membrane protein, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway
YLR432W	1	1002554	1004125	ON	12	IMD3	(1002554..1004125)	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YLR433C	0	1004344	1006005	ON	12	CNA1	complement(1004344..1006005)	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YLR434C	0	1006022	1006405	OFF	12	YLR434C	complement(1006022..1006405)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W
YLR435W	1	1006375	1006992	ON	12	TSR2	(1006375..1006992)	Protein with a potential role in pre-rRNA processing
YLR436C	0	1007418	1011242	ON	12	ECM30	complement(1007418..1011242)	Non-essential protein of unknown function
YLR437C	0	1011619	1012020	ON	12	YLR437C	complement(1011619..1012020)	Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YLR437C-A	0	1012456	1012683	OFF	12	YLR437C-A	complement(1012456..1012683)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YLR438W	1	1012498	1013772	ON	12	CAR2	(1012498..1013772)	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YLR438C-A	0	1013906	1014175	ON	12	LSM3	complement(1013906..1014175)	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR439W	1	1014488	1015447	ON	12	MRPL4	(1014488..1015447)	Mitochondrial ribosomal protein of the large subunit
YLR440C	0	1015565	1017694	ON	12	SEC39	complement(1015565..1017694)	Protein of unknown function proposed to be involved in protein secretion
YLR441C	0	1018138	1018905	ON	12	RPS1A	complement(1018138..1018905)	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YLR442C	0	1019312	1022248	ON	12	SIR3	complement(1019312..1022248)	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YLR443W	1	1022622	1023968	ON	12	ECM7	(1022622..1023968)	Non-essential protein of unknown function
YLR444C	0	1023683	1023985	OFF	12	YLR444C	complement(1023683..1023985)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR445W	1	1024186	1024834	ON	12	YLR445W	(1024186..1024569,1024652..1024834)	Hypothetical protein
YLR446W	1	1025211	1026512	ON	12	YLR446W	(1025211..1026512)	Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
YLR447C	0	1026853	1027890	ON	12	VMA6	complement(1026853..1027890)	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YLR448W	1	1028850	1029764	ON	12	RPL6B	(1028850..1028864,1029249..1029764)	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YLR449W	1	1030830	1032008	ON	12	FPR4	(1030830..1032008)	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YLR450W	1	1032624	1035761	ON	12	HMG2	(1032624..1035761)	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks
YLR451W	1	1036090	1038750	ON	12	LEU3	(1036090..1038750)	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
YLR452C	0	1039268	1041364	ON	12	SST2	complement(1039268..1041364)	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
YLR453C	0	1041797	1042984	ON	12	RIF2	complement(1041797..1042984)	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YLR454W	1	1043996	1051882	ON	12	YLR454W	(1043996..1051882)	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR455W	1	1053627	1054541	ON	12	YLR455W	(1053627..1054541)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YLR456W	1	1055068	1055682	ON	12	YLR456W	(1055068..1055682)	Putative protein of unknown function
YLR457C	0	1055810	1056769	ON	12	NBP1	complement(1055810..1056769)	Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex
YLR458W	1	1056453	1056833	OFF	12	YLR458W	(1056453..1056833)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
YLR459W	1	1057332	1058516	ON	12	GAB1	(1057332..1058516)	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
YLR460C	0	1059755	1060885	ON	12	YLR460C	complement(1059755..1060885)	Putative protein of unknown function, possibly up-regulated by iodine
YLR461W	1	1062917	1063279	ON	12	PAU4	(1062917..1063279)	Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR462W	1	1065954	1066562	ON	12	YLR462W	(1065954..1066562)	Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII
YLR463C	0	1066263	1066814	OFF	12	YLR463C	complement(1066263..1066814)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W
YLR464W	1	1066570	1067499	ON	12	YLR464W	(1066570..1067082,1067362..1067499)	Putative protein of unknown function with similarity to helicases; YLR464W contains an intron and overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C
YLR465C	0	1067043	1067351	OFF	12	BSC3	complement(1067043..1067351)	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4
YLR466W	1	1067085	1071233	ON	12	YRF1-4	(1067085..1071233)	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YLR466C-A	0	1070385	1070867	OFF	12	YLR466C-A	complement(1070385..1070867)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W
YLR466C-B	0	1071592	1071708	OFF	12	YLR466C-B	complement(1071592..1071708)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR467W	1	1072506	1077896	ON	12	YRF1-5	(1072506..1077896)	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YLR467C-A	0	1077048	1077530	OFF	12	YLR467C-A	complement(1077048..1077530)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W
