Gene NameYOL013C (HRD1) (DER3)
SGD DescriptionUbiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
Biological Process• Protein catabolism • Ubiquitin-dependent protein catabolism
Molecular Function• Enzyme activity • Hydrolase activity • Peptidase activity • Ligase activity • Acid-D-amino acid ligase activity • Ubiquitin-protein ligase activity
Cellular Component• Cytoplasm • Endoplasmic reticulum • Endoplasmic reticulum membrane • Endoplasmic reticulum membrane, intrinsic protein • Membrane • Integral to membrane