Gene NameYDR110W (FOB1)
SGD DescriptionNucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
Biological Process• cellular process • cellular physiological process • cell organization and biogenesis • organelle organization and biogenesis • chromosome organization and biogenesis • chromosome organization and biogenesis (sensu Eukaryota) • establishment and/or maintenance of chromatin architecture • chromatin assembly or disassembly • chromatin assembly • heterochromatin formation • chromatin silencing • chromatin silencing at rDNA • chromatin modification • chromatin remodeling • cellular metabolism • nucleobase, nucleoside, nucleotide and nucleic acid metabolism • DNA metabolism • DNA packaging • gene silencing • regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism • negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism • negative regulation of transcription • negative regulation of transcription, DNA-dependent • regulation of transcription • regulation of transcription, DNA-dependent • transcription • transcription, DNA-dependent • regulation of cellular metabolism • negative regulation of cellular metabolism • regulation of cellular physiological process • negative regulation of cellular physiological process • regulation of cellular process • negative regulation of cellular process • development • regulation of gene expression, epigenetic • negative regulation of gene expression, epigenetic • physiological process • metabolism • macromolecule metabolism • biopolymer metabolism • primary metabolism • regulation of metabolism • negative regulation of metabolism • regulation of physiological process • negative regulation of physiological process • regulation of biological process • negative regulation of biological process • cell death • cell aging • replicative cell aging • aging • death • DNA recombination • progressive alteration of chromatin during cell aging • extrachromosomal circular DNA accumulation during cell aging • DNA replication • DNA-dependent DNA replication • regulation of DNA replication • negative regulation of DNA replication • regulation of DNA metabolism • negative regulation of DNA metabolism
Molecular Function• binding • nucleic acid binding • DNA binding • sequence-specific DNA binding • rDNA binding
Cellular Component• cell • intracellular • intracellular organelle • intracellular membrane-bound organelle • nucleus • nuclear lumen • nucleolus • intracellular non-membrane-bound organelle • membrane-enclosed lumen • organelle lumen • organelle • membrane-bound organelle • non-membrane-bound organelle