YML133C	0	461	4684	ON	13	YML133C	complement(461..3791,3891..4684)	Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YML133W-B	1	827	1309	OFF	13	YML133W-B	(827..1309)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C
YML133W-A	1	1610	2185	OFF	13	YML133W-A	(1610..2185)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C
YML132W	1	7244	8383	ON	13	COS3	(7244..8383)	Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YML131W	1	10199	11296	ON	13	YML131W	(10199..11296)	Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YML130C	0	11484	13175	ON	13	ERO1	complement(11484..13175)	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YML129C	0	14542	14754	ON	13	COX14	complement(14542..14754)	Mitochondrial membrane protein, required for assembly of cytochrome c oxidase
YML128C	0	15136	16677	ON	13	MSC1	complement(15136..16677)	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML127W	1	17065	18810	ON	13	RSC9	(17065..18810)	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YML126C	0	19061	20536	ON	13	ERG13	complement(19061..20536)	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YML125C	0	20762	21700	ON	13	PGA3	complement(20762..21700)	Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
YML124C	0	22049	23684	ON	13	TUB3	complement(22049..23361,23660..23684)	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p
YML123C	0	24038	25801	ON	13	PHO84	complement(24038..25801)	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YML122C	0	26039	26419	OFF	13	YML122C	complement(26039..26419)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML121W	1	26930	27862	ON	13	GTR1	(26930..27862)	Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
YML120C	0	28266	29807	ON	13	NDI1	complement(28266..29807)	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; homolog of human AMID
YML119W	1	30611	31684	ON	13	YML119W	(30611..31684)	Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YML118W	1	32334	33851	ON	13	NGL3	(32334..33851)	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p
YML117W	1	34243	37647	ON	13	NAB6	(34243..37647)	Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data
YML116W-A	1	37472	37774	OFF	13	YML116W-A	(37472..37774)	Putative protein of unknown function
YML116W	1	38196	39824	ON	13	ATR1	(38196..39824)	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide
YML115C	0	40187	41794	ON	13	VAN1	complement(40187..41794)	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YML114C	0	42043	43575	ON	13	TAF8	complement(42043..43575)	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YML113W	1	44045	44791	ON	13	DAT1	(44045..44791)	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
YML112W	1	45063	45953	ON	13	CTK3	(45063..45953)	Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YML111W	1	46942	49704	ON	13	BUL2	(46942..49704)	Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YML110C	0	50031	50954	ON	13	COQ5	complement(50031..50954)	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YML109W	1	51640	54468	ON	13	ZDS2	(51640..54468)	Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
YML108W	1	54793	55110	ON	13	YML108W	(54793..55110)	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YML107C	0	55265	56269	ON	13	PML39	complement(55265..56269)	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
YML106W	1	56773	57453	ON	13	URA5	(56773..57453)	One of two orotate phosphoribosyltransferase isozymes (see also URA10) that catalyze the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate
YML105C	0	57866	58687	ON	13	SEC65	complement(57866..58687)	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
YML104C	0	58939	62322	ON	13	MDM1	complement(58939..62322)	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
YML103C	0	62582	67549	ON	13	NUP188	complement(62582..67549)	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YML102W	1	68294	69700	ON	13	CAC2	(68294..69700)	Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YML101C-A	0	69409	69726	OFF	13	YML101C-A	complement(69409..69726)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML101C	0	69735	70088	ON	13	CUE4	complement(69735..70088)	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
YML100W-A	1	70138	70311	OFF	13	YML100W-A	(70138..70311)	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YML100W	1	70624	73920	ON	13	TSL1	(70624..73920)	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YML099W-A	1	74229	74558	OFF	13	YML099W-A	(74229..74558)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C
YML099C	0	74398	77040	ON	13	ARG81	complement(74398..77040)	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
YML098W	1	77267	77770	ON	13	TAF13	(77267..77770)	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
YML097C	0	78335	79690	ON	13	VPS9	complement(78335..79690)	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YML096W	1	79909	81486	ON	13	YML096W	(79909..81486)	Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
YML095C	0	81481	82113	ON	13	RAD10	complement(81481..82113)	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
