Gene NameYDL008W (APC11)
SGD DescriptionCatalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
Biological Process• cellular process • cellular physiological process • cell cycle • mitotic cell cycle • mitotic spindle organization and biogenesis • mitotic spindle elongation • cell organization and biogenesis • organelle organization and biogenesis • cytoskeleton organization and biogenesis • microtubule-based process • microtubule cytoskeleton organization and biogenesis • spindle organization and biogenesis • spindle elongation • physiological process • M phase • M phase of mitotic cell cycle • mitosis • mitotic sister chromatid segregation • chromosome segregation • sister chromatid segregation • mitotic metaphase/anaphase transition • regulation of cell cycle • regulation of progression through cell cycle • cyclin catabolism • cellular metabolism • cellular catabolism • cellular macromolecule catabolism • cellular protein catabolism • proteolysis during cellular protein catabolism • modification-dependent protein catabolism • ubiquitin-dependent protein catabolism • proteasomal ubiquitin-dependent protein catabolism • cellular macromolecule metabolism • cellular protein metabolism • proteolysis • regulation of cellular physiological process • regulation of cellular process • metabolism • catabolism • macromolecule catabolism • biopolymer catabolism • protein catabolism • macromolecule metabolism • biopolymer metabolism • protein metabolism • primary metabolism • regulation of physiological process • regulation of biological process • protein modification • ubiquitin cycle • protein ubiquitination • biopolymer modification • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism
Molecular Function• catalytic activity • ligase activity • ligase activity, forming carbon-nitrogen bonds • acid-amino acid ligase activity • ubiquitin-protein ligase activity • binding • protein binding
Cellular Component• cell • intracellular • intracellular organelle • intracellular membrane-bound organelle • nucleus • nuclear ubiquitin ligase complex • anaphase-promoting complex • ubiquitin ligase complex • organelle • membrane-bound organelle • protein complex