YML094C-A	0	82219	82620	OFF	13	YML094C-A	complement(82219..82620)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
YML094W	1	82275	82849	ON	13	GIM5	(82275..82290,82374..82849)	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YML093W	1	83090	85789	ON	13	UTP14	(83090..85789)	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YML092C	0	85987	86739	ON	13	PRE8	complement(85987..86739)	20S proteasome beta-type subunit
YML091C	0	87123	90731	ON	13	RPM2	complement(87123..90731)	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YML090W	1	90744	91130	OFF	13	YML090W	(90744..91130)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YML089C	0	91041	91409	OFF	13	YML089C	complement(91041..91409)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YML088W	1	92235	94241	ON	13	UFO1	(92235..94241)	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YML087C	0	94431	95369	ON	13	YML087C	complement(94431..95369)	Putative protein of unknown function
YML086C	0	95791	97371	ON	13	ALO1	complement(95791..97371)	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress
YML085C	0	97941	99400	ON	13	TUB1	complement(97941..99259,99376..99400)	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YML084W	1	99489	99797	OFF	13	YML084W	(99489..99797)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML083C	0	99794	101050	ON	13	YML083C	complement(99794..101050)	Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YML082W	1	101862	103811	ON	13	YML082W	(101862..103811)	Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YML081C-A	0	103983	104162	ON	13	ATP18	complement(103983..104162)	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YML081W	1	104777	108532	ON	13	YML081W	(104777..108532)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YML080W	1	108806	110077	ON	13	DUS1	(108806..110077)	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YML079W	1	110247	110852	ON	13	YML079W	(110247..110852)	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
YML078W	1	111002	111550	ON	13	CPR3	(111002..111550)	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
YML077W	1	111865	112344	ON	13	BET5	(111865..112344)	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
YML076C	0	112513	115347	ON	13	WAR1	complement(112513..115347)	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YML075C	0	115734	118898	ON	13	HMG1	complement(115734..118898)	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YML074C	0	120089	121324	ON	13	FPR3	complement(120089..121324)	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YML073C	0	123227	124172	ON	13	RPL6A	complement(123227..123742,124158..124172)	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YML072C	0	124730	129367	ON	13	TCB3	complement(124730..129367)	Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YML071C	0	129749	131572	ON	13	COG8	complement(129749..131572)	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YML070W	1	133475	135229	ON	13	DAK1	(133475..135229)	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YML069W	1	135500	137158	ON	13	POB3	(135500..137158)	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
YML068W	1	137550	138944	ON	13	ITT1	(137550..138944)	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
YML067C	0	139063	140214	ON	13	ERV41	complement(139063..140090,140184..140214)	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
YML066C	0	140424	141533	ON	13	SMA2	complement(140424..141533)	Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YML065W	1	142210	144954	ON	13	ORC1	(142210..144954)	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p
YML064C	0	145139	145876	ON	13	TEM1	complement(145139..145876)	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YML063W	1	146482	147249	ON	13	RPS1B	(146482..147249)	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YML062C	0	147505	148683	ON	13	MFT1	complement(147505..148683)	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
YML061C	0	148953	151532	ON	13	PIF1	complement(148953..151532)	DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
YML060W	1	151871	153001	ON	13	OGG1	(151871..153001)	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YML059C	0	153219	158258	ON	13	NTE1	complement(153219..158258)	Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine
YML058W-A	1	158760	158966	ON	13	HUG1	(158760..158966)	Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
YML058W	1	159383	159697	ON	13	SML1	(159383..159697)	Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YML057C-A	0	160023	160412	OFF	13	YML057C-A	complement(160023..160412)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
YML057W	1	160180	161994	ON	13	CMP2	(160180..161994)	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
YML056C	0	162194	164176	ON	13	IMD4	complement(162194..163308,163717..164176)	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YML055W	1	164790	165326	ON	13	SPC2	(164790..165326)	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
YML054C	0	165533	167308	ON	13	CYB2	complement(165533..167308)	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YML054C-A	0	167623	167781	OFF	13	YML054C-A	complement(167623..167781)	Putative protein of unknown function
YML053C	0	169116	169754	ON	13	YML053C	complement(169116..169754)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YML053C is not an essential gene
YML052W	1	170402	171310	ON	13	SUR7	(170402..171310)	Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
YML051W	1	171594	172901	ON	13	GAL80	(171594..172901)	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
YML050W	1	173139	174074	ON	13	YML050W	(173139..174074)	Putative protein of unknown function; non-essential gene
YML049C	0	174220	178305	ON	13	RSE1	complement(174220..178305)	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
YML048W	1	178426	179637	ON	13	GSF2	(178426..179637)	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YML047W-A	1	179893	180258	OFF	13	YML047W-A	(179893..180258)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML047C	0	180017	181075	ON	13	PRM6	complement(180017..181075)	Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YML046W	1	181474	183363	ON	13	PRP39	(181474..183363)	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
YML043C	0	190244	191767	ON	13	RRN11	complement(190244..191767)	Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YML042W	1	192788	194800	ON	13	CAT2	(192788..194800)	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YML041C	0	194913	195755	ON	13	VPS71	complement(194913..195755)	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YML038C	0	202775	204103	ON	13	YMD8	complement(202775..204103)	Putative nucleotide sugar transporter, has similarity to Vrg4p
YML037C	0	204386	205408	ON	13	YML037C	complement(204386..205408)	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
YML036W	1	205642	206293	ON	13	CGI121	(205642..206097,206204..206293)	Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
YML035C	0	206428	208860	ON	13	AMD1	complement(206428..208860)	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
YML034C-A	0	209428	209826	OFF	13	YML034C-A	complement(209428..209826)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML034W	1	209525	212155	ON	13	SRC1	(209525..211444,211571..212155)	Protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery
YML032C	0	212515	213930	ON	13	RAD52	complement(212515..213930)	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
YML031C-A	0	214086	214421	OFF	13	YML031C-A	complement(214086..214421)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YML031W	1	214189	216156	ON	13	NDC1	(214189..216156)	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YML030W	1	216435	216914	ON	13	YML030W	(216435..216914)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene
YML029W	1	217362	219878	ON	13	USA1	(217362..219878)	Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p
YML028W	1	220138	220728	ON	13	TSA1	(220138..220728)	Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype
YML027W	1	221406	222563	ON	13	YOX1	(221406..222563)	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
YML026C	0	222987	223828	ON	13	RPS18B	complement(222987..223380,223782..223828)	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YML025C	0	224406	225365	ON	13	YML6	complement(224406..225239,225339..225365)	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
YML024W	1	225889	226697	ON	13	RPS17A	(225889..225891,226290..226697)	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YML023C	0	226994	228664	ON	13	NSE5	complement(226994..228664)	Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair
YML022W	1	228937	229500	ON	13	APT1	(228937..229500)	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YML021C	0	229734	230813	ON	13	UNG1	complement(229734..230813)	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
YML020W	1	231149	233143	ON	13	YML020W	(231149..233143)	Putative protein of unknown function
YML019W	1	233457	234455	ON	13	OST6	(233457..234455)	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YML018C	0	234771	235952	ON	13	YML018C	complement(234771..235952)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; YML018C is not an essential gene
YML017W	1	236588	238731	ON	13	PSP2	(236588..236591,236954..238731)	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
YML016C	0	239458	241536	ON	13	PPZ1	complement(239458..241536)	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YML015C	0	241989	243029	ON	13	TAF11	complement(241989..243029)	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YML014W	1	243225	244064	ON	13	TRM9	(243225..244064)	tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response
YML013W	1	244149	245903	ON	13	UBX2	(244149..245903)	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
YML012C-A	0	245537	245914	OFF	13	YML012C-A	complement(245537..245914)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1
YML012W	1	246116	246751	ON	13	ERV25	(246116..246751)	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YML011C	0	246895	247428	ON	13	RAD33	complement(246895..247428)	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YML010W	1	247677	250868	ON	13	SPT5	(247677..250868)	Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
YML009W-B	1	250435	250911	OFF	13	YML009W-B	(250435..250911)	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML009C-A	0	250675	251001	OFF	13	YML009C-A	complement(250675..251001)	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML009C	0	251304	251516	ON	13	MRPL39	complement(251304..251516)	Mitochondrial ribosomal protein of the large subunit
YML008C	0	251839	252990	ON	13	ERG6	complement(251839..252990)	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane
YML007C-A	0	253162	253272	OFF	13	YML007C-A	complement(253162..253272)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
YML007W	1	253848	255800	ON	13	YAP1	(253848..255800)	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxidants
YML006C	0	256092	258416	ON	13	GIS4	complement(256092..258416)	CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YML005W	1	260221	261609	ON	13	TRM12	(260221..261609)	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YML004C	0	261705	262685	ON	13	GLO1	complement(261705..262685)	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
YML003W	1	263483	264355	OFF	13	YML003W	(263483..264355)	Putative protein of unknown function
YML002W	1	264541	266754	ON	13	YML002W	(264541..266754)	Putative protein of unknown function; expression induced by heat and by calcium shortage
YML001W	1	267174	267800	ON	13	YPT7	(267174..267800)	GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YMR001C	0	269019	271136	ON	13	CDC5	complement(269019..271136)	Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
YMR001C-A	0	271347	271577	OFF	13	YMR001C-A	complement(271347..271577)	Putative protein of unknown function
YMR002W	1	272193	272663	ON	13	MIC17	(272193..272663)	Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YMR003W	1	273118	273714	ON	13	YMR003W	(273118..273714)	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria; YMR003W is not an essential gene
YMR004W	1	274017	275552	ON	13	MVP1	(274017..275552)	Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
YMR005W	1	276045	277211	ON	13	TAF4	(276045..277211)	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
YMR006C	0	277561	279681	ON	13	PLB2	complement(277561..279681)	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YMR007W	1	279960	280340	OFF	13	YMR007W	(279960..280340)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR008C	0	280590	282584	ON	13	PLB1	complement(280590..282584)	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YMR009W	1	284101	284640	ON	13	ADI1	(284101..284640)	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YMR010W	1	285099	286316	ON	13	YMR010W	(285099..286316)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YMR011W	1	288078	289703	ON	13	HXT2	(288078..289703)	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YMR012W	1	291133	294966	ON	13	CLU1	(291133..294966)	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YMR013C	0	295178	296737	ON	13	SEC59	complement(295178..296737)	Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YMR013C-A	0	296470	296619	OFF	13	YMR013C-A	complement(296470..296619)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C
YMR013W-A	1	298310	298390	OFF	13	YMR013W-A	(298310..298390)	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
YMR014W	1	298867	300426	ON	13	BUD22	(298867..300426)	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YMR015C	0	300868	302484	ON	13	ERG5	complement(300868..302484)	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YMR016C	0	303235	305592	ON	13	SOK2	complement(303235..305592)	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YMR017W	1	307488	308681	ON	13	SPO20	(307488..308681)	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YMR018W	1	310207	311751	ON	13	YMR018W	(310207..311751)	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YMR019W	1	312155	315004	ON	13	STB4	(312155..315004)	Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins
YMR020W	1	315376	316902	ON	13	FMS1	(315376..316902)	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YMR021C	0	317164	318417	ON	13	MAC1	complement(317164..318417)	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YMR022W	1	318679	319176	ON	13	UBC7	(318679..319176)	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
YMR023C	0	319436	321016	ON	13	MSS1	complement(319436..321016)	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
YMR024W	1	321874	323046	ON	13	MRPL3	(321874..323046)	Mitochondrial ribosomal protein of the large subunit
YMR025W	1	323299	324186	ON	13	CSI1	(323299..324186)	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YMR026C	0	324235	325434	ON	13	PEX12	complement(324235..325434)	C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders
YMR027W	1	325876	327288	ON	13	YMR027W	(325876..327288)	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
YMR028W	1	327481	328581	ON	13	TAP42	(327481..328581)	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